@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CHK1_HUMAN: (2020-09-07 )
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
Atome Classification :
(411 SA)
....---.....10.---.......20.....-...30..----.-......40-.---..--.--.--.--.---.--.--50---..--.-------.....60.---.......70.........80........90.....-...100.......110.-......120.......130.....---.---.----140--.---------.-----.--.....150....--...160.......170.......180-........190.......200.....-.--.210-.--..--------....-..220-.--..-.-..-----..----230-.........240----.........250..-----....----.260..----..----...270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAVP---FVE
D
W
D
L
V
---
Q
T
L
GEGAY
G
E
V
Q
L
A
-
V
N
R
V-TE----E-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
--A--V--D---C--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
ML---
N
H
E
N
V
V
K
F
-YGHRREG
N
I
Q
Y
L
F
L
E
YCSGG
E
L
F
D
RI-EPDIGMPEP
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
HGIGITHRDIKPENLL---L---D----ER---D---------N-----
L
--
K
ISDF
G
L
A
T
V
F
R--YN
N
R
E
R
L
L
N
K
M
CGTL
P
Y
V
A
P
E
L
L
K
R
--
R
EFHAEP
V
D
V
W
S
C
G
I
V
L
T
A
M
L
AGELP-W--DQ---P--S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-TY-----L
N
----
P
---
W
K
KIDS
A
P
L
A
------
L
L
H
K
I
L
VENPS
A
R
I
-----TIPD----IKKDRW----YN----K
P
L
KKGAKRPRVTSGGVSESP
S
G
F
S
K
H
I
Q
SNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDT
S
P
S
Y
I
D
K
L
V
QGISFSQPTCPDH
M
L
LNSQLLGTPGSSQ
N
P
W
Q
R
L
V
K
R
M
T
R
F
F
T
KLDAD
K
S
Y
Q
C
L
K
E
T
C
E
K
L
G
Y
Q
W
K
K
S
CMN
Q
V
T
I
S
TTDRRN
N
K
L
I
F
K
V
N
L
LEMD
D
K
I
L
V
D
F
R
LSKGD
G
L
E
F
K
R
H
F
L
K
IK
G
K
L
I
D
I
VSS
Q
K
I
WLPAT
5
PsiBlast_PDB
93.60
100%
-99
- C3 -
-
3TKI
1
CHK1_HUMAN
A:
[2-280]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
93.04
100%
-93
- C3 -
-
2X8D
1
CHK1_HUMAN
A:
[2-280]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
--
A
--
V
--
D
---
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
92.35
100%
-91
- C3 -
-
2YDI
1
CHK1_HUMAN
A:
[2-280]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
--
A
--
V
--
D
---
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
92.04
97%
-107
- C3 -
-
5OOR
1
CHK1_HUMAN
A:
[3-283]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-----------------------
N
---
I
K
--
K
-------
E
I
C
I
L
K
M
L
---
N
H
E
N
V
I
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
A
D
Y
S
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
G
G
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
92.02
100%
-95
- C3 -
-
2HY0
1
CHK1_HUMAN
A:
[1-279]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
91.96
99%
-96
- C3 -
-
4QYE
1
CHK1_HUMAN
A:
[3-280]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
91.82
100%
-101
- C3 -
-
4FSR
1
CHK1_HUMAN
A:
[2-279]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
--
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
91.68
99%
-97
- C3 -
-
4FT3
6
CHK1_HUMAN
A:
[2-279]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
----------------------
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
576
HHSearch
91.30
100%
-90
- C3 -
-
1ZLT
1
CHK1_HUMAN
A:
[2-276]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
------------
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
91.20
100%
-96
- C3 -
-
2HXL
1
CHK1_HUMAN
A:
[1-275]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
------------
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
91.15
100%
-98
- C3 -
-
2QHN
1
CHK1_HUMAN
A:
[2-280]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
----
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
91.08
99%
-90
- C3 -
-
1ZLT
1
CHK1_HUMAN
A:
[2-276]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
------------
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
Blastp_CBE
91.07
100%
-100
- C3 -
-
6FCK
1
CHK1_HUMAN
A:
[2-270]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
--
A
--
V
--
D
---
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
90.99
100%
-103
- C3 -
-
2AYP
1
CHK1_HUMAN
A:
[2-269]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
--
A
--
V
--
D
---
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
Blastp_CBE
90.96
100%
-95
- C3 -
-
4FT7
4
CHK1_HUMAN
A:
[2-279]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
Blastp_CBE
90.91
99%
-93
- C3 -
-
4FSN
2
CHK1_HUMAN
A:
[1-278]
--
A
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
----------------------
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
90.89
100%
-99
- C3 -
-
3TKH
1
CHK1_HUMAN
A:
[2-280]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
------------------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
90.87
100%
-94
- C3 -
-
2R0U
1
CHK1_HUMAN
A:
[2-280]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
---
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
90.78
100%
-96
- C3 -
-
2E9U
1
CHK1_HUMAN
A:
[1-269]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
--
A
--
V
--
D
---
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
Blastp_CBE
90.77
100%
-102
- C3 -
-
6FC8
1
CHK1_HUMAN
A:
[2-270]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
--
A
--
V
--
D
---
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
90.70
98%
-95
- C3 -
-
2BRB
1
CHK1_HUMAN
A:
[2-276]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
------------
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
574
HHSearch
90.63
97%
-114
- C3 -
-
5OQ5
2
CHK1_HUMAN
A:
[3-270]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
------------
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
L
K
M
L
---
N
H
E
N
V
I
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
A
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
90.65
98%
-97
- C3 -
-
2BRO
1
CHK1_HUMAN
A:
[2-276]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
------------
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
90.64
100%
-94
- C3 -
-
2HOG
1
CHK1_HUMAN
A:
[1-279]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
90.63
97%
-114
- C3 -
-
5OQ5
2
CHK1_HUMAN
A:
[3-270]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
------------
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
L
K
M
L
---
N
H
E
N
V
I
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
A
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
90.51
99%
-97
- C3 -
-
4FTC
4
CHK1_HUMAN
A:
[1-279]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
----
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Blastp_CBE
90.50
100%
-97
- C3 -
-
4FTI
3
CHK1_HUMAN
A:
[2-278]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
----------------------
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
90.47
100%
-95
- C3 -
-
2QHM
1
CHK1_HUMAN
A:
[2-280]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
----
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
90.40
99%
-96
- C3 -
-
4QYF
1
CHK1_HUMAN
A:
[3-280]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
--
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
90.36
100%
-104
- C3 -
-
2E9V
1
CHK1_HUMAN
B:
[1-268]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
--
A
--
V
--
D
---
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
90.25
100%
-98
- C3 -
-
4FTU
4
CHK1_HUMAN
A:
[2-279]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
90.21
99%
-94
- C3 -
-
4FSZ
3
CHK1_HUMAN
A:
[2-279]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
--
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
---------------------
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
90.19
100%
-89
- C3 -
-
2HXQ
1
CHK1_HUMAN
A:
[1-275]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
------------
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Blastp_CBE
90.10
100%
-96
- C3 -
-
4FT9
1
CHK1_HUMAN
A:
[1-279]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
--
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
----------------------
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
90.01
99%
-91
- C3 -
-
1ZYS
1
CHK1_HUMAN
A:
[3-273]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
--
A
--
V
--
D
---
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
A
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
Blastp_CBE
89.93
100%
-104
- C3 -
-
4FT5
2
CHK1_HUMAN
A:
[2-279]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
-----
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
89.87
100%
-100
- C3 -
-
4FTJ
3
CHK1_HUMAN
A:
[2-278]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
----------------------------------
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
89.68
100%
-97
- C3 -
-
1NVQ
1
CHK1_HUMAN
A:
[3-273]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
89.67
100%
-102
- C3 -
-
2E9V
1
CHK1_HUMAN
A:
[1-268]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
--
A
--
V
--
D
---
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
89.63
100%
-97
- C3 -
-
4FT0
2
CHK1_HUMAN
A:
[2-279]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
--------------------------
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
----
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
89.58
100%
-96
- C3 -
-
4FTT
4
CHK1_HUMAN
A:
[2-279]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
---
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---------------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
89.55
99%
-97
- C3 -
-
4FSY
3
CHK1_HUMAN
A:
[2-279]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
--
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--------------------------
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
89.47
98%
-95
- C3 -
-
2BR1
1
CHK1_HUMAN
A:
[2-276]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
------------
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
89.41
99%
-100
- C3 -
-
4RVM
1
CHK1_HUMAN
A:
[3-273]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
89.32
100%
-97
- C3 -
-
2E9N
1
CHK1_HUMAN
A:
[1-269]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
--
A
--
V
--
D
---
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
Blastp_CBE
89.29
100%
-97
- C3 -
-
4FSM
3
CHK1_HUMAN
A:
[2-279]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
---
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
------------------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
89.24
100%
-99
- C3 -
-
4FSQ
1
CHK1_HUMAN
A:
[2-279]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
----
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
----------------------------------
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
89.16
100%
-90
- C3 -
-
2YER
7
CHK1_HUMAN
A:
[2-269]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
--
A
--
V
--
D
---
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
Blastp_CBE
89.03
99%
-97
- C3 -
-
4FTA
4
CHK1_HUMAN
A:
[2-279]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
---
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
------------------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
89.01
99%
-96
- C3 -
-
4QYG
1
CHK1_HUMAN
B:
[3-273]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
88.97
100%
-93
- C3 -
-
2YWP
1
CHK1_HUMAN
A:
[1-269]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
--
A
--
V
--
D
---
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
88.96
100%
-104
- C3 -
-
4FTL
2
CHK1_HUMAN
A:
[2-279]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
-----
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
------------------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
88.82
100%
-88
- C3 -
-
4HYI
4
CHK1_HUMAN
A:
[3-274]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
---------------
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
88.82
99%
-99
- C3 -
-
4RVK
1
CHK1_HUMAN
A:
[3-273]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
88.81
100%
-102
- C3 -
-
4FTM
5
CHK1_HUMAN
A:
[2-279]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
-----
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
------------------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
88.80
97%
-107
- C3 -
-
5OP7
1
CHK1_HUMAN
A:
[4-270]
---
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-------------------
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
L
K
M
L
---
N
H
E
N
V
I
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
A
D
Y
S
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
575
HHSearch
88.76
100%
-97
- C3 -
-
2YWP
1
CHK1_HUMAN
A:
[2-267]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
--
A
--
V
--
D
---
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
88.65
98%
-97
- C3 -
-
2BRN
1
CHK1_HUMAN
A:
[6-276]
--------
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
------------
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
88.63
100%
-95
- C3 -
-
2GHG
1
CHK1_HUMAN
A:
[1-269]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
--
A
--
V
--
D
---
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
88.63
99%
-95
- C3 -
-
4QYH
1
CHK1_HUMAN
A:
[3-273]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
577
HHSearch
88.56
100%
-89
- C3 -
-
2YEX
8
CHK1_HUMAN
A:
[2-270]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
--
A
--
V
--
D
---
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Blastp_CBE
88.56
100%
-89
- C3 -
-
2YEX
8
CHK1_HUMAN
A:
[2-270]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
--
A
--
V
--
D
---
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
88.44
97%
-106
- C3 -
-
5OPV
1
CHK1_HUMAN
A:
[3-270]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
----------------------
E
N
---
I
K
--
K
-------
E
I
C
I
L
K
M
L
---
N
H
E
N
V
I
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
A
D
Y
S
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
88.39
99%
-97
- C3 -
-
4FSW
2
CHK1_HUMAN
A:
[2-279]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
--
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
------------------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
88.33
100%
-99
- C3 -
-
3OT3
1
CHK1_HUMAN
A:
[4-270]
-------
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
----------------------
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
88.33
100%
-102
- C3 -
-
4FTK
2
CHK1_HUMAN
A:
[2-279]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
-----
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
------------------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
88.31
100%
-93
- C3 -
-
1NVR
1
CHK1_HUMAN
A:
[3-273]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
88.26
99%
-97
- C3 -
-
4GH2
4
CHK1_HUMAN
A:
[2-279]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
------------------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
88.23
100%
-104
- C3 -
-
2X8E
1
CHK1_HUMAN
A:
[9-270]
-----------
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
------------
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
88.15
99%
-92
- C3 -
-
2GDO
1
CHK1_HUMAN
A:
[1-273]
M
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
---------------
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
88.14
99%
-98
- C3 -
-
2CGU
1
CHK1_HUMAN
A:
[6-271]
--------
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
------------
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
88.04
99%
-93
- C3 -
-
4QYG
1
CHK1_HUMAN
A:
[3-273]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
88.03
97%
-106
- C3 -
-
5OPU
1
CHK1_HUMAN
A:
[3-271]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-----------------------
N
---
I
K
--
K
-------
E
I
C
I
L
K
M
L
---
N
H
E
N
V
I
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
A
D
Y
S
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
88.01
100%
-89
- C3 -
-
2E9O
1
CHK1_HUMAN
A:
[1-269]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
--
A
--
V
--
D
---
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Blastp_CBE
88.00
100%
-93
- C3 -
-
1NVS
1
CHK1_HUMAN
A:
[3-273]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
87.90
100%
-91
- C3 -
-
2E9P
1
CHK1_HUMAN
A:
[1-269]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
--
A
--
V
--
D
---
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
87.85
99%
-95
- C3 -
-
4QYH
1
CHK1_HUMAN
B:
[3-273]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
87.79
100%
-94
- C3 -
-
4HYH
1
CHK1_HUMAN
A:
[4-272]
---
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
87.77
97%
-108
- C3 -
-
5OOT
1
CHK1_HUMAN
A:
[4-270]
---
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
----------------------
E
N
---
I
K
--
K
-------
E
I
C
I
L
K
M
L
---
N
H
E
N
V
I
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
A
D
Y
S
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
87.76
98%
-100
- C3 -
-
2C3L
1
CHK1_HUMAN
A:
[2-273]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
-----------------------
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
Blastp_CBE
87.73
99%
-96
- C3 -
-
4FSU
3
CHK1_HUMAN
A:
[3-270]
---
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
A
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
--------------------------
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
87.68
97%
-102
- C3 -
-
5OOP
1
CHK1_HUMAN
A:
[5-271]
-------
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
-----------------
V
--
D
---
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
L
K
M
L
---
N
H
E
N
V
I
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
A
D
Y
S
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
87.49
100%
-95
- C3 -
-
3PA3
1
CHK1_HUMAN
A:
[4-270]
-------
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
87.46
97%
-104
- C3 -
-
5OP5
1
CHK1_HUMAN
A:
[4-270]
---
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-----------------------
N
---
I
K
--
K
-------
E
I
C
I
L
K
M
L
---
N
H
E
N
V
I
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
A
D
Y
S
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
87.45
97%
-105
- C3 -
-
5OP4
1
CHK1_HUMAN
A:
[3-270]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---------------------------
N
---
I
K
--
K
-------
E
I
C
I
L
K
M
L
---
N
H
E
N
V
I
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
A
D
Y
S
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
87.35
97%
-105
- C3 -
-
5OP2
1
CHK1_HUMAN
A:
[4-271]
---
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
----------------
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
L
K
M
L
---
N
H
E
N
V
I
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
A
D
Y
S
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
87.27
100%
-105
- C3 -
-
2XEY
1
CHK1_HUMAN
A:
[6-269]
--------
V
E
D
W
D
L
V
---
Q
T
L
G
----
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
--------------------------
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
87.26
97%
-105
- C3 -
-
5OPS
1
CHK1_HUMAN
A:
[3-270]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
------------------------------
N
---
I
K
--
K
-------
E
I
C
I
L
K
M
L
---
N
H
E
N
V
I
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
A
D
Y
S
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
87.26
99%
-95
- C3 -
-
2CGX
1
CHK1_HUMAN
A:
[6-273]
--------
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
------------
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
Blastp_CBE
87.25
96%
-106
- C3 -
-
5OQ8
1
CHK1_HUMAN
A:
[4-270]
---
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
S
F
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-------------------
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
L
K
M
L
---
N
H
E
N
V
I
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
A
D
Y
S
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
87.21
99%
-103
- C3 -
-
4FST
5
CHK1_HUMAN
A:
[2-269]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
----
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
------------------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
Blastp_CBE
87.13
100%
-87
- C3 -
-
2YDK
6
CHK1_HUMAN
A:
[3-270]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
------------------
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
87.05
96%
-110
- C3 -
-
5OQ6
1
CHK1_HUMAN
A:
[5-270]
-------
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
S
F
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---------------------------
N
---
I
K
--
K
-------
E
I
C
I
L
K
M
L
---
N
H
E
N
V
I
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
A
D
Y
S
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
87.04
100%
-96
- C3 -
-
2X8I
2
CHK1_HUMAN
A:
[2-269]
-
A
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
----------------------
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Blastp_CBE
86.94
100%
-102
- C3 -
-
5F4N
8
CHK1_HUMAN
A:
[5-271]
-------
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---------------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
86.93
98%
-95
- C3 -
-
2C3K
1
CHK1_HUMAN
A:
[6-270]
--------
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
------------
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
86.74
99%
-97
- C3 -
-
3NLB
1
CHK1_HUMAN
A:
[6-271]
--------
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
------------------
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
Blastp_CBE
86.72
100%
-97
- C3 -
-
3PA4
4
CHK1_HUMAN
A:
[5-270]
--------
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
86.62
99%
-101
- C3 -
-
4RVL
1
CHK1_HUMAN
A:
[3-273]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
------
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
86.46
99%
-93
- C3 -
-
2CGV
1
CHK1_HUMAN
A:
[6-272]
--------
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
------------
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
86.42
99%
-94
- C3 -
-
2CGW
1
CHK1_HUMAN
A:
[6-271]
--------
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
---------------
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
86.33
97%
-105
- C3 -
-
5OPR
1
CHK1_HUMAN
A:
[4-270]
---
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---------------------------
N
---
I
K
--
K
-------
E
I
C
I
L
K
M
L
---
N
H
E
N
V
I
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
A
D
Y
S
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
86.32
99%
-101
- C3 -
-
4FTQ
3
CHK1_HUMAN
A:
[2-269]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
--
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
----------------------------------
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
86.31
98%
-96
- C3 -
-
2BRH
1
CHK1_HUMAN
A:
[6-271]
--------
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---------------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
86.18
98%
-100
- C3 -
-
2C3J
1
CHK1_HUMAN
A:
[6-270]
--------
V
E
D
W
D
L
V
---
Q
T
L
G
E
---
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
--
R
------------------
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
86.08
98%
-95
- C3 -
-
2BRG
1
CHK1_HUMAN
A:
[7-269]
---------
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
K
---------------------
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
86.07
97%
-100
- C3 -
-
5OPB
1
CHK1_HUMAN
A:
[5-271]
-------
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
----------------
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
L
K
M
L
---
N
H
E
N
V
I
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
A
D
Y
S
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
85.97
100%
-106
- C3 -
-
2WMV
1
CHK1_HUMAN
A:
[7-270]
---------
E
D
W
D
L
V
---
Q
T
L
-----
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Blastp_CBE
85.77
97%
-102
- C3 -
-
5OQ7
1
CHK1_HUMAN
A:
[8-271]
----------
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
----------------
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
L
K
M
L
---
N
H
E
N
V
I
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
A
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
85.77
97%
-104
- C3 -
-
5OQ7
1
CHK1_HUMAN
B:
[8-270]
----------
D
W
D
L
V
---
Q
T
L
G
E
G
--
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
----------------
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
L
K
M
L
---
N
H
E
N
V
I
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
A
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Blastp_CBE
85.72
100%
-100
- C3 -
-
3PA5
4
CHK1_HUMAN
A:
[2-270]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
--
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
----
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
85.57
100%
-97
- C3 -
-
4FTR
3
CHK1_HUMAN
A:
[2-270]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
--
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
-----------------------------
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
85.39
99%
-98
- C3 -
-
5DLS
1
CHK1_HUMAN
A:
[6-270]
--------
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
85.39
98%
-91
- C3 -
-
2BRM
1
CHK1_HUMAN
A:
[7-274]
---------
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
----------------
C
--
P
--
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
85.17
99%
-96
- C3 -
-
6FCF
1
CHK1_HUMAN
A:
[9-269]
-----------
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-----------------------
N
---
I
K
--
K
-------
E
I
-
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
-
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
85.05
99%
-106
- C3 -
-
4FTN
4
CHK1_HUMAN
A:
[2-270]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
-----
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
------------------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
84.87
100%
-98
- C3 -
-
4JIK
1
CHK1_HUMAN
A:
[3-271]
---
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
----------------------------------
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
Blastp_CBE
84.70
100%
-91
- C3 -
-
3U9N
1
CHK1_HUMAN
A:
[6-270]
---------
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
--------------------------
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
84.67
100%
-100
- C3 -
-
4FTO
4
CHK1_HUMAN
A:
[2-270]
--
V
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
----
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
-----------------------------
E
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
----
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
84.53
100%
-101
- C3 -
-
2WMR
1
CHK1_HUMAN
A:
[7-270]
---------
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Blastp_CBE
84.48
100%
-108
- C3 -
-
2WMX
1
CHK1_HUMAN
A:
[7-269]
---------
E
D
W
D
L
V
---
Q
T
L
-----
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
84.08
100%
-102
- C3 -
-
3OT8
4
CHK1_HUMAN
A:
[4-270]
-------
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
---
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
-----
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Blastp_CBE
84.00
100%
-102
- C3 -
-
2YM6
6
CHK1_HUMAN
A:
[7-270]
---------
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
---------------------------
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
83.86
100%
-110
- C3 -
-
2WMU
1
CHK1_HUMAN
A:
[9-270]
-----------
W
D
L
V
---
Q
T
L
G
E
-----
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---------------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
83.83
100%
-108
- C3 -
-
2WMW
1
CHK1_HUMAN
A:
[7-269]
---------
E
D
W
D
L
V
---
Q
T
L
G
------
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
83.44
100%
-100
- C3 -
-
2YM4
4
CHK1_HUMAN
A:
[4-270]
---
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
------------------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
------
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Blastp_CBE
83.29
100%
-111
- C3 -
-
2WMT
1
CHK1_HUMAN
A:
[8-270]
----------
D
W
D
L
V
---
Q
T
L
G
-----
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
82.95
100%
-100
- C3 -
-
2YM3
6
CHK1_HUMAN
A:
[8-270]
----------
D
W
D
L
V
---
Q
T
L
G
-----
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---------------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Blastp_CBE
82.89
100%
-103
- C3 -
-
2YM8
10
CHK1_HUMAN
A:
[8-270]
----------
D
W
D
L
V
---
Q
T
L
G
-----
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
------------------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
82.81
100%
-106
- C3 -
-
2YM5
2
CHK1_HUMAN
A:
[8-270]
----------
D
W
D
L
V
---
Q
T
L
G
-----
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Blastp_CBE
82.77
100%
-101
- C3 -
-
2XF0
5
CHK1_HUMAN
A:
[4-270]
---
P
---
F
V
E
D
W
D
L
V
---
Q
T
L
-----
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---------------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
82.65
100%
-102
- C3 -
-
2XEZ
7
CHK1_HUMAN
A:
[7-270]
---------
E
D
W
D
L
V
---
Q
T
L
-----
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Blastp_CBE
82.44
100%
-103
- C3 -
-
2YM7
5
CHK1_HUMAN
A:
[7-271]
---------
E
D
W
D
L
V
---
Q
T
L
-----
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
------------------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
82.32
100%
-107
- C3 -
-
2WMS
1
CHK1_HUMAN
A:
[7-270]
---------
E
D
W
D
L
V
---
Q
T
L
-----
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
-------------------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
-----
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
81.22
100%
-102
- C3 -
-
2WMQ
1
CHK1_HUMAN
A:
[7-269]
---------
E
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---------------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
--------
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
74.04
99%
-60
- C3 -
-
2YDJ
1
CHK1_HUMAN
B:
[9-269]
-----------
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
-
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
74.00
99%
-58
- C3 -
-
2YDJ
1
CHK1_HUMAN
A:
[8-269]
----------
D
W
D
L
V
---
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
-
V
N
R
V
-
T
E
----
E
-
A
V
A
V
K
I
V
--
D
---
M
-----------------------
N
---
I
K
--
K
-------
E
I
C
I
N
K
M
L
---
N
H
E
N
V
V
K
F
-
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
-
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
-
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
----
E
R
---
D
---------
N
-----
L
--
K
I
S
D
F
G
L
A
T
V
F
R
--
Y
N
N
R
E
R
L
L
N
K
M
-
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
--
D
Q
---
P
--
S
D
--------
S
C
Q
E
-
Y
S
D
W
--
K
--
E
K
-
K
-
T
Y
-----
L
N
----
P
---
W
K
K
I
D
S
A
P
L
A
------
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
----
I
K
K
D
R
W
----
Y
N
----
K
P
L
K
K
G
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
175
Blastp_CBE
69.25
35%
-124
- C3 -
-
4UMQ
1
MELK_HUMAN
A:
[31-300]
-----------
Y
E
L
H
---
E
T
I
G
T
G
G
F
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
--
L
--
G
--
S
---
D
--
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
-------
D
D
--------
T
A
A
A
-
L
V
A
K
--
I
--
M
R
-
G
-
K
Y
-----
D
V
----
P
----
K
W
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
172
Blastp_CBE
68.74
34%
-115
- C3 -
-
4BKY
1
MELK_HUMAN
A:
[12-281]
-----------
Y
E
L
H
---
E
T
I
G
T
G
G
F
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
--
L
---------
D
--
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
C
A
------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
157
Blastp_CBE
68.63
34%
-122
- C3 -
-
5TWY
1
MELK_HUMAN
A:
[12-281]
-----------
Y
E
L
H
---
E
T
I
G
T
G
G
F
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
------------
D
--
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
155
Blastp_CBE
67.96
34%
-122
- C3 -
-
5TWZ
1
MELK_HUMAN
A:
[12-281]
-----------
Y
E
L
H
---
E
T
I
G
T
---
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
--
L
--
G
--
S
---
D
--
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
--------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
67.88
34%
-108
- C3 -
-
6GVX
3
MELK_HUMAN
A:
[15-291]
-----------
Y
E
L
H
---
E
T
I
G
T
--
F
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
------------
D
--
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
C
A
K
P
K
---
G
N
K
-------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
67.71
34%
-110
- C3 -
-
6GVX
2
MELK_HUMAN
B:
[15-284]
-----------
Y
E
L
H
---
E
T
I
G
T
G
--
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
--------
S
---
D
--
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
C
A
K
P
---------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
67.55
34%
-114
- C3 -
-
5IH9
1
MELK_HUMAN
A:
[10-279]
-----------
Y
E
L
H
---
E
T
I
G
T
G
G
F
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
---------------
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
C
A
K
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
177
Blastp_CBE
67.50
35%
-123
- C3 -
-
4UMT
2
MELK_HUMAN
A:
[31-300]
-----------
Y
E
L
H
---
E
T
I
G
T
G
G
F
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
--
L
--
G
--
S
---
D
--
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
-------
D
D
--------
T
A
A
A
-
L
V
A
K
--
I
--
M
R
-
G
-
K
Y
-----
D
V
----
P
----
K
W
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
67.49
34%
-115
- C3 -
-
5TWL
1
MELK_HUMAN
A:
[12-281]
-----------
Y
E
L
H
---
E
T
I
G
T
G
G
F
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
--
L
--
G
--
S
---
D
--
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
67.39
35%
-121
- C3 -
-
4UMU
1
MELK_HUMAN
A:
[31-300]
-----------
Y
E
L
H
---
E
T
I
G
T
G
G
F
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
--
L
--
G
--
S
---
D
--
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
-------
D
D
--------
T
A
A
A
-
L
V
A
K
--
I
--
M
R
-
G
-
K
Y
-----
D
V
----
P
----
K
W
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
67.30
34%
-122
- C3 -
-
5IH8
1
MELK_HUMAN
A:
[10-279]
-----------
Y
E
L
H
---
E
T
I
G
T
---
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
------------
D
--
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
C
A
K
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
67.13
34%
-120
- C3 -
-
4BKZ
1
MELK_HUMAN
A:
[12-281]
-----------
Y
E
L
H
---
E
T
I
G
T
G
--
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
--
L
------------
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
C
A
------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
161
Blastp_CBE
67.13
34%
-121
- C3 -
-
5IHA
1
MELK_HUMAN
A:
[10-279]
-----------
Y
E
L
H
---
E
T
I
G
----
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
--
L
----------------
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
C
A
K
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
152
Blastp_CBE
66.92
34%
-125
- C3 -
-
5TX3
2
MELK_HUMAN
A:
[15-284]
-----------
Y
E
L
H
---
E
T
I
G
T
---
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--------------------------
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
-------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
167
Blastp_CBE
66.81
34%
-114
- C3 -
-
5MAG
3
MELK_HUMAN
A:
[12-281]
-----------
Y
E
L
H
---
E
T
I
G
T
G
G
-
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
--
L
---------
D
--
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
C
A
K
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
--
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
169
Blastp_CBE
66.64
34%
-116
- C3 -
-
5M5A
1
MELK_HUMAN
A:
[12-281]
-----------
Y
E
L
H
---
E
T
I
G
T
G
G
F
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
--
L
--
G
--
S
---
D
--
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
C
A
------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
--
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
159
Blastp_CBE
66.61
34%
-114
- C3 -
-
5K00
1
MELK_HUMAN
A:
[10-279]
-----------
Y
E
L
H
---
E
T
I
G
T
G
--
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
--
L
--
G
--
S
---
D
--
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
C
A
K
P
----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
66.51
35%
-124
- C3 -
-
4UMR
1
MELK_HUMAN
A:
[31-300]
-----------
Y
E
L
H
---
E
T
I
G
T
G
G
F
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
--
L
--
G
--
S
---
D
--
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
-------
D
D
--------
T
A
A
A
-
L
V
A
K
--
I
--
M
R
-
G
-
K
Y
-----
D
V
----
P
----
K
W
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
66.47
34%
-122
- C3 -
-
5IHC
1
MELK_HUMAN
A:
[10-279]
-----------
Y
E
L
H
---
E
T
I
G
T
---
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
--
L
--
G
--
S
---
D
--
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
---------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
66.32
34%
-117
- C3 -
-
5MAH
2
MELK_HUMAN
A:
[12-281]
-----------
Y
E
L
H
---
E
T
I
G
T
G
G
F
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
--
L
--
G
--
S
---
D
--
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
C
A
K
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
--
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
66.28
34%
-123
- C3 -
-
5MAI
2
MELK_HUMAN
A:
[12-283]
-----------
Y
E
L
H
---
E
T
I
G
T
G
G
F
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
--
L
--
G
--
S
---
D
--
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
----------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
170
Blastp_CBE
66.27
34%
-116
- C3 -
-
4BL1
1
MELK_HUMAN
A:
[12-281]
-----------
Y
E
L
H
---
E
T
I
G
T
G
G
F
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
--
L
------------
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
C
A
K
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
168
Blastp_CBE
66.23
34%
-113
- C3 -
-
5MAF
2
MELK_HUMAN
A:
[12-281]
-----------
Y
E
L
H
---
E
T
I
G
T
G
G
F
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
--
L
---------
D
--
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
C
A
K
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
--
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
66.10
34%
-116
- C3 -
-
5TVT
1
MELK_HUMAN
A:
[12-281]
-----------
Y
E
L
H
---
E
T
I
G
T
G
G
F
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
--
L
--
G
--
S
---
D
--
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
C
A
K
----------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
156
Blastp_CBE
66.00
34%
-119
- C3 -
-
5TWY
1
MELK_HUMAN
B:
[12-281]
-----------
Y
E
L
H
---
E
T
I
G
T
---
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
---------------
D
--
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
C
--------------------
L
A
Y
A
A
P
E
L
I
Q
G
--
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
584
HHSearch
65.33
34%
-130
- C3 -
-
5TVT
1
MELK_HUMAN
A:
[6-269]
--
D
E
---
L
L
K
Y
Y
E
L
H
---
E
T
I
G
T
G
G
F
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
--
L
--
G
--
S
---
D
--
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
C
A
K
----------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
---
D
--
N
V
--------
M
-
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
---------
P
K
W
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
----
I
M
----
Q
D
Y
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
583
HHSearch
64.76
34%
-128
- C3 -
-
5K00
1
MELK_HUMAN
A:
[5-267]
---
E
---
L
L
K
Y
Y
E
L
H
---
E
T
I
G
T
G
--
A
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
N
--
T
--
L
--
G
--
S
---
D
--
L
--
P
R
---
I
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
C
A
K
P
----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
--
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
---
D
--
N
V
--------
M
-
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
---------
P
K
W
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
----
I
M
----
Q
D
Y
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
62.58
34%
-124
- C3 -
-
5TX3
2
MELK_HUMAN
B:
[15-284]
-----------
Y
E
L
H
---
E
T
I
G
-----
K
V
K
L
A
-
C
H
I
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
---
K
----------------------------
K
--
T
-------
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
Y
---
H
---------
K
-----
L
--
K
L
I
D
----------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
-----
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
D
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
----
L
L
N
H
P
W
IMQD
Y
N
----
Y
P
V
E
W
Q
S
K
N
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
61.24
33%
-64
- C3 -
-
2YIR
1
CHK2_HUMAN
A:
[10-277]
---------
D
E
Y
I
M
S
---
K
T
L
G
S
G
A
C
G
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
----------------------
L
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
299
Blastp_CBE
60.79
33%
-63
- C3 -
-
2YCF
1
CHK2_HUMAN
A:
[10-277]
---------
D
E
Y
I
M
S
---
K
T
L
G
S
G
A
C
G
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
-----------------------
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
301
Blastp_CBE
60.67
33%
-65
- C3 -
-
2YIT
1
CHK2_HUMAN
A:
[10-277]
---------
D
E
Y
I
M
S
---
K
T
L
G
S
G
A
C
G
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
----------------------
L
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
60.56
33%
-64
- C3 -
-
4BDK
4
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
G
----
G
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
-------------------
A
--
L
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
60.49
33%
-61
- C3 -
-
2XM9
1
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
G
S
---
G
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
----------------
P
--
A
--
L
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
60.46
33%
-65
- C3 -
-
4BDG
2
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
G
S
---
G
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
-----------------------
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
332
Blastp_CBE
60.35
33%
-62
- C3 -
-
2CN5
1
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
G
S
G
A
C
G
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
R
----------------------
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
60.23
33%
-73
- C3 -
-
4BDE
5
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
------
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
-------------------
A
--
L
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
60.16
33%
-67
- C3 -
-
2YCR
1
CHK2_HUMAN
A:
[10-277]
---------
D
E
Y
I
M
S
---
K
T
L
G
S
---
G
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
-----------------------
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
60.13
33%
-64
- C3 -
-
2W7X
3
CHK2_HUMAN
A:
[10-277]
---------
D
E
Y
I
M
S
---
K
T
L
G
S
G
A
-
G
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
-----------------------
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
305
Blastp_CBE
60.07
33%
-64
- C3 -
-
2YCQ
1
CHK2_HUMAN
A:
[10-277]
---------
D
E
Y
I
M
S
---
K
T
L
G
S
G
A
C
G
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
-----------------------
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
314
Blastp_CBE
59.75
33%
-61
- C3 -
-
4BDF
3
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
G
----
G
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
-----------------------
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
59.73
33%
-63
- C3 -
-
2XBJ
1
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
G
S
G
A
-
G
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
-------------------
A
--
L
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
59.52
33%
-58
- C3 -
-
4BDI
6
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
G
----
G
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
-------------------
A
--
L
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
317
Blastp_CBE
59.23
33%
-66
- C3 -
-
4BDC
2
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
G
S
----
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
-----------------------
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
59.17
33%
-62
- C3 -
-
2WTI
3
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
G
S
----
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
----------------
P
--
A
--
L
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
59.15
33%
-68
- C3 -
-
2YCS
1
CHK2_HUMAN
A:
[10-277]
---------
D
E
Y
I
M
S
---
K
T
L
G
S
---
G
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
-----------------------
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
323
Blastp_CBE
59.07
33%
-61
- C3 -
-
4A9R
2
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
------
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
----------------
P
--
A
--
L
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
59.06
33%
-64
- C3 -
-
2WTJ
5
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
G
S
----
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
----------------
P
--
A
--
L
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
59.02
33%
-66
- C3 -
-
4BDJ
1
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
G
-----
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
-----------------------
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
59.01
33%
-66
- C3 -
-
4BDB
10
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
------
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
----------------------
L
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
58.89
34%
-51
- C3 -
-
3IGO
8
?
A:
[20-297]
-------
F
A
E
R
Y
N
I
V
---
C
M
L
G
K
G
S
F
G
E
V
L
K
C
-
K
D
R
I
-
T
Q
----
Q
-
E
Y
A
V
K
V
I
--
N
---
K
A
--
S
--
A
--
K
--
N
---
K
--
T
--
S
T
---
I
L
--
R
-------
E
V
E
L
L
K
K
L
---
D
H
P
N
I
M
K
L
-
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
-
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
-
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
----
S
K
---
E
KDC------
D
-----
I
--
K
I
I
D
F
G
L
S
T
C
F
Q
--
Q
N
T
----------
T
A
Y
Y
I
A
P
E
V
L
----
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
-
F
--
Y
G
---
K
--
N
------------
E
-
Y
D
I
L
--
K
--
R
V
-
E
-
T
G
KYAFD
L
P
----
Q
---
W
R
T
I
S
D
D
A
K
D
------
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
----
C
L
E
H
P
W
----
I
Q
----
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
58.83
33%
-71
- C3 -
-
2W0J
1
CHK2_HUMAN
A:
[10-278]
---------
D
E
Y
I
M
S
---
K
T
L
G
S
---
G
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
-----------------------
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
58.76
33%
-67
- C3 -
-
4BDH
4
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
------
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
-----------------------
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
58.75
33%
-63
- C3 -
-
2YIQ
1
CHK2_HUMAN
A:
[10-277]
---------
D
E
Y
I
M
S
---
K
T
L
G
----
G
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
---------------------------
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
58.57
33%
-72
- C3 -
-
4BDD
3
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
------
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
-----------------------
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
322
Blastp_CBE
58.51
33%
-70
- C3 -
-
4A9S
1
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
------
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
----------------
P
--
A
--
L
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
58.47
38%
-41
- C3 -
-
5EAK
1
MARK2_HUMAN
A:
[12-269]
---
P
---
H
I
G
N
Y
R
L
L
---
K
T
I
G
K
G
N
F
A
K
V
K
L
A
-
R
H
I
L
-
T
G
----
K
-
E
V
A
V
K
I
I
--
D
---
K
T
--
Q
--
L
--
N
--
S
---
S
--
S
L-
Q
K
---
L
F
--
R
-------
E
V
R
I
M
K
V
L
---
N
H
P
N
I
V
K
L
-
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
-
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
-
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
----
A
D
---
M
---------
N
-----
I
--
K
I
A
D
F
G
F
S
----------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
--
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
-
F
--
D
-------
G
Q
--------
N
L
K
E
-
L
R
E
R
--
V
--
L
R
-
G
-
K
Y
-----
R
I
----
P
---
F
-
Y
M
S
T
D
C
E
N
------
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
----
I
M
K
D
R
W
----
M
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
58.46
32%
-50
- C3 -
-
3F3Z
5
?
A:
[11-269]
-----------
Y
T
L
E
---
N
T
I
G
R
G
S
W
G
E
V
K
I
A
-
V
Q
K
G
-
T
R
----
I
-
R
R
A
A
K
K
I
--
P
----
K
--
Y
--
F
--
V
--
E
---
D
--
V
--
D
R
---
F
K
--
Q
-------
E
I
E
I
M
K
S
L
---
D
H
P
N
I
I
R
L
-
Y
E
T
F
E
D
N
T
D
I
Y
L
V
M
E
L
C
T
G
G
E
L
F
E
R
V
-
V
H
K
R
V
F
R
E
S
D
A
A
R
I
M
K
D
-
V
L
S
A
V
A
Y
C
H
K
L
N
V
A
H
R
D
L
K
P
E
N
F
L
---
F
LT-
D
----
S
P
---
D
---------
S
P----
L
--
K
L
I
D
F
G
L
A
A
R
F
K
--
P
G
---
K
M
M
R
T
K
V
G
T
P
Y
Y
V
S
P
Q
V
L
E
----
G
L
Y
G
P
E
C
D
E
W
S
A
G
V
M
M
Y
V
L
L
C
G
Y
P
P
-
F
--
S
A
---
P
--
T
D
--------
S
--
E
-
V
M
L
K
--
I
--
R
E
-
G
-
T
F
-----
T
F
----
P
EKD
W
L
N
V
S
P
Q
A
E
S
------
L
I
R
R
L
L
T
K
S
P
K
Q
R
I
-----
T
S
L
Q
----
A
L
E
H
E
W
----
F
E
----
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
285
Blastp_CBE
58.24
35%
-31
- C3 -
-
5T6I
1
?
A:
[65-359]
-------
F
S
D
R
Y
K
G
Q
---
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
K--
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KA-------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
283
Blastp_CBE
58.23
35%
-39
- C3 -
-
3HX4
3
?
A:
[48-308]
-------
F
S
D
R
Y
K
G
Q
---
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
K---------------
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
58.15
33%
-57
- C3 -
-
4A9T
4
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
G
S
---
G
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
----------------
P
--
A
--
L
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
58.11
38%
-38
- C3 -
-
5KZ8
1
MARK2_HUMAN
A:
[30-287]
---
P
---
H
I
G
N
Y
R
L
L
---
K
T
I
G
K
G
N
F
A
K
V
K
L
A
-
R
H
I
L
-
T
G
----
K
-
E
V
A
V
K
I
I
--
D
---
K
T
--
Q
--
L
--
N
--
S
---
S
--
S
L-
Q
K
---
L
F
--
R
-------
E
V
R
I
M
K
V
L
---
N
H
P
N
I
V
K
L
-
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
-
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
-
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
----
A
D
---
M
---------
N
-----
I
--
K
I
A
D
F
G
-------------------
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
--
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
-
F
--
D
-------
G
Q
--------
N
L
K
E
-
L
R
E
R
--
V
--
L
R
-
G
-
K
Y
-----
R
I
----
P
---
F
-
Y
M
S
T
D
C
E
N
------
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
----
I
M
K
D
R
W
----
M
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
58.00
33%
-64
- C3 -
-
6T6F
1
?
A:
[16-286]
-----------
F
E
F
K
---
E
T
L
G
T
G
A
F
S
E
V
V
L
A
-
E
E
K
A
-
T
G
----
K
-
L
F
A
V
K
C
I
--
P
---
K
K
--
A
--
L
--
K
--
G
---
K
--
E
--
S
S
---
I
E
--
N
-------
E
I
A
V
L
R
K
I
---
K
H
E
N
I
V
A
L
-
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
-
V
E
K
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
-
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ
D
----
E
E
---
S
---------
K
-----
I
--
M
I
S
D
F
G
L
S
--------------------
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
-
F
--
Y
D
---
E
--
N
D
--------
S
K
L
F
-
E
Q
I
L
--
K
--
A
E
-
Y
-
E
F
-----
D
S
----
P
Y--
W
D
D
I
S
D
S
A
K
D
------
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
-----
T
C
E
Q
----
A
A
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
57.91
33%
-62
- C3 -
-
4BDA
8
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
G
S
----
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
-----------------------
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
57.85
33%
-62
- C3 -
-
6T6F
1
?
B:
[16-286]
-----------
F
E
F
K
---
E
T
L
G
T
G
A
F
S
E
V
V
L
A
-
E
E
K
A
-
T
G
----
K
-
L
F
A
V
K
C
I
--
P
---
K
K
--
A
--
L
--
K
--
G
---
K
--
E
--
S
S
---
I
E
--
N
-------
E
I
A
V
L
R
K
I
---
K
H
E
N
I
V
A
L
-
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
-
V
E
K
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
-
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ
D
----
E
E
---
S
---------
K
-----
I
--
M
I
S
D
F
G
----------------------
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
-
F
--
Y
D
---
E
--
N
D
--------
S
K
L
F
-
E
Q
I
L
--
K
--
A
E
-
Y
-
E
F
-----
D
S
----
P
Y--
W
D
D
I
S
D
S
A
K
D
------
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
-----
T
C
E
Q
----
A
A
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
57.69
33%
-62
- C3 -
-
2WTD
4
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
G
S
----
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
----------------
P
--
A
--
L
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
57.62
33%
-65
- C3 -
-
4A9U
10
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
G
S
----
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
------------
D
---
P
--
A
--
L
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
57.60
33%
-61
- C3 -
-
2XK9
1
CHK2_HUMAN
A:
[9-276]
---------
D
E
Y
I
M
S
---
K
T
L
G
S
G
A
-
G
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
-----------------------
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
57.23
38%
-38
- C3 -
-
5EAK
1
MARK2_HUMAN
B:
[15-269]
---------
G
N
Y
R
L
L
---
K
T
I
G
K
G
N
F
A
K
V
K
L
A
-
R
H
I
L
-
T
G
----
K
-
E
V
A
V
K
I
I
--
D
---
K
T
--
Q
--
L
--
N
--
S
---
S
--
S
L-
Q
K
---
L
F
--
R
-------
E
V
R
I
M
K
V
L
---
N
H
P
N
I
V
K
L
-
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
-
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
-
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
----
A
D
---
M
---------
N
-----
I
--
K
I
A
D
F
G
------------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
--
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
-
F
--
D
-------
G
Q
--------
N
L
K
E
-
L
R
E
R
--
V
--
L
R
-
G
-
K
Y
-----
R
I
----
P
---
F
-
Y
M
S
T
D
C
E
N
------
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
----
I
M
K
D
R
W
----
M
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
57.14
33%
-73
- C3 -
-
2JC6
1
KCC1D_HUMAN
A:
[24-279]
-----------
F
E
F
K
---
E
T
L
G
T
G
A
F
S
E
V
V
L
A
-
E
E
K
A
-
T
G
----
K
-
L
F
A
V
K
C
I
--
P
---
K
K
--
A
------------------
S
S
---
I
E
--
N
-------
E
I
A
V
L
R
K
I
---
K
H
E
N
I
V
A
L
-
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
-
V
E
K
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
-
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ
D
----
E
E
---
S
---------
K
-----
I
--
M
I
S
-------------------------
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
-
F
--
Y
D
---
E
--
N
D
--------
S
K
L
F
-
E
Q
I
L
--
K
--
A
E
-
Y
-
E
F
-----
D
S
----
P
Y--
W
D
D
I
S
D
S
A
K
D
------
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
-----
T
C
E
Q
----
A
A
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
57.08
32%
-28
- C3 -
-
2V7O
3
KCC2G_HUMAN
A:
[29-290]
-------
F
T
D
D
Y
Q
L
F
---
E
E
L
G
K
G
-
F
S
V
V
R
R
C
-
V
K
K
T
-
P
T
----
Q
-
E
Y
A
A
K
I
I
--
N
---
T
K
--
K
L-
S
--
A
--
R
---
D
--
H
--
Q
K
---
L
E
--
R
-------
E
A
R
I
C
R
L
L
---
K
H
P
N
I
V
R
L
-
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
-
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
H
Q
-
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
----
S
K
CKG
A
---------
A
-----
V
--
K
L
A
D
F
G
L
A
--
I
E
--
V
Q
G
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-
R
--
K
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
-------
D
--------
Q
H
K
L
-
Y
Q
Q
I
--
K
---
A
-
G
-
A
Y
-----
D
F
----
P
SPE
W
D
T
V
T
P
E
A
K
N
------
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
-----
T
A
D
Q
----
A
L
K
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
349
Blastp_CBE
56.82
31%
-32
- C3 -
-
3BHH
1
KCC2B_HUMAN
A:
[2-263]
-------
M
T
D
E
Y
Q
L
Y
---
E
D
I
G
----
S
V
V
R
R
C
-
V
K
L
C
-
T
G
----
H
-
E
Y
A
A
K
I
I
--
N
---
T
K
--
K
L-
S
--
A
--
R
---
D
--
H
--
Q
K
---
L
E
--
R
-------
E
A
R
I
C
R
L
L
---
K
H
S
N
I
V
R
L
-
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
-
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
-
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
----
S
K
CKG
A
---------
A
-----
V
--
K
L
A
D
F
G
L
A
--
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-
R
--
K
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
-------
D
--------
Q
H
K
L
-
Y
Q
Q
I
--
K
---
A
-
G
-
A
Y
-----
D
F
----
P
SPE
W
D
T
V
T
P
E
A
K
N
------
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
-----
T
A
H
E
----
A
L
K
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
280
Blastp_CBE
56.69
35%
-11
- C3 -
-
4IH8
1
?
A:
[47-335]
-------
F
S
D
R
Y
K
G
Q
---
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
---------
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
382
Blastp_CBE
56.60
32%
-30
- C3 -
-
2VN9
1
KCC2D_HUMAN
B:
[2-263]
-------
M
T
D
E
Y
Q
L
F
---
E
E
L
G
K
G
A
F
S
V
V
R
R
C
-
M
K
I
P
-
T
G
----
Q
-
E
Y
A
A
K
I
I
--
N
---
T
K
--
K
L-
S
--
A
--
R
---
D
--
H
--
Q
K
---
L
E
--
R
-------
E
A
R
I
C
R
L
L
---
K
H
P
N
I
V
R
L
-
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
-
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
-
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
----
S
K
---
S
---------
K
GAA--
V
--
K
L
A
D
F
G
L
A
--
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-
R
--
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
-------
D
--------
Q
H
R
L
-
Y
Q
Q
I
--
K
---
A
-
G
-
A
Y
-----
D
F
----
P
SPE
W
D
T
V
T
P
E
A
K
D
------
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
----
A
L
K
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
56.44
32%
-25
- C3 -
-
6AYW
2
KCC2D_HUMAN
B:
[11-272]
-------
F
T
D
E
Y
Q
L
F
---
E
E
L
G
K
G
A
F
S
V
V
R
R
C
-
M
K
I
P
-
T
G
----
Q
-
E
Y
A
A
K
I
I
--
N
---
T
K
--
K
L-
S
--
A
--
R
---
D
--
H
--
Q
K
---
L
E
--
R
-------
E
A
R
I
C
R
L
L
---
K
H
P
N
I
V
R
L
-
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
-
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
-
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
----
S
K
---
S
---------
K
GAA--
V
--
K
L
A
D
F
G
L
A
--
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-
R
--
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
-------
D
--------
Q
H
R
L
-
Y
Q
Q
I
--
K
---
A
-
G
-
A
Y
-----
D
F
----
P
SPE
W
D
T
V
T
P
E
A
K
D
------
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
----
A
L
K
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
56.20
33%
-57
- C3 -
-
2WTC
1
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
G
S
----
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
----------------
P
--
A
--
L
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
56.19
33%
-73
- C3 -
-
2CN8
1
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
G
S
----
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
I
--
S
---
K
-----------------------
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
--
P
T
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
-------------
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
56.13
32%
-26
- C3 -
-
5VLO
2
KCC2D_HUMAN
B:
[11-272]
-------
F
T
D
E
Y
Q
L
F
---
E
E
L
G
K
G
A
F
S
V
V
R
R
C
-
M
K
I
P
-
T
G
----
Q
-
E
Y
A
A
K
I
I
--
N
---
T
K
--
K
L-
S
--
A
--
R
---
D
--
H
--
Q
K
---
L
E
--
R
-------
E
A
R
I
C
R
L
L
---
K
H
P
N
I
V
R
L
-
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
-
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
-
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
----
S
K
---
S
---------
K
GAA--
V
--
K
L
A
D
F
G
L
A
--
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-
R
--
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
-------
D
--------
Q
H
R
L
-
Y
Q
Q
I
--
K
---
A
-
G
-
A
Y
-----
D
F
----
P
SPE
W
D
T
V
T
P
E
A
K
D
------
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
----
A
L
K
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
56.10
35%
-9
- C3 -
-
5T6K
1
?
A:
[65-356]
-------
F
S
D
R
Y
K
G
Q
---
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
56.09
32%
-26
- C3 -
-
6AYW
2
KCC2D_HUMAN
A:
[11-272]
-------
F
T
D
E
Y
Q
L
F
---
E
E
L
G
K
G
A
F
S
V
V
R
R
C
-
M
K
I
P
-
T
G
----
Q
-
E
Y
A
A
K
I
I
--
N
---
T
K
--
K
L-
S
--
A
--
R
---
D
--
H
--
Q
K
---
L
E
--
R
-------
E
A
R
I
C
R
L
L
---
K
H
P
N
I
V
R
L
-
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
-
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
-
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
----
S
K
---
S
---------
K
GAA--
V
--
K
L
A
D
F
G
L
A
--
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-
R
--
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
-------
D
--------
Q
H
R
L
-
Y
Q
Q
I
--
K
---
A
-
G
-
A
Y
-----
D
F
----
P
SPE
W
D
T
V
T
P
E
A
K
D
------
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
----
A
L
K
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
56.08
32%
-31
- C3 -
-
3SOA
1
KCC2A_HUMAN
A:
[9-270]
-------
F
T
E
E
Y
Q
L
F
---
E
E
L
G
K
G
--
S
V
V
R
R
C
-
V
K
V
L
-
A
G
----
Q
-
E
Y
A
A
M
I
I
--
N
---
T
K
--
K
L-
S
--
A
--
R
---
D
--
H
--
Q
K
---
L
E
--
R
-------
E
A
R
I
C
R
L
L
---
K
H
P
N
I
V
R
L
-
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
-
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
-
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
---
L
---
A
----
S
K
LKG
A
---------
A
-----
V
--
K
L
A
D
F
G
L
A
--
I
E
--
V
E
G
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-
R
--
K
D
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
-------
D
--------
Q
H
R
L
-
Y
Q
Q
I
--
K
---
A
-
G
-
A
Y
-----
D
F
----
P
SPE
W
D
T
V
T
P
E
A
K
D
------
L
I
N
K
M
L
T
I
N
P
S
K
R
I
-----
T
A
A
E
----
A
L
K
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
56.07
33%
-72
- C3 -
-
2XM8
1
CHK2_HUMAN
A:
[16-283]
---------
D
E
Y
I
M
S
---
K
T
L
G
-----
E
V
K
L
A
-
F
E
R
K
-
T
C
----
K
-
K
V
A
I
K
I
-------------------------------
N
---
V
E
--
T
-------
E
I
E
I
L
K
K
L
---
N
H
P
C
I
I
K
I
-
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
-
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
-
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
---
S
----
S
Q
---
E
---------
E
DCL--
I
--
K
I
T
D
F
G
H
S
K
I
L
-------
T
S
L
M
R
T
L
C
G
---
Y
L
A
P
E
V
L
V
S
VG
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
--
S
E
---
H
--
R
T
--------
Q
V
S
L
-
K
D
Q
I
--
T
--
S
G
-
K
-
Y
N
-----
F
I
----
P
EV-
W
A
E
V
S
E
K
A
L
D
------
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
T
E
E
----
A
L
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
55.88
34%
-27
- C3 -
-
4Y5Q
1
?
A:
[20-302]
-------
F
A
E
R
Y
N
I
V
---
C
M
L
G
K
G
S
F
G
E
V
L
K
C
-
K
D
R
I
-
T
Q
----
Q
-
E
Y
A
V
K
V
I
--
N
---
K
A
--
S
--
A
--
K
--
N
---
K
D-
T
--
S
T
---
I
L
--
R
-------
E
V
E
L
L
K
K
L
---
D
H
P
N
I
M
K
L
-
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
-
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
-
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
----
S
K
---
E
KDC------
D
-----
I
--
K
I
I
D
F
G
L
S
T
C
F
Q
--
Q
N
T
------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
----
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
-
F
--
Y
G
---
K
--
N
------------
E
-
Y
D
I
L
--
K
--
R
V
-
E
-
T
G
KYAFD
L
P
----
Q
---
W
R
T
I
S
D
D
A
K
D
------
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
----
C
L
E
H
P
W
----
I
Q
----
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
55.83
35%
-6
- C3 -
-
5JMS
2
?
A:
[65-342]
-------
F
S
D
R
Y
K
G
Q
---
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
55.79
35%
-7
- C3 -
-
5JN2
1
?
A:
[65-340]
-------
F
S
D
R
Y
K
G
Q
---
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
55.73
35%
-12
- C3 -
-
3KU2
1
?
A:
[47-314]
-------
F
S
D
R
Y
K
G
Q
---
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
55.72
33%
-71
- C3 -
-
2JC6
1
KCC1D_HUMAN
C:
[24-279]
-----------
F
E
F
K
---
E
T
L
G
T
G
A
F
S
E
V
V
L
A
-
E
E
K
A
-
T
G
----
K
-
L
F
A
V
K
C
I
--
P
---
K
K
--
A
-------------------
S
---
I
E
--
N
-------
E
I
A
V
L
R
K
I
---
K
H
E
N
I
V
A
L
-
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
-
V
E
K
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
-
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ
D
----
E
E
---
S
---------
K
-----
I
--
M
I
S
-------------------------
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
-
F
--
Y
D
---
E
--
N
D
--------
S
K
L
F
-
E
Q
I
L
--
K
--
A
E
-
Y
-
E
F
-----
D
S
----
P
Y--
W
D
D
I
S
D
S
A
K
D
------
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
-----
T
C
E
Q
----
A
A
R
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
55.60
32%
-44
- C3 -
-
2JAM
3
KCC1G_HUMAN
B:
[13-264]
-------------
F
M
---
E
V
L
G
S
G
A
F
S
E
V
F
L
V
-
K
Q
R
L
-
T
G
----
K
-
L
F
A
L
K
C
I
--
K
---
K
----------------------
S
S
---
L
E
--
N
-------
E
I
A
V
L
K
K
I
---
K
H
E
N
I
V
T
L
-
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
-
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
-
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
LTP
E
----
E
N
---
S
---------
K
-----
I
--
M
I
T
D
F
G
L
S
K
M
------
E
Q
N
G
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
-
F
--
Y
E
---
E
--
T
E
--------
S
-
K
L
-
F
E
K
I
--
K
--
E
G
Y
Y
-
E
F
-----
E
S
----
P
F--
W
D
D
I
S
E
S
A
K
D
------
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
-----
T
C
E
K
----
A
L
S
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
335
Blastp_CBE
55.59
34%
-52
- C3 -
-
4FG8
1
KCC1A_HUMAN
B:
[20-275]
-----------
Y
D
F
R
---
D
V
L
G
T
G
A
F
S
E
V
I
L
A
-
E
D
K
R
-
T
Q
----
K
-
L
V
A
I
K
C
I
------
A
K
------------------------------
N
-------
E
I
A
V
L
H
K
I
---
K
H
P
N
I
V
A
L
-
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
-
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
-
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
----
E
D
---
S
---------
K
-----
I
--
M
I
S
D
F
G
------------
G
S
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
-
F
--
Y
D
---
E
--
N
D
--------
A
K
L
F
-
E
Q
I
L
--
K
--
A
E
-
Y
-
E
F
-----
D
S
----
P
Y--
W
D
D
I
S
D
S
A
K
D
------
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
----
A
L
Q
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
240
Blastp_CBE
55.55
34%
-29
- C3 -
-
2WEI
1
?
A:
[20-282]
-------
F
A
E
R
Y
N
I
V
---
C
M
L
G
K
G
S
F
G
E
V
L
K
C
-
K
D
R
I
-
T
Q
----
Q
-
E
Y
A
V
K
V
I
--
N
---
K
A
--
S
--
A
--
K
--
N
---
K
D-
T
--
S
T
---
I
L
--
R
-------
E
V
E
L
L
K
K
L
---
D
H
P
N
I
M
K
L
-
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
-
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
-
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
----
S
K
---
E
KDC------
D
-----
I
--
K
I
I
D
F
G
L
S
T
C
F
Q
--
Q
N
T
K
---
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
----
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
-
F
--
Y
G
---
K
--
N
------------
E
-
Y
D
I
L
--
K
--
R
V
-
E
-
T
G
KYAFD
L
P
----
Q
---
W
R
T
I
S
D
D
A
K
D
------
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
----
C
L
E
H
P
W
----
I
Q
----
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
55.55
38%
-31
- C3 -
-
5KZ8
1
MARK2_HUMAN
B:
[30-287]
---
P
---
H
I
G
N
Y
R
L
L
---
K
T
I
G
K
G
N
F
A
K
V
K
L
A
-
R
H
I
L
-
T
G
----
K
-
E
V
A
V
K
I
I
--
D
---
K
T
--
Q
--
L
--
N
--
S
---
S
--
S
L-
Q
K
---
L
F
--
R
-------
E
V
R
I
M
K
V
L
---
N
H
P
N
I
V
K
L
-
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
-
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
-
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
----
A
D
---
M
---------
N
-----
I
--
K
I
A
D
F
---------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
--
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
-
F
--
D
-------
G
Q
--------
N
L
K
E
-
L
R
E
R
--
V
--
L
R
-
G
-
K
Y
-----
R
I
----
P
---
F
-
Y
M
S
T
D
C
E
N
------
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
----
I
M
K
D
R
W
----
M
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
55.51
34%
-67
- C3 -
-
4FG9
1
KCC1A_HUMAN
A:
[20-275]
-----------
Y
D
F
R
---
D
V
L
G
T
G
A
F
S
E
V
I
L
A
-
E
D
K
R
-
T
Q
----
K
-
L
V
A
I
K
C
I
------
A
K
--
E
------------------------
E
--
N
-------
E
I
A
V
L
H
K
I
---
K
H
P
N
I
V
A
L
-
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
-
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
-
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
----
E
D
---
S
---------
K
-----
I
--
M
I
S
D
F
-----------------------
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
-
F
--
Y
D
---
E
--
N
D
--------
A
K
L
F
-
E
Q
I
L
--
K
--
A
E
-
Y
-
E
F
-----
D
S
----
P
Y--
W
D
D
I
S
D
S
A
K
D
------
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
----
A
L
Q
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
55.44
35%
-20
- C3 -
-
4CQG
1
MELK_MOUSE
A:
[11-278]
-----------
Y
E
L
Y
---
E
T
I
G
T
G
G
F
A
K
V
K
L
A
-
C
H
V
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
----
K
--
N
--
A
--
L
GS
D
---
L
--
P
---
R
---
V
K
--
T
-------
E
I
D
A
L
K
S
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
N
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
C
A
K
---------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
-------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
E
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
R
N
----
L
L
N
H
P
W
VMQD
Y
S
----
C
P
V
E
W
Q
S
K
T
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
336
Blastp_CBE
55.37
34%
-65
- C3 -
-
4FG8
1
KCC1A_HUMAN
A:
[20-275]
-----------
Y
D
F
R
---
D
V
L
G
T
G
A
F
S
E
V
I
L
A
-
E
D
K
R
-
T
Q
----
K
-
L
V
A
I
K
C
I
------
A
K
---------------------------
E
--
N
-------
E
I
A
V
L
H
K
I
---
K
H
P
N
I
V
A
L
-
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
-
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
-
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
----
E
D
---
S
---------
K
-----
I
--
M
I
S
D
F
----------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
-
F
--
Y
D
---
E
--
N
D
--------
A
K
L
F
-
E
Q
I
L
--
K
--
A
E
-
Y
-
E
F
-----
D
S
----
P
Y--
W
D
D
I
S
D
S
A
K
D
------
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
----
A
L
Q
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
300
Blastp_CBE
55.36
34%
-55
- C3 -
-
4FG7
1
KCC1A_HUMAN
A:
[20-275]
-----------
Y
D
F
R
---
D
V
L
G
T
G
A
F
S
E
V
I
L
A
-
E
D
K
R
-
T
Q
----
K
-
L
V
A
I
K
C
I
------
A
-----------------------
S
---
M
E
--
N
-------
E
I
A
V
L
H
K
I
---
K
H
P
N
I
V
A
L
-
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
-
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
-
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
----
E
D
---
S
---------
K
-----
I
--
M
I
S
D
F
G
L
S
---
K
--
M
E
D
P
--------
G
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
---
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
-
F
--
Y
D
---
E
--
N
D
--------
A
K
L
F
-
E
Q
I
L
--
K
--
A
E
-
Y
-
E
F
-----
D
S
----
P
Y--
W
D
D
I
S
D
S
A
K
D
------
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
----
A
L
Q
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
55.34
32%
-29
- C3 -
-
5VLO
2
KCC2D_HUMAN
A:
[11-272]
-------
F
T
D
E
Y
Q
L
F
---
E
E
L
G
---
F
S
V
V
R
R
C
-
M
K
I
P
-
T
G
----
Q
-
E
Y
A
A
K
I
I
--
N
---
T
K
--
K
L-
S
--
A
--
R
---
D
--
H
--
Q
K
---
L
E
--
R
-------
E
A
R
I
C
R
L
L
---
K
H
P
N
I
V
R
L
-
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
-
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
-
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
----
S
K
---
S
---------
K
GAA--
V
--
K
L
A
D
F
G
L
A
--
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-
R
--
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
-------
D
--------
Q
H
R
L
-
Y
Q
Q
I
--
K
---
A
-
G
-
A
Y
-----
D
F
----
P
SPE
W
D
T
V
T
P
E
A
K
D
------
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
----
A
L
K
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
55.32
32%
-28
- C3 -
-
6BAB
2
KCC2D_MOUSE
A:
[12-272]
--------
T
D
E
Y
Q
L
F
---
E
E
L
G
K
G
A
F
S
V
V
R
R
C
-
M
K
I
P
-
T
G
----
Q
-
E
Y
A
A
K
I
I
--
N
---
T
K
--
K
L-
S
--
A
--
R
---
D
--
H
--
Q
K
---
L
E
--
R
-------
E
A
R
I
C
R
L
L
---
K
H
P
N
I
V
R
L
-
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
-
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
-
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
----
S
K
---
S
---------
K
GAA--
V
--
K
L
A
D
F
G
L
A
--
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-
R
--
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
-------
D
--------
Q
H
R
L
-
Y
Q
Q
I
--
K
---
A
-
G
-
A
Y
-----
D
F
----
P
SPE
W
D
T
V
T
P
E
A
K
D
------
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
----
A
L
K
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
55.24
35%
-17
- C3 -
-
4IEB
1
?
A:
[47-308]
-------
F
S
D
R
Y
K
G
Q
---
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
---------
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
M
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE---
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
55.02
35%
-11
- C3 -
-
5T6A
1
?
A:
[65-356]
-------
F
S
D
R
Y
K
G
Q
---
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
54.92
32%
-24
- C3 -
-
2WEL
7
KCC2D_HUMAN
A:
[2-267]
-------
M
T
D
E
Y
Q
L
F
---
E
E
L
G
K
G
A
F
S
V
V
R
R
C
-
M
K
I
P
-
T
G
----
Q
-
E
Y
A
A
K
I
I
--
N
---
T
K
--
K
L-
S
--
A
--
R
---
D
--
H
--
Q
K
---
L
E
--
R
-------
E
A
R
I
C
R
L
L
---
K
H
P
N
I
V
R
L
-
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
-
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
-
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
----
S
K
---
S
---------
K
GAA--
V
--
K
L
A
D
F
G
L
A
--
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-
R
--
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
-------
D
--------
Q
H
R
L
-
Y
Q
Q
I
--
K
---
A
-
G
-
A
Y
-----
D
F
----
P
SPE
W
D
T
V
T
P
E
A
K
D
------
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
----
A
L
K
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
54.91
33%
17
* C3 *
-
5H9B
2
KCC2A_DROME
A:
[9-277]
----CTR
F
S
D
N
Y
D
I
K
---
E
E
L
G
K
G
A
F
S
I
V
K
R
C
-
V
Q
K
S
-
T
G
----
F
-
E
F
A
A
K
I
I
--
N
---
T
K
--
K
LT
A
--
R
--
D
---
F
-----
Q
K
---
L
E
--
R
-------
E
A
R
I
C
R
K
L
---
H
H
P
N
I
V
R
L
-
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
-
V
A
R
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
-
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
----
S
K
---
A
---------
K
GAA--
V
--
K
L
A
D
F
G
L
A
I
E
V
Q
--
G
D
H
Q
A
W
F
--
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
---
K
E
P
Y
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
-------
D
--------
Q
H
R
L
-
Y
S
Q
I
--
K
--
A
G
-
A
Y
D
Y
-----
P
S
----
P
E--
W
D
T
V
T
P
E
A
K
N
------
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
A
A
E
----
A
L
K
H
P
W
----
I
-----------
C
Q
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
54.81
33%
16
- C3 -
-
5FG8
3
KCC2A_DROME
A:
[9-277]
----CTR
F
S
D
N
Y
D
I
K
---
E
E
L
G
K
G
A
F
S
I
V
K
R
C
-
V
Q
K
S
-
T
G
----
F
-
E
F
A
A
K
I
I
--
N
---
T
K
--
K
LT
A
--
R
--
D
---
F
-----
Q
K
---
L
E
--
R
-------
E
A
R
I
C
R
K
L
---
H
H
P
N
I
V
R
L
-
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
-
V
A
R
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
-
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
----
S
K
---
A
---------
K
GAA--
V
--
K
L
A
D
F
G
L
A
I
E
V
Q
--
G
D
H
Q
A
W
F
--
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
---
K
E
P
Y
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
-------
D
--------
Q
H
R
L
-
Y
S
Q
I
--
K
--
A
G
-
A
Y
D
Y
-----
P
S
----
P
E--
W
D
T
V
T
P
E
A
K
N
------
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
A
A
E
----
A
L
K
H
P
W
----
I
-----------
C
Q
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
54.80
34%
-63
- C3 -
-
4FG9
1
KCC1A_HUMAN
B:
[20-275]
-----------
Y
D
F
R
---
D
V
L
G
T
G
A
F
S
E
V
I
L
A
-
E
D
K
R
-
T
Q
----
K
-
L
V
A
I
K
C
I
------
A
K
--------------------------------------
E
I
A
V
L
H
K
I
---
K
H
P
N
I
V
A
L
-
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
-
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
-
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
----
E
D
---
S
---------
K
-----
I
--
M
I
S
D
F
---------------
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
-
F
--
Y
D
---
E
--
N
D
--------
A
K
L
F
-
E
Q
I
L
--
K
--
A
E
-
Y
-
E
F
-----
D
S
----
P
Y--
W
D
D
I
S
D
S
A
K
D
------
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
----
A
L
Q
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
54.72
32%
-46
- C3 -
-
2JAM
3
KCC1G_HUMAN
A:
[13-264]
-------------
F
M
---
E
V
L
G
S
G
A
F
S
E
V
F
L
V
-
K
Q
R
L
-
T
G
----
K
-
L
F
A
L
K
C
I
--
K
---
K
----------------------
S
S
---
L
E
--
N
-------
E
I
A
V
L
K
K
I
---
K
H
E
N
I
V
T
L
-
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
-
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
-
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
LTP
E
----
E
N
---
S
---------
K
-----
I
--
M
I
T
D
F
G
L
S
K
M
------
E
Q
N
G
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
-
F
--
Y
E
---
E
--
T
E
--------
S
-
K
L
-
F
E
K
I
--
K
--
E
G
Y
Y
-
E
F
-----
E
S
----
P
F--
W
D
D
I
S
E
S
A
K
D
------
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
-----
T
C
E
K
----
A
L
S
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
54.64
32%
-28
- C3 -
-
6BAB
2
KCC2D_MOUSE
C:
[14-272]
----------
E
Y
Q
L
F
---
E
E
L
G
K
G
A
F
S
V
V
R
R
C
-
M
K
---------
Q
-
E
Y
A
A
K
I
I
--
N
---
T
K
--
K
L-
S
--
A
--
R
---
D
--
H
--
Q
K
---
L
E
--
R
-------
E
A
R
I
C
R
L
L
---
K
H
P
N
I
V
R
L
-
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
-
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
-
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
----
S
K
---
S
---------
K
GAA--
V
--
K
L
A
D
F
G
L
A
--
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-
R
--
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
-------
D
--------
Q
H
R
L
-
Y
Q
Q
I
--
K
---
A
-
G
-
A
Y
-----
D
F
----
P
SPE
W
D
T
V
T
P
E
A
K
D
------
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
----
A
L
K
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
281
Blastp_CBE
54.64
35%
-6
- C3 -
-
4IFG
1
?
A:
[47-319]
-------
F
S
D
R
Y
K
G
Q
---
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
279
Blastp_CBE
54.61
35%
-2
- C3 -
-
4IHP
1
?
A:
[47-317]
-------
F
S
D
R
Y
K
G
Q
---
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
54.55
32%
-21
- C3 -
-
6BAB
2
KCC2D_MOUSE
B:
[14-272]
----------
E
Y
Q
L
F
---
E
E
L
G
----
S
V
V
R
R
C
-
M
K
I
P
-
T
G
----
Q
-
E
Y
A
A
K
I
I
--
N
---
T
K
--
K
L-
S
--
A
--
R
---
D
--
H
--
Q
K
---
L
E
--
R
-------
E
A
R
I
C
R
L
L
---
K
H
P
N
I
V
R
L
-
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
-
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
-
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
----
S
K
---
S
---------
K
GAA--
V
--
K
L
A
D
F
G
L
A
--
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-
R
--
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
-------
D
--------
Q
H
R
L
-
Y
Q
Q
I
--
K
---
A
-
G
-
A
Y
-----
D
F
----
P
SPE
W
D
T
V
T
P
E
A
K
D
------
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
----
A
L
K
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
54.51
34%
-30
- C3 -
-
3NCG
1
?
A:
[20-319]
-------
F
A
E
R
Y
N
I
V
---
C
M
L
G
K
G
S
F
G
E
V
L
K
C
-
K
D
R
I
-
T
Q
----
Q
-
E
Y
A
V
K
V
I
--
N
---
K
A
--
S
--
A
--
K
--
N
---
K
D-
T
--
S
T
---
I
L
--
R
-------
E
V
E
L
L
K
K
L
---
D
H
P
N
I
M
K
L
-
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
-
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
-
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
----
S
K
---
E
KDC------
D
-----
I
--
K
I
I
D
F
G
L
S
T
C
F
Q
--
Q
N
T
--------
I
G
T
A
Y
Y
I
A
P
E
V
L
----
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
-
F
--
Y
G
---
K
--
N
------------
E
-
Y
D
I
L
--
K
--
R
V
-
E
-
T
G
KYAFD
L
P
----
Q
---
W
R
T
I
S
D
D
A
K
D
------
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
----
C
L
E
H
P
W
----
I
Q
----
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
54.43
34%
-27
- C3 -
-
3MWU
1
?
A:
[20-302]
-------
F
A
E
R
Y
N
I
V
---
C
M
L
G
K
G
S
F
G
E
V
L
K
C
-
K
D
R
I
-
T
Q
----
Q
-
E
Y
A
V
K
V
I
--
N
---
K
A
--
S
--
A
--
K
--
N
---
K
D-
T
--
S
T
---
I
L
--
R
-------
E
V
E
L
L
K
K
L
---
D
H
P
N
I
M
K
L
-
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
-
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
-
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
----
S
K
---
E
KDC------
D
-----
I
--
K
I
I
D
F
G
L
S
T
C
F
Q
--
Q
N
-------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
----
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
-
F
--
Y
G
---
K
--
N
------------
E
-
Y
D
I
L
--
K
--
R
V
-
E
-
T
G
KYAFD
L
P
----
Q
---
W
R
T
I
S
D
D
A
K
D
------
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
----
C
L
E
H
P
W
----
I
Q
----
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
54.33
34%
-35
- C3 -
-
2WNT
2
B:
[26-288]
--------
S
D
G
Y
V
V
K
---
E
T
I
G
V
G
S
Y
S
E
C
K
R
C
-
V
H
K
A
-
T
N
----
M
-
E
Y
A
V
K
V
I
--
D
----
K
--
S
--
K
--
R
--
D
---
P
--
S
--
E
E
---
I
-----------
E
I
L
L
-
R
Y
G
---
Q
H
P
N
I
I
T
L
-
K
D
V
Y
D
D
G
K
H
V
Y
L
V
T
E
L
M
R
G
G
E
L
L
D
K
I
-
L
R
Q
K
F
F
S
E
R
E
A
S
F
V
L
H
T
-
I
G
K
T
V
E
Y
L
H
S
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y--
V
---
D
----
E
S
---
G
---------
N
PEC--
L
--
R
I
C
D
F
G
F
A
K
Q
L
R
--
A
E
N
--
G
L
L
M
T
P
C
Y
----------
K
R
--
Q
G
Y
D
-
E
G
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
A
G
Y
T
P
-
F
A-
N
G
---
P
--
S
D
--------
T
P
E
E
I
L
T
R
I
--
G
--
S
G
-
K
-
F
T
-----
L
S
----
G
GN-
W
N
T
V
S
E
T
A
K
D
------
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
-----
T
A
K
Q
----
V
L
Q
H
P
W
----
V
T
----
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
54.31
35%
-16
- C3 -
-
4BFM
1
MELK_MOUSE
A:
[11-278]
-----------
Y
E
L
Y
---
E
T
I
G
T
G
G
F
A
K
V
K
L
A
-
C
H
V
L
-
T
G
----
E
-
M
V
A
I
K
I
M
--
D
----
K
--
N
--
A
--
L
GS
D
---
L
--
P
---
R
---
V
K
--
T
-------
E
I
D
A
L
K
S
L
---
R
H
Q
H
I
C
Q
L
-
Y
H
V
L
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
-
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
-
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
----
E
N
---
H
---------
K
-----
L
--
K
L
I
D
F
G
L
C
A
K
---------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
-------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
-
F
--
D
D
------
D
N
--------
V
M
A
L
-
Y
K
K
I
--
M
--
R
G
-
K
-
Y
E
-----
V
P
----
K
---
W
--
L
S
P
S
S
I
L
------
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
R
N
----
L
L
N
H
P
W
VMQD
Y
S
----
C
P
V
E
W
Q
S
K
T
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
398
Blastp_CBE
54.15
31%
6
- C3 -
-
6BDL
1
KGP1_HUMAN
B:
[33-329]
--------
L
S
D
F
N
I
I
---
D
T
L
G
V
G
G
F
G
R
V
E
L
V
-
Q
L
K
S
-
E
E
S---
K
-
T
F
A
M
K
I
L
--
K
---
K
R
--
H
--
I
--
V
--
D
---
T
RQ
Q
--
E
H
---
I
R
--
S
-------
E
K
Q
I
M
Q
G
A
---
H
S
D
F
I
V
R
L
-
Y
R
T
F
K
D
S
K
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
-
T
I
-
L
R
D
R
G
S
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
K
G
I
I
Y
R
D
L
K
P
E
N
L
I
---
L
---
D
----
H
R
---
G
---------
Y
-----
A
--
K
L
V
D
F
G
F
A
K
K
I
G
--
F
G
K
K
T
W
F
----
C
G
T
P
E
Y
V
A
P
E
I
I
L
N
--
K
G
-
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
S
P
P
-
F
--
S
G
---
P
---
D
--------
P
M
K
T
-
Y
N
I
I
--
L
--
R
G
-
I
-
D
M
-----
I
E
----
F
---
P
K
K
I
A
K
N
A
A
N
------
L
I
K
K
L
C
R
D
N
P
S
E
R
L
GNLKN
G
V
K
D
----
I
Q
K
H
K
W
----
F
E
GFNW
E
G
L
R
K
G
T
L
T
P
P
I
I
-------
P
S
V
A
S
P
T
D
T
S
N
F
D
S
F
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
54.12
38%
-39
- C3 -
-
5KZ7
1
MARK2_HUMAN
A:
[30-287]
---
P
---
H
I
G
N
Y
R
L
L
---
K
T
I
G
K
G
N
F
A
K
V
K
L
A
-
R
H
I
L
-
T
G
----
K
-
E
V
A
V
K
I
I
--
D
---
K
T
--
Q
--
L
--
N
--
S
---
S
--
S
L-
Q
K
---
L
F
--
R
-------
E
V
R
I
M
K
V
L
---
N
H
P
N
I
V
K
L
-
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
-
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
-
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
----
A
D
---
M
---------
N
-----
I
--
K
I
A
D
F
---------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
--
K
--
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
-
F
--
D
-----------------
N
L
K
E
-
L
R
E
R
--
V
--
L
R
-
G
-
K
Y
-----
R
I
----
P
---
F
-
Y
M
S
T
D
C
E
N
------
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
----
I
M
K
D
R
W
----
M
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
209
Blastp_CBE
53.93
35%
-5
- C3 -
-
4REW
1
AAPK1_HUMAN
A:
[8-395]
-----------
Y
I
L
G
---
D
T
L
G
V
G
T
F
G
K
V
K
V
G
-
K
H
E
L
-
T
G
----
H
-
K
V
A
V
K
I
L
--
N
---
R
Q
KI
R
--
S
--
L
--
D
---
V
--
V
--
G
K
---
I
R
--
R
-------
E
I
Q
N
L
K
L
F
---
R
H
P
H
I
I
K
L
-
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
-
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
-
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
----
A
H
---
M
---------
N
-----
A
--
K
I
A
D
F
G
L
S
N
M
M
-----
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
--
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
-
F
--
D
D
DHV
P
--
T
L
--------
F
K
K
I
-
C
D
G
I
--
F
--
Y
T
-
P
-
Q
Y
-----
L
N
----
P
---------
S
V
I
S
------
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
S
I
K
D
----
I
R
E
H
E
W
----
F
K
----
Q
D
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
53.79
36%
-18
- C3 -
-
5ES1
1
MARK4_HUMAN
A:
[12-269]
---
P
---
H
V
G
N
Y
R
L
L
---
R
T
I
G
K
G
N
F
A
K
V
K
L
A
-
R
H
I
L
-
T
G
----
R
-
E
V
A
I
K
I
I
--
D
---
K
T
--
Q
--
L
---------
N
--
P
--
S
S
---
L
Q
--
K
LFR----
E
V
R
I
M
K
G
L
---
N
H
P
N
I
V
K
L
-
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
A
G
E
V
F
D
Y
L
-
V
S
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
-
I
V
S
A
V
H
Y
C
H
Q
K
N
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
----
A
E
---
A
---------
N
-----
I
--
K
I
A
D
F
G
F
S
N
------------------
S
P
P
Y
A
A
P
E
L
F
Q
G
--
K
K
Y
D
G
P
E
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
-
F
--
D
-------
G
H
--------
N
L
K
E
-
L
R
E
R
--
V
--
L
R
-
G
-
K
Y
-----
R
V
----
P
---
F
-
Y
M
S
T
D
C
E
S
------
I
L
R
R
F
L
V
L
N
P
A
K
R
C
-----
T
L
E
Q
----
I
M
K
D
K
W
----
I
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
350
Blastp_CBE
53.78
32%
15
- C3 -
-
5HU3
1
KCC2A_DROME
A:
[9-274]
----CTR
F
S
D
N
Y
D
I
K
---
E
E
L
G
K
G
A
F
S
I
V
K
R
C
-
V
Q
K
S
-
T
G
----
F
-
E
F
A
A
K
I
I
--
N
---
T
K
--
K
LT
A
--
R
--
D
---
F
-----
Q
K
---
L
E
--
R
-------
E
A
R
I
C
R
K
L
---
H
H
P
N
I
V
R
L
-
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
-
V
A
R
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
-
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
N
L
K
P
E
N
L
L
---
L
---
A
----
S
K
---
A
---------
K
GAA--
V
--
K
L
A
D
F
G
L
A
I
E
V
Q
--
G
D
H
Q
A
W
F
--
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
---
K
E
P
Y
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
-------
D
--------
Q
H
R
L
-
Y
S
Q
I
--
K
--
A
G
-
A
Y
D
Y
-----
P
S
----
P
E--
W
D
T
V
T
P
E
A
K
N
------
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
A
A
E
----
A
L
K
H
P
W
----
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
53.69
33%
-7
- C3 -
-
4YZB
1
?
A:
[26-292]
--
A
A
---
F
S
D
R
Y
K
G
Q
---
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
V
-
T
G
----
Q
-
E
Y
A
V
K
V
I
--
S
----
K
--
R
------------
Q
--
K
--
T
D
---
K
E
--
L
-------
L
L
K
E
V
E
L
L
KKL
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
N
K
RKD
A
---------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
S
T
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
--
N
G
---
A
--
N
E
--------
F
D
I
L
-
K
K
V
E
--
K
--
G
K
-
F
-
T
F
D----
L
P
----
Q
---
W
K
K
V
S
E
P
A
K
D
------
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
-----
S
A
R
D
----
A
L
E
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
399
Blastp_CBE
53.65
31%
7
- C3 -
-
6BDL
1
KGP1_HUMAN
A:
[33-329]
--------
L
S
D
F
N
I
I
---
D
T
L
G
V
G
G
F
G
R
V
E
L
V
-
Q
L
K
S
-
E
E
S---
K
-
T
F
A
M
K
I
L
--
K
---
K
R
--
H
--
I
--
V
--
D
---
T
RQ
Q
--
E
H
---
I
R
--
S
-------
E
K
Q
I
M
Q
G
A
---
H
S
D
F
I
V
R
L
-
Y
R
T
F
K
D
S
K
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
-
T
I
-
L
R
D
R
G
S
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
K
G
I
I
Y
R
D
L
K
P
E
N
L
I
---
L
---
D
----
H
R
---
G
---------
Y
-----
A
--
K
L
V
D
F
G
F
A
K
K
I
G
--
F
G
K
K
T
W
F
----
C
G
T
P
E
Y
V
A
P
E
I
I
L
N
--
K
G
-
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
S
P
P
-
F
--
S
G
---
P
---
D
--------
P
M
K
T
-
Y
N
I
I
--
L
--
R
G
-
I
-
D
M
-----
I
E
----
F
---
P
K
K
I
A
K
N
A
A
N
------
L
I
K
K
L
C
R
D
N
P
S
E
R
L
GNLKN
G
V
K
D
----
I
Q
K
H
K
W
----
F
E
GFNW
E
G
L
R
K
G
T
L
T
P
P
I
I
-------
P
S
V
A
S
P
T
D
T
S
N
F
D
S
F
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
579
HHSearch
53.58
34%
5
- C3 -
-
6C9H
2
AAPK1_HUMAN
A:
[11-323]
---
V
---
K
I
G
H
Y
I
L
G
---
D
T
L
G
V
G
T
F
G
K
V
K
V
G
-
K
H
E
L
-
T
G
----
H
-
K
V
A
V
K
I
L
--
N
---
R
Q
--
K
--
I
RS
L
--
D
---
V
--
V
--
G
K
---
I
R
--
R
-------
E
I
Q
N
L
K
L
F
---
R
H
P
H
I
I
K
L
-
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
-
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
-
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
----
A
H
---
M
---------
N
-----
A
--
K
I
A
D
F
G
L
S
N
M
M
S
--
D
G
---
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
--
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
-
F
--
D
D
---
D
--
H
V
--------
P
-
T
L
-
F
K
K
I
--
C
--
D
G
-
I
-
F
Y
-----
T
---------
P
Q
Y
L
N
P
S
V
I
S
------
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
----
I
R
E
H
E
W
----
F
K
----
Q
D
L
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
53.42
35%
-4
- C3 -
-
6C9H
2
AAPK1_HUMAN
A:
[16-324]
-----------
Y
I
L
G
---
D
T
L
G
V
G
T
F
G
K
V
K
V
G
-
K
H
E
L
-
T
G
----
H
-
K
V
A
V
K
I
L
--
N
---
R
Q
KI
R
--
S
--
L
--
D
---
V
--
V
--
G
K
---
I
R
--
R
-------
E
I
Q
N
L
K
L
F
---
R
H
P
H
I
I
K
L
-
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
-
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
-
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
----
A
H
---
M
---------
N
-----
A
--
K
I
A
D
F
G
L
S
N
M
M
-----
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
--
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
-
F
--
D
D
DHV
P
--
T
L
--------
F
K
K
I
-
C
D
G
I
--
F
--
Y
T
-
P
-
Q
Y
-----
L
N
----
P
---------
S
V
I
S
------
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
----
I
R
E
H
E
W
----
F
K
----
Q
D
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
53.38
36%
2
- C3 -
-
4WG5
1
?
A:
[32-284]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
53.31
31%
12
- C3 -
-
6C0T
3
KGP1_HUMAN
A:
[33-329]
--------
L
S
D
F
N
I
I
---
D
T
L
G
V
G
G
F
G
R
V
E
L
V
-
Q
L
K
S
-
E
E
S---
K
-
T
F
A
M
K
I
L
--
K
---
K
R
--
H
--
I
--
V
--
D
---
T
RQ
Q
--
E
H
---
I
R
--
S
-------
E
K
Q
I
M
Q
G
A
---
H
S
D
F
I
V
R
L
-
Y
R
T
F
K
D
S
K
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
-
T
I
-
L
R
D
R
G
S
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
K
G
I
I
Y
R
D
L
K
P
E
N
L
I
---
L
---
D
----
H
R
---
G
---------
Y
-----
A
--
K
L
V
D
F
G
F
A
K
K
I
G
--
F
G
K
K
T
W
F
----
C
G
T
P
E
Y
V
A
P
E
I
I
L
N
--
K
G
-
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
S
P
P
-
F
--
S
G
---
P
---
D
--------
P
M
K
T
-
Y
N
I
I
--
L
--
R
G
-
I
-
D
M
-----
I
E
----
F
---
P
K
K
I
A
K
N
A
A
N
------
L
I
K
K
L
C
R
D
N
P
S
E
R
L
GNLKN
G
V
K
D
----
I
Q
K
H
K
W
----
F
E
GFNW
E
G
L
R
K
G
T
L
T
P
P
I
I
-------
P
S
V
A
S
P
T
D
T
S
N
F
D
S
F
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
274
Blastp_CBE
53.24
36%
-0
- C3 -
-
3SXF
3
?
A:
[32-295]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
53.12
38%
-33
- C3 -
-
5KZ7
1
MARK2_HUMAN
B:
[30-287]
---
P
---
H
I
G
N
Y
R
L
L
---
K
T
I
G
K
G
N
F
A
K
V
K
L
A
-
R
H
I
L
-
T
G
----
K
-
E
V
A
V
K
I
I
--
D
---
K
T
--
Q
--
L
--
N
--
S
---
S
--
S
L-
Q
K
---
L
F
--
R
-------
E
V
R
I
M
K
V
L
---
N
H
P
N
I
V
K
L
-
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
-
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
-
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
----
A
D
---
M
---------
N
-----
I
--
K
I
A
D
F
---------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
--
K
--
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
-
F
--
D
-----------------
N
L
K
E
-
L
R
E
R
--
V
--
L
R
-
G
-
K
Y
-----
R
I
----
P
---
F
-
Y
M
S
T
D
C
E
N
------
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
----
I
M
K
D
R
W
----
M
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
53.10
36%
-5
- C3 -
-
5W9E
1
?
A:
[32-297]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
53.07
35%
-6
- C3 -
-
6E4W
2
?
A:
[15-407]
--------
I
G
H
Y
I
L
G
---
D
T
L
G
V
G
T
F
G
K
V
K
V
G
-
K
H
E
L
-
T
G
----
H
-
K
V
A
V
K
I
L
--
N
---
R
Q
KI
R
--
S
--
L
--
D
---
V
--
V
--
G
K
---
I
R
--
R
-------
E
I
Q
N
L
K
L
F
---
R
H
P
H
I
I
K
L
-
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
-
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
-
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
----
A
H
---
M
---------
N
-----
A
--
K
I
A
D
F
G
L
S
N
M
M
----
S
D
G
E
F
L
--
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
--
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
-
F
--
D
D
DHV
P
--
T
L
--------
F
K
K
I
-
C
D
G
I
--
F
--
Y
T
-
P
-
Q
Y
-----
L
N
----
P
---------
S
V
I
S
------
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
----
I
R
E
H
E
W
----
F
K
----
Q
D
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
52.91
36%
1
- C3 -
-
4YJN
1
?
A:
[32-289]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
52.85
34%
-17
- C3 -
-
6BX6
1
AAPK2_HUMAN
A:
[10-269]
--------
I
G
H
Y
V
L
G
---
D
T
L
G
V
G
T
F
G
K
V
K
I
G
-
E
H
Q
L
-
T
G
----
H
-
K
V
A
V
K
I
L
--
N
---
R
Q
KI
R
--
S
--
L
--
D
---
V
--
V
--
G
K
---
I
K
--
R
-------
E
I
Q
N
L
K
L
F
---
R
H
P
H
I
I
K
L
-
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
-
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
-
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
----
A
H
---
M
---------
N
-----
A
--
K
I
A
D
F
G
L
S
---------------------
N
Y
A
A
P
E
--------
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
-
F
--
D
D
---
E
--
H
V
--------
P
T
L
--
F
K
K
I
--
R
--
G
G
-
V
-
F
Y
-----
I
P
----
E
---
Y
--
L
N
R
S
V
A
T
------
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
----
I
R
E
H
E
W
----
F
K
----
Q
D
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
52.80
36%
-2
- C3 -
-
5W9R
1
?
A:
[32-303]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
52.58
36%
-0
- C3 -
-
5W8R
1
?
A:
[32-292]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
52.56
36%
-3
- C3 -
-
4ONA
1
?
A:
[32-284]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
52.57
36%
-1
- C3 -
-
4MX9
1
?
A:
[33-291]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
52.56
36%
1
- C3 -
-
4MXA
1
?
A:
[33-291]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
52.53
35%
3
- C3 -
-
3MA6
1
?
A:
[30-290]
-------
F
S
D
R
Y
K
G
Q
---
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
---
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
52.44
36%
-2
- C3 -
-
3T3U
5
?
A:
[32-295]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
52.29
34%
-10
- C3 -
-
3AQV
1
AAPK2_HUMAN
A:
[10-269]
--------
I
G
H
Y
V
L
G
---
D
T
L
G
V
G
T
F
G
K
V
K
I
G
-
E
H
Q
L
-
T
G
----
H
-
K
V
A
V
K
I
L
--
N
---
R
Q
KI
R
--
S
--
L
--
D
---
V
--
V
--
G
K
---
I
K
--
R
-------
E
I
Q
N
L
K
L
F
---
R
H
P
H
I
I
K
L
-
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
-
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
-
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
----
A
H
---
M
---------
N
-----
A
--
K
I
A
D
F
G
L
S
N
M
M
-----
S
D
G
E
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
--
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
-
F
--
D
D
---
E
--
H
V
--------
P
T
L
--
F
K
K
I
--
R
--
G
G
-
V
-
F
Y
-----
I
P
----
E
---
Y
--
L
N
R
S
V
A
T
------
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
----
I
R
E
H
E
W
----
F
K
----
Q
D
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
277
Blastp_CBE
52.16
36%
-3
- C3 -
-
3I7B
4
?
A:
[32-287]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
269
Blastp_CBE
52.05
36%
1
- C3 -
-
3V51
1
?
A:
[32-290]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
276
Blastp_CBE
52.02
36%
2
- C3 -
-
3N51
3
?
A:
[32-299]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
52.03
36%
1
- C3 -
-
4M84
1
?
A:
[32-284]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
52.02
36%
2
- C3 -
-
5W91
1
?
A:
[32-298]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
52.00
36%
4
- C3 -
-
3UPX
1
?
A:
[32-303]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
52.00
36%
1
- C3 -
-
4WG3
1
?
A:
[32-289]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
51.91
35%
-2
- C3 -
-
6E4T
2
?
A:
[15-407]
--------
I
G
H
Y
I
L
G
---
D
T
L
G
V
G
T
F
G
K
V
K
V
G
-
K
H
E
L
-
T
G
----
H
-
K
V
A
V
K
I
L
--
N
---
R
Q
KI
R
--
S
--
L
--
D
---
V
--
V
--
G
K
---
I
R
--
R
-------
E
I
Q
N
L
K
L
F
---
R
H
P
H
I
I
K
L
-
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
-
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
-
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
----
A
H
---
M
---------
N
-----
A
--
K
I
A
D
F
G
L
S
N
M
M
----
S
D
G
E
F
L
--
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
--
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
-
F
--
D
D
DHV
P
--
T
L
--------
F
K
K
I
-
C
D
G
I
--
F
--
Y
T
-
P
-
Q
Y
-----
L
N
----
P
---------
S
V
I
S
------
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
----
I
R
E
H
E
W
----
F
K
----
Q
D
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
51.83
36%
3
- C3 -
-
4TZR
1
?
A:
[32-289]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
51.83
35%
-5
- C3 -
-
6B2E
2
AAPK2_HUMAN
A:
[26-385]
--------
I
G
H
Y
V
L
G
---
D
T
L
G
V
G
T
F
G
K
V
K
I
G
-
E
H
Q
L
-
T
G
----
H
-
K
V
A
V
K
I
L
--
N
---
R
Q
KI
R
--
S
--
L
--
D
---
V
--
V
--
G
K
---
I
K
--
R
-------
E
I
Q
N
L
K
L
F
---
R
H
P
H
I
I
K
L
-
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
-
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
-
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
----
A
H
---
M
---------
N
-----
A
--
K
I
A
D
F
G
L
S
N
M
M
----
S
D
G
E
F
L
--
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
--
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
-
F
--
D
D
------
E
H
--------
V
P
T
L
-
F
K
K
I
--
R
--
G
G
-
V
-
F
Y
-----
I
P
----
E
---
Y
--
L
N
R
S
V
A
T
------
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
----
I
R
E
H
E
W
----
F
K
----
Q
G
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
51.74
36%
3
- C3 -
-
4JBV
1
?
A:
[32-289]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
51.72
33%
-3
- C3 -
-
4YUQ
1
?
B:
[26-291]
--
A
A
---
F
S
D
R
Y
K
G
Q
---
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
V
-
T
G
----
Q
-
E
Y
A
V
K
V
I
--
S
----
K
--
R
--
Q
--------------------------------
L
L
K
E
V
E
L
L
KKL
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
N
K
RKD
A
---------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
S
T
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
--
N
G
---
A
--
N
E
--------
F
D
I
L
-
K
K
V
E
--
K
--
G
K
-
F
-
T
F
D----
L
P
----
Q
---
W
K
K
V
S
E
P
A
K
D
------
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
-----
S
A
R
D
----
A
L
E
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
51.71
36%
-0
- C3 -
-
5W80
1
?
A:
[32-295]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
51.52
31%
-32
- C3 -
-
2X4F
4
MYLK4_HUMAN
A:
[94-345]
--------------
T
---
E
I
L
G
-----
Q
V
H
K
C
-
E
E
T
A
-
T
G
----
L
-
K
L
A
A
K
I
I
--
K
---
T
---
R
--
G
--
M
--
K
---
D
--
K
--
E
E
---
V
K
--
N
-------
E
I
S
V
M
N
Q
L
---
D
H
A
N
L
I
Q
L
-
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
-
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
---
C
---
V
----
N
R
---
D
AK-------
Q
-----
I
--
K
I
I
D
F
G
L
A
R
--
R
--
Y
K
P
R
E
K
L
K
V
N
F
-
G
T
P
E
F
L
A
P
E
V
V
-
N
--
Y
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
-
F
--
L
G
---
D
--
N
D
AETLNNIL
A
C
R
-----
W
--
D
--
L
E
-
D
---------
E
----
E
---
F
Q
D
I
S
E
E
A
K
E
------
F
I
S
K
L
L
I
K
E
K
S
W
R
I
-----
S
A
S
E
----
A
L
K
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
51.50
36%
-17
- C3 -
-
3HZT
9
?
A:
[9-297]
--------------
V
---
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
-
K
D
K
L
-
T
G
----
A
-
E
R
A
I
K
I
I
--
K
----
K
--
S
--
S
--
V
--
T
---
T
--
T
--
S
N
SGA
L
L
--
D
-------
E
V
A
V
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
-
I
L
R
Q
K
F
S
E
V
D
A
A
V
I
M
K
Q
-
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
SK--
S
R
---
D
---------
A
-----
L
I-
K
I
V
D
F
G
L
S
A
H
F
E
--
V
-----------
G
T
A
Y
Y
I
A
P
E
V
L
R
K
--
K
--
Y
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
-
F
--
G
G
---
Q
--
T
D
----------
Q
E
-
I
L
K
R
--
V
--
E
K
-
G
-
K
F
S----
F
D
----
P
PD-
W
T
Q
V
S
D
E
A
K
Q
------
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
-----
S
A
E
E
----
A
L
N
H
P
W
----
I
V
----
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
51.50
36%
-2
- C3 -
-
3V5T
1
?
A:
[32-289]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
51.48
36%
3
- C3 -
-
6BFA
1
?
A:
[32-284]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
51.44
33%
-2
- C3 -
-
4YUQ
1
?
A:
[26-291]
--
A
A
---
F
S
D
R
Y
K
G
Q
---
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
V
-
T
G
----
Q
-
E
Y
A
V
K
V
I
--
S
----
K
--
R
--
Q
------------------------
L
-------
L
L
K
E
V
E
L
L
KKL
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
N
K
RKD
A
---------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
S
T
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
--
N
G
---
A
--
N
E
--------
F
D
I
L
-
K
K
V
E
--
K
--
G
K
-
F
-
T
F
D----
L
P
----
Q
---
W
K
K
V
S
E
P
A
K
D
------
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
-----
S
A
R
D
----
A
L
E
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
51.43
35%
-3
- C3 -
-
5T5T
2
AAPK1_RAT
A:
[15-400]
--------
I
G
H
Y
I
L
G
---
D
T
L
G
V
G
T
F
G
K
V
K
V
G
-
K
H
E
L
-
T
G
----
H
-
K
V
A
V
K
I
L
--
N
---
R
Q
KI
R
--
S
--
L
--
D
---
V
--
V
--
G
K
---
I
R
--
R
-------
E
I
Q
N
L
K
L
F
---
R
H
P
H
I
I
K
L
-
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
-
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
-
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
----
A
H
---
M
---------
N
-----
A
--
K
I
A
D
F
G
L
S
N
M
M
----
S
D
G
E
F
L
--
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
--
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
-
F
--
D
D
DHV
P
--
T
L
--------
F
K
K
I
-
C
D
G
I
--
F
--
Y
T
-
P
-
Q
Y
-----
L
N
----
P
---------
S
V
I
S
------
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
----
I
R
E
H
E
W
----
F
K
----
Q
D
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
51.43
35%
-2
- C3 -
-
5UFU
2
AAPK1_MOUSE (first)
A:
[15-400]
--------
I
G
H
Y
I
L
G
---
D
T
L
G
V
G
T
F
G
K
V
K
V
G
-
K
H
E
L
-
T
G
----
H
-
K
V
A
V
K
I
L
--
N
---
R
Q
KI
R
--
S
--
L
--
D
---
V
--
V
--
G
K
---
I
R
--
R
-------
E
I
Q
N
L
K
L
F
---
R
H
P
H
I
I
K
L
-
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
-
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
-
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
----
A
H
---
M
---------
N
-----
A
--
K
I
A
D
F
G
L
S
N
M
M
----
S
D
G
E
F
L
--
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
--
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
-
F
--
D
D
DHV
P
--
T
L
--------
F
K
K
I
-
C
D
G
I
--
F
--
Y
T
-
P
-
Q
Y
-----
L
N
----
P
---------
S
V
I
S
------
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
----
I
R
E
H
E
W
----
F
K
----
Q
D
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
270
Blastp_CBE
51.41
36%
2
- C3 -
-
3UPZ
1
?
A:
[32-290]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
218
Blastp_CBE
51.41
35%
-2
- C3 -
-
4QFG
1
A:
[15-403]
--------
I
G
H
Y
I
L
G
---
D
T
L
G
V
G
T
F
G
K
V
K
V
G
-
K
H
E
L
-
T
G
----
H
-
K
V
A
V
K
I
L
--
N
---
R
Q
KI
R
--
S
--
L
--
D
---
V
--
V
--
G
K
---
I
R
--
R
-------
E
I
Q
N
L
K
L
F
---
R
H
P
H
I
I
K
L
-
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
-
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
-
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
----
A
H
---
M
---------
N
-----
A
--
K
I
A
D
F
G
L
S
N
M
M
----
S
D
G
E
F
L
--
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
--
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
-
F
--
D
D
DHV
P
--
T
L
--------
F
K
K
I
-
C
D
G
I
--
F
--
Y
T
-
P
-
Q
Y
-----
L
N
----
P
---------
S
V
I
S
------
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
----
I
R
E
H
E
W
----
F
K
----
Q
D
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
268
Blastp_CBE
51.39
36%
5
- C3 -
-
3V5P
1
?
A:
[32-299]
------------------
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
470
Blastp_CBE
51.27
31%
-30
- C3 -
-
2X4F
3
MYLK4_HUMAN
B:
[94-345]
--------------
T
---
E
I
L
G
G
G
--
G
Q
V
H
K
C
-
E
E
T
A
-
T
G
----
L
-
K
L
A
A
K
I
I
--
K
---
T
---
R
--
G
--
M
--
K
---
D
--
K
--
E
E
---
V
K
--
N
-------
E
I
S
V
M
N
Q
L
---
D
H
A
N
L
I
Q
L
-
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
-
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
---
C
---
V
----
N
R
---
D
AK-------
Q
-----
I
--
K
I
I
D
F
G
L
A
R
--
R
--
Y
K
P
R
E
K
L
K
V
N
F
-
G
T
P
E
F
L
A
P
E
V
V
-
N
--
Y
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
-
F
--
L
G
---
D
--
N
D
AETLNNIL
A
C
R
-----
W
--
D
--
L
E
-
D
---------
E
----
E
---
F
Q
D
I
S
E
E
A
K
E
------
F
I
S
K
L
L
I
K
E
K
S
W
R
I
-----
S
A
S
E
----
A
L
K
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
51.02
35%
-1
- C3 -
-
6E4U
2
AAPK1_RAT
A:
[15-403]
--------
I
G
H
Y
I
L
G
---
D
T
L
G
V
G
T
F
G
K
V
K
V
G
-
K
H
E
L
-
T
G
----
H
-
K
V
A
V
K
I
L
--
N
---
R
Q
KI
R
--
S
--
L
--
D
---
V
--
V
--
G
K
---
I
R
--
R
-------
E
I
Q
N
L
K
L
F
---
R
H
P
H
I
I
K
L
-
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
-
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
-
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
----
A
H
---
M
---------
N
-----
A
--
K
I
A
D
F
G
L
S
N
M
M
----
S
D
G
E
F
L
--
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
--
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
-
F
--
D
D
DHV
P
--
T
L
--------
F
K
K
I
-
C
D
G
I
--
F
--
Y
T
-
P
-
Q
Y
-----
L
N
----
P
---------
S
V
I
S
------
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
----
I
R
E
H
E
W
----
F
K
----
Q
D
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
467
Blastp_CBE
50.94
31%
-10
- C3 -
-
4AF3
1
AURKB_HUMAN
A:
[22-274]
--------
I
D
D
F
E
I
G
---
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
K
-
S
H
----
F
-
I
V
A
L
K
V
L
------
F
K
--
S
--
Q
--
I
--
E
KEG
V
--
E
--
H
Q
---
L
R
--
R
-------
E
I
E
I
Q
A
H
L
---
H
H
P
N
I
L
R
L
-
Y
N
Y
F
Y
D
R
R
R
I
Y
L
I
L
E
Y
A
P
R
G
E
L
Y
K
E
L
-
Q
K
S
C
T
F
D
E
Q
R
T
A
T
I
M
E
E
-
L
A
D
A
L
M
Y
C
H
G
K
K
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
----
L
K
---
G
---------
E
-----
L
--
K
I
A
D
F
G
----------------------
L
D
Y
L
P
P
E
M
I
E
G
--
R
-
M
H
N
E
K
V
D
L
W
C
I
G
V
L
C
Y
E
L
L
V
G
N
P
P
-
F
--
E
S
---
A
--
S
H
--------
N
-
E
T
-
Y
R
----
R
--
I
V
-
K
-
V
D
-----
L
K
----
F
---
P
A
S
V
P
T
G
A
Q
D
------
L
I
S
K
L
L
R
H
N
P
S
E
R
L
-----
P
L
A
Q
----
V
S
A
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
50.58
35%
-9
- C3 -
-
3MA6
1
?
B:
[30-290]
-------
F
S
D
R
Y
K
G
Q
---
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
-----
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
50.47
35%
-4
- C3 -
-
3I7C
1
?
A:
[24-287]
-------
F
S
D
R
Y
K
G
Q
---
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
I
-
T
G
----
Q
-
E
C
A
V
K
V
I
--
S
KRQ
V
K
--
Q
--
K
--
T
--
D
------
K
--
E
S
---
L
L
--
R
-------
E
V
Q
L
L
K
Q
L
---
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
S
K
---
S
KDA------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
A
S
K
K
K
----
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
-----------
N
--------
G
A
N
E
-
Y
D
I
L
--
K
KV
E
K
-
G
-
K
Y
TFE--
L
P
----
Q
---
W
K
K
V
S
E
S
A
K
D
------
L
I
R
K
-
L
T
Y
V
P
S
-
R
I
-----
S
A
R
D
----
A
L
D
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
50.13
35%
-3
- C3 -
-
4QFS
2
AAPK1_RAT
A:
[15-407]
--------
I
G
H
Y
I
L
G
---
D
T
L
G
V
G
T
F
G
K
V
K
V
G
-
K
H
E
L
-
T
G
----
H
-
K
V
A
V
K
I
L
--
N
---
R
Q
KI
R
--
S
--
L
--
D
---
V
--
V
--
G
K
---
I
R
--
R
-------
E
I
Q
N
L
K
L
F
---
R
H
P
H
I
I
K
L
-
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
-
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
-
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
----
A
H
---
M
---------
N
-----
A
--
K
I
A
D
F
G
L
S
N
M
M
----
S
D
G
E
F
L
--
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
--
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
-
F
--
D
D
DHV
P
--
T
L
--------
F
K
K
I
-
C
D
G
I
--
F
--
Y
T
-
P
-
Q
Y
-----
L
N
----
P
---------
S
V
I
S
------
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
----
I
R
E
H
E
W
----
F
K
----
Q
D
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
49.94
33%
-2
- C3 -
-
4YSJ
1
?
B:
[26-290]
--
A
A
---
F
S
D
R
Y
K
G
Q
---
R
V
L
G
K
G
S
F
G
E
V
I
L
C
-
K
D
K
V
-
T
G
----
Q
-
E
Y
A
V
K
V
I
--
S
----
K
--
R
-----------------------------------
L
L
K
E
V
E
L
L
KKL
D
H
P
N
I
M
K
L
-
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
-
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
-
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
----
N
K
RKD
A
---------
N
-----
I
--
R
I
I
D
F
G
L
S
T
H
F
E
--
S
T
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
--
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
--
N
G
---
A
--
N
E
--------
F
D
I
L
-
K
K
V
E
--
K
--
G
K
-
F
-
T
F
D----
L
P
----
Q
---
W
K
K
V
S
E
P
A
K
D
------
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
-----
S
A
R
D
----
A
L
E
H
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
49.81
35%
-4
- C3 -
-
4CFH
1
AAPK1_RAT
A:
[35-352]
-----------
Y
I
L
G
---
D
T
L
G
V
G
T
F
G
K
V
K
V
G
-
K
H
E
L
-
T
G
----
H
-
K
V
A
V
K
I
L
--
N
---
R
Q
KI
R
--
S
--
L
--
D
---
V
--
V
--
G
K
---
I
R
--
R
-------
E
I
Q
N
L
K
L
F
---
R
H
P
H
I
I
K
L
-
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
-
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
-
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
----
A
H
---
M
---------
N
-----
A
--
K
I
A
D
F
G
L
S
N
M
M
----
S
D
G
E
F
L
--
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
--
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
-
F
--
D
D
DHV
P
--
T
L
--------
F
K
K
I
-
C
D
G
I
--
F
--
Y
T
-
P
-
Q
Y
-----
L
N
----
P
---------
S
V
I
S
------
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
----
I
R
E
H
E
W
----
F
K
----
Q
D
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
49.77
33%
-52
- C3 -
-
6QAT
1
ULK2_HUMAN
A:
[19-246]
--------------------
V
G
H
G
A
F
A
V
V
F
R
G
-
R
H
R
Q
K
T
D
----
W
-
E
V
A
I
K
S
I
--
N
---
K
K
--
N
--
L
--
S
--
K
---
S
--
Q
--
I
L
---
L
G
--
K
-------
E
I
K
I
L
K
E
L
---
Q
H
E
N
I
V
A
L
-
Y
D
V
Q
E
L
P
N
S
V
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
Q
A
K
G
T
L
S
E
D
T
I
R
V
F
L
H
Q
-
I
A
A
A
M
R
I
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
----
Y
A
---
N
VSGI-----
R
-----
I
--
K
I
A
D
F
G
F
A
---
R
--
Y
L
H
----------
S
P
M
Y
M
A
P
E
V
I
M
S
--
Q
H
Y
D
A
K
-
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
-
F
--
Q
-------
A
N
--------
S
P
Q
D
-
L
R
M
F
--
Y
--
E
K
-
N
-
R
S
-----
L
M
----
P
---
S
I
P
R
E
T
S
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
49.74
36%
35
- C3 -
-
3Q5I
1
?
A:
[36-309]
---------
E
S
Y
F
K
V
---
R
K
L
G
S
--
Y
G
E
V
L
L
C
-
K
E
K
N
-
G
H
----
S
-
E
K
A
I
K
V
I
KK------------------------------------
K
FHEEIYN
E
I
S
L
L
K
S
L
---
D
H
P
N
I
I
K
L
-
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
-
I
N
R
H
K
F
D
E
C
D
A
A
N
I
M
K
Q
-
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
---
L
---
E
----
N
K
---
N
SLL------
N
-----
I
--
K
I
V
D
F
G
L
S
S
F
F
S
KD
Y
K
L
R
D
R
L
-----
G
T
A
Y
Y
I
A
P
E
V
L
K
K
--
K
--
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
-
F
--
G
G
---
Q
--
N
D
----------
Q
D
-
I
I
K
K
--
V
--
E
K
-
G
-
K
Y
YFD--
F
N
----
D
---
W
K
N
I
S
D
E
A
K
E
------
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
-----
T
A
E
E
----
A
L
N
S
R
W
----
I
K
----
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
49.71
35%
-1
- C3 -
-
4QFR
2
?
A:
[15-407]
--------
I
G
H
Y
I
L
G
---
D
T
L
G
V
G
T
F
G
K
V
K
V
G
-
K
H
E
L
-
T
G
----
H
-
K
V
A
V
K
I
L
--
N
---
R
Q
KI
R
--
S
--
L
--
D
---
V
--
V
--
G
K
---
I
R
--
R
-------
E
I
Q
N
L
K
L
F
---
R
H
P
H
I
I
K
L
-
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
-
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
-
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
----
A
H
---
M
---------
N
-----
A
--
K
I
A
D
F
G
L
S
N
M
M
----
S
D
G
E
F
L
--
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
--
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
-
F
--
D
D
DHV
P
--
T
L
--------
F
K
K
I
-
C
D
G
I
--
F
--
Y
T
-
P
-
Q
Y
-----
L
N
----
P
---------
S
V
I
S
------
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
----
I
R
E
H
E
W
----
F
K
----
Q
D
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
49.67
35%
-1
- C3 -
-
5KQ5
2
?
A:
[15-405]
--------
I
G
H
Y
I
L
G
---
D
T
L
G
V
G
T
F
G
K
V
K
V
G
-
K
H
E
L
-
T
G
----
H
-
K
V
A
V
K
I
L
--
N
---
R
Q
KI
R
--
S
--
L
--
D
---
V
--
V
--
G
K
---
I
R
--
R
-------
E
I
Q
N
L
K
L
F
---
R
H
P
H
I
I
K
L
-
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
-
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
-
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
----
A
H
---
M
---------
N
-----
A
--
K
I
A
D
F
G
L
S
N
M
M
----
S
D
G
E
F
L
--
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
--
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
-
F
--
D
D
DHV
P
--
T
L
--------
F
K
K
I
-
C
D
G
I
--
F
--
Y
T
-
P
-
Q
Y
-----
L
N
----
P
---------
S
V
I
S
------
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
----
I
R
E
H
E
W
----
F
K
----
Q
D
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
460
Blastp_CBE
49.55
32%
0
- C3 -
-
6FDY
2
ULK3_HUMAN
U:
[8-270]
---
P
---
R
L
D
G
F
I
L
T
---
E
R
L
G
-----
T
V
Y
K
A
Y
A
K
K
D
-
T
R
----
E
-
V
V
A
I
K
C
V
--
A
---
K
K
--
S
--
L
--
N
--
K
---
A
--
S
V-
E
N
---
L
L
--
T
-------
E
I
E
I
L
K
G
I
---
R
H
P
H
I
V
Q
L
-
K
D
F
Q
W
D
S
D
N
I
Y
L
I
M
E
F
C
A
G
G
D
L
S
R
F
I
-
H
T
R
R
I
L
P
E
K
V
A
R
V
F
M
Q
Q
-
L
A
S
A
L
Q
F
L
H
E
R
N
I
S
H
L
D
L
K
P
Q
N
I
L
---
L
---
S
SL--
E
K
---
P
---------
H
-----
L
--
K
L
A
D
F
G
F
A
Q
H
M
S
--
P
W
D
E
K
H
V
L
R
---
G
S
P
L
Y
M
A
P
E
M
V
C
Q
--
R
Q
Y
D
A
R
-
V
D
L
W
S
M
G
V
I
L
Y
E
A
L
F
G
--------
Q
---
P
--
P
F
--------
A
S
R
S
-
F
S
E
L
-----
E
E
-
K
-
I
R
-----
S
N
----
R
---
V
I
E
L
P
L
R
P
L
L
SRDCRD
L
L
Q
R
L
L
E
R
D
P
S
R
R
I
-----
S
F
Q
D
----
F
F
A
H
P
W
----
V
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
49.27
33%
-40
- C3 -
-
6QAU
6
ULK2_HUMAN
A:
[19-246]
--------------------
V
G
H
G
A
F
A
V
V
F
R
G
-
R
H
R
Q
K
T
D
----
W
-
E
V
A
I
K
S
I
--
N
---
K
K
--
N
--
L
--
S
--
K
---
S
--
Q
--
I
L
---
L
G
--
K
-------
E
I
K
I
L
K
E
L
---
Q
H
E
N
I
V
A
L
-
Y
D
V
Q
E
L
P
N
S
V
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
Q
A
K
G
T
L
S
E
D
T
I
R
V
F
L
H
Q
-
I
A
A
A
M
R
I
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
----
Y
A
---
N
RRKSSVSGI
R
-----
I
--
K
I
A
D
F
G
F
A
---
R
--
Y
L
H
S
N
M
M
A
A
D
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
S
--
Q
H
Y
D
A
K
-
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
-
F
--
Q
-------
A
N
--------
S
P
Q
D
-
L
R
M
F
--
Y
--
E
K
-
N
-
R
S
-----
L
M
----
P
---
S
I
P
R
E
T
S
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
49.15
35%
-1
- C3 -
-
4RER
2
AAPK1_HUMAN
A:
[8-347]
-----------
Y
I
L
G
---
D
T
L
G
V
G
T
F
G
K
V
K
V
G
-
K
H
E
L
-
T
G
----
H
-
K
V
A
V
K
I
L
--
N
---
R
Q
KI
R
--
S
--
L
--
D
---
V
--
V
--
G
K
---
I
R
--
R
-------
E
I
Q
N
L
K
L
F
---
R
H
P
H
I
I
K
L
-
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
-
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
-
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
----
A
H
---
M
---------
N
-----
A
--
K
I
A
D
F
G
L
S
N
M
M
----
S
D
G
E
F
L
--
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
--
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
-
F
--
D
D
DHV
P
--
T
L
--------
F
K
K
I
-
C
D
G
I
--
F
--
Y
T
-
P
-
Q
Y
-----
L
N
----
P
---------
S
V
I
S
------
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
S
I
K
D
----
I
R
E
H
E
W
----
F
K
----
Q
D
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
48.30
33%
-53
- C3 -
-
6QAT
1
ULK2_HUMAN
D:
[19-246]
--------------------
V
G
H
G
A
F
A
V
V
F
R
G
-
R
H
R
Q
K
T
D
----
W
-
E
V
A
I
K
S
I
--
N
---
K
K
--
N
--
L
--
S
--
K
---
S
--
Q
--
I
L
---
L
G
--
K
-------
E
I
K
I
L
K
E
L
---
Q
H
E
N
I
V
A
L
-
Y
D
V
Q
E
L
P
N
S
V
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
Q
A
K
G
T
L
S
E
D
T
I
R
V
F
L
H
Q
-
I
A
A
A
M
R
I
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
----
Y
A
----VSGI-----
R
-----
I
--
K
I
A
D
F
G
F
A
---
R
--
Y
L
------------
P
M
Y
M
A
P
E
V
I
M
S
--
Q
H
Y
D
A
K
-
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
-
F
--
Q
-------
A
N
--------
S
P
Q
D
-
L
R
M
F
--
Y
--
E
K
-
N
-
R
S
-----
L
M
----
P
---
S
I
P
R
E
T
S
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
47.97
33%
-45
- C3 -
-
6QAT
1
ULK2_HUMAN
B:
[19-273]
--------------------
V
G
H
G
A
F
A
V
V
F
R
G
-
R
H
R
Q
K
T
D
----
W
-
E
V
A
I
K
S
I
--
N
---
K
K
--
N
--
L
--
S
--
K
---
S
--
Q
--
I
L
---
L
G
--
K
-------
E
I
K
I
L
K
E
L
---
Q
H
E
N
I
V
A
L
-
Y
D
V
Q
E
L
P
N
S
V
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
Q
A
K
G
T
L
S
E
D
T
I
R
V
F
L
H
Q
-
I
A
A
A
M
R
I
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
----
Y
A
---
N
VSGI-----
R
-----
I
--
K
I
A
D
F
G
F
A
---
R
--
Y
L
H
----------
S
P
M
Y
M
A
P
E
V
I
M
S
--
Q
H
Y
D
A
K
-
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
-
F
--
Q
-------
A
N
--------
S
P
Q
D
-
L
R
M
F
--
Y
--
E
K
-
N
-
R
S
-----
L
M
----
P
---
S
I
P
R
E
T
S
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
449
Blastp_CBE
47.97
33%
-25
- C3 -
-
6QAV
6
ULK2_HUMAN
C:
[19-246]
--------------------
V
G
H
G
A
F
A
V
V
F
R
G
-
R
H
R
Q
K
T
D
----
W
-
E
V
A
I
K
S
I
--
N
---
K
K
--
N
--
L
--
S
--
K
---
S
--
Q
--
I
L
---
L
G
--
K
-------
E
I
K
I
L
K
E
L
---
Q
H
E
N
I
V
A
L
-
Y
D
V
Q
E
L
P
N
S
V
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
Q
A
K
G
T
L
S
E
D
T
I
R
V
F
L
H
Q
-
I
A
A
A
M
R
I
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
----
Y
A
---
N
RRKSSVSGI
R
-----
I
--
K
I
A
D
F
G
F
A
---
R
--
Y
L
H
S
N
M
M
A
A
D
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
S
--
Q
H
Y
D
A
K
-
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
-
F
--
Q
-------
A
N
--------
S
P
Q
D
-
L
R
M
F
--
Y
--
E
K
-
N
-
R
S
-----
L
M
----
P
---
S
I
P
R
E
T
S
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
47.67
33%
-27
- C3 -
-
6QAV
5
ULK2_HUMAN
A:
[19-246]
--------------------
V
G
H
G
A
F
A
V
V
F
R
G
-
R
H
R
Q
K
T
D
----
W
-
E
V
A
I
K
S
I
--
N
---
K
K
--
N
--
L
--
S
--
K
---
S
--
Q
--
I
L
---
L
G
--
K
-------
E
I
K
I
L
K
E
L
---
Q
H
E
N
I
V
A
L
-
Y
D
V
Q
E
L
P
N
S
V
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
Q
A
K
G
T
L
S
E
D
T
I
R
V
F
L
H
Q
-
I
A
A
A
M
R
I
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
----
Y
A
---
N
RRKSSVSGI
R
-----
I
--
K
I
A
D
F
G
F
A
---
R
--
Y
L
H
S
N
M
M
A
A
D
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
S
--
Q
H
Y
D
A
K
-
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
-
F
--
Q
-------
A
N
--------
S
P
Q
D
-
L
R
M
F
--
Y
--
E
K
-
N
-
R
S
-----
L
M
----
P
---
S
I
P
R
E
T
S
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
47.62
33%
-37
- C3 -
-
6QAU
4
ULK2_HUMAN
B:
[19-246]
--------------------
V
G
H
G
A
F
A
V
V
F
R
G
-
R
H
R
Q
K
T
D
----
W
-
E
V
A
I
K
S
I
--
N
---
K
K
--
N
--
L
--
S
--
K
---
S
--
Q
--
I
L
---
L
G
--
K
-------
E
I
K
I
L
K
E
L
---
Q
H
E
N
I
V
A
L
-
Y
D
V
Q
E
L
P
N
S
V
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
Q
A
K
G
T
L
S
E
D
T
I
R
V
F
L
H
Q
-
I
A
A
A
M
R
I
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
----
Y
A
---
N
RRKSSVSGI
R
-----
I
--
K
I
A
D
F
G
F
A
---
R
--
Y
L
H
----------
S
P
M
Y
M
A
P
E
V
I
M
S
--
Q
H
Y
D
A
K
-
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
-
F
--
Q
-------
A
N
--------
S
P
Q
D
-
L
R
M
F
--
Y
--
E
K
-
N
-
R
S
-----
L
M
----
P
---
S
I
P
R
E
T
S
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
456
Blastp_CBE
47.58
33%
-44
- C3 -
-
6QAT
2
ULK2_HUMAN
C:
[19-246]
--------------------
V
G
H
G
A
F
A
V
V
F
R
G
-
R
H
R
Q
K
T
D
----
W
-
E
V
A
I
K
S
I
--
N
---
K
K
--
N
--
L
--
S
--
K
---
S
--
Q
--
I
L
---
L
G
--
K
-------
E
I
K
I
L
K
E
L
---
Q
H
E
N
I
V
A
L
-
Y
D
V
Q
E
L
P
N
S
V
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
Q
A
K
G
T
L
S
E
D
T
I
R
V
F
L
H
Q
-
I
A
A
A
M
R
I
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
----
Y
A
----SGI------
R
-----
I
--
K
I
A
D
F
G
F
A
---
R
--
Y
L
H
----------
S
P
M
Y
M
A
P
E
V
I
M
S
--
Q
H
Y
D
A
K
-
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
-
F
--
Q
-------
A
N
--------
S
P
Q
D
-
L
R
M
F
--
Y
--
E
K
-
N
-
R
S
-----
L
M
----
P
---
S
I
P
R
E
T
S
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
47.37
38%
25
- C3 -
-
3LIJ
1
?
A:
[37-291]
---------
E
M
Y
Q
R
V
---
K
K
L
G
S
---
G
E
V
L
L
C
-
R
D
K
V
-
T
H
----
V
-
E
R
A
I
K
I
I
------
R
K
------------------
S
--
S
N
---
S
K
LL
E
-------
E
V
A
V
L
K
L
L
---
D
H
P
N
I
M
K
L
-
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
-
I
H
R
M
K
F
N
E
V
D
A
A
V
I
I
K
Q
-
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
SK--
E
K
---
D
---------
A
-----
L
I-
K
I
V
D
F
G
L
S
A
V
F
E
----
N
Q
K
K
M
K
E
R
L
-
G
T
A
Y
Y
I
A
P
E
V
L
R
K
--
K
--
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
-
F
--
G
G
---
Q
--
T
D
--------
Q
E
I
L
-
R
K
V
E
--
K
--
G
K
-
Y
-
T
F
-----
D
S
----
P
E--
W
K
N
V
S
E
G
A
K
D
------
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
-----
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
359
Blastp_CBE
47.30
32%
-24
- C3 -
-
6BAB
1
KCC2D_MOUSE
D:
[10-272]
-------
F
T
D
E
Y
Q
L
F
---
E
E
L
G
K
G
A
F
S
V
V
R
R
C
-
M
K
I
P
-
T
G
----
Q
-
E
Y
A
A
K
I
I
--
N
---
T
K
--
K
L-
S
--
A
--
R
---
D
--
H
--
Q
K
---
L
E
--
R
-------
E
A
R
I
C
R
L
L
---
K
H
P
N
I
V
R
L
-
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
-
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
-
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
----
S
K
---
S
---------
K
GAA--
V
--
K
L
A
D
F
G
L
A
--
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-
R
--
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
-------
D
--------
Q
H
R
L
-
Y
Q
Q
I
--
K
---
A
-
G
-
A
Y
-----
D
F
----
P
SPE
W
D
T
V
T
P
E
A
K
D
------
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
----
A
L
K
H
P
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
450
Blastp_CBE
46.67
33%
-23
- C3 -
-
6QAV
7
ULK2_HUMAN
B:
[19-246]
--------------------
V
G
H
G
A
F
A
V
V
F
R
G
-
R
H
R
Q
K
T
D
----
W
-
E
V
A
I
K
S
I
--
N
---
K
K
--
N
--
L
--
S
--
K
---
S
--
Q
--
I
L
---
L
G
--
K
-------
E
I
K
I
L
K
E
L
---
Q
H
E
N
I
V
A
L
-
Y
D
V
Q
E
L
P
N
S
V
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
Q
A
K
G
T
L
S
E
D
T
I
R
V
F
L
H
Q
-
I
A
A
A
M
R
I
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
----
Y
A
----SVSGI----
R
-----
I
--
K
I
A
D
F
G
F
A
---
R
--
Y
L
H
S
N
M
M
A
A
D
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
S
--
Q
H
Y
D
A
K
-
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
-
F
--
Q
-------
A
N
--------
S
P
Q
D
-
L
R
M
F
--
Y
--
E
K
-
N
-
R
S
-----
L
M
----
P
---
S
I
P
R
E
T
S
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
46.13
33%
-48
- C3 -
-
6QAU
5
ULK2_HUMAN
C:
[19-246]
--------------------
V
G
H
G
A
F
A
V
V
F
R
G
-
R
H
R
Q
K
T
D
----
W
-
E
V
A
I
K
S
I
--
N
---
K
----------------------
I
L
---
L
G
--
K
-------
E
I
K
I
L
K
E
L
---
Q
H
E
N
I
V
A
L
-
Y
D
V
Q
E
L
P
N
S
V
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
Q
A
K
G
T
L
S
E
D
T
I
R
V
F
L
H
Q
-
I
A
A
A
M
R
I
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
----
Y
A
---
N
RRKSSVSGI
R
-----
I
--
K
I
A
D
F
G
F
A
---
R
--
Y
L
H
S
---------
S
P
M
Y
M
A
P
E
V
I
M
S
--
Q
H
Y
D
A
K
-
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
-
F
--
Q
-------------------------
F
--
Y
--
E
K
-
N
-
R
S
-----
L
M
----
P
---
S
I
P
R
E
T
S
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
358
Blastp_CBE
45.95
33%
-2
- C3 -
-
3KN5
1
KS6A5_HUMAN
A:
[5-273]
---
P
---
F
Y
Q
H
Y
D
L
D
LKD
K
P
L
G
E
G
S
F
S
I
C
R
K
C
-
V
H
K
K
-
S
N
----
Q
-
A
F
A
V
K
I
I
--
S
---
K
R
--
M
--
E
--
A
-------------
N
---
T
Q
--
K
-------
E
I
T
A
L
K
L
C
E--
G
H
P
N
I
V
K
L
-
H
E
V
F
H
D
Q
L
H
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
-
K
K
K
K
H
F
S
E
T
E
A
S
Y
I
M
R
K
-
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
---
F
T--
D
-------------------------
L
EI
K
I
I
D
F
G
F
A
R
L
K
P
--
P
--------------------------
N
G
Y
-
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
-
F
--
Q
------------------
C
T
S
-
A
V
E
I
MK
K
--
I
K
-
K
-
G
D
-----
F
S
FEGE
A
---
W
K
N
V
S
Q
E
A
K
D
------
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
-----
K
M
S
G
----
L
R
Y
N
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
45.80
33%
4
- C3 -
-
3KN5
1
B:
[5-273]
---
P
---
F
Y
Q
H
Y
D
L
D
LKD
K
P
L
G
E
G
S
F
S
I
C
R
K
C
-
V
H
K
K
-
S
N
----
Q
-
A
F
A
V
K
I
I
--
S
---
K
R
--
M
--
E
--
A
-------------
N
---
T
Q
--
K
-------
E
I
T
A
L
K
L
C
E--
G
H
P
N
I
V
K
L
-
H
E
V
F
H
D
Q
L
H
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
-
K
K
K
K
H
F
S
E
T
E
A
S
Y
I
M
R
K
-
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
---
F
T--
D
-------------------------
L
EI
K
I
I
D
F
G
F
A
R
L
K
P
--
P
--------------------------
N
G
Y
-
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
-
F
--
Q
S
---
H
DR
S
L
--------
T
C
T
S
-
A
V
E
I
MK
K
--
I
K
-
K
-
G
D
-----
F
S
FEGE
A
---
W
K
N
V
S
Q
E
A
K
D
------
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
-----
K
M
S
G
----
L
R
Y
N
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
45.16
32%
-32
- C3 -
-
4B8M
1
AUKBA_XENLA
A:
[14-219]
--------
I
D
D
F
D
I
G
---
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
-
N
K
----
F
-
I
M
A
L
K
V
L
------
F
K
--
S
--
Q
--
L
--
E
KEG
V
--
E
--
H
Q
---
L
R
--
R
-------
E
I
E
I
Q
S
H
L
---
R
H
P
N
I
L
R
M
-
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
-
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
-
L
A
D
A
L
H
Y
C
H
E
R
K
V
I
H
R
D
I
K
P
E
N
L
L
---
M
---
G
----
Y
K
---
G
---------
E
-----
L
--
K
I
A
D
F
G
W
S
V
-------
H
A
P
S
L
R
R
R
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
K
T
-
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
-
F
--
D
S
---
P
--
S
H
--------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
45.03
33%
-43
- C3 -
-
4WNO
1
ULK1_HUMAN
A:
[26-245]
--------------------
I
G
H
G
A
F
A
V
V
F
K
G
-
R
H
R
A
-
A
H
----
D
L
E
V
A
V
K
C
I
--
N
---
K
K
--
N
--
L
--
A
--
K
---
S
--
Q
--
T
L
---
L
G
--
K
-------
E
I
K
I
L
K
E
L
---
K
H
E
N
I
V
A
L
-
Y
D
F
Q
E
M
A
N
S
V
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
H
A
M
R
T
L
S
E
D
T
I
R
L
F
L
Q
Q
-
I
A
G
A
M
R
L
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
NPAG
R
R
---
A
---------
N
PNSIR
V
--
K
I
A
D
F
G
F
A
R
Y
L
Q
--
S
N
----
M
M
A
A
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
S
--
Q
H
Y
D
G
K
-
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
-
F
--
Q
-------
A
S
--------
S
P
Q
D
-
L
R
L
F
--
Y
--
E
K
-
N
-
K
T
-----
L
V
----
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
400
Blastp_CBE
44.93
33%
3
- C3 -
-
4MVF
2
CDPK2_PLAFK
A:
[63-326]
------------------
E
K
L
G
Q
G
T
Y
G
C
V
Y
K
G
-
I
D
K
V
-
T
N
----
Q
-
L
Y
A
I
K
---------
E
--
E
--
K
--
K
--
D
---
R
--
L
--
K
N
---
I
N
--
R
FFQ----
E
I
E
I
M
K
K
L
---
D
H
P
N
I
V
K
L
-
Y
E
T
Y
E
N
D
N
Y
I
Y
L
I
M
E
L
C
S
G
R
E
L
F
D
S
I
-
I
E
N
G
S
F
T
E
K
N
A
A
T
I
M
K
Q
-
I
F
S
A
I
F
Y
L
H
S
L
N
I
V
H
R
D
L
K
P
E
N
F
L
---
F
---
Q
----
S
E
---
N
---------
K
DSL--
L
--
K
I
I
D
F
G
L
S
K
N
L
------------------------------
K
--
Y
D
K
K
C
D
I
W
S
S
G
V
I
M
Y
T
L
L
C
G
Y
P
P
-
F
--
Y
----------------------------------
C
-
F
Y
-----
E
N
----
D
---
W
G
S
I
S
S
D
A
K
N
------
L
I
T
K
L
L
T
Y
N
P
N
E
R
C
-----
T
I
E
E
----
A
L
N
H
P
W
----
I
T
----
Q
M
T
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
44.88
33%
-46
- C3 -
-
4WNP
1
ULK1_HUMAN
D:
[26-245]
--------------------
I
G
H
G
A
F
A
V
V
F
K
G
-
R
H
R
A
-
A
H
----
D
L
E
V
A
V
K
C
I
--
N
---
K
K
--
N
--
L
--
A
--
K
---
S
--
Q
--
T
L
---
L
G
--
K
-------
E
I
K
I
L
K
E
L
---
K
H
E
N
I
V
A
L
-
Y
D
F
Q
E
M
A
N
S
V
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
H
A
M
R
T
L
S
E
D
T
I
R
L
F
L
Q
Q
-
I
A
G
A
M
R
L
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
NPAG
R
R
---
A
---------
N
PNSIR
V
--
K
I
A
D
F
G
F
A
R
Y
L
Q
--
S
N
----
M
M
A
A
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
S
--
Q
H
Y
D
G
K
-
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
-
F
--
Q
-------
A
S
--------
S
P
Q
D
-
L
R
L
F
--
Y
--
E
K
-
N
-
K
T
-----
L
V
----
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
473
Blastp_CBE
44.60
33%
-14
- C3 -
-
3AMA
1
KAPCA_HUMAN
A:
[41-249]
--------
L
D
Q
F
E
R
I
---
R
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
Q
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
-
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
K
V
A
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
44.58
33%
-43
- C3 -
-
4WNP
3
ULK1_HUMAN
A:
[26-245]
--------------------
I
G
H
G
A
F
A
V
V
F
K
G
-
R
H
R
A
-
A
H
----
D
L
E
V
A
V
K
C
I
--
N
---
K
K
--
N
--
L
--
A
--
K
---
S
--
Q
--
T
L
---
L
G
--
K
-------
E
I
K
I
L
K
E
L
---
K
H
E
N
I
V
A
L
-
Y
D
F
Q
E
M
A
N
S
V
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
H
A
M
R
T
L
S
E
D
T
I
R
L
F
L
Q
Q
-
I
A
G
A
M
R
L
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
NPAG
R
R
---
A
---------
N
PNSIR
V
--
K
I
A
D
F
G
F
A
R
Y
L
Q
--
S
N
----
M
M
A
A
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
S
--
Q
H
Y
D
G
K
-
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
-
F
--
Q
-------
A
S
--------
S
P
Q
D
-
L
R
L
F
--
Y
--
E
K
-
N
-
K
T
-----
L
V
----
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
44.45
33%
-16
- C3 -
-
6QAV
5
ULK2_HUMAN
D:
[19-273]
--------------------
V
G
H
G
A
F
A
V
V
F
R
G
-
R
H
R
Q
K
T
D
----
W
-
E
V
A
I
K
S
I
--
N
---
K
K
--
N
--
L
--
S
--
K
---
S
--
Q
--
I
L
---
L
G
--
K
-------
E
I
K
I
L
K
E
L
---
Q
H
E
N
I
V
A
L
-
Y
D
V
Q
E
L
P
N
S
V
F
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
Q
A
K
G
T
L
S
E
D
T
I
R
V
F
L
H
Q
-
I
A
A
A
M
R
I
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
----
Y
A
---
N
RRKSSVSGI
R
-----
I
--
K
I
A
D
F
G
F
A
---
R
--
Y
L
H
S
N
M
M
A
A
D
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
S
--
Q
H
Y
D
A
K
-
A
D
L
W
S
I
G
T
V
I
Y
Q
C
L
V
G
K
P
P
-
F
--
Q
-------
A
N
--------
S
P
Q
D
-
L
R
M
F
--
Y
--
E
K
-
N
-
R
S
-----
L
M
----
P
---
S
I
P
R
E
T
S
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
44.28
33%
-42
- C3 -
-
4WNP
2
ULK1_HUMAN
B:
[26-245]
--------------------
I
G
H
G
A
F
A
V
V
F
K
G
-
R
H
R
A
-
A
H
----
D
L
E
V
A
V
K
C
I
--
N
---
K
K
--
N
--
L
--
A
--
K
---
S
--
Q
--
T
L
---
L
G
--
K
-------
E
I
K
I
L
K
E
L
---
K
H
E
N
I
V
A
L
-
Y
D
F
Q
E
M
A
N
S
V
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
H
A
M
R
T
L
S
E
D
T
I
R
L
F
L
Q
Q
-
I
A
G
A
M
R
L
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
NPAG
R
R
---
A
---------
N
PNSIR
V
--
K
I
A
D
F
G
F
A
R
Y
L
Q
--
S
N
----
M
M
A
A
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
S
--
Q
H
Y
D
G
K
-
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
-
F
--
Q
-------
A
S
--------
S
P
Q
D
-
L
R
L
F
--
Y
--
E
K
-
N
-
K
T
-----
L
V
----
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
44.28
32%
-32
- C3 -
-
3ZTX
1
AUKBA_XENLA
A:
[13-218]
--------
I
D
D
F
D
I
G
---
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
-
N
K
----
F
-
I
M
A
L
K
V
L
------
F
K
--
S
--
Q
--
L
--
E
KEG
V
--
E
--
H
Q
---
L
R
--
R
-------
E
I
E
I
Q
S
H
L
---
R
H
P
N
I
L
R
M
-
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
-
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
-
L
A
D
A
L
H
Y
C
H
E
R
K
V
I
H
R
D
I
K
P
E
N
L
L
---
M
---
G
----
Y
K
---
G
---------
E
-----
L
--
K
I
A
D
F
G
W
S
V
-------
H
A
P
S
L
R
R
R
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
K
T
-
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
-
F
--
D
S
---
P
--
S
H
--------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
44.24
32%
-32
- C3 -
-
2VGO
1
AUKBA_XENLA
A:
[13-218]
--------
I
D
D
F
D
I
G
---
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
-
N
K
----
F
-
I
M
A
L
K
V
L
------
F
K
--
S
--
Q
--
L
--
E
KEG
V
--
E
--
H
Q
---
L
R
--
R
-------
E
I
E
I
Q
S
H
L
---
R
H
P
N
I
L
R
M
-
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
-
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
-
L
A
D
A
L
H
Y
C
H
E
R
K
V
I
H
R
D
I
K
P
E
N
L
L
---
M
---
G
----
Y
K
---
G
---------
E
-----
L
--
K
I
A
D
F
G
W
S
V
-------
H
A
P
S
L
R
R
R
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
K
T
-
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
-
F
--
D
S
---
P
--
S
H
--------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
43.82
33%
-18
- C3 -
-
3AMB
1
KAPCA_HUMAN
A:
[41-249]
--------
L
D
Q
F
E
R
I
---
R
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
Q
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
-
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
K
V
A
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
461
Blastp_CBE
43.78
33%
-40
- C3 -
-
5CI7
4
ULK1_HUMAN
A:
[26-245]
--------------------
I
G
H
G
A
F
A
V
V
F
K
G
-
R
H
R
A
-
A
H
----
D
L
E
V
A
V
K
C
I
--
N
---
K
K
--
N
--
L
--
A
--
K
---
S
--
Q
--
T
L
---
L
G
--
K
-------
E
I
K
I
L
K
E
L
---
K
H
E
N
I
V
A
L
-
Y
D
F
Q
E
M
A
N
S
V
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
H
A
M
R
T
L
S
E
D
T
I
R
L
F
L
Q
Q
-
I
A
G
A
M
R
L
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
NPAG
R
R
---
A
---------
N
PNSIR
V
--
K
I
A
D
F
G
F
A
R
Y
L
Q
--
S
N
----
M
M
A
A
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
S
--
Q
H
Y
D
G
K
-
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
-
F
--
Q
-------
A
S
--------
S
P
Q
D
-
L
R
L
F
--
Y
--
E
K
-
N
-
K
T
-----
L
V
----
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
43.77
32%
-12
- C3 -
-
2GU8
1
KAPCA_HUMAN
A:
[27-230]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
E
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
43.66
33%
-39
- C3 -
-
4WNP
1
ULK1_HUMAN
C:
[26-245]
--------------------
I
G
H
G
A
F
A
V
V
F
K
G
-
R
H
R
A
-
A
H
----
D
L
E
V
A
V
K
C
I
--
N
---
K
K
--
N
--
L
--
A
--
K
---
S
--
Q
--
T
L
---
L
G
--
K
-------
E
I
K
I
L
K
E
L
---
K
H
E
N
I
V
A
L
-
Y
D
F
Q
E
M
A
N
S
V
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
H
A
M
R
T
L
S
E
D
T
I
R
L
F
L
Q
Q
-
I
A
G
A
M
R
L
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
NPAG
R
R
---
A
---------
N
PNSIR
V
--
K
I
A
D
F
G
F
A
R
Y
L
Q
--
S
N
----
M
M
A
A
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
S
--
Q
H
Y
D
G
K
-
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
-
F
--
Q
-------
A
S
--------
S
P
Q
D
-
L
R
L
F
--
Y
--
E
K
-
N
-
K
T
-----
L
V
----
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
43.51
32%
-27
- C3 -
-
4B8M
1
AUKBA_XENLA
B:
[14-219]
--------
I
D
D
F
D
I
G
---
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
-
N
K
----
F
-
I
M
A
L
K
V
L
------
F
K
--
S
--
Q
--
L
--
E
KEG
V
--
E
--
H
Q
---
L
R
--
R
-------
E
I
E
I
Q
S
H
L
---
R
H
P
N
I
L
R
M
-
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
-
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
-
L
A
D
A
L
H
Y
C
H
E
R
K
V
I
H
R
D
I
K
P
E
N
L
L
---
M
---
G
----
Y
K
---
G
---------
E
-----
L
--
K
I
A
D
F
G
W
S
V
-------
H
A
P
S
L
R
R
R
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
K
T
-
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
-
F
--
D
S
---
P
--
S
H
--------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
43.38
32%
5
- C3 -
-
2Z7S
1
KS6A1_HUMAN
A:
[30-290]
-----------
F
E
L
L
---
K
V
L
G
Q
G
S
F
G
K
V
F
L
--
V
R
K
V
-
T
R
PDSG
H
-
L
Y
A
M
K
V
L
--
K
----------------------------------------------
I
L
A
D
V
---
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
-
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
-
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
-
L
A
L
G
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
---
L
---
D
----
E
E
---
G
---------
H
-----
I
--
K
L
T
D
F
G
L
S
K
--
E
--------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
--
Q
G
-
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
-
F
---
Q
---
G
--
K
D
--------
R
K
E
T
-
M
T
L
I
--
L
--
K
A
-
K
-
L
G
-----
M
P
----
Q
---
F
--
L
S
T
E
A
Q
S
------
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G----
S
G
P
D
GAEE
I
K
R
H
V
F
----
Y
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
418
Blastp_CBE
43.16
32%
-2
- C3 -
-
2Z7Q
1
KS6A1_HUMAN
A:
[30-290]
-----------
F
E
L
L
---
K
V
L
G
Q
G
S
F
G
K
V
F
L
--
V
R
K
V
-
T
R
PDSG
H
-
L
Y
A
M
K
V
L
-------------------------------------------------
I
L
A
D
V
---
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
-
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
-
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
-
L
A
L
G
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
---
L
---
D
----
E
E
---
G
---------
H
-----
I
--
K
L
T
D
F
G
L
S
K
--
E
--------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
--
Q
G
-
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
-
F
---
Q
---
G
--
K
D
--------
R
K
E
T
-
M
T
L
I
--
L
--
K
A
-
K
-
L
G
-----
M
P
----
Q
---
F
--
L
S
T
E
A
Q
S
------
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G----
S
G
P
D
GAEE
I
K
R
H
V
F
----
Y
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
42.98
33%
-19
- C3 -
-
2BFY
1
AUKBA_XENLA
B:
[13-218]
--------
I
D
D
F
D
I
V
---
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
-
N
K
----
F
-
I
M
A
L
K
V
L
------
F
K
--
S
--
Q
--
L
--
E
KEG
V
--
E
--
H
Q
---
L
R
--
R
-------
E
I
E
I
Q
S
H
L
---
R
H
P
N
I
L
R
M
-
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
-
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
-
L
A
D
A
L
H
Y
C
H
E
R
K
V
I
H
R
D
I
K
P
E
N
L
L
---
M
---
G
----
Y
K
---
G
---------
E
-----
L
--
K
I
A
D
F
G
W
S
V
-------
H
A
P
S
L
R
R
R
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
K
T
-
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
-
F
--
D
S
---
P
--
S
H
--------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
42.72
32%
-25
- C3 -
-
3ZTX
1
AUKBA_XENLA
B:
[13-218]
--------
I
D
D
F
D
I
G
---
R
P
L
-----
G
N
V
Y
L
A
-
R
E
K
Q
-
N
K
----
F
-
I
M
A
L
K
V
L
------
F
K
--
S
--
Q
--
L
--
E
KEG
V
--
E
--
H
Q
---
L
R
--
R
-------
E
I
E
I
Q
S
H
L
---
R
H
P
N
I
L
R
M
-
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
-
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
-
L
A
D
A
L
H
Y
C
H
E
R
K
V
I
H
R
D
I
K
P
E
N
L
L
---
M
---
G
----
Y
K
---
G
---------
E
-----
L
--
K
I
A
D
F
G
W
S
V
-------
H
A
P
S
L
R
R
R
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
K
T
-
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
-
F
--
D
S
---
P
--
S
H
--------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
536
Blastp_CBE
42.57
33%
-21
- C3 -
-
6EM6
1
KAPCA_CRIGR
A:
[43-246]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
535
Blastp_CBE
42.57
33%
-23
- C3 -
-
6EMA
2
KAPCA_CRIGR
A:
[43-246]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
42.35
33%
-19
- C3 -
-
4B8L
1
AUKBA_XENLA
A:
[14-219]
--------
I
D
D
F
D
I
G
---
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
-
N
K
----
F
-
I
M
A
L
K
V
L
------
F
K
--
S
--
Q
--
L
--
E
KEG
V
--
E
--
H
Q
---
L
R
--
R
-------
E
I
E
I
Q
S
H
L
---
R
H
P
N
I
L
R
M
-
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
-
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
-
L
A
D
A
L
H
Y
C
H
E
R
K
V
I
H
R
D
I
K
P
E
N
L
L
---
M
---
G
----
Y
K
---
G
---------
E
-----
L
--
K
I
A
D
F
----------------------
T
L
D
Y
L
P
P
E
M
I
E
G
--
K
T
-
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
-
F
--
D
S
---
P
--
S
H
--------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
42.33
34%
-16
- C3 -
-
6FRX
1
KAPCA_HUMAN
A:
[41-249]
--------
L
D
Q
F
E
R
I
---
R
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
Q
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
K
V
A
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
549
Blastp_CBE
42.12
33%
-20
- C3 -
-
5O0E
2
KAPCA_CRIGR
A:
[43-246]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
542
Blastp_CBE
42.12
33%
-21
- C3 -
-
5OUC
2
KAPCA_CRIGR
A:
[43-246]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
42.09
33%
-22
- C3 -
-
4DH7
1
KAPCA_MOUSE
A:
[40-243]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
42.03
32%
7
- C3 -
-
2Z7R
1
KS6A1_HUMAN
A:
[30-290]
-----------
F
E
L
L
---
K
V
L
G
Q
G
S
F
G
K
V
F
L
--
V
R
K
V
-
T
R
PDSG
H
-
L
Y
A
M
K
V
L
--
K
----
K
--
A
--
T
--
L
--
K
---
V
-------------------------
I
L
A
D
V
---
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
-
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
-
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
-
L
A
L
G
L
D
H
L
H
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
---
L
---
D
----
E
E
---
G
---------
H
-----
I
--
K
L
T
D
F
G
L
S
K
--
E
--------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
--
Q
G
-
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
-
F
---
Q
---
G
--
K
D
--------
R
K
E
T
-
M
T
L
I
--
L
--
K
A
-
K
-
L
G
-----
M
P
----
Q
---
F
--
L
S
T
E
A
Q
S
------
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G----
S
G
P
D
GAEE
I
K
R
H
V
F
----
Y
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
499
Blastp_CBE
42.01
33%
-23
- C3 -
-
3X2U
1
KAPCA_MOUSE
A:
[47-250]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
502
Blastp_CBE
41.96
33%
-23
- C3 -
-
4XW5
1
KAPCA_MOUSE
A:
[46-249]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
538
Blastp_CBE
41.90
33%
-18
- C3 -
-
6EH3
1
KAPCA_CRIGR
A:
[43-246]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
518
Blastp_CBE
41.89
33%
-24
- C3 -
-
6EM7
4
KAPCA_CRIGR
A:
[43-246]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
521
Blastp_CBE
41.81
33%
-23
- C3 -
-
4DFX
5
KAPCA_MOUSE
E:
[40-243]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
509
Blastp_CBE
41.77
33%
-22
- C3 -
-
4IAK
1
KAPCA_MOUSE
A:
[46-249]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
41.59
34%
-19
- C3 -
-
5N23
1
KAPCA_HUMAN
A:
[41-251]
--------
L
D
Q
F
E
R
I
---
R
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
Q
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
K
V
A
D
F
G
F
A
K
--
R
--
V
K
G
R
T
P
W
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
513
Blastp_CBE
41.54
33%
-18
- C3 -
-
4IAC
1
KAPCA_MOUSE
A:
[46-249]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
491
Blastp_CBE
41.54
33%
-21
- C3 -
-
4DG0
2
KAPCA_MOUSE
E:
[40-243]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
547
Blastp_CBE
41.52
33%
-18
- C3 -
-
5OK3
1
KAPCA_CRIGR
A:
[43-246]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
512
Blastp_CBE
41.45
33%
-18
- C3 -
-
4IAD
1
KAPCA_MOUSE
A:
[46-249]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
484
Blastp_CBE
41.43
33%
-22
- C3 -
-
4HPU
2
KAPCA_MOUSE
E:
[40-243]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
516
Blastp_CBE
41.41
33%
-19
- C3 -
-
5NW8
2
KAPCA_CRIGR
A:
[41-244]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
41.43
33%
-19
- C3 -
-
5JR7
1
KAPCA_MOUSE
C:
[40-243]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
482
Blastp_CBE
41.41
33%
-18
- C3 -
-
5JR7
1
KAPCA_MOUSE
A:
[40-243]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
522
Blastp_CBE
41.35
33%
-19
- C3 -
-
4DG3
1
KAPCA_MOUSE
E:
[61-264]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
41.30
33%
-18
- C3 -
-
4XW6
1
KAPCA_MOUSE
A:
[46-249]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
546
Blastp_CBE
41.25
33%
-16
- C3 -
-
5OL3
2
KAPCA_CRIGR
A:
[43-246]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
534
Blastp_CBE
41.22
33%
-20
- C3 -
-
6EMB
1
KAPCA_CRIGR
A:
[43-246]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
41.21
33%
-21
- C3 -
-
6I2A
1
KAPCA_CRIGR
A:
[43-246]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
506
Blastp_CBE
41.19
33%
-20
- C3 -
-
4IB0
1
KAPCA_MOUSE
A:
[46-249]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
41.09
33%
-18
- C3 -
-
2QCS
5
KAPCA_MOUSE
A:
[40-243]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
531
Blastp_CBE
41.04
33%
-18
- C3 -
-
6ERT
1
KAPCA_CRIGR
A:
[43-246]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
41.01
33%
-20
- C3 -
-
4IAF
1
KAPCA_MOUSE
A:
[46-249]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
40.97
33%
-18
- C3 -
-
4IB1
1
KAPCA_MOUSE
A:
[46-249]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
545
Blastp_CBE
40.96
33%
-13
- C3 -
-
5OT3
3
KAPCA_CRIGR
A:
[43-246]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
497
Blastp_CBE
40.90
33%
-22
- C3 -
-
3X2W
1
KAPCA_MOUSE
A:
[47-250]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
40.88
33%
-17
- C3 -
-
4IB3
1
KAPCA_MOUSE
A:
[46-249]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
528
Blastp_CBE
40.85
33%
-21
- C3 -
-
6ESA
4
KAPCA_CRIGR
A:
[43-246]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
40.81
33%
-18
- C3 -
-
4IAZ
1
KAPCA_MOUSE
A:
[46-249]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
496
Blastp_CBE
40.80
33%
-20
- C3 -
-
3PVB
1
KAPCA_MOUSE
A:
[35-238]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
523
Blastp_CBE
40.79
33%
-14
- C3 -
-
6I2H
1
?
A:
[43-246]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
40.77
33%
-22
- C3 -
-
3X2V
1
KAPCA_MOUSE
A:
[47-250]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
548
Blastp_CBE
40.73
33%
-15
- C3 -
-
5O5M
1
KAPCA_CRIGR
A:
[43-248]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
508
Blastp_CBE
40.74
33%
-18
- C3 -
-
4IAY
1
KAPCA_MOUSE
A:
[46-249]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
526
Blastp_CBE
40.73
33%
-17
- C3 -
-
6I2B
2
KAPCA_CRIGR
A:
[43-248]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
510
Blastp_CBE
40.72
33%
-17
- C3 -
-
4IAI
2
KAPCA_MOUSE
A:
[46-249]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
544
Blastp_CBE
40.71
33%
-18
- C3 -
-
5OTG
1
KAPCA_CRIGR
A:
[43-246]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
40.65
33%
-21
- C3 -
-
1L3R
3
KAPCA_MOUSE
E:
[40-243]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
550
Blastp_CBE
40.63
33%
-14
- C3 -
-
5NTJ
2
KAPCA_CRIGR
A:
[43-249]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
489
Blastp_CBE
40.57
33%
-23
- C3 -
-
4DH1
1
KAPCA_MOUSE
A:
[40-243]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
40.52
33%
-20
- C3 -
-
4DH8
1
KAPCA_MOUSE
A:
[40-243]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
40.49
33%
-21
- C3 -
-
4X6R
4
KAPCA_MOUSE
A:
[40-243]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
552
Blastp_CBE
40.42
33%
-18
- C3 -
-
5N3S
5
KAPCA_CRIGR
A:
[43-246]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
540
Blastp_CBE
40.38
33%
-12
- C3 -
-
6EGW
1
KAPCA_CRIGR
A:
[43-248]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
479
Blastp_CBE
40.37
33%
-17
- C3 -
-
4O21
1
KAPCA_MOUSE
A:
[32-235]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
500
Blastp_CBE
40.36
33%
-21
- C3 -
-
6E21
1
KAPCA_MOUSE
A:
[46-249]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
537
Blastp_CBE
40.35
33%
-17
- C3 -
-
6EM2
2
KAPCA_CRIGR
A:
[43-246]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
40.28
33%
-15
- C3 -
-
4XW4
1
KAPCA_MOUSE
A:
[46-249]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
533
Blastp_CBE
40.18
33%
-15
- C3 -
-
6EMD
1
KAPCA_CRIGR
A:
[43-246]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
525
Blastp_CBE
40.18
33%
-14
- C3 -
-
6I2C
1
KAPCA_CRIGR
A:
[43-246]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
--
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
524
Blastp_CBE
40.16
33%
-16
- C3 -
-
6I2D
1
KAPCA_CRIGR
A:
[43-246]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
40.15
33%
-14
- C3 -
-
6ERS
1
KAPCA_CRIGR
A:
[43-246]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
G
--
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
487
Blastp_CBE
39.94
33%
-17
- C3 -
-
4DH5
1
KAPCA_MOUSE
A:
[40-243]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
529
Blastp_CBE
39.90
33%
-28
- C3 -
-
6ERW
2
KAPCA_CRIGR
A:
[43-246]
--------
L
D
H
F
D
R
I
---
K
T
L
G
T
---
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
539
Blastp_CBE
39.65
33%
-33
- C3 -
-
6EH2
2
KAPCA_CRIGR
A:
[43-251]
--------
L
D
H
F
D
R
I
---
K
T
L
---
S
F
G
R
V
M
L
V
-
K
H
K
E
-
T
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
----
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
488
Blastp_CBE
39.36
33%
-19
- C3 -
-
4DH3
1
KAPCA_MOUSE
A:
[40-243]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
39.26
33%
-17
- C3 -
-
4WBB
1
KAPCA_MOUSE
B:
[40-243]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
38.62
33%
-13
- C3 -
-
3TNQ
1
KAPCA_MOUSE
B:
[40-243]
--------
L
D
Q
F
D
R
I
---
K
T
L
G
T
G
S
F
G
R
V
M
L
V
-
K
H
K
E
-
S
G
----
N
-
H
Y
A
M
K
I
L
--
D
---
K
Q
--
K
--
V
--
V
--
K
---
L
--
K
QI
E
H
---
T
L
--
N
-------
E
K
R
I
L
Q
A
V
---
N
F
P
F
L
V
K
L
-
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
-
R
-
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
-
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
----
Q
Q
---
G
---------
Y
-----
I
--
Q
V
T
D
F
G
F
A
K
--
R
--
V
K
G
R
T
W
L
T
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
--
K
G
Y
N
-
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
FA
D
Q
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
38.04
33%
-13
- C3 -
-
6QAS
7
ULK1_HUMAN
B:
[26-245]
--------------------
I
G
H
G
A
F
A
V
V
F
K
G
-
R
H
R
A
-
A
H
----
D
L
E
V
A
V
K
C
I
--
N
---
K
K
--
N
--
L
--
A
--
K
---
S
--
Q
--
T
L
---
L
G
--
K
-------
E
I
K
I
L
K
E
L
---
K
H
E
N
I
V
A
L
-
Y
D
F
Q
E
M
A
N
V
-
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
H
A
M
R
T
L
S
E
D
T
I
R
L
F
L
Q
Q
-
I
A
G
A
M
R
L
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
NPAG
R
R
---
A
---------
N
PNSIR
V
--
K
I
A
D
F
G
F
A
R
Y
L
Q
--
S
N
----
M
M
A
A
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
S
--
Q
H
Y
D
G
K
-
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
-
F
--
Q
-------
A
S
--------
S
P
Q
D
-
L
R
L
F
--
Y
--
E
K
-
N
-
K
T
-----
L
V
----
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
36.23
33%
-9
- C3 -
-
6QAS
14
ULK1_HUMAN
A:
[26-245]
--------------------
I
G
H
G
A
F
A
V
V
F
K
G
-
R
H
R
A
-
A
H
----
D
L
E
V
A
V
K
C
I
--
N
---
K
K
--
N
--
L
--
A
--
K
---
S
--
Q
--
T
L
---
L
G
--
K
-------
E
I
K
I
L
K
E
L
---
K
H
E
N
I
V
A
L
-
Y
D
F
Q
E
M
A
N
V
-
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
-
H
A
M
R
T
L
S
E
D
T
I
R
L
F
L
Q
Q
-
I
A
G
A
M
R
L
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
---
L
---
S
NPAG
R
R
---
A
---------
N
PNSIR
V
--
K
I
A
D
F
G
F
A
R
Y
L
Q
--
S
N
----
M
M
A
A
L
C
G
S
P
M
Y
M
A
P
E
V
I
M
S
--
Q
H
Y
D
G
K
-
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
-
F
--
Q
-------
A
S
--------
S
P
Q
D
-
L
R
L
F
--
Y
--
E
K
-
N
-
K
T
-----
L
V
----
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------