@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDK16_HUMAN: (2020-09-06 )
MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMPDSGRPAFRVVDTEF
Atome Classification :
(510 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160-........170.......180..-.....190.......-200-.-.......210.......---220.......230-----.-----.------.-.....240.......250.---.--.-..---..260.......270.......280.......290...-.-...300.......310....----..---.320.......330.......340.......350.....-..360.......370.......380......--.390......--.------400...-...-.410-...-.....420.......430.......440.......450.......460.......470.......480.......490....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
D
R
M
K
K
I
K
R
Q
L
S
M
TLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGE
L
R
SARGPLSS
A
P
E
I
V
H
E
D
L
KMGSDGESDQASATS
S
D
EVQS
P
V
R
V
RMRNHPPRKI
S
T
E
D
I
N
K
R
LSLPADIRLP
E
G
Y
L
E
K
LTLNSPIF
D
K
P
L
S
R
R
L
R
R
V
S
L
S
EIG
F
G
K
--
L
E
T
Y
I
K
L
DKLGEG
T
Y
A
T
V
YKGKS-KL
T
D
N
L
V
A
L
K
E
I
R
L
E-H-E-E-GAP
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---HA
N
I
V
T
L
H
D
I
IH------T-----E------
K
-
S
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
--
G
-
N
I
---
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
RDLKPQ
N
L
L
IN-E-RG
E
L
K
L
A
DFGL
A
R
AKSIPTK----TY---SN
E
V
V
T
L
W
YR
P
P
D
I
L
LGSTDYS
T
Q
I
D
M
W
G
V
G
C
I
F
Y
EMAT-GRPLFPG
S
T
V
E
E
Q
L
H
F
I
F
R
I
LGTPTEETWPG--ILSNEEFKTY--N------Y
P
K
Y
R
A
-
E
A
L
-
L
SH--APR-LDSD
G
A
D
L
L
T
K
L
L
Q
FEGRNRI
S
A
E
D
AMKH
P
F
F
L
S
L
G
E
R
I
HKLPDTT
S
I
F
A
L
K
E
I
Q
L
Q
K
E
ASLRSSSMPDSGR
P
A
F
R
VVDTEF
2
PsiBlast_PDB
93.01
99%
-108
- C1 -
-
5G6V
4
CDK16_HUMAN
A:
[1-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
-
K
L
T
D
N
L
V
A
L
K
E
I
R
L
E
-
H
-
E
-
E
-
G
A
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
I
H
------
T
-----
E
------
K
-
S
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
--
G
-
N
I
---
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
A
-----
K
----
T
Y
---
D
N
E
V
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
-
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
--
I
L
S
N
E
E
F
K
T
Y
--
N
------
Y
P
K
Y
R
A
-
E
A
L
-
L
S
H
--
A
P
R
-
L
D
S
D
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
R
I
H
K
L
P
D
T
T
S
I
F
A
L
K
E
I
Q
L
Q
K
E
A
----------------------
551
HHSearch
92.88
99%
-108
- C1 -
-
5G6V
4
CDK16_HUMAN
A:
[2-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
-
K
L
T
D
N
L
V
A
L
K
E
I
R
L
E
-
H
-
E
-
E
-
G
A
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
I
H
------
T
-----
E
------
K
-
S
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
--
G
-
N
I
---
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
A
-----
K
----
T
Y
---
D
N
E
V
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
-
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
--
I
L
S
N
E
E
F
K
T
Y
--
N
------
Y
P
K
Y
R
A
-
E
A
L
-
L
S
H
--
A
P
R
-
L
D
S
D
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
R
I
H
K
L
P
D
T
T
S
I
F
A
L
K
E
I
Q
L
Q
K
E
A
----------------------
21
Blastp_CBE
92.05
99%
-119
- C1 -
-
5G6V
3
CDK16_HUMAN
B:
[1-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
-
K
L
T
D
N
L
V
A
L
K
E
I
R
L
E
-
H
-
E
-
E
-
G
A
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
I
H
------
T
-----
E
------
K
-
S
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
--
G
-
N
I
---
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
A
-------------------
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
-
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
--
I
L
S
N
E
E
F
K
T
Y
--
N
------
Y
P
K
Y
R
A
-
E
A
L
-
L
S
H
--
A
P
R
-
L
D
S
D
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
R
I
H
K
L
P
D
T
T
S
I
F
A
L
K
E
I
Q
L
Q
K
E
A
S
---------------------
1
PsiBlast_PDB
91.28
99%
-115
- C1 -
-
3MTL
-
CDK16_HUMAN
A:
[1-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
-
K
L
T
D
N
L
V
A
L
K
E
I
R
L
----------
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
I
H
------
T
-----
E
------
K
-
S
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
--
G
-
N
I
---
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
A
K
-------------------
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
-
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
--
I
L
S
N
E
E
F
K
T
Y
--
N
------
Y
P
K
Y
R
A
-
E
A
L
-
L
S
H
--
A
P
R
-
L
D
S
D
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
R
I
H
K
L
P
D
T
T
S
I
F
A
L
K
E
I
Q
L
Q
K
E
-----------------------
550
HHSearch
90.85
99%
-114
- C1 -
-
3MTL
-
CDK16_HUMAN
A:
[2-312]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
-
K
L
T
D
N
L
V
A
L
K
E
I
R
L
----------
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
I
H
------
T
-----
E
------
K
-
S
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
--
G
-
N
I
---
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
A
K
-------------------
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
-
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
--
I
L
S
N
E
E
F
K
T
Y
--
N
------
Y
P
K
Y
R
A
-
E
A
L
-
L
S
H
--
A
P
R
-
L
D
S
D
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
R
I
H
K
L
P
D
T
T
S
I
F
A
L
K
E
I
Q
L
Q
K
E
-----------------------
337
Blastp_CBE
77.70
54%
-121
- C1 -
-
3NIZ
1
?
A:
[18-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
--
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
-
S
-
Q
G
R
I
V
A
L
K
R
I
R
---------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
---
H
P
N
I
V
S
L
I
D
V
I
H
------
S
-----
E
------
R
-
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
E
---
N
--
K
-
T
G
---
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
S
-
D
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----------
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
-
G
K
P
L
F
P
G
V
T
D
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
--
V
Q
E
L
P
L
W
K
Q
R
--
T
------
F
Q
V
F
E
K
-
K
P
W
-
S
S
I
--
I
P
G
-
F
C
Q
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
D
P
Q
I
-------------------------------------------
508
Blastp_CBE
77.13
55%
-120
- C1 -
-
1V0O
1
CDC2H_PLAFK
A:
[3-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
Y
G
E
T
F
-
A
L
K
K
I
R
L
-----------
S
T
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
-----
K
------
K
-
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
--
E
-
G
G
---
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
K
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
--
V
T
E
L
P
K
Y
D
P
---
N
------
F
T
V
Y
E
P
-
L
P
W
-
E
S
F
--
L
K
G
-
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
--------------------------------------------------
507
Blastp_CBE
75.65
55%
-113
- C1 -
-
1V0O
1
CDC2H_PLAFK
B:
[3-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
Y
G
E
T
F
-
A
L
K
K
I
R
L
-------------
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
-----
K
------
K
-
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
--
E
-
G
G
---
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
K
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
--
V
T
E
L
P
K
Y
D
P
---
N
------
F
T
V
Y
E
P
-
L
P
W
-
E
S
F
--
L
K
G
-
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
--------------------------------------------------
563
HHSearch
75.06
54%
-111
- C1 -
-
1V0O
1
CDC2H_PLAFK
B:
[3-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
-
Y
G
E
T
F
A
L
K
K
I
R
L
-------------
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
-----
K
------
K
-
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
--
E
-
G
G
---
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
K
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
--
V
T
E
L
P
K
Y
D
P
---
N
------
F
T
V
Y
E
P
-
L
P
W
-
E
S
F
--
L
K
G
-
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
------------------------------------------------
155
Blastp_CBE
74.79
55%
-57
- C1 -
-
2C5Y
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
----------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
509
Blastp_CBE
74.36
54%
-133
* C1 *
-
1V0P
1
CDC2H_PLAFK
B:
[2-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
Y
G
E
T
F
-
A
L
K
--------------
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
---------------
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
--
E
-
G
G
---
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
--------------------
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
--
V
T
E
L
P
K
Y
D
P
---
N
------
F
T
V
Y
E
P
-
L
P
W
-
E
S
F
--
L
K
G
-
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
--------------------------------------------------
61
Blastp_CBE
73.17
55%
-55
- C1 -
-
4FKU
3
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
13
PsiBlast_PDB
73.09
55%
-48
- C1 -
-
5OSJ
1
CDK2_HUMAN
A:
[7-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-----
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
222
Blastp_CBE
72.79
55%
-57
- C1 -
-
1B38
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
424
Blastp_CBE
72.41
55%
-52
- C1 -
-
2R3P
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
126
Blastp_CBE
72.33
55%
-52
- C1 -
-
2VTL
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
443
Blastp_CBE
72.29
55%
-54
- C1 -
-
4ERW
17
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
S
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
216
Blastp_CBE
72.16
55%
-50
- C1 -
-
1E1X
2
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
96
Blastp_CBE
72.10
55%
-54
- C1 -
-
3IGG
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
432
Blastp_CBE
72.09
55%
-51
- C1 -
-
1W8C
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
W
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
368
Blastp_CBE
72.06
55%
-47
- C1 -
-
2IW9
1
CDK2_HUMAN
A:
[4-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
137
Blastp_CBE
72.01
55%
-55
- C1 -
-
2R3R
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
221
Blastp_CBE
72.00
55%
-55
- C1 -
-
1B39
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
132
Blastp_CBE
71.94
55%
-58
- C1 -
-
2UZO
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
91
Blastp_CBE
71.89
55%
-49
- C1 -
-
3NS9
1
CDK2_HUMAN
A:
[3-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
----------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
68
Blastp_CBE
71.86
55%
-55
- C1 -
-
4FKL
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
188
Blastp_CBE
71.83
55%
-57
- C1 -
-
1PXL
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
425
Blastp_CBE
71.79
55%
-52
- C1 -
-
2R3O
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
246
Blastp_CBE
71.74
55%
-51
- C1 -
-
6Q4C
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
486
Blastp_CBE
71.60
55%
-54
- C1 -
-
5MHQ
1
?
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
-
I
R
L
------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
150
Blastp_CBE
71.70
55%
-51
- C1 -
-
2C6L
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
189
Blastp_CBE
71.68
55%
-58
- C1 -
-
1PXK
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
107
Blastp_CBE
71.68
55%
-50
- C1 -
-
2XMY
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
106
Blastp_CBE
71.64
55%
-47
- C1 -
-
2XNB
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
---
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
75
Blastp_CBE
71.60
55%
-52
- C1 -
-
4EK4
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
172
Blastp_CBE
71.56
55%
-56
- C1 -
-
2A4L
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
153
Blastp_CBE
71.52
55%
-52
- C1 -
-
2C69
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
442
Blastp_CBE
71.34
55%
-50
- C1 -
-
6Q3C
1
CDK2_HUMAN
A:
[10-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
243
Blastp_CBE
71.34
55%
-53
- C1 -
-
6Q4H
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
340
Blastp_CBE
71.31
55%
-54
- C1 -
-
5OO3
1
CDK2_HUMAN
A:
[7-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
131
Blastp_CBE
71.29
55%
-50
- C1 -
-
2V0D
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
140
Blastp_CBE
71.20
55%
-51
- C1 -
-
2R3F
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
217
Blastp_CBE
71.19
55%
-47
- C1 -
-
1E1V
2
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
147
Blastp_CBE
71.18
55%
-51
- C1 -
-
2CLX
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
74
Blastp_CBE
71.18
55%
-51
- C1 -
-
4EK5
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
152
Blastp_CBE
71.14
55%
-55
- C1 -
-
2C6I
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
151
Blastp_CBE
71.11
55%
-51
- C1 -
-
2C6K
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
248
Blastp_CBE
71.04
55%
-49
- C1 -
-
6Q4A
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
-
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
201
Blastp_CBE
71.05
55%
-51
- C1 -
-
1JSV
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
148
Blastp_CBE
71.04
55%
-51
- C1 -
-
2C6O
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
205
Blastp_CBE
70.98
55%
-52
- C1 -
-
1H08
2
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
67
Blastp_CBE
70.97
55%
-55
- C1 -
-
4FKO
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
449
Blastp_CBE
70.96
55%
-51
- C1 -
-
4RJ3
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
L
I
R
L
D
-
T
---------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
187
Blastp_CBE
70.93
55%
-50
- C1 -
-
1PXM
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
70
Blastp_CBE
70.93
55%
-48
- C1 -
-
4FKI
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
506
Blastp_CBE
70.90
55%
-40
- C1 -
-
4EOI
2
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
D
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
431
Blastp_CBE
70.86
55%
-55
- C1 -
-
2R3I
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
366
Blastp_CBE
70.81
55%
-41
- C1 -
-
4EOS
1
CDK2_HUMAN
A:
[2-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-----
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
119
Blastp_CBE
70.76
55%
-55
- C1 -
-
2VTS
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
343
Blastp_CBE
70.74
55%
-47
- C1 -
-
6Q4I
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
L
---
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
133
Blastp_CBE
70.71
55%
-58
- C1 -
-
2UZN
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
176
Blastp_CBE
70.67
55%
-56
- C1 -
-
1Y8Y
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
241
Blastp_CBE
70.66
55%
-51
- C1 -
-
6Q4K
3
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
41
Blastp_CBE
70.60
55%
-51
- C1 -
-
5JQ5
1
CDK2_HUMAN
A:
[3-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
149
Blastp_CBE
70.56
55%
-51
- C1 -
-
2C6M
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
125
Blastp_CBE
70.55
55%
-50
- C1 -
-
2VTM
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
465
Blastp_CBE
70.52
55%
-41
- C1 -
-
6GVA
3
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
---
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
339
Blastp_CBE
70.44
55%
-48
- C1 -
-
5OSM
1
CDK2_HUMAN
A:
[3-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
154
Blastp_CBE
70.45
55%
-50
- C1 -
-
2C68
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
59
Blastp_CBE
70.44
55%
-62
- C1 -
-
4FKW
2
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
139
Blastp_CBE
70.41
55%
-50
- C1 -
-
2R3G
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
138
Blastp_CBE
70.37
55%
-51
- C1 -
-
2R3H
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
219
Blastp_CBE
70.32
55%
-51
- C1 -
-
1DI8
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
95
Blastp_CBE
70.31
55%
-46
- C1 -
-
3LE6
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
--------------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
92
Blastp_CBE
70.20
55%
-45
- C1 -
-
3LFS
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
448
Blastp_CBE
70.08
55%
-44
- C1 -
-
4EOO
1
CDK2_HUMAN
A:
[1-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
242
Blastp_CBE
70.15
55%
-55
- C1 -
-
6Q4J
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
195
Blastp_CBE
70.14
55%
-59
- C1 -
-
1KE9
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
435
Blastp_CBE
70.09
55%
-38
- C1 -
-
4EOJ
1
CDK2_HUMAN
A:
[3-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
120
Blastp_CBE
70.08
55%
-49
- C1 -
-
2VTR
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
423
Blastp_CBE
69.96
55%
-50
- C1 -
-
2R3Q
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
220
Blastp_CBE
69.97
55%
-60
- C1 -
-
1CKP
2
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
93
Blastp_CBE
69.96
55%
-47
- C1 -
-
3LFQ
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
204
Blastp_CBE
69.92
55%
-48
- C1 -
-
1H0V
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
198
Blastp_CBE
69.90
55%
-62
- C1 -
-
1KE6
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
440
Blastp_CBE
69.78
55%
-49
- C1 -
-
6Q4F
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
98
Blastp_CBE
69.85
55%
-52
- C1 -
-
3FZ1
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
358
Blastp_CBE
69.79
55%
-55
- C1 -
-
1GII
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
H
V
H
Q
D
L
K
T
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
247
Blastp_CBE
69.84
55%
-49
- C1 -
-
6Q4B
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
123
Blastp_CBE
69.82
55%
-54
- C1 -
-
2VTO
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
81
Blastp_CBE
69.79
55%
-58
- C1 -
-
3WBL
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
T
G
E
V
V
A
L
K
K
I
R
L
--------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
197
Blastp_CBE
69.78
55%
-57
- C1 -
-
1KE7
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
175
Blastp_CBE
69.73
55%
-56
- C1 -
-
1Y91
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
43
Blastp_CBE
69.68
55%
-56
- C1 -
-
5IEX
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
462
Blastp_CBE
69.65
55%
-43
- C1 -
-
4EOR
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
206
Blastp_CBE
69.61
55%
-49
- C1 -
-
1H07
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
----
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
264
Blastp_CBE
69.57
55%
-54
- C1 -
-
3RPR
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
42
Blastp_CBE
69.55
55%
-54
- C1 -
-
5IEY
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
44
Blastp_CBE
69.54
55%
-55
- C1 -
-
5IEV
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
65
Blastp_CBE
69.51
55%
-54
- C1 -
-
4FKQ
2
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
136
Blastp_CBE
69.48
55%
-59
- C1 -
-
2R64
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
37
Blastp_CBE
69.48
55%
-52
- C1 -
-
5K4J
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
128
Blastp_CBE
69.42
55%
-59
- C1 -
-
2VTI
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
178
Blastp_CBE
69.40
55%
-59
- C1 -
-
1W0X
1
CDK2_HUMAN
C:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
90
Blastp_CBE
69.37
55%
-58
- C1 -
-
3S2P
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
196
Blastp_CBE
69.28
55%
-55
- C1 -
-
1KE8
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
245
Blastp_CBE
69.29
55%
-51
- C1 -
-
6Q4D
6
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
71
Blastp_CBE
69.28
55%
-49
- C1 -
-
4FKG
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
279
Blastp_CBE
69.27
55%
-53
- C1 -
-
3RAH
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
50
Blastp_CBE
69.25
55%
-54
- C1 -
-
5ANI
1
CDK2_HUMAN
A:
[2-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
199
Blastp_CBE
69.24
55%
-60
- C1 -
-
1KE5
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
318
Blastp_CBE
69.23
55%
-53
- C1 -
-
3QTS
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
66
Blastp_CBE
69.20
55%
-55
- C1 -
-
4FKP
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
114
Blastp_CBE
69.14
55%
-50
- C1 -
-
2W06
2
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
79
Blastp_CBE
69.06
55%
-61
- C1 -
-
4BGH
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
97
Blastp_CBE
69.04
55%
-53
- C1 -
-
3IG7
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
129
Blastp_CBE
69.03
55%
-57
- C1 -
-
2VTH
2
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
22
Blastp_CBE
68.98
58%
-54
- C1 -
-
4AU8
2
CDK5_HUMAN
B:
[6-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
L
------
E
-
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
------------
K
-
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
--
N
-
G
D
---
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
-------------
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
--
M
T
K
L
P
D
Y
K
P
----------
Y
P
M
Y
P
A
T
T
S
L
-
V
N
V
--
V
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------
212
Blastp_CBE
68.97
55%
-54
- C1 -
-
1FVT
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
439
Blastp_CBE
68.95
55%
-43
- C1 -
-
4EOK
1
CDK2_HUMAN
A:
[3-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
319
Blastp_CBE
68.92
55%
-52
- C1 -
-
3QTR
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
60
Blastp_CBE
68.89
55%
-54
- C1 -
-
4FKV
2
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
130
Blastp_CBE
68.87
55%
-57
- C1 -
-
2VTA
3
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
294
Blastp_CBE
68.79
55%
-53
- C1 -
-
3R7I
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
64
Blastp_CBE
68.79
55%
-53
- C1 -
-
4FKR
2
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
281
Blastp_CBE
68.67
55%
-51
- C1 -
-
3R9N
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
342
Blastp_CBE
68.55
55%
-53
- C1 -
-
6Q4G
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
E
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
203
Blastp_CBE
68.51
55%
-55
- C1 -
-
1H0W
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
72
Blastp_CBE
68.46
55%
-52
- C1 -
-
4EK8
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
164
Blastp_CBE
68.45
55%
-60
- C1 -
-
2BTS
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
84
Blastp_CBE
68.43
55%
-53
- C1 -
-
3ULI
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
293
Blastp_CBE
68.39
55%
-53
- C1 -
-
3R7U
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
3
PsiBlast_PDB
68.42
58%
-47
- C1 -
-
4AU8
2
CDK5_HUMAN
A:
[6-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
------------
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
---------------------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
--
N
-
G
D
---
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
---------
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
--
M
T
K
L
P
D
Y
K
P
----------
Y
P
M
Y
P
A
T
T
S
L
-
V
N
V
--
V
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------
122
Blastp_CBE
68.41
55%
-49
- C1 -
-
2VTP
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
251
Blastp_CBE
68.40
55%
-54
- C1 -
-
6Q3B
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
54
Blastp_CBE
68.39
55%
-50
- C1 -
-
5A14
2
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
---
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
63
Blastp_CBE
68.38
55%
-59
- C1 -
-
4FKS
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
40
Blastp_CBE
68.38
55%
-54
- C1 -
-
5JQ8
1
CDK2_HUMAN
A:
[3-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
62
Blastp_CBE
68.30
55%
-52
- C1 -
-
4FKT
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
262
Blastp_CBE
68.23
55%
-56
- C1 -
-
3RPY
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
69
Blastp_CBE
68.17
55%
-55
- C1 -
-
4FKJ
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
207
Blastp_CBE
68.16
55%
-52
- C1 -
-
1H00
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
141
Blastp_CBE
68.15
55%
-57
- C1 -
-
2J9M
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
34
Blastp_CBE
68.09
51%
-14
- C1 -
-
4YC3
1
CDK1_HUMAN
A:
[5-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
-
E
-
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
-----
D
------
S
-
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
PP
G
-
Q
Y
---
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
---
T
---
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
--
V
E
S
L
Q
D
Y
K
N
---
T
------
F
P
K
W
K
P
-
G
S
L
-
A
S
H
--
V
K
N
-
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
L
D
N
Q
I
K
K
M
----------------------------------------
15
PsiBlast_PDB
68.05
55%
-5
- C1 -
-
1OI9
1
CDK2_HUMAN
A:
[4-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
280
Blastp_CBE
68.01
55%
-50
- C1 -
-
3R9O
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
78
Blastp_CBE
68.02
55%
-56
- C1 -
-
4BZD
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
179
Blastp_CBE
68.01
55%
-48
- C1 -
-
1VYZ
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
430
Blastp_CBE
68.00
55%
-56
- C1 -
-
2R3J
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
88
Blastp_CBE
67.97
55%
-57
- C1 -
-
3SW7
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
115
Blastp_CBE
67.83
55%
-58
- C1 -
-
2W05
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
--------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
116
Blastp_CBE
67.80
55%
-57
- C1 -
-
2VV9
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
427
Blastp_CBE
67.67
55%
-55
- C1 -
-
2R3M
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
429
Blastp_CBE
67.75
55%
-57
- C1 -
-
2R3K
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
351
Blastp_CBE
67.74
55%
-7
- C1 -
-
4CFN
1
CDK2_HUMAN
C:
[2-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
117
Blastp_CBE
67.72
55%
-49
- C1 -
-
2VU3
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
----
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
11
PsiBlast_PDB
67.72
55%
-53
- C1 -
-
3EZV
1
CDK2_HUMAN
A:
[3-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
53
Blastp_CBE
67.69
55%
-60
- C1 -
-
5AND
1
CDK2_HUMAN
A:
[2-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
77
Blastp_CBE
67.67
55%
-53
- C1 -
-
4D1X
1
CDK2_HUMAN
A:
[3-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
25
Blastp_CBE
67.67
58%
-60
- C1 -
-
1UNG
1
CDK5_HUMAN
B:
[2-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
Y
E
K
L
E
K
-------
T
V
F
K
A
--------
I
V
A
L
K
R
V
R
L
D
-------
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
-----
D
------
K
-
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
--
N
-
G
D
---
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
---
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
--
M
T
K
L
P
D
Y
K
P
----------
Y
P
M
Y
P
A
T
T
S
L
-
V
N
V
--
V
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------
6
PsiBlast_PDB
67.66
57%
-11
- C1 -
-
1UNL
1
CDK5_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
-
D
-
D
D
E
-
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
-----
D
------
K
-
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
--
N
-
G
D
---
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
---
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
--
M
T
K
L
P
D
Y
K
P
----------
Y
P
M
Y
P
A
T
T
S
L
-
V
N
V
--
V
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------
27
Blastp_CBE
67.64
51%
-13
- C1 -
-
6GU6
1
CDK1_HUMAN
A:
[6-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
-
E
-
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
-----
D
------
S
-
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
PP
G
-
Q
Y
---
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
----------
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
--
V
E
S
L
Q
D
Y
K
N
---
T
------
F
P
K
W
K
P
-
G
S
L
-
A
S
H
--
V
K
N
-
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
L
D
----------------------------------------------
180
Blastp_CBE
67.62
55%
-60
- C1 -
-
1V1K
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
56
Blastp_CBE
67.59
55%
-4
- C1 -
-
4KD1
2
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
166
Blastp_CBE
67.54
55%
-59
- C1 -
-
2BHH
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
218
Blastp_CBE
67.53
55%
-59
- C1 -
-
1DM2
5
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
244
Blastp_CBE
67.52
55%
-54
- C1 -
-
6Q4E
3
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
261
Blastp_CBE
67.48
55%
-49
- C1 -
-
3RZB
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
394
Blastp_CBE
67.40
55%
-6
- C1 -
-
5NEV
1
?
C:
[5-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
181
Blastp_CBE
67.46
55%
-63
- C1 -
-
1URW
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
14
PsiBlast_PDB
67.44
55%
-4
- C1 -
-
1OGU
1
CDK2_HUMAN
A:
[2-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
459
Blastp_CBE
67.34
55%
-4
- C1 -
-
4EON
1
CDK2_HUMAN
C:
[1-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
488
Blastp_CBE
67.43
55%
-7
- C1 -
-
4II5
2
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
228
Blastp_CBE
67.42
55%
-8
- C1 -
-
2WPA
1
CDK2_HUMAN
A:
[6-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
223
Blastp_CBE
67.40
55%
-48
- C1 -
-
1AQ1
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
--------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
395
Blastp_CBE
67.39
55%
-5
- C1 -
-
5NEV
1
CDK2_HUMAN
A:
[5-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
73
Blastp_CBE
67.38
55%
-51
- C1 -
-
4EK6
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
420
Blastp_CBE
67.28
55%
-5
- C1 -
-
3QHR
2
CDK2_HUMAN
C:
[1-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
33
Blastp_CBE
67.36
51%
-12
- C1 -
-
5HQ0
1
CDK1_HUMAN
A:
[3-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
--
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
-
E
-
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
-----
D
------
S
-
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
PP
G
-
Q
Y
---
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
---
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
--
V
E
S
L
Q
D
Y
K
N
---
T
------
F
P
K
W
K
P
-
G
S
L
-
A
S
H
--
V
K
N
-
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
------------------------------------------------
28
Blastp_CBE
67.34
51%
-12
- C1 -
-
6GU4
1
CDK1_HUMAN
A:
[3-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
--
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
-
E
-
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
-----
D
------
S
-
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
PP
G
-
Q
Y
---
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
---
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
--
V
E
S
L
Q
D
Y
K
N
---
T
------
F
P
K
W
K
P
-
G
S
L
-
A
S
H
--
V
K
N
-
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
------------------------------------------------
505
Blastp_CBE
67.33
55%
-6
- C1 -
-
4EOI
1
CDK2_HUMAN
C:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
D
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
412
Blastp_CBE
67.24
55%
-9
- C1 -
-
1H1P
1
CDK2_HUMAN
A:
[5-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
174
Blastp_CBE
67.30
55%
-2
- C1 -
-
1YKR
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
370
Blastp_CBE
67.28
55%
-9
- C1 -
-
2IW6
1
CDK2_HUMAN
A:
[4-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
328
Blastp_CBE
67.24
55%
-3
- C1 -
-
3QQF
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
380
Blastp_CBE
67.17
55%
-4
- C1 -
-
4BCN
1
CDK2_HUMAN
C:
[1-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
357
Blastp_CBE
67.20
55%
-49
- C1 -
-
1GIJ
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
H
V
H
Q
D
L
K
T
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
240
Blastp_CBE
67.17
55%
-10
- C1 -
-
1VYW
1
CDK2_HUMAN
A:
[6-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
466
Blastp_CBE
67.16
55%
-6
- C1 -
-
5LMK
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
237
Blastp_CBE
67.15
55%
-12
- C1 -
-
2BKZ
1
CDK2_HUMAN
C:
[6-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
406
Blastp_CBE
67.06
55%
-8
- C1 -
-
1H1S
1
CDK2_HUMAN
A:
[5-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
226
Blastp_CBE
67.12
55%
-8
- C1 -
-
2WXV
1
CDK2_HUMAN
A:
[6-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
344
Blastp_CBE
67.07
55%
-59
- C1 -
-
1OIT
1
CDK2_HUMAN
A:
[3-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
-
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
S
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
89
Blastp_CBE
67.12
55%
-55
- C1 -
-
3SW4
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
274
Blastp_CBE
67.06
55%
-0
- C1 -
-
3RK5
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
30
Blastp_CBE
67.07
51%
-14
- C1 -
-
6GU2
1
CDK1_HUMAN
A:
[3-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
--
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
-
E
-
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
-----
D
------
S
-
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
PP
G
-
Q
Y
---
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
---
T
---
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
--
V
E
S
L
Q
D
Y
K
N
---
T
------
F
P
K
W
K
P
-
G
S
L
-
A
S
H
--
V
K
N
-
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
L
D
N
Q
I
-------------------------------------------
113
Blastp_CBE
67.06
55%
-60
- C1 -
-
2W17
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
-
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
--------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
100
Blastp_CBE
67.06
55%
-12
- C1 -
-
3F5X
2
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
-
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
165
Blastp_CBE
67.05
55%
-52
- C1 -
-
2BTR
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
144
Blastp_CBE
67.02
55%
-49
- C1 -
-
2FVD
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------------
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
--
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
277
Blastp_CBE
66.98
55%
-56
- C1 -
-
3RAK
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
478
Blastp_CBE
66.87
55%
-9
- C1 -
-
2CCH
1
CDK2_HUMAN
C:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
168
Blastp_CBE
66.97
55%
-51
- C1 -
-
2B55
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
----------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
418
Blastp_CBE
66.96
55%
-2
- C1 -
-
3QHW
3
CDK2_HUMAN
C:
[1-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
258
Blastp_CBE
66.94
55%
-56
- C1 -
-
3S1H
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
381
Blastp_CBE
66.87
55%
-6
- C1 -
-
4BCN
1
CDK2_HUMAN
A:
[2-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
453
Blastp_CBE
66.93
55%
-5
- C1 -
-
4EOM
1
CDK2_HUMAN
A:
[3-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
127
Blastp_CBE
66.92
55%
-53
- C1 -
-
2VTJ
2
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
80
Blastp_CBE
66.90
55%
-51
- C1 -
-
4ACM
3
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
--------------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
321
Blastp_CBE
66.87
55%
-5
- C1 -
-
3QRU
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
238
Blastp_CBE
66.86
55%
-12
- C1 -
-
2BKZ
1
CDK2_HUMAN
A:
[6-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
302
Blastp_CBE
66.82
55%
2
- C1 -
-
3R1Q
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
446
Blastp_CBE
66.76
55%
-5
- C1 -
-
4EOP
1
CDK2_HUMAN
A:
[2-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
23
Blastp_CBE
66.85
58%
-64
- C1 -
-
3O0G
1
CDK5_HUMAN
B:
[6-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
K
I
-----
G
T
V
F
K
A
-------
E
I
V
A
L
K
R
V
R
-----------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
-----
D
------
K
-
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
--
N
-
G
D
---
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
---
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
--
M
T
K
L
P
D
Y
K
P
----------
Y
P
M
Y
P
A
T
T
S
L
-
V
N
V
--
V
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------
299
Blastp_CBE
66.84
55%
1
- C1 -
-
3R28
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
209
Blastp_CBE
66.83
55%
-56
- C1 -
-
1G5S
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
369
Blastp_CBE
66.76
55%
-7
- C1 -
-
2IW6
1
CDK2_HUMAN
C:
[4-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
269
Blastp_CBE
66.81
55%
-3
- C1 -
-
3RM7
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
322
Blastp_CBE
66.76
55%
-4
- C1 -
-
3QRT
3
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
324
Blastp_CBE
66.74
55%
-4
- C1 -
-
3QQK
6
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
438
Blastp_CBE
66.65
55%
-1
- C1 -
-
4EOK
1
CDK2_HUMAN
C:
[1-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
496
Blastp_CBE
66.62
55%
-6
- C1 -
-
2UZB
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
265
Blastp_CBE
66.73
55%
-4
- C1 -
-
3RPO
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
422
Blastp_CBE
66.62
55%
-50
- C1 -
-
4NJ3
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
487
Blastp_CBE
66.67
55%
-7
- C1 -
-
4II5
3
CDK2_HUMAN
C:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
421
Blastp_CBE
66.66
55%
-5
- C1 -
-
3QHR
6
CDK2_HUMAN
A:
[1-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
18
PsiBlast_PDB
66.65
55%
-5
- C1 -
-
4CFN
1
CDK2_HUMAN
A:
[2-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
276
Blastp_CBE
66.63
55%
-55
- C1 -
-
3RAL
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
297
Blastp_CBE
66.62
55%
-1
- C1 -
-
3R71
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
389
Blastp_CBE
66.55
55%
-2
- C1 -
-
3BHV
2
CDK2_HUMAN
A:
[1-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
464
Blastp_CBE
66.61
55%
-2
- C1 -
-
4I3Z
4
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
484
Blastp_CBE
66.50
55%
-7
- C1 -
-
1GY3
2
CDK2_HUMAN
C:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
419
Blastp_CBE
66.60
55%
-2
- C1 -
-
3QHW
2
CDK2_HUMAN
A:
[1-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
323
Blastp_CBE
66.59
55%
-1
- C1 -
-
3QQL
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
268
Blastp_CBE
66.55
55%
-53
- C1 -
-
3RMF
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
266
Blastp_CBE
66.55
55%
-1
- C1 -
-
3ROY
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
372
Blastp_CBE
66.57
55%
-2
- C1 -
-
4CFV
1
CDK2_HUMAN
A:
[4-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
311
Blastp_CBE
66.56
55%
-4
- C1 -
-
3QWK
5
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
398
Blastp_CBE
66.48
55%
-5
- C1 -
-
4CFX
1
CDK2_HUMAN
C:
[5-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
145
Blastp_CBE
66.55
55%
1
- C1 -
-
2EXM
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
308
Blastp_CBE
66.50
55%
-2
- C1 -
-
3QXO
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
374
Blastp_CBE
66.48
55%
-1
- C1 -
-
4CFU
1
CDK2_HUMAN
A:
[4-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
469
Blastp_CBE
66.54
55%
-6
- C1 -
-
3DOG
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
510
Blastp_CBE
66.42
54%
-19
- C1 -
-
1V0P
1
CDC2H_PLAFK
A:
[1-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
Y
G
E
T
F
-
A
L
K
K
I
R
L
E
-
K
-
E
D
E
-
G
I
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
I
H
------
T
-----
K
------
K
-
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
--
E
-
G
G
---
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
----------------
I
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
--
V
T
E
L
P
K
Y
D
P
---
N
------
F
T
V
Y
E
P
-
L
P
W
-
E
S
F
--
L
K
G
-
L
D
E
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
--------------------------------------------------
161
Blastp_CBE
66.53
55%
-7
- C1 -
-
2C5O
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
252
Blastp_CBE
66.50
55%
-53
- C1 -
-
6GUK
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
463
Blastp_CBE
66.52
55%
-1
- C1 -
-
4I3Z
3
CDK2_HUMAN
C:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
286
Blastp_CBE
66.48
55%
-3
- C1 -
-
3R8U
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
411
Blastp_CBE
66.51
55%
-10
- C1 -
-
1H1P
1
CDK2_HUMAN
C:
[5-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
191
Blastp_CBE
66.50
55%
-4
- C1 -
-
1PXI
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
29
Blastp_CBE
66.48
51%
-11
- C1 -
-
6GU3
1
CDK1_HUMAN
A:
[3-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
--
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
-
E
-
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
M
------
Q
-----
D
------
S
-
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
PP
G
-
Q
Y
---
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
---
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
--
V
E
S
L
Q
D
Y
K
N
---
T
------
F
P
K
W
K
P
-
G
S
L
-
A
S
H
--
V
K
N
-
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
------------------------------------------------
99
Blastp_CBE
66.47
55%
-9
- C1 -
-
3F5X
2
CDK2_HUMAN
C:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
499
Blastp_CBE
66.46
55%
-6
- C1 -
-
2C6T
1
CDK2_HUMAN
C:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
467
Blastp_CBE
66.44
55%
-4
- C1 -
-
5L2W
2
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
300
Blastp_CBE
66.40
55%
-2
- C1 -
-
3R1Y
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
495
Blastp_CBE
66.31
55%
-10
- C1 -
-
2UZB
1
CDK2_HUMAN
C:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
208
Blastp_CBE
66.42
55%
-56
- C1 -
-
1GIH
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
173
Blastp_CBE
66.41
55%
-2
- C1 -
-
2A0C
1
CDK2_HUMAN
X:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
9
PsiBlast_PDB
66.40
55%
-3
- C1 -
-
2IW8
1
CDK2_HUMAN
A:
[4-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
H
V
D
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
393
Blastp_CBE
66.31
55%
-5
- C1 -
-
3BHT
1
CDK2_HUMAN
A:
[1-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
407
Blastp_CBE
66.30
55%
-5
- C1 -
-
1H1R
1
CDK2_HUMAN
C:
[5-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
397
Blastp_CBE
66.37
55%
-4
- C1 -
-
5CYI
1
CDK2_HUMAN
A:
[5-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
304
Blastp_CBE
66.31
55%
4
- C1 -
-
3QZH
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
460
Blastp_CBE
66.25
55%
-2
- C1 -
-
4EON
1
CDK2_HUMAN
A:
[1-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
295
Blastp_CBE
66.31
55%
1
- C1 -
-
3R7E
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
309
Blastp_CBE
66.30
55%
-2
- C1 -
-
3QX4
3
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
298
Blastp_CBE
66.34
55%
-2
- C1 -
-
3R6X
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
475
Blastp_CBE
66.33
55%
-3
- C1 -
-
2G9X
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
272
Blastp_CBE
66.32
55%
-1
- C1 -
-
3RK9
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
283
Blastp_CBE
66.28
55%
1
- C1 -
-
3R9D
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
287
Blastp_CBE
66.30
55%
-1
- C1 -
-
3R8P
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
310
Blastp_CBE
66.25
55%
-2
- C1 -
-
3QX2
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
291
Blastp_CBE
66.29
55%
-4
- C1 -
-
3R7Y
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
213
Blastp_CBE
66.28
55%
-12
- C1 -
-
1FIN
1
CDK2_HUMAN
C:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
447
Blastp_CBE
66.18
55%
-4
- C1 -
-
4EOO
1
CDK2_HUMAN
C:
[1-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
391
Blastp_CBE
66.20
55%
-0
- C1 -
-
3BHU
1
CDK2_HUMAN
A:
[1-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
382
Blastp_CBE
66.20
55%
-6
- C1 -
-
4BCK
1
CDK2_HUMAN
C:
[1-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
48
Blastp_CBE
66.25
55%
-57
- C1 -
-
5ANK
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
----------------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
230
Blastp_CBE
66.23
55%
-11
- C1 -
-
2WIP
1
CDK2_HUMAN
A:
[6-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
202
Blastp_CBE
66.23
55%
1
- C1 -
-
1HCK
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
233
Blastp_CBE
66.21
55%
-7
- C1 -
-
2C4G
1
CDK2_HUMAN
C:
[6-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
436
Blastp_CBE
66.12
55%
-4
- C1 -
-
4EOL
1
CDK2_HUMAN
C:
[1-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
379
Blastp_CBE
66.20
55%
-4
- C1 -
-
4BCO
1
CDK2_HUMAN
A:
[2-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
445
Blastp_CBE
66.19
55%
-1
- C1 -
-
4EOP
1
CDK2_HUMAN
C:
[3-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
49
Blastp_CBE
66.18
55%
-3
- C1 -
-
5ANJ
1
CDK2_HUMAN
A:
[3-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
492
Blastp_CBE
66.06
55%
-9
- C1 -
-
2UZE
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
227
Blastp_CBE
66.17
55%
-5
- C1 -
-
2WPA
1
CDK2_HUMAN
C:
[6-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
347
Blastp_CBE
66.08
55%
-4
- C1 -
-
6GUF
1
CDK2_HUMAN
A:
[4-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
396
Blastp_CBE
66.06
55%
-2
- C1 -
-
5CYI
1
CDK2_HUMAN
C:
[5-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
383
Blastp_CBE
66.13
55%
1
- C1 -
-
4BCK
2
CDK2_HUMAN
A:
[1-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
349
Blastp_CBE
66.12
55%
-5
- C1 -
-
6GUC
1
CDK2_HUMAN
C:
[4-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
282
Blastp_CBE
66.11
55%
-0
- C1 -
-
3R9H
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
493
Blastp_CBE
65.98
55%
-15
- C1 -
-
2UZD
1
CDK2_HUMAN
C:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
10
PsiBlast_PDB
66.09
55%
-50
- C1 -
-
3EZR
2
CDK2_HUMAN
A:
[3-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
-------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
19
PsiBlast_PDB
66.08
55%
-4
- C1 -
-
6GUB
1
CDK2_HUMAN
A:
[4-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
17
PsiBlast_PDB
66.06
55%
-4
- C1 -
-
1OIY
1
CDK2_HUMAN
A:
[4-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
490
Blastp_CBE
66.05
55%
-7
- C1 -
-
2UZL
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
384
Blastp_CBE
65.98
55%
-1
- C1 -
-
3TNW
1
CDK2_HUMAN
C:
[3-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
263
Blastp_CBE
66.04
55%
-3
- C1 -
-
3RPV
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
229
Blastp_CBE
66.03
55%
-10
- C1 -
-
2WIP
1
CDK2_HUMAN
C:
[6-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
118
Blastp_CBE
66.02
55%
-51
- C1 -
-
2VTT
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
489
Blastp_CBE
65.90
55%
-8
- C1 -
-
2UZL
1
CDK2_HUMAN
C:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
146
Blastp_CBE
66.01
55%
-52
- C1 -
-
2DUV
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
----------------
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
234
Blastp_CBE
66.00
55%
-6
- C1 -
-
2C4G
1
CDK2_HUMAN
A:
[6-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
471
Blastp_CBE
65.78
55%
-5
- C1 -
-
3DDQ
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
103
Blastp_CBE
65.98
55%
-5
- C1 -
-
3EJ1
1
CDK2_HUMAN
C:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
232
Blastp_CBE
65.97
55%
-4
- C1 -
-
2WIH
1
CDK2_HUMAN
A:
[6-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
278
Blastp_CBE
65.96
55%
-1
- C1 -
-
3RAI
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
290
Blastp_CBE
65.94
55%
-1
- C1 -
-
3R83
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
285
Blastp_CBE
65.89
55%
-1
- C1 -
-
3R8V
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
296
Blastp_CBE
65.90
55%
-3
- C1 -
-
3R73
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
111
Blastp_CBE
65.89
55%
-7
- C1 -
-
2WEV
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
312
Blastp_CBE
65.88
55%
-3
- C1 -
-
3QWJ
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
271
Blastp_CBE
65.87
55%
-2
- C1 -
-
3RKB
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
163
Blastp_CBE
65.84
55%
-11
- C1 -
-
2C5N
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
57
Blastp_CBE
65.84
55%
-6
- C1 -
-
4FX3
1
CDK2_HUMAN
C:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
254
Blastp_CBE
65.80
55%
2
- C1 -
-
4GCJ
5
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
476
Blastp_CBE
65.71
55%
-11
- C1 -
-
2CCI
1
CDK2_HUMAN
C:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
52
Blastp_CBE
65.81
55%
-2
- C1 -
-
5ANE
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
403
Blastp_CBE
65.73
55%
-2
- C1 -
-
4CFM
1
CDK2_HUMAN
A:
[5-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
184
Blastp_CBE
65.80
55%
3
- C1 -
-
1PXP
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
360
Blastp_CBE
65.79
55%
-8
- C1 -
-
4EOQ
1
CDK2_HUMAN
A:
[3-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
385
Blastp_CBE
65.78
55%
-9
- C1 -
-
3TNW
1
CDK2_HUMAN
A:
[2-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
270
Blastp_CBE
65.75
55%
2
- C1 -
-
3RM6
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
-
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
135
Blastp_CBE
65.76
55%
-9
- C1 -
-
2UUE
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
85
Blastp_CBE
65.75
55%
0
- C1 -
-
3TIZ
9
CDK2_HUMAN
A:
[2-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
363
Blastp_CBE
65.73
55%
-7
- C1 -
-
4BCM
1
CDK2_HUMAN
C:
[3-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
16
PsiBlast_PDB
65.71
55%
-5
- C1 -
-
1OIU
1
CDK2_HUMAN
A:
[2-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
160
Blastp_CBE
65.69
55%
-9
- C1 -
-
2C5O
1
CDK2_HUMAN
C:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
444
Blastp_CBE
65.58
55%
-4
- C1 -
-
6GUE
1
CDK2_HUMAN
A:
[4-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
N
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
377
Blastp_CBE
65.60
55%
-3
- C1 -
-
4BCP
1
CDK2_HUMAN
A:
[2-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
231
Blastp_CBE
65.65
55%
-9
- C1 -
-
2WIH
1
CDK2_HUMAN
C:
[6-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
408
Blastp_CBE
65.64
55%
1
- C1 -
-
1H1R
1
CDK2_HUMAN
A:
[5-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
500
Blastp_CBE
65.52
55%
-4
- C1 -
-
2C6T
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
313
Blastp_CBE
65.63
55%
-1
- C1 -
-
3QU0
5
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
361
Blastp_CBE
65.55
55%
-4
- C1 -
-
4BCQ
1
CDK2_HUMAN
C:
[3-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
477
Blastp_CBE
65.50
55%
-5
- C1 -
-
2CCI
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
273
Blastp_CBE
65.60
55%
-0
- C1 -
-
3RK7
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
235
Blastp_CBE
65.58
55%
-6
- C1 -
-
2BPM
1
CDK2_HUMAN
C:
[6-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
400
Blastp_CBE
65.52
55%
-2
- C1 -
-
4CFW
1
CDK2_HUMAN
C:
[4-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
316
Blastp_CBE
65.54
55%
-1
- C1 -
-
3QTW
6
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
456
Blastp_CBE
65.49
55%
-7
- C1 -
-
1PKD
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
211
Blastp_CBE
65.58
55%
-5
- C1 -
-
1FVV
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
267
Blastp_CBE
65.57
55%
1
- C1 -
-
3RNI
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
124
Blastp_CBE
65.55
55%
-51
- C1 -
-
2VTN
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
479
Blastp_CBE
65.44
55%
-10
- C1 -
-
2CCH
3
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
399
Blastp_CBE
65.47
55%
-9
- C1 -
-
4CFX
1
CDK2_HUMAN
A:
[5-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
305
Blastp_CBE
65.50
55%
-2
- C1 -
-
3QZG
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
20
PsiBlast_PDB
65.54
55%
-3
- C1 -
-
6GUC
1
CDK2_HUMAN
A:
[4-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
292
Blastp_CBE
65.53
55%
-1
- C1 -
-
3R7V
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
170
Blastp_CBE
65.52
55%
2
- C1 -
-
2B53
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
301
Blastp_CBE
65.51
55%
2
- C1 -
-
3R1S
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
239
Blastp_CBE
65.48
55%
-8
- C1 -
-
1VYW
1
CDK2_HUMAN
C:
[6-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
327
Blastp_CBE
65.49
55%
-1
- C1 -
-
3QQG
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
58
Blastp_CBE
65.48
55%
-3
- C1 -
-
4FX3
2
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
260
Blastp_CBE
65.47
55%
-0
- C1 -
-
3S00
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
320
Blastp_CBE
65.42
55%
-1
- C1 -
-
3QTQ
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
354
Blastp_CBE
65.40
55%
-7
- C1 -
-
1OI9
1
CDK2_HUMAN
C:
[4-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
182
Blastp_CBE
65.44
55%
-56
- C1 -
-
1R78
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
162
Blastp_CBE
65.45
55%
-5
- C1 -
-
2C5N
1
CDK2_HUMAN
C:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
325
Blastp_CBE
65.40
55%
-3
- C1 -
-
3QQJ
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
437
Blastp_CBE
65.36
55%
-2
- C1 -
-
4EOL
1
CDK2_HUMAN
A:
[3-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
----
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
256
Blastp_CBE
65.42
55%
-2
- C1 -
-
4EZ3
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
110
Blastp_CBE
65.44
55%
-6
- C1 -
-
2WEV
1
CDK2_HUMAN
C:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
303
Blastp_CBE
65.40
55%
3
- C1 -
-
3QZI
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
142
Blastp_CBE
65.42
55%
-9
- C1 -
-
2I40
1
CDK2_HUMAN
C:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
428
Blastp_CBE
65.41
55%
-59
- C1 -
-
2R3L
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
86
Blastp_CBE
65.40
55%
-1
- C1 -
-
3TIY
12
CDK2_HUMAN
A:
[2-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
405
Blastp_CBE
65.31
55%
-1
- C1 -
-
1H1S
1
CDK2_HUMAN
C:
[5-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
473
Blastp_CBE
65.28
55%
-1
- C1 -
-
3DDP
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
190
Blastp_CBE
65.38
55%
2
- C1 -
-
1PXJ
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
387
Blastp_CBE
65.31
55%
-4
- C1 -
-
3MY5
3
CDK2_HUMAN
A:
[1-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
364
Blastp_CBE
65.31
55%
-5
- C1 -
-
4BCM
1
CDK2_HUMAN
A:
[2-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
409
Blastp_CBE
65.36
55%
-8
- C1 -
-
1H1Q
1
CDK2_HUMAN
C:
[5-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
458
Blastp_CBE
65.25
55%
-6
- C1 -
-
1E9H
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
333
Blastp_CBE
65.34
55%
1
- C1 -
-
3PXY
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
480
Blastp_CBE
65.22
55%
-6
- C1 -
-
1QMZ
1
CDK2_HUMAN
C:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
494
Blastp_CBE
65.32
55%
-5
- C1 -
-
2UZD
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
104
Blastp_CBE
65.31
55%
-8
- C1 -
-
3EJ1
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
401
Blastp_CBE
65.30
55%
-7
- C1 -
-
4CFW
1
CDK2_HUMAN
A:
[4-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
413
Blastp_CBE
65.28
55%
-17
- C1 -
-
4KRC
1
PHO85_YEAST
A:
[7-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
Q
L
E
K
L
G
N
G
T
Y
A
T
V
Y
K
G
L
N
-
K
T
T
G
V
Y
V
A
L
K
E
V
K
L
D
-
S
-
E
-
E
-
G
T
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
---
H
E
N
I
V
R
L
Y
D
V
I
H
------
T
-----
E
------
N
-
K
L
T
L
V
F
E
F
M
D
N
D
L
K
K
Y
M
D
S
R--------
T
PRG
L
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
K
-
R
G
Q
L
K
L
G
D
F
G
L
A
R
A
F
G
I
P
V
N
----
T
F
---
S
S
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
-
G
K
P
L
F
P
G
T
N
D
E
E
Q
L
K
L
I
F
D
I
M
G
T
P
N
E
S
L
W
P
S
--
V
---
T
K
L
P
K
Y
--
N
PNIQQR
P
P
R
D
L
R
-
Q
V
L
-
Q
P
H
--
T
K
E
P
L
D
G
N
L
M
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
--------------------------------------------------
481
Blastp_CBE
65.17
55%
-6
- C1 -
-
1QMZ
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
284
Blastp_CBE
65.24
55%
-2
- C1 -
-
3R8Z
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----------
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
307
Blastp_CBE
65.21
55%
-2
- C1 -
-
3QXP
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
289
Blastp_CBE
65.25
55%
-1
- C1 -
-
3R8L
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
255
Blastp_CBE
65.24
55%
3
- C1 -
-
4EZ7
7
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
253
Blastp_CBE
65.23
55%
-46
- C1 -
-
6GUH
3
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
--------
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
350
Blastp_CBE
65.17
55%
-2
- C1 -
-
6GUB
1
?
C:
[4-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
------
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
192
Blastp_CBE
65.22
55%
-3
- C1 -
-
1PF8
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
225
Blastp_CBE
65.21
55%
-6
- C1 -
-
2WXV
1
CDK2_HUMAN
C:
[6-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
331
Blastp_CBE
65.12
55%
-0
- C1 -
-
3PY0
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
214
Blastp_CBE
65.16
55%
-5
- C1 -
-
1FIN
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
121
Blastp_CBE
65.15
55%
-53
- C1 -
-
2VTQ
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
109
Blastp_CBE
65.12
55%
-4
- C1 -
-
2X1N
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
306
Blastp_CBE
65.08
55%
-3
- C1 -
-
3QZF
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
83
Blastp_CBE
65.12
55%
1
- C1 -
-
3UNJ
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
169
Blastp_CBE
65.11
55%
-1
- C1 -
-
2B54
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
159
Blastp_CBE
65.09
55%
-10
- C1 -
-
2C5V
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
210
Blastp_CBE
65.08
55%
-7
- C1 -
-
1FVV
1
CDK2_HUMAN
C:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
352
Blastp_CBE
65.04
55%
-5
- C1 -
-
1OIY
1
CDK2_HUMAN
C:
[4-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
4
PsiBlast_PDB
65.03
57%
-17
- C1 -
-
1UNG
1
CDK5_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
K
Y
E
K
L
E
K
I
----
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
-
D
-
D
D
E
-
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
H
------
S
-----
D
------
K
-
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
--
N
-
G
D
---
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
---
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
--
M
T
K
L
P
D
Y
K
P
----------
Y
P
M
Y
P
A
T
T
S
L
-
V
N
V
--
V
P
K
-
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------
365
Blastp_CBE
64.97
55%
-6
- C1 -
-
4EOS
1
CDK2_HUMAN
C:
[3-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
134
Blastp_CBE
65.01
55%
-6
- C1 -
-
2UUE
1
CDK2_HUMAN
C:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
410
Blastp_CBE
65.00
55%
-3
- C1 -
-
1H1Q
1
CDK2_HUMAN
A:
[5-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
329
Blastp_CBE
64.97
55%
0
- C1 -
-
3QL8
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
472
Blastp_CBE
64.94
55%
-8
- C1 -
-
3DDP
1
CDK2_HUMAN
C:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
483
Blastp_CBE
64.93
55%
-9
- C1 -
-
1P5E
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
101
Blastp_CBE
64.91
55%
-11
- C1 -
-
3EOC
1
CDK2_HUMAN
C:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
51
Blastp_CBE
64.88
55%
-55
- C1 -
-
5ANG
1
CDK2_HUMAN
A:
[2-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
---------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
485
Blastp_CBE
64.87
55%
-1
- C1 -
-
1GY3
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
102
Blastp_CBE
64.82
55%
-11
- C1 -
-
3EOC
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
186
Blastp_CBE
64.80
55%
3
- C1 -
-
1PXN
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
82
Blastp_CBE
64.80
55%
1
- C1 -
-
3UNK
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
314
Blastp_CBE
64.67
55%
-1
- C1 -
-
3QTZ
3
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
315
Blastp_CBE
64.63
55%
-2
- C1 -
-
3QTX
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
336
Blastp_CBE
64.58
55%
9
- C1 -
-
3PXF
7
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
108
Blastp_CBE
64.57
55%
-4
- C1 -
-
2X1N
1
CDK2_HUMAN
C:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
491
Blastp_CBE
64.45
55%
-5
- C1 -
-
2UZE
1
CDK2_HUMAN
C:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
346
Blastp_CBE
64.50
55%
0
- C1 -
-
6GUF
1
CDK2_HUMAN
C:
[4-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
511
Blastp_CBE
64.49
49%
-54
- C1 -
-
3GC0
1
?
A:
[33-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
Y
R
R
I
T
K
L
G
E
G
T
Y
G
E
V
Y
K
A
I
D
-
T
V
T
N
E
T
V
A
I
K
R
I
R
L
E
-
H
---------
T
A
I
R
E
V
S
L
L
K
E
L
Q
---
H
R
N
I
I
E
L
K
S
V
I
H
------
H
-----
N
------
H
-
R
L
H
L
I
F
E
Y
A
E
N
D
L
K
K
Y
M
D
K
---
N
--
P
-
D
V
----
S
M
R
V
I
K
S
F
L
Y
Q
L
I
N
G
V
N
F
C
H
S
R
R
C
L
H
R
D
L
K
P
Q
N
L
L
L
S
V
E
-
T
P
V
L
K
I
G
D
F
G
L
A
R
A
F
----------------
E
I
I
T
L
W
Y
R
P
P
E
I
L
L
G
S
R
H
Y
S
T
S
V
D
I
W
S
I
A
C
I
W
A
E
M
L
M
-
K
T
P
L
F
P
G
D
S
E
I
D
Q
L
F
K
I
F
E
V
L
G
L
P
D
D
T
T
W
P
G
--
V
T
A
L
P
D
W
K
Q
---
S
------
F
P
K
F
R
G
-
K
T
L
K
R
V
L
--
G
A
L
-
L
D
D
E
G
L
D
L
L
T
A
M
L
E
M
D
P
V
K
R
I
S
A
K
N
A
L
E
H
P
Y
F
--------------------------------------------------
87
Blastp_CBE
64.48
55%
-0
- C1 -
-
3TI1
8
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
55
Blastp_CBE
64.48
55%
-4
- C1 -
-
4LYN
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
457
Blastp_CBE
64.38
55%
-1
- C1 -
-
1E9H
1
CDK2_HUMAN
C:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
185
Blastp_CBE
64.45
55%
-1
- C1 -
-
1PXO
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
183
Blastp_CBE
64.43
55%
-61
- C1 -
-
1PYE
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
---------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
-----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
105
Blastp_CBE
64.43
55%
-4
- C1 -
-
3EID
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
275
Blastp_CBE
64.38
55%
1
- C1 -
-
3RJC
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
502
Blastp_CBE
64.37
55%
-10
- C1 -
-
1JST
1
CDK2_HUMAN
C:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
259
Blastp_CBE
64.36
55%
-2
- C1 -
-
3S0O
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
--
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
317
Blastp_CBE
64.34
55%
-2
- C1 -
-
3QTU
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
503
Blastp_CBE
64.30
55%
-3
- C1 -
-
1JST
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
326
Blastp_CBE
64.28
55%
-1
- C1 -
-
3QQH
4
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
348
Blastp_CBE
64.22
55%
-5
- C1 -
-
6GUE
1
CDK2_HUMAN
C:
[4-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
-------
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
---
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
332
Blastp_CBE
64.18
55%
8
- C1 -
-
3PXZ
3
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
482
Blastp_CBE
64.05
55%
-4
- C1 -
-
1P5E
1
CDK2_HUMAN
C:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
224
Blastp_CBE
64.03
55%
-3
- C1 -
-
3PJ8
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
556
HHSearch
63.94
40%
-108
- C1 -
-
1UA2
1
CDK7_HUMAN
B:
[13-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
-
K
N
T
N
Q
I
V
A
I
K
K
------------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---
H
P
N
I
I
G
L
L
D
A
F
G
------
H
-----
K
------
S
-
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
--
S
-
L
V
---
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
-
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
---
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
P
G
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
--
M
C
S
L
P
D
Y
V
T
F
----------
K
S
F
P
G
-
I
P
L
-
H
H
I
--
F
S
A
-
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
P
----------------------------------------------
46
Blastp_CBE
63.86
55%
-51
- C1 -
-
5FP5
3
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
---------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
257
Blastp_CBE
63.61
55%
-0
- C1 -
-
3SQQ
2
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
------
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
157
Blastp_CBE
63.58
55%
-2
- C1 -
-
2C5X
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
330
Blastp_CBE
63.54
55%
8
- C1 -
-
3PY1
4
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
194
Blastp_CBE
63.48
55%
-60
- C1 -
-
1OIQ
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
---------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
158
Blastp_CBE
63.46
55%
-6
- C1 -
-
2C5V
1
CDK2_HUMAN
C:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
415
Blastp_CBE
63.44
55%
-33
- C1 -
-
2PMI
2
PHO85_YEAST
A:
[19-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
V
Y
K
G
L
N
-
K
T
T
G
V
Y
V
A
L
K
E
V
K
L
D
-
S
-
E
-
E
-
G
T
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
---
H
E
N
I
V
R
L
Y
D
V
I
H
------
T
-----
E
------
N
-
K
L
T
L
V
F
E
F
M
D
N
D
L
K
K
Y
M
D
S
RT-
V
--
G
-
N
T
PRG
L
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
K
-
R
G
Q
L
K
L
G
D
F
G
L
A
R
A
F
G
I
P
V
N
----
T
F
---
S
S
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
T
-
G
K
P
L
F
P
G
T
N
D
E
E
Q
L
K
L
I
F
D
I
M
G
T
P
N
E
S
L
W
P
S
--
V
---
T
K
L
P
K
Y
--
N
PNIQQR
P
P
R
D
L
R
-
Q
V
L
-
Q
P
H
--
T
K
E
P
L
D
G
N
L
M
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
--------------------------------------------------
335
Blastp_CBE
63.33
55%
2
- C1 -
-
3PXQ
4
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
362
Blastp_CBE
63.09
55%
3
- C1 -
-
4BCQ
1
CDK2_HUMAN
A:
[2-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
-----
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
193
Blastp_CBE
63.00
55%
-54
- C1 -
-
1P2A
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
112
Blastp_CBE
62.94
55%
1
- C1 -
-
2W1H
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
177
Blastp_CBE
62.81
55%
-6
- C1 -
-
1WCC
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
47
Blastp_CBE
62.68
55%
-54
- C1 -
-
5D1J
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
-----------------
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
94
Blastp_CBE
62.66
55%
6
- C1 -
-
3LFN
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
----------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
156
Blastp_CBE
62.62
55%
-7
- C1 -
-
2C5X
1
CDK2_HUMAN
C:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
45
Blastp_CBE
62.56
55%
-2
- C1 -
-
5FP6
2
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
504
Blastp_CBE
62.07
55%
-5
- C1 -
-
1FQ1
1
CDK2_HUMAN
B:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
515
Blastp_CBE
62.00
41%
-95
- C1 -
-
1UA2
1
CDK7_HUMAN
A:
[13-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
-
K
N
T
N
Q
I
V
A
I
K
K
------------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---
H
P
N
I
I
G
L
L
D
A
F
G
------
H
-----
K
------
S
-
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
--
S
-
L
V
---
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
-
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
---
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
P
G
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
--
M
C
S
L
P
D
Y
V
T
F
K-
S
------
F
P
G
I
P
L
-
H
H
I
-
F
S
A
--
A
----
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
--------------------------------------------------
512
Blastp_CBE
61.87
41%
-94
- C1 -
-
1UA2
1
CDK7_HUMAN
D:
[13-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
-
K
N
T
N
Q
I
V
A
I
K
K
------------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---
H
P
N
I
I
G
L
L
D
A
F
G
------
H
-----
K
------
S
-
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
--
S
-
L
V
---
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
-
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
---
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
P
G
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
--
M
C
S
L
P
D
Y
V
T
F
K-
S
------
F
P
G
I
P
L
-
H
H
I
-
F
S
A
--
A
----
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
--------------------------------------------------
514
Blastp_CBE
61.81
41%
-97
- C1 -
-
1UA2
1
CDK7_HUMAN
B:
[13-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
-
K
N
T
N
Q
I
V
A
I
K
K
------------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---
H
P
N
I
I
G
L
L
D
A
F
G
------
H
-----
K
------
S
-
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
--
S
-
L
V
---
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
-
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
---
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
P
G
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
--
M
C
S
L
P
D
Y
V
T
F
K-
S
------
F
P
G
I
P
L
-
H
H
I
-
F
S
A
--
A
----
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
--------------------------------------------------
288
Blastp_CBE
61.76
55%
0
- C1 -
-
3R8M
1
CDK2_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
171
Blastp_CBE
61.73
55%
4
- C1 -
-
2B52
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
513
Blastp_CBE
61.47
41%
-95
- C1 -
-
1UA2
1
CDK7_HUMAN
C:
[13-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
-
K
N
T
N
Q
I
V
A
I
K
K
------------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
---
H
P
N
I
I
G
L
L
D
A
F
G
------
H
-----
K
------
S
-
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
--
S
-
L
V
---
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
-
E
-
N
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
----
A
Y
---
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
P
G
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
--
M
C
S
L
P
D
Y
V
T
F
K-
S
------
F
P
G
I
P
L
-
H
H
I
-
F
S
A
--
A
----
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
--------------------------------------------------
426
Blastp_CBE
61.09
55%
-58
- C1 -
-
2R3N
1
CDK2_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
D
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
76
Blastp_CBE
60.90
55%
-52
- C1 -
-
4D1Z
2
CDK2_HUMAN
A:
[3-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
--------------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
367
Blastp_CBE
60.26
55%
-14
- C1 -
-
2IW9
1
CDK2_HUMAN
C:
[4-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
-----------------------------------------
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
341
Blastp_CBE
59.51
55%
3
- C1 -
-
5OO1
1
CDK2_HUMAN
A:
[9-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
434
Blastp_CBE
59.40
55%
-18
- C1 -
-
4EOJ
1
CDK2_HUMAN
C:
[2-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
-----------------------------
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
359
Blastp_CBE
58.71
55%
-22
- C1 -
-
4EOQ
1
CDK2_HUMAN
C:
[2-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
------------------------------------
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
378
Blastp_CBE
58.63
55%
-15
- C1 -
-
4BCO
1
CDK2_HUMAN
C:
[2-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
----------------------------------------
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
452
Blastp_CBE
58.49
55%
-16
- C1 -
-
4EOM
1
CDK2_HUMAN
C:
[2-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
------------------------------------
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
388
Blastp_CBE
58.40
55%
-14
- C1 -
-
3BHV
1
CDK2_HUMAN
C:
[1-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
--------------------------------------
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
373
Blastp_CBE
58.21
55%
-14
- C1 -
-
4CFU
1
CDK2_HUMAN
C:
[4-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
--------------------------------------
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
461
Blastp_CBE
58.11
55%
-20
- C1 -
-
4EOR
1
CDK2_HUMAN
C:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
------------------------------------
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
390
Blastp_CBE
58.00
55%
-13
- C1 -
-
3BHU
1
CDK2_HUMAN
C:
[1-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
--------------------------------------
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
474
Blastp_CBE
57.79
55%
-13
- C1 -
-
2G9X
1
CDK2_HUMAN
C:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
------------------------------------
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
392
Blastp_CBE
57.26
55%
-13
- C1 -
-
3BHT
1
CDK2_HUMAN
C:
[2-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
--------------------------------------
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
355
Blastp_CBE
56.89
55%
-13
- C1 -
-
1OGU
1
CDK2_HUMAN
C:
[2-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
--------------------------------------
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
402
Blastp_CBE
56.67
55%
-19
- C1 -
-
4CFM
1
CDK2_HUMAN
C:
[5-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
---------------------------------------------
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
520
Blastp_CBE
56.17
42%
-22
- C1 -
-
5L2S
1
CDK6_HUMAN
A:
[11-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
----------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
--------------------
T
-
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
--
P
-
E
P
G--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
DV
A
L
P
R
Q
A
F
H
S
K
--
S
-----------
A
-
Q
P
I
-
E
K
F
--
V
T
D
-
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--------------------------------------------------
376
Blastp_CBE
56.15
55%
-13
- C1 -
-
4BCP
1
CDK2_HUMAN
C:
[2-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
--------------------------------------
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
522
Blastp_CBE
55.93
42%
-23
- C1 -
-
4EZ5
1
CDK6_HUMAN
A:
[11-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
------------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
--------------------
T
-
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
--
P
-
E
P
G--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
DV
A
L
P
R
Q
A
F
H
----
S
-----------
A
-
Q
P
I
-
E
K
F
--
V
T
D
-
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--------------------------------------------------
353
Blastp_CBE
55.79
55%
-16
- C1 -
-
1OIU
1
CDK2_HUMAN
C:
[4-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------------------
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
568
HHSearch
55.69
36%
-0
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[6-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
-
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
-
F
-
D
-
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
---
H
D
N
I
I
A
I
K
D
I
L
R
PTVPYG
E
-----
F
------
K
-
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
---
S
----
Q
P
---
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
-
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQY
F
M
---
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
-
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
--
V
G
A
E
-
R
V
R
A
Y
IQ
S
------
L
P
P
R
Q
P
-
V
P
W
-
E
T
V
--
Y
P
G
-
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
--------------------------------------------
470
Blastp_CBE
55.59
55%
-15
- C1 -
-
3DDQ
1
CDK2_HUMAN
C:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------------------
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
468
Blastp_CBE
55.41
55%
-16
- C1 -
-
3DOG
1
CDK2_HUMAN
C:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
---------------------------------------------
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
386
Blastp_CBE
55.40
55%
-17
- C1 -
-
3MY5
1
CDK2_HUMAN
C:
[2-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------------------------------------------
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
561
HHSearch
55.36
36%
1
- C1 -
-
4ZSG
6
MK07_HUMAN
A:
[6-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
-
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
-
F
-
D
V
V
-
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
---
H
D
N
I
I
A
I
K
D
I
L
R
PTVPYG
E
-----
F
------
K
-
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
---
S
----
Q
P
---
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
-
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQY
F
M
---
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
-
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
--
V
G
A
E
R
-
V
R
A
Y
IQ
S
------
L
P
P
R
Q
P
-
V
P
W
-
E
T
V
--
Y
P
G
-
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
--------------------------------------------
521
Blastp_CBE
55.34
42%
-23
- C1 -
-
5L2I
1
CDK6_HUMAN
A:
[11-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
-----------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
--------------------
T
-
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
--
P
-
E
P
G--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
DV
A
L
P
R
Q
A
F
--
K
--
S
-----------
A
-
Q
P
I
-
E
K
F
--
V
T
D
-
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--------------------------------------------------
517
Blastp_CBE
55.32
42%
5
- C1 -
-
2EUF
2
CDK6_HUMAN
B:
[11-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
-
T
G
E
-
E
-
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
T
------
V
SRTDR
E
------
T
-
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
--
P
-
E
P
G--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
-----
A
L
---
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
---------------------------
A
-
Q
P
I
-
E
K
F
--
V
T
D
-
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
-----------------------------------------------
371
Blastp_CBE
55.24
55%
-15
- C1 -
-
4CFV
1
CDK2_HUMAN
C:
[5-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
---------------------------------------------
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
518
Blastp_CBE
55.21
42%
4
- C1 -
-
1XO2
1
CDK6_HUMAN
B:
[11-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
-
T
G
E
-
E
-
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
T
------
V
SR---
E
------
T
-
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
--
P
-
E
P
G--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
-----
A
L
---
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
DV
A
L
P
R
Q
A
F
H
----------------
A
-
Q
P
I
-
E
K
F
--
V
T
D
-
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
-----------------------------------------------
345
Blastp_CBE
55.02
55%
-18
- C1 -
-
2IW8
1
CDK2_HUMAN
C:
[4-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
H
V
D
Q
D
L
K
K
F
M
D
A
---
S
--
A
L
T
G
---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------------------
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
454
Blastp_CBE
55.01
55%
-15
- C1 -
-
5LMK
1
?
C:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-
T
-
E
T
E
-
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------------------
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
524
Blastp_CBE
54.66
42%
-25
- C1 -
-
3NUX
1
CDK6_HUMAN
A:
[11-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
-----------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
--------------------
T
-
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
--
P
-
E
P
G--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
DV
A
L
P
R
Q
A
F
H
-
K
--
S
-----------
A
-
Q
P
I
-
E
K
F
--
V
T
D
-
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--------------------------------------------------
519
Blastp_CBE
54.08
42%
-17
- C1 -
-
5L2T
1
CDK6_HUMAN
A:
[11-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
------------
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
--------------------
T
-
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
--
P
-
E
P
G--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
DV
A
L
P
R
Q
A
F
H
S
K
--
S
-----------
A
-
Q
P
I
-
E
K
F
--
V
T
D
-
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--------------------------------------------------
555
HHSearch
53.81
32%
-18
- C1 -
-
4NM3
5
GSK3B_HUMAN
A:
[54-345]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
-
K
--------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
---
H
C
N
I
V
R
L
R
Y
F
F
Y
------
S
-----
S
KKDE--
V
-
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
YSR
A
--
K
-
Q
T
---
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
-
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
-----
P
N
---
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
--
M
N
P
N
--
Y
T
E
F
--
K
------
F
P
Q
I
K
A
-
H
P
W
T
K
V
F
--
R
P
R
-
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
---------------------------------------------
525
Blastp_CBE
53.52
42%
-31
- C1 -
-
3NUP
1
CDK6_HUMAN
A:
[12-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
E
C
V
A
E
I
G
----
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
-------------
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
T
------
V
--------------
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
--
P
-
E
P
G--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
DV
A
L
P
R
Q
A
F
H
----
S
-----------
A
-
Q
P
I
-
E
K
F
--
V
T
D
-
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--------------------------------------------------
558
HHSearch
53.35
32%
-13
- C1 -
-
1J1B
1
GSK3B_HUMAN
A:
[54-345]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
-
K
--------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
---
H
C
N
I
V
R
L
R
Y
F
F
Y
------
S
-----
S
GEKKDE
V
-
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
YSR
A
--
K
-
Q
T
---
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
-
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
-----
P
N
---
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
--
M
N
P
N
--
Y
T
E
F
--
K
------
F
P
Q
I
K
A
-
H
P
W
T
K
V
F
--
R
P
R
-
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
---------------------------------------------
523
Blastp_CBE
53.13
42%
-17
- C1 -
-
4AUA
1
CDK6_HUMAN
A:
[11-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
---------------
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
--------------------
T
-
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
--
P
-
E
P
G--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
----------------------
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
DV
A
L
P
R
Q
A
F
H
S
K
--
S
-----------
A
-
Q
P
I
-
E
K
F
--
V
T
D
-
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--------------------------------------------------
516
Blastp_CBE
52.33
42%
8
- C1 -
-
2F2C
2
CDK6_HUMAN
B:
[11-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
-
A
E
I
G
----
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
Q
-
T
G
E
-
E
-
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
T
------
V
STDR-
E
------
T
-
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
--
P
-
E
P
G--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
-----
A
L
---
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
-------
Q
A
F
-----------------
A
-
Q
P
I
-
E
K
F
--
V
T
D
-
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
-----------------------------------------------
526
Blastp_CBE
49.33
42%
-11
- C1 -
-
4TTH
1
CDK6_HUMAN
B:
[15-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
V
A
E
I
G
E
----
K
V
F
K
A
R
D
L
K
N
-
G
R
F
V
A
L
K
R
V
R
V
------
E
-
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
T
-------------------
T
-
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
---
V
--
P
-
E
P
G--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
-
Q
M
----
A
L
---
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
S
-
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
-
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
------------------------------
P
I
-
E
K
F
----
D
-
I
D
E
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
D
L
-----------------------------------------------
530
Blastp_CBE
48.10
40%
-0
- C1 -
-
4BCF
1
CDK9_HUMAN
A:
[16-318]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
-
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
-
N
-
E
K
E
-
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
L
L
K
---
H
E
N
V
V
N
L
I
E
I
C
R
------
T
-----
K
------
A
-
S
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
N
---
V
--
L
-
V
K
---
F
T
L
S
E
I
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
-
R
-
D
G
V
L
K
L
A
D
F
G
L
A
R
A
F
S
L
---------PNR
Y
N
R
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
-
R
S
P
I
M
Q
G
N
T
E
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
--
V
D
N
Y
E
L
Y
E
K
L
--
E
------
L
V
K
G
Q
K
-
R
K
V
-
K
D
R
LK
A
Y
V
-
R
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
R
I
D
S
D
D
A
L
N
H
D
F
F
W
S
------------------------------------------------
451
Blastp_CBE
47.15
55%
-3
- C1 -
-
1H01
3
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
-
I
R
---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
529
Blastp_CBE
46.33
38%
22
- C1 -
-
5EFQ
2
CDK13_HUMAN
A:
[3-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
W
G
K
RC
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
R
D
-
K
D
T
G
E
M
V
A
L
K
K
V
R
L
D
-
N
-
E
K
E
-
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
T
---
H
Q
S
I
I
N
M
K
E
I
V
T
------
D
-----
K
------
E
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
---
G
--
L
-
V
H
---
F
N
E
N
H
I
K
S
F
M
R
Q
L
M
E
G
L
D
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
-
N
-
R
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
S
S
E
E
S
----
R
P
---
Y
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
-
K
K
P
I
F
Q
A
N
Q
E
L
A
Q
L
E
L
I
S
R
I
C
G
S
P
C
P
A
V
W
P
D
--
V
I
K
L
P
Y
F
N
T
M
--
K
------
P
K
K
Q
Y
R
-
R
K
L
-
R
E
E
--
F
V
F
-
I
P
A
A
A
L
D
L
F
D
Y
M
L
A
L
D
P
S
K
R
C
T
A
E
Q
A
L
Q
C
E
F
L
--------------------------------------------------
450
Blastp_CBE
45.80
55%
1
- C1 -
-
1OIR
1
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
-
I
R
---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
H
------
T
-----
E
------
N
-
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
--
A
-
L
T
G--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--
V
T
S
M
P
D
Y
K
P
---
S
------
F
P
K
W
A
R
-
Q
D
F
-
S
K
V
--
V
P
P
-
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------
528
Blastp_CBE
45.45
38%
23
- C1 -
-
5EFQ
2
C:
[5-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
W
G
K
RC
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
R
D
-
K
D
T
G
E
M
V
A
L
K
K
V
R
L
D
-
N
-
E
K
E
-
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
T
---
H
Q
S
I
I
N
M
K
E
I
V
T
------
D
-----
K
------
E
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
---
G
--
L
-
V
H
---
F
N
E
N
H
I
K
S
F
M
R
Q
L
M
E
G
L
D
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
-
N
-
R
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
S
S
E
E
S
----
R
P
---
Y
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
-
K
K
P
I
F
Q
A
N
Q
E
L
A
Q
L
E
L
I
S
R
I
C
G
S
P
C
P
A
V
W
P
D
--
V
I
K
L
P
Y
F
N
T
M
--
K
------
P
K
K
Q
Y
R
-
R
K
L
-
R
E
E
--
F
V
F
-
I
P
A
A
A
L
D
L
F
D
Y
M
L
A
L
D
P
S
K
R
C
T
A
E
Q
A
L
Q
C
E
F
L
--------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------