@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CLK2_HUMAN: (2020-09-07 )
MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR
Atome Classification :
(106 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220..--.....230.....----..240.......250....-...260.......270.......280--..-...--..290......-.300.....-..310......-----.320----------------.......330.......340.......350.......360.......370.......380......------.390.......400...---..-..410...-.--.-----.----.--420..-.----..--..--..--430-.---------.----------.---------.--------...----..440.-.---------------..---------..-----------..450.------......460.......470.......480.......490.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPHPRRYHSSERGSRG
S
Y
R
E
H
Y
R
S
R
K
H
K
R
R
RSRSWSSS
S
D
R
T
R
R
R
RREDS
Y
H
VRSRSSYDDRSSDR
R
V
Y
D
R
R
Y
CGSYRRNDYSRDRGDAYYDTDYRH
S
Y
E
YQREN
S
S
Y
R
S
Q
R
S
S
R
R
K
H
R
R
R
R
R
RSRTFSRSSSQHSSRRAKSVEDDAE
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
LGE
G
T
F
G
R
V
V
Q
C
V
D
HRRG
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
INEKDPDNK
N
--
L
C
V
Q
M
F
D
W
FDYHG----
H
M
C
I
S
F
E
L
LG
L
S
T
F
D
FLKD-NNYLPY
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H--DN-KLT--HTDLKPE
N
I
L
F
-VNSD
Y
E
L
T
Y
-NLEKK
R
D
E
R
S
V-----
K
S
T
A
----------------
V
R
V
V
DFGSATFDHEH
H
S
T
I
V
STRHYR
A
P
E
V
I
L
ELGWSQPC
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
QTHD
N
R
E
------
H
L
A
M
M
E
R
I
LGPI
P
S
R
M
I
---
R
K
-
T
R
K
Q
K
Y
F
Y-R--G-----R----L--D--WD-E----NT--SA--
G
R
--
Y
---
V
---------
R
----------
E
---------
N
--------
C
K
P
----
L
R
R
Y
-
L
-
T
---------------
S
E
---------
A
E
-----------
E
H
H
Q
L
F
------
D
L
I
E
S
M
L
EYEPAKRL
T
L
G
E
A
L
Q
H
P
F
F
A
R
LRAEP
P
N
KLWDSSRDISR
24
Blastp_CBE
97.19
100%
-133
- C1 -
-
6FYK
1
CLK2_HUMAN
C:
[4-352]
----------------------------------------------------------------------------------------------------------------------------------------
S
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
--
L
C
V
Q
M
F
D
W
F
D
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
D
Y
E
L
T
Y
-
N
L
E
K
K
R
D
E
R
S
V
-----
K
S
T
A
----------------
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
------
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
---
R
K
-
T
R
K
Q
K
Y
F
Y
-
R
--
G
-----
R
----
L
--
D
--
W
D
-
E
----
N
T
--
S
A
--
G
R
--
Y
---
V
---------
R
----------
E
---------
N
--------
C
K
P
----
L
R
R
Y
-
L
-
T
---------------
S
E
---------
A
E
-----------
E
H
H
Q
L
F
------
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
E
--------------
25
Blastp_CBE
96.95
100%
-129
- C1 -
-
6FYK
1
CLK2_HUMAN
B:
[4-352]
----------------------------------------------------------------------------------------------------------------------------------------
S
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
--
L
C
V
Q
M
F
D
W
F
D
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
D
Y
E
L
T
Y
-
N
L
E
K
K
R
D
E
R
S
V
-----
K
S
T
A
----------------
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
------
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
---
R
K
-
T
R
K
Q
K
Y
F
Y
-
R
--
G
-----
R
----
L
--
D
--
W
D
-
E
----
N
T
--
S
A
--
G
R
--
Y
---
V
---------
R
----------
E
---------
N
--------
C
K
P
----
L
R
R
Y
-
L
-
T
---------------
S
E
---------
A
E
-----------
E
H
H
Q
L
F
------
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
E
--------------
6
PsiBlast_PDB
96.91
100%
-143
- C1 -
-
5UNP
1
CLK2_HUMAN
A:
[13-356]
-------------------------------------------------------------------------------------------------------------------------------------------
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
--
L
C
V
Q
M
F
D
W
F
D
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
D
Y
E
L
T
Y
-
N
L
E
K
K
R
D
E
R
S
V
-----
K
S
T
A
----------------
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
------
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
---
R
K
-
T
R
K
Q
K
Y
F
Y
-
R
--
G
-----
R
----
L
--
D
--
W
D
-
E
----
N
T
--
S
A
--
G
R
--
Y
---
V
---------
R
----------
E
---------
N
--------
C
K
P
----
L
R
R
Y
-
L
-
T
---------------
S
E
---------
A
E
-----------
E
H
H
Q
L
F
------
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
----------------
23
Blastp_CBE
96.89
99%
-140
- C1 -
-
5UNP
1
CLK2_HUMAN
B:
[10-356]
----------------------------------------------------------------------------------------------------------------------------------------
S
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
--
L
C
V
Q
M
F
D
W
F
D
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
D
Y
E
L
T
Y
-
N
L
E
K
K
R
D
E
R
S
V
-----
K
S
T
A
----------------
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
------
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
---
R
K
-
T
R
K
Q
K
Y
F
Y
-
R
--
G
-----
R
----
L
--
D
--
W
D
-
E
----
N
T
--
S
A
--
G
R
--
Y
---
V
---------
R
----------
E
---------
N
--------
C
K
P
----
L
R
R
Y
-
L
-
T
---------------
S
E
---------
A
E
-----------
E
H
H
Q
L
F
------
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
----------------
4
PsiBlast_PDB
96.38
100%
-136
- C1 -
-
6FYK
1
CLK2_HUMAN
A:
[4-352]
----------------------------------------------------------------------------------------------------------------------------------------
S
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
--
L
C
V
Q
M
F
D
W
F
D
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
D
Y
E
L
T
Y
-
N
L
E
K
K
R
D
E
R
S
V
-----
K
S
T
A
----------------
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
------
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
---
R
K
-
T
R
K
Q
K
Y
F
Y
-
R
--
G
-----
R
----
L
--
D
--
W
D
-
E
----
N
T
--
S
A
--
G
R
--
Y
---
V
---------
R
----------
E
---------
N
--------
C
K
P
----
L
R
R
Y
-
L
-
T
---------------
S
E
---------
A
E
-----------
E
H
H
Q
L
F
------
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
E
--------------
22
Blastp_CBE
96.13
99%
-130
- C1 -
-
3NR9
1
CLK2_HUMAN
B:
[8-354]
---------------------------------------------------------------------------------------------------------------------------------------
S
S
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
--
L
C
V
Q
M
F
D
W
F
D
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
D
Y
E
L
T
Y
-
N
L
E
K
K
R
D
E
R
S
V
-----
K
S
T
A
----------------
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
------
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
---
R
K
-
T
R
K
Q
K
Y
F
Y
-
R
--
G
-----
R
----
L
--
D
--
W
D
-
E
----
N
T
--
S
A
--
G
R
--
Y
---
V
---------
R
----------
E
---------
N
--------
C
K
P
----
L
R
R
Y
-
L
-
T
---------------
S
E
---------
A
E
-----------
E
H
H
Q
L
F
------
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
-----------------
21
Blastp_CBE
95.65
99%
-130
- C1 -
-
3NR9
1
CLK2_HUMAN
C:
[9-355]
----------------------------------------------------------------------------------------------------------------------------------------
S
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
--
L
C
V
Q
M
F
D
W
F
D
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
D
Y
E
L
T
Y
-
N
L
E
K
K
R
D
E
R
S
V
-----
K
S
T
A
----------------
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
------
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
---
R
K
-
T
R
K
Q
K
Y
F
Y
-
R
--
G
-----
R
----
L
--
D
--
W
D
-
E
----
N
T
--
S
A
--
G
R
--
Y
---
V
---------
R
----------
E
---------
N
--------
C
K
P
----
L
R
R
Y
-
L
-
T
---------------
S
E
---------
A
E
-----------
E
H
H
Q
L
F
------
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
----------------
2
PsiBlast_PDB
95.60
99%
-136
- C1 -
-
3NR9
1
CLK2_HUMAN
A:
[9-356]
----------------------------------------------------------------------------------------------------------------------------------------
S
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
--
L
C
V
Q
M
F
D
W
F
D
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
D
Y
E
L
T
--------
D
E
R
S
V
-----
K
S
T
A
----------------
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
------
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
---
R
K
-
T
R
K
Q
K
Y
F
Y
-
R
--
G
-----
R
----
L
--
D
--
W
D
-
E
----
N
T
--
S
A
--
G
R
--
Y
---
V
---------
R
----------
E
---------
N
--------
C
K
P
----
L
R
R
Y
-
L
-
T
---------------
S
E
---------
A
E
-----------
E
H
H
Q
L
F
------
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
---------------
5
PsiBlast_PDB
94.97
100%
-135
- C1 -
-
6FYL
1
CLK2_HUMAN
A:
[11-350]
-----------------------------------------------------------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
--
L
C
V
Q
M
F
D
W
F
D
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
D
Y
E
L
T
Y
-
N
L
E
K
K
R
D
E
R
S
V
-----
K
S
T
A
----------------
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
------
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
---
R
K
-
T
R
K
Q
K
Y
F
Y
-
R
--
G
-----
R
----
L
--
D
--
W
D
-
E
----
N
T
--
S
A
--
G
R
--
Y
---
V
---------
R
----------
E
---------
N
--------
C
K
P
----
L
R
R
Y
-
L
-
T
---------------
S
E
---------
A
E
-----------
E
H
H
Q
L
F
------
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
----------------
1
PsiBlast_PDB
94.97
100%
-139
- C1 -
-
6KHE
1
CLK2_HUMAN
A:
[144-485]
-----------------------------------------------------------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
--
L
C
V
Q
M
F
D
W
F
D
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
D
Y
E
L
T
Y
-
N
L
E
K
K
R
D
E
R
S
V
-----
K
S
T
A
----------------
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
------
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
---
R
K
-
T
R
K
Q
K
Y
F
Y
-
R
--
G
-----
R
----
L
--
D
--
W
D
-
E
----
N
T
--
S
A
--
G
R
--
Y
---
V
---------
R
----------
E
---------
N
--------
C
K
P
----
L
R
R
Y
-
L
-
T
---------------
S
E
---------
A
E
-----------
E
H
H
Q
L
F
------
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
E
--------------
225
HHSearch
94.76
99%
-139
- C1 -
-
6KHE
1
CLK2_HUMAN
A:
[144-485]
-----------------------------------------------------------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
--
L
C
V
Q
M
F
D
W
F
D
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
D
Y
E
L
T
Y
-
N
L
E
K
K
R
D
E
R
S
V
-----
K
S
T
A
----------------
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
------
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
---
R
K
-
T
R
K
Q
K
Y
F
Y
-
R
--
G
-----
R
----
L
--
D
--
W
D
-
E
----
N
T
--
S
A
--
G
R
--
Y
---
V
---------
R
----------
E
---------
N
--------
C
K
P
----
L
R
R
Y
-
L
-
T
---------------
S
E
---------
A
E
-----------
E
H
H
Q
L
F
------
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
E
--------------
3
PsiBlast_PDB
93.59
99%
-135
- C1 -
-
6FYI
1
CLK2_HUMAN
A:
[20-355]
---------------------------------------------------------------------------------------------------------------------------------------------------
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
--
L
C
V
Q
M
F
D
W
F
D
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
D
Y
E
L
T
Y
-
N
L
E
K
K
R
D
E
R
S
V
-----
K
S
T
A
----------------
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
------
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
---
R
K
-
T
R
K
Q
K
Y
F
Y
-
R
--
G
-----
R
----
L
--
D
--
W
D
-
E
----
N
T
--
S
A
--
G
R
--
Y
---
V
---------
R
----------
E
---------
N
--------
C
K
P
----
L
R
R
Y
-
L
-
T
---------------
S
E
---------
A
E
-----------
E
H
H
Q
L
F
------
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
----------------
8
PsiBlast_PDB
88.84
71%
-135
- C1 -
-
2WU6
7
CLK3_HUMAN
A:
[31-375]
--------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
--
L
C
V
L
M
S
D
W
F
N
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
-
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
E
F
E
T
L
Y
-
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
----------------
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
---
H
R
-
T
R
K
Q
K
Y
F
Y
-
K
--
G
-----
G
----
L
--
V
--
W
D
-
E
----
N
S
--
S
D
--
G
R
--
Y
---
V
---------
K
----------
E
---------
N
--------
C
K
P
----
L
K
S
Y
-
M
-
L
---------------
Q
D
---------
S
L
-----------
E
H
V
Q
L
F
------
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
--------------
27
Blastp_CBE
88.08
71%
-128
- C1 -
-
6FT7
8
CLK3_HUMAN
B:
[5-354]
---------------------------------------------------------------------------------------------------------------------------------------
S
K
R
S
S
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
--
L
C
V
L
M
S
D
W
F
N
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
-
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
E
F
E
T
L
Y
-
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
----------------
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
---
H
R
-
T
R
K
Q
K
Y
F
Y
-
K
--
G
-----
G
----
L
--
V
--
W
D
-
E
----
N
S
--
S
D
--
G
R
--
Y
---
V
---------
K
----------
E
---------
N
--------
C
K
P
----
L
K
S
Y
-
M
-
L
---------------
Q
D
---------
S
L
-----------
E
H
V
Q
L
F
------
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
--------------
15
PsiBlast_PDB
87.87
71%
-130
- C1 -
-
6FYR
1
CLK3_HUMAN
A:
[4-354]
--------------------------------------------------------------------------------------------------------------------------------------
S
S
K
R
S
S
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
--
L
C
V
L
M
S
D
W
F
N
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
-
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
E
F
E
T
L
Y
-
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
----------------
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
---
H
R
-
T
R
K
Q
K
Y
F
Y
-
K
--
G
-----
G
----
L
--
V
--
W
D
-
E
----
N
S
--
S
D
--
G
R
--
Y
---
V
---------
K
----------
E
---------
N
--------
C
K
P
----
L
K
S
Y
-
M
-
L
---------------
Q
D
---------
S
L
-----------
E
H
V
Q
L
F
------
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
--------------
9
PsiBlast_PDB
87.66
71%
-131
- C1 -
-
2WU7
1
CLK3_HUMAN
A:
[32-375]
---------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
--
L
C
V
L
M
S
D
W
F
N
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
-
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
E
F
E
T
L
Y
-
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
----------------
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
---
H
R
-
T
R
K
Q
K
Y
F
Y
-
K
--
G
-----
G
----
L
--
V
--
W
D
-
E
----
N
S
--
S
D
--
G
R
--
Y
---
V
---------
K
----------
E
---------
N
--------
C
K
P
----
L
K
S
Y
-
M
-
L
---------------
Q
D
---------
S
L
-----------
E
H
V
Q
L
F
------
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
--------------
230
HHSearch
87.46
72%
-132
- C1 -
-
6FT7
7
CLK3_HUMAN
B:
[14-354]
------------------------------------------------------------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
--
L
C
V
L
M
S
D
W
F
N
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
-
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
E
F
E
T
L
Y
-
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
----------------
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
---
H
R
-
T
R
K
Q
K
Y
F
Y
-
K
--
G
-----
G
----
L
--
V
--
W
D
-
E
----
N
S
--
S
D
--
G
R
--
Y
---
V
---------
K
----------
E
---------
N
--------
C
K
P
----
L
K
S
Y
-
M
-
L
---------------
Q
D
---------
S
L
-----------
E
H
V
Q
L
F
------
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
--------------
12
PsiBlast_PDB
87.23
71%
-127
- C1 -
-
6RCT
8
CLK3_HUMAN
A:
[11-354]
---------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
--
L
C
V
L
M
S
D
W
F
N
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
-
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
E
F
E
T
L
Y
-
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
----------------
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
---
H
R
-
T
R
K
Q
K
Y
F
Y
-
K
--
G
-----
G
----
L
--
V
--
W
D
-
E
----
N
S
--
S
D
--
G
R
--
Y
---
V
---------
K
----------
E
---------
N
--------
C
K
P
----
L
K
S
Y
-
M
-
L
---------------
Q
D
---------
S
L
-----------
E
H
V
Q
L
F
------
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
--------------
16
PsiBlast_PDB
87.08
70%
-130
- C1 -
-
2EU9
1
CLK3_HUMAN
A:
[1-346]
----------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
--
L
C
V
L
M
S
D
W
F
N
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
-
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
E
F
E
T
L
Y
-
N
E
H
-
S
C
E
E
K
S
V
-----
K
N
T
S
----------------
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
---
H
R
-
T
R
K
Q
K
Y
F
Y
-
K
--
G
-----
G
----
L
--
V
--
W
D
-
E
----
N
S
--
S
D
--
G
R
--
Y
---
V
---------
K
----------
E
---------
N
--------
C
K
P
----
L
K
S
Y
-
M
-
L
---------------
Q
D
---------
S
L
-----------
E
H
V
Q
L
F
------
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
--
P
E
E
R
S
---------
10
PsiBlast_PDB
87.06
71%
-132
- C1 -
-
3RAW
1
CLK3_HUMAN
A:
[31-375]
--------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
--
L
C
V
L
M
S
D
W
F
N
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
-
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
E
F
E
T
L
Y
-
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
----------------
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
---
H
R
-
T
R
K
Q
K
Y
F
Y
-
K
--
G
-----
G
----
L
--
V
--
W
D
-
E
----
N
S
--
S
D
--
G
R
--
Y
---
V
---------
K
----------
E
---------
N
--------
C
K
P
----
L
K
S
Y
-
M
-
L
---------------
Q
D
---------
S
L
-----------
E
H
V
Q
L
F
------
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
--------------
14
PsiBlast_PDB
86.96
71%
-130
- C1 -
-
6FYP
1
CLK3_HUMAN
A:
[11-354]
---------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
--
L
C
V
L
M
S
D
W
F
N
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
-
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
E
F
E
T
L
Y
-
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
----------------
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
---
H
R
-
T
R
K
Q
K
Y
F
Y
-
K
--
G
-----
G
----
L
--
V
--
W
D
-
E
----
N
S
--
S
D
--
G
R
--
Y
---
V
---------
K
----------
E
---------
N
--------
C
K
P
----
L
K
S
Y
-
M
-
L
---------------
Q
D
---------
S
L
-----------
E
H
V
Q
L
F
------
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
--------------
28
Blastp_CBE
86.85
71%
-128
- C1 -
-
3RAW
1
CLK3_HUMAN
B:
[33-375]
----------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
--
L
C
V
L
M
S
D
W
F
N
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
-
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
E
F
E
T
L
Y
-
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
----------------
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
---
H
R
-
T
R
K
Q
K
Y
F
Y
-
K
--
G
-----
G
----
L
--
V
--
W
D
-
E
----
N
S
--
S
D
--
G
R
--
Y
---
V
---------
K
----------
E
---------
N
--------
C
K
P
----
L
K
S
Y
-
M
-
L
---------------
Q
D
---------
S
L
-----------
E
H
V
Q
L
F
------
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
--------------
18
PsiBlast_PDB
86.79
67%
-140
- C1 -
-
6FYV
1
CLK4_HUMAN
A:
[5-336]
-------------------------------------------------------------------------------------------------------------------------------------------------------
I
C
Q
S
G
D
V
L
R
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
G
M
D
G
M
H
V
A
V
K
I
V
K
N
V
G
R
Y
R
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
S
T
D
P
N
S
V
F
--
R
C
V
Q
M
L
E
W
F
D
H
H
G
----
H
V
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
S
F
L
P
F
Q
I
D
H
I
R
Q
M
A
Y
Q
I
C
Q
S
I
N
F
L
H
--
H
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
K
S
D
Y
V
V
K
Y
-
N
---
K
R
D
E
R
T
L
-----
K
N
T
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
Q
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
I
P
Q
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
N
-----
Q
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
R
----------
R
---------
R
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
C
H
---------
D
E
-----------
E
H
E
K
L
F
------
D
L
V
R
R
M
L
E
Y
D
P
T
Q
R
I
T
L
D
E
A
L
Q
H
P
F
F
D
L
L
K
----------------
229
HHSearch
86.64
72%
-135
- C1 -
-
6FYR
1
CLK3_HUMAN
A:
[15-352]
-------------------------------------------------------------------------------------------------------------------------------------------------
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
--
L
C
V
L
M
S
D
W
F
N
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
-
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
E
F
E
T
L
Y
-
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
----------------
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
---
H
R
-
T
R
K
Q
K
Y
F
Y
-
K
--
G
-----
G
----
L
--
V
--
W
D
-
E
----
N
S
--
S
D
--
G
R
--
Y
---
V
---------
K
----------
E
---------
N
--------
C
K
P
----
L
K
S
Y
-
M
-
L
---------------
Q
D
---------
S
L
-----------
E
H
V
Q
L
F
------
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
----------------
26
Blastp_CBE
86.64
71%
-125
- C1 -
-
6RCT
7
CLK3_HUMAN
B:
[10-354]
--------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
--
L
C
V
L
M
S
D
W
F
N
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
-
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
E
F
E
T
L
Y
-
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
----------------
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
---
H
R
-
T
R
K
Q
K
Y
F
Y
-
K
--
G
-----
G
----
L
--
V
--
W
D
-
E
----
N
S
--
S
D
--
G
R
--
Y
---
V
---------
K
----------
E
---------
N
--------
C
K
P
----
L
K
S
Y
-
M
-
L
---------------
Q
D
---------
S
L
-----------
E
H
V
Q
L
F
------
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
--------------
44
Blastp_CBE
86.22
66%
-138
- C1 -
-
6G33
1
CLK1_HUMAN
C:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
----------
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
11
PsiBlast_PDB
86.20
71%
-127
- C1 -
-
6FT7
7
CLK3_HUMAN
A:
[5-354]
---------------------------------------------------------------------------------------------------------------------------------------
S
K
R
S
S
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
--
L
C
V
L
M
S
D
W
F
N
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
-
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
E
F
E
T
L
Y
-
N
E
H
K
S
C
E
E
K
S
V
-----
K
N
T
S
----------------
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
---
H
R
-
T
R
K
Q
K
Y
F
Y
-
K
--
G
-----
G
----
L
--
V
--
W
D
-
E
----
N
S
--
S
D
--
G
R
--
Y
---
V
---------
K
----------
E
---------
N
--------
C
K
P
----
L
K
S
Y
-
M
-
L
---------------
Q
D
---------
S
L
-----------
E
H
V
Q
L
F
------
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
--------------
48
Blastp_CBE
85.92
66%
-137
- C1 -
-
6FT9
4
CLK1_HUMAN
A:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
37
Blastp_CBE
85.89
66%
-140
- C1 -
-
6I5L
2
CLK1_HUMAN
B:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
32
Blastp_CBE
85.80
66%
-143
- C1 -
-
6Q8P
1
CLK1_HUMAN
C:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
--
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
-
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
40
Blastp_CBE
85.72
66%
-143
- C1 -
-
6I5K
5
CLK1_HUMAN
B:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
59
Blastp_CBE
85.70
66%
-141
- C1 -
-
2VAG
1
CLK1_HUMAN
A:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
---
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
45
Blastp_CBE
85.68
66%
-139
- C1 -
-
6G33
1
CLK1_HUMAN
B:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
31
Blastp_CBE
85.62
66%
-139
- C1 -
-
6RAA
2
CLK1_HUMAN
A:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
39
Blastp_CBE
85.60
66%
-140
- C1 -
-
6I5K
3
CLK1_HUMAN
C:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
58
Blastp_CBE
85.49
66%
-140
- C1 -
-
6G33
1
CLK1_HUMAN
A:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
43
Blastp_CBE
85.47
66%
-146
- C1 -
-
6I5H
7
CLK1_HUMAN
A:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
------------
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
33
Blastp_CBE
85.38
66%
-144
- C1 -
-
6Q8P
1
CLK1_HUMAN
B:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
---
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
--
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
47
Blastp_CBE
85.33
66%
-141
- C1 -
-
6FT9
2
CLK1_HUMAN
B:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
36
Blastp_CBE
85.32
66%
-140
- C1 -
-
6I5L
4
CLK1_HUMAN
C:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
42
Blastp_CBE
85.26
66%
-137
- C1 -
-
6I5I
13
CLK1_HUMAN
A:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
-----------
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
35
Blastp_CBE
85.20
66%
-139
- C1 -
-
6Q8K
2
CLK1_HUMAN
A:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
34
Blastp_CBE
85.20
66%
-139
- C1 -
-
6Q8P
1
CLK1_HUMAN
A:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
-
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
54
Blastp_CBE
85.14
66%
-137
- C1 -
-
5J1V
1
CLK1_HUMAN
B:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
41
Blastp_CBE
85.13
66%
-139
- C1 -
-
6I5K
3
CLK1_HUMAN
A:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
228
HHSearch
85.12
71%
-143
- C1 -
-
6KHF
1
CLK3_HUMAN
A:
[142-481]
----------------------------------------------------------------------------------------------------------------------------------------------------
G
H
L
V
C
R
I
G
D
W
L
Q
E
D
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
--
L
C
V
L
M
S
D
W
F
N
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
-
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
E
F
--------------
S
V
-----
K
N
T
S
----------------
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
---
H
R
-
T
R
K
Q
K
Y
F
Y
-
K
--
G
-----
G
----
L
--
V
--
W
D
-
E
----
N
S
--
S
D
--
G
R
--
Y
---
V
---------
K
----------
E
---------
N
--------
C
K
P
----
L
K
S
Y
-
M
-
L
---------------
Q
D
---------
S
L
-----------
E
H
V
Q
L
F
------
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
--
R
S
---------
38
Blastp_CBE
85.11
66%
-139
- C1 -
-
6I5L
3
CLK1_HUMAN
A:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
19
PsiBlast_PDB
85.10
66%
-136
- C1 -
-
1Z57
1
CLK1_HUMAN
A:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
----
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
46
Blastp_CBE
85.05
66%
-138
- C1 -
-
6FT9
2
CLK1_HUMAN
C:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
49
Blastp_CBE
84.97
66%
-139
- C1 -
-
6FT8
7
CLK1_HUMAN
A:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
20
PsiBlast_PDB
84.96
66%
-135
- C1 -
-
5J1V
2
CLK1_HUMAN
A:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
51
Blastp_CBE
84.91
66%
-135
- C1 -
-
5J1W
3
CLK1_HUMAN
B:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
233
HHSearch
84.71
66%
-136
- C1 -
-
1Z57
1
CLK1_HUMAN
A:
[5-336]
-------------------------------------------------------------------------------------------------------------------------------------------------------
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
----
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
52
Blastp_CBE
84.68
66%
-133
- C1 -
-
5J1W
6
CLK1_HUMAN
A:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
231
HHSearch
84.56
66%
-139
- C1 -
-
6I5L
4
CLK1_HUMAN
C:
[6-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
232
HHSearch
84.35
66%
-138
- C1 -
-
6FT8
7
CLK1_HUMAN
A:
[6-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
57
Blastp_CBE
84.29
66%
-135
- C1 -
-
6FYO
1
CLK1_HUMAN
A:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
---
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
R
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
226
HHSearch
84.09
67%
-136
- C1 -
-
6KHD
1
CLK1_HUMAN
B:
[149-481]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
--
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
227
HHSearch
83.82
67%
-144
- C1 -
-
6KHD
1
CLK1_HUMAN
A:
[149-481]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
----------
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
--
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
56
Blastp_CBE
83.53
66%
-135
- C1 -
-
5X8I
1
CLK1_HUMAN
A:
[8-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
55
Blastp_CBE
83.24
66%
-136
- C1 -
-
5X8I
1
CLK1_HUMAN
B:
[9-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
7
PsiBlast_PDB
82.15
59%
-143
- C1 -
-
6KHF
1
CLK3_HUMAN
A:
[142-481]
----------------------------------------------------------------------------------------------------------------------------------------------------
G
H
L
V
C
R
I
G
D
W
L
Q
E
D
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
--
L
C
V
L
M
S
D
W
F
N
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
--
E
N
-
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
E
F
--------------
S
V
-----
K
N
T
S
----------------
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
---
H
R
-
T
R
K
Q
K
Y
F
Y
-
K
--
G
-----
G
----
L
--
V
--
W
D
-
E
----
N
S
--
S
D
--
G
R
--
Y
---
V
---------
K
----------
E
---------
N
--------
C
K
P
----
L
K
S
Y
-
M
-
L
---------------
Q
D
---------
S
L
-----------
E
H
V
Q
L
F
------
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
--
T
P
E
E
R
S
---------
30
Blastp_CBE
81.83
56%
-136
- C1 -
-
6KHD
1
CLK1_HUMAN
B:
[149-481]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
--
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
17
PsiBlast_PDB
81.62
56%
-144
- C1 -
-
6KHD
1
CLK1_HUMAN
A:
[149-481]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
----------
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
--
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
29
Blastp_CBE
81.10
56%
-140
- C1 -
-
6KHD
1
CLK1_HUMAN
C:
[150-479]
-------------------------------------------------------------------------------------------------------------------------------------------------------
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
-----
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
F
H
-
H
--
D
-----
R
----
L
--
D
--
W
D
-
E
----
H
S
--
S
A
--
G
R
--
Y
---
V
---------
S
----------
R
---------
A
--------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
------------------
53
Blastp_CBE
80.33
66%
-147
- C1 -
-
5J1V
2
CLK1_HUMAN
C:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
---
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
Y
---------------------------------------------------------------------------------------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
50
Blastp_CBE
79.72
66%
-141
- C1 -
-
5J1W
5
CLK1_HUMAN
C:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
--
S
N
-
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
A
Y
-
N
P
K
I
K
R
D
E
R
T
L
-----
I
N
P
D
----------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
---
Q
K
-
T
R
K
R
K
----------------------------------------------------------------------------------------
C
K
P
----
L
K
E
F
-
M
-
L
---------------
S
Q
---------
D
V
-----------
E
H
E
R
L
F
------
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
235
HHSearch
65.16
33%
-109
- C1 -
-
5LXC
5
DYRK2_HUMAN
B:
[71-394]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
-
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
--
N
V
I
H
M
L
E
N
F
T
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
-
R
I
I
--
H
C
D
L
K
P
E
N
I
L
L
-
K
Q
Q
G
-----------------------
R
S
G
----------------
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
------
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
---
D
A
-
S
K
R
A
K
N
F
V
-
S
--
S
KG---
Y
----
P
--
R
--
Y
C
-
T
----
V
T
--
T
L
SD
G
S
--
V
---
V
---------
L
NGGRSRRGKL
R
---------
G
--------
P
P
E
----
S
R
E
W
G
N
-
A
---------------
L
K
---------
G
C
-----------
D
D
P
L
F
L
------
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
-----------------
234
HHSearch
64.50
33%
-114
- C1 -
-
6HDP
1
DYRK2_HUMAN
A:
[93-419]
------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
--
N
V
I
H
M
L
E
N
F
T
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
-
R
I
I
--
H
C
D
L
K
P
E
N
I
L
L
-
K
Q
Q
G
-----------------------
R
S
G
----------------
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
------
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
---
D
A
-
S
K
R
A
K
N
F
V
-
S
--
S
KG---
Y
----
P
--
R
--
Y
C
-
T
----
V
T
--
T
L
SD
G
S
V-
V
LNG
G
---------
R
SRRGKL----
R
---------
G
--------
P
P
E
----
S
R
E
W
G
N
-
A
---------------
L
K
---------
G
C
-----------
D
D
P
L
F
L
------
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
L
P
K
P
-------------
241
HHSearch
63.98
31%
-112
- C1 -
-
6K0J
1
?
A:
[4-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
N
N
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
--
N
V
I
H
M
L
E
N
F
T
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
-
R
I
I
--
H
C
D
A
K
P
E
N
I
L
L
-
K
Q
Q
G
-----------------------
R
S
G
----------------
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
------
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
---
D
A
-
S
K
R
A
K
N
F
V
-
S
--
S
KGYPR
Y
----
C
--
T
--
V
T
-
T
----
L
S
--
D
G
--
S
V
--
V
---
L
---------
N
----------
G
GRSRRGKLR
G
--------
P
P
E
----
S
R
E
W
G
N
-
A
---------------
L
K
---------
G
C
-----------
D
D
P
L
F
L
------
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
A
------------------
236
HHSearch
63.90
34%
-118
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[93-413]
------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
-
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
--
N
V
I
H
M
L
E
N
F
T
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
-
R
I
I
--
H
C
D
L
K
P
E
N
I
L
L
-
K
Q
Q
G
-----------------------
R
S
G
----------------
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
------
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
---
D
A
-
S
K
R
A
K
N
F
V
-
S
SK
G
-----
Y
----
P
--
R
--
Y
C
-
T
----
V
T
TL
S
D
------
V
---
V
LNGG-----
R
SRRGKL----
R
---------
G
--------
P
P
E
----
S
R
E
W
G
N
-
A
---------------
L
K
---------
G
C
-----------
D
D
P
L
F
L
------
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-------------------
239
HHSearch
63.02
31%
-104
- C1 -
-
5Y86
8
DYRK3_HUMAN
A:
[195-526]
----------------------------------------------------------------------------------------------------------------------------------------------------
G
A
Y
I
H
V
P
R
D
H
L
A
Y
R
Y
E
V
L
K
I
I
G
K
G
S
F
G
Q
V
A
R
V
Y
D
H
K
-
L
R
Q
Y
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
K
K
Q
D
K
T
G
S
M
--
N
V
I
H
M
L
E
S
F
T
F
R
N
----
H
V
C
M
A
F
E
L
L
S
I
D
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
V
Q
L
V
R
K
F
A
Q
S
I
L
Q
S
L
D
A
L
H
--
K
N
-
K
I
I
--
H
C
D
L
K
P
E
N
I
L
L
-
K
H
H
G
-----------------------
R
S
S
----------------
T
K
V
I
D
F
G
S
S
C
F
E
Y
Q
K
L
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
I
I
L
G
S
R
Y
S
T
P
I
D
I
W
S
F
G
C
I
L
A
E
L
L
T
G
Q
P
L
F
P
G
E
D
E
G
D
------
Q
L
A
C
M
M
E
L
L
G
M
P
P
P
K
L
L
---
E
Q
-
S
K
R
A
K
Y
F
I
-
N
--
S
-----
K
----
G
IP
R
--
Y
C
-
S
VTTQ
A
D
--
G
R
--
V
V
--
L
---
V
---------
G
----------
G
---------
R
SRRGKKRG
P
P
G
----
S
K
D
W
-
G
T
A
---------------
L
K
---------
G
C
-----------
D
D
Y
L
F
I
------
E
F
L
K
R
C
L
H
W
D
P
S
A
R
L
T
P
A
Q
A
L
R
H
P
W
I
S
K
S
V
----------------
60
Blastp_CBE
61.96
37%
-60
- C1 -
-
3LLT
1
?
A:
[20-359]
-------------------------------------------------------------------------------------------------------------------------------------------------
D
E
I
V
H
F
S
W
K
K
G
M
L
L
N
N
A
F
L
V
I
R
K
M
G
D
G
T
F
G
R
V
L
L
C
-
Q
H
I
D
N
K
K
Y
Y
A
V
K
V
V
R
N
I
K
K
Y
T
R
S
A
K
I
E
A
D
I
L
K
K
I
-
Q
N
D
D
I
N
N
N
--
N
I
V
K
Y
H
G
K
F
M
Y
Y
D
----
H
M
C
L
I
F
E
P
L
G
P
S
L
Y
E
I
I
T
R
-
N
N
Y
N
G
F
H
I
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
R
--
K
M
-
S
L
T
--
H
T
D
L
K
P
E
N
I
L
L
-
D
D
P
Y
F
E
K
S
L
I
T
V
R
R
V
T
D
G
K
K
I
QIYRT
K
S
T
G
----------------
I
K
L
I
D
F
G
C
A
T
F
K
S
D
Y
H
G
S
I
I
N
T
R
Q
Y
R
A
P
E
V
I
L
N
L
G
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
G
S
L
L
F
R
T
H
E
H
M
E
------
H
L
A
M
M
E
S
I
I
Q
P
I
P
K
N
M
L
YEA
T
K
-
T
N
G
S
K
Y
V
N
-
K
--
D
EL---
K
----
L
--
A
--
W
P
-
E
----
N
A
--
S
S
--
I
N
--
S
---
I
---------
K
HV--------
K
---------
K
--------
C
L
P
----
L
Y
K
I
-
I
-
K
-----------------------------------------
H
E
L
F
C-----
D
F
L
Y
S
I
L
Q
I
D
P
T
L
R
P
S
P
A
E
L
L
K
H
K
F
L
--------------------
244
HHSearch
59.93
33%
-83
* C1 *
-
6S1H
4
DYR1A_HUMAN
A:
[22-355]
-----------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
R
-
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
--
Y
I
V
H
L
K
R
H
F
M
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
TP
E
L
-
S
I
I
--
H
C
D
L
K
P
E
N
I
L
L
-
C
N
P
K
-----------------------
R
S
A
----------------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
------
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
---
D
Q
-
A
P
K
A
R
K
F
F
-
E
--
K
LP---
D
----
G
--
T
--
W
N
-
L
----
K
K
---------------------------------------------
Y
--------
K
P
P
GTRK
L
H
N
I
-
L
-
G
VETGGPGGRRAGESG
H
T
---------
V
A
-----------
D
Y
L
K
F
K
------
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
--------------------
61
Blastp_CBE
59.13
32%
-78
- C1 -
-
5LXD
6
DYRK2_HUMAN
B:
[60-394]
------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
--
N
V
I
H
M
L
E
N
F
T
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
-
R
I
I
--
H
C
D
L
K
P
E
N
I
L
L
---------------
K
Q
Q
G
R
S
---------
G
----------------
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
I
Q
S
-
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
------
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
---
D
A
-
S
K
R
A
K
N
F
V
-
S
--
S
KGYP-
R
----
Y
--
C
--
T
V
-
T
----
T
L
--
S
D
--
G
S
--
V
---
V
---------
L
----------
N
---------
G
--------
G
R
S
----
R
R
G
K
-
L
-
R
---------------
G
P
---------
P
E
SREWGNALKGC
D
D
P
L
F
L
------
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
L
----------------
64
Blastp_CBE
56.77
32%
-75
- C1 -
-
5LXC
9
DYRK2_HUMAN
A:
[60-392]
------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
--
N
V
I
H
M
L
E
N
F
T
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
-
R
I
I
--
H
C
D
L
K
P
E
N
I
L
L
---------------
K
Q
Q
G
R
S
---------
G
----------------
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
I
Q
S
-
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
------
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
---
D
A
-
S
K
R
A
K
N
F
V
-
S
--
S
KGYP-
R
----
Y
--
C
--
T
V
-
T
----
T
L
--
S
D
--
G
S
--
V
---
V
---------
L
----------
N
---------
G
--------
G
R
S
----
R
R
G
K
-
L
-
R
---------------
G
P
---------
P
E
SREWGNALKGC
D
D
P
L
F
L
------
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
------------------
70
Blastp_CBE
55.44
32%
-79
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[81-413]
------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
--
N
V
I
H
M
L
E
N
F
T
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
-
R
I
I
--
H
C
D
L
K
P
E
N
I
L
L
---------------
K
Q
Q
G
R
S
---------
G
----------------
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
I
Q
S
-
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
------
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
---
D
A
-
S
K
R
A
K
N
F
V
S
K
--
G
YP---
R
----
Y
--
C
--
T
V
-
T
----
T
L
--
S
D
--
G
S
----------------
L
----------
N
---------
G
--------
G
R
S
----
R
R
G
K
-
L
-
R
---------------
G
P
---------
P
E
SREWGNALKGC
D
D
P
L
F
L
------
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
------------------
173
Blastp_CBE
54.85
32%
-75
- C1 -
-
6S11
1
DYR1A_HUMAN
A:
[28-356]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
--
Y
I
V
H
L
K
R
H
F
M
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
--
T
P
-
E
L
S
II
H
C
D
L
K
P
E
N
I
L
L
-
C
N
P
-----------------------
K
R
S
A
----------------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
I
Q
S
-
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
------
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
---
D
Q
-
A
P
K
A
R
K
F
F
-
E
--
K
-----
L
----
P
--
D
GT
W
N
L
K
----
K
T
--
K
-----RE
Y
---
K
---------
P
----------
P
---------
G
--------
T
R
K
----
L
H
N
I
-
L
-
G
---------------
V
E
TGGPGGRRA
G
E
-----------
S
G
H
T
V
A
DYLKFK
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
------------------
68
Blastp_CBE
54.83
32%
-81
- C1 -
-
6HDR
2
DYRK2_HUMAN
A:
[81-413]
------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
--
N
V
I
H
M
L
E
N
F
T
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
-
R
I
I
--
H
C
D
L
K
P
E
N
I
L
L
---------------
K
Q
Q
G
R
S
---------
G
----------------
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
I
Q
S
-
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
------
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
---
D
A
-
S
K
R
A
K
N
F
V
S
K
--
G
YP---
R
----
Y
--
C
--
T
V
-
T
----
T
L
--
S
D
--
G
S
----------------
L
----------
N
---------
G
--------
G
R
S
----
R
R
G
K
-
L
-
R
---------------
G
P
---------
P
E
SREWGNALKGC
D
D
P
L
F
L
------
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
-----------------
65
Blastp_CBE
54.83
32%
-74
- C1 -
-
6HDP
1
DYRK2_HUMAN
A:
[81-419]
------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
--
N
V
I
H
M
L
E
N
F
T
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
-
R
I
I
--
H
C
D
L
K
P
E
N
I
L
L
---------------
K
Q
Q
G
R
S
---------
G
----------------
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
I
Q
S
-
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
------
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
---
D
A
-
S
K
R
A
K
N
F
V
S
K
--
G
YP---
R
----
Y
--
C
--
T
V
-
T
----
T
L
--
S
D
--
G
S
--
V
---
V
---------
L
----------
N
---------
G
--------
G
R
S
----
R
R
G
K
-
L
-
R
---------------
G
P
---------
P
E
SREWGNALKGC
D
D
P
L
F
L
------
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
L
P
K
P
P
T
-----------
170
Blastp_CBE
54.62
32%
-75
- C1 -
-
6S17
8
DYR1A_HUMAN
A:
[28-357]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
--
Y
I
V
H
L
K
R
H
F
M
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
--
T
P
-
E
L
S
II
H
C
D
L
K
P
E
N
I
L
L
-
C
N
P
-----------------------
K
R
S
A
----------------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
I
Q
S
-
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
------
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
---
D
Q
-
A
P
K
A
R
K
F
F
-
E
--
K
-----
L
----
P
--
D
GT
W
N
L
K
----
K
T
----------
Y
---
K
---------
P
----------
P
---------
G
--------
T
R
K
----
L
H
N
I
-
L
-
G
---------------
V
E
TGGPGGRRA
G
E
-----------
S
G
H
T
V
A
DYLKFK
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
------------------
178
Blastp_CBE
54.20
32%
-74
- C1 -
-
4YLL
10
DYR1A_HUMAN
A:
[28-357]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
-
K
Y
--
Y
I
V
H
L
K
R
H
F
M
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
--
T
P
-
E
L
S
II
H
C
D
L
K
P
E
N
I
L
L
-
C
N
P
-----------------------
K
R
S
A
----------------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
I
Q
S
-
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
------
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
---
D
Q
-
A
P
K
A
R
K
F
F
-
E
--
K
-----
L
----
P
--
D
GT
W
N
L
K
----
K
T
----------
Y
---
K
---------
P
----------
P
---------
G
--------
T
R
K
----
L
H
N
I
-
L
-
G
---------------
V
E
TGGPGGRRA
G
E
-----------
S
G
H
T
V
A
DYLKFK
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
------------------
69
Blastp_CBE
54.13
32%
-78
- C1 -
-
3KVW
1
DYRK2_HUMAN
A:
[81-413]
------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
--
N
V
I
H
M
L
E
N
F
T
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
-
R
I
I
--
H
C
D
L
K
P
E
N
I
L
L
---------------
K
Q
Q
G
R
S
---------
G
----------------
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
I
Q
S
-
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
------
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
---
D
A
-
S
K
R
A
K
N
F
V
S
K
--
G
YP---
R
----
Y
--
C
--
T
V
-
T
----
T
L
--
S
D
--
G
S
----------------
L
----------
N
---------
G
--------
G
R
S
----
R
R
G
K
-
L
-
R
---------------
G
P
---------
P
E
SREWGNALKGC
D
D
P
L
F
L
------
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
-----------------
72
Blastp_CBE
54.09
32%
-82
- C1 -
-
6K0J
1
?
A:
[5-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
N
N
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
--
N
V
I
H
M
L
E
N
F
T
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
-
R
I
I
--
H
C
D
A
K
P
E
N
I
L
L
---------------
K
Q
Q
G
R
S
---------
G
----------------
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
I
-
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
------
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
---
D
A
-
S
K
R
A
K
N
F
V
S
K
--
G
YP---
R
----
Y
--
C
--
T
V
-
T
----
T
L
--
S
D
--
G
S
--
V
---
V
---------
L
----------
N
---------
G
--------
G
R
S
----
R
R
G
K
-
L
-
R
---------------
G
P
---------
P
E
SREWGNALKGC
D
D
P
L
F
L
------
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
--------------------
206
Blastp_CBE
53.87
32%
-71
- C1 -
-
4AZE
1
DYR1A_HUMAN
C:
[49-378]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
--
Y
I
V
H
L
K
R
H
F
M
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
--
T
P
-
E
L
S
II
H
C
D
L
K
P
E
N
I
L
L
-
C
N
P
-----------
K
R
S
------------
A
----------------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
I
Q
S
-
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
------
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
---
D
Q
-
A
P
K
A
R
K
F
F
-
E
--
K
-----
L
----
P
--
D
GT
W
N
L
K
----
K
T
--
K
D
--
G
K
RE
Y
---
K
---------
P
----------
P
---------
G
--------
T
R
K
----
L
H
N
I
-
L
-
G
---------------
V
E
TGGPGGRRA
G
E
-----------
S
G
H
T
V
A
DYLKFK
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
------------------
199
Blastp_CBE
53.47
32%
-73
- C1 -
-
2WO6
1
DYR1A_HUMAN
B:
[49-377]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
--
Y
I
V
H
L
K
R
H
F
M
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
--
T
P
-
E
L
S
II
H
C
D
L
K
P
E
N
I
L
L
-
C
N
P
-----------------------
K
R
S
A
----------------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
I
Q
S
-
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
------
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
---
D
Q
-
A
P
K
A
R
K
F
F
-
E
--
K
-----
L
----
P
--
D
GT
W
N
L
K
----
K
---------RE
Y
---
K
---------
P
----------
P
---------
G
--------
T
R
K
----
L
H
N
I
-
L
-
G
---------------
V
E
TGGPGGRRA
G
E
-----------
S
G
H
T
V
A
DYLKFK
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
------------------
171
Blastp_CBE
53.31
32%
-72
- C1 -
-
6S14
1
DYR1A_HUMAN
A:
[28-357]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
--
Y
I
V
H
L
K
R
H
F
M
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
--
T
P
-
E
L
S
II
H
C
D
L
K
P
E
N
I
L
L
-
C
N
P
-----------------------
K
R
S
A
----------------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
I
Q
S
-
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
------
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
---
D
Q
-
A
P
K
A
R
K
F
F
-
E
--
K
-----
L
----
P
--
D
GT
W
N
L
K
----
K
T
--------------
K
---------
P
----------
P
---------
G
--------
T
R
K
----
L
H
N
I
-
L
-
G
---------------
V
E
TGGPGGRRA
G
E
-----------
S
G
H
T
V
A
DYLKFK
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
------------------
66
Blastp_CBE
53.15
32%
-76
- C1 -
-
5ZTN
1
DYRK2_HUMAN
B:
[81-413]
------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
--
N
V
I
H
M
L
E
N
F
T
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
-
R
I
I
--
H
C
D
L
K
P
E
N
I
L
L
---------------
K
Q
Q
G
R
S
---------
G
----------------
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
I
Q
S
-
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
------
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
---
D
A
-
S
K
R
A
K
N
F
V
S
K
--
G
YP---
R
----
Y
--
C
--
T
V
-
T
----
T
L
-----------------------------------
N
---------
G
--------
G
R
S
----
R
R
G
K
-
L
-
R
---------------
G
P
---------
P
E
SREWGNALKGC
D
D
P
L
F
L
------
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
-----------------
194
Blastp_CBE
53.04
32%
-72
- C1 -
-
6A1F
2
DYR1A_HUMAN
A:
[29-358]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
--
Y
I
V
H
L
K
R
H
F
M
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
--
T
P
-
E
L
S
II
H
C
D
L
K
P
E
N
I
L
L
-
C
N
P
-----------------------
K
R
S
A
----------------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
I
Q
S
-
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
------
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
---
D
Q
-
A
P
K
A
R
K
F
F
-
E
--
K
-----
L
----
P
--
D
GT
W
N
L
K
----
K
T
--
K
D
------
Y
---
K
---------
P
----------
P
---------
G
--------
T
R
K
----
L
H
N
I
-
L
-
G
---------------
V
E
TGGPGGRRA
G
E
-----------
S
G
H
T
V
A
DYLKFK
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
------------------
163
Blastp_CBE
52.86
32%
-71
- C1 -
-
6S1J
8
DYR1A_HUMAN
A:
[28-356]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
--
Y
I
V
H
L
K
R
H
F
M
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
--
T
P
-
E
L
S
II
H
C
D
L
K
P
E
N
I
L
L
-
C
N
P
-----------------------
K
R
S
A
----------------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
I
Q
S
-
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
------
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
---
D
Q
-
A
P
K
A
R
K
F
F
-
E
--
K
-----
L
----
P
--
D
GT
W
N
L
K
----
K
T
--------------
K
---------
P
----------
P
---------
G
--------
T
R
K
----
L
H
N
I
-
L
-
G
---------------
V
E
TGGPGGRRA
G
E
-----------
S
G
H
T
V
A
DYLKFK
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
------------------
208
Blastp_CBE
52.74
32%
-70
- C1 -
-
4AZE
1
DYR1A_HUMAN
A:
[49-378]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
--
Y
I
V
H
L
K
R
H
F
M
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
--
T
P
-
E
L
S
II
H
C
D
L
K
P
E
N
I
L
L
-
C
N
P
-----------
K
R
S
------------
A
----------------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
I
Q
S
-
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
------
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
---
D
Q
-
A
P
K
A
R
K
F
F
-
E
--
K
-----
L
----
P
--
D
GT
W
N
L
K
----
K
T
--
K
D
--
G
K
RE
Y
---
K
---------
P
----------
P
---------
G
--------
T
R
K
----
L
H
N
I
-
L
-
G
---------------
V
E
TGGPGGRRA
G
E
-----------
S
G
H
T
V
A
DYLKFK
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
------------------
67
Blastp_CBE
52.56
32%
-77
- C1 -
-
5ZTN
1
DYRK2_HUMAN
A:
[81-413]
------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
--
N
V
I
H
M
L
E
N
F
T
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
-
R
I
I
--
H
C
D
L
K
P
E
N
I
L
L
---------------
K
Q
Q
G
R
S
---------
G
----------------
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
I
Q
S
-
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
------
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
---
D
A
-
S
K
R
A
K
N
F
V
S
K
--
G
YP---
R
----
Y
--
C
--
T
V
-
T
----
T
L
-----------------------------------
N
---------
G
--------
G
R
S
----
R
R
G
K
-
L
-
R
---------------
G
P
---------
P
E
SREWGNALKGC
D
D
P
L
F
L
------
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
-----------------
88
Blastp_CBE
52.31
31%
-31
- C1 -
-
5MXX
14
SRPK1_HUMAN
A:
[27-397]
----------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
H
L
V
K
I
G
D
L
F
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
-
I
Q
G
K
K
F
V
A
M
K
V
V
K
S
A
E
H
Y
T
E
T
A
L
D
E
I
R
L
L
K
S
V
R
N
S
D
P
N
D
P
N
RE
M
V
V
Q
L
L
D
D
F
K
I
S
G
VNGT
H
I
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
-
S
N
Y
Q
G
L
P
L
P
C
V
K
K
I
I
Q
Q
V
L
Q
G
L
D
Y
L
H
--
T
K
C
R
I
T
--
H
T
D
I
K
P
E
N
I
L
L
S
V
N
E
Q
Y
I
R
R
L
-
A
A
E
A
T
E
--------------NFLVNPLEPKNAEKLK
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
S
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
G
E
E
YTRDED
H
I
A
L
I
I
E
L
L
G
K
V
P
R
K
L
I
---
V
A
-
G
K
Y
S
K
E
F
F
-
T
--
K
-----
K
----
G
--
D
--
L
K
-
H
----
I
T
--
K
L
--
K
P
--
W
---
G
---------
L
----------
F
---------
E
--------
V
L
-----
V
E
K
Y
-
E
-
W
---------------
S
Q
----------
E
-----------
E
A
A
G
F
T
------
D
F
L
L
P
M
L
E
L
I
P
E
K
R
A
T
A
A
E
C
L
R
H
P
W
L
--------------------
73
Blastp_CBE
51.75
32%
-58
- C1 -
-
5Y86
8
DYRK3_HUMAN
A:
[191-529]
------------------------------------------------------------------------------------------------------------------------------------------------
D
D
A
D
G
A
Y
I
H
V
P
R
D
H
L
A
Y
R
Y
E
V
L
K
I
I
G
K
G
S
F
G
Q
V
A
R
V
Y
D
H
K
L
R
-
Q
Y
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
K
K
Q
D
K
T
G
S
M
--
N
V
I
H
M
L
E
S
F
T
F
R
N
----
H
V
C
M
A
F
E
L
L
S
I
D
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
V
Q
L
V
R
K
F
A
Q
S
I
L
Q
S
L
D
A
L
H
--
K
N
-
K
I
I
--
H
C
D
L
K
P
E
N
I
L
L
---------------
K
H
H
G
R
S
T
-----
K
---------------------
V
I
D
F
G
S
S
C
F
E
Y
Q
K
L
Y
T
I
Q
S
-
R
F
Y
R
A
P
E
I
I
L
G
S
R
Y
S
T
P
I
D
I
W
S
F
G
C
I
L
A
E
L
L
T
G
Q
P
L
F
P
G
E
D
E
G
D
------
Q
L
A
C
M
M
E
L
L
G
M
P
P
P
K
L
L
---
E
Q
-
S
K
R
A
K
Y
F
I
-
N
--
K
-----
G
----
I
--
P
RY
C
S
-
V
----
T
T
--
Q
A
D-
G
R
--
V
---
V
LVGGRSRRG
K
----------
K
---------
R
--------
G
P
P
----
G
S
K
D
-
W
-
G
---------------
T
A
---------
L
K
GC---------
D
D
Y
L
F
I
------
E
F
L
K
R
C
L
H
W
D
P
S
A
R
L
P
-
A
Q
A
L
R
H
P
W
I
S
K
S
V
P
R
P
-------------
169
Blastp_CBE
51.67
32%
-70
- C1 -
-
6S1B
2
DYR1A_HUMAN
A:
[28-357]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
--
Y
I
V
H
L
K
R
H
F
M
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
--
T
P
-
E
L
S
II
H
C
D
L
K
P
E
N
I
L
L
-
C
N
P
-----------------------
K
R
S
A
----------------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
I
Q
S
-
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
------
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
---
D
Q
-
A
P
K
A
R
K
F
F
-
E
--
K
-----
L
--------GT
W
N
L
K
----
K
T
--------------
K
---------
P
----------
P
---------
G
--------
T
R
K
----
L
H
N
I
-
L
-
G
---------------
V
E
TGGPGGRRA
G
E
-----------
S
G
H
T
V
A
DYLKFK
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
------------------
193
Blastp_CBE
51.28
32%
-69
- C1 -
-
6A1G
1
DYR1A_HUMAN
A:
[29-357]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
--
Y
I
V
H
L
K
R
H
F
M
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
--
T
P
-
E
L
S
II
H
C
D
L
K
P
E
N
I
L
L
-
C
N
-------------------------
R
S
A
----------------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
I
Q
S
-
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
------
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
---
D
Q
-
A
P
K
A
R
K
F
F
-
E
--
K
-----
L
----
P
--
D
GT
W
N
L
K
----
K
-----------
Y
---
K
---------
P
----------
P
---------
G
--------
T
R
K
----
L
H
N
I
-
L
-
G
---------------
V
E
TGGPGGRRA
G
E
-----------
S
G
H
T
V
A
DYLKFK
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
------------------
192
Blastp_CBE
51.04
32%
-67
- C1 -
-
6A1G
1
DYR1A_HUMAN
B:
[29-357]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
--
Y
I
V
H
L
K
R
H
F
M
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
--
T
P
-
E
L
S
II
H
C
D
L
K
P
E
N
I
L
L
-
C
N
P
-----------------------
K
R
S
A
----------------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
I
Q
S
-
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
------
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
---
D
Q
-
A
P
K
A
R
K
F
F
-
E
--
K
-----
L
----
P
--
D
GT
W
N
L
K
----
K
---------------
K
---------
P
----------
P
---------
G
--------
T
R
K
----
L
H
N
I
-
L
-
G
---------------
V
E
TGGPGGRRA
G
E
-----------
S
G
H
T
V
A
DYLKFK
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
------------------
172
Blastp_CBE
50.66
32%
-76
- C1 -
-
6S11
1
DYR1A_HUMAN
B:
[28-356]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
--
Y
I
V
H
L
K
R
H
F
M
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
--
T
P
-
E
L
S
II
H
C
D
L
K
P
E
N
I
L
L
-
C
N
P
-----------------------
K
R
S
A
----------------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
--
I
Q
S
-
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
------
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
---
D
Q
-
A
P
K
A
R
K
F
F
-
E
--
K
-----
L
----
P
--
D
GT
W
N
L
K
----------------
Y
---
K
---------
P
----------
P
---------
G
--------
T
R
K
----
L
H
N
I
-
L
-
G
---------------
V
-TGGPGGR---
E
-----------
S
G
H
T
V
A
DYLKFK
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-------------------
78
Blastp_CBE
50.26
31%
-44
- C1 -
-
4IIR
1
PRP4B_HUMAN
A:
[15-348]
-------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
--
S
N
V
V
R
A
R
D
N
A
R
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
--
H
C
L
R
L
F
R
H
F
Y
H
K
Q
----
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
--
R
C
-
N
I
L
--
H
A
D
I
K
P
D
N
I
L
V
-
N
E
S
------------------------
K
T
I
----------------
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
------
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
---
R
K
G
V
F
K
D
Q
H
F
D
-
Q
--
N
-----
L
NFMY
I
--
E
---------------
R
--
E
K
--
V
T--
V
---------
M
----------
S
---------
T
--------
I
N
P
----
T
K
D
L
-
L
-
A
DLIGPE---------
D
Q
---------
R
K
-----------
K
V
H
Q
L
K
------
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
--------------------
77
Blastp_CBE
47.82
31%
-39
- C1 -
-
4IIR
1
B:
[15-348]
-------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
---
S
N
V
V
R
A
R
D
N
A
R
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
--
H
C
L
R
L
F
R
H
F
Y
H
K
Q
----
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
K
--
R
C
-
N
I
L
--
H
A
D
I
K
P
D
N
I
L
V
-
N
E
S
------------------------
K
T
I
----------------
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
------
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
---
R
K
G
V
F
K
D
Q
H
F
D
-
Q
--
N
-----
L
NFMY
I
--
E
--
V
D
-
K
---------
R
--
E
K
--
V
T--
V
---------
M
----------
S
---------
T
--------
I
N
P
----
T
K
D
L
-
L
-
A
DLIGRLPE-------
D
Q
---------
R
K
-----------
K
V
H
Q
L
K
------
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
--------------------
62
Blastp_CBE
40.10
32%
-78
- C1 -
-
5LXD
6
DYRK2_HUMAN
A:
[60-394]
------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
--
N
V
I
H
M
L
E
N
F
T
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
-
R
I
I
--
H
C
D
L
K
P
E
N
I
L
L
---------------
K
Q
Q
G
R
S
---------
G
----------------
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
I
Q
S
-
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
------
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
---
D
A
-
S
K
R
A
K
N
F
V
-
S
--
S
KGYP-
R
----
Y
--
C
--
T
V
-
T
----
T
L
--
S
D
--
G
S
--
V
---
V
---------
L
----------
N
---------
G
--------
G
R
S
----
R
R
G
K
-
L
-
R
---------------
G
P
---------
P
E
SREWGNALKGC
D
D
P
L
F
L
------
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
L
----------------
63
Blastp_CBE
39.71
32%
-74
- C1 -
-
5LXC
5
DYRK2_HUMAN
B:
[60-394]
------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
-
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
--
N
V
I
H
M
L
E
N
F
T
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
--
K
N
-
R
I
I
--
H
C
D
L
K
P
E
N
I
L
L
---------------
K
Q
Q
G
R
S
---------
G
----------------
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
I
Q
S
-
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
------
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
---
D
A
-
S
K
R
A
K
N
F
V
-
S
--
S
KGYP-
R
----
Y
--
C
--
T
V
-
T
----
T
L
--
S
D
--
G
S
--
V
---
V
---------
L
----------
N
---------
G
--------
G
R
S
----
R
R
G
K
-
L
-
R
---------------
G
P
---------
P
E
SREWGNALKGC
D
D
P
L
F
L
------
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
L
----------------
200
Blastp_CBE
37.29
32%
-69
- C1 -
-
2WO6
1
DYR1A_HUMAN
A:
[49-378]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
--
Y
I
V
H
L
K
R
H
F
M
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
--
T
P
-
E
L
S
II
H
C
D
L
K
P
E
N
I
L
L
-
C
N
P
-----------------------
K
R
S
A
----------------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
I
Q
S
-
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
------
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
---
D
Q
-
A
P
K
A
R
K
F
F
-
E
--
K
-----
L
----
P
--
D
GT
W
N
L
K
----
K
T
--
K
-----E-
Y
---
K
---------
P
----------
P
---------
G
--------
T
R
K
----
L
H
N
I
-
L
-
G
---------------
V
E
TGGPGGRRA
G
E
-----------
S
G
H
T
V
A
DYLKFK
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
------------------
207
Blastp_CBE
37.27
32%
-71
- C1 -
-
4AZE
1
DYR1A_HUMAN
B:
[49-378]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
--
Y
I
V
H
L
K
R
H
F
M
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
--
T
P
-
E
L
S
II
H
C
D
L
K
P
E
N
I
L
L
-
C
N
P
-----------
K
R
S
------------
A
----------------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
I
Q
S
-
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
------
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
---
D
Q
-
A
P
K
A
R
K
F
F
-
E
--
K
-----
L
----
P
--
D
GT
W
N
L
K
----
K
T
--
K
D
--
G
K
RE
Y
---
K
---------
P
----------
P
---------
G
--------
T
R
K
----
L
H
N
I
-
L
-
G
---------------
V
E
TGGPGGRRA
G
E
-----------
S
G
H
T
V
A
DYLKFK
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
------------------
179
Blastp_CBE
37.16
32%
-74
- C1 -
-
4YLK
13
DYR1A_HUMAN
A:
[28-357]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
--
Y
I
V
H
L
K
R
H
F
M
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
--
T
P
-
E
L
S
II
H
C
D
L
K
P
E
N
I
L
L
-
C
N
P
-----------------------
K
R
S
A
----------------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
I
Q
S
-
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
------
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
---
D
Q
-
A
P
K
A
R
K
F
F
-
E
--
K
-----
L
----
P
--
D
GT
W
N
L
K
----
K
T
----------
Y
---
K
---------
P
----------
P
---------
G
--------
T
R
K
----
L
H
N
I
-
L
-
G
---------------
V
E
TGGPGGRRA
G
E
-----------
S
G
H
T
V
A
DYLKFK
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
------------------
168
Blastp_CBE
36.12
32%
-74
- C1 -
-
6S1H
4
DYR1A_HUMAN
A:
[28-355]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
--
Y
I
V
H
L
K
R
H
F
M
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
--
T
P
-
E
L
S
II
H
C
D
L
K
P
E
N
I
L
L
-
C
N
P
-----------------------
K
R
S
A
----------------
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
I
Q
S
-
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
------
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
---
D
Q
-
A
P
K
A
R
K
F
F
-
E
--
K
-----
L
----
P
--
D
GT
W
N
L
K
----
K
T
--------------
K
---------
P
----------
P
---------
G
--------
T
R
K
----
L
H
N
I
-
L
-
G
---------------
V
E
TGGPGGRRA
G
E
-----------
S
G
H
T
V
A
DYLKFK
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-------------------