@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDKL4_HUMAN: (2020-09-06 )
MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIHNCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIPEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQEAQIKRKARNEGRNRRRQQQAPKSAFPRLFLKTKICQVQRNETQTSGNQILPNGPILQNSMVTVMTNINSAVYQVTVLHLLSENFEVKS
Atome Classification :
(507 SA)
.........10........20..-......30.....---...40........50........---60........--70.------..----......80........90.-----.---..-.-.--..100.......110.......120.......130..--..-...140.......-150...-.-----...-.160.......170.......180.......190...-....200.......210......----.220.......230.....-..240-.....-...250....-..----.----.------------260.......270.......280....--...290--........300.......310.......320.......330.......340.......350.......360.......370.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
E
K
Y
E
K
L
A
KTGEGS
Y
G
V
V
F
K
CRN-KTS
G
Q
V
V
A
V
K
K
F
V---ESED
D
P
V
V
K
K
I
A
L
R
E
I
R
M
L
K
Q
LK---HP
N
L
V
N
L
I
E
V
--
F
-
R
------
R
K----
R
K
M
H
L
V
F
E
YC
D
H
T
L
L
N
E
L
E-----R---NP-N-G--
V
A
D
G
V
I
K
S
V
L
W
Q
T
L
Q
A
L
N
F
C
H
I
H
N
C
I
H
RDIKPE
N
I
L
I
--TK-Q
G
I
I
K
I
CDFG
F
A
Q
-
I
L
-IPG-D-----A
Y
T
-
D
Y
V
A
T
R
WYRAPE
L
L
V
GDTQYGSSV
D
I
W
A
I
G
C
V
F
A
E
L
L-TGQPLWPGK
S
D
V
D
Q
L
Y
L
I
I
R
T
L
G
----
K
L
I
P
R
H
Q
S
I
F
KSNG
F
F
HGI-SIPE--P
E
D
M
E
-
T
L
E
E
K
-FSDV-
H
P
----
V
----
A
------------
L
N
F
M
K
G
C
LKMNPDDR
L
T
C
S
Q
L
L
E
S
S
Y
F
--
D
S
F
Q
E
---
A
Q
I
K
R
K
A
RNEGRN
R
R
R
Q
QQA
P
K
S
A
F
P
R
L
F
L
K
T
K
I
C
Q
V
QRNETQTSG
N
Q
ILPNGPILQN
S
M
V
T
V
M
TNIN
S
A
V
Y
Q
V
T
V
L
H
L
L
SENFEVKS
1
PsiBlast_PDB
92.77
71%
-137
- C1 -
-
4AGU
1
CDKL1_HUMAN
A:
[3-292]
-
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
-
R
D
T
G
Q
I
V
A
I
K
K
F
L
---
E
S
E
-
D
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
---
H
P
N
L
V
N
L
L
E
V
--
F
-
R
------
R
K
----
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
-----
R
---
Y
Q
-
R
-
G
--
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
--
T
K
-
H
S
V
I
K
L
C
D
F
G
F
A
R
-
L
L
-------------------
T
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
-
S
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
----
D
L
I
P
R
H
Q
Q
V
F
S
T
N
Q
Y
F
S
G
V
-
K
I
P
D
--
P
E
D
M
E
-
P
L
E
L
K
-
F
P
N
I
-
S
Y
----
P
----
A
------------
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
--
E
N
I
R
--------------------------------------------------------------------------------------------
21
Blastp_CBE
92.02
71%
-136
- C1 -
-
4AGU
1
CDKL1_HUMAN
C:
[3-292]
-
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
-
R
D
T
G
Q
I
V
A
I
K
K
F
L
---
E
S
E
D
D
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
---
H
P
N
L
V
N
L
L
E
V
--
F
-
R
------
R
K
----
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
-----
R
---
Y
Q
-
R
-
G
--
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
--
T
K
-
H
S
V
I
K
L
C
D
F
G
F
A
R
-
L
L
-------------------
T
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
-
S
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
----
D
L
I
P
R
H
Q
Q
V
F
S
T
N
Q
Y
F
S
G
V
-
K
I
P
D
--
P
E
D
M
E
-
P
L
E
L
K
-
F
P
N
I
-
S
Y
----
P
----
A
------------
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
--
E
N
I
R
--------------------------------------------------------------------------------------------
22
Blastp_CBE
92.01
71%
-139
- C1 -
-
4AGU
1
CDKL1_HUMAN
B:
[4-293]
--
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
-
R
D
T
G
Q
I
V
A
I
K
K
F
L
---
E
S
--
D
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
---
H
P
N
L
V
N
L
L
E
V
--
F
-
R
------
R
K
----
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
-----
R
---
Y
Q
-
R
-
G
--
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
--
T
K
-
H
S
V
I
K
L
C
D
F
G
F
A
R
-
L
L
-------------------
T
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
-
S
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
----
D
L
I
P
R
H
Q
Q
V
F
S
T
N
Q
Y
F
S
G
V
-
K
I
P
D
--
P
E
D
M
E
-
P
L
E
L
K
-
F
P
N
I
-
S
Y
----
P
----
A
------------
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
--
E
N
I
R
E
-------------------------------------------------------------------------------------------
2
PsiBlast_PDB
87.86
55%
-156
- C1 -
-
4AAA
7
CDKL2_HUMAN
A:
[24-317]
M
E
K
Y
E
N
L
G
L
V
G
E
G
S
Y
G
M
V
M
K
C
R
N
-
K
D
T
G
R
I
V
A
I
K
K
F
L
---
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
---
H
E
N
L
V
N
L
L
E
V
--
C
-
K
------
K
K
----
K
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
-----
L
---
F
P
-
N
-
G
--
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
--
S
Q
-
S
G
V
V
K
L
C
D
F
G
F
A
--------------------
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
-
M
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
----
N
L
I
P
R
H
Q
E
L
F
N
K
N
P
V
F
A
G
V
-
R
L
P
E
--
I
K
E
R
E
-
P
L
E
R
R
-
Y
P
K
L
-
S
E
----
V
----
V
------------
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
QM
D
G
F
A
E
-------------------------------------------------------------------------------------------
561
HHSearch
86.81
54%
-157
- C1 -
-
4AAA
7
CDKL2_HUMAN
A:
[25-316]
-
E
K
Y
E
N
L
G
L
V
G
E
G
S
Y
G
M
V
M
K
C
R
N
-
K
D
T
G
R
I
V
A
I
K
K
F
L
---
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
---
H
E
N
L
V
N
L
L
E
V
--
C
-
K
------
K
K
----
K
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
-----
L
---
F
P
-
N
-
G
--
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
--
S
Q
-
S
G
V
V
K
L
C
D
F
G
F
A
--------------------
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
-
M
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
----
N
L
I
P
R
H
Q
E
L
F
N
K
N
P
V
F
A
G
V
-
R
L
P
E
--
I
K
E
R
E
-
P
L
E
R
R
-
Y
P
K
L
-
S
E
----
V
----
V
------------
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
--
Q
M
D
G
F
---
A
---------------------------------------------------------------------------------------
4
PsiBlast_PDB
83.31
47%
-120
- C1 -
-
3ZDU
3
CDKL3_HUMAN
A:
[2-309]
M
E
M
Y
E
T
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
-
K
N
T
G
Q
I
V
A
I
K
I
F
Y
-----------
N
K
I
A
M
R
E
I
K
F
L
K
Q
F
H
---
H
E
N
L
V
N
L
I
E
V
--
F
-
R
------
Q
K
----
K
K
I
H
L
V
F
E
F
I
D
H
T
V
L
D
E
L
Q
-----
H
---
Y
C
-
H
-
G
--
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
--
S
Q
-
S
G
I
T
K
L
C
D
F
G
F
A
R
-
T
------
D
-----
I
Y
D
-
D
E
V
A
T
R
W
Y
R
A
P
E
L
V
L
K
D
T
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
-
T
G
N
P
Y
L
P
S
S
S
D
L
D
L
L
H
K
I
V
L
K
V
G
----
N
L
S
P
H
L
Q
N
I
F
S
K
S
P
I
F
A
G
V
-
V
L
P
Q
--
V
Q
H
P
K
-
N
A
R
K
K
-
Y
P
K
L
-
N
G
----
L
----
L
------------
A
D
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
TR
D
G
F
I
E
KFM
P
E
L
K
A
K
L
L
Q
E
A
K
----------------------------------------------------------------------------
3
PsiBlast_PDB
83.29
55%
-106
- C1 -
-
4BBM
3
CDKL2_HUMAN
A:
[24-317]
M
E
K
Y
E
N
L
G
L
V
--
G
S
Y
G
M
V
M
K
C
R
N
-
K
D
T
G
R
I
V
A
I
K
K
F
L
---
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
---
H
E
N
L
V
N
L
L
E
V
--
C
-
K
------
K
K
----
K
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
-----
L
---
F
P
-
N
-
G
--
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
--
S
Q
-
S
G
V
V
K
L
C
D
F
G
F
A
R
-
T
L
A
A
P
G
-
E
-----
V
Y
D
-
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
-
M
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
----
N
L
I
P
R
H
Q
E
L
F
N
K
N
P
V
F
A
G
V
-
R
L
P
E
--
I
K
E
R
E
-
P
L
E
R
R
-
Y
P
K
L
-
S
E
----
V
----
V
------------
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
QM
D
G
F
A
E
-------------------------------------------------------------------------------------------
556
HHSearch
81.85
54%
-103
- C1 -
-
4BBM
3
CDKL2_HUMAN
A:
[25-316]
-
E
K
Y
E
N
L
G
L
V
G
--
S
Y
G
M
V
M
K
C
R
N
-
K
D
T
G
R
I
V
A
I
K
K
F
L
---
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
---
H
E
N
L
V
N
L
L
E
V
--
C
-
K
------
K
K
----
K
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
-----
L
---
F
P
-
N
-
G
--
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
--
S
Q
-
S
G
V
V
K
L
C
D
F
G
F
A
R
-
T
L
-
A
A
P
G
E
-----
V
Y
D
-
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
-
M
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
----
N
L
I
P
R
H
Q
E
L
F
N
K
N
P
V
F
A
G
V
-
R
L
P
E
--
I
K
E
R
E
-
P
L
E
R
R
-
Y
P
K
L
-
S
E
----
V
----
V
------------
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
--
Q
M
D
G
F
---
A
---------------------------------------------------------------------------------------
23
Blastp_CBE
75.85
55%
-108
- C1 -
-
4BBM
3
CDKL2_HUMAN
B:
[24-317]
M
E
K
Y
E
N
L
-----
G
S
Y
G
M
V
M
K
C
R
N
-
K
D
T
G
R
I
V
A
I
K
K
F
------------
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
---
H
E
N
L
V
N
L
L
E
V
--
C
-----------------
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
-----
L
---
F
P
-
N
-
G
--
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
--
S
Q
-
S
G
V
V
K
L
C
D
F
G
F
A
R
-
T
L
A
A
P
G
-
E
-----
V
Y
D
-
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
-
M
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
----
N
L
I
P
R
H
Q
E
L
F
N
K
N
P
V
F
A
G
V
-
R
L
P
E
--
I
K
E
R
E
-
P
L
E
R
R
-
Y
P
K
L
-
S
E
----
V
----
V
------------
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
QM
D
G
F
A
E
-------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.47
46%
-115
- C1 -
-
4BGQ
3
CDKL5_HUMAN
A:
[11-300]
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
-
K
E
T
H
E
I
V
A
I
K
K
F
K
----------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
---
Q
E
N
I
V
E
L
K
E
A
--
F
-
R
------
R
R
----
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
-----
E
---
M
P
-
N
-
G
--
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
--
S
H
-
N
D
V
L
K
L
C
D
F
G
F
A
R
-
N
L
-
S
E
----------------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
-
D
G
Q
P
L
F
P
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
L
G
----
P
L
P
S
E
Q
M
K
L
F
Y
S
N
P
R
F
H
G
L
-
R
F
P
A
--
V
N
H
P
Q
-
S
L
E
R
R
-
Y
L
G
I
L
N
S
----
V
----
L
------------
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
--
Q
T
----------------------------------------------------------------------------------------------
133
Blastp_CBE
72.42
40%
-57
- C1 -
-
2EXM
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
562
HHSearch
71.88
46%
-114
- C1 -
-
4BGQ
3
CDKL5_HUMAN
A:
[11-302]
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
-
K
E
T
H
E
I
V
A
I
K
K
F
K
----------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
---
Q
E
N
I
V
E
L
K
E
A
--
F
-
R
------
R
R
----
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
-----
E
---
M
P
-
N
-
G
--
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
--
S
H
-
N
D
V
L
K
L
C
D
F
G
F
A
R
-
N
L
-
S
E
----------------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
-
D
G
Q
P
L
F
P
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
L
G
----
P
L
P
S
E
Q
M
K
L
F
Y
S
N
P
R
F
H
G
L
-
R
F
P
A
--
V
N
H
P
Q
S
L
E
R
R
Y
-
L
G
I
L
-
N
S
----
V
----
L
------------
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
--
Q
T
Q
R
--------------------------------------------------------------------------------------------
309
Blastp_CBE
71.86
40%
-64
- C1 -
-
3QQF
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
70
Blastp_CBE
71.76
40%
-62
- C1 -
-
3UNK
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
183
Blastp_CBE
71.69
40%
-82
- C1 -
-
1KE9
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
151
Blastp_CBE
71.68
40%
-56
- C1 -
-
2C5N
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
250
Blastp_CBE
71.46
40%
-67
- C1 -
-
3RM7
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
164
Blastp_CBE
71.36
40%
-68
- C1 -
-
1Y8Y
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
71.33
40%
-65
- C1 -
-
1GZ8
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
43
Blastp_CBE
71.23
40%
-72
- C1 -
-
4LYN
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
122
Blastp_CBE
71.21
40%
-53
- C1 -
-
2UUE
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
97
Blastp_CBE
71.21
40%
-47
- C1 -
-
2X1N
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
44
Blastp_CBE
71.13
40%
-60
- C1 -
-
4KD1
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
71.06
40%
-63
- C1 -
-
1W8C
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
227
Blastp_CBE
71.03
40%
-61
- C1 -
-
6Q4C
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
187
Blastp_CBE
70.97
40%
-81
- C1 -
-
1KE5
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
137
Blastp_CBE
70.96
40%
-63
- C1 -
-
2C6M
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
276
Blastp_CBE
70.89
40%
-65
- C1 -
-
3R7E
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
532
Blastp_CBE
70.88
34%
-111
- C1 -
-
5G6V
4
CDK16_HUMAN
A:
[1-290]
M
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
-
K
L
T
D
N
L
V
A
L
K
E
-
I
---
R
L
E
H
E
E
G
A
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
--
I
-
H
------
T
E
----
K
S
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
-----
D
---
C
G
-
N
-
I
--
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
-
A
------
K
-----
T
Y
D
-
N
E
V
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
-
T
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
----
T
P
T
E
E
T
W
P
G
I
L
S
N
E
E
F
K
T
Y
-
N
Y
P
K
--
Y
R
-
A
E
-
A
L
L
S
H
-
A
P
R
L
-
D
S
----
D
----
G
------------
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
--
L
S
L
G
E
-------------------------------------------------------------------------------------------
482
Blastp_CBE
70.77
39%
-94
- C1 -
-
1V0P
1
CDC2H_PLAFK
A:
[1-284]
M
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
--
N
Y
G
E
T
F
A
L
K
K
I
R
---
L
E
K
E
D
E
G
I
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
--
I
-
H
------
T
K
----
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
-----
V
---
C
E
-
G
-
G
--
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
-
A
F
G----------------
I
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
TPNS
K
N
W
P
N
V
T
E
L
P
K
Y
D
P
N
F
----
T
V
Y
E
--
P
L
P
W
E
-
S
F
----
L
K
G
L
-
D
E
----
S
----
G
------------
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
--------------------------------------------------------------------------------------------------
186
Blastp_CBE
70.80
40%
-81
- C1 -
-
1KE6
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
279
Blastp_CBE
70.77
40%
-64
- C1 -
-
3R6X
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
246
Blastp_CBE
70.72
40%
-62
- C1 -
-
3RPO
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
331
Blastp_CBE
70.64
40%
-56
- C1 -
-
2BKZ
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
284
Blastp_CBE
70.70
40%
-59
- C1 -
-
3QZI
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
531
Blastp_CBE
70.69
34%
-124
- C1 -
-
5G6V
3
CDK16_HUMAN
B:
[1-290]
M
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
-
K
L
T
D
N
L
V
A
L
K
E
-
I
---
R
L
E
H
E
E
G
A
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
---
H
A
N
I
V
T
L
H
D
I
--
I
-
H
------
T
E
----
K
S
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
-----
D
---
C
G
-
N
-
I
--
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
E
-
R
G
E
L
K
L
A
D
F
G
L
A
R
-
A
-------------------
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
-
T
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
----
T
P
T
E
E
T
W
P
G
I
L
S
N
E
E
F
K
T
Y
-
N
Y
P
K
--
Y
R
-
A
E
-
A
L
L
S
H
-
A
P
R
L
-
D
S
----
D
----
G
------------
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
--
L
S
L
G
E
-------------------------------------------------------------------------------------------
179
Blastp_CBE
70.67
40%
-67
- C1 -
-
1PXI
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
259
Blastp_CBE
70.66
40%
-67
- C1 -
-
3RAI
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
285
Blastp_CBE
70.64
40%
-62
- C1 -
-
3QZH
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
289
Blastp_CBE
70.62
40%
-59
- C1 -
-
3QXO
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
142
Blastp_CBE
70.53
40%
-66
- C1 -
-
2C68
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
185
Blastp_CBE
70.50
40%
-80
- C1 -
-
1KE7
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
271
Blastp_CBE
70.45
40%
-63
- C1 -
-
3R83
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
277
Blastp_CBE
70.48
40%
-68
- C1 -
-
3R73
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
305
Blastp_CBE
70.47
40%
-58
- C1 -
-
3QQK
6
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
123
Blastp_CBE
70.45
40%
-54
- C1 -
-
2UUE
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
120
Blastp_CBE
70.45
40%
-65
- C1 -
-
2UZO
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
199
Blastp_CBE
70.42
40%
-48
- C1 -
-
1FVV
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
263
Blastp_CBE
70.44
40%
-65
- C1 -
-
3R9H
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
139
Blastp_CBE
70.42
40%
-65
- C1 -
-
2C6K
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
283
Blastp_CBE
70.41
40%
-61
- C1 -
-
3R1Q
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
319
Blastp_CBE
70.34
40%
-53
- C1 -
-
2WXV
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
281
Blastp_CBE
70.34
40%
-64
- C1 -
-
3R1Y
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
166
Blastp_CBE
70.33
40%
-79
- C1 -
-
1W0X
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
136
Blastp_CBE
70.32
40%
-68
- C1 -
-
2C6O
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
306
Blastp_CBE
70.26
40%
-64
- C1 -
-
3QQJ
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
192
Blastp_CBE
70.29
40%
-67
- C1 -
-
1H0V
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
----
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
98
Blastp_CBE
70.27
40%
-53
- C1 -
-
2WEV
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
301
Blastp_CBE
70.26
40%
-59
- C1 -
-
3QTQ
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
321
Blastp_CBE
70.19
40%
-50
- C1 -
-
2WPA
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
96
Blastp_CBE
70.23
40%
-51
- C1 -
-
2X1N
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
224
Blastp_CBE
70.22
40%
-60
- C1 -
-
6Q4H
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G--
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
99
Blastp_CBE
70.21
40%
-54
- C1 -
-
2WEV
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
308
Blastp_CBE
70.19
40%
-62
- C1 -
-
3QQG
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
247
Blastp_CBE
70.18
40%
-65
- C1 -
-
3ROY
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
291
Blastp_CBE
70.17
40%
-62
- C1 -
-
3QX2
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
330
Blastp_CBE
70.07
40%
-57
- C1 -
-
2BKZ
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
184
Blastp_CBE
70.10
40%
-68
- C1 -
-
1KE8
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
40
Blastp_CBE
70.07
40%
-63
- C1 -
-
5ANE
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
194
Blastp_CBE
69.96
40%
-66
- C1 -
-
1H07
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-----
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
327
Blastp_CBE
69.92
40%
-53
- C1 -
-
2C4G
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
200
Blastp_CBE
69.98
40%
-65
- C1 -
-
1FVT
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
162
Blastp_CBE
69.96
40%
-59
- C1 -
-
1YKR
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
172
Blastp_CBE
69.95
40%
-58
- C1 -
-
1PXP
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
272
Blastp_CBE
69.92
40%
-59
- C1 -
-
3R7Y
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
270
Blastp_CBE
69.86
40%
-59
- C1 -
-
3R8L
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
165
Blastp_CBE
69.89
40%
-76
- C1 -
-
1WCC
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
150
Blastp_CBE
69.87
40%
-55
- C1 -
-
2C5N
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
135
Blastp_CBE
69.88
40%
-62
- C1 -
-
2CLX
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
102
Blastp_CBE
69.87
40%
-73
- C1 -
-
2W06
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
204
Blastp_CBE
69.86
40%
-64
- C1 -
-
1E1X
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
267
Blastp_CBE
69.85
40%
-64
- C1 -
-
3R8U
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
178
Blastp_CBE
69.80
40%
-63
- C1 -
-
1PXJ
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
73
Blastp_CBE
69.80
40%
-64
- C1 -
-
3TIZ
9
CDK2_HUMAN
A:
[2-286]
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
141
Blastp_CBE
69.79
40%
-63
- C1 -
-
2C69
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
149
Blastp_CBE
69.77
40%
-54
- C1 -
-
2C5O
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
280
Blastp_CBE
69.69
40%
-61
- C1 -
-
3R28
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
173
Blastp_CBE
69.73
40%
-61
- C1 -
-
1PXO
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
328
Blastp_CBE
69.71
40%
-50
- C1 -
-
2BPM
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
148
Blastp_CBE
69.70
40%
-55
- C1 -
-
2C5O
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
190
Blastp_CBE
69.69
40%
-60
- C1 -
-
1HCK
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
119
Blastp_CBE
69.67
40%
-63
- C1 -
-
2V0D
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
314
Blastp_CBE
69.62
40%
-61
- C1 -
-
3PXY
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
69.67
40%
-66
- C1 -
-
2R3I
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
69.67
40%
-63
- C1 -
-
2R3Q
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
157
Blastp_CBE
69.64
40%
-55
- C1 -
-
2B54
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
282
Blastp_CBE
69.62
40%
-59
- C1 -
-
3R1S
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
138
Blastp_CBE
69.58
40%
-58
- C1 -
-
2C6L
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
324
Blastp_CBE
69.56
40%
-54
- C1 -
-
2WIH
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
111
Blastp_CBE
69.52
40%
-73
- C1 -
-
2VTO
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
---------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
91
Blastp_CBE
69.48
40%
-53
- C1 -
-
3EJ1
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
302
Blastp_CBE
69.44
40%
-50
- C1 -
-
3QRU
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
376
Blastp_CBE
69.43
40%
-73
- C1 -
-
1V0O
1
CDC2H_PLAFK
A:
[3-284]
--
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
--
N
Y
G
E
T
F
A
L
K
K
I
R
---
L
--------
S
T
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
--
I
-
H
------
T
K
----
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
-----
V
---
C
E
-
G
-
G
--
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
-
A
F
G
I
P
V
-
R
-----
K
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
TPNS
K
N
W
P
N
V
T
E
L
P
K
Y
D
P
N
F
----
T
V
Y
E
--
P
L
P
W
E
-
S
F
----
L
K
G
L
-
D
E
----
S
----
G
------------
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
--------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
69.42
40%
-63
- C1 -
-
2R3O
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
237
Blastp_CBE
69.38
40%
-59
- C1 -
-
4EZ3
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
191
Blastp_CBE
69.41
40%
-67
- C1 -
-
1H0W
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
296
Blastp_CBE
69.40
40%
-57
- C1 -
-
3QTX
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
95
Blastp_CBE
69.38
40%
-63
- C1 -
-
2XMY
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
---
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
82
Blastp_CBE
69.38
40%
-68
- C1 -
-
3LFN
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
----------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
307
Blastp_CBE
69.37
40%
-59
- C1 -
-
3QQH
4
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
79
Blastp_CBE
69.36
40%
-62
- C1 -
-
3NS9
1
CDK2_HUMAN
A:
[3-286]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
----------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
49
Blastp_CBE
69.36
40%
-60
- C1 -
-
4FKU
3
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
53
Blastp_CBE
69.35
40%
-63
- C1 -
-
4FKQ
2
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
313
Blastp_CBE
69.30
40%
-46
- C1 -
-
3PXZ
3
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
333
Blastp_CBE
69.28
40%
-51
- C1 -
-
1VYW
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
320
Blastp_CBE
69.26
40%
-50
- C1 -
-
2WPA
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
312
Blastp_CBE
69.20
40%
-61
- C1 -
-
3PY0
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
344
Blastp_CBE
69.18
39%
-43
- C1 -
-
6GU2
1
CDK1_HUMAN
A:
[6-299]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
---
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
--
L
-
M
------
Q
D
----
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
-----
S
---
I
P
-
P
-
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
D
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
-
A
F
G
I
P
I
-
R
-----
V
Y
T
----
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
------
T
P
N
N
E
-------------
V
W
P
E
--
V
E
S
L
Q
-
D
Y
K
N
T
-
F
P
K
W
-
K
P
----
G
----
S
LASHVKNLDENG
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
--
N
D
L
-
D
---
N
Q
I
-------------------------------------------------------------------------------------
254
Blastp_CBE
69.20
40%
-57
- C1 -
-
3RK7
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
342
Blastp_CBE
69.24
39%
-41
- C1 -
-
6GU4
1
CDK1_HUMAN
A:
[6-294]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
---
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
--
L
-
M
------
Q
D
----
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
-----
S
---
I
P
-
P
-
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
D
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
-
A
F
G
I
P
I
-
R
-----
V
Y
T
-
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
------
T
P
N
N
E
-------------
V
W
P
E
--
V
E
S
L
Q
-
D
Y
K
N
T
-
F
P
K
W
-
K
P
----
G
----
S
LASHVKNLDENG
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
--
N
D
----------------------------------------------------------------------------------------------
295
Blastp_CBE
69.22
40%
-59
- C1 -
-
3QTZ
3
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
209
Blastp_CBE
69.18
40%
-66
- C1 -
-
1B39
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
87
Blastp_CBE
69.20
40%
-54
- C1 -
-
3F5X
2
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
121
Blastp_CBE
69.18
40%
-75
- C1 -
-
2UZN
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
335
Blastp_CBE
69.17
39%
-79
- C1 -
-
3NIZ
1
?
A:
[20-304]
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
--
S
Q
G
R
I
V
A
L
K
R
I
R
---------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
---
H
P
N
I
V
S
L
I
D
V
--
I
-
H
------
S
E
----
R
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
-----
E
---
N
K
-
T
-
G
--
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
S
-
D
G
A
L
K
L
A
D
F
G
L
A
R
-
A
F
G
I
P
V
-
R
---------
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
-
T
G
K
P
L
F
P
G
V
T
D
D
D
Q
L
P
K
I
F
S
I
L
G
----
T
P
N
P
R
E
W
P
Q
V
Q
E
------
L
-
P
L
W
K
--
Q
R
T
F
Q
-
V
F
E
K
K
P
W
S
S
I
-
I
P
GFCQ
E
----
G
------------
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
--------------------------------------------------------------------------------------------------
174
Blastp_CBE
69.10
40%
-54
- C1 -
-
1PXN
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
228
Blastp_CBE
69.08
40%
-60
- C1 -
-
6Q4B
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
71
Blastp_CBE
69.10
40%
-60
- C1 -
-
3UNJ
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
198
Blastp_CBE
69.09
40%
-48
- C1 -
-
1FVV
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
54
Blastp_CBE
69.08
40%
-73
- C1 -
-
4FKP
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
69.08
40%
-65
- C1 -
-
2R3P
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
89
Blastp_CBE
69.06
40%
-54
- C1 -
-
3EOC
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
62
Blastp_CBE
69.06
40%
-61
- C1 -
-
4EK5
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
265
Blastp_CBE
69.05
40%
-61
- C1 -
-
3R8Z
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
----------
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
107
Blastp_CBE
69.04
40%
-71
- C1 -
-
2VTS
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
---------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
74
Blastp_CBE
69.03
40%
-62
- C1 -
-
3TIY
12
CDK2_HUMAN
A:
[2-286]
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
189
Blastp_CBE
69.01
40%
-58
- C1 -
-
1JSV
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
310
Blastp_CBE
69.00
40%
-59
- C1 -
-
3QL8
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
161
Blastp_CBE
68.99
40%
-61
- C1 -
-
2A0C
1
CDK2_HUMAN
X:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
343
Blastp_CBE
68.92
39%
-40
- C1 -
-
6GU3
1
CDK1_HUMAN
A:
[6-294]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
---
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
--
L
-
M
------
Q
D
----
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
-----
S
---
I
P
-
P
-
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
D
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
-
A
F
G
I
P
I
-
R
-----
V
Y
T
-
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
------
T
P
N
N
E
-------------
V
W
P
E
--
V
E
S
L
Q
-
D
Y
K
N
T
-
F
P
K
W
-
K
P
----
G
----
S
LASHVKNLDENG
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
--
N
D
----------------------------------------------------------------------------------------------
222
Blastp_CBE
68.94
40%
-57
- C1 -
-
6Q4K
3
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
353
Blastp_CBE
68.96
40%
-58
- C1 -
-
5OO3
1
CDK2_HUMAN
A:
[7-291]
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
287
Blastp_CBE
68.95
40%
-62
- C1 -
-
3QZF
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
147
Blastp_CBE
68.94
40%
-56
- C1 -
-
2C5V
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
117
Blastp_CBE
68.92
40%
-77
- C1 -
-
2VTH
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
318
Blastp_CBE
68.87
40%
-53
- C1 -
-
2WXV
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
56
Blastp_CBE
68.92
40%
-64
- C1 -
-
4FKL
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
244
Blastp_CBE
68.88
40%
-56
- C1 -
-
3RPV
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
210
Blastp_CBE
68.91
40%
-65
- C1 -
-
1B38
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
286
Blastp_CBE
68.89
40%
-66
- C1 -
-
3QZG
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
127
Blastp_CBE
68.88
40%
-61
- C1 -
-
2R3G
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
304
Blastp_CBE
68.87
40%
-53
- C1 -
-
3QQL
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
92
Blastp_CBE
68.85
40%
-52
- C1 -
-
3EJ1
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
45
Blastp_CBE
68.84
40%
-47
- C1 -
-
4FX3
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
235
Blastp_CBE
68.79
40%
-47
- C1 -
-
4GCJ
5
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
158
Blastp_CBE
68.81
40%
-56
- C1 -
-
2B53
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
108
Blastp_CBE
68.79
40%
-58
- C1 -
-
2VTR
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
329
Blastp_CBE
68.71
40%
-52
- C1 -
-
2BPM
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
41
Blastp_CBE
68.76
40%
-80
- C1 -
-
5AND
1
CDK2_HUMAN
A:
[2-286]
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
241
Blastp_CBE
68.75
40%
-64
- C1 -
-
3S00
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
317
Blastp_CBE
68.72
40%
-47
- C1 -
-
3PXF
7
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
268
Blastp_CBE
68.71
40%
-57
- C1 -
-
3R8P
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
273
Blastp_CBE
68.64
40%
-60
- C1 -
-
3R7V
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
205
Blastp_CBE
68.66
40%
-63
- C1 -
-
1E1V
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
207
Blastp_CBE
68.65
40%
-75
- C1 -
-
1DI8
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
90
Blastp_CBE
68.64
40%
-52
- C1 -
-
3EOC
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
86
Blastp_CBE
68.64
40%
-60
- C1 -
-
3FZ1
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G--------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
208
Blastp_CBE
68.61
40%
-78
- C1 -
-
1CKP
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
63
Blastp_CBE
68.63
40%
-60
- C1 -
-
4EK4
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
32
Blastp_CBE
68.63
40%
-66
- C1 -
-
5IEV
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
126
Blastp_CBE
68.60
40%
-61
- C1 -
-
2R3H
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
37
Blastp_CBE
68.61
40%
-62
- C1 -
-
5ANJ
1
CDK2_HUMAN
A:
[3-286]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
84
Blastp_CBE
68.60
40%
-66
- C1 -
-
3IGG
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
278
Blastp_CBE
68.58
40%
-63
- C1 -
-
3R71
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
266
Blastp_CBE
68.53
40%
-63
- C1 -
-
3R8V
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
252
Blastp_CBE
68.52
40%
-60
- C1 -
-
3RKB
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
293
Blastp_CBE
68.55
40%
-58
- C1 -
-
3QWJ
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
253
Blastp_CBE
68.50
40%
-55
- C1 -
-
3RK9
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
290
Blastp_CBE
68.48
40%
-58
- C1 -
-
3QX4
3
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
93
Blastp_CBE
68.53
40%
-53
- C1 -
-
3EID
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
124
Blastp_CBE
68.52
40%
-76
- C1 -
-
2R64
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
31
Blastp_CBE
68.51
40%
-69
- C1 -
-
5IEX
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
140
Blastp_CBE
68.50
40%
-66
- C1 -
-
2C6I
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
248
Blastp_CBE
68.49
40%
-53
- C1 -
-
3RNI
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
146
Blastp_CBE
68.48
40%
-49
- C1 -
-
2C5V
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
245
Blastp_CBE
68.47
40%
-70
- C1 -
-
3RPR
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
128
Blastp_CBE
68.44
40%
-64
- C1 -
-
2R3F
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
144
Blastp_CBE
68.40
40%
-53
- C1 -
-
2C5X
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
350
Blastp_CBE
68.32
40%
-57
- C1 -
-
6Q4F
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
K
-
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
348
Blastp_CBE
68.37
39%
-40
- C1 -
-
4YC3
1
CDK1_HUMAN
A:
[6-301]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
---
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
--
L
-
M
------
Q
D
----
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
-----
S
---
I
P
-
P
-
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
D
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
-
A
F
G
I
P
I
-
R
-----
V
Y
T
----
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
------
T
P
N
N
E
-------------
V
W
P
E
--
V
E
S
L
Q
-
D
Y
K
N
T
-
F
P
K
W
-
K
P
----
G
----
S
LASHVKNLDENG
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
--
N
D
L
-
D
---
N
Q
I
K
K
-----------------------------------------------------------------------------------
130
Blastp_CBE
68.36
40%
-56
- C1 -
-
2I40
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
143
Blastp_CBE
68.35
40%
-63
- C1 -
-
2C5Y
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
----------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
30
Blastp_CBE
68.34
40%
-68
- C1 -
-
5IEY
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
260
Blastp_CBE
68.32
40%
-71
- C1 -
-
3RAH
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
325
Blastp_CBE
68.30
40%
-51
- C1 -
-
2WIH
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
100
Blastp_CBE
68.29
40%
-67
- C1 -
-
2W1H
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
297
Blastp_CBE
68.23
40%
-52
- C1 -
-
3QTW
6
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
264
Blastp_CBE
68.18
40%
-56
- C1 -
-
3R9D
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
292
Blastp_CBE
68.22
40%
-59
- C1 -
-
3QWK
5
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
255
Blastp_CBE
68.17
40%
-56
- C1 -
-
3RK5
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
262
Blastp_CBE
68.20
40%
-66
- C1 -
-
3R9N
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
288
Blastp_CBE
68.14
40%
-55
- C1 -
-
3QXP
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
114
Blastp_CBE
68.18
40%
-60
- C1 -
-
2VTL
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
238
Blastp_CBE
68.14
40%
-61
- C1 -
-
3SQQ
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
--------
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
68.17
40%
-61
- C1 -
-
6Q3C
1
CDK2_HUMAN
A:
[10-294]
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
46
Blastp_CBE
68.15
40%
-44
- C1 -
-
4FX3
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
232
Blastp_CBE
68.14
40%
-65
- C1 -
-
6Q3B
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
326
Blastp_CBE
68.13
40%
-55
- C1 -
-
2C4G
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
60
Blastp_CBE
68.11
40%
-72
- C1 -
-
4EK8
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
160
Blastp_CBE
68.08
40%
-59
- C1 -
-
2A4L
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
125
Blastp_CBE
68.08
40%
-65
- C1 -
-
2R3R
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
110
Blastp_CBE
68.07
40%
-76
- C1 -
-
2VTP
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
118
Blastp_CBE
68.05
40%
-76
- C1 -
-
2VTA
3
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
75
Blastp_CBE
68.05
40%
-60
- C1 -
-
3TI1
8
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
104
Blastp_CBE
68.02
40%
-72
- C1 -
-
2VV9
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
131
Blastp_CBE
68.00
40%
-57
- C1 -
-
2I40
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
116
Blastp_CBE
68.00
40%
-77
- C1 -
-
2VTI
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
294
Blastp_CBE
67.98
40%
-55
- C1 -
-
3QU0
5
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
55
Blastp_CBE
67.95
40%
-52
- C1 -
-
4FKO
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
229
Blastp_CBE
67.94
40%
-57
- C1 -
-
6Q4A
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
-
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
201
Blastp_CBE
67.93
40%
-52
- C1 -
-
1FIN
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
349
Blastp_CBE
67.85
39%
-43
- C1 -
-
4Y72
1
CDK1_HUMAN
A:
[6-294]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
---
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
--
L
-
M
------
Q
D
----
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
-----
S
---
I
P
-
P
-
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
D
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
-
A
F
G
I
P
I
-
R
-----
V
Y
T
-
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
------
T
P
N
N
E
-------------
V
W
P
E
--
V
E
S
L
Q
-
D
Y
K
N
T
-
F
P
K
W
-
K
P
----
G
----
S
LASHVKNLDENG
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
--
N
D
----------------------------------------------------------------------------------------------
347
Blastp_CBE
67.85
39%
-43
- C1 -
-
5HQ0
1
CDK1_HUMAN
A:
[6-294]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
---
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
--
L
-
M
------
Q
D
----
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
-----
S
---
I
P
-
P
-
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
D
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
-
A
F
G
I
P
I
-
R
-----
V
Y
T
-
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
------
T
P
N
N
E
-------------
V
W
P
E
--
V
E
S
L
Q
-
D
Y
K
N
T
-
F
P
K
W
-
K
P
----
G
----
S
LASHVKNLDENG
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
--
N
D
----------------------------------------------------------------------------------------------
50
Blastp_CBE
67.92
40%
-72
- C1 -
-
4FKT
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
256
Blastp_CBE
67.90
40%
-58
- C1 -
-
3RJC
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
299
Blastp_CBE
67.86
40%
-66
- C1 -
-
3QTS
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
180
Blastp_CBE
67.85
40%
-54
- C1 -
-
1PF8
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
226
Blastp_CBE
67.80
40%
-58
- C1 -
-
6Q4D
6
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
85
Blastp_CBE
67.81
40%
-73
- C1 -
-
3IG7
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
-------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
202
Blastp_CBE
67.80
40%
-48
- C1 -
-
1FIN
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
72
Blastp_CBE
67.77
40%
-66
- C1 -
-
3ULI
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
-----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
311
Blastp_CBE
67.69
40%
-42
- C1 -
-
3PY1
4
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
52
Blastp_CBE
67.69
40%
-63
- C1 -
-
4FKR
2
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
303
Blastp_CBE
67.67
40%
-49
- C1 -
-
3QRT
3
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
352
Blastp_CBE
67.58
40%
-51
- C1 -
-
5OSM
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
217
Blastp_CBE
67.58
40%
-70
- C1 -
-
3EZV
1
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
332
Blastp_CBE
67.53
40%
-52
- C1 -
-
1VYW
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
77
Blastp_CBE
67.58
40%
-62
- C1 -
-
3SW4
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
213
Blastp_CBE
67.55
40%
-72
- C1 -
-
5K4J
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
223
Blastp_CBE
67.57
40%
-61
- C1 -
-
6Q4J
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
--------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G--
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
47
Blastp_CBE
67.55
40%
-75
- C1 -
-
4FKW
2
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
48
Blastp_CBE
67.53
40%
-67
- C1 -
-
4FKV
2
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
216
Blastp_CBE
67.52
40%
-75
- C1 -
-
1GII
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
H
V
H
Q
D
L
K
T
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
341
Blastp_CBE
67.43
39%
-41
- C1 -
-
6GU6
1
CDK1_HUMAN
A:
[6-296]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
---
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
---
H
P
N
I
V
S
L
Q
D
V
--
L
-
M
------
Q
D
----
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
-----
S
---
I
P
-
P
-
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
D
D
-
K
G
T
I
K
L
A
D
F
G
L
A
R
-
A
F
G
I
P
I
---------
T
-
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
------
T
P
N
N
E
-------------
V
W
P
E
--
V
E
S
L
Q
-
D
Y
K
N
T
-
F
P
K
W
-
K
P
----
G
----
S
LASHVKNLDENG
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
--
N
D
L
-
D
-------------------------------------------------------------------------------------------
274
Blastp_CBE
67.39
40%
-65
- C1 -
-
3R7U
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
251
Blastp_CBE
67.44
40%
-57
- C1 -
-
3RM6
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
-
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
59
Blastp_CBE
67.47
40%
-54
- C1 -
-
4FKG
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G----
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
145
Blastp_CBE
67.45
40%
-50
- C1 -
-
2C5X
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
28
Blastp_CBE
67.44
40%
-77
- C1 -
-
5JQ8
1
CDK2_HUMAN
A:
[3-286]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
240
Blastp_CBE
67.43
40%
-62
- C1 -
-
3S0O
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
--
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
298
Blastp_CBE
67.42
40%
-53
- C1 -
-
3QTU
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
233
Blastp_CBE
67.39
40%
-65
- C1 -
-
6GUK
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
175
Blastp_CBE
67.38
40%
-60
- C1 -
-
1PXM
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
94
Blastp_CBE
67.37
40%
-56
- C1 -
-
2XNB
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
--
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
58
Blastp_CBE
67.36
40%
-53
- C1 -
-
4FKI
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G----
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
159
Blastp_CBE
67.35
40%
-70
- C1 -
-
2B52
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-------------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
38
Blastp_CBE
67.34
40%
-66
- C1 -
-
5ANI
1
CDK2_HUMAN
A:
[2-286]
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
225
Blastp_CBE
67.32
40%
-61
- C1 -
-
6Q4E
3
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
236
Blastp_CBE
67.27
40%
-39
- C1 -
-
4EZ7
7
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
322
Blastp_CBE
67.24
40%
-57
- C1 -
-
2WIP
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
69
Blastp_CBE
67.21
40%
-65
- C1 -
-
3WBL
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
T
G
E
V
V
A
L
K
K
I
R
---
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
169
Blastp_CBE
67.20
40%
-78
- C1 -
-
1URW
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
81
Blastp_CBE
67.18
40%
-54
- C1 -
-
3LFQ
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
261
Blastp_CBE
67.15
40%
-59
- C1 -
-
3R9O
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
176
Blastp_CBE
67.04
40%
-63
- C1 -
-
1PXL
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
275
Blastp_CBE
67.03
40%
-65
- C1 -
-
3R7I
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
88
Blastp_CBE
67.02
40%
-56
- C1 -
-
3F5X
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
-
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
57
Blastp_CBE
67.01
40%
-70
- C1 -
-
4FKJ
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
481
Blastp_CBE
66.91
39%
-107
- C1 -
-
1V0P
1
CDC2H_PLAFK
B:
[2-284]
-
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
--
N
Y
G
E
T
F
A
L
K
--------------
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
--
I
-
H
------
T
-------
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
-----
V
---
C
E
-
G
-
G
--
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
-
A
F
--------------------
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
TPNS
K
N
W
P
N
V
T
E
L
P
K
Y
D
P
N
F
----
T
V
Y
E
--
P
L
P
W
E
-
S
F
----
L
K
G
L
-
D
E
----
S
----
G
------------
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
--------------------------------------------------------------------------------------------------
316
Blastp_CBE
66.94
40%
-44
- C1 -
-
3PXQ
4
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
195
Blastp_CBE
66.91
40%
-71
- C1 -
-
1H00
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
113
Blastp_CBE
66.91
40%
-61
- C1 -
-
2VTM
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
502
Blastp_CBE
66.77
38%
-40
- C1 -
-
1UNL
1
CDK5_HUMAN
A:
[1-289]
M
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
---
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
--
L
-
H
------
S
D
----
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
-----
S
---
C
N
-
G
-
D
--
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
-
A
F
G
I
P
V
-
R
-----
C
Y
S
-
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
------
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
-
P
Y
P
M
--
Y
P
A
T
T
-
S
L
V
N
V
-
V
P
K
L
-
N
A
----
T
----
G
------------
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--
S
D
F
---------------------------------------------------------------------------------------------
196
Blastp_CBE
66.85
40%
-67
- C1 -
-
1GIH
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
66
Blastp_CBE
66.83
40%
-66
- C1 -
-
4BZD
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
80
Blastp_CBE
66.82
40%
-55
- C1 -
-
3LFS
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
36
Blastp_CBE
66.82
40%
-81
- C1 -
-
5ANK
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
--------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
-------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
339
Blastp_CBE
66.72
40%
-59
- C1 -
-
5MHQ
1
?
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
I
R
L
-------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
101
Blastp_CBE
66.77
40%
-74
- C1 -
-
2W17
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
-
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
-----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
-----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
193
Blastp_CBE
66.75
40%
-56
- C1 -
-
1H08
2
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G--------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
29
Blastp_CBE
66.72
40%
-58
- C1 -
-
5JQ5
1
CDK2_HUMAN
A:
[3-286]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
115
Blastp_CBE
66.68
40%
-70
- C1 -
-
2VTJ
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
66.67
40%
-70
- C1 -
-
2R3L
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
-----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
231
Blastp_CBE
66.60
40%
-64
- C1 -
-
6Q48
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
--------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
507
Blastp_CBE
66.58
39%
-42
- C1 -
-
4AU8
2
CDK5_HUMAN
B:
[6-293]
-
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
---
L
----
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
--
L
-
H
------
S
-----
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
-----
S
---
C
N
-
G
-
D
--
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
-
A
F
G
I
P
V
-------------
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
------
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
-
P
Y
P
M
--
Y
P
A
T
T
-
S
L
V
N
V
-
V
P
K
L
-
N
A
----
T
----
G
------------
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--
S
D
F
---------------------------------------------------------------------------------------------
129
Blastp_CBE
66.51
40%
-68
- C1 -
-
2J9M
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
177
Blastp_CBE
66.48
40%
-60
- C1 -
-
1PXK
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
67
Blastp_CBE
66.48
40%
-74
- C1 -
-
4BGH
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
76
Blastp_CBE
66.47
40%
-70
- C1 -
-
3SW7
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
323
Blastp_CBE
66.45
40%
-54
- C1 -
-
2WIP
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
242
Blastp_CBE
66.37
40%
-55
- C1 -
-
3RZB
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
354
Blastp_CBE
66.31
40%
-74
- C1 -
-
5OO1
1
CDK2_HUMAN
A:
[9-291]
---
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
-------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
103
Blastp_CBE
66.37
40%
-69
- C1 -
-
2W05
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
---------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
78
Blastp_CBE
66.35
40%
-75
- C1 -
-
3S2P
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
66.31
40%
-69
- C1 -
-
2R3M
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
61
Blastp_CBE
66.29
40%
-67
- C1 -
-
4EK6
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
243
Blastp_CBE
66.27
40%
-68
- C1 -
-
3RPY
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
167
Blastp_CBE
66.22
40%
-58
- C1 -
-
1VYZ
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
33
Blastp_CBE
66.21
40%
-64
- C1 -
-
5FP6
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
156
Blastp_CBE
66.19
40%
-67
- C1 -
-
2B55
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
----------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
-----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
66.19
40%
-64
- C1 -
-
4NJ3
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
--------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
168
Blastp_CBE
66.17
40%
-73
- C1 -
-
1V1K
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
---------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
83
Blastp_CBE
66.16
40%
-54
- C1 -
-
3LE6
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
66.16
40%
-51
- C1 -
-
6Q4I
2
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
A
F
L
-----
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
163
Blastp_CBE
66.15
40%
-59
- C1 -
-
1Y91
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G-----------
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
152
Blastp_CBE
66.12
40%
-71
- C1 -
-
2BTS
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
300
Blastp_CBE
66.11
40%
-57
- C1 -
-
3QTR
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
68
Blastp_CBE
66.07
40%
-66
- C1 -
-
4ACM
3
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
25
Blastp_CBE
66.06
40%
-74
- C1 -
-
1OIT
1
CDK2_HUMAN
A:
[3-286]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
-
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
S
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
66.00
40%
-70
- C1 -
-
2R3J
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
258
Blastp_CBE
65.94
40%
-68
- C1 -
-
3RAK
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
508
Blastp_CBE
65.96
39%
-40
- C1 -
-
4AU8
2
CDK5_HUMAN
A:
[6-293]
-
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
------------
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
--
L
-
H
-------------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
-----
S
---
C
N
-
G
-
D
--
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
R
-
N
G
E
L
K
L
A
D
F
G
L
A
R
-
A
F
G
I
P
V
-
R
-------
S
-
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
------
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
-
P
Y
P
M
--
Y
P
A
T
T
-
S
L
V
N
V
-
V
P
K
L
-
N
A
----
T
----
G
------------
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--
S
D
F
---------------------------------------------------------------------------------------------
51
Blastp_CBE
65.94
40%
-68
- C1 -
-
4FKS
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
269
Blastp_CBE
65.93
40%
-60
- C1 -
-
3R8M
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
153
Blastp_CBE
65.90
40%
-69
- C1 -
-
2BTR
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
--------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
197
Blastp_CBE
65.87
40%
-72
- C1 -
-
1G5S
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
249
Blastp_CBE
65.86
40%
-62
- C1 -
-
3RMF
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
239
Blastp_CBE
65.76
40%
-67
- C1 -
-
3S1H
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
375
Blastp_CBE
65.57
40%
-66
- C1 -
-
1V0O
1
CDC2H_PLAFK
B:
[3-284]
--
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
--
N
Y
G
E
T
F
A
L
K
K
I
R
---
L
----------
T
I
R
E
I
S
I
L
K
E
L
K
---
H
S
N
I
V
K
L
Y
D
V
--
I
-
H
------
T
K
----
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
-----
V
---
C
E
-
G
-
G
--
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
R
-
E
G
E
L
K
I
A
D
F
G
L
A
R
-
A
F
G
I
P
V
-
R
-----
K
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
-
N
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
TPNS
K
N
W
P
N
V
T
E
L
P
K
Y
D
P
N
F
----
T
V
Y
E
--
P
L
P
W
E
-
S
F
----
L
K
G
L
-
D
E
----
S
----
G
------------
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
--------------------------------------------------------------------------------------------------
65
Blastp_CBE
65.61
40%
-62
- C1 -
-
4D1X
1
CDK2_HUMAN
A:
[3-286]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
65.57
40%
-71
- C1 -
-
2R3K
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
476
Blastp_CBE
65.52
40%
-51
- C1 -
-
1H1R
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
461
Blastp_CBE
65.39
40%
-56
- C1 -
-
4CFU
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
443
Blastp_CBE
65.19
40%
-55
- C1 -
-
3MY5
3
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
170
Blastp_CBE
65.09
40%
-68
- C1 -
-
1R78
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
---------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
433
Blastp_CBE
64.99
40%
-51
- C1 -
-
4BCP
1
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
257
Blastp_CBE
65.07
40%
-71
- C1 -
-
3RAL
1
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
449
Blastp_CBE
65.05
40%
-56
- C1 -
-
3BHT
1
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
447
Blastp_CBE
64.92
40%
-52
- C1 -
-
3BHU
1
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
212
Blastp_CBE
64.99
40%
-71
- C1 -
-
6INL
1
?
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
-----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
234
Blastp_CBE
64.92
40%
-58
- C1 -
-
6GUH
3
CDK2_HUMAN
A:
[9-294]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
--------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
----------
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
408
Blastp_CBE
64.90
40%
-50
- C1 -
-
3DDP
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
509
Blastp_CBE
64.89
37%
-38
- C1 -
-
4KRC
1
PHO85_YEAST
A:
[6-300]
--
Q
F
K
Q
L
E
K
L
G
N
G
T
Y
A
T
V
Y
K
G
L
N
-
K
T
T
G
V
Y
V
A
L
K
E
-
V
---
K
L
D
S
E
E
G
T
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
---
H
E
N
I
V
R
L
Y
D
V
--
I
-
H
------
T
E
----
N
K
L
T
L
V
F
E
F
M
D
N
D
L
K
K
Y
M
D
SR-------
T
P
-
R
-
G
--
L
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
K
-
R
G
Q
L
K
L
G
D
F
G
L
A
R
-
A
F
G
I
P
V
-
N
-----
T
F
S
-
S
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
-
T
G
K
P
L
F
P
G
T
N
D
E
E
Q
L
K
L
I
F
D
I
M
G
TPNE
S
L
W
P
---
S
V
T
K
L
P
K
Y
N
P
N
I
-
Q
Q
R
P
--
P
R
D
L
R
-
Q
V
L
Q
P
-
H
T
K
--
E
P
----
L
DGN-
L
------------
M
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
--
A
E
Y
---------------------------------------------------------------------------------------------
206
Blastp_CBE
64.88
40%
-67
- C1 -
-
1DM2
5
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
406
Blastp_CBE
64.87
40%
-53
- C1 -
-
3DDQ
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
382
Blastp_CBE
64.78
40%
-47
- C1 -
-
2UZE
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
435
Blastp_CBE
64.82
40%
-47
- C1 -
-
4BCO
1
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
154
Blastp_CBE
64.78
40%
-66
- C1 -
-
2BHH
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
112
Blastp_CBE
64.77
40%
-63
- C1 -
-
2VTN
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
389
Blastp_CBE
64.74
40%
-55
- C1 -
-
2C6T
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
134
Blastp_CBE
64.69
40%
-67
- C1 -
-
2DUV
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
----------------
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
401
Blastp_CBE
64.68
40%
-54
- C1 -
-
5LMK
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
465
Blastp_CBE
64.58
40%
-50
- C1 -
-
5CYI
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
426
Blastp_CBE
64.66
40%
-51
- C1 -
-
2IW6
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
463
Blastp_CBE
64.65
40%
-53
- C1 -
-
5NEV
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
506
Blastp_CBE
64.55
38%
-50
- C1 -
-
1UNG
1
CDK5_HUMAN
A:
[1-289]
M
Q
K
Y
E
K
L
E
K
I
----
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
---
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
--
L
-
H
------
S
D
----
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
-----
S
---
C
N
-
G
-
D
--
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
-
A
F
G
I
P
V
-
R
-----
C
Y
S
-
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
------
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
-
P
Y
P
M
--
Y
P
A
T
T
-
S
L
V
N
V
-
V
P
K
L
-
N
A
----
T
----
G
------------
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--
S
D
F
---------------------------------------------------------------------------------------------
368
Blastp_CBE
64.63
40%
-51
- C1 -
-
4EOJ
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
410
Blastp_CBE
64.50
40%
-50
- C1 -
-
2G9X
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
360
Blastp_CBE
64.57
40%
-55
- C1 -
-
4EOO
1
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
459
Blastp_CBE
64.55
40%
-53
- C1 -
-
4CFV
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
42
Blastp_CBE
64.50
40%
-53
- C1 -
-
5A14
2
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
--
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
418
Blastp_CBE
64.49
40%
-53
- C1 -
-
1P5E
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
462
Blastp_CBE
64.47
40%
-51
- C1 -
-
5NEV
1
?
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
218
Blastp_CBE
64.41
40%
-61
- C1 -
-
3EZR
2
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
--------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
441
Blastp_CBE
64.42
40%
-56
- C1 -
-
3TNW
1
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
215
Blastp_CBE
64.41
40%
-62
- C1 -
-
1GIJ
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
H
V
H
Q
D
L
K
T
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
445
Blastp_CBE
64.30
40%
-56
- C1 -
-
3BHV
2
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
378
Blastp_CBE
64.29
40%
-51
- C1 -
-
4II5
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
489
Blastp_CBE
64.26
40%
-58
- C1 -
-
6GUB
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
496
Blastp_CBE
64.25
40%
-55
- C1 -
-
1OI9
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
422
Blastp_CBE
64.24
40%
-47
- C1 -
-
4I3Z
4
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
105
Blastp_CBE
64.19
40%
-51
- C1 -
-
2VU3
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
---------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
-----
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
457
Blastp_CBE
64.18
40%
-55
- C1 -
-
4BCM
1
CDK2_HUMAN
A:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
497
Blastp_CBE
64.07
40%
-53
- C1 -
-
1OI9
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
-
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
499
Blastp_CBE
64.16
40%
-53
- C1 -
-
1OGU
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
390
Blastp_CBE
64.15
40%
-46
- C1 -
-
2C6T
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
402
Blastp_CBE
64.14
40%
-52
- C1 -
-
5L2W
2
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
520
Blastp_CBE
64.11
36%
-19
- C1 -
-
2EUF
2
CDK6_HUMAN
B:
[11-305]
-
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
---
V
Q
T
G
E
E
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
--
C
-
T
VSRTD-
R
E
----
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
-----
K
---
V
P
-
E
P
G
--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
--
T
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
-
I
Y
-
S
F
Q
-
M
-----
A
L
T
-
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
-
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
LPGE
E
D
W
P
-------------------------
A
Q
-
P
I
E
K
F
-
V
T
D
I
-
D
E
----
L
----
G
------------
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--
Q
D
L
E
R
-------------------------------------------------------------------------------------------
473
Blastp_CBE
64.00
40%
-50
- C1 -
-
1H1S
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
384
Blastp_CBE
64.07
40%
-49
- C1 -
-
2UZD
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
109
Blastp_CBE
64.05
40%
-64
- C1 -
-
2VTQ
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
-----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
381
Blastp_CBE
64.04
40%
-48
- C1 -
-
2UZE
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
567
HHSearch
63.93
31%
-20
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[6-306]
-
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
-
R
L
T
G
Q
Q
V
A
I
K
K
I
P
---
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
---
H
D
N
I
I
A
I
K
D
I
--
L
-
R
PTVPYG
E
F
----
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
-----
S
----
S
-
Q
-
P
--
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
--
N
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
-
G
L
-
C
T
S
-
P
AEHQY
F
M
T
-
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
-
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
----
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
-
Q
S
L
P
--
P
R
Q
P
V
-
P
W
E
T
V
-
Y
P
G
A
-
D
R
----
Q
----
A
------------
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
--
A
K
Y
H
D
---
P
---------------------------------------------------------------------------------------
404
Blastp_CBE
63.93
40%
-46
- C1 -
-
3DOG
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
-
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
211
Blastp_CBE
64.00
40%
-61
- C1 -
-
1AQ1
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
---------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
495
Blastp_CBE
63.98
40%
-52
- C1 -
-
1OIU
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
474
Blastp_CBE
63.97
40%
-50
- C1 -
-
1H1S
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
393
Blastp_CBE
63.93
40%
-50
- C1 -
-
1JST
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
493
Blastp_CBE
63.91
40%
-48
- C1 -
-
1OIY
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
453
Blastp_CBE
63.90
40%
-56
- C1 -
-
4EOQ
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
424
Blastp_CBE
63.87
40%
-54
- C1 -
-
2IW9
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
464
Blastp_CBE
63.82
40%
-51
- C1 -
-
5CYI
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
377
Blastp_CBE
63.77
40%
-50
- C1 -
-
4II5
3
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
380
Blastp_CBE
63.73
40%
-50
- C1 -
-
2UZL
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
500
Blastp_CBE
63.57
40%
-50
- C1 -
-
6GUE
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
N
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
475
Blastp_CBE
63.63
40%
-49
- C1 -
-
1H1R
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
478
Blastp_CBE
63.61
40%
-54
- C1 -
-
1H1Q
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
467
Blastp_CBE
63.52
40%
-49
- C1 -
-
4CFX
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
412
Blastp_CBE
63.57
40%
-52
- C1 -
-
2CCI
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
491
Blastp_CBE
63.56
40%
-51
- C1 -
-
4CFN
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
358
Blastp_CBE
63.53
40%
-49
- C1 -
-
2IW8
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
H
V
D
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
132
Blastp_CBE
63.52
40%
-48
- C1 -
-
2FVD
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
------------
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
---
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
379
Blastp_CBE
63.48
40%
-47
- C1 -
-
2UZL
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
171
Blastp_CBE
63.46
40%
-79
- C1 -
-
1PYE
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
456
Blastp_CBE
63.32
40%
-54
- C1 -
-
4BCM
1
CDK2_HUMAN
C:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
106
Blastp_CBE
63.33
40%
-65
- C1 -
-
2VTT
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
181
Blastp_CBE
63.32
40%
-63
- C1 -
-
1P2A
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
----------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
182
Blastp_CBE
63.31
40%
-73
- C1 -
-
1OIQ
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
437
Blastp_CBE
63.24
40%
-49
- C1 -
-
4BCN
1
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
374
Blastp_CBE
63.22
40%
-53
- C1 -
-
4EOR
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
386
Blastp_CBE
63.18
40%
-49
- C1 -
-
2UZB
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
559
HHSearch
63.16
33%
-29
- C1 -
-
4NM3
5
GSK3B_HUMAN
A:
[55-346]
--
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
D
S
G
E
L
V
A
I
K
K
V
L
---
Q
D
K
------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
---
H
C
N
I
V
R
L
R
Y
F
--
F
-
Y
------
S
S
KKDE
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
-----
H
YSR
A
K
-
Q
-
T
--
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
--
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
-
Q
L
-
V
R
G
-
E
-----
P
N
V
-
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
-
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
----
T
P
T
R
E
Q
I
R
E
M
N
--
P
N
Y
T
E
F
-
K
F
P
Q
--
I
K
A
H
P
-
W
T
K
V
F
-
R
P
R
T
-
P
P
----
E
----
A
------------
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
--
D
E
L
R
D
---
P
---------------------------------------------------------------------------------------
487
Blastp_CBE
63.15
40%
-54
- C1 -
-
6GUC
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
421
Blastp_CBE
63.09
40%
-45
- C1 -
-
4I3Z
3
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
362
Blastp_CBE
63.05
40%
-44
- C1 -
-
4EOP
1
CDK2_HUMAN
A:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
415
Blastp_CBE
63.00
40%
-43
- C1 -
-
1QMZ
1
CDK2_HUMAN
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
429
Blastp_CBE
62.98
40%
-47
- C1 -
-
3QHR
2
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
492
Blastp_CBE
62.94
40%
-47
- C1 -
-
1OIY
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
471
Blastp_CBE
62.92
40%
-46
- C1 -
-
4CFM
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
439
Blastp_CBE
62.84
40%
-52
- C1 -
-
4BCK
2
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
383
Blastp_CBE
62.83
40%
-52
- C1 -
-
2UZD
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
490
Blastp_CBE
62.80
40%
-49
- C1 -
-
4CFN
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
34
Blastp_CBE
62.77
40%
-70
- C1 -
-
5FP5
3
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------------
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
428
Blastp_CBE
62.74
40%
-48
- C1 -
-
3QHW
2
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
484
Blastp_CBE
62.73
40%
-47
- C1 -
-
6GUF
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
39
Blastp_CBE
62.71
40%
-69
- C1 -
-
5ANG
1
CDK2_HUMAN
A:
[2-286]
-
E
N
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
407
Blastp_CBE
62.66
40%
-54
- C1 -
-
3DDP
1
CDK2_HUMAN
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
450
Blastp_CBE
62.65
40%
-46
- C1 -
-
4EOS
1
CDK2_HUMAN
C:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
436
Blastp_CBE
62.54
40%
-52
- C1 -
-
4BCN
1
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
400
Blastp_CBE
62.62
40%
-42
- C1 -
-
6GVA
3
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
--
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
427
Blastp_CBE
62.59
40%
-49
- C1 -
-
3QHW
3
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
359
Blastp_CBE
62.54
40%
-54
- C1 -
-
4EOO
1
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
430
Blastp_CBE
62.40
40%
-49
- C1 -
-
3QHR
6
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
425
Blastp_CBE
62.48
40%
-50
- C1 -
-
2IW6
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
466
Blastp_CBE
62.43
40%
-46
- C1 -
-
4CFX
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
486
Blastp_CBE
62.41
40%
-54
- C1 -
-
6GUC
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
416
Blastp_CBE
62.40
40%
-45
- C1 -
-
1QMZ
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
413
Blastp_CBE
62.33
40%
-43
- C1 -
-
2CCH
1
CDK2_HUMAN
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
468
Blastp_CBE
62.27
40%
-52
- C1 -
-
4CFW
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
385
Blastp_CBE
62.18
40%
-46
- C1 -
-
2UZB
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
451
Blastp_CBE
62.17
40%
-48
- C1 -
-
4EOS
1
CDK2_HUMAN
A:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
---
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
480
Blastp_CBE
62.15
40%
-44
- C1 -
-
1H1P
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
560
HHSearch
62.14
31%
-20
- C1 -
-
4ZSG
6
MK07_HUMAN
A:
[7-307]
-
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
-
R
L
T
G
Q
Q
V
A
I
K
K
I
P
---
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
---
H
D
N
I
I
A
I
K
D
I
--
L
-
R
PTVPYG
E
F
----
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
---------
S
S
-
Q
-
P
--
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
--
N
E
-
N
C
E
L
K
I
G
D
F
G
M
A
R
-
G
L
-
C
T
S
-
P
AEHQY
F
M
T
-
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
-
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
----
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
-
Q
S
L
P
--
P
R
Q
P
V
-
P
W
E
T
V
-
Y
P
G
A
-
D
R
----
Q
----
A
------------
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
--
A
K
Y
H
D
---
P
---------------------------------------------------------------------------------------
361
Blastp_CBE
62.12
40%
-45
* C1 *
-
4EOP
1
CDK2_HUMAN
C:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
469
Blastp_CBE
62.10
40%
-49
- C1 -
-
4CFW
1
CDK2_HUMAN
A:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
454
Blastp_CBE
62.05
40%
-50
- C1 -
-
4BCQ
1
CDK2_HUMAN
C:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
414
Blastp_CBE
61.93
40%
-47
- C1 -
-
2CCH
3
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
438
Blastp_CBE
61.87
40%
-57
- C1 -
-
4BCK
1
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
440
Blastp_CBE
61.78
40%
-48
- C1 -
-
3TNW
1
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
420
Blastp_CBE
61.69
40%
-49
- C1 -
-
1GY3
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
455
Blastp_CBE
61.71
40%
-53
- C1 -
-
4BCQ
1
CDK2_HUMAN
A:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
392
Blastp_CBE
61.69
40%
-54
- C1 -
-
1JST
1
CDK2_HUMAN
C:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
35
Blastp_CBE
61.65
40%
-67
- C1 -
-
5D1J
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
-----------------
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
-------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
477
Blastp_CBE
61.61
40%
-52
- C1 -
-
1H1Q
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
485
Blastp_CBE
61.50
40%
-48
- C1 -
-
6GUE
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
-----T
S
M
P
D
YK
P
S
F
P
K
----
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
411
Blastp_CBE
61.51
40%
-53
- C1 -
-
2CCI
1
CDK2_HUMAN
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
419
Blastp_CBE
61.50
40%
-49
- C1 -
-
1GY3
2
CDK2_HUMAN
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
417
Blastp_CBE
61.39
40%
-48
- C1 -
-
1P5E
1
CDK2_HUMAN
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
483
Blastp_CBE
61.38
40%
-46
- C1 -
-
6GUF
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
479
Blastp_CBE
61.31
40%
-44
- C1 -
-
1H1P
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
488
Blastp_CBE
60.59
40%
-60
- C1 -
-
6GUB
1
?
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
------
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
511
Blastp_CBE
59.92
37%
-34
- C1 -
-
2PMI
2
PHO85_YEAST
A:
[19-300]
---------------
A
T
V
Y
K
G
L
N
-
K
T
T
G
V
Y
V
A
L
K
E
-
V
---
K
L
D
S
E
E
G
T
P
S
T
A
I
R
E
I
S
L
M
K
E
L
K
---
H
E
N
I
V
R
L
Y
D
V
--
I
-
H
------
T
E
----
N
K
L
T
L
V
F
E
F
M
D
N
D
L
K
K
Y
M
D
SRTVG
N
---
T
P
-
R
-
G
--
L
E
L
N
L
V
K
Y
F
Q
W
Q
L
L
Q
G
L
A
F
C
H
E
N
K
I
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
K
-
R
G
Q
L
K
L
G
D
F
G
L
A
R
-
A
F
G
I
P
V
-
N
-----
T
F
S
-
S
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
R
T
Y
S
T
S
I
D
I
W
S
C
G
C
I
L
A
E
M
I
-
T
G
K
P
L
F
P
G
T
N
D
E
E
Q
L
K
L
I
F
D
I
M
G
TPNE
S
L
W
P
---
S
V
T
K
L
P
K
Y
N
P
N
I
-
Q
Q
R
P
--
P
R
D
L
R
-
Q
V
L
Q
P
-
H
T
K
--
E
P
----
L
DGN-
L
------------
M
D
F
L
H
G
L
L
Q
L
N
P
D
M
R
L
S
A
K
Q
A
L
H
H
P
W
F
--
A
E
Y
---------------------------------------------------------------------------------------------
64
Blastp_CBE
59.81
40%
-64
- C1 -
-
4D1Z
2
CDK2_HUMAN
A:
[3-286]
--
N
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
-------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
521
Blastp_CBE
59.67
36%
0
- C1 -
-
1XO2
1
CDK6_HUMAN
B:
[11-305]
-
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
---
V
Q
T
G
E
E
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
--
C
-
T
VS----
R
E
----
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
-----
K
---
V
P
-
E
P
G
--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
--
T
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
-
I
Y
-
S
F
Q
-
M
-----
A
L
T
-
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
-
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
LPGE
E
D
W
P
R
D
V
A
L
P
R
Q
A
--
F
H
------------
A
Q
-
P
I
E
K
F
-
V
T
D
I
-
D
E
----
L
----
G
------------
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--
Q
D
L
E
R
-------------------------------------------------------------------------------------------
409
Blastp_CBE
59.58
40%
-58
- C1 -
-
2G9X
1
CDK2_HUMAN
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
--------------------------
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
525
Blastp_CBE
59.47
37%
-27
- C1 -
-
5L2S
1
CDK6_HUMAN
A:
[11-300]
-
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
---
V
-------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
--
C
--------------
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
-----
K
---
V
P
-
E
P
G
--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
--
T
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
V
L
L
-
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
LPGE
E
D
W
P
R
D
V
A
L
P
R
Q
A
--
F
H
S
K
-
S
--------
A
Q
-
P
I
E
K
F
-
V
T
D
I
-
D
E
----
L
----
G
------------
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--------------------------------------------------------------------------------------------------
367
Blastp_CBE
59.34
40%
-56
- C1 -
-
4EOJ
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
------------------
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
501
Blastp_CBE
59.03
38%
-48
- C1 -
-
3O0G
1
CDK5_HUMAN
B:
[6-288]
-----
K
L
E
K
I
-----
G
T
V
F
K
A
-------
E
I
V
A
L
K
R
V
R
-----------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
--
L
-
H
------
S
D
----
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
-----
S
---
C
N
-
G
-
D
--
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
-
A
F
G
I
P
V
-
R
-----
C
Y
S
-
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
------
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
-
P
Y
P
M
--
Y
P
A
T
T
-
S
L
V
N
V
-
V
P
K
L
-
N
A
----
T
----
G
------------
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--
S
D
----------------------------------------------------------------------------------------------
448
Blastp_CBE
58.98
40%
-61
- C1 -
-
3BHT
1
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
----------------------------
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
58.95
40%
-72
- C1 -
-
2R3N
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
403
Blastp_CBE
58.85
40%
-56
- C1 -
-
3DOG
1
CDK2_HUMAN
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
---------------------------------
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
444
Blastp_CBE
58.82
40%
-60
- C1 -
-
3BHV
1
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
----------------------------
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
524
Blastp_CBE
58.60
37%
-26
- C1 -
-
5L2T
1
CDK6_HUMAN
A:
[11-300]
-
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
---
V
---------
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
--
C
--------------
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
-----
K
---
V
P
-
E
P
G
--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
--
T
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
V
L
L
-
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
LPGE
E
D
W
P
R
D
V
A
L
P
R
Q
A
--
F
H
S
K
-
S
--------
A
Q
-
P
I
E
K
F
-
V
T
D
I
-
D
E
----
L
----
G
------------
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--------------------------------------------------------------------------------------------------
446
Blastp_CBE
58.53
40%
-60
- C1 -
-
3BHU
1
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
----------------------------
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
498
Blastp_CBE
58.49
40%
-60
- C1 -
-
1OGU
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
----------------------------
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
460
Blastp_CBE
58.44
40%
-58
- C1 -
-
4CFU
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
----------------------------
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
394
Blastp_CBE
58.27
40%
-40
- C1 -
-
1FQ1
1
CDK2_HUMAN
B:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
452
Blastp_CBE
57.99
40%
-57
- C1 -
-
4EOQ
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
-------------------------
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
434
Blastp_CBE
57.94
40%
-54
- C1 -
-
4BCO
1
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
-----------------------------
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
442
Blastp_CBE
57.88
40%
-64
- C1 -
-
3MY5
1
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
------------------------------------------
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
357
Blastp_CBE
57.86
40%
-56
- C1 -
-
2IW8
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
H
V
D
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------------------------------------
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
505
Blastp_CBE
57.81
38%
-50
- C1 -
-
1UNG
1
CDK5_HUMAN
B:
[2-287]
-
Q
K
Y
E
K
L
E
K
-------
T
V
F
K
A
--------
I
V
A
L
K
R
V
R
---
L
D
----
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
---
H
K
N
I
V
R
L
H
D
V
--
L
-
H
------
S
D
----
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
-----
S
---
C
N
-
G
-
D
--
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
R
-
N
G
E
L
K
L
A
N
F
G
L
A
R
-
A
F
G
I
P
V
-
R
-----
C
Y
S
-
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
------
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
Y
K
-
P
Y
P
M
--
Y
P
A
T
T
-
S
L
V
N
V
-
V
P
K
L
-
N
A
----
T
----
G
------------
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--
S
-----------------------------------------------------------------------------------------------
470
Blastp_CBE
57.59
40%
-56
- C1 -
-
4CFM
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
-------------------------------------
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
423
Blastp_CBE
57.57
40%
-56
- C1 -
-
2IW9
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
-------------------------------
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
405
Blastp_CBE
57.41
40%
-56
- C1 -
-
3DDQ
1
CDK2_HUMAN
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------------------------------------
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
373
Blastp_CBE
57.30
40%
-54
- C1 -
-
4EOR
1
CDK2_HUMAN
C:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
--------------------------
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
529
Blastp_CBE
56.94
37%
-31
- C1 -
-
3NUX
1
CDK6_HUMAN
A:
[11-300]
-
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
-----------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
--
C
--------------
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
-----
K
---
V
P
-
E
P
G
--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
--
T
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
V
L
L
-
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
LPGE
E
D
W
P
R
D
V
A
L
P
R
Q
A
--
F
H
-
K
-
S
--------
A
Q
-
P
I
E
K
F
-
V
T
D
I
-
D
E
----
L
----
G
------------
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--------------------------------------------------------------------------------------------------
527
Blastp_CBE
56.46
37%
-21
- C1 -
-
4EZ5
1
CDK6_HUMAN
A:
[11-300]
-
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
------------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
--
C
--------------
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
-----
K
---
V
P
-
E
P
G
--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
--
T
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
V
L
L
-
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
LPGE
E
D
W
P
R
D
V
A
L
P
R
Q
A
--
F
H
---
S
--------
A
Q
-
P
I
E
K
F
-
V
T
D
I
-
D
E
----
L
----
G
------------
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--------------------------------------------------------------------------------------------------
432
Blastp_CBE
56.38
40%
-56
- C1 -
-
4BCP
1
CDK2_HUMAN
C:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
----------------------------
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
526
Blastp_CBE
56.13
37%
-32
- C1 -
-
5L2I
1
CDK6_HUMAN
A:
[11-300]
-
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
-----------
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
--
C
--------------
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
-----
K
---
V
P
-
E
P
G
--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
--
T
S
-
S
G
Q
I
K
L
A
D
F
G
L
-----------------------
V
T
L
W
Y
R
A
P
E
V
L
L
-
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
LPGE
E
D
W
P
R
D
V
A
L
P
R
Q
A
--
F
--
K
-
S
--------
A
Q
-
P
I
E
K
F
-
V
T
D
I
-
D
E
----
L
----
G
------------
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--------------------------------------------------------------------------------------------------
494
Blastp_CBE
55.87
40%
-55
- C1 -
-
1OIU
1
CDK2_HUMAN
C:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
-------------------------------------------
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
519
Blastp_CBE
55.66
36%
-2
- C1 -
-
2F2C
2
CDK6_HUMAN
B:
[11-305]
-
Q
Q
Y
E
C
-
A
E
I
G
----
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
---
V
Q
T
G
E
E
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
--
C
-
T
VSTD--
R
E
----
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
-----
K
---
V
P
-
E
P
G
--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
--
T
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
-
I
Y
-
S
F
Q
-
M
-----
A
L
T
-
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
-
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
LPGE
E
D
W
P
-------
Q
A
--
F
-------------
A
Q
-
P
I
E
K
F
-
V
T
D
I
-
D
E
----
L
----
G
------------
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--
Q
D
L
E
R
-------------------------------------------------------------------------------------------
458
Blastp_CBE
55.64
40%
-57
- C1 -
-
4CFV
1
CDK2_HUMAN
C:
[6-291]
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
---------------------------------
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
528
Blastp_CBE
55.44
37%
-28
- C1 -
-
4AUA
1
CDK6_HUMAN
A:
[11-300]
-
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
-
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
---------------
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
--
C
--------------
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
-----
K
---
V
P
-
E
P
G
--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
--
T
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
-----------------------
T
L
W
Y
R
A
P
E
V
L
L
-
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
LPGE
E
D
W
P
R
D
V
A
L
P
R
Q
A
--
F
H
S
K
-
S
--------
A
Q
-
P
I
E
K
F
-
V
T
D
I
-
D
E
----
L
----
G
------------
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--------------------------------------------------------------------------------------------------
24
Blastp_CBE
53.98
48%
-95
- C1 -
-
6Q4G
1
CDK2_HUMAN
A:
[9-228]
M
E
N
F
E
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
534
Blastp_CBE
53.36
33%
-14
- C1 -
-
6CKX
1
C:
[12-312]
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
-
K
D
T
G
E
L
V
A
L
K
K
V
R
LDN
E
K
E
G
F
P
I
T
---
A
I
R
E
I
K
I
L
R
Q
L
I
---
H
R
S
V
V
N
M
K
E
I
--
V
T-------
D
K
----
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
-----
S
---
G
L
-
V
-
H
--
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
--
N
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
-
L
Y
-
N
S
E
-
E
-----
S
R
P
Y
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
----
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
-
K
-
P
K
--
K
Q
Y
R
R
-
R
L
R
E
E
-
F
S
F
I
-
P
S
----
A
----
A
------------
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
-----
D
F
L
K
D
---
V
E
L
-------------------------------------------------------------------------------------
535
Blastp_CBE
53.12
33%
-13
- C1 -
-
6CKX
1
CDK12_HUMAN
A:
[12-312]
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
-
K
D
T
G
E
L
V
A
L
K
K
V
R
LDN
E
K
E
G
F
P
I
T
---
A
I
R
E
I
K
I
L
R
Q
L
I
---
H
R
S
V
V
N
M
K
E
I
--
V
T-------
D
K
----
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
-----
S
---
G
L
-
V
-
H
--
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
--
N
N
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
-
L
Y
-
N
S
E
-
E
-----
S
R
P
Y
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
-
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
----
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
-
K
-
P
K
--
K
Q
Y
R
R
-
R
L
R
E
E
-
F
S
F
I
-
P
S
----
A
----
A
------------
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
-----
D
F
L
K
D
---
V
E
L
-------------------------------------------------------------------------------------
522
Blastp_CBE
52.76
36%
-7
- C1 -
-
4TTH
1
CDK6_HUMAN
B:
[15-304]
-----
C
V
A
E
I
G
E
----
K
V
F
K
A
R
D
L
K
N
-
G
R
F
V
A
L
K
R
V
R
---
V
----
E
G
M
P
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
CT---------------
T
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
-----
K
---
V
P
-
E
P
G
--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
--
T
S
-
S
G
Q
I
K
L
A
D
F
G
L
A
R
-
I
Y
-
S
F
Q
-
M
-----
A
L
T
-
S
V
V
V
T
L
W
Y
R
A
P
E
V
L
L
-
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
LPGE
E
D
W
P
----------------------------
P
I
E
K
F
---
D
I
-
D
E
----
L
----
G
------------
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--
Q
D
L
E
--------------------------------------------------------------------------------------------
530
Blastp_CBE
51.84
37%
-11
- C1 -
-
3NUP
1
CDK6_HUMAN
A:
[12-300]
--
Q
Y
E
C
V
A
E
I
G
----
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
-------------
L
S
T
I
R
E
V
A
V
L
R
H
L
E
TFE
H
P
N
V
V
R
L
F
D
V
--
C
-
T
V------------
K
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
-----
K
---
V
P
-
E
P
G
--
V
P
T
E
T
I
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
--
T
S
-
S
G
Q
I
K
L
A
D
F
G
L
-----------------------
V
T
L
W
Y
R
A
P
E
V
L
L
-
Q
S
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
-
R
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
K
I
L
D
V
I
G
LPGE
E
D
W
P
R
D
V
A
L
P
R
Q
A
--
F
H
---
S
--------
A
Q
-
P
I
E
K
F
-
V
T
D
I
-
D
E
----
L
----
G
------------
K
D
L
L
L
K
C
L
T
F
N
P
A
K
R
I
S
A
Y
S
A
L
S
H
P
Y
F
--------------------------------------------------------------------------------------------------
336
Blastp_CBE
50.36
40%
-16
- C1 -
-
4RJ3
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
I
R
L
---
D
T
E
--------
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
366
Blastp_CBE
50.12
48%
-76
- C1 -
-
4EOM
1
CDK2_HUMAN
A:
[5-224]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
--
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
49.84
48%
-63
- C1 -
-
4EON
1
CDK2_HUMAN
A:
[3-222]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
49.77
47%
-67
- C1 -
-
4EOK
1
CDK2_HUMAN
C:
[4-223]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
49.23
48%
-58
- C1 -
-
4EON
1
CDK2_HUMAN
C:
[3-222]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
48.94
48%
-60
- C1 -
-
4EOI
1
CDK2_HUMAN
C:
[2-221]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
D
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
399
Blastp_CBE
48.92
47%
-67
- C1 -
-
1E9H
1
CDK2_HUMAN
A:
[2-221]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
372
Blastp_CBE
48.72
47%
-68
- C1 -
-
4EOK
1
CDK2_HUMAN
A:
[4-223]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
398
Blastp_CBE
48.19
47%
-64
- C1 -
-
1E9H
1
CDK2_HUMAN
C:
[2-221]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
518
Blastp_CBE
47.93
40%
-114
- C1 -
-
3GC0
1
?
A:
[33-255]
I
D
R
Y
R
R
I
T
K
L
G
E
G
T
Y
G
E
V
Y
K
A
I
D
-
T
V
T
N
E
T
V
A
I
K
R
I
R
---
L
E
H
-------
T
A
I
R
E
V
S
L
L
K
E
L
Q
---
H
R
N
I
I
E
L
K
S
V
--
I
-
H
------
H
N
----
H
R
L
H
L
I
F
E
Y
A
E
N
D
L
K
K
Y
M
D
-----
K
---
N
P
-
D
----
V
S
M
R
V
I
K
S
F
L
Y
Q
L
I
N
G
V
N
F
C
H
S
R
R
C
L
H
R
D
L
K
P
Q
N
L
L
L
SV-
E
-
T
P
V
L
K
I
G
D
F
G
L
A
R
-
A
F
----------------
E
I
I
T
L
W
Y
R
P
P
E
I
L
L
G
S
R
H
Y
S
T
S
V
D
I
W
S
I
A
C
I
W
A
E
M
L
-
M
K
T
P
L
F
P
G
D
S
E
I
D
Q
L
F
K
I
F
E
V
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
369
Blastp_CBE
47.85
47%
-60
- C1 -
-
4EOL
1
CDK2_HUMAN
C:
[4-223]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
356
Blastp_CBE
47.85
48%
-61
- C1 -
-
4EOI
2
CDK2_HUMAN
A:
[2-221]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
D
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
47.83
40%
-37
- C1 -
-
1OIR
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
I
R
---------
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
338
Blastp_CBE
47.81
40%
-43
- C1 -
-
1H01
3
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
I
R
---------
G
V
-
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
T
-
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----
T
---------
P
D
E
V
V
W
P
G
V
T
S
M
P
D
YK
P
S
F
P
K
-
W
A
R
Q
D
-
F
S
K
V
-
V
P
----
P
LDED
G
------------
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
--------------------------------------------------------------------------------------------------
397
Blastp_CBE
47.67
47%
-67
- C1 -
-
1PKD
1
CDK2_HUMAN
A:
[2-221]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
47.16
47%
-67
- C1 -
-
1PKD
1
CDK2_HUMAN
C:
[2-221]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
-----
A
---
S
A
L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
370
Blastp_CBE
46.29
47%
-58
- C1 -
-
4EOL
1
CDK2_HUMAN
A:
[4-223]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
L
--
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
---
H
P
N
I
V
K
L
L
D
V
--
I
-
H
------
T
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
-----
A
---
S
-L
T
-
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
--
N
T
-
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
-
R
-----
T
Y
H
-
E
-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
---------------------------------------------------------------------------------