@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDKL5_HUMAN: (2020-09-06 )
MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFFRSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPALQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISSPAPYPVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLTYHENAALTGK
Atome Classification :
(513 SA)
.........10........20........30......-..40........50........60........70------....-----...---------.80-----.------.----.......90........100---..-..--...110.......120.......130.......140.------..-.---.---..150.......160...---.---...170.......180..-.-.-.-..190.......200....-...210.......220......-------.230---..----.--------....--------240.....-.--.250--------..--.-.-.....260........270-.........280.......290.......300...-....310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKIP
N
I
G
N
V
M
N
K
F
E
I
L
G
V
VGEG
A
Y
G
V
V
L
K
C
RHKET
H
E
-
I
V
A
I
KKFKDSEE
N
E
E
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
------
I
V
E
L
-----
K
E
A
---------
F
R
------R------R----G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E---MP-NG--V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
HKNDIVHRDIKPE
N
L
L
I------SH-N---
D
---
V
L
K
L
CDFGFARNLSEGNN---A---
N
Y
T
E
Y
V
A
T
R
WYRSPE
L
L
L
-G-A-P-YGKSVD
M
W
S
V
G
C
I
LGELSD-GQPLFP
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
LG-------PL
P
S
---
E
Q
----
M
--------
K
L
FY--------SNPRFHGL-R--FP----------AV--N-H-
P
Q
S
L
E
R
R
-
Y
L
G
I
L
N
S
V
L
---
L
D
L
M
K
N
L
LKLDPA
D
R
Y
L
T
E
Q
C
LNHPT
F
Q
T
Q
R
L
L
DR-SPSRSAKRK
P
Y
H
VESSTLSNRNQAGKS
T
A
L
Q
S
HHRSNSK
D
I
Q
N
LSVGLPRADEGLPANESFLNGNLAGASLSP
L
H
T
K
T
YQASSQPGSTSKDLTNNNIPHLL
S
P
K
EAKSKT
E
F
D
FNIDPKPSEGPGT
K
Y
LKSNSR
S
Q
Q
N
R
H
S
F
M
E
SSQSKAGTLQPNEK
Q
S
R
H
S
Y
I
DTIPQSSRSPSYRTKAKSHGALSDSKSV
S
N
L
S
E
A
R
A
QIAEPSTSRYF
P
S
S
CLDLNSPTSPTPTRHSDT
R
T
LLSPSGRNNRNEGTLDSRRTTT
R
H
S
K
T
M
E
E
LKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHS
M
Y
V
T
R
D
K
V
RAKGLDGSLSIGQGMAARAN
S
L
Q
LLSPQPGEQLPP
E
M
T
V
A
R
S
S
V
K
E
T
S
REGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPV
P
R
R
VGSFYRVPSPRPDNSFHEN
N
V
S
T
R
V
SSLPSESSSGTNHSKRQPAFDPWKSPENI
S
H
S
E
Q
L
K
E
K
E
K
Q
G
F
F
R
S
M
K
K
K
K
KKSQTVPNSDSP
D
L
L
T
L
Q
K
S
IHSASTPSSRPKEWRP
E
K
I
S
D
L
QT
Q
S
Q
P
L
K
S
L
R
K
L
L
H
LSSASNHPASSDPRFQPL
T
A
Q
Q
TKNSFS
E
I
R
I
H
PLSQASGGSSNIRQEPAPKGRPALQLPDGGCDGRRQRHHSGPQD
R
R
F
M
L
R
TTEQQG
E
Y
F
CCGDPKKPHTPCVPN
R
A
LHRPISSPAPY
P
V
L
Q
VRGTSMC
P
T
L
Q
V
RGTDAFSCPTQQS
G
F
S
F
F
V
R
H
V
M
R
E
A
L
I
H
R
A
QVN
Q
A
A
L
L
T
Y
HENAALTGK
1
PsiBlast_PDB
96.44
99%
-126
- C1 -
-
4BGQ
3
CDKL5_HUMAN
A:
[10-303]
--------
V
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
H
E
-
I
V
A
I
K
K
F
K
-------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
------
I
V
E
L
-----
K
E
A
---------
F
R
------
R
------
R
----
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
---
M
P
-
N
G
--
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
------
S
H
-
N
---
D
---
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
-----------------
T
R
W
Y
R
S
P
E
L
L
L
-
G
-
A
-
P
-
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
-
G
Q
P
L
F
P
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
L
G
-------
P
L
P
S
---
E
Q
----
M
--------
K
L
F
Y
--------
S
N
P
R
F
H
G
L
-
R
--
F
P
----------
A
V
--
N
-
H
-
P
Q
S
L
E
R
R
-
Y
L
G
I
L
N
S
V
L
---
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
539
HHSearch
96.23
99%
-126
- C1 -
-
4BGQ
3
CDKL5_HUMAN
A:
[10-302]
--------
V
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
H
E
-
I
V
A
I
K
K
F
K
-------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
------
I
V
E
L
-----
K
E
A
---------
F
R
------
R
------
R
----
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
---
M
P
-
N
G
--
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
------
S
H
-
N
---
D
---
V
L
K
L
C
D
F
G
F
A
R
N
L
S
E
-----------------
T
R
W
Y
R
S
P
E
L
L
L
-
G
-
A
-
P
-
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
-
G
Q
P
L
F
P
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
L
G
-------
P
L
P
S
---
E
Q
----
M
--------
K
L
F
Y
--------
S
N
P
R
F
H
G
L
-
R
--
F
P
----------
A
V
--
N
-
H
-
P
Q
S
L
E
R
R
-
Y
L
G
I
L
N
S
V
L
---
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
78.38
47%
-96
- C1 -
-
4BBM
3
CDKL2_HUMAN
A:
[24-318]
---------
M
E
K
Y
E
N
L
G
L
V
--
G
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
-
I
V
A
I
K
K
F
L
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
------
L
V
N
L
-----
L
E
V
---------
C
K
------
K
------
K
----
K
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
L
---
F
P
-
N
G
--
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
------
S
Q
-
S
---
G
---
V
V
K
L
C
D
F
G
F
A
R
T
L
A
A
P
G
E
---
V
----
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
-
G
D
V
-
K
-
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
-
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
-------
N
L
I
P
---
R
H
----
Q
--------
E
L
F
N
--------
K
N
P
V
F
A
G
V
-
R
--
L
P
----------
E
I
--
K
-
E
-
R
E
P
L
E
R
R
-
Y
P
K
-
L
S
E
V
V
---
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
77.24
47%
-102
- C1 -
-
4AAA
7
CDKL2_HUMAN
A:
[24-318]
---------
M
E
K
Y
E
N
L
G
L
V
G
E
G
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
-
I
V
A
I
K
K
F
L
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
------
L
V
N
L
-----
L
E
V
---------
C
K
------
K
------
K
----
K
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
L
---
F
P
-
N
G
--
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
------
S
Q
-
S
---
G
---
V
V
K
L
C
D
F
G
F
A
-------------------
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
-
G
D
V
-
K
-
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
-
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
-------
N
L
I
P
---
R
H
----
Q
--------
E
L
F
N
--------
K
N
P
V
F
A
G
V
-
R
--
L
P
----------
E
I
--
K
-
E
-
R
E
P
L
E
R
R
-
Y
P
K
-
L
S
E
V
V
---
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
75.12
48%
-100
- C1 -
-
4BBM
3
CDKL2_HUMAN
B:
[24-318]
---------
M
E
K
Y
E
N
L
-----
G
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
-
I
V
A
I
K
K
F
---------
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
------
L
V
N
L
-----
L
E
V
---------
C
----------------------
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
L
---
F
P
-
N
G
--
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
------
S
Q
-
S
---
G
---
V
V
K
L
C
D
F
G
F
A
R
T
L
A
A
P
G
E
---
V
----
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
-
G
D
V
-
K
-
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
-
G
E
P
L
F
P
G
D
S
D
I
D
Q
L
Y
H
I
M
M
C
L
G
-------
N
L
I
P
---
R
H
----
Q
--------
E
L
F
N
--------
K
N
P
V
F
A
G
V
-
R
--
L
P
----------
E
I
--
K
-
E
-
R
E
P
L
E
R
R
-
Y
P
K
-
L
S
E
V
V
---
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
74.44
46%
-77
- C1 -
-
4AGU
1
CDKL1_HUMAN
C:
[3-292]
----------
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
-
I
V
A
I
K
K
F
L
E
S
E
D
D
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
------
L
V
N
L
-----
L
E
V
---------
F
R
------
R
------
K
----
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
R
---
Y
Q
-
R
G
--
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
------
T
K
-
H
---
S
---
V
I
K
L
C
D
F
G
F
A
R
L
L
-------------------
T
R
W
Y
R
S
P
E
L
L
V
-
G
D
T
-
Q
-
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
-
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
-------
D
L
I
P
---
R
H
----
Q
--------
Q
V
F
S
--------
T
N
Q
Y
F
S
G
V
-
K
--
I
P
----------
D
P
--
E
-
D
-
M
E
P
L
E
L
K
-
F
P
N
I
-
S
Y
P
A
---
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
74.38
46%
-83
- C1 -
-
4AGU
1
CDKL1_HUMAN
B:
[4-293]
-----------
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
-
I
V
A
I
K
K
F
L
E
S
--
D
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
------
L
V
N
L
-----
L
E
V
---------
F
R
------
R
------
K
----
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
R
---
Y
Q
-
R
G
--
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
------
T
K
-
H
---
S
---
V
I
K
L
C
D
F
G
F
A
R
L
L
-------------------
T
R
W
Y
R
S
P
E
L
L
V
-
G
D
T
-
Q
-
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
-
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
-------
D
L
I
P
---
R
H
----
Q
--------
Q
V
F
S
--------
T
N
Q
Y
F
S
G
V
-
K
--
I
P
----------
D
P
--
E
-
D
-
M
E
P
L
E
L
K
-
F
P
N
I
-
S
Y
P
A
---
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
74.24
46%
-80
- C1 -
-
4AGU
1
CDKL1_HUMAN
A:
[3-292]
----------
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
-
I
V
A
I
K
K
F
L
E
S
E
-
D
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
------
L
V
N
L
-----
L
E
V
---------
F
R
------
R
------
K
----
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
R
---
Y
Q
-
R
G
--
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
------
T
K
-
H
---
S
---
V
I
K
L
C
D
F
G
F
A
R
L
L
-------------------
T
R
W
Y
R
S
P
E
L
L
V
-
G
D
T
-
Q
-
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
-
G
V
P
L
W
P
G
K
S
D
V
D
Q
L
Y
L
I
R
K
T
L
G
-------
D
L
I
P
---
R
H
----
Q
--------
Q
V
F
S
--------
T
N
Q
Y
F
S
G
V
-
K
--
I
P
----------
D
P
--
E
-
D
-
M
E
P
L
E
L
K
-
F
P
N
I
-
S
Y
P
A
---
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
74.14
40%
-72
- C1 -
-
3ZDU
3
CDKL3_HUMAN
A:
[2-303]
---------
M
E
M
Y
E
T
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
K
N
T
G
Q
-
I
V
A
I
K
I
F
Y
--------
N
K
I
A
M
R
E
I
K
F
L
K
Q
F
H
H
E
N
------
L
V
N
L
-----
I
E
V
---------
F
R
------
Q
------
K
----
K
K
I
H
L
V
F
E
F
I
D
H
T
V
L
D
E
L
Q
H
---
Y
C
-
H
G
--
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
------
S
Q
-
S
---
G
---
I
T
K
L
C
D
F
G
F
A
R
T
-----
D
---
I
----
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
V
L
K
D
-
T
-
S
-
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
T
-
G
N
P
Y
L
P
S
S
S
D
L
D
L
L
H
K
I
V
L
K
V
G
-------
N
L
S
P
---
H
L
----
Q
--------
N
I
F
S
--------
K
S
P
I
F
A
G
V
-
V
--
L
P
----------
Q
V
--
Q
-
H
-
P
K
N
A
R
K
K
-
Y
P
K
-
L
N
G
L
L
---
A
D
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
T
R
D
G
F
I
E
K
F
M
P
E
L
K
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
71.58
40%
-59
- C1 -
-
1UNL
1
CDK5_HUMAN
A:
[1-286]
---------
M
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
-
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
------
I
V
R
L
-----
H
D
V
---------
L
H
------
S
------
D
----
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
N
-
G
D
--
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
R
-
N
---
G
---
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
---
C
----
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
-
G
-
A
-
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
-------
T
P
T
E
---
E
Q
----
W
--------
P
S
M
T
--------
K
L
P
D
Y
K
P
Y
P
M
--
Y
P
----------
A
T
--
T
-
S
-
L
V
N
V
V
P
K
-----
L
N
A
T
G
---
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
71.32
40%
-58
- C1 -
-
4AU8
2
CDK5_HUMAN
B:
[7-290]
-----------
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
-
I
V
A
L
K
R
V
R
L
----
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
------
I
V
R
L
-----
H
D
V
---------
L
H
------
S
-----------
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
N
-
G
D
--
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
R
-
N
---
G
---
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
-------------
V
V
T
L
W
Y
R
P
P
D
V
L
F
-
G
-
A
-
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
-------
T
P
T
E
---
E
Q
----
W
--------
P
S
M
T
--------
K
L
P
D
Y
K
P
Y
P
M
--
Y
P
----------
A
T
--
T
-
S
-
L
V
N
V
V
P
K
-----
L
N
A
T
G
---
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
70.26
40%
-60
- C1 -
-
3O0G
-
CDK5_HUMAN
A:
[1-286]
---------
M
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
-
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
------
I
V
R
L
-----
H
D
V
---------
L
H
------
S
------
D
----
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
N
-
G
D
--
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
R
-
N
---
G
---
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
---
C
----
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
-
G
-
A
-
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
-------
T
P
T
E
---
E
Q
----
W
--------
P
S
M
T
--------
K
L
P
D
Y
K
P
Y
P
M
--
Y
P
----------
A
T
--
T
-
S
-
L
V
N
V
V
P
K
-----
L
N
A
T
G
---
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
526
Blastp_CBE
70.25
38%
-81
- C1 -
-
3GC0
1
?
A:
[33-322]
---------
I
D
R
Y
R
R
I
T
K
L
G
E
G
T
Y
G
E
V
Y
K
A
I
D
T
V
T
N
E
-
T
V
A
I
K
R
I
R
L
E
H
-------
T
A
I
R
E
V
S
L
L
K
E
L
Q
H
R
N
------
I
I
E
L
-----
K
S
V
---------
I
H
------
H
------
N
----
H
R
L
H
L
I
F
E
Y
A
E
N
D
L
K
K
Y
M
D
K
---
N
P
-
D
---
V
S
M
R
V
I
K
S
F
L
Y
Q
L
I
N
G
V
N
F
C
H
S
R
R
C
L
H
R
D
L
K
P
Q
N
L
L
L
------
S
V
------ETP
V
L
K
I
G
D
F
G
L
A
R
A
F
----------------
E
I
I
T
L
W
Y
R
P
P
E
I
L
L
-
G
-
S
-
R
H
Y
S
T
S
V
D
I
W
S
I
A
C
I
W
A
E
M
L
M
-
K
T
P
L
F
P
G
D
S
E
I
D
Q
L
F
K
I
F
E
V
L
G
--------
L
P
D
---
D
T
----
T
WPGVTALP
D
W
K
Q
--------
S
F
P
K
F
R
G
--------------------------
K
T
L
K
R
V
-
L
G
A
L
L
D
D
E
G
---
L
D
L
L
T
A
M
L
E
M
D
P
V
K
R
I
S
A
K
N
A
L
E
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
370
Blastp_CBE
70.18
38%
-81
- C1 -
-
1V0P
1
CDC2H_PLAFK
A:
[1-285]
---------
M
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
Y
G
-
E
-
T
F
A
L
K
K
I
R
L
E
K
E
D
E
G
I
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
------
I
V
K
L
-----
Y
D
V
---------
I
H
------
T
------
K
----
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
E
-
G
G
--
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
R
-
E
---
G
---
E
L
K
I
A
D
F
G
L
A
R
A
F
G
----------------
I
V
T
L
W
Y
R
A
P
D
V
L
M
-
G
-
S
K
K
-
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
-------
T
P
N
S
---
K
N
WPNV
T
--------
E
L
P
K
--------
Y
D
P
N
F
-------------------
T
V
--
Y
-
E
-
P
L
P
W
E
-
S
-
F
L
K
G
L
D
E
S
G
---
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
69.46
40%
-59
- C1 -
-
4AU8
2
CDK5_HUMAN
A:
[7-290]
-----------
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
-
I
V
A
L
K
R
---------
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
------
I
V
R
L
-----
H
D
V
---------
L
H
-------------------
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
N
-
G
D
--
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
R
-
N
---
G
---
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
---------
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
-
G
-
A
-
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
-------
T
P
T
E
---
E
Q
----
W
--------
P
S
M
T
--------
K
L
P
D
Y
K
P
Y
P
M
--
Y
P
----------
A
T
--
T
-
S
-
L
V
N
V
V
P
K
-----
L
N
A
T
G
---
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
69.17
40%
-65
- C1 -
-
1UNG
1
CDK5_HUMAN
A:
[1-286]
---------
M
Q
K
Y
E
K
L
E
K
I
----
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
-
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
------
I
V
R
L
-----
H
D
V
---------
L
H
------
S
------
D
----
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
N
-
G
D
--
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
R
-
N
---
G
---
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
---
C
----
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
-
G
-
A
-
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
-------
T
P
T
E
---
E
Q
----
W
--------
P
S
M
T
--------
K
L
P
D
Y
K
P
Y
P
M
--
Y
P
----------
A
T
--
T
-
S
-
L
V
N
V
V
P
K
-----
L
N
A
T
G
---
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
69.15
40%
-63
- C1 -
-
1H4L
-
CDK5_HUMAN
A:
[2-286]
----------
Q
K
Y
E
K
L
E
K
I
----
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
-
I
V
A
L
K
R
V
R
L
D
----
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
------
I
V
R
L
-----
H
D
V
---------
L
H
------
S
------
D
----
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
N
-
G
D
--
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
R
-
N
---
G
---
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
---
C
----
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
-
G
-
A
-
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
A
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
-------
T
P
T
E
---
E
Q
----
W
--------
P
S
M
T
--------
K
L
P
D
Y
K
P
Y
P
M
--
Y
P
----------
A
T
--
T
-
S
-
L
V
N
V
V
P
K
-----
L
N
A
T
G
---
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
68.86
38%
-71
- C1 -
-
1V0O
1
CDC2H_PLAFK
A:
[3-285]
-----------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
Y
G
-
E
-
T
F
A
L
K
K
I
R
L
--------
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
------
I
V
K
L
-----
Y
D
V
---------
I
H
------
T
------
K
----
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
E
-
G
G
--
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
R
-
E
---
G
---
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
-------
K
Y
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
-
G
-
S
K
K
-
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
-------
T
P
N
S
---
K
N
WPNV
T
--------
E
L
P
K
--------
Y
D
P
N
F
-------------------
T
V
--
Y
-
E
-
P
L
P
W
E
-
S
-
F
L
K
G
L
D
E
S
G
---
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
68.56
40%
-68
- C1 -
-
1UNH
-
CDK5_HUMAN
A:
[2-286]
----------
Q
K
Y
E
K
L
E
K
I
----
Y
G
T
V
F
K
A
K
N
R
--
H
E
-
I
V
A
L
K
R
V
R
L
D
----
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
------
I
V
R
L
-----
H
D
V
---------
L
H
------
S
------
D
----
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
N
-
G
D
--
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
R
-
N
---
G
---
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
---
C
----
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
-
G
-
A
-
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
-------
T
P
T
E
---
E
Q
----
W
--------
P
S
M
T
--------
K
L
P
D
Y
K
P
Y
P
M
--
Y
P
----------
A
T
--
T
-
S
-
L
V
N
V
V
P
K
-----
L
N
A
T
G
---
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
538
Blastp_CBE
68.32
36%
-79
- C1 -
-
5G6V
3
CDK16_HUMAN
B:
[1-285]
---------
M
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
K
L
T
D
N
-
L
V
A
L
K
E
I
R
-
L
E
H
E
E
G
A
P
C
T
A
I
R
E
V
S
L
L
K
D
L
K
H
A
N
------
I
V
T
L
-----
H
D
I
---------
I
H
------
T
------
E
----
K
S
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
G
-
N
I
--
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
E
-
R
---
G
---
E
L
K
L
A
D
F
G
L
A
R
A
-------------------
V
T
L
W
Y
R
P
P
D
I
L
L
-
G
-
S
-
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
-
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
-------
T
P
T
E
---
E
T
----
W
--------
P
G
I
L
--------
S
N
E
E
F
K
T
Y
-
N
--
Y
P
----------
K
Y
--
R
-
A
-
E
A
L
L
S
---
H
A
P
R
L
D
S
D
G
---
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
67.16
38%
-80
- C1 -
-
3NIZ
1
?
A:
[18-305]
-------
G
L
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
S
Q
G
-
R
-
I
V
A
L
K
R
I
R
------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
H
P
N
------
I
V
S
L
-----
I
D
V
---------
I
H
------
S
------
E
----
R
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
E
---
N
K
-
T
G
--
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
S
-
D
---
G
---
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----------
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
-
G
-
S
K
K
-
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
-
G
K
P
L
F
P
G
V
T
D
D
D
Q
L
P
K
I
F
S
I
L
G
T------
P
N
P
R
---
E
W
---------------------------
P
Q
V
Q
E
L
-
P
--
L
W
----------
K
Q
--
R
-
T
-
F
Q
V
F
E
K
K
P
W
S
S
I
I
P
G
F
C
QEG
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
66.74
38%
-42
- C1 -
-
3RM7
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
209
Blastp_CBE
66.74
38%
-40
- C1 -
-
1PXI
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
66.63
38%
-36
- C1 -
-
3QZH
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
66.38
38%
-37
- C1 -
-
3R83
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
66.32
38%
-32
- C1 -
-
3RPV
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Blastp_CBE
66.20
39%
-50
- C1 -
-
6Q4F
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
K
-
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
534
Blastp_CBE
66.13
34%
-47
- C1 -
-
2B9H
1
FUS3_YEAST
A:
[6-311]
-----
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
P
T
G
E
-
I
V
A
I
K
K
I
E
P
F
D
K
-
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
------
I
I
T
I
FNIQR
P
D
S
---------
F
E
------
N
------
F
----
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
------
Q
M
--
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
------
N
S
-
N
---
C
---
D
L
K
V
C
D
F
G
L
A
R
I
I
D
-------------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
-
A
-
K
-
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
-
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
-------
T
P
H
S
---
D
N
----
D
--------
L
R
C
I
--------
E
S
P
R
A
R
E
Y
-
I
--
K
S
----------
L
P
--
M
-
Y
-
P
A
A
P
L
E
K
-
M
F
P
R
V
N
P
K
G
---
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
301
Blastp_CBE
66.12
38%
-37
- C1 -
-
3R28
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
280
Blastp_CBE
66.10
38%
-42
- C1 -
-
3RAI
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
66.00
38%
-36
- C1 -
-
3RPO
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
65.96
38%
-38
- C1 -
-
3QQF
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
65.87
38%
-66
- C1 -
-
1V0O
1
CDC2H_PLAFK
B:
[3-285]
-----------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
Y
G
-
E
-
T
F
A
L
K
K
I
R
L
----------
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
------
I
V
K
L
-----
Y
D
V
---------
I
H
------
T
------
K
----
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
E
-
G
G
--
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
R
-
E
---
G
---
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
-------
K
Y
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
-
G
-
S
K
K
-
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
-------
T
P
N
S
---
K
N
WPNV
T
--------
E
L
P
K
--------
Y
D
P
N
F
-------------------
T
V
--
Y
-
E
-
P
L
P
W
E
-
S
-
F
L
K
G
L
D
E
S
G
---
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
65.84
38%
-40
- C1 -
-
3R73
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
65.82
38%
-41
- C1 -
-
3R1Y
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
65.73
38%
-39
- C1 -
-
3R9H
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
65.72
40%
-69
- C1 -
-
3O0G
1
CDK5_HUMAN
B:
[6-286]
--------------
K
L
E
K
I
-----
G
T
V
F
K
A
------
E
-
I
V
A
L
K
R
V
R
--------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
------
I
V
R
L
-----
H
D
V
---------
L
H
------
S
------
D
----
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
N
-
G
D
--
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
R
-
N
---
G
---
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
---
C
----
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
-
G
-
A
-
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
-------
T
P
T
E
---
E
Q
----
W
--------
P
S
M
T
--------
K
L
P
D
Y
K
P
Y
P
M
--
Y
P
----------
A
T
--
T
-
S
-
L
V
N
V
V
P
K
-----
L
N
A
T
G
---
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
335
Blastp_CBE
65.71
38%
-36
- C1 -
-
3PXY
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
Blastp_CBE
65.67
38%
-34
- C1 -
-
3TIZ
9
CDK2_HUMAN
A:
[2-287]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
322
Blastp_CBE
65.65
38%
-34
- C1 -
-
3QTQ
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
65.57
38%
-34
- C1 -
-
3QQK
6
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
65.62
35%
-42
- C1 -
-
2B9F
1
FUS3_YEAST
A:
[6-311]
-----
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
P
T
G
E
-
I
V
A
I
K
K
I
E
P
F
D
K
-
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
------
I
I
T
I
FNIQR
P
D
S
---------
F
E
------
N
------
F
----
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
------
Q
M
--
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
------
N
S
-
N
---
C
---
D
L
K
V
C
D
F
G
L
A
R
I
I
D
-------------
T
E
Y
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
-
A
-
K
-
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
-
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
-------
T
P
H
S
---
D
N
----
D
--------
L
R
C
I
--------
E
S
P
R
A
R
E
Y
-
I
--
K
S
----------
L
P
--
M
-
Y
-
P
A
A
P
L
E
K
-
M
F
P
R
V
N
P
K
G
---
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
65.57
38%
-33
- C1 -
-
6Q4B
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
65.54
38%
-40
- C1 -
-
3R7E
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
65.47
38%
-33
- C1 -
-
6Q4H
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
299
Blastp_CBE
65.45
38%
-35
- C1 -
-
3R71
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
65.39
38%
-32
- C1 -
-
4FKU
3
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
65.34
38%
-38
- C1 -
-
4EZ3
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
170
Blastp_CBE
65.31
38%
-41
- C1 -
-
2C6I
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
65.30
38%
-34
- C1 -
-
2A0C
1
CDK2_HUMAN
X:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
65.26
38%
-39
- C1 -
-
3R8U
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
65.19
38%
-33
- C1 -
-
3QQG
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
300
Blastp_CBE
65.19
38%
-39
- C1 -
-
3R6X
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
65.22
38%
-32
- C1 -
-
5ANE
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
65.15
38%
-39
- C1 -
-
3R1Q
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
268
Blastp_CBE
65.19
38%
-36
- C1 -
-
3ROY
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
369
Blastp_CBE
65.18
38%
-81
- C1 -
-
1V0P
1
CDC2H_PLAFK
B:
[2-285]
----------
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
Y
G
-
E
-
T
F
A
L
K
-----------
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
------
I
V
K
L
-----
Y
D
V
---------
I
H
------
T
-------------
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
---
C
E
-
G
G
--
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
R
-
E
---
G
---
E
L
K
I
A
D
F
G
L
A
R
A
F
--------------------
L
W
Y
R
A
P
D
V
L
M
-
G
-
S
K
K
-
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
-
G
T
P
L
F
P
G
V
S
E
A
D
Q
L
M
R
I
F
R
I
L
G
-------
T
P
N
S
---
K
N
WPNV
T
--------
E
L
P
K
--------
Y
D
P
N
F
-------------------
T
V
--
Y
-
E
-
P
L
P
W
E
-
S
-
F
L
K
G
L
D
E
S
G
---
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
65.16
34%
-46
- C1 -
-
2B9J
1
FUS3_YEAST
A:
[6-311]
-----
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
P
T
G
E
-
I
V
A
I
K
K
I
E
P
F
D
K
-
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
------
I
I
T
I
FNIQR
P
D
S
---------
F
E
------
N
------
F
----
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
------
Q
M
--
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
------
N
S
-
N
---
C
---
D
L
K
V
C
D
F
G
L
A
R
I
I
D
-------------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
-
A
-
K
-
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
-
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
-------
T
P
H
S
---
D
N
----
D
--------
L
R
C
I
--------
E
S
P
R
A
R
E
Y
-
I
--
K
S
----------
L
P
--
M
-
Y
-
P
A
A
P
L
E
K
-
M
F
P
R
V
N
P
K
G
---
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
65.15
39%
-56
- C1 -
-
6Q3C
1
CDK2_HUMAN
A:
[10-295]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
K
-
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
65.14
38%
-38
- C1 -
-
3QX2
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
65.07
38%
-32
- C1 -
-
3QXO
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
65.12
38%
-41
- C1 -
-
1WCC
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
269
Blastp_CBE
65.07
38%
-32
- C1 -
-
3RNI
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
285
Blastp_CBE
65.01
38%
-34
- C1 -
-
3R9D
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
305
Blastp_CBE
65.03
38%
-38
- C1 -
-
3QZI
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
202
Blastp_CBE
65.02
38%
-34
- C1 -
-
1PXP
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
208
Blastp_CBE
65.01
38%
-37
- C1 -
-
1PXJ
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
203
Blastp_CBE
65.00
38%
-35
- C1 -
-
1PXO
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
64.97
38%
-38
- C1 -
-
2C6O
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
169
Blastp_CBE
64.96
38%
-39
- C1 -
-
2C6K
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
64.88
38%
-34
- C1 -
-
3QL8
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
64.93
38%
-37
- C1 -
-
3S00
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
64.91
38%
-35
- C1 -
-
3R1S
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
220
Blastp_CBE
64.90
38%
-34
- C1 -
-
1HCK
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
64.88
38%
-31
- C1 -
-
3QU0
5
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
64.86
38%
-30
- C1 -
-
2EXM
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
64.84
38%
-34
- C1 -
-
3TI1
8
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
206
Blastp_CBE
64.77
38%
-40
- C1 -
-
1PXL
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
64.76
38%
-34
- C1 -
-
2B53
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
64.74
38%
-39
- C1 -
-
1B39
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
64.72
38%
-38
- C1 -
-
3QZG
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
167
Blastp_CBE
64.71
38%
-37
- C1 -
-
2C6M
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
64.70
38%
-36
- C1 -
-
3R8V
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
64.63
38%
-38
- C1 -
-
3QQJ
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
64.56
38%
-33
- C1 -
-
3QXP
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
274
Blastp_CBE
64.56
38%
-32
- C1 -
-
3RK9
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
64.59
38%
-37
- C1 -
-
3PJ8
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
---
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
219
Blastp_CBE
64.56
38%
-34
- C1 -
-
1JSV
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Blastp_CBE
64.56
38%
-37
- C1 -
-
3UNJ
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
64.51
38%
-34
- C1 -
-
6Q4C
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
533
Blastp_CBE
64.48
34%
-36
- C1 -
-
2B9I
1
FUS3_YEAST
A:
[6-311]
-----
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
H
K
P
T
G
E
-
I
V
A
I
K
K
I
E
P
F
D
K
-
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
------
I
I
T
I
FNIQR
P
D
S
---------
F
E
------
N
------
F
----
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
S
T
------
Q
M
--
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
------
N
S
-
N
---
C
---
D
L
K
V
C
D
F
G
L
A
R
I
I
D
E
------------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
-
A
-
K
-
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
-
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
L
I
F
G
I
I
G
-------
T
P
H
S
---
D
N
----
D
--------
L
R
C
I
--------
E
S
P
R
A
R
E
Y
-
I
--
K
S
----------
L
P
--
M
-
Y
-
P
A
A
P
L
E
K
-
M
F
P
R
V
N
P
K
G
---
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
64.38
38%
-34
- C1 -
-
3PY0
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
194
Blastp_CBE
64.38
38%
-40
- C1 -
-
1Y8Y
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
64.28
38%
-26
- C1 -
-
3QRT
3
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
64.28
38%
-35
- C1 -
-
3TIY
12
CDK2_HUMAN
A:
[2-287]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
64.27
38%
-34
- C1 -
-
3QQH
4
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
275
Blastp_CBE
64.24
38%
-34
- C1 -
-
3RK7
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
64.21
38%
-35
- C1 -
-
4EK4
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
64.20
38%
-35
- C1 -
-
3R7V
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
64.14
38%
-33
- C1 -
-
3QTW
6
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
64.19
38%
-33
- C1 -
-
4KD1
2
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
64.18
38%
-36
- C1 -
-
4EK5
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
64.16
38%
-36
- C1 -
-
2VTM
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
64.14
38%
-35
- C1 -
-
3QZF
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
172
Blastp_CBE
64.11
38%
-33
- C1 -
-
2C68
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
64.10
38%
-32
- C1 -
-
6Q4K
3
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
291
Blastp_CBE
64.09
38%
-35
- C1 -
-
3R8L
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
314
Blastp_CBE
64.01
38%
-32
- C1 -
-
3QWJ
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
64.00
38%
-38
- C1 -
-
2C69
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
63.96
38%
-34
- C1 -
-
3R7Y
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
168
Blastp_CBE
63.93
38%
-34
- C1 -
-
2C6L
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
63.95
38%
-30
- C1 -
-
2XNB
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
--
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
63.89
38%
-34
- C1 -
-
3QTZ
3
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
63.94
38%
-45
- C1 -
-
1KE9
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
63.93
38%
-34
- C1 -
-
2CLX
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
63.86
38%
-35
- C1 -
-
3QX4
3
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
240
Blastp_CBE
63.88
38%
-37
- C1 -
-
1B38
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
317
Blastp_CBE
63.91
38%
-35
- C1 -
-
3QTX
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
63.88
38%
-34
- C1 -
-
2XMY
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
---
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
63.86
38%
-42
- C1 -
-
1W0X
1
CDK2_HUMAN
C:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
63.88
38%
-40
- C1 -
-
4FKL
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
63.81
38%
-28
- C1 -
-
3QQL
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
63.86
38%
-30
- C1 -
-
3LFN
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
----------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
277
Blastp_CBE
63.85
38%
-32
- C1 -
-
3RJC
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
63.83
38%
-46
- C1 -
-
2VTI
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
63.83
38%
-33
- C1 -
-
3EJ1
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
63.81
38%
-27
- C1 -
-
2X1N
1
CDK2_HUMAN
C:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
63.78
38%
-37
- C1 -
-
2VTL
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
351
Blastp_CBE
63.72
38%
-37
- C1 -
-
2BKZ
1
CDK2_HUMAN
C:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVW
P
G
V
T
---
S
M
----
P
--------
D
Y
K
P
--------
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
63.70
38%
-39
- C1 -
-
2VTO
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
63.64
38%
-31
- C1 -
-
1PXN
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
63.63
38%
-37
- C1 -
-
3RKB
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
63.59
38%
-36
- C1 -
-
2R3F
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
63.59
38%
-32
- C1 -
-
2W1H
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
63.59
38%
-40
- C1 -
-
5IEV
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
63.57
38%
-38
- C1 -
-
2C5Y
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
63.56
38%
-35
- C1 -
-
2VTR
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
63.54
38%
-33
- C1 -
-
6Q4D
6
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
---
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
207
Blastp_CBE
63.53
38%
-40
- C1 -
-
1PXK
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
63.52
38%
-32
- C1 -
-
3R8P
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
63.51
38%
-32
- C1 -
-
3QWK
5
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
354
Blastp_CBE
63.50
38%
-33
- C1 -
-
1VYW
1
CDK2_HUMAN
A:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVW
P
G
V
T
---
S
M
----
P
--------
D
Y
K
P
--------
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
63.42
38%
-33
- C1 -
-
6Q4I
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
L
---
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
63.44
38%
-30
- C1 -
-
6Q4A
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
-
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
63.47
38%
-39
- C1 -
-
5IEX
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
63.46
38%
-38
- C1 -
-
2UZO
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
63.42
38%
-35
- C1 -
-
2B54
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
Blastp_CBE
63.44
38%
-33
- C1 -
-
3UNK
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
---
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
155
Blastp_CBE
63.42
38%
-41
- C1 -
-
2R3R
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Blastp_CBE
63.42
38%
-38
- C1 -
-
5IEY
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
63.42
39%
-39
- C1 -
-
6Q4G
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
E
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Blastp_CBE
63.40
38%
-27
- C1 -
-
3LFQ
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
63.40
38%
-28
- C1 -
-
3LFS
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
63.39
38%
-29
- C1 -
-
2C5N
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
323
Blastp_CBE
63.38
38%
-25
- C1 -
-
3QRU
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
63.36
38%
-44
- C1 -
-
1KE7
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
63.35
38%
-48
- C1 -
-
1CKP
2
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Blastp_CBE
63.31
38%
-41
- C1 -
-
3IGG
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
63.30
38%
-27
- C1 -
-
2WEV
1
CDK2_HUMAN
C:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
349
Blastp_CBE
63.22
38%
-31
- C1 -
-
2BPM
1
CDK2_HUMAN
C:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVW
P
G
V
T
---
S
M
----
P
--------
D
Y
K
P
--------
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
276
Blastp_CBE
63.24
38%
-31
- C1 -
-
3RK5
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
156
Blastp_CBE
63.22
38%
-37
- C1 -
-
2R3H
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
281
Blastp_CBE
63.19
38%
-43
- C1 -
-
3RAH
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
63.23
38%
-29
- C1 -
-
4FKO
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
63.22
38%
-31
- C1 -
-
3EJ1
1
CDK2_HUMAN
C:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
63.20
38%
-44
- C1 -
-
5AND
1
CDK2_HUMAN
A:
[2-287]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
224
Blastp_CBE
63.19
38%
-32
- C1 -
-
1H07
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
----
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
350
Blastp_CBE
63.18
38%
-31
- C1 -
-
2BPM
1
CDK2_HUMAN
A:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVW
P
G
V
T
---
S
M
----
P
--------
D
Y
K
P
--------
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
63.17
38%
-48
- C1 -
-
1KE5
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
547
HHSearch
63.14
36%
-7
- C1 -
-
4NM3
5
GSK3B_HUMAN
A:
[54-345]
----------
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
-
L
V
A
I
K
K
V
L
Q
D
K
------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
------
I
V
R
L
-----
R
Y
F
---------
F
Y
------
S
------
S
KKDE
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
YSR
A
K
-
Q
T
--
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------
D
P
D
T
---
A
---
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
--------
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
-
G
-
A
T
D
-
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
-------
T
P
T
R
---
E
Q
----
I
--------
R
E
M
N
--------
P
--
N
Y
T
E
F
-
K
--
F
P
----------
Q
I
--
K
-
A
--
H
P
W
T
K
V
-
F
R
P
R
T
P
P
E
A
---
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
237
Blastp_CBE
63.09
38%
-40
- C1 -
-
1DI8
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
63.09
38%
-34
- C1 -
-
2V0D
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
63.07
38%
-41
- C1 -
-
4FKW
2
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
63.07
41%
-19
- C1 -
-
6GU3
1
CDK1_HUMAN
A:
[15-292]
------------------
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
-
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
------
I
V
S
L
-----
Q
D
V
---------
L
M
------
Q
------
D
----
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
P
-
P
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
D
D
-
K
---
G
---
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
---
V
----
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
-
G
S
A
-
R
-
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
-------
T
-
P
N
---
N
E
----
V
--------
W
P
E
V
--------
E
S
L
Q
D
Y
K
N
-
T
--
F
P
----------
K
W
--
K
---
P
G
S
L
A
-
S
-
H
V
K
N
L
D
E
N
G
---
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
63.06
38%
-35
- C1 -
-
2BKZ
1
CDK2_HUMAN
A:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVW
P
G
V
T
---
S
M
----
P
--------
D
Y
K
P
--------
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
342
Blastp_CBE
62.95
38%
-34
- C1 -
-
2WPA
1
CDK2_HUMAN
A:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVW
P
G
V
T
---
S
M
----
P
--------
D
Y
K
P
--------
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
62.99
38%
-37
- C1 -
-
1Y91
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
62.97
38%
-39
- C1 -
-
3RPR
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
63.00
40%
-68
- C1 -
-
1UNG
1
CDK5_HUMAN
B:
[2-286]
----------
Q
K
Y
E
K
L
E
K
-------
T
V
F
K
A
--------
I
V
A
L
K
R
V
R
L
D
----
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
------
I
V
R
L
-----
H
D
V
---------
L
H
------
S
------
D
----
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
N
-
G
D
--
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
R
-
N
---
G
---
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
---
C
----
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
-
G
-
A
-
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
-------
T
P
T
E
---
E
Q
----
W
--------
P
S
M
T
--------
K
L
P
D
Y
K
P
Y
P
M
--
Y
P
----------
A
T
--
T
-
S
-
L
V
N
V
V
P
K
-----
L
N
A
T
G
---
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
62.93
38%
-34
- C1 -
-
2C4G
1
CDK2_HUMAN
A:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVW
P
G
V
T
---
S
M
----
P
--------
D
Y
K
P
--------
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
62.99
39%
-38
- C1 -
-
1GII
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
H
V
H
Q
D
L
K
T
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
62.98
38%
-37
- C1 -
-
2VV9
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
62.97
38%
-36
- C1 -
-
4LYN
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
62.90
38%
-33
- C1 -
-
2C4G
1
CDK2_HUMAN
C:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVW
P
G
V
T
---
S
M
----
P
--------
D
Y
K
P
--------
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
62.96
38%
-27
- C1 -
-
2C5O
1
CDK2_HUMAN
C:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
62.95
38%
-30
- C1 -
-
3QTU
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
62.93
38%
-33
- C1 -
-
5ANJ
1
CDK2_HUMAN
A:
[3-287]
-----------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
62.92
38%
-40
- C1 -
-
4FKQ
2
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
62.90
38%
-27
- C1 -
-
2WEV
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
192
Blastp_CBE
62.89
38%
-32
- C1 -
-
1YKR
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
180
Blastp_CBE
62.88
38%
-27
- C1 -
-
2C5N
1
CDK2_HUMAN
C:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
62.87
38%
-32
- C1 -
-
2WIH
1
CDK2_HUMAN
A:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVW
P
G
V
T
---
S
M
----
P
--------
D
Y
K
P
--------
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
62.82
38%
-33
- C1 -
-
6Q4J
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
--------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
62.78
38%
-29
- C1 -
-
2UUE
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
62.73
38%
-38
- C1 -
-
3R8Z
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
-----------
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
62.78
41%
-26
- C1 -
-
6GU2
1
CDK1_HUMAN
A:
[15-292]
------------------
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
-
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
------
I
V
S
L
-----
Q
D
V
---------
L
M
------
Q
------
D
----
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
P
-
P
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
D
D
-
K
---
G
---
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
---
V
----
Y
T
---
V
T
L
W
Y
R
S
P
E
V
L
L
-
G
S
A
-
R
-
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
-------
T
-
P
N
---
N
E
----
V
--------
W
P
E
V
--------
E
S
L
Q
D
Y
K
N
-
T
--
F
P
----------
K
W
--
K
---
P
G
S
L
A
-
S
-
H
V
K
N
L
D
E
N
G
---
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
62.76
38%
-47
- C1 -
-
1KE6
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
62.72
38%
-38
- C1 -
-
6Q4E
3
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
62.73
38%
-30
- C1 -
-
2C5X
1
CDK2_HUMAN
C:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
62.75
38%
-22
- C1 -
-
3PXQ
4
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
62.73
38%
-29
- C1 -
-
3EOC
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
62.72
38%
-35
- C1 -
-
1H0W
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
62.70
38%
-44
- C1 -
-
2R64
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
62.69
38%
-36
- C1 -
-
1H0V
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
---
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
62.59
38%
-37
- C1 -
-
6Q48
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
--------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
339
Blastp_CBE
62.60
38%
-33
- C1 -
-
2WXV
1
CDK2_HUMAN
C:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVW
P
G
V
T
---
S
M
----
P
--------
D
Y
K
P
--------
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
62.59
38%
-30
- C1 -
-
3EID
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
--
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
62.55
38%
-36
- C1 -
-
1E1X
2
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
62.54
38%
-40
- C1 -
-
1FVT
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
340
Blastp_CBE
62.52
38%
-33
- C1 -
-
2WXV
1
CDK2_HUMAN
A:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVW
P
G
V
T
---
S
M
----
P
--------
D
Y
K
P
--------
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
62.45
38%
-33
- C1 -
-
2WIH
1
CDK2_HUMAN
C:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVW
P
G
V
T
---
S
M
----
P
--------
D
Y
K
P
--------
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
62.45
38%
-40
- C1 -
-
3SW4
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
62.44
38%
-35
- C1 -
-
1PXM
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
Blastp_CBE
62.43
38%
-32
- C1 -
-
3LE6
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
62.42
38%
-40
- C1 -
-
3R7U
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
353
Blastp_CBE
62.33
38%
-29
- C1 -
-
1VYW
1
CDK2_HUMAN
C:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVW
P
G
V
T
---
S
M
----
P
--------
D
Y
K
P
--------
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
62.37
38%
-20
- C1 -
-
4GCJ
5
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
62.32
38%
-42
- C1 -
-
2VTA
3
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
62.33
38%
-39
- C1 -
-
2VTS
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
---------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
62.29
38%
-36
- C1 -
-
6Q3B
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
62.32
38%
-30
- C1 -
-
3F5X
2
CDK2_HUMAN
C:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
62.29
41%
-18
- C1 -
-
6GU6
1
CDK1_HUMAN
A:
[15-292]
------------------
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
-
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
------
I
V
S
L
-----
Q
D
V
---------
L
M
------
Q
------
D
----
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
P
-
P
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
D
D
-
K
---
G
---
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
----------
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
-
G
S
A
-
R
-
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
-------
T
-
P
N
---
N
E
----
V
--------
W
P
E
V
--------
E
S
L
Q
D
Y
K
N
-
T
--
F
P
----------
K
W
--
K
---
P
G
S
L
A
-
S
-
H
V
K
N
L
D
E
N
G
---
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
283
Blastp_CBE
62.24
38%
-37
- C1 -
-
3R9N
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
62.24
38%
-29
- C1 -
-
3SQQ
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
------
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
Blastp_CBE
62.27
38%
-35
- C1 -
-
4FKG
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
62.24
38%
-39
- C1 -
-
3FZ1
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
359
Blastp_CBE
62.23
38%
-28
- C1 -
-
5OO3
1
CDK2_HUMAN
A:
[7-292]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
A
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
161
Blastp_CBE
62.22
38%
-32
- C1 -
-
2I40
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Blastp_CBE
62.18
38%
-34
- C1 -
-
4FKI
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
62.14
38%
-43
- C1 -
-
2VTH
2
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
62.13
38%
-42
- C1 -
-
4FKP
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
62.13
38%
-38
- C1 -
-
4FKR
2
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
338
Blastp_CBE
62.05
38%
-24
- C1 -
-
3PXF
7
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
62.07
38%
-30
- C1 -
-
3RM6
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
-
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
235
Blastp_CBE
62.04
38%
-35
- C1 -
-
1E1V
2
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
179
Blastp_CBE
62.07
38%
-28
- C1 -
-
2C5O
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
62.06
38%
-40
- C1 -
-
1KE8
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
62.05
38%
-39
- C1 -
-
3R7I
2
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
62.04
38%
-42
- C1 -
-
2VTP
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
62.02
38%
-40
- C1 -
-
2A4L
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
------------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
228
Blastp_CBE
61.98
38%
-30
- C1 -
-
1FVV
1
CDK2_HUMAN
C:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
341
Blastp_CBE
61.99
38%
-33
- C1 -
-
2WPA
1
CDK2_HUMAN
C:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVW
P
G
V
T
---
S
M
----
P
--------
D
Y
K
P
--------
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
61.98
38%
-31
- C1 -
-
1PF8
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
61.97
38%
-35
- C1 -
-
1H08
2
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
61.93
38%
-35
- C1 -
-
3R8M
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
332
Blastp_CBE
61.82
38%
-19
- C1 -
-
3PY1
4
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
Blastp_CBE
61.88
38%
-38
- C1 -
-
3WBL
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
T
G
E
-
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
61.82
38%
-25
- C1 -
-
1FVV
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
197
Blastp_CBE
61.74
38%
-39
- C1 -
-
1VYZ
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
Blastp_CBE
61.72
38%
-39
- C1 -
-
4EK8
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
61.68
38%
-39
- C1 -
-
2UZN
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
61.65
38%
-36
- C1 -
-
3QTS
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
61.64
41%
-20
- C1 -
-
6GU4
1
CDK1_HUMAN
A:
[15-292]
------------------
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
-
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
------
I
V
S
L
-----
Q
D
V
---------
L
M
------
Q
------
D
----
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
P
-
P
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
D
D
-
K
---
G
---
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
---
V
----
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
-
G
S
A
-
R
-
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
-------
T
-
P
N
---
N
E
----
V
--------
W
P
E
V
--------
E
S
L
Q
D
Y
K
N
-
T
--
F
P
----------
K
W
--
K
---
P
G
S
L
A
-
S
-
H
V
K
N
L
D
E
N
G
---
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
61.63
38%
-32
- C1 -
-
3EOC
1
CDK2_HUMAN
C:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
61.61
38%
-28
- C1 -
-
2I40
1
CDK2_HUMAN
C:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
61.63
38%
-32
- C1 -
-
3NS9
1
CDK2_HUMAN
A:
[3-287]
-----------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
152
Blastp_CBE
61.61
38%
-27
- C1 -
-
2UUE
1
CDK2_HUMAN
C:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
61.52
38%
-36
- C1 -
-
3S0O
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
--
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
61.55
41%
-21
- C1 -
-
5HQ0
1
CDK1_HUMAN
A:
[15-292]
------------------
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
-
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
------
I
V
S
L
-----
Q
D
V
---------
L
M
------
Q
------
D
----
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
P
-
P
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
D
D
-
K
---
G
---
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
---
V
----
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
-
G
S
A
-
R
-
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
-------
T
-
P
N
---
N
E
----
V
--------
W
P
E
V
--------
E
S
L
Q
D
Y
K
N
-
T
--
F
P
----------
K
W
--
K
---
P
G
S
L
A
-
S
-
H
V
K
N
L
D
E
N
G
---
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
61.55
41%
-21
- C1 -
-
4Y72
1
CDK1_HUMAN
A:
[15-292]
------------------
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
-
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
------
I
V
S
L
-----
Q
D
V
---------
L
M
------
Q
------
D
----
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
P
-
P
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
D
D
-
K
---
G
---
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
---
V
----
Y
T
H
E
V
V
T
L
W
Y
R
S
P
E
V
L
L
-
G
S
A
-
R
-
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
-------
T
-
P
N
---
N
E
----
V
--------
W
P
E
V
--------
E
S
L
Q
D
Y
K
N
-
T
--
F
P
----------
K
W
--
K
---
P
G
S
L
A
-
S
-
H
V
K
N
L
D
E
N
G
---
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
61.51
38%
-28
- C1 -
-
1FIN
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
61.54
38%
-30
- C1 -
-
5JQ5
1
CDK2_HUMAN
A:
[3-287]
-----------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
61.53
38%
-37
- C1 -
-
2W06
2
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
61.52
38%
-35
- C1 -
-
5ANI
1
CDK2_HUMAN
A:
[2-287]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
61.51
38%
-39
- C1 -
-
5K4J
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
61.50
38%
-39
- C1 -
-
4FKT
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
231
Blastp_CBE
61.48
38%
-32
- C1 -
-
1FIN
1
CDK2_HUMAN
C:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
61.47
38%
-26
- C1 -
-
2X1N
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
189
Blastp_CBE
61.43
38%
-35
- C1 -
-
2B52
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
------------------
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
358
Blastp_CBE
61.42
38%
-23
- C1 -
-
5OSM
1
CDK2_HUMAN
A:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
A
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
61.38
38%
-36
- C1 -
-
3SW7
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
61.38
38%
-43
- C1 -
-
5ANK
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
--------------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
61.36
38%
-35
- C1 -
-
4FKV
2
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
Blastp_CBE
61.31
38%
-44
- C1 -
-
3S2P
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
61.31
38%
-43
- C1 -
-
5JQ8
1
CDK2_HUMAN
A:
[3-287]
-----------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
61.28
38%
-38
- C1 -
-
4FKS
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
61.24
38%
-40
- C1 -
-
1URW
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
61.24
38%
-42
- C1 -
-
2W17
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
-
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
-----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
-----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
525
Blastp_CBE
61.25
37%
-14
- C1 -
-
4CXA
1
CDK12_HUMAN
A:
[11-317]
--------
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
-
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
------
V
V
N
M
-----
K
E
I
VTDKQLD--
F
K
------
K
D-----
K
----
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
---
G
L
-
V
H
--
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
------
N
N
-
S
---
G
---
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
----
R
---
P
Y
N
K
-
V
I
T
L
W
Y
R
P
P
E
L
L
L
-
G
-
E
-
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
-
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S------
P
C
P
A
VWP
D
V
----
I
--------
K
L
------------
P
Y
F
N
T
M
-
K
---
P
----------
K
K
--
Q
-
Y
-
R
R
R
L
-
R
E
-
E
F
S
F
I
P
S
A
A
---
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
-----
T
L
Q
S
D
F
L
K
D
V
-
E
L
S
K
M
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
61.24
38%
-36
- C1 -
-
3ULI
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
-----
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
--------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Blastp_CBE
61.24
38%
-35
- C1 -
-
4FKJ
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
Blastp_CBE
61.21
38%
-38
- C1 -
-
4D1X
1
CDK2_HUMAN
A:
[3-287]
-----------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------------
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
61.19
38%
-23
- C1 -
-
4FX3
2
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
61.12
38%
-25
- C1 -
-
4FX3
1
CDK2_HUMAN
C:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
552
HHSearch
61.08
33%
-4
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[4-306]
--------
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
-
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
------
I
I
A
I
-----
K
D
I
---------
L
R
PTVPYG
E
------
F
----
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
----
S
-
Q
P
--
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
------
N
E
-
N
---
C
---
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQ
Y
---
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
-
S
L
H
-
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
-
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
-------
T
P
S
P
---
A
V
----
I
--------
Q
A
V
G
--------
A
E
R
-
V
R
A
Y
----
I
Q
----------
S
L
--
P
P
R
-
Q
P
V
P
W
E
T
-
V
Y
P
G
A
D
R
Q
A
---
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
435
Blastp_CBE
61.02
38%
-42
- C1 -
-
4CFU
1
CDK2_HUMAN
A:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVW
P
G
V
T
---
S
M
----
P
--------
D
Y
K
P
--------
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
60.97
38%
-34
- C1 -
-
2BHH
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
399
Blastp_CBE
60.84
38%
-44
- C1 -
-
5LMK
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
60.91
38%
-38
- C1 -
-
2IW8
1
CDK2_HUMAN
A:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
H
V
D
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVW
P
G
V
T
---
S
M
----
P
--------
D
Y
K
P
--------
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
60.85
38%
-35
- C1 -
-
3RPY
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
Blastp_CBE
60.87
38%
-37
- C1 -
-
4BGH
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
546
HHSearch
60.75
33%
-7
- C1 -
-
4ZSG
6
MK07_HUMAN
A:
[5-307]
--------
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
-
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
------
I
I
A
I
-----
K
D
I
---------
L
R
PTVPYG
E
------
F
----
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
----
S
-
Q
P
--
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
------
N
E
-
N
---
C
---
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQ
Y
---
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
-
S
L
H
-
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
-
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
-------
T
P
S
P
---
A
V
----
I
--------
Q
A
V
G
--------
A
E
R
-
V
R
A
Y
----
I
Q
----------
S
L
--
P
-
P
R
Q
P
V
P
W
E
T
-
V
Y
P
G
A
D
R
Q
A
---
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
60.85
38%
-29
- C1 -
-
4BZD
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
60.84
38%
-37
- C1 -
-
5OO1
1
CDK2_HUMAN
A:
[9-292]
------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
A
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
404
Blastp_CBE
60.82
38%
-44
- C1 -
-
3DDQ
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
60.81
39%
-38
- C1 -
-
1W8C
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
K
-
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
60.77
38%
-38
- C1 -
-
6GUK
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
60.76
38%
-36
- C1 -
-
1DM2
5
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
60.75
38%
-47
- C1 -
-
3TNW
1
CDK2_HUMAN
A:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
175
Blastp_CBE
60.72
38%
-29
- C1 -
-
2C5X
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
159
Blastp_CBE
60.74
38%
-34
- C1 -
-
2J9M
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
60.72
41%
-21
- C1 -
-
4YC3
1
CDK1_HUMAN
A:
[15-292]
------------------
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
-
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
R
H
P
N
------
I
V
S
L
-----
Q
D
V
---------
L
M
------
Q
------
D
----
S
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
---
I
P
-
P
G
QY
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
D
D
-
K
---
G
---
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
---
V
----
Y
T
---
V
T
L
W
Y
R
S
P
E
V
L
L
-
G
S
A
-
R
-
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
-
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
-------
T
-
P
N
---
N
E
----
V
--------
W
P
E
V
--------
E
S
L
Q
D
Y
K
N
-
T
--
F
P
----------
K
W
--
K
---
P
G
S
L
A
-
S
-
H
V
K
N
L
D
E
N
G
---
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
372
Blastp_CBE
60.64
38%
-49
- C1 -
-
4EOM
1
CDK2_HUMAN
A:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
--
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
60.59
38%
-35
- C1 -
-
2VTJ
2
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
60.59
38%
-30
- C1 -
-
3F5X
2
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
-
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
60.58
38%
-13
- C1 -
-
5EFQ
2
C:
[9-313]
--------
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
R
D
K
D
T
G
E
-
M
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
T
H
Q
S
------
I
I
N
M
-----
K
E
I
VTDKE------------------------
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
---
G
L
-
V
H
--
F
N
E
N
H
I
K
S
F
M
R
Q
L
M
E
G
L
D
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
------
N
N
-
R
---
G
---
Q
I
K
L
A
D
F
G
L
A
R
L
Y
S
S
E
E
S
---
R
---
P
Y
N
K
-
V
I
T
L
W
Y
R
P
P
E
L
L
L
-
G
-
E
-
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
-
K
K
P
I
F
Q
A
N
Q
E
L
A
Q
L
E
L
I
S
R
I
C
G
S------
P
C
P
A
VWP
D
V
----
I
--------
K
L
------------
P
Y
F
N
T
M
-
K
---
P
----------
K
K
--
Q
-
Y
-
R
R
K
L
R
E
E
-
F
V
F
I
-
P
A
A
A
---
L
D
L
F
D
Y
M
L
A
L
D
P
S
K
R
C
T
A
E
Q
A
L
-----
Q
C
E
F
L
R
D
V
-
E
P
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
343
Blastp_CBE
60.57
38%
-39
- C1 -
-
2WIP
1
CDK2_HUMAN
C:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVW
P
G
V
T
---
S
M
----
P
--------
D
Y
K
P
--------
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
496
Blastp_CBE
60.52
38%
-43
- C1 -
-
2IW9
1
CDK2_HUMAN
A:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
408
Blastp_CBE
60.51
38%
-46
- C1 -
-
2G9X
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
60.39
38%
-43
- C1 -
-
2IW6
1
CDK2_HUMAN
A:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
60.47
38%
-44
- C1 -
-
6GUB
1
CDK2_HUMAN
A:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
541
HHSearch
60.42
33%
-17
- C1 -
-
4IC7
1
MK07_HUMAN
A:
[53-354]
--------
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
-
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
------
I
I
A
I
-----
K
D
I
---------
L
R
------
P
TVPYGE
F
----
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
----
S
-
Q
P
--
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
------
N
E
-
N
---
C
---
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
---
E
HQY
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
-
S
L
H
-
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
-
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
-------
T
P
S
P
---
A
V
----
I
--------
Q
A
V
G
--------
A
E
R
-
V
R
A
Y
-
I
--
Q
S
----------
L
P
--
P
-
R
-
Q
P
V
P
W
E
T
-
V
Y
P
G
A
D
R
Q
A
---
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
164
Blastp_CBE
60.40
38%
-35
- C1 -
-
2DUV
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
-------------
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
395
Blastp_CBE
60.39
38%
-45
- C1 -
-
3BHU
1
CDK2_HUMAN
A:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
60.35
38%
-21
- C1 -
-
3PXZ
3
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
60.26
38%
-46
- C1 -
-
3BHT
1
CDK2_HUMAN
A:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
60.25
38%
-25
- C1 -
-
2C5V
1
CDK2_HUMAN
C:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
60.24
38%
-32
- C1 -
-
3EZV
1
CDK2_HUMAN
A:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
177
Blastp_CBE
60.18
38%
-31
- C1 -
-
2C5V
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
Blastp_CBE
60.13
38%
-33
- C1 -
-
3IG7
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
279
Blastp_CBE
60.12
38%
-34
- C1 -
-
3RAK
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
60.04
38%
-39
- C1 -
-
4EOR
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
WPGVTSMP
D
Y
K
P
--------
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
270
Blastp_CBE
60.07
38%
-30
- C1 -
-
3RMF
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
60.06
38%
-36
- C1 -
-
2WIP
1
CDK2_HUMAN
A:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVW
P
G
V
T
---
S
M
----
P
--------
D
Y
K
P
--------
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
182
Blastp_CBE
60.04
38%
-34
- C1 -
-
2BTS
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
60.02
38%
-38
- C1 -
-
5NEV
1
?
C:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
433
Blastp_CBE
60.01
38%
-39
- C1 -
-
4CFV
1
CDK2_HUMAN
A:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVW
P
G
V
T
---
S
M
----
P
--------
D
Y
K
P
--------
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
461
Blastp_CBE
60.00
38%
-33
- C1 -
-
6GUE
1
CDK2_HUMAN
C:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
-----------------TSMPDYKP
S
F
P
K
---
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
550
HHSearch
59.89
30%
-60
- C1 -
-
2WEL
7
KCC2D_HUMAN
A:
[2-273]
--------
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
-
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
------
I
V
R
L
-----
H
D
S
---------
I
S
------
E
------
E
----
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
---
A
R
-
E
Y
--
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
------
A
S
-
K
SKG
A
---
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
----
Q
---
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
-
K
-
D
-
P
-
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
-------
D
---------------------------------------------------------------
F
-
P
----
S
P
-
E
W
D
T
V
T
P
E
A
---
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
59.96
39%
-40
- C1 -
-
2R3P
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
K
-
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
59.89
38%
-34
- C1 -
-
3R9O
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
59.90
38%
-36
- C1 -
-
1V1K
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
---------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
Blastp_CBE
59.89
38%
-32
- C1 -
-
4ACM
3
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
59.87
38%
-42
- C1 -
-
1OIU
1
CDK2_HUMAN
A:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
59.86
38%
-31
- C1 -
-
3QTR
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
59.84
38%
-45
- C1 -
-
1OGU
1
CDK2_HUMAN
A:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
59.73
38%
-48
- C1 -
-
1OIY
1
CDK2_HUMAN
A:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
183
Blastp_CBE
59.82
38%
-36
- C1 -
-
2BTR
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
-------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
59.81
39%
-40
- C1 -
-
2R3I
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
K
-
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
425
Blastp_CBE
59.71
38%
-42
- C1 -
-
5NEV
1
CDK2_HUMAN
A:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
59.76
38%
-34
- C1 -
-
1GIH
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
59.78
38%
-32
- C1 -
-
2B55
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
59.77
38%
-33
- C1 -
-
3S1H
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
59.76
38%
-25
- C1 -
-
5A14
2
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
--
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
59.75
38%
-43
- C1 -
-
4EOJ
1
CDK2_HUMAN
A:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
59.65
38%
-44
- C1 -
-
4EOQ
1
CDK2_HUMAN
A:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
59.73
38%
-44
- C1 -
-
1E9H
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
59.71
38%
-38
- C1 -
-
1H00
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
510
Blastp_CBE
59.70
38%
-31
- C1 -
-
5MHQ
1
?
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
I
R
L
----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
402
Blastp_CBE
59.65
38%
-46
- C1 -
-
3DOG
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
449
Blastp_CBE
59.62
38%
-43
- C1 -
-
4EOK
1
CDK2_HUMAN
C:
[4-290]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
59.53
38%
-43
- C1 -
-
1H1S
1
CDK2_HUMAN
C:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
59.58
38%
-35
- C1 -
-
3RAL
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
376
Blastp_CBE
59.54
38%
-38
- C1 -
-
4EOS
1
CDK2_HUMAN
A:
[4-290]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
---
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVW
P
G
V
T
---
S
M
----
P
--------
D
Y
K
P
--------
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
473
Blastp_CBE
59.44
38%
-41
- C1 -
-
1OI9
1
CDK2_HUMAN
A:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
59.53
38%
-47
- C1 -
-
3MY5
3
CDK2_HUMAN
A:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
59.52
38%
-31
- C1 -
-
2VTQ
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
59.50
38%
-42
- C1 -
-
3BHT
1
CDK2_HUMAN
C:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
--------------------------------------------
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
59.48
38%
-36
- C1 -
-
4EK6
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
-----------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
59.44
38%
-38
- C1 -
-
4EOP
1
CDK2_HUMAN
A:
[4-290]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
59.38
38%
-40
- C1 -
-
1OIT
1
CDK2_HUMAN
A:
[3-287]
-----------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
-
G
E
-
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
S
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
59.27
38%
-42
- C1 -
-
3DDP
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
59.34
38%
-33
- C1 -
-
2W05
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
--------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
551
HHSearch
59.31
31%
-11
- C1 -
-
6KHF
1
CLK3_HUMAN
A:
[152-477]
--------
L
Q
E
D
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
---
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
KENKFL
C
V
L
M
-----
S
D
W
---------
F
N
------
F
------
H
----
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
---
N
N
F
Q
P
--
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
VNSEFS
V
K
-
N
---
T
---
S
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
----------
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
-
E
-
L
-
G
-
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
-
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
-------
P
I
P
S
---
H
M
----
I
--------
H
R
T
R
--------
K
Q
K
Y
F
Y
K
G
-
G
LV
W
D
ENSSDGRYVK
E
N
--
C
-
K
-
P
L
K
S
Y
M
L
-
Q
D
S
L
E
H
V
Q
L
---
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
59.30
38%
-43
- C1 -
-
1P5E
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
59.27
38%
-43
- C1 -
-
4EOO
1
CDK2_HUMAN
A:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
450
Blastp_CBE
59.26
38%
-43
- C1 -
-
4EOK
1
CDK2_HUMAN
A:
[4-290]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
405
Blastp_CBE
59.24
38%
-45
- C1 -
-
3DDP
1
CDK2_HUMAN
C:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
59.14
38%
-45
- C1 -
-
1OGU
1
CDK2_HUMAN
C:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
--------------------------------------------
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
407
Blastp_CBE
59.21
38%
-42
- C1 -
-
2G9X
1
CDK2_HUMAN
C:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
------------------------------------------
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
59.18
38%
-41
- C1 -
-
3BHU
1
CDK2_HUMAN
C:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
--------------------------------------------
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
59.17
38%
-43
- C1 -
-
2CCI
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
467
Blastp_CBE
59.07
38%
-41
- C1 -
-
4CFN
1
CDK2_HUMAN
A:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
59.15
38%
-45
- C1 -
-
1OI9
1
CDK2_HUMAN
C:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
59.14
38%
-17
- C1 -
-
4EZ7
7
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
59.13
39%
-38
- C1 -
-
2R3O
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
K
-
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
59.07
38%
-33
- C1 -
-
1R78
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
---------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
59.02
38%
-25
- C1 -
-
6GUH
3
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
--------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
--------
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
521
Blastp_CBE
58.91
37%
-0
- C1 -
-
4NST
3
C:
[11-317]
--------
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
-
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
------
V
V
N
M
-----
K
E
I
VT----------------D-----
K
----
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
---
G
L
-
V
H
--
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
------
N
N
-
S
---
G
---
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
-
E
S
---
R
---
P
Y
N
K
-
V
I
T
L
W
Y
R
P
P
E
L
L
L
-
G
-
E
-
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
-
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S------
P
C
P
A
VWP
D
V
----
I
--------
K
L
------------
P
Y
F
N
T
M
-
K
---
P
----------
K
K
--
Q
-
Y
-
R
R
R
L
-
R
E
-
E
F
S
F
I
P
S
A
A
---
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
-----
T
L
Q
S
D
F
L
K
D
V
-
E
L
S
K
M
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
516
Blastp_CBE
59.01
38%
-49
- C1 -
-
1UA2
1
CDK7_HUMAN
C:
[13-295]
-------------
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
T
N
Q
-
I
V
A
I
K
K
---------
I
N
R
T
A
L
R
E
I
K
L
L
Q
E
L
S
H
P
N
------
I
I
G
L
-----
L
D
A
---------
F
G
------
H
------
K
----
S
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
S
-
L
V
--
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
------
D
E
-
N
---
G
---
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R
---
A
---
Y
H
Q
--
V
V
T
R
W
Y
R
A
P
E
L
L
F
-
G
-
A
R
M
-
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
-
R
V
P
F
L
P
G
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
-------
T
P
T
E
---
E
Q
----
W
--------
P
D
M
C
--------
S
L
P
D
Y
V
T
F
-
K
S-
F
P
----------
G
I
PL
H
-
H
-
I
F
S
A
A
--------
G
D
D
L
---
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
460
Blastp_CBE
58.91
38%
-41
- C1 -
-
6GUF
1
CDK2_HUMAN
A:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
59.00
39%
-34
- C1 -
-
4ERW
17
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
K
-
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
58.91
38%
-41
- C1 -
-
5CYI
1
CDK2_HUMAN
A:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
58.98
38%
-31
- C1 -
-
2VTN
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
356
Blastp_CBE
58.97
38%
-40
* C1 *
-
4EOI
1
CDK2_HUMAN
C:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
D
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
58.93
38%
-37
- C1 -
-
4EOL
1
CDK2_HUMAN
A:
[4-290]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
--
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
-L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
58.92
38%
-40
- C1 -
-
1P5E
1
CDK2_HUMAN
C:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
398
Blastp_CBE
58.91
38%
-39
- C1 -
-
6GVA
3
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
--
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
58.89
38%
-33
- C1 -
-
6INL
1
?
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
58.88
38%
-45
- C1 -
-
3BHV
2
CDK2_HUMAN
A:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
58.82
38%
-43
- C1 -
-
1H1S
1
CDK2_HUMAN
A:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
58.80
38%
-43
- C1 -
-
2UZL
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
58.79
38%
-39
- C1 -
-
3BHV
1
CDK2_HUMAN
C:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
--------------------------------------------
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
523
Blastp_CBE
58.78
37%
9
- C1 -
-
5ACB
1
D:
[11-317]
--------
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
-
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
------
V
V
N
M
-----
K
E
I
VTDKQ----
F
K
------
K
D-----
K
----
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
---
G
L
-
V
H
--
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
------
N
N
-
S
---
G
---
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
---
S
---
R
---
P
Y
N
K
-
V
I
T
L
W
Y
R
P
P
E
L
L
L
-
G
-
E
-
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
-
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S------
P
C
P
A
VWP
D
V
----
I
--------
K
L
------------
P
Y
F
N
T
M
-
K
---
P
----------
K
K
--
Q
-
Y
-
R
R
R
L
-
R
E
-
E
F
S
F
I
P
S
A
A
---
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
-----
T
L
Q
S
D
F
L
K
D
V
-
E
L
S
K
M
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
495
Blastp_CBE
58.73
38%
-42
- C1 -
-
2IW9
1
CDK2_HUMAN
C:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
----------------------------------------------------------
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
58.70
39%
-36
- C1 -
-
2R3Q
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
K
-
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
58.69
38%
-27
- C1 -
-
2FVD
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
------------
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
--
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
524
Blastp_CBE
58.64
37%
14
- C1 -
-
5ACB
1
CDK12_HUMAN
C:
[11-317]
--------
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
-
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
------
V
V
N
M
-----
K
E
I
VTDKQDALD
F
K
------
K
D-----
K
----
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
---
G
L
-
V
H
--
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
------
N
N
-
S
---
G
---
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
---
R
---
P
Y
N
K
-
V
I
T
L
W
Y
R
P
P
E
L
L
L
-
G
-
E
-
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
-
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S------
P
C
P
A
VWP
D
V
----
I
--------
K
L
------------
P
Y
F
N
T
M
-
K
---
P
----------
K
K
--
Q
-
Y
-
R
R
R
L
-
R
E
-
E
F
S
F
I
P
S
A
A
---
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
-----
T
L
Q
S
D
F
L
K
D
V
-
E
L
S
K
M
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
484
Blastp_CBE
58.62
38%
-42
- C1 -
-
2UZD
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
58.59
38%
-29
- C1 -
-
1AQ1
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
--------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
58.53
38%
-50
- C1 -
-
6GUC
1
CDK2_HUMAN
A:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
-----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Blastp_CBE
58.51
38%
-28
- C1 -
-
3EZR
2
CDK2_HUMAN
A:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
-------------------------
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
58.50
38%
-42
- C1 -
-
5LMK
1
?
C:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
---------------------------------------------------------------
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
373
Blastp_CBE
58.38
38%
-38
- C1 -
-
4EON
1
CDK2_HUMAN
C:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
58.45
38%
-38
- C1 -
-
4EOI
2
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
D
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
58.41
38%
-33
- C1 -
-
1G5S
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
58.39
38%
-40
- C1 -
-
4BCM
1
CDK2_HUMAN
A:
[4-290]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
58.38
38%
-33
- C1 -
-
2IW8
1
CDK2_HUMAN
C:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
H
V
D
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T----------------------------------------------------------------------
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
520
Blastp_CBE
58.34
37%
-6
- C1 -
-
6CKX
1
CDK12_HUMAN
A:
[11-312]
--------
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
-
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
------
V
V
N
M
-----
K
E
I
VT----------------D-----
K
----
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
---
G
L
-
V
H
--
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
------
N
N
-
S
---
G
---
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
---
R
---
P
Y
N
K
-
V
I
T
L
W
Y
R
P
P
E
L
L
L
-
G
-
E
-
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
-
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S------
P
C
P
A
VWP
D
V
----
I
--------
K
L
------------
P
Y
F
N
T
M
-
K
---
P
----------
K
K
--
Q
-
Y
-
R
R
R
L
-
R
E
-
E
F
S
F
I
P
S
A
A
---
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
-----
T
L
Q
S
D
F
L
K
D
V
-
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
58.33
38%
-37
- C1 -
-
4CFW
1
CDK2_HUMAN
A:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
58.32
38%
-29
- C1 -
-
3RZB
1
CDK2_HUMAN
A:
[9-295]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
58.29
38%
-39
- C1 -
-
4BCN
1
CDK2_HUMAN
A:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
58.27
38%
-42
- C1 -
-
4EOM
1
CDK2_HUMAN
C:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
----------------------------------------
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
58.25
38%
-40
- C1 -
-
4CFN
1
CDK2_HUMAN
C:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
479
Blastp_CBE
58.14
38%
-37
- C1 -
-
2UZL
1
CDK2_HUMAN
C:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
58.14
38%
-38
- C1 -
-
4CFM
1
CDK2_HUMAN
A:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
512
Blastp_CBE
58.12
38%
-9
- C1 -
-
5EFQ
2
CDK13_HUMAN
A:
[9-313]
--------
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
R
D
K
D
T
G
E
-
M
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
T
H
Q
S
------
I
I
N
M
-----
K
E
I
VTDKE------------------------
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
---
G
L
-
V
H
--
F
N
E
N
H
I
K
S
F
M
R
Q
L
M
E
G
L
D
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
------
N
N
-
R
---
G
---
Q
I
K
L
A
D
F
G
L
A
R
L
Y
S
S
E
E
S
---
R
---
P
Y
N
K
-
V
I
T
L
W
Y
R
P
P
E
L
L
L
-
G
-
E
-
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
-
K
K
P
I
F
Q
A
N
Q
E
L
A
Q
L
E
L
I
S
R
I
C
G
S------
P
C
P
A
VWP
D
V
----
I
--------
K
L
------------
P
Y
F
N
T
M
-
K
---
P
----------
K
K
--
Q
-
Y
-
R
R
K
L
R
E
E
-
F
V
F
I
-
P
A
A
A
---
L
D
L
F
D
Y
M
L
A
L
D
P
S
K
R
C
T
A
E
Q
A
L
-----
Q
C
E
F
L
R
D
V
-
E
P
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
400
Blastp_CBE
58.22
38%
-43
- C1 -
-
5L2W
2
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
403
Blastp_CBE
58.18
38%
-36
- C1 -
-
3DDQ
1
CDK2_HUMAN
C:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
---------------------------------------------------------------
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
58.15
38%
-46
- C1 -
-
6GUC
1
CDK2_HUMAN
C:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
58.14
38%
-34
- C1 -
-
5FP5
3
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
-------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
-----------------------
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
470
Blastp_CBE
58.13
38%
-40
- C1 -
-
1OIU
1
CDK2_HUMAN
C:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
---------------------------------------------------------------
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
58.04
38%
-38
- C1 -
-
4EOL
1
CDK2_HUMAN
C:
[4-290]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
58.12
38%
-39
- C1 -
-
5CYI
1
CDK2_HUMAN
C:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
58.11
38%
-45
- C1 -
-
1H1Q
1
CDK2_HUMAN
A:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
482
Blastp_CBE
58.01
38%
-37
- C1 -
-
2UZE
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
58.04
38%
-26
- C1 -
-
5FP6
2
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
58.01
38%
-36
- C1 -
-
1H1P
1
CDK2_HUMAN
A:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
57.91
38%
-39
- C1 -
-
1QMZ
1
CDK2_HUMAN
C:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
57.98
38%
-43
- C1 -
-
6GUE
1
CDK2_HUMAN
A:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
-----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
N
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
382
Blastp_CBE
57.97
38%
-36
- C1 -
-
4BCO
1
CDK2_HUMAN
C:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
-------------------------------------------------------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
57.89
38%
-37
- C1 -
-
4BCO
1
CDK2_HUMAN
A:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
401
Blastp_CBE
57.92
38%
-38
- C1 -
-
3DOG
1
CDK2_HUMAN
C:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
-------------------------------------------------------------
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
57.91
39%
-29
- C1 -
-
1GIJ
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
-----------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
H
V
H
Q
D
L
K
T
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
374
Blastp_CBE
57.89
38%
-37
- C1 -
-
4EON
1
CDK2_HUMAN
A:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
57.88
38%
-37
- C1 -
-
4BCP
1
CDK2_HUMAN
A:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
57.87
38%
-36
- C1 -
-
4EOS
1
CDK2_HUMAN
C:
[4-290]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TPDEVVW
P
G
V
T
---
S
M
----
P
--------
D
Y
K
P
--------
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
57.85
38%
-40
- C1 -
-
1PYE
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
-----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
57.84
38%
-39
- C1 -
-
1H1R
1
CDK2_HUMAN
C:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
57.76
38%
-40
- C1 -
-
1JST
1
CDK2_HUMAN
C:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
478
Blastp_CBE
57.71
38%
-34
- C1 -
-
4II5
2
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
57.68
38%
-42
- C1 -
-
1H1R
1
CDK2_HUMAN
A:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
57.66
38%
-34
- C1 -
-
5ANG
1
CDK2_HUMAN
A:
[2-287]
----------
E
N
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
----------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
-------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
497
Blastp_CBE
57.63
38%
-38
- C1 -
-
2IW6
1
CDK2_HUMAN
C:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
57.53
38%
-42
- C1 -
-
4CFW
1
CDK2_HUMAN
C:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
57.51
38%
-34
- C1 -
-
4II5
3
CDK2_HUMAN
C:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
490
Blastp_CBE
57.59
38%
-40
- C1 -
-
2C6T
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
57.54
38%
-39
- C1 -
-
2UZE
1
CDK2_HUMAN
C:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
57.53
38%
-37
- C1 -
-
4BCP
1
CDK2_HUMAN
C:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
--------------------------------------------
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
57.51
38%
-38
- C1 -
-
6GUB
1
?
C:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
------
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
57.47
38%
-28
- C1 -
-
2VU3
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
---------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
----
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
57.46
38%
-42
- C1 -
-
4EOR
1
CDK2_HUMAN
C:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
------------------------------------------
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
420
Blastp_CBE
57.44
38%
-42
- C1 -
-
1PKD
1
CDK2_HUMAN
C:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
489
Blastp_CBE
57.40
38%
-42
- C1 -
-
2C6T
1
CDK2_HUMAN
C:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
57.39
38%
-40
- C1 -
-
2UZB
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
57.38
37%
-6
- C1 -
-
6CKX
1
C:
[11-312]
--------
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
-
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
------
V
V
N
M
-----
K
E
I
VT----------------D-----
K
----
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
---
G
L
-
V
H
--
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
------
N
N
-
S
---
G
---
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
---
R
---
P
Y
N
K
-
V
I
T
L
W
Y
R
P
P
E
L
L
L
-
G
-
E
-
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
-
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S------
P
C
P
A
VWP
D
V
----
I
--------
K
L
------------
P
Y
F
N
T
M
-
K
---
P
----------
K
K
--
Q
-
Y
-
R
R
R
L
-
R
E
-
E
F
S
F
I
P
S
A
A
---
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
-----
T
L
Q
S
D
F
L
K
D
V
-
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
57.34
38%
-43
- C1 -
-
2UZD
1
CDK2_HUMAN
C:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
418
Blastp_CBE
57.26
38%
-38
- C1 -
-
1GY3
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
57.16
38%
-40
- C1 -
-
1OIY
1
CDK2_HUMAN
C:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
367
Blastp_CBE
57.25
38%
-39
- C1 -
-
4EOP
1
CDK2_HUMAN
C:
[4-290]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
434
Blastp_CBE
57.16
38%
-33
- C1 -
-
4CFU
1
CDK2_HUMAN
C:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TP----------------------------------------------------
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
57.23
38%
-34
- C1 -
-
2VTT
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
57.22
38%
-34
- C1 -
-
3QHR
2
CDK2_HUMAN
C:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
57.17
38%
-42
- C1 -
-
2CCI
1
CDK2_HUMAN
C:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
57.16
38%
-40
- C1 -
-
3MY5
1
CDK2_HUMAN
C:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-------------------------------------------------------------
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
513
Blastp_CBE
57.14
37%
-3
- C1 -
-
6B3E
3
C:
[8-314]
---------
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
-
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
------
V
V
N
M
-----
K
E
I
VT----------------D-----
K
----
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
---
G
L
-
V
H
--
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
------
N
N
-
S
---
G
---
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
---
R
---
P
Y
N
K
-
V
I
T
L
W
Y
R
P
P
E
L
L
L
-
G
-
E
-
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
-
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S------
P
C
P
A
VWP
D
V
----
I
--------
K
L
------------
P
Y
F
N
T
M
-
K
---
P
----------
K
K
--
Q
-
Y
-
R
R
R
L
-
R
E
-
E
F
S
F
I
P
S
A
A
---
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
V
E
L
S
K
M
-
A
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
57.13
38%
-44
- C1 -
-
1H1Q
1
CDK2_HUMAN
C:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
57.02
38%
-37
- C1 -
-
3QHR
6
CDK2_HUMAN
A:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
57.12
38%
-36
- C1 -
-
4BCM
1
CDK2_HUMAN
C:
[4-290]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
57.09
38%
-34
- C1 -
-
1E9H
1
CDK2_HUMAN
C:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
56.98
38%
-41
- C1 -
-
2UZB
1
CDK2_HUMAN
C:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
56.94
38%
-39
- C1 -
-
1GY3
2
CDK2_HUMAN
C:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
57.02
38%
-35
- C1 -
-
1H1P
1
CDK2_HUMAN
C:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
56.99
39%
-40
- C1 -
-
2R3J
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
K
-
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
56.98
38%
-42
- C1 -
-
4EOO
1
CDK2_HUMAN
C:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
56.94
38%
-37
- C1 -
-
1QMZ
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
499
Blastp_CBE
56.93
38%
-34
- C1 -
-
4I3Z
3
CDK2_HUMAN
C:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
56.89
38%
-35
- C1 -
-
4CFX
1
CDK2_HUMAN
C:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
421
Blastp_CBE
56.86
38%
-40
- C1 -
-
1PKD
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
429
Blastp_CBE
56.79
38%
-38
- C1 -
-
4CFX
1
CDK2_HUMAN
A:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
56.77
38%
-36
- C1 -
-
6GUF
1
CDK2_HUMAN
C:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
56.76
39%
-41
- C1 -
-
2R3K
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
K
-
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
56.74
38%
-47
- C1 -
-
4BCK
1
CDK2_HUMAN
C:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
56.66
38%
-34
- C1 -
-
2CCH
3
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
502
Blastp_CBE
56.55
38%
-35
- C1 -
-
3QHW
2
CDK2_HUMAN
A:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
56.65
39%
-42
- C1 -
-
2R3L
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
----------------------
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
K
-
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
56.59
38%
-41
- C1 -
-
4EOQ
1
CDK2_HUMAN
C:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
----------------------------------------
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
56.51
38%
-40
- C1 -
-
3TNW
1
CDK2_HUMAN
C:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
56.58
38%
-36
- C1 -
-
1OIQ
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
-------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
-----------------------
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
500
Blastp_CBE
56.56
38%
-34
- C1 -
-
4I3Z
4
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
56.55
39%
-41
- C1 -
-
2R3M
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
K
-
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
56.51
38%
-42
- C1 -
-
4BCK
2
CDK2_HUMAN
A:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
56.47
38%
-36
- C1 -
-
3QHW
3
CDK2_HUMAN
C:
[3-289]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
56.42
38%
-41
- C1 -
-
4BCQ
1
CDK2_HUMAN
C:
[4-290]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
56.39
38%
-35
- C1 -
-
1P2A
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
----------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
56.30
37%
-1
- C1 -
-
6B3E
1
CDK12_HUMAN
A:
[8-314]
---------
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
-
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
------
V
V
N
M
-----
K
E
I
VT----------------D-----
K
----
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
---
G
L
-
V
H
--
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
------
N
N
-
S
---
G
---
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
---
R
---
P
Y
N
K
-
V
I
T
L
W
Y
R
P
P
E
L
L
L
-
G
-
E
-
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
-
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S------
P
C
P
A
VWP
D
V
----
I
--------
K
L
------------
P
Y
F
N
T
M
-
K
---
P
----------
K
K
--
Q
-
Y
-
R
R
R
L
-
R
E
-
E
F
S
F
I
P
S
A
A
---
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
V
E
L
S
K
M
-
A
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
522
Blastp_CBE
56.25
37%
10
- C1 -
-
4NST
3
CDK12_HUMAN
A:
[11-317]
--------
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
-
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
------
V
V
N
M
-----
K
E
I
VTDKQD-----------------------
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
---
G
L
-
V
H
--
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
------
N
N
-
S
---
G
---
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
---
R
---
P
Y
N
K
-
V
I
T
L
W
Y
R
P
P
E
L
L
L
-
G
-
E
-
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
-
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S------
P
C
P
A
VWP
D
V
----
I
--------
K
L
------------
P
Y
F
N
T
M
-
K
---
P
----------
K
K
--
Q
-
Y
-
R
R
R
L
-
R
E
-
E
F
S
F
I
P
S
A
A
---
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
-----
T
L
Q
S
D
F
L
K
D
V
-
E
L
S
K
M
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
493
Blastp_CBE
56.24
38%
-39
- C1 -
-
1JST
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
56.21
38%
-38
- C1 -
-
4CFM
1
CDK2_HUMAN
C:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
--------------------------------------------------------------
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
456
Blastp_CBE
56.14
38%
-46
- C1 -
-
4BCQ
1
CDK2_HUMAN
A:
[4-290]
---------
M
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
432
Blastp_CBE
55.97
38%
-39
- C1 -
-
4CFV
1
CDK2_HUMAN
C:
[6-292]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
TP---------------------------------------------------------------------
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
55.79
38%
-32
- C1 -
-
2CCH
1
CDK2_HUMAN
C:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
55.76
39%
-33
- C1 -
-
4NJ3
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
--------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
-------------------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
K
-
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Blastp_CBE
55.71
38%
-32
- C1 -
-
5D1J
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
--------------
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
55.49
38%
-39
- C1 -
-
4EOJ
1
CDK2_HUMAN
C:
[5-291]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
------------------
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
494
Blastp_CBE
53.82
38%
-38
- C1 -
-
1FQ1
1
CDK2_HUMAN
B:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---
V
---
R
T
Y
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
Blastp_CBE
53.57
38%
-29
- C1 -
-
4D1Z
2
CDK2_HUMAN
A:
[3-287]
-----------
N
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
------------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------------
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
------------------------
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
51.07
39%
-38
- C1 -
-
2R3N
1
CDK2_HUMAN
A:
[2-288]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
K
-
Y
-
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
48.10
38%
-10
- C1 -
-
4RJ3
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
I
R
L
D
T
E
--------
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
509
Blastp_CBE
37.96
38%
-24
- C1 -
-
1H01
3
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
I
R
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
508
Blastp_CBE
37.53
38%
-20
- C1 -
-
1OIR
1
CDK2_HUMAN
A:
[1-287]
---------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
-
V
V
A
L
K
I
R
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
------
I
V
K
L
-----
L
D
V
---------
I
H
------
T
------
E
----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
---
S
A
L
T
G
--
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
------
N
T
-
E
---
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
-------
T
-
P
D
---
E
V
----
V
--------
W
P
G
V
TSMPDYKP
S
F
P
K
W
A
R
Q
-
D
--
F
S
----------
K
V
--
V
-
P
-
P
L
D
E
D
G
R
--------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------