@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDKL2_HUMAN: (2020-09-06 )
MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQELQLKVQKDARNVSLSKKSQNRKKEKEKDDSLVEERKTLVVQDTNADPKIKDYKLFKIKGSKIDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRNPSVAIPPLTHNLSAVAPSINSGMGTETIPIQGYRVDEKTKKCSIPFVKPNRHSPSGIYNINVTTLVSGPPLSDDSGADLPQMEHQH
Atome Classification :
(492 SA)
.........10........20..-......30........40........50........---60........70---------.------..----......80....---..---..90..---.---------.-.-----.--..100.......110.......120.......130...-.-...140.......150....----...160.......170.......180.......190....-...200.......210.......----220---........230......-.-240----..------.....-250---...------------....----260------.........270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEKYENL
G
L
VGEGSY
G
M
V
M
K
CRN-KDTG
R
I
V
A
I
K
K
F
L
ESD
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
---
H
E
N
L
V
N
L
L
E
V
C
----------
K
------KK----K
R
W
Y
L
V
F
E
F
V
D
H
---
T
I
---
L
D
D
L
E
L---F---------P-N-----G--L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
IGFCHSHN
I
I
HRDIKPE
N
I
L
VS-Q-SG
V
V
K
L
CDFG
F
A
R
TLAAP
G
E
----
V
Y
T
D
Y
V
A
T
R
WYRAPE
L
L
V
GDVKYG
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F-MGEPLFPGDS
D
I
D
Q
L
Y
H
I
M
M
C
L
G
----
N
L----I
P
R
H
Q
E
L
FNKNPVFAGV-R-LPE----IK------ERE
P
L
-
E
R
R---Y
P
K
------------
L
S
E
V
----
V
--------
I
D
L
A
K
K
C
LHIDPDKR
P
F
C
A
E
L
L
H
H
D
F
F
QM
D
G
F
A
E
R
F
S
Q
E
L
Q
L
K
V
QKDARNVSLSKKSQNRKKEKEK
D
D
S
L
V
E
ER
K
T
L
V
V
Q
DTNADPKIK
D
Y
K
L
F
K
I
KGSKIDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRNPSVAIPPLTH
N
L
S
AVAPSINSGMGTE
T
I
P
IQ
G
Y
RVDEKTKKCSIPFVKPNRHSPS
G
I
Y
N
I
N
V
T
T
L
VSGPPLSDDSGADLPQMEHQH
2
PsiBlast_PDB
95.26
99%
-147
- C3 -
-
4BBM
3
CDKL2_HUMAN
A:
[24-331]
M
E
K
Y
E
N
L
G
L
V
--
G
S
Y
G
M
V
M
K
C
R
N
-
K
D
T
G
R
I
V
A
I
K
K
F
L
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
---
H
E
N
L
V
N
L
L
E
V
C
----------
K
------
K
K
----
K
R
W
Y
L
V
F
E
F
V
D
H
---
T
I
---
L
D
D
L
E
L
---
F
---------
P
-
N
-----
G
--
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
-
Q
-
S
G
V
V
K
L
C
D
F
G
F
A
R
T
L
A
A
P
G
E
----
V
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
-
M
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
----
N
L
----
I
P
R
H
Q
E
L
F
N
K
N
P
V
F
A
G
V
-
R
-
L
P
E
----
I
K
------
E
R
E
P
L
-
E
R
R
---
Y
P
K
------------
L
S
E
V
----
V
--------
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
K
V
Q
K
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
536
HHSearch
94.83
99%
-148
- C3 -
-
4BBM
3
CDKL2_HUMAN
A:
[25-330]
-
E
K
Y
E
N
L
G
L
V
G
--
S
Y
G
M
V
M
K
C
R
N
-
K
D
T
G
R
I
V
A
I
K
K
F
L
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
---
H
E
N
L
V
N
L
L
E
V
C
----------
K
------
K
K
----
K
R
W
Y
L
V
F
E
F
V
D
H
---
T
I
---
L
D
D
L
E
L
---
F
---------
P
-
N
-----
G
--
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
-
Q
-
S
G
V
V
K
L
C
D
F
G
F
A
R
T
L
A
A
P
G
E
----
V
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
-
M
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
----
N
L
----
I
P
R
H
Q
E
L
F
N
K
N
P
V
F
A
G
V
-
R
-
L
P
E
----
I
K
------
E
R
E
P
L
-
E
R
R
---
Y
P
K
------------
L
S
E
V
----
V
--------
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
K
V
Q
K
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
93.48
99%
-166
- C3 -
-
4AAA
7
CDKL2_HUMAN
A:
[24-325]
M
E
K
Y
E
N
L
G
L
V
G
E
G
S
Y
G
M
V
M
K
C
R
N
-
K
D
T
G
R
I
V
A
I
K
K
F
L
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
---
H
E
N
L
V
N
L
L
E
V
C
----------
K
------
K
K
----
K
R
W
Y
L
V
F
E
F
V
D
H
---
T
I
---
L
D
D
L
E
L
---
F
---------
P
-
N
-----
G
--
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
-
Q
-
S
G
V
V
K
L
C
D
F
G
F
A
----------------
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
-
M
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
----
N
L
----
I
P
R
H
Q
E
L
F
N
K
N
P
V
F
A
G
V
-
R
-
L
P
E
----
I
K
------
E
R
E
P
L
-
E
R
R
---
Y
P
K
------------
L
S
E
V
----
V
--------
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
537
HHSearch
93.05
99%
-164
- C3 -
-
4AAA
7
CDKL2_HUMAN
A:
[25-325]
-
E
K
Y
E
N
L
G
L
V
G
E
G
S
Y
G
M
V
M
K
C
R
N
-
K
D
T
G
R
I
V
A
I
K
K
F
L
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
---
H
E
N
L
V
N
L
L
E
V
C
----------
K
------
K
K
----
K
R
W
Y
L
V
F
E
F
V
D
H
---
T
I
---
L
D
D
L
E
L
---
F
---------
P
-
N
-----
G
--
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
-
Q
-
S
G
V
V
K
L
C
D
F
G
F
A
----------------
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
-
M
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
----
N
L
----
I
P
R
H
Q
E
L
F
N
K
N
P
V
F
A
G
V
-
R
-
L
P
E
----
I
K
------
E
R
E
P
L
-
E
R
R
---
Y
P
K
------------
L
S
E
V
----
V
--------
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
90.84
99%
-151
- C3 -
-
4BBM
3
CDKL2_HUMAN
B:
[24-331]
M
E
K
Y
E
N
L
-----
G
S
Y
G
M
V
M
K
C
R
N
-
K
D
T
G
R
I
V
A
I
K
K
F
---------
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
---
H
E
N
L
V
N
L
L
E
V
C
--------------------------
Y
L
V
F
E
F
V
D
H
---
T
I
---
L
D
D
L
E
L
---
F
---------
P
-
N
-----
G
--
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
-
Q
-
S
G
V
V
K
L
C
D
F
G
F
A
R
T
L
A
A
P
G
E
----
V
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
-
M
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
----
N
L
----
I
P
R
H
Q
E
L
F
N
K
N
P
V
F
A
G
V
-
R
-
L
P
E
----
I
K
------
E
R
E
P
L
-
E
R
R
---
Y
P
K
------------
L
S
E
V
----
V
--------
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
L
K
V
Q
K
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
539
HHSearch
82.46
57%
-132
- C3 -
-
3ZDU
3
CDKL3_HUMAN
A:
[2-310]
M
E
M
Y
E
T
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
-
K
N
T
G
Q
I
V
A
I
K
I
F
Y
--------
N
K
I
A
M
R
E
I
K
F
L
K
Q
F
H
---
H
E
N
L
V
N
L
I
E
V
F
----------
R
------
Q
K
----
K
K
I
H
L
V
F
E
F
I
D
H
---
T
V
---
L
D
E
L
Q
H
---
Y
---------
C
-
H
-----
G
--
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
-
Q
-
S
G
I
T
K
L
C
D
F
G
F
A
R
T
-----
D
----
I
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
V
L
K
D
T
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
-
T
G
N
P
Y
L
P
S
S
S
D
L
D
L
L
H
K
I
V
L
K
V
G
----
N
L
----
S
P
H
L
Q
N
I
F
S
K
S
P
I
F
A
G
V
-
V
-
L
P
Q
----
V
Q
------
H
P
K
N
A
-
R
K
K
---
Y
P
K
------------
L
N
G
L
----
L
--------
A
D
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
T
R
D
G
F
I
E
K
F
M
P
E
L
K
A
K
L
L
Q
E
A
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
82.24
56%
-132
- C3 -
-
3ZDU
3
CDKL3_HUMAN
A:
[2-310]
M
E
M
Y
E
T
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
-
K
N
T
G
Q
I
V
A
I
K
I
F
Y
--------
N
K
I
A
M
R
E
I
K
F
L
K
Q
F
H
---
H
E
N
L
V
N
L
I
E
V
F
----------
R
------
Q
K
----
K
K
I
H
L
V
F
E
F
I
D
H
---
T
V
---
L
D
E
L
Q
H
---
Y
---------
C
-
H
-----
G
--
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
-
Q
-
S
G
I
T
K
L
C
D
F
G
F
A
R
T
-----
D
----
I
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
V
L
K
D
T
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
-
T
G
N
P
Y
L
P
S
S
S
D
L
D
L
L
H
K
I
V
L
K
V
G
----
N
L
----
S
P
H
L
Q
N
I
F
S
K
S
P
I
F
A
G
V
-
V
-
L
P
Q
----
V
Q
------
H
P
K
N
A
-
R
K
K
---
Y
P
K
------------
L
N
G
L
----
L
--------
A
D
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
T
R
D
G
F
I
E
K
F
M
P
E
L
K
A
K
L
L
Q
E
A
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
78.11
57%
-143
- C3 -
-
4AGU
1
CDKL1_HUMAN
A:
[3-289]
-
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
-
R
D
T
G
Q
I
V
A
I
K
K
F
L
E
S
E
-
D
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
---
H
P
N
L
V
N
L
L
E
V
F
----------
R
------
R
K
----
R
R
L
H
L
V
F
E
Y
C
D
H
---
T
V
---
L
H
E
L
D
R
---
Y
---------
Q
-
R
-----
G
--
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
-
K
-
H
S
V
I
K
L
C
D
F
G
F
A
R
L
L
----------------
T
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
-
S
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
----
D
L
----
I
P
R
H
Q
Q
V
F
S
T
N
Q
Y
F
S
G
V
-
K
-
I
P
D
----
P
E
------
D
M
E
P
L
-
E
L
K
---
F
P
N
------------
I
S
Y
P
----
A
--------
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
550
HHSearch
78.06
57%
-142
- C3 -
-
4AGU
1
CDKL1_HUMAN
C:
[3-291]
-
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
-
R
D
T
G
Q
I
V
A
I
K
K
F
L
E
S
E
D
D
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
---
H
P
N
L
V
N
L
L
E
V
F
----------
R
------
R
K
----
R
R
L
H
L
V
F
E
Y
C
D
H
---
T
V
---
L
H
E
L
D
R
---
Y
---------
Q
-
R
-----
G
--
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
-
K
-
H
S
V
I
K
L
C
D
F
G
F
A
R
L
L
----------------
T
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
-
S
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
----
D
L
----
I
P
R
H
Q
Q
V
F
S
T
N
Q
Y
F
S
G
V
-
K
-
I
P
D
----
P
E
------
D
M
E
P
L
-
E
L
K
---
F
P
N
------------
I
S
Y
P
----
A
--------
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
77.55
58%
-146
- C3 -
-
4AGU
1
CDKL1_HUMAN
B:
[4-289]
--
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
-
R
D
T
G
Q
I
V
A
I
K
K
F
L
E
S
--
D
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
---
H
P
N
L
V
N
L
L
E
V
F
----------
R
------
R
K
----
R
R
L
H
L
V
F
E
Y
C
D
H
---
T
V
---
L
H
E
L
D
R
---
Y
---------
Q
-
R
-----
G
--
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
-
K
-
H
S
V
I
K
L
C
D
F
G
F
A
R
L
L
----------------
T
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
-
S
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
----
D
L
----
I
P
R
H
Q
Q
V
F
S
T
N
Q
Y
F
S
G
V
-
K
-
I
P
D
----
P
E
------
D
M
E
P
L
-
E
L
K
---
F
P
N
------------
I
S
Y
P
----
A
--------
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
77.55
58%
-143
- C3 -
-
4AGU
1
CDKL1_HUMAN
C:
[3-289]
-
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
-
R
D
T
G
Q
I
V
A
I
K
K
F
L
E
S
E
D
D
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
---
H
P
N
L
V
N
L
L
E
V
F
----------
R
------
R
K
----
R
R
L
H
L
V
F
E
Y
C
D
H
---
T
V
---
L
H
E
L
D
R
---
Y
---------
Q
-
R
-----
G
--
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
-
K
-
H
S
V
I
K
L
C
D
F
G
F
A
R
L
L
----------------
T
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
-
S
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
----
D
L
----
I
P
R
H
Q
Q
V
F
S
T
N
Q
Y
F
S
G
V
-
K
-
I
P
D
----
P
E
------
D
M
E
P
L
-
E
L
K
---
F
P
N
------------
I
S
Y
P
----
A
--------
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
495
Blastp_CBE
72.71
40%
-136
- C3 -
-
3NIZ
1
?
A:
[20-305]
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
-
S
Q
-
G
R
I
V
A
L
K
R
I
R
------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
---
H
P
N
I
V
S
L
I
D
V
I
----------
H
------
S
E
----
R
C
L
T
L
V
F
E
F
M
E
K
---
D
L
---
K
K
V
L
D
E
---
N
---------
K
-
T
-----
G
--
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
S
-
D
G
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
-------
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
-
T
G
K
P
L
F
P
G
V
T
D
D
D
Q
L
P
K
I
F
S
I
L
G
----
T
P
----
N
P
R
E
W
P
Q
V
Q
E
L
P
L
W
K
Q
--
R
-
T
F
Q
----
V
F
------
E
K
K
P
W
-
S
S
I
---
I
P
G
------------
F
C
Q
E
----
G
--------
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
548
HHSearch
70.37
48%
-123
- C3 -
-
4BGQ
3
CDKL5_HUMAN
A:
[11-300]
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
-
K
E
T
H
E
I
V
A
I
K
K
F
K
-------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
---
Q
E
N
I
V
E
L
K
E
A
F
----------
R
------
R
R
----
G
K
L
Y
L
V
F
E
Y
V
E
K
---
N
M
---
L
E
L
L
E
E
---
M
---------
P
-
N
-----
G
--
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
-
H
-
N
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
--------------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
-
D
G
Q
P
L
F
P
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
L
G
----
P
L
----
P
S
E
Q
M
K
L
F
Y
S
N
P
R
F
H
G
L
-
R
-
F
P
A
----
V
N
------
H
P
Q
S
L
E
R
R
Y
---
L
G
I
------------
L
N
S
V
----
L
--------
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
70.20
48%
-122
- C3 -
-
4BGQ
3
CDKL5_HUMAN
A:
[11-299]
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
-
K
E
T
H
E
I
V
A
I
K
K
F
K
-------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
---
Q
E
N
I
V
E
L
K
E
A
F
----------
R
------
R
R
----
G
K
L
Y
L
V
F
E
Y
V
E
K
---
N
M
---
L
E
L
L
E
E
---
M
---------
P
-
N
-----
G
--
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
-
H
-
N
D
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
--------------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
-
D
G
Q
P
L
F
P
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
L
G
----
P
L
----
P
S
E
Q
M
K
L
F
Y
S
N
P
R
F
H
G
L
-
R
-
F
P
A
----
V
N
------
H
P
Q
S
L
-
E
R
R
---
Y
L
G
I-----------
L
N
S
V
----
L
--------
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
531
Blastp_CBE
68.70
34%
-119
- C3 -
-
5G6V
4
CDK16_HUMAN
A:
[1-285]
M
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
-
K
L
T
D
N
L
V
A
L
K
E
-
I
R
L
E
H
E
E
G
A
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
I
----------
H
------
T
E
----
K
S
L
T
L
V
F
E
Y
L
D
K
---
D
L
---
K
Q
Y
L
D
D
---
C
---------
G
-
N
-----
I
--
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
A
-----
K
----
T
Y
D
N
E
V
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
-
T
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
----
T
P
----
T
E
E
T
W
P
G
I
L
S
N
E
E
F
K
T
Y
-
N
-
Y
P
K
----
Y
R
------
A
-
E
A
L
-
L
S
H
---
A
P
R
------------
L
D
S
D
----
G
--------
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
530
Blastp_CBE
68.69
34%
-135
- C3 -
-
5G6V
3
CDK16_HUMAN
B:
[1-285]
M
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
-
K
L
T
D
N
L
V
A
L
K
E
-
I
R
L
E
H
E
E
G
A
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
I
----------
H
------
T
E
----
K
S
L
T
L
V
F
E
Y
L
D
K
---
D
L
---
K
Q
Y
L
D
D
---
C
---------
G
-
N
-----
I
--
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
A
----------------
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
-
T
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
----
T
P
----
T
E
E
T
W
P
G
I
L
S
N
E
E
F
K
T
Y
-
N
-
Y
P
K
----
Y
R
------
A
-
E
A
L
-
L
S
H
---
A
P
R
------------
L
D
S
D
----
G
--------
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
500
Blastp_CBE
68.37
39%
-107
- C3 -
-
1V0P
1
CDC2H_PLAFK
A:
[1-285]
M
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
--
N
Y
G
E
T
F
A
L
K
K
I
R
L
E
K
E
D
E
G
I
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
I
----------
H
------
T
K
----
K
R
L
V
L
V
F
E
H
L
D
Q
---
D
L
---
K
K
L
L
D
V
---
C
---------
E
-
G
-----
G
--
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
-------------
I
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
----
T
P
NSKN
W
P
N
V
T
E
L
P
K
Y
D
P
N
F
T
------------
V
Y
------
E
P
L
P
W
-
E
S
F
---
L
K
G
------------
L
D
E
S
----
G
--------
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
502
Blastp_CBE
68.35
39%
-96
- C3 -
-
1UNL
1
CDK5_HUMAN
A:
[1-286]
M
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
----------
H
------
S
D
----
K
K
L
T
L
V
F
E
F
C
D
Q
---
D
L
---
K
K
Y
F
D
S
---
C
---------
N
-
G
-----
D
--
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
----
T
P
----
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
Y
----
P
M
----
Y
P
------
A
T
T
S
L
-
V
N
V
---
V
P
K
------------
L
N
A
T
----
G
--------
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
67.19
39%
-95
- C3 -
-
4AU8
2
CDK5_HUMAN
B:
[6-290]
-
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
L
----
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
----------
H
------
S
-----
K
K
L
T
L
V
F
E
F
C
D
Q
---
D
L
---
K
K
Y
F
D
S
---
C
---------
N
-
G
-----
D
--
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
----------
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
----
T
P
----
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
Y
----
P
M
----
Y
P
------
A
T
T
S
L
-
V
N
V
---
V
P
K
------------
L
N
A
T
----
G
--------
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
66.76
41%
-75
- C3 -
-
2R3O
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
----------
D
L
K
K
---
F
---------
M
-
D
ASALT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
508
Blastp_CBE
66.44
39%
-90
- C3 -
-
4AU8
2
CDK5_HUMAN
A:
[6-290]
-
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
---------
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
----------
H
-------------
K
L
T
L
V
F
E
F
C
D
Q
---
D
L
---
K
K
Y
F
D
S
---
C
---------
N
-
G
-----
D
--
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
------
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
----
T
P
----
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
Y
----
P
M
----
Y
P
------
A
T
T
S
L
-
V
N
V
---
V
P
K
------------
L
N
A
T
----
G
--------
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
66.29
39%
-92
- C3 -
-
1V0O
1
CDC2H_PLAFK
A:
[3-285]
--
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
--
N
Y
G
E
T
F
A
L
K
K
I
R
L
--------
S
T
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
I
----------
H
------
T
K
----
K
R
L
V
L
V
F
E
H
L
D
Q
---
D
L
---
K
K
L
L
D
V
---
C
---------
E
-
G
-----
G
--
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
K
Y
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
----
T
P
NSKN
W
P
N
V
T
E
L
P
K
Y
D
P
N
F
T
------------
V
Y
------
E
P
L
P
W
-
E
S
F
---
L
K
G
------------
L
D
E
S
----
G
--------
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
66.08
41%
-76
- C3 -
-
2R3P
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
----------
D
L
K
K
---
F
---------
M
-
D
ASALT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
65.93
41%
-71
- C3 -
-
1W8C
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
----------
D
L
K
K
---
F
---------
M
-
D
ASALT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
65.86
41%
-73
- C3 -
-
2R3I
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
----------
D
L
K
K
---
F
---------
M
-
D
ASALT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
497
Blastp_CBE
65.82
39%
-87
- C3 -
-
1V0O
1
CDC2H_PLAFK
B:
[3-285]
--
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
--
N
Y
G
E
T
F
A
L
K
K
I
R
L
----------
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
I
----------
H
------
T
K
----
K
R
L
V
L
V
F
E
H
L
D
Q
---
D
L
---
K
K
L
L
D
V
---
C
---------
E
-
G
-----
G
--
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
K
Y
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
----
T
P
NSKN
W
P
N
V
T
E
L
P
K
Y
D
P
N
F
T
------------
V
Y
------
E
P
L
P
W
-
E
S
F
---
L
K
G
------------
L
D
E
S
----
G
--------
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Blastp_CBE
65.76
41%
-47
- C3 -
-
4KD1
2
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
202
Blastp_CBE
65.72
41%
-44
- C3 -
-
1FVV
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
65.66
41%
-46
- C3 -
-
2EXM
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
65.63
41%
-74
- C3 -
-
2R3Q
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
----------
D
L
K
K
---
F
---------
M
-
D
ASALT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
314
Blastp_CBE
65.52
41%
-50
- C3 -
-
3PXY
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
152
Blastp_CBE
65.47
41%
-44
- C3 -
-
2C5O
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
167
Blastp_CBE
65.43
41%
-52
- C3 -
-
1Y8Y
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
65.39
41%
-54
- C3 -
-
2C6K
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
65.37
41%
-42
- C3 -
-
2C5N
1
CDK2_HUMAN
C:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
65.26
41%
-50
- C3 -
-
3R1S
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
65.25
41%
-47
- C3 -
-
4FX3
2
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
224
Blastp_CBE
65.22
41%
-51
- C3 -
-
6Q4H
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
65.23
41%
-51
- C3 -
-
3PY0
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
65.22
41%
-53
- C3 -
-
3UNJ
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
506
Blastp_CBE
65.21
39%
-102
- C3 -
-
1UNG
1
CDK5_HUMAN
A:
[1-286]
M
Q
K
Y
E
K
L
E
K
I
----
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
----------
H
------
S
D
----
K
K
L
T
L
V
F
E
F
C
D
Q
---
D
L
---
K
K
Y
F
D
S
---
C
---------
N
-
G
-----
D
--
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
----
T
P
----
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
Y
----
P
M
----
Y
P
------
A
T
T
S
L
-
V
N
V
---
V
P
K
------------
L
N
A
T
----
G
--------
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
65.19
41%
-57
- C3 -
-
3QQJ
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
Blastp_CBE
65.16
41%
-43
- C3 -
-
2X1N
1
CDK2_HUMAN
C:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
182
Blastp_CBE
65.13
41%
-56
- C3 -
-
1PXI
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
164
Blastp_CBE
65.13
41%
-49
- C3 -
-
2A0C
1
CDK2_HUMAN
X:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
65.11
41%
-44
- C3 -
-
4FX3
1
CDK2_HUMAN
C:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
65.09
41%
-49
- C3 -
-
3S00
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
65.08
41%
-49
- C3 -
-
1YKR
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
175
Blastp_CBE
65.07
41%
-53
- C3 -
-
1PXP
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
65.02
41%
-48
- C3 -
-
3PY1
4
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
65.02
41%
-49
- C3 -
-
3QQG
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
65.00
41%
-51
- C3 -
-
3RPO
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
65.02
41%
-40
- C3 -
-
2UUE
1
CDK2_HUMAN
C:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
64.96
41%
-47
- C3 -
-
2BKZ
1
CDK2_HUMAN
A:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
65.00
41%
-55
- C3 -
-
2C6O
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
64.99
41%
-52
- C3 -
-
2V0D
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
277
Blastp_CBE
64.96
41%
-52
- C3 -
-
3R73
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
64.95
41%
-50
- C3 -
-
3R7Y
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
279
Blastp_CBE
64.94
41%
-51
- C3 -
-
3R6X
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
64.92
41%
-54
- C3 -
-
3TIZ
9
CDK2_HUMAN
A:
[2-287]
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
64.90
41%
-53
- C3 -
-
5ANE
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
177
Blastp_CBE
64.89
41%
-47
- C3 -
-
1PXN
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
64.84
41%
-53
- C3 -
-
3QQF
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
Blastp_CBE
64.87
41%
-48
- C3 -
-
2XMY
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
---
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
64.86
41%
-51
- C3 -
-
3QTZ
3
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
301
Blastp_CBE
64.85
41%
-47
- C3 -
-
3QTQ
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
235
Blastp_CBE
64.84
41%
-47
- C3 -
-
4GCJ
5
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
276
Blastp_CBE
64.83
41%
-52
- C3 -
-
3R7E
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
305
Blastp_CBE
64.82
41%
-48
- C3 -
-
3QQK
6
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
64.81
41%
-48
- C3 -
-
2WXV
1
CDK2_HUMAN
A:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
64.79
41%
-58
- C3 -
-
1PXO
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
161
Blastp_CBE
64.76
41%
-52
- C3 -
-
2B53
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
499
Blastp_CBE
64.75
39%
-108
- C3 -
-
1V0P
1
CDC2H_PLAFK
B:
[2-285]
-
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
--
N
Y
G
E
T
F
A
L
K
-----------
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
I
----------
H
------
T
-------
L
V
L
V
F
E
H
L
D
Q
---
D
L
---
K
K
L
L
D
V
---
C
---------
E
-
G
-----
G
--
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
A
F
-----------------
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
----
T
P
NSKN
W
P
N
V
T
E
L
P
K
Y
D
P
N
F
T
------------
V
Y
------
E
P
L
P
W
-
E
S
F
---
L
K
G
------------
L
D
E
S
----
G
--------
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
194
Blastp_CBE
64.74
41%
-60
- C3 -
-
1H0W
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
64.72
41%
-53
- C3 -
-
1PXJ
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
64.71
41%
-51
- C3 -
-
3R8U
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
64.68
41%
-47
- C3 -
-
2C68
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
64.68
41%
-56
- C3 -
-
2UZO
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
64.62
41%
-45
- C3 -
-
2BKZ
1
CDK2_HUMAN
C:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
64.66
41%
-49
- C3 -
-
2WIH
1
CDK2_HUMAN
C:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
64.62
41%
-43
- C3 -
-
3PXZ
3
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
64.58
41%
-49
- C3 -
-
3QXO
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
64.54
41%
-47
- C3 -
-
3R9D
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
64.56
41%
-42
- C3 -
-
2C5O
1
CDK2_HUMAN
C:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
64.51
41%
-53
- C3 -
-
3R8V
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
64.52
41%
-51
- C3 -
-
6Q4C
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
283
Blastp_CBE
64.53
41%
-53
- C3 -
-
3R1Q
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
64.52
41%
-43
- C3 -
-
2C5N
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
64.48
41%
-48
- C3 -
-
3QTX
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
Blastp_CBE
64.51
41%
-39
- C3 -
-
2X1N
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
317
Blastp_CBE
64.49
41%
-41
- C3 -
-
3PXF
7
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
64.48
41%
-51
- C3 -
-
3QZG
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
64.47
41%
-53
- C3 -
-
2C6I
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
64.41
41%
-46
- C3 -
-
2C4G
1
CDK2_HUMAN
A:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
64.41
41%
-54
- C3 -
-
3RAI
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
64.43
42%
-55
- C3 -
-
6Q4G
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
E
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
64.42
41%
-50
- C3 -
-
3QQH
4
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
237
Blastp_CBE
64.41
41%
-53
- C3 -
-
4EZ3
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
64.34
41%
-46
- C3 -
-
2WIH
1
CDK2_HUMAN
A:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Blastp_CBE
64.36
41%
-42
- C3 -
-
2WEV
1
CDK2_HUMAN
C:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
270
Blastp_CBE
64.32
41%
-51
- C3 -
-
3R8L
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
64.34
41%
-51
- C3 -
-
3QX4
3
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
64.30
41%
-51
- C3 -
-
3QZI
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
64.33
41%
-48
- C3 -
-
3UNK
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
64.32
41%
-47
- C3 -
-
2B54
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
64.30
41%
-41
- C3 -
-
2C5V
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
64.29
41%
-49
- C3 -
-
3R7V
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
338
Blastp_CBE
64.28
41%
-47
- C3 -
-
6Q4F
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
64.21
41%
-45
- C3 -
-
1VYW
1
CDK2_HUMAN
A:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
64.26
41%
-44
- C3 -
-
1FIN
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
64.22
41%
-47
- C3 -
-
3QU0
5
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
64.22
41%
-52
- C3 -
-
3R71
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
64.22
41%
-46
- C3 -
-
1FVV
1
CDK2_HUMAN
C:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
64.21
41%
-50
- C3 -
-
3QZF
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
64.19
41%
-51
- C3 -
-
3LFN
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
-------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
64.13
41%
-50
- C3 -
-
6Q3C
1
CDK2_HUMAN
A:
[10-295]
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
64.11
41%
-49
- C3 -
-
1HCK
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
64.10
41%
-41
- C3 -
-
3QRU
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
Blastp_CBE
64.09
41%
-50
- C3 -
-
3F5X
2
CDK2_HUMAN
C:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
63.97
41%
-45
- C3 -
-
2BPM
1
CDK2_HUMAN
A:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
64.00
41%
-56
- C3 -
-
3PJ8
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
63.97
41%
-46
- C3 -
-
3RJC
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
63.95
41%
-50
- C3 -
-
3QXP
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
268
Blastp_CBE
63.94
41%
-47
- C3 -
-
3R8P
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Blastp_CBE
63.93
41%
-59
- C3 -
-
4FKQ
2
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
63.92
41%
-49
- C3 -
-
3EID
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
63.91
41%
-46
- C3 -
-
3RPV
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
63.90
41%
-47
- C3 -
-
2WPA
1
CDK2_HUMAN
C:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
63.89
41%
-44
- C3 -
-
3EOC
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
63.88
41%
-49
- C3 -
-
3R8Z
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
--------
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
63.87
41%
-47
- C3 -
-
2C6M
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
63.86
41%
-51
- C3 -
-
1H0V
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Blastp_CBE
63.87
41%
-49
- C3 -
-
5ANJ
1
CDK2_HUMAN
A:
[3-287]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
---------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
63.84
41%
-57
- C3 -
-
3RPR
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
Blastp_CBE
63.86
41%
-43
- C3 -
-
2XNB
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
--
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
63.81
41%
-45
- C3 -
-
3PXQ
4
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
63.83
41%
-49
- C3 -
-
2C5Y
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
63.84
41%
-51
- C3 -
-
3TI1
8
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
63.83
41%
-54
- C3 -
-
4FKO
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
207
Blastp_CBE
63.81
41%
-52
- C3 -
-
1E1X
2
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
Blastp_CBE
63.79
41%
-42
- C3 -
-
3EJ1
1
CDK2_HUMAN
C:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
63.71
41%
-40
- C3 -
-
2UUE
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
63.69
41%
-46
- C3 -
-
3QQL
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
63.68
41%
-55
- C3 -
-
4FKL
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
63.65
41%
-51
- C3 -
-
4LYN
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
63.62
41%
-48
- C3 -
-
3R9H
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
63.55
41%
-50
- C3 -
-
2WXV
1
CDK2_HUMAN
C:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
63.58
41%
-51
- C3 -
-
3QL8
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
63.52
41%
-48
- C3 -
-
6Q4I
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
L
---
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
63.57
41%
-79
- C3 -
-
2R3K
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
----------
D
L
K
K
---
F
---------
M
-
D
ASALT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
63.55
41%
-47
- C3 -
-
2I40
1
CDK2_HUMAN
C:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
63.52
41%
-58
- C3 -
-
1KE7
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
63.51
41%
-39
- C3 -
-
2C5V
1
CDK2_HUMAN
C:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
63.50
41%
-53
- C3 -
-
6Q4J
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
63.49
41%
-49
- C3 -
-
6Q4K
3
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
63.44
41%
-49
- C3 -
-
2WPA
1
CDK2_HUMAN
A:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
63.42
41%
-48
- C3 -
-
2C4G
1
CDK2_HUMAN
C:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
180
Blastp_CBE
63.44
41%
-56
- C3 -
-
1PXK
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
63.42
41%
-53
- C3 -
-
1PXM
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
63.43
41%
-49
- C3 -
-
2C69
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
63.42
41%
-49
- C3 -
-
3NS9
1
CDK2_HUMAN
A:
[3-287]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
280
Blastp_CBE
63.37
41%
-52
- C3 -
-
3R28
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
63.35
41%
-46
- C3 -
-
3QTW
6
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
63.37
41%
-46
- C3 -
-
3RM6
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
-
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
63.35
41%
-45
- C3 -
-
3QWK
5
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
63.34
41%
-46
- C3 -
-
3RK9
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
63.32
41%
-52
- C3 -
-
2VTM
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
63.31
41%
-46
- C3 -
-
2CLX
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
63.29
41%
-51
- C3 -
-
2R3F
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
63.29
41%
-49
- C3 -
-
3TIY
12
CDK2_HUMAN
A:
[2-287]
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
63.28
41%
-79
- C3 -
-
2R3L
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
----------
D
L
K
K
---
F
---------
M
-
D
ASALT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
63.26
41%
-56
- C3 -
-
1B39
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
63.25
41%
-61
- C3 -
-
1KE8
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
63.24
41%
-48
- C3 -
-
3RNI
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Blastp_CBE
63.23
41%
-52
- C3 -
-
3IGG
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
63.22
41%
-46
- C3 -
-
1FIN
1
CDK2_HUMAN
C:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Blastp_CBE
63.15
41%
-51
- C3 -
-
4FKU
3
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
63.11
41%
-53
- C3 -
-
3RKB
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
63.11
41%
-39
- C3 -
-
2C5X
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
189
Blastp_CBE
63.08
41%
-58
- C3 -
-
1KE6
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
63.07
41%
-42
- C3 -
-
2WEV
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
343
Blastp_CBE
63.01
41%
-41
- C3 -
-
5OO3
1
CDK2_HUMAN
A:
[7-292]
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
C
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
63.03
41%
-47
- C3 -
-
3RK5
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
63.05
41%
-57
- C3 -
-
1CKP
2
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
63.04
41%
-43
- C3 -
-
3QRT
3
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
169
Blastp_CBE
63.03
41%
-52
- C3 -
-
1W0X
1
CDK2_HUMAN
C:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
63.01
41%
-44
- C3 -
-
6Q4A
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
-
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
63.00
41%
-57
- C3 -
-
1KE5
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
62.96
41%
-45
- C3 -
-
3RK7
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
228
Blastp_CBE
62.96
41%
-46
- C3 -
-
6Q4B
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
62.98
41%
-58
- C3 -
-
1DI8
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
62.96
41%
-51
- C3 -
-
2I40
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
203
Blastp_CBE
62.93
41%
-60
- C3 -
-
1FVT
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
183
Blastp_CBE
62.94
41%
-51
- C3 -
-
1PF8
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
62.93
41%
-74
- C3 -
-
2R3J
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
----------
D
L
K
K
---
F
---------
M
-
D
ASALT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
62.92
41%
-51
- C3 -
-
2C6L
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
62.90
41%
-58
- C3 -
-
3RAH
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
62.88
41%
-57
- C3 -
-
2R64
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
62.87
41%
-59
- C3 -
-
6Q3B
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
197
Blastp_CBE
62.86
41%
-46
- C3 -
-
1H07
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
----
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Blastp_CBE
62.85
41%
-48
- C3 -
-
2VTR
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
62.82
41%
-48
- C3 -
-
2BPM
1
CDK2_HUMAN
C:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
322
Blastp_CBE
62.78
41%
-51
- C3 -
-
2WIP
1
CDK2_HUMAN
C:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
274
Blastp_CBE
62.77
41%
-57
- C3 -
-
3R7U
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
62.74
41%
-55
- C3 -
-
2R3R
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
62.73
41%
-52
- C3 -
-
3QWJ
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
62.67
41%
-38
- C3 -
-
4EZ7
7
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
62.66
41%
-42
- C3 -
-
3QTU
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
208
Blastp_CBE
62.65
41%
-50
- C3 -
-
1E1V
2
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
62.64
41%
-78
- C3 -
-
2R3M
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
----------
D
L
K
K
---
F
---------
M
-
D
ASALT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
62.60
41%
-46
- C3 -
-
3EOC
1
CDK2_HUMAN
C:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
62.58
41%
-46
- C3 -
-
1B38
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
62.57
41%
-54
- C3 -
-
3R9N
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
299
Blastp_CBE
62.55
41%
-57
- C3 -
-
3QTS
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
168
Blastp_CBE
62.52
41%
-53
- C3 -
-
1WCC
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
62.53
41%
-58
- C3 -
-
2W06
2
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
62.52
41%
-45
- C3 -
-
3LFS
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
Blastp_CBE
62.50
41%
-43
- C3 -
-
3EJ1
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
62.44
41%
-48
- C3 -
-
2C5X
1
CDK2_HUMAN
C:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
62.43
41%
-45
- C3 -
-
2VTL
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
Blastp_CBE
62.43
41%
-50
- C3 -
-
2W1H
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
62.42
41%
-49
- C3 -
-
2R3G
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
488
Blastp_CBE
62.38
40%
-43
- C3 -
-
6GU3
1
CDK1_HUMAN
A:
[6-292]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
----------
M
------
Q
D
----
S
R
L
Y
L
I
F
E
F
L
S
M
---
D
L
---
K
K
Y
L
D
S
---
I
---------
P
-
P
-----
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
----
T
-------------
P
N
N
E
V
W
-------
P
E
----
V
E
------
S
L
Q
D
Y
-
K
N
T
---
F
P
K
WKPGSLASHVKN
L
D
E
N
----
G
--------
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
332
Blastp_CBE
62.37
41%
-47
- C3 -
-
1VYW
1
CDK2_HUMAN
C:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
62.36
41%
-47
- C3 -
-
3LE6
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
------
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
62.36
41%
-60
- C3 -
-
3WBL
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
489
Blastp_CBE
62.33
40%
-51
- C3 -
-
6GU2
1
CDK1_HUMAN
A:
[6-292]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
----------
M
------
Q
D
----
S
R
L
Y
L
I
F
E
F
L
S
M
---
D
L
---
K
K
Y
L
D
S
---
I
---------
P
-
P
-----
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
---
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
----
T
-------------
P
N
N
E
V
W
-------
P
E
----
V
E
------
S
L
Q
D
Y
-
K
N
T
---
F
P
K
WKPGSLASHVKN
L
D
E
N
----
G
--------
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
487
Blastp_CBE
62.30
40%
-41
- C3 -
-
6GU4
1
CDK1_HUMAN
A:
[6-292]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
----------
M
------
Q
D
----
S
R
L
Y
L
I
F
E
F
L
S
M
---
D
L
---
K
K
Y
L
D
S
---
I
---------
P
-
P
-----
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
----
T
-------------
P
N
N
E
V
W
-------
P
E
----
V
E
------
S
L
Q
D
Y
-
K
N
T
---
F
P
K
WKPGSLASHVKN
L
D
E
N
----
G
--------
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
323
Blastp_CBE
62.28
41%
-48
- C3 -
-
2WIP
1
CDK2_HUMAN
A:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
62.27
41%
-49
- C3 -
-
2R3H
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Blastp_CBE
62.27
41%
-53
- C3 -
-
2VTO
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
62.23
41%
-47
- C3 -
-
2A4L
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
341
Blastp_CBE
62.22
41%
-49
- C3 -
-
5MHQ
1
?
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
I
R
L
----------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
62.18
41%
-52
- C3 -
-
2VTS
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
179
Blastp_CBE
62.15
41%
-52
- C3 -
-
1PXL
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
62.13
41%
-55
- C3 -
-
3ULI
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-----------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
62.12
41%
-77
- C3 -
-
4NJ3
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
----------
D
L
K
K
---
F
---------
M
-
D
ASALT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
240
Blastp_CBE
62.07
41%
-52
- C3 -
-
3S0O
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
--
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
342
Blastp_CBE
62.06
41%
-41
- C3 -
-
5OSM
1
CDK2_HUMAN
A:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
C
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
62.01
41%
-58
- C3 -
-
4FKR
2
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
62.00
41%
-44
- C3 -
-
6Q4D
6
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
61.98
41%
-49
- C3 -
-
1Y91
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
494
Blastp_CBE
61.89
40%
-43
- C3 -
-
4Y72
1
CDK1_HUMAN
A:
[6-292]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
----------
M
------
Q
D
----
S
R
L
Y
L
I
F
E
F
L
S
M
---
D
L
---
K
K
Y
L
D
S
---
I
---------
P
-
P
-----
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
----
T
-------------
P
N
N
E
V
W
-------
P
E
----
V
E
------
S
L
Q
D
Y
-
K
N
T
---
F
P
K
WKPGSLASHVKN
L
D
E
N
----
G
--------
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
61.96
41%
-57
- C3 -
-
4EK8
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
61.96
41%
-48
- C3 -
-
5FP6
2
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
--------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
61.93
41%
-57
- C3 -
-
6GUK
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
61.92
41%
-41
- C3 -
-
3SQQ
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
------
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
61.91
41%
-56
- C3 -
-
3SW4
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
61.90
41%
-42
- C3 -
-
3LFQ
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
61.89
40%
-43
- C3 -
-
5HQ0
1
CDK1_HUMAN
A:
[6-292]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
----------
M
------
Q
D
----
S
R
L
Y
L
I
F
E
F
L
S
M
---
D
L
---
K
K
Y
L
D
S
---
I
---------
P
-
P
-----
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
----
T
-------------
P
N
N
E
V
W
-------
P
E
----
V
E
------
S
L
Q
D
Y
-
K
N
T
---
F
P
K
WKPGSLASHVKN
L
D
E
N
----
G
--------
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
61.85
40%
-39
- C3 -
-
6GU6
1
CDK1_HUMAN
A:
[6-292]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
----------
M
------
Q
D
----
S
R
L
Y
L
I
F
E
F
L
S
M
---
D
L
---
K
K
Y
L
D
S
---
I
---------
P
-
P
-----
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
-------
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
----
T
-------------
P
N
N
E
V
W
-------
P
E
----
V
E
------
S
L
Q
D
Y
-
K
N
T
---
F
P
K
WKPGSLASHVKN
L
D
E
N
----
G
--------
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
61.84
41%
-47
- C3 -
-
3F5X
2
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
-
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
231
Blastp_CBE
61.83
41%
-58
- C3 -
-
6Q48
2
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
61.81
41%
-58
- C3 -
-
5K4J
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
552
HHSearch
61.79
35%
-35
- C3 -
-
5BYZ
7
MK07_HUMAN
A:
[6-303]
-
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
-
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
---
H
D
N
I
I
A
I
K
D
I
L
----------
R
PTVPYG
E
F
----
K
S
V
Y
V
V
L
D
L
M
E
S
----
D
---
L
H
Q
I
I
H
---
S
---------
S
-
Q
-----
P
--
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
-
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQY
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
-
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
----
T
P
----
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
-
L
P
P
-----
R
------
Q
P
V
P
W
-
E
T
V
---
Y
P
G
------------
A
D
R
Q
----
A
--------
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
61.76
41%
-50
- C3 -
-
3RZB
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
61.76
41%
-55
- C3 -
-
6Q4E
3
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
61.77
39%
-110
- C3 -
-
3O0G
1
CDK5_HUMAN
B:
[6-286]
-----
K
L
E
K
I
-----
G
T
V
F
K
A
-------
E
I
V
A
L
K
R
V
R
--------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
----------
H
------
S
D
----
K
K
L
T
L
V
F
E
F
C
D
Q
---
D
L
---
K
K
Y
F
D
S
---
C
---------
N
-
G
-----
D
--
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
----
T
P
----
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
Y
----
P
M
----
Y
P
------
A
T
T
S
L
-
V
N
V
---
V
P
K
------------
L
N
A
T
----
G
--------
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
220
Blastp_CBE
61.76
42%
-54
- C3 -
-
1GII
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
H
V
H
Q
DLK
T
F
---
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
61.68
41%
-58
- C3 -
-
4FKT
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
61.68
41%
-57
- C3 -
-
5IEV
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
61.65
41%
-56
- C3 -
-
4D1X
1
CDK2_HUMAN
A:
[3-287]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
61.60
41%
-51
- C3 -
-
3R9O
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
61.57
41%
-54
- C3 -
-
3EZV
1
CDK2_HUMAN
A:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
61.56
41%
-58
- C3 -
-
4FKP
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
61.52
41%
-56
- C3 -
-
2VV9
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
61.52
41%
-59
- C3 -
-
5IEY
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-----------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
61.48
41%
-55
- C3 -
-
2VTI
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
Blastp_CBE
61.44
41%
-59
- C3 -
-
2VTP
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
61.43
41%
-48
- C3 -
-
2B52
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
300
Blastp_CBE
61.29
41%
-53
- C3 -
-
3QTR
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
339
Blastp_CBE
61.23
41%
-49
* C3 *
-
4EOI
1
CDK2_HUMAN
C:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
---
K
D
F
M
D
A
---
S
---------
A
L
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
Blastp_CBE
61.21
41%
-49
- C3 -
-
3FZ1
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
61.11
41%
-50
- C3 -
-
1GIH
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
61.08
41%
-57
- C3 -
-
5AND
1
CDK2_HUMAN
A:
[2-287]
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
61.06
41%
-54
- C3 -
-
4BZD
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
351
Blastp_CBE
60.98
41%
-54
- C3 -
-
4EOK
1
CDK2_HUMAN
C:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
---
D
L
---
K
D
F
M
D
A
---
S
---------
A
L
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
60.95
41%
-55
- C3 -
-
4ACM
3
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
------
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
60.93
41%
-60
- C3 -
-
2VTH
2
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Blastp_CBE
60.84
41%
-56
- C3 -
-
5ANI
1
CDK2_HUMAN
A:
[2-287]
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
60.81
41%
-57
- C3 -
-
3SW7
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
543
HHSearch
60.80
35%
-37
- C3 -
-
4ZSG
6
MK07_HUMAN
A:
[7-303]
-
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
-
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
---
H
D
N
I
I
A
I
K
D
I
L
----------
R
PTVPYG
E
F
----
K
S
V
Y
V
V
L
D
L
M
E
S
----
D
---
L
H
Q
I
I
H
---
S
---------
S
-
Q
-----
P
--
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
-
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQY
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
-
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
----
T
P
----
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
-
L
P
P
-----
R
------
Q
P
V
P
W
-
E
T
V
---
Y
P
G
------------
A
D
R
Q
----
A
--------
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
493
Blastp_CBE
60.67
40%
-41
- C3 -
-
4YC3
1
CDK1_HUMAN
A:
[6-292]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
L
----------
M
------
Q
D
----
S
R
L
Y
L
I
F
E
F
L
S
M
---
D
L
---
K
K
Y
L
D
S
---
I
---------
P
-
P
-----
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
-
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
---
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
----
T
-------------
P
N
N
E
V
W
-------
P
E
----
V
E
------
S
L
Q
D
Y
-
K
N
T
---
F
P
K
WKPGSLASHVKN
L
D
E
N
----
G
--------
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
219
Blastp_CBE
60.70
42%
-50
- C3 -
-
1GIJ
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
H
V
H
Q
DLK
T
F
---
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
60.70
41%
-47
- C3 -
-
5A14
2
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
--
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
60.67
41%
-50
- C3 -
-
1H08
2
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
60.65
41%
-63
- C3 -
-
2IW9
1
CDK2_HUMAN
A:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
DLK
T
F
---
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
60.64
41%
-50
- C3 -
-
5IEX
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
60.63
41%
-55
- C3 -
-
2VTA
3
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
60.62
41%
-61
- C3 -
-
1OI9
1
CDK2_HUMAN
C:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Blastp_CBE
60.59
41%
-49
- C3 -
-
3IG7
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
60.58
41%
-63
- C3 -
-
1E9H
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
60.44
41%
-54
- C3 -
-
4EON
1
CDK2_HUMAN
C:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
60.47
41%
-56
- C3 -
-
4FKS
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
60.45
41%
-59
- C3 -
-
5L2W
2
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
159
Blastp_CBE
60.44
41%
-48
- C3 -
-
2B55
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
60.43
41%
-46
- C3 -
-
5JQ5
1
CDK2_HUMAN
A:
[3-287]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
60.42
41%
-51
- C3 -
-
1AQ1
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
60.40
41%
-55
- C3 -
-
2UZN
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
60.38
41%
-57
- C3 -
-
2DUV
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
60.33
41%
-54
- C3 -
-
3S2P
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
172
Blastp_CBE
60.32
41%
-59
- C3 -
-
1URW
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
156
Blastp_CBE
60.30
41%
-58
- C3 -
-
2BTR
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
60.23
41%
-55
- C3 -
-
3S1H
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
60.23
41%
-58
- C3 -
-
4FKW
2
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
60.15
41%
-59
- C3 -
-
6GUF
1
CDK2_HUMAN
C:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
60.21
41%
-57
- C3 -
-
5JQ8
1
CDK2_HUMAN
A:
[3-287]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
60.20
41%
-61
- C3 -
-
5CYI
1
CDK2_HUMAN
C:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
349
Blastp_CBE
60.19
41%
-48
- C3 -
-
4EOL
1
CDK2_HUMAN
C:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
---
D
L
---
K
D
F
M
D
A
---
S
---------
A
L
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
157
Blastp_CBE
60.16
41%
-51
- C3 -
-
2BHH
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
60.15
41%
-55
- C3 -
-
4EON
1
CDK2_HUMAN
A:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
60.14
41%
-56
- C3 -
-
3RPY
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
60.13
41%
-57
- C3 -
-
4EOK
1
CDK2_HUMAN
A:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
---
D
L
---
K
D
F
M
D
A
---
S
---------
A
L
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
60.08
41%
-56
- C3 -
-
1H00
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
60.03
41%
-65
- C3 -
-
3DDP
1
CDK2_HUMAN
C:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
269
Blastp_CBE
60.02
41%
-50
- C3 -
-
3R8M
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
59.99
41%
-61
- C3 -
-
2IW6
1
CDK2_HUMAN
A:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
DLK
T
F
---
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
59.98
41%
-55
- C3 -
-
3RAK
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
59.97
41%
-59
- C3 -
-
5CYI
1
CDK2_HUMAN
A:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
Blastp_CBE
59.96
41%
-52
- C3 -
-
2VU3
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
----
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
59.90
41%
-59
- C3 -
-
1H1R
1
CDK2_HUMAN
C:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
340
Blastp_CBE
59.85
41%
-50
- C3 -
-
4EOI
2
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
---
K
D
F
M
D
A
---
S
---------
A
L
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
402
Blastp_CBE
59.82
41%
-61
- C3 -
-
2CCI
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
354
Blastp_CBE
59.79
41%
-56
- C3 -
-
4EOJ
1
CDK2_HUMAN
A:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
---
D
L
---
K
D
F
M
D
A
---
S
---------
A
L
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
59.70
41%
-54
- C3 -
-
3RAL
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
59.59
41%
-55
- C3 -
-
4EOP
1
CDK2_HUMAN
C:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
59.64
41%
-51
- C3 -
-
4FKV
2
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
59.56
41%
-56
- C3 -
-
1OIY
1
CDK2_HUMAN
C:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
59.57
41%
-59
- C3 -
-
2UZL
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
59.59
41%
-51
- C3 -
-
3RMF
1
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
59.58
41%
-56
- C3 -
-
5NEV
1
?
C:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
59.57
41%
-60
- C3 -
-
5ANK
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
--------------
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
376
Blastp_CBE
59.56
41%
-57
- C3 -
-
2UZE
1
CDK2_HUMAN
C:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
59.47
39%
-105
- C3 -
-
1UNG
1
CDK5_HUMAN
B:
[2-286]
-
Q
K
Y
E
K
L
E
K
-------
T
V
F
K
A
--------
I
V
A
L
K
R
V
R
L
D
----
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
L
----------
H
------
S
D
----
K
K
L
T
L
V
F
E
F
C
D
Q
---
D
L
---
K
K
Y
F
D
S
---
C
---------
N
-
G
-----
D
--
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
----
T
P
----
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
P
Y
----
P
M
----
Y
P
------
A
T
T
S
L
-
V
N
V
---
V
P
K
------------
L
N
A
T
----
G
--------
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
59.51
41%
-61
- C3 -
-
3DDQ
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
209
Blastp_CBE
59.50
41%
-51
- C3 -
-
1DM2
5
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
379
Blastp_CBE
59.47
41%
-56
- C3 -
-
2UZD
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
535
Blastp_CBE
59.42
37%
-42
- C3 -
-
5L2T
1
CDK6_HUMAN
A:
[11-301]
-
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
---------
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
-----------------------
T
K
L
T
L
V
F
E
H
V
D
Q
---
D
L
---
T
T
Y
L
D
K
---
V
---------
P
-
E
P----
G
--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
-
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
----------
L
P
G
E
E
D
W
P
R
D
------
V
-
A
-
L
P
R
QAFH
S
K
------
S
A
Q
P
I
-
E
K
F
---
V
T
D
------------
I
D
E
L
----
G
--------
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
473
Blastp_CBE
59.41
41%
-59
- C3 -
-
1H1P
1
CDK2_HUMAN
A:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
59.38
35%
-86
- C3 -
-
3GC0
1
?
A:
[33-327]
I
D
R
Y
R
R
I
T
K
L
G
E
G
T
Y
G
E
V
Y
K
A
I
D
-
T
V
T
N
E
T
V
A
I
K
R
I
R
L
E
H
-------
T
A
I
R
E
V
S
L
L
K
E
L
Q
---
H
R
N
I
I
E
L
K
S
V
I
----------
H
------
H
N
----
H
R
L
H
L
I
F
E
Y
A
E
N
---
D
L
---
K
K
Y
M
D
K
---
N
---------
P
-
D
--------
V
S
M
R
V
I
K
S
F
L
Y
Q
L
I
N
G
V
N
F
C
H
S
R
R
C
L
H
R
D
L
K
P
Q
N
L
L
L
S
V
E
-
T
P
V
L
K
I
G
D
F
G
L
A
R
A
F
-------------
E
I
I
T
L
W
Y
R
P
P
E
I
L
L
G
S
R
H
Y
S
T
S
V
D
I
W
S
I
A
C
I
W
A
E
M
L
-
M
K
T
P
L
F
P
G
D
S
E
I
D
Q
L
F
K
I
F
E
V
L
G
-----------------
L
P
D
D
T
T
W
P
G
V
-
T
A
L
P
D
----
W
K
------
Q
S
F
P
--
K
F
R
---
G
K
T
------------
L
K
R
V
----
L
GALLDDEG
L
D
L
L
T
A
M
L
E
M
D
P
V
K
R
I
S
A
K
N
A
L
E
H
P
Y
F
S
H
N
D
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
398
Blastp_CBE
59.37
41%
-56
- C3 -
-
3DDP
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
59.35
41%
-60
- C3 -
-
6GUC
1
CDK2_HUMAN
C:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
59.26
41%
-57
- C3 -
-
3QHR
6
CDK2_HUMAN
A:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
373
Blastp_CBE
59.33
41%
-55
- C3 -
-
4II5
2
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
59.26
41%
-56
- C3 -
-
2IW8
1
CDK2_HUMAN
A:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
H
V
D
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
59.29
41%
-50
- C3 -
-
4BGH
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
59.26
41%
-42
- C3 -
-
6GUH
3
CDK2_HUMAN
A:
[9-295]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
--------
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
59.22
41%
-57
- C3 -
-
4CFW
1
CDK2_HUMAN
A:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
59.21
41%
-64
- C3 -
-
3BHU
1
CDK2_HUMAN
A:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
59.18
41%
-63
- C3 -
-
1JST
1
CDK2_HUMAN
C:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
59.17
41%
-57
- C3 -
-
4CFN
1
CDK2_HUMAN
C:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
372
Blastp_CBE
59.08
41%
-55
- C3 -
-
4II5
3
CDK2_HUMAN
C:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
59.12
41%
-54
- C3 -
-
6INL
1
?
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
59.09
41%
-57
- C3 -
-
3QHW
3
CDK2_HUMAN
C:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
59.08
41%
-56
- C3 -
-
3EZR
2
CDK2_HUMAN
A:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
Blastp_CBE
59.06
41%
-43
- C3 -
-
2VTN
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
--------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
59.04
41%
-58
- C3 -
-
3DOG
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
358
Blastp_CBE
58.98
41%
-62
- C3 -
-
4EOM
1
CDK2_HUMAN
A:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
400
Blastp_CBE
59.00
41%
-59
- C3 -
-
2G9X
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
58.98
41%
-50
- C3 -
-
2FVD
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
--
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
58.97
41%
-57
- C3 -
-
4EOS
1
CDK2_HUMAN
C:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
408
Blastp_CBE
58.86
41%
-61
- C3 -
-
1P5E
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
58.92
41%
-57
- C3 -
-
1H1P
1
CDK2_HUMAN
C:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
356
Blastp_CBE
58.88
41%
-52
- C3 -
-
4EOP
1
CDK2_HUMAN
A:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
58.86
41%
-55
- C3 -
-
1PKD
1
CDK2_HUMAN
C:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
58.78
41%
-59
- C3 -
-
1H1S
1
CDK2_HUMAN
C:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
58.83
41%
-53
- C3 -
-
2UZE
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
58.81
41%
-61
- C3 -
-
2IW6
1
CDK2_HUMAN
C:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
DLK
T
F
---
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
58.79
41%
-54
- C3 -
-
3QHW
2
CDK2_HUMAN
A:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
58.78
41%
-60
- C3 -
-
2W17
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
-
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
-----
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
434
Blastp_CBE
58.74
41%
-57
- C3 -
-
4BCM
1
CDK2_HUMAN
C:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
58.71
41%
-59
- C3 -
-
5LMK
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
58.69
41%
-51
- C3 -
-
2W05
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
484
Blastp_CBE
58.67
41%
-61
- C3 -
-
6GUE
1
CDK2_HUMAN
A:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
N
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
467
Blastp_CBE
58.56
41%
-57
- C3 -
-
1H1S
1
CDK2_HUMAN
A:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
58.63
41%
-61
- C3 -
-
4EOO
1
CDK2_HUMAN
A:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
374
Blastp_CBE
58.61
41%
-52
- C3 -
-
2UZL
1
CDK2_HUMAN
C:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
58.59
41%
-62
- C3 -
-
6GUF
1
CDK2_HUMAN
A:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
58.58
41%
-54
- C3 -
-
2VTT
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
58.56
41%
-55
- C3 -
-
4BCO
1
CDK2_HUMAN
A:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
450
Blastp_CBE
58.53
41%
-58
- C3 -
-
1OIU
1
CDK2_HUMAN
A:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
58.40
41%
-56
- C3 -
-
4EOR
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
359
Blastp_CBE
58.41
41%
-56
- C3 -
-
4EOO
1
CDK2_HUMAN
C:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
58.38
41%
-64
- C3 -
-
6GUC
1
CDK2_HUMAN
A:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
58.43
41%
-55
- C3 -
-
4I3Z
3
CDK2_HUMAN
C:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
370
Blastp_CBE
58.42
41%
-57
- C3 -
-
1E9H
1
CDK2_HUMAN
C:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
58.41
41%
-56
- C3 -
-
5OO1
1
CDK2_HUMAN
A:
[9-292]
---
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
C
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
58.40
41%
-56
- C3 -
-
2VTQ
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
58.39
41%
-54
- C3 -
-
1GY3
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
58.38
41%
-64
- C3 -
-
3MY5
3
CDK2_HUMAN
A:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
58.37
41%
-60
- C3 -
-
6GVA
3
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
--
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
58.35
41%
-55
- C3 -
-
1V1K
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
58.27
41%
-61
- C3 -
-
1H1Q
1
CDK2_HUMAN
A:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
403
Blastp_CBE
58.27
41%
-54
- C3 -
-
2CCH
1
CDK2_HUMAN
C:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
58.17
41%
-53
- C3 -
-
4I3Z
4
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
58.29
41%
-65
- C3 -
-
6GUB
1
CDK2_HUMAN
A:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
58.27
41%
-58
- C3 -
-
2UZD
1
CDK2_HUMAN
C:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
58.25
41%
-60
- C3 -
-
6GUB
1
?
C:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFP-----
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
461
Blastp_CBE
58.17
41%
-55
- C3 -
-
4CFW
1
CDK2_HUMAN
C:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
58.23
41%
-57
- C3 -
-
1G5S
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
58.22
41%
-52
- C3 -
-
2C6T
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
58.18
41%
-55
- C3 -
-
4EOS
1
CDK2_HUMAN
A:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
407
Blastp_CBE
58.17
41%
-63
- C3 -
-
1P5E
1
CDK2_HUMAN
C:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
58.16
41%
-56
- C3 -
-
4BCP
1
CDK2_HUMAN
A:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
405
Blastp_CBE
58.13
41%
-56
- C3 -
-
1QMZ
1
CDK2_HUMAN
C:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
429
Blastp_CBE
58.12
41%
-62
- C3 -
-
3BHT
1
CDK2_HUMAN
A:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
58.11
41%
-59
- C3 -
-
1OGU
1
CDK2_HUMAN
A:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
58.10
41%
-56
- C3 -
-
4CFX
1
CDK2_HUMAN
C:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
420
Blastp_CBE
58.05
41%
-54
- C3 -
-
3TNW
1
CDK2_HUMAN
C:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
425
Blastp_CBE
58.03
41%
-61
- C3 -
-
3BHV
2
CDK2_HUMAN
A:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
421
Blastp_CBE
57.93
41%
-63
- C3 -
-
3TNW
1
CDK2_HUMAN
A:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
369
Blastp_CBE
57.99
41%
-58
- C3 -
-
1PKD
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
57.88
41%
-57
- C3 -
-
2UZB
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
401
Blastp_CBE
57.93
41%
-61
- C3 -
-
2CCI
1
CDK2_HUMAN
C:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
460
Blastp_CBE
57.85
41%
-59
- C3 -
-
4CFX
1
CDK2_HUMAN
A:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
456
Blastp_CBE
57.92
41%
-57
- C3 -
-
5NEV
1
CDK2_HUMAN
A:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
435
Blastp_CBE
57.91
41%
-60
- C3 -
-
4BCM
1
CDK2_HUMAN
A:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
350
Blastp_CBE
57.88
41%
-51
- C3 -
-
4EOL
1
CDK2_HUMAN
A:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
---
D
L
---
K
D
F
M
D
A
---
S
----------L
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
57.85
41%
-56
- C3 -
-
4BCN
1
CDK2_HUMAN
A:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
57.76
41%
-51
- C3 -
-
4CFM
1
CDK2_HUMAN
A:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
482
Blastp_CBE
57.75
41%
-55
- C3 -
-
3QHR
2
CDK2_HUMAN
C:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
57.82
41%
-58
- C3 -
-
4BCN
1
CDK2_HUMAN
C:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
57.81
41%
-55
- C3 -
-
1P2A
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
57.76
41%
-55
- C3 -
-
2C6T
1
CDK2_HUMAN
C:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
57.75
41%
-55
- C3 -
-
1OI9
1
CDK2_HUMAN
A:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
57.74
41%
-60
- C3 -
-
4CFN
1
CDK2_HUMAN
A:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
57.71
41%
-62
- C3 -
-
2UZB
1
CDK2_HUMAN
C:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
57.60
41%
-57
- C3 -
-
1GY3
2
CDK2_HUMAN
C:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
57.65
41%
-55
- C3 -
-
5FP5
3
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
-------
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
--------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
57.64
41%
-50
- C3 -
-
1R78
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
--------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
404
Blastp_CBE
57.54
41%
-57
- C3 -
-
2CCH
3
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
57.60
41%
-54
- C3 -
-
1JST
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
479
Blastp_CBE
57.57
41%
-60
- C3 -
-
4CFU
1
CDK2_HUMAN
A:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
470
Blastp_CBE
57.56
41%
-61
- C3 -
-
1H1Q
1
CDK2_HUMAN
C:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
57.55
41%
-55
- C3 -
-
1QMZ
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
57.54
41%
-54
- C3 -
-
1OIT
1
CDK2_HUMAN
A:
[3-287]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
-
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
S
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
57.53
41%
-58
- C3 -
-
4CFV
1
CDK2_HUMAN
A:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
57.45
41%
-55
- C3 -
-
1H1R
1
CDK2_HUMAN
A:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
57.27
41%
-59
- C3 -
-
1OIY
1
CDK2_HUMAN
A:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
57.25
41%
-61
- C3 -
-
4BCK
2
CDK2_HUMAN
A:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
509
Blastp_CBE
57.23
35%
-39
- C3 -
-
4KRC
1
PHO85_YEAST
A:
[6-297]
--
Q
F
K
Q
L
E
K
L
G
N
G
T
Y
A
T
V
Y
K
G
L
N
-
K
T
T
G
V
Y
V
A
L
K
E
-
V
K
L
D
S
E
E
G
T
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
---
H
E
N
I
V
R
L
Y
D
V
I
----------
H
------
T
E
----
N
K
L
T
L
V
F
E
F
M
D
----------
N
D
L
K
K
---
Y
MDSRT----
P
-
R
-----
G
--
L
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
K
-
R
G
Q
L
K
L
G
D
F
G
L
A
R
A
F
G
I
P
V
N
----
T
F
S
S
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
-
T
G
K
P
L
F
P
G
T
N
D
E
E
Q
L
K
L
I
F
D
I
M
G
TPNE
S
L
----
W
P
S
V
T
K
L
P
K
Y
N
----------
P
N
----
I
Q
------
Q
R
P
P
R
-
D
L
R
QVL
Q
P
H
------------
T
K
E
P
LDGN
L
--------
M
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
418
Blastp_CBE
57.21
41%
-63
- C3 -
-
4BCK
1
CDK2_HUMAN
C:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
57.20
41%
-61
- C3 -
-
4EOQ
1
CDK2_HUMAN
A:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
57.19
41%
-63
- C3 -
-
4EOM
1
CDK2_HUMAN
C:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
-----------------------------
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Blastp_CBE
57.18
41%
-60
- C3 -
-
5ANG
1
CDK2_HUMAN
A:
[2-287]
-
E
N
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
-------
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
399
Blastp_CBE
57.15
41%
-62
- C3 -
-
2G9X
1
CDK2_HUMAN
C:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
-----------------------------
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
56.88
41%
-52
- C3 -
-
6GUE
1
CDK2_HUMAN
C:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
-----T
S
-
M
P
D
----
Y
K
PSFPK---
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
433
Blastp_CBE
56.79
41%
-61
- C3 -
-
4BCQ
1
CDK2_HUMAN
A:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
551
HHSearch
56.71
34%
-30
- C3 -
-
4NM3
5
GSK3B_HUMAN
A:
[55-342]
--
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
---
H
C
N
I
V
R
L
R
Y
F
F
----------
Y
------
S
S
KKDE
V
Y
L
N
L
V
L
D
Y
V
P
E
---
T
V
---
Y
R
V
A
R
H
YSR
A
---------
K
-
Q
-----
T
--
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
-
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
-
E
----
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
-
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
----
T
P
----
T
R
E
Q
I
R
--
E
M
N
P
N
Y
T
E
F
-
K
-
F
P
Q
----
I
K
------
A
H
P
W
T
-
K
V
F
---
R
P
R
------------
T
P
P
E
----
A
--------
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
56.67
41%
-58
- C3 -
-
1OIQ
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
-------
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
--------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
432
Blastp_CBE
56.48
41%
-56
- C3 -
-
4BCQ
1
CDK2_HUMAN
C:
[4-290]
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
353
Blastp_CBE
56.46
41%
-61
- C3 -
-
4EOJ
1
CDK2_HUMAN
C:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
---
D
L
---
K
D
F
M
D
A
---
S
---------
A
L
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
----------------------
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
56.38
41%
-66
- C3 -
-
3BHT
1
CDK2_HUMAN
C:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
--------------------------------
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
56.23
41%
-63
- C3 -
-
1OGU
1
CDK2_HUMAN
C:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
--------------------------------
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
56.29
41%
-44
- C3 -
-
1FQ1
1
CDK2_HUMAN
B:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
56.23
41%
-67
- C3 -
-
4EOQ
1
CDK2_HUMAN
C:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
-----------------------------
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
56.22
41%
-63
- C3 -
-
2IW8
1
CDK2_HUMAN
C:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
H
V
D
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-----------------------------------------------------
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
56.15
41%
-63
- C3 -
-
2IW9
1
CDK2_HUMAN
C:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
DLK
T
F
---
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
-------------------------------------
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
56.01
41%
-78
- C3 -
-
2R3N
1
CDK2_HUMAN
A:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
----------
D
L
K
K
---
F
---------
M
-
D
ASALT
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
478
Blastp_CBE
55.96
41%
-65
- C3 -
-
4CFU
1
CDK2_HUMAN
C:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
--------------------------------
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
55.73
41%
-64
- C3 -
-
3BHV
1
CDK2_HUMAN
C:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
--------------------------------
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
55.60
41%
-63
- C3 -
-
3BHU
1
CDK2_HUMAN
C:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
--------------------------------
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
55.60
41%
-54
- C3 -
-
1PYE
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
------
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
55.38
41%
-62
- C3 -
-
4EOR
1
CDK2_HUMAN
C:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
-----------------------------
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
55.29
41%
-65
- C3 -
-
3DOG
1
CDK2_HUMAN
C:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
---------------------------------------
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
55.25
41%
-62
- C3 -
-
4BCO
1
CDK2_HUMAN
C:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
---------------------------------
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
55.22
41%
-58
- C3 -
-
4CFM
1
CDK2_HUMAN
C:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
---------------------------------------
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
55.17
41%
-48
- C3 -
-
5D1J
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
--------------
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
523
Blastp_CBE
55.00
35%
-33
- C3 -
-
4NST
3
CDK12_HUMAN
A:
[12-309]
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
-
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
---
H
R
S
V
V
N
M
K
E
I
V
TDKQD------------------
G
A
F
Y
L
V
F
E
Y
M
D
H
---
D
L
---
M
G
L
L
E
S
---
G
---------
L
-
V
-----
H
--
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
-
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
----
R
P
Y
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
----
S
P
----
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
-
K
--
P
K
----
K
Q
------
Y
R
R
R
L
-
R
E
E
---
F
S
F
------------
I
P
S
A
----
A
--------
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
449
Blastp_CBE
54.86
41%
-64
- C3 -
-
1OIU
1
CDK2_HUMAN
C:
[5-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-----------------------------------------------------
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
54.83
35%
-25
- C3 -
-
2PMI
2
PHO85_YEAST
A:
[19-297]
---------------
A
T
V
Y
K
G
L
N
-
K
T
T
G
V
Y
V
A
L
K
E
-
V
K
L
D
S
E
E
G
T
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
---
H
E
N
I
V
R
L
Y
D
V
I
----------
H
------
T
E
----
N
K
L
T
L
V
F
E
F
M
D
----------
N
D
L
K
K
---
Y
MDSRTVGNT
P
-
R
-----
G
--
L
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
K
-
R
G
Q
L
K
L
G
D
F
G
L
A
R
A
F
G
I
P
V
N
----
T
F
S
S
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
-
T
G
K
P
L
F
P
G
T
N
D
E
E
Q
L
K
L
I
F
D
I
M
G
TPNE
S
L
----
W
P
S
V
T
K
L
P
K
Y
N
----------
P
N
----
I
Q
------
Q
R
P
P
R
-
D
L
R
QVL
Q
P
H
------------
T
K
E
P
LDGN
L
--------
M
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
520
Blastp_CBE
54.68
35%
-26
- C3 -
-
6CKX
1
C:
[12-309]
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
-
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
---
H
R
S
V
V
N
M
K
E
I
V
T----------------
D
K
----
G
A
F
Y
L
V
F
E
Y
M
D
H
---
D
L
---
M
G
L
L
E
S
---
G
---------
L
-
V
-----
H
--
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
-
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
----
R
P
Y
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
----
S
P
----
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
-
K
--
P
K
----
K
Q
------
Y
R
R
R
L
-
R
E
E
---
F
S
F
------------
I
P
S
A
----
A
--------
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
525
Blastp_CBE
54.65
34%
-14
- C3 -
-
5EFQ
2
CDK13_HUMAN
A:
[10-307]
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
R
D
-
K
D
T
G
E
M
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
T
---
H
Q
S
I
I
N
M
K
E
I
V
TDKE-------------------
G
A
F
Y
L
V
F
E
Y
M
D
H
---
D
L
---
M
G
L
L
E
S
---
G
---------
L
-
V
-----
H
--
F
N
E
N
H
I
K
S
F
M
R
Q
L
M
E
G
L
D
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
-
N
-
R
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
S
S
E
E
S
----
R
P
Y
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
Q
E
L
A
Q
L
E
L
I
S
R
I
C
G
----
S
P
----
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
-
K
--
P
K
----
K
Q
------
Y
R
R
K
L
-
R
E
E
---
F
V
F
------------
I
P
A
A
----
A
--------
L
D
L
F
D
Y
M
L
A
L
D
P
S
K
R
C
T
A
E
Q
A
L
Q
C
E
F
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
367
Blastp_CBE
54.60
41%
-65
- C3 -
-
5LMK
1
?
C:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-----------------------------------------------------
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
54.42
35%
-21
- C3 -
-
4CXA
1
CDK12_HUMAN
A:
[12-309]
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
-
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
---
H
R
S
V
V
N
M
K
E
I
V
TDKQLDFK--
K
------
D
K
----
G
A
F
Y
L
V
F
E
Y
M
D
H
---
D
L
---
M
G
L
L
E
S
---
G
---------
L
-
V
-----
H
--
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
-
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
-----
R
P
Y
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
----
S
P
----
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
-
K
--
P
K
----
K
Q
------
Y
R
R
R
L
-
R
E
E
---
F
S
F
------------
I
P
S
A
----
A
--------
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
524
Blastp_CBE
54.34
34%
-15
- C3 -
-
5EFQ
2
C:
[10-307]
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
R
D
-
K
D
T
G
E
M
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
T
---
H
Q
S
I
I
N
M
K
E
I
V
TDKE-------------------
G
A
F
Y
L
V
F
E
Y
M
D
H
---
D
L
---
M
G
L
L
E
S
---
G
---------
L
-
V
-----
H
--
F
N
E
N
H
I
K
S
F
M
R
Q
L
M
E
G
L
D
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
-
N
-
R
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
S
S
E
E
S
----
R
P
Y
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
Q
E
L
A
Q
L
E
L
I
S
R
I
C
G
----
S
P
----
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
-
K
--
P
K
----
K
Q
------
Y
R
R
K
L
-
R
E
E
---
F
V
F
------------
I
P
A
A
----
A
--------
L
D
L
F
D
Y
M
L
A
L
D
P
S
K
R
C
T
A
E
Q
A
L
Q
C
E
F
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
54.07
41%
-65
- C3 -
-
4BCP
1
CDK2_HUMAN
C:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
--------------------------------
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
53.96
41%
-68
- C3 -
-
3MY5
1
CDK2_HUMAN
C:
[3-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
----------------------------------------------------
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
53.89
41%
-66
- C3 -
-
4CFV
1
CDK2_HUMAN
C:
[6-292]
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
---------------------------------------
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
518
Blastp_CBE
53.77
35%
-14
- C3 -
-
5ACB
1
CDK12_HUMAN
C:
[12-309]
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
-
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
---
H
R
S
V
V
N
M
K
E
I
V
TDKQDALDFK
K
------
D
K
----
G
A
F
Y
L
V
F
E
Y
M
D
H
---
D
L
---
M
G
L
L
E
S
---
G
---------
L
-
V
-----
H
--
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
-
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
----
R
P
Y
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
----
S
P
----
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
-
K
--
P
K
----
K
Q
------
Y
R
R
R
L
-
R
E
E
---
F
S
F
------------
I
P
S
A
----
A
--------
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
521
Blastp_CBE
53.84
35%
-25
- C3 -
-
6CKX
1
CDK12_HUMAN
A:
[12-309]
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
-
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
---
H
R
S
V
V
N
M
K
E
I
V
T----------------
D
K
----
G
A
F
Y
L
V
F
E
Y
M
D
H
---
D
L
---
M
G
L
L
E
S
---
G
---------
L
-
V
-----
H
--
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
-
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
----
R
P
Y
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
----
S
P
----
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
-
K
--
P
K
----
K
Q
------
Y
R
R
R
L
-
R
E
E
---
F
S
F
------------
I
P
S
A
----
A
--------
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
395
Blastp_CBE
53.81
41%
-60
- C3 -
-
3DDQ
1
CDK2_HUMAN
C:
[2-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-----------------------------------------------------
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
516
Blastp_CBE
53.77
35%
-26
- C3 -
-
6B3E
1
CDK12_HUMAN
A:
[8-305]
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
-
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
---
H
R
S
V
V
N
M
K
E
I
V
T----------------
D
K
----
G
A
F
Y
L
V
F
E
Y
M
D
H
---
D
L
---
M
G
L
L
E
S
---
G
---------
L
-
V
-----
H
--
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
-
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
----
R
P
Y
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
----
S
P
----
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
-
K
--
P
K
----
K
Q
------
Y
R
R
R
L
-
R
E
E
---
F
S
F
------------
I
P
S
A
----
A
--------
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
53.47
35%
-25
- C3 -
-
6B3E
3
C:
[8-305]
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
-
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
---
H
R
S
V
V
N
M
K
E
I
V
T----------------
D
K
----
G
A
F
Y
L
V
F
E
Y
M
D
H
---
D
L
---
M
G
L
L
E
S
---
G
---------
L
-
V
-----
H
--
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
-
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
----
R
P
Y
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
----
S
P
----
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
-
K
--
P
K
----
K
Q
------
Y
R
R
R
L
-
R
E
E
---
F
S
F
------------
I
P
S
A
----
A
--------
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
522
Blastp_CBE
53.33
35%
-27
- C3 -
-
4NST
3
C:
[12-309]
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
-
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
---
H
R
S
V
V
N
M
K
E
I
V
T----------------
D
K
----
G
A
F
Y
L
V
F
E
Y
M
D
H
---
D
L
---
M
G
L
L
E
S
---
G
---------
L
-
V
-----
H
--
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
-
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
-
E
S
----
R
P
Y
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
----
S
P
----
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
-
K
--
P
K
----
K
Q
------
Y
R
R
R
L
-
R
E
E
---
F
S
F
------------
I
P
S
A
----
A
--------
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
52.08
41%
-47
- C3 -
-
4D1Z
2
CDK2_HUMAN
A:
[3-287]
--
N
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
------
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
---------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
517
Blastp_CBE
51.76
35%
-13
- C3 -
-
5ACB
1
D:
[12-309]
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
-
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
---
H
R
S
V
V
N
M
K
E
I
V
TDKQFK----
K
------
D
K
----
G
A
F
Y
L
V
F
E
Y
M
D
H
---
D
L
---
M
G
L
L
E
S
---
G
---------
L
-
V
-----
H
--
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
-
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
---
S
----
R
P
Y
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
----
S
P
----
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
-
K
--
P
K
----
K
Q
------
Y
R
R
R
L
-
R
E
E
---
F
S
F
------------
I
P
S
A
----
A
--------
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
533
Blastp_CBE
50.75
37%
-33
- C3 -
-
4TTH
1
CDK6_HUMAN
B:
[15-301]
-----
C
V
A
E
I
G
E
----
K
V
F
K
A
R
D
L
K
N
-
G
R
F
V
A
L
K
R
V
R
V
----
E
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
C
----------
T
------------
T
K
L
T
L
V
F
E
H
V
D
Q
---
D
L
---
T
T
Y
L
D
K
---
V
---------
P
-
E
P----
G
--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
-
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
I
Y
S
F
Q
M
A
----
L
-
T
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
-
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
----------
L
P
G
E
E
D
W
P
------------------------------
P
I
-
E
K
F
-----
D
------------
I
D
E
L
----
G
--------
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
335
Blastp_CBE
45.26
41%
-46
- C3 -
-
4RJ3
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
I
R
L
D
T
E
--------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
336
Blastp_CBE
44.10
41%
-34
- C3 -
-
1OIR
1
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
I
R
------
G
-
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
44.08
41%
-31
- C3 -
-
1H01
3
CDK2_HUMAN
A:
[1-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
I
R
------
G
-
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
I
----------
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
---
D
L
KKF
M
D
A
S
A
L
---------------
T
-----
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
-
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------
P
D
E
V
V
W
P
G
V
T
S
-
M
P
D
----
Y
K
PSFPKW
A
R
Q
D
F
-
S
K
V
---
V
P
P
------------
L
D
E
D
----
G
--------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
----------------------------------------------------------------------------------------------------------