@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DAPK3_HUMAN: (2020-09-07 )
MSTFRQEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRRNVRGEDSGRKPERRRLKTTRLKEYTIKSHSSLPPNNSYADFERFSKVLEEAAAAEEGLRELQRSRRLCHEDVEALAAIYEEKEAWYREESDSLGQDLRRLRQELLKTEALKRQAQEEAKGALLGTSGLKRRFSRLENRYEALAKQVASEMRFVQDLVRALEQEKLQGVECGLR
Atome Classification :
(184 SA)
......--...10.....---..-.20........30........40..--....---..50--........60........70-.-.-......80....----....90........100.-.....--.110.......120.......130.......140.......150.......160...---....170-.-.....---.180-.......---.------190----...-.-...-------..200.......210......---.---220.......-.230---------.......240.......250.......260.......270...------.--------.-------..280--.......290.----......300------------.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MST
F
R
Q
--
E
D
V
E
D
H
Y
E
M
G
---
E
E
-LGS
G
Q
F
A
I
V
R
K
C
R
QKGT
G
K
E
Y
A
A
K
F
--
I
K
K
R
---RL
S
S
--SRRGV
S
R
E
E
I
E
R
E
V
N
I
L
R
E
I-R-H-P
N
I
I
T
L
H
D
I
FEN----KT
D
V
V
L
I
L
E
LVSG
G
E
L
F
D
-
F
L
A
E
K
--ESL
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
SK
R
I
A
H
F
DLKPE
N
I
M
L
L
DKNVPNP
R
I
K
L
I
DFGI
A
---
H
KIEAGN-
E
-
F
K
N
IF---GTP--EFVAPEI---V------N------YEP-L-GLE-------A
D
M
W
S
I
G
V
I
T
Y
I
L
LSGASPFL---G---E-
T
K
Q
E
T
LTN-I
S
A
V---------NYD
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
VKD
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
------
K
--------
A
-------
I
R
RRN--VRGEDSGRK
P
E
----
R
R
R
L
K
T
TRL------------
K
E
Y
T
IKSHSSLPPNNS
Y
A
D
F
E
R
F
S
K
V
L
E
E
A
A
A
A
E
E
G
L
R
E
L
Q
R
S
R
R
L
C
H
E
D
V
E
A
L
A
A
I
Y
E
E
K
E
A
W
YREE
S
D
S
L
G
Q
D
L
R
R
L
R
Q
E
L
L
K
T
E
A
L
K
R
Q
A
Q
E
E
AKGALLG
T
S
G
L
K
R
R
F
S
R
L
E
N
R
Y
E
A
L
A
K
Q
V
A
S
E
M
R
F
V
Q
D
L
V
R
A
L
E
Q
E
K
L
Q
G
VECGLR
23
Blastp_CBE
89.35
100%
-118
- C3 -
-
5VJA
2
DAPK3_HUMAN
B:
[3-272]
----------
V
E
D
H
Y
E
M
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
-----------
R
R
G
V
S
R
E
E
I
E
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
----
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
---
H
K
I
E
A
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
-
T
K
Q
E
T
L
T
N
-
I
S
A
V
---------
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
------
K
--------
A
-------
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
89.22
100%
-117
- C3 -
-
5VJA
2
DAPK3_HUMAN
A:
[3-271]
----------
V
E
D
H
Y
E
M
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
----------
R
R
G
V
S
R
E
E
I
E
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
----
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
---
H
K
I
E
A
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
-
T
K
Q
E
T
L
T
N
-
I
S
A
V
---------
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
------
K
--------
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
88.85
99%
-102
- C3 -
-
1YRP
1
DAPK3_HUMAN
B:
[3-278]
-
S
T
F
R
Q
--
E
D
V
E
D
H
Y
E
M
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
---
R
L
S
S
--
S
R
R
G
V
S
R
E
E
I
E
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
----
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
---
H
K
I
E
A
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
-
T
K
Q
E
T
L
T
N
-
I
S
A
V
---------
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
------
K
--------
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
88.76
99%
-101
- C3 -
-
1YRP
1
DAPK3_HUMAN
A:
[3-278]
-
S
T
F
R
Q
--
E
D
V
E
D
H
Y
E
M
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
---
R
L
S
S
--
S
R
R
G
V
S
R
E
E
I
E
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
----
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
---
H
K
I
E
A
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
-
T
K
Q
E
T
L
T
N
-
I
S
A
V
---------
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
------
K
--------
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
88.68
100%
-114
- C3 -
-
5A6N
4
DAPK3_HUMAN
A:
[3-272]
----------
V
E
D
H
Y
E
M
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
---
R
L
S
S
--
S
R
R
G
V
S
R
E
E
I
E
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
----
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
---
H
K
I
E
A
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
-
T
K
Q
E
T
L
T
N
-
I
S
A
V
---------
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
------
K
--------
A
-------
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
88.12
100%
-119
- C3 -
-
5A6N
1
DAPK3_HUMAN
B:
[3-272]
----------
V
E
D
H
Y
E
M
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
---
R
L
S
S
--
S
R
R
G
V
S
R
E
E
I
E
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
----
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
---
H
K
I
E
-------
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
-
T
K
Q
E
T
L
T
N
-
I
S
A
V
---------
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
------
K
--------
A
-------
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
87.92
74%
-98
- C3 -
-
2YAB
1
DAPK2_MOUSE
B:
[4-302]
--
T
F
K
Q
--
Q
K
V
E
D
F
Y
D
I
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
R
A
--
S
R
R
G
V
C
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
-
L
-
H
-
P
N
I
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
Q
K
--
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
---
H
E
I
E
D
G
V
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
I
T
A
V
---------
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
TPVDTQ
Q
--------
A
-------
M
V
R
R
E
SV
V
N
L
E
N
F
K
K
Q
Y
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
87.76
100%
-119
- C3 -
-
5A6O
2
DAPK3_HUMAN
B:
[3-271]
----------
V
E
D
H
Y
E
M
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
---
R
L
S
S
--
S
R
R
G
V
S
R
E
E
I
E
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
----
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
---
H
K
I
E
-------
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
-
T
K
Q
E
T
L
T
N
-
I
S
A
V
---------
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
------
K
--------
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.74
100%
-107
- C3 -
-
3BHY
1
DAPK3_HUMAN
A:
[3-277]
----------
V
E
D
H
Y
E
M
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
---
R
L
S
S
--
S
R
R
G
V
S
R
E
E
I
E
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
----
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
---
H
K
I
E
----------
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
-
T
K
Q
E
T
L
T
N
-
I
S
A
V
---------
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
------
K
--------
A
-------
I
R
R
R
N
--
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
87.72
100%
-117
- C3 -
-
5A6O
3
DAPK3_HUMAN
A:
[3-272]
----------
V
E
D
H
Y
E
M
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
---
R
L
S
S
--
S
R
R
G
V
S
R
E
E
I
E
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
----
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
---
H
K
I
E
-------
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
-
T
K
Q
E
T
L
T
N
-
I
S
A
V
---------
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
------
K
--------
A
-------
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
87.61
100%
-116
- C3 -
-
5VJA
2
DAPK3_HUMAN
C:
[3-272]
----------
V
E
D
H
Y
E
M
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
---
R
L
S
S
-----
G
V
S
R
E
E
I
E
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
----
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
--
E
K
--
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
--
V
P
N
P
R
I
K
L
I
D
F
G
I
A
---
H
K
I
E
A
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
-
T
K
Q
E
T
L
T
N
-
I
S
A
V
---------
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
------
K
--------
A
-------
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
87.28
74%
-95
- C3 -
-
2YA9
2
DAPK2_MOUSE
B:
[4-302]
--
T
F
K
Q
--
Q
K
V
E
D
F
Y
D
I
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
R
A
--
S
R
R
G
V
C
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
-
L
-
H
-
P
N
I
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
Q
K
--
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
---
H
E
I
E
D
G
V
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
I
T
A
V
---------
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
TPVDTQ
Q
--------
A
-------
M
V
R
R
E
SV
V
N
L
E
N
F
K
K
Q
Y
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
87.21
82%
-112
- C3 -
-
4TL0
2
DAPK1_HUMAN
A:
[4-278]
-
T
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
87.12
100%
-115
- C3 -
-
5VJA
3
DAPK3_HUMAN
D:
[3-271]
----------
V
E
D
H
Y
E
M
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
---
R
L
S
-------
V
S
R
E
E
I
E
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
----
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
----
E
K
--
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
--
V
P
N
P
R
I
K
L
I
D
F
G
I
A
---
H
K
I
E
A
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
-
T
K
Q
E
T
L
T
N
-
I
S
A
V
---------
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
------
K
--------
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
86.93
74%
-92
- C3 -
-
2YA9
2
DAPK2_MOUSE
A:
[4-302]
--
T
F
K
Q
--
Q
K
V
E
D
F
Y
D
I
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
R
A
--
S
R
R
G
V
C
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
-
L
-
H
-
P
N
I
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
Q
K
--
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
---
H
E
I
E
D
G
V
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
I
T
A
V
---------
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
TPVDTQ
Q
--------
A
-------
M
V
R
R
E
SV
V
N
L
E
N
F
K
K
Q
Y
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
86.89
74%
-91
- C3 -
-
2YAA
1
DAPK2_MOUSE
A:
[3-302]
-
E
T
F
K
Q
--
Q
K
V
E
D
F
Y
D
I
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
R
A
--
S
R
R
G
V
C
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
-
L
-
H
-
P
N
I
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
Q
K
--
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
---
H
E
I
E
D
G
V
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
I
T
A
V
---------
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
TPVDTQ
Q
--------
A
-------
M
V
R
R
E
SV
V
N
L
E
N
F
K
K
Q
Y
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
86.81
82%
-110
- C3 -
-
2YAK
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
86.79
74%
-97
- C3 -
-
2YAB
1
DAPK2_MOUSE
A:
[4-302]
--
T
F
K
Q
--
Q
K
V
E
D
F
Y
D
I
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
R
A
--
S
R
R
G
V
C
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
-
L
-
H
-
P
N
I
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
Q
K
--
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
---
H
E
I
E
D
G
V
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
I
T
A
V
---------
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
TPVDTQ
Q
--------
A
-------
M
V
R
R
E
SV
V
N
L
E
N
F
K
K
Q
Y
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
86.76
74%
-95
- C3 -
-
2YAA
1
DAPK2_MOUSE
B:
[4-302]
--
T
F
K
Q
--
Q
K
V
E
D
F
Y
D
I
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
R
A
--
S
R
R
G
V
C
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
-
L
-
H
-
P
N
I
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
Q
K
--
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
---
H
E
I
E
D
G
V
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
I
T
A
V
---------
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
TPVDTQ
Q
--------
A
-------
M
V
R
R
E
SV
V
N
L
E
N
F
K
K
Q
Y
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
585
HHSearch
86.59
77%
-115
- C3 -
-
2A2A
2
DAPK2_HUMAN
B:
[3-282]
-
E
P
F
K
Q
--
Q
K
V
E
D
F
Y
D
I
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
R
A
--
S
R
R
G
V
S
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
-
L
-
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
Q
K
--
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
---
H
E
I
E
D
G
V
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
I
T
S
V
---------
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
------
T
--------
P
-------
V
D
N
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
86.50
100%
-105
- C3 -
-
3BQR
4
DAPK3_HUMAN
A:
[3-278]
----------
V
E
D
H
Y
E
M
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
---
R
L
S
S
--
S
R
R
G
V
S
R
E
E
I
E
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
----
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
---
H
K
I
E
A
G
N
-----
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
-
T
K
Q
E
T
L
T
N
-
I
S
A
V
---------
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
------
K
--------
A
-------
I
R
R
R
N
--
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Blastp_CBE
86.42
82%
-113
- C3 -
-
1WVY
1
DAPK1_HUMAN
A:
[4-276]
---
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
86.42
82%
-105
- C3 -
-
2W4K
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
86.40
82%
-107
- C3 -
-
4TXC
7
DAPK1_HUMAN
A:
[21-295]
-
T
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
86.38
97%
-121
- C3 -
-
2J90
2
DAPK3_HUMAN
A:
[20-293]
----
F
Q
--
S
M
V
E
D
H
Y
E
M
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
---
R
L
S
S
--
S
R
R
G
V
S
R
E
E
I
E
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
----
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
---
H
K
I
E
--------------
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
-
T
K
Q
E
T
L
T
N
-
I
S
A
V
---------
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
------
K
--------
A
-------
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
86.05
82%
-110
- C3 -
-
2Y0A
1
DAPK1_HUMAN
A:
[3-276]
--
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
85.96
82%
-104
- C3 -
-
6FHB
2
DAPK1_HUMAN
A:
[5-279]
-
T
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
85.92
82%
-109
- C3 -
-
4UV0
1
DAPK1_HUMAN
A:
[5-278]
--
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
85.61
81%
-108
- C3 -
-
2XUU
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
A
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
85.42
74%
-100
- C3 -
-
2CKE
1
DAPK2_HUMAN
B:
[3-302]
-
E
P
F
K
Q
--
Q
K
V
E
D
F
Y
D
I
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
R
A
--
S
R
R
G
V
S
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
-
L
-
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
Q
K
--
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
---
H
E
I
E
D
G
V
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
I
T
S
V
---------
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
------
T
--------
P
VDNQQAM
V
R
R
E
S
--
V
V
N
L
E
N
F
R
K
Q
Y
----
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
85.18
82%
-103
- C3 -
-
5AV0
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
---
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
85.06
82%
-106
- C3 -
-
4B4L
3
DAPK1_HUMAN
A:
[7-278]
----
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
586
HHSearch
84.88
82%
-103
- C3 -
-
4PF4
6
DAPK1_HUMAN
A:
[3-277]
-
T
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Blastp_CBE
84.84
82%
-102
- C3 -
-
2W4J
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
84.78
82%
-104
- C3 -
-
6QN4
4
DAPK1_HUMAN
A:
[5-279]
-
T
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
84.74
82%
-102
- C3 -
-
4PF4
6
DAPK1_HUMAN
A:
[2-277]
M
T
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
84.64
82%
-103
- C3 -
-
5AV2
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
---
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
84.51
74%
-96
- C3 -
-
2CKE
1
DAPK2_HUMAN
C:
[3-302]
-
E
P
F
K
Q
--
Q
K
V
E
D
F
Y
D
I
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
R
A
--
S
R
R
G
V
S
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
-
L
-
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
Q
K
--
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
---
H
E
I
E
D
G
V
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
I
T
S
V
---------
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
------
T
--------
P
VDNQQAM
V
R
R
E
S
--
V
V
N
L
E
N
F
R
K
Q
Y
----
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
84.46
82%
-106
- C3 -
-
5AUX
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
---
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
84.45
74%
-95
- C3 -
-
2CKE
1
DAPK2_HUMAN
A:
[2-302]
M
E
P
F
K
Q
--
Q
K
V
E
D
F
Y
D
I
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
R
A
--
S
R
R
G
V
S
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
-
L
-
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
Q
K
--
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
---
H
E
I
E
D
G
V
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
I
T
S
V
---------
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
------
T
--------
P
VDNQQAM
V
R
R
E
S
--
V
V
N
L
E
N
F
R
K
Q
Y
----
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
84.42
74%
-94
- C3 -
-
2CKE
1
DAPK2_HUMAN
D:
[3-302]
-
E
P
F
K
Q
--
Q
K
V
E
D
F
Y
D
I
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
S
R
A
--
S
R
R
G
V
S
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
-
L
-
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
Q
K
--
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
---
H
E
I
E
D
G
V
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
I
T
S
V
---------
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
------
T
--------
P
VDNQQAM
V
R
R
E
S
--
V
V
N
L
E
N
F
R
K
Q
Y
----
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
84.40
82%
-105
- C3 -
-
5AV3
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
---
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
84.21
82%
-102
- C3 -
-
5AUV
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
---
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
84.20
82%
-103
- C3 -
-
5AUZ
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
----
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
84.17
82%
-107
- C3 -
-
6QMO
7
DAPK1_HUMAN
A:
[7-279]
---
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
84.13
82%
-105
- C3 -
-
5AUW
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
84.07
82%
-101
- C3 -
-
5AUY
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
---
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
84.07
82%
-103
- C3 -
-
5AUT
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
----
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
84.06
82%
-104
- C3 -
-
5AUU
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
----
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
83.91
82%
-106
- C3 -
-
5AV4
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
----
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
82.93
82%
-107
- C3 -
-
6AAR
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
----------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
78.77
82%
-115
- C3 -
-
3ZXT
1
DAPK1_HUMAN
B:
[7-276]
--------
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
---
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
---------------
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
-
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
---
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
77.76
82%
-118
- C3 -
-
3ZXT
1
DAPK1_HUMAN
C:
[5-276]
----
R
Q
--
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
--
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
K
S
--
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
----------------
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
77.37
82%
-138
- C3 -
-
3ZXT
1
DAPK1_HUMAN
D:
[7-276]
--------
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
----------------
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
---------------
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
76.61
82%
-123
- C3 -
-
3ZXT
1
DAPK1_HUMAN
A:
[7-276]
--------
E
N
V
D
D
Y
Y
D
T
G
---
E
E
-
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
T
----------
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
V
P
K
P
R
I
K
I
I
D
F
G
L
A
---
H
K
I
D
-------------------
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
-
T
K
Q
E
T
L
A
N
-
V
S
A
V
---------
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
70.18
33%
-53
- C3 -
-
3SOA
1
KCC2A_HUMAN
A:
[7-351]
--------
T
R
F
T
E
E
Y
Q
L
F
---
E
E
-
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
--
I
N
T
K
---
K
L
S
A
--
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
----
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
-
L
K
G
A
A
V
K
L
A
D
F
G
L
A
---
I
E
V
E
G
E
Q
-
Q
A
W
F
G
F
A
---
G
T
P
--
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-
Y
-
G
K
P
-------
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
-
D
Q
H
R
L
Y
Q
Q
-
I
K
A
G
---------
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
------
S
HRSTVA--
S
-------
C
M
H
R
Q
--
E
T
V
D
C
L
K
K
F
N
A
----
R
R
K
L
K
G
A
I
L
TVMLATRNFSVR
K
Q
E
I
I
K
V
T
E
Q
L
I
E
A
I
S
N
G
D
F
E
S
Y
T
K
M
C
D
P
G
M
T
A
F
E
---------------------------------------------------------------------------------------------------------------------
115
Blastp_CBE
69.06
41%
-153
- C3 -
-
4FG9
1
KCC1A_HUMAN
B:
[14-276]
--------
E
D
I
R
D
I
Y
D
F
R
---
D
V
-
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
----------------------
E
I
A
V
L
H
K
I
-
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
V
E
K
--
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
--------------
V
-
L
S
T
A
C
---
G
T
P
--
G
Y
V
A
P
E
V
---
L
------
A
------
Q
K
P
-
Y
-
S
K
A
-------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
---
E
-
N
D
A
K
L
F
E
Q
-
I
L
K
A
---------
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
68.97
38%
-83
- C3 -
-
5VLO
2
KCC2D_HUMAN
B:
[8-273]
-----
C
--
T
R
F
T
D
E
Y
Q
L
F
---
E
E
-
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
S
A
--
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
---
I
E
V
Q
G
D
Q
-
Q
A
W
F
G
F
A
---
G
T
P
--
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-
Y
-
G
K
P
-------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
-
D
Q
H
R
L
Y
Q
Q
-
I
K
A
G
---------
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
Blastp_CBE
68.80
41%
-145
- C3 -
-
4FG8
1
KCC1A_HUMAN
B:
[14-276]
--------
E
D
I
R
D
I
Y
D
F
R
---
D
V
-
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
---------------------
N
E
I
A
V
L
H
K
I
-
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
V
E
K
--
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
G
----------
G
S
-
V
-
L
S
T
A
C
---
G
T
P
--
G
Y
V
A
P
E
V
---
L
------
A
------
Q
K
P
-
Y
-
S
K
A
-------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
---
E
-
N
D
A
K
L
F
E
Q
-
I
L
K
A
---------
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
Blastp_CBE
68.35
38%
-88
- C3 -
-
6AYW
2
KCC2D_HUMAN
B:
[8-273]
-----
C
--
T
R
F
T
D
E
Y
Q
L
F
---
E
E
-
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
S
A
--
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
---
I
E
V
Q
G
D
Q
-
Q
A
W
F
G
F
A
---
G
T
P
--
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-
Y
-
G
K
P
-------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
-
D
Q
H
R
L
Y
Q
Q
-
I
K
A
G
---------
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Blastp_CBE
68.20
41%
-150
- C3 -
-
4FG8
1
KCC1A_HUMAN
A:
[12-276]
----
Q
A
--
E
D
I
R
D
I
Y
D
F
R
---
D
V
-
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
--------------------
E
N
E
I
A
V
L
H
K
I
-
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
V
E
K
--
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
-------------------------
T
P
--
G
Y
V
A
P
E
V
---
L
------
A
------
Q
K
P
-
Y
-
S
K
A
-------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
---
E
-
N
D
A
K
L
F
E
Q
-
I
L
K
A
---------
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
67.65
41%
-145
- C3 -
-
4FG7
1
KCC1A_HUMAN
A:
[12-276]
----
Q
A
--
E
D
I
R
D
I
Y
D
F
R
---
D
V
-
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
-------------------
S
M
E
N
E
I
A
V
L
H
K
I
-
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
V
E
K
--
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
G
L
S
---
K
M
E
D
P
-------------
G
T
P
--
G
Y
V
A
P
E
V
---
L
------
A
------
Q
K
----
S
K
A
-------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
---
E
-
N
D
A
K
L
F
E
Q
-
I
L
K
A
---------
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
67.52
38%
-86
- C3 -
-
2VN9
1
KCC2D_HUMAN
B:
[2-264]
----------
M
T
D
E
Y
Q
L
F
---
E
E
-
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
S
A
--
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
---
I
E
V
Q
G
D
Q
-
Q
A
W
F
G
F
A
---
G
T
P
--
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-
Y
-
G
K
P
-------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
-
D
Q
H
R
L
Y
Q
Q
-
I
K
A
G
---------
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
588
HHSearch
67.33
39%
-90
- C3 -
-
2WEL
7
KCC2D_HUMAN
A:
[2-273]
----------
M
T
D
E
Y
Q
L
F
---
E
E
-
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
S
A
------
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
---
I
E
V
Q
G
D
Q
Q
A
-
W
F
G
F
A
---
G
T
P
--
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-
Y
-
G
K
P
-------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
-
D
Q
H
R
L
Y
Q
Q
-
I
K
A
G
---------
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
------
C
--------
Q
-------
R
S
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
67.23
38%
-87
- C3 -
-
2VN9
2
KCC2D_HUMAN
A:
[2-264]
----------
M
T
D
E
Y
Q
L
F
---
E
E
-
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
S
A
--
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
---
I
E
V
Q
G
D
Q
-
Q
A
W
F
G
F
A
---
G
T
P
--
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-
Y
-
G
K
P
-------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
-
D
Q
H
R
L
Y
Q
Q
-
I
K
A
G
---------
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
67.06
38%
-92
- C3 -
-
2WEL
7
KCC2D_HUMAN
A:
[2-268]
----------
M
T
D
E
Y
Q
L
F
---
E
E
-
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
S
A
--
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
---
I
E
V
Q
G
D
Q
-
Q
A
W
F
G
F
A
---
G
T
P
--
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-
Y
-
G
K
P
-------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
-
D
Q
H
R
L
Y
Q
Q
-
I
K
A
G
---------
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
67.06
38%
-89
- C3 -
-
6AYW
2
KCC2D_HUMAN
A:
[9-273]
--------
T
R
F
T
D
E
Y
Q
L
F
---
E
E
-
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
S
A
--
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
---
I
E
V
Q
G
D
Q
-
Q
A
W
F
G
F
A
---
G
T
P
--
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-
Y
-
G
K
P
-------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
-
D
Q
H
R
L
Y
Q
Q
-
I
K
A
G
---------
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
67.00
36%
-99
- C3 -
-
3BHH
1
KCC2B_HUMAN
A:
[2-264]
----------
M
T
D
E
Y
Q
L
Y
---
E
D
-
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
S
A
--
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
-
H
-
S
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
C
K
G
A
A
V
K
L
A
D
F
G
L
A
---
I
E
V
Q
G
D
Q
-
Q
A
W
F
G
F
A
---
G
T
P
--
G
Y
L
S
P
E
V
---
L
------
R
------
K
E
A
-
Y
-
G
K
P
-------
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
-
D
Q
H
K
L
Y
Q
Q
-
I
K
A
G
---------
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
66.71
36%
-100
- C3 -
-
3BHH
1
KCC2B_HUMAN
B:
[2-264]
----------
M
T
D
E
Y
Q
L
Y
---
E
D
-
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
S
A
--
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
-
H
-
S
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
C
K
G
A
A
V
K
L
A
D
F
G
L
A
---
I
E
V
Q
G
D
Q
-
Q
A
W
F
G
F
A
---
G
T
P
--
G
Y
L
S
P
E
V
---
L
------
R
------
K
E
A
-
Y
-
G
K
P
-------
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
-
D
Q
H
K
L
Y
Q
Q
-
I
K
A
G
---------
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
179
Blastp_CBE
66.70
38%
-92
- C3 -
-
3F3Z
5
?
A:
[6-265]
---------
D
I
N
Q
Y
Y
T
L
E
---
N
T
-
I
G
R
G
S
W
G
E
V
K
I
A
V
Q
K
G
T
R
I
R
R
A
A
K
K
--
I
P
K
Y
---
F
V
E
D
--
V
D
R
------
F
K
Q
E
I
E
I
M
K
S
L
-
D
-
H
-
P
N
I
I
R
L
Y
E
T
F
E
D
----
N
T
D
I
Y
L
V
M
E
L
C
T
G
G
E
L
F
E
-
R
V
V
H
K
--
R
V
F
R
E
S
D
A
A
R
I
M
K
D
V
L
S
A
V
A
Y
C
H
K
L
N
V
A
H
R
D
L
K
P
E
N
F
L
F
L
-
T
D
S
P
D
S
P
L
K
L
I
D
F
G
L
A
---
A
R
F
K
P
G
K
-
M
-
M
R
T
K
V
---
G
T
P
--
Y
Y
V
S
P
Q
V
---
L
------
E
GL----
Y
G
P
-----
E
-------
C
D
E
W
S
A
G
V
M
M
Y
V
L
L
C
G
Y
P
P
F
S
---
A
---
P
-
T
-
D
E
V
M
L
K
-
I
R
E
G
---------
T
F
T
F
P
E
K
D
W
L
N
V
S
P
Q
A
E
S
L
I
R
R
L
L
T
K
S
P
K
Q
R
I
T
S
L
Q
A
L
E
H
E
W
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
66.59
39%
-95
- C3 -
-
5JZN
1
DCLK1_HUMAN
A:
[17-279]
----------
I
T
E
R
Y
K
V
G
---
R
T
-
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
--
I
K
K
S
---
K
C
------
R
G
-
K
E
H
M
I
Q
N
E
V
S
I
L
R
R
V
-
K
-
H
-
P
N
I
V
L
L
I
E
E
M
D
V
----
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
-
A
I
T
S
T
--
N
K
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
---
T
I
V
D
G
---
P
-
L
Y
T
V
C
---
G
T
P
--
T
Y
V
A
P
E
I
---
I
------
A
------
E
T
G
-
Y
-
G
L
K
-------
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
---
G
---
S
--
D
Q
E
V
L
F
D
Q
I
L
M
G
---------
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
V
Q
V
L
E
H
P
W
V
------
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
66.55
38%
-84
- C3 -
-
6BAB
2
KCC2D_MOUSE
A:
[12-273]
-----------
T
D
E
Y
Q
L
F
---
E
E
-
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
S
A
--
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
---
I
E
V
Q
G
D
Q
-
Q
A
W
F
G
F
A
---
G
T
P
--
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-
Y
-
G
K
P
-------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
-
D
Q
H
R
L
Y
Q
Q
-
I
K
A
G
---------
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
66.36
98%
-36
- C3 -
-
2J90
3
DAPK3_HUMAN
B:
[27-295]
-------------
H
Y
E
M
G
---
E
E
-
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
----
K
E
Y
A
A
K
F
--
I
K
K
R
---
R
L
S
S
---
R
R
G
V
S
R
E
E
I
E
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
----
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
--
E
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
---
H
K
I
E
A
G
N
-
E
-
F
K
N
I
F
---
G
T
P
--
E
F
V
A
P
E
I
---
V
------
N
------
Y
E
P
-
L
-
G
L
E
-------
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
-
T
K
Q
E
T
L
T
N
-
I
S
A
V
---------
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-
I
A
Q
S
L
E
H
S
W
I
------
K
--------
A
-------
I
R
R
R
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Blastp_CBE
66.24
38%
-86
- C3 -
-
5VLO
2
KCC2D_HUMAN
A:
[9-273]
--------
T
R
F
T
D
E
Y
Q
L
F
---
E
E
-
L
G
---
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
S
A
--
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
---
I
E
V
Q
G
D
Q
-
Q
A
W
F
G
F
A
---
G
T
P
--
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-
Y
-
G
K
P
-------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
-
D
Q
H
R
L
Y
Q
Q
-
I
K
A
G
---------
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
66.23
41%
-150
- C3 -
-
4FG9
1
KCC1A_HUMAN
A:
[12-276]
----
Q
A
--
E
D
I
R
D
I
Y
D
F
R
---
D
V
-
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
E
-------------------
E
N
E
I
A
V
L
H
K
I
-
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
V
E
K
--
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
--------------------------
P
--
G
Y
V
A
P
E
V
---
L
------
A
------
Q
K
P
-
Y
-
S
K
A
-------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
---
E
-
N
D
A
K
L
F
E
Q
-
I
L
K
A
---------
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
66.21
38%
-90
- C3 -
-
6BAB
2
KCC2D_MOUSE
B:
[14-273]
-------------
E
Y
Q
L
F
---
E
E
-
L
G
----
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
S
A
--
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
---
I
E
V
Q
G
D
Q
-
Q
A
W
F
G
F
A
---
G
T
P
--
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-
Y
-
G
K
P
-------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
-
D
Q
H
R
L
Y
Q
Q
-
I
K
A
G
---------
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
66.11
39%
-94
- C3 -
-
5JZN
1
B:
[17-279]
----------
I
T
E
R
Y
K
V
G
---
R
T
-
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
--
I
K
K
S
---
K
C
------
R
G
-
K
E
H
M
I
Q
N
E
V
S
I
L
R
R
V
-
K
-
H
-
P
N
I
V
L
L
I
E
E
M
D
V
----
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
-
A
I
T
S
T
--
N
K
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
---
T
I
V
D
G
---
P
-
L
Y
T
V
C
---
G
T
P
--
T
Y
V
A
P
E
I
---
I
------
A
------
E
T
G
-
Y
-
G
L
K
-------
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
---
G
---
S
---
Q
E
V
L
F
D
Q
I
L
M
G
---------
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
V
Q
V
L
E
H
P
W
V
------
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
65.68
39%
-77
- C3 -
-
2V7O
3
KCC2G_HUMAN
A:
[31-291]
------------
D
D
Y
Q
L
F
---
E
E
-
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
S
A
--
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
C
K
G
A
A
V
K
L
A
D
F
G
L
A
-----
I
E
V
Q
G
-
E
-
Q
Q
A
W
F
GFA
G
T
P
--
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-
Y
-
G
K
P
-------
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
-
D
Q
H
K
L
Y
Q
Q
-
I
K
A
G
---------
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
65.32
39%
-98
- C3 -
-
5JZJ
2
DCLK1_HUMAN
A:
[34-296]
----------
I
T
E
R
Y
K
V
G
---
R
T
-
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
--
I
K
K
S
---
K
C
------
R
G
-
K
E
H
M
I
Q
N
E
V
S
I
L
R
R
V
-
K
-
H
-
P
N
I
V
L
L
I
E
E
M
D
V
----
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
-
A
I
T
S
T
--
N
K
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
---
T
I
V
D
G
---
P
-
L
Y
T
V
C
---
G
T
P
--
T
Y
V
A
P
E
I
---
I
------
A
------
E
T
G
-
Y
-
G
L
K
-------
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
---
G
---
S
----
E
V
L
F
D
Q
I
L
M
G
---------
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
V
Q
V
L
E
H
P
W
V
------
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
65.28
38%
-85
- C3 -
-
5FG8
3
KCC2A_DROME
A:
[14-274]
------------
D
N
Y
D
I
K
---
E
E
-
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
--
I
N
T
K
---
K
L
T
A
--
R
----
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
-
H
-
H
-
P
N
I
V
R
L
H
D
S
I
Q
E
----
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
A
K
G
A
A
V
K
L
A
D
F
G
L
A
---
I
E
V
Q
G
D
H
-
Q
A
W
F
G
F
A
---
G
T
P
--
G
Y
L
S
P
E
V
---
L
------
K
------
K
E
P
-
Y
-
G
K
S
-------
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
-
D
Q
H
R
L
Y
S
Q
-
I
K
A
G
---------
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
T
A
A
E
A
L
K
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
65.28
38%
-84
- C3 -
-
6BAB
2
KCC2D_MOUSE
C:
[14-273]
-------------
E
Y
Q
L
F
---
E
E
-
L
G
K
G
A
F
S
V
V
R
R
C
M
K
----
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
S
A
--
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
---
I
E
V
Q
G
D
Q
-
Q
A
W
F
G
F
A
---
G
T
P
--
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-
Y
-
G
K
P
-------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
-
D
Q
H
R
L
Y
Q
Q
-
I
K
A
G
---------
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
65.09
39%
-97
- C3 -
-
5JZJ
1
B:
[34-296]
----------
I
T
E
R
Y
K
V
G
---
R
T
-
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
--
I
K
K
S
---
K
C
------
R
G
-
K
E
H
M
I
Q
N
E
V
S
I
L
R
R
V
-
K
-
H
-
P
N
I
V
L
L
I
E
E
M
D
V
----
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
-
A
I
T
S
T
--
N
K
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
---
T
I
V
D
G
---
P
-
L
Y
T
V
C
---
G
T
P
--
T
Y
V
A
P
E
I
---
I
------
A
------
E
T
G
-
Y
-
G
L
K
-------
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
------------
E
V
L
F
D
Q
I
L
M
G
---------
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
V
Q
V
L
E
H
P
W
V
------
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
64.74
38%
-84
- C3 -
-
5HU3
1
KCC2A_DROME
A:
[14-274]
------------
D
N
Y
D
I
K
---
E
E
-
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
--
I
N
T
K
---
K
L
T
A
--
R
----
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
-
H
-
H
-
P
N
I
V
R
L
H
D
S
I
Q
E
----
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
-
A
K
G
A
A
V
K
L
A
D
F
G
L
A
---
I
E
V
Q
G
D
H
-
Q
A
W
F
G
F
A
---
G
T
P
--
G
Y
L
S
P
E
V
---
L
------
K
------
K
E
P
-
Y
-
G
K
S
-------
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
-
D
Q
H
R
L
Y
S
Q
-
I
K
A
G
---------
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
T
A
A
E
A
L
K
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
64.33
38%
-84
- C3 -
-
5H9B
2
KCC2A_DROME
A:
[14-274]
------------
D
N
Y
D
I
K
---
E
E
-
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
--
I
N
T
K
---
K
L
T
A
--
R
----
D
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
-
H
-
H
-
P
N
I
V
R
L
H
D
S
I
Q
E
----
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
A
K
G
A
A
V
K
L
A
D
F
G
L
A
---
I
E
V
Q
G
D
H
-
Q
A
W
F
G
F
A
---
G
T
P
--
G
Y
L
S
P
E
V
---
L
------
K
------
K
E
P
-
Y
-
G
K
S
-------
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
-
D
Q
H
R
L
Y
S
Q
-
I
K
A
G
---------
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
T
A
A
E
A
L
K
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
180
Blastp_CBE
64.05
37%
-67
- C3 -
-
3HX4
3
?
A:
[50-317]
------------
D
R
Y
K
G
Q
---
R
V
-
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
---------------
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
--
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
S
K
-
K
-
M
K
D
K
I
---
G
T
A
--
Y
Y
I
A
P
E
V
---
L
------
H
GT----
Y
D
E
-----
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
-
N
E
Y
D
I
L
K
K
-
V
E
K
G
---------
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------
Q
--------
T
-------
Y
T
K
E
Q
--
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
63.04
39%
-66
- C3 -
-
3LIJ
1
?
A:
[29-475]
--
T
S
K
K
--
G
H
L
S
E
M
Y
Q
R
V
---
K
K
-
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
--
I
R
K
----------
S
----
S
N
S
K
L
L
E
E
V
A
V
L
K
L
L
-
D
-
H
-
P
N
I
M
K
L
Y
D
F
F
E
D
----
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
-
E
I
I
H
R
--
M
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
E
-
K
D
A
L
I
K
I
V
D
F
G
L
S
---
A
V
F
E
N
Q
K
-
K
-
M
K
E
R
L
---
G
T
A
--
Y
Y
I
A
P
E
V
---
L
RK----
K
------
Y
D
E
-----
K
-------
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
---
G
---
Q
-
T
D
Q
E
I
L
R
K
-
V
E
K
G
---------
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
------
K
--------
E
-------
M
C
S
K
K
--
E
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
63.02
37%
-66
- C3 -
-
2WEI
1
?
A:
[15-281]
---
Y
F
Q
--
G
T
F
A
E
R
Y
N
I
V
---
C
M
-
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
-------
A
--
S
A
K
N
K
D
T
S
T
I
L
R
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
-
E
I
I
K
R
--
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
---
T
C
F
Q
Q
N
T
-
K
-
M
K
D
R
I
---
G
T
A
--
Y
Y
I
A
P
E
V
---
L
RG----
T
------
Y
D
E
-----
K
-------
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
---
G
---
K
-
N
E
Y
D
I
L
K
R
-
V
E
T
G
---------
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
62.88
37%
-66
- C3 -
-
4IEB
1
?
A:
[49-317]
------------
D
R
Y
K
G
Q
---
R
V
-
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
V
--------
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
----
K
G
Y
F
Y
L
V
M
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
--
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
S
K
-
K
-
M
K
D
K
I
---
G
T
A
--
Y
Y
I
A
P
E
V
---
L
------
H
GT----
Y
D
E
-----
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
-
N
E
Y
D
I
L
K
K
-
V
E
K
G
---------
K
Y
T
F
E
-
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------
Q
--------
T
-------
Y
T
K
E
Q
--
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
425
Blastp_CBE
62.75
33%
-120
- C3 -
-
2WTW
1
AURKA_HUMAN
A:
[10-271]
--------
W
A
L
E
D
-
F
E
I
G
---
R
P
-
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
L
E
K
--
A
--
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
-
E
L
Q
K
L
--
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
---
V
H
A
P
S
---------
C
---
G
T
L
--
D
Y
L
P
P
E
M
---
I
------
E
------
G
R
M
-
H
-
D
E
K
-------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
---
A
---
N
-
T
Y
Q
E
T
Y
K
R
-
I
S
R
V
---------
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
------
T
--------
A
NS-----
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
62.60
44%
-124
- C3 -
-
2JAM
3
KCC1G_HUMAN
A:
[15-265]
---------------------
E
V
-
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
--
I
K
K
--------------
S
S
---
L
E
N
E
I
A
V
L
K
K
I
-
K
-
H
-
E
N
I
V
T
L
E
D
I
Y
E
S
----
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
L
E
R
--
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
S
----
K
M
E
Q
N
G
-
I
-
M
S
T
A
C
---
G
T
P
--
G
Y
V
A
P
E
V
---
L
------
A
------
Q
K
P
-
Y
-
S
K
A
-------
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
---
E
---
E
-
T
E
S
K
L
F
E
K
-
I
K
E
G
---------
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
62.36
35%
-99
- C3 -
-
5O1S
2
A:
[44-303]
------------
D
G
Y
E
V
K
---
E
D
-
I
-----
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
--
I
D
K
S
---
K
R
D
P
--
T
------
E
E
I
E
I
---
L
L
R
Y
G
-
Q
-
H
-
P
N
I
I
T
L
K
D
V
Y
D
D
----
G
K
Y
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
-
K
I
L
R
Q
--
K
F
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
N
P
E
S
I
R
I
C
D
F
G
F
A
---
K
Q
L
R
A
E
N
-----
G
L
L
---
M
T
P
C-
N
F
V
A
P
E
V
---
L
------
E
------
R
Q
G
-
Y
-
D
A
A
-------
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
---
N
GPD
D
-
T
P
E
E
I
L
A
R
-
I
G
S
G
---------
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
62.30
33%
-144
- C3 -
-
4BL1
1
MELK_HUMAN
A:
[11-264]
-------------
Y
Y
E
L
H
---
E
T
-
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
---
T
L
----------
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
--
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
---
A
K
-----------------
S
L
--
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
----
G
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
-
N
V
M
A
L
Y
K
K
-
I
M
R
G
---------
K
Y
D
V
-
P
K
W
L
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
219
Blastp_CBE
62.17
38%
-65
- C3 -
-
4YSJ
1
?
B:
[30-293]
------------
D
R
Y
K
G
Q
---
R
V
-
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
--
I
S
K
R
------------------
L
L
K
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
----
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
--
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
N
K
R
-
K
D
A
N
I
R
I
I
D
F
G
L
S
---
T
H
F
E
S
T
K
-
K
-
M
K
D
K
I
---
G
T
A
--
Y
Y
I
A
P
E
V
---
L
------
H
GT----
Y
D
E
-----
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
-
N
E
F
D
I
L
K
K
-
V
E
K
G
---------
K
F
T
F
D
L
P
Q
W
K
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
S
A
R
D
A
L
E
H
E
W
L
------
K
--------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
62.03
38%
-74
- C3 -
-
3MWU
1
?
A:
[24-301]
--------------
Y
N
I
V
---
C
M
-
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
-------
A
--
S
A
K
N
K
D
T
S
T
I
L
R
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
-
E
I
I
K
R
--
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
---
T
C
F
Q
Q
N
------
D
R
I
---
G
T
A
--
Y
Y
I
A
P
E
V
---
L
RG----
T
------
Y
D
E
-----
K
-------
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
---
G
---
K
-
N
E
Y
D
I
L
K
R
-
V
E
T
G
---------
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
62.03
37%
-51
- C3 -
-
3I7B
4
?
A:
[26-296]
------------
D
R
Y
K
G
Q
---
R
V
-
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
V
-----
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
--
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
S
K
-
K
-
M
K
D
K
I
---
G
T
A
--
Y
Y
I
A
P
E
V
---
L
------
H
GT----
Y
D
E
-----
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
-
N
E
Y
D
I
L
K
K
-
V
E
K
G
---------
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------
Q
--------
T
-------
Y
T
K
E
Q
--
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
61.95
44%
-120
- C3 -
-
2JAM
3
KCC1G_HUMAN
B:
[15-265]
---------------------
E
V
-
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
--
I
K
K
--------------
S
S
---
L
E
N
E
I
A
V
L
K
K
I
-
K
-
H
-
E
N
I
V
T
L
E
D
I
Y
E
S
----
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
L
E
R
--
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
S
----
K
M
E
Q
N
G
-
I
-
M
S
T
A
C
---
G
T
P
--
G
Y
V
A
P
E
V
---
L
------
A
------
Q
K
P
-
Y
-
S
K
A
-------
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
---
E
---
E
-
T
E
S
K
L
F
E
K
-
I
K
E
G
---------
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
61.70
33%
-146
- C3 -
-
4BKY
1
MELK_HUMAN
A:
[11-264]
-------------
Y
Y
E
L
H
---
E
T
-
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
---
T
L
---------
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
--
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
---
A
------------------
S
L
--
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
----
G
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
-
N
V
M
A
L
Y
K
K
-
I
M
R
G
---------
K
Y
D
V
-
P
K
W
L
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
172
Blastp_CBE
61.66
37%
-51
- C3 -
-
3N51
3
?
A:
[26-308]
------------
D
R
Y
K
G
Q
---
R
V
-
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
V
-----
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
--
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
S
K
-
K
-
M
K
D
K
I
---
G
T
A
--
Y
Y
I
A
P
E
V
---
L
------
H
GT----
Y
D
E
-----
K
-------
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
-
N
E
Y
D
I
L
K
K
-
V
E
K
G
---------
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------
Q
--------
T
-------
Y
T
K
E
Q
--
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
197
Blastp_CBE
61.53
38%
-69
- C3 -
-
4Y5Q
1
?
A:
[24-301]
--------------
Y
N
I
V
---
C
M
-
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
-------
A
--
S
A
K
N
K
D
T
S
T
I
L
R
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
-
E
I
I
K
R
--
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
---
T
C
F
Q
Q
N
T
-----
D
R
I
---
G
T
A
--
Y
Y
I
A
P
E
V
---
L
RG----
T
------
Y
D
E
-----
K
-------
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
---
G
---
K
-
N
E
Y
D
I
L
K
R
-
V
E
T
G
---------
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
382
Blastp_CBE
61.51
33%
-156
- C3 -
-
4BKZ
1
MELK_HUMAN
A:
[11-264]
-------------
Y
Y
E
L
H
---
E
T
-
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
---
T
L
----------
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
--
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
---
A
------------------
S
L
--
A
Y
A
A
P
E
L
---
I
------
Q
------
G
-----
G
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
-
N
V
M
A
L
Y
K
K
-
I
M
R
G
---------
K
Y
D
V
-
P
K
W
L
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
595
HHSearch
61.44
44%
-52
- C3 -
-
2X4F
4
MYLK4_HUMAN
A:
[89-352]
------------
Y
T
V
S
K
T
---
E
I
-
L
-----
G
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
--
I
K
T
R
---
G
M
K
--------
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
-
D
-
H
-
A
N
L
I
Q
L
Y
D
A
F
E
S
----
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
-
R
I
I
D
E
S-
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
--
A
K
Q
I
K
I
I
D
F
G
L
A
---
R
R
Y
K
P
R
E
-
K
-
L
K
V
N
F
---
G
T
P
--
E
F
L
A
P
E
V
---
V
------
N
------
Y
D
F
-
V
-
S
F
P
-------
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
---
G
---
D
-
N
D
A
E
T
L
N
N
-
I
L
A
C
---------
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
------
S
--------
D
-------
H
K
L
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
61.28
33%
-145
- C3 -
-
5MAG
3
MELK_HUMAN
A:
[11-264]
-------------
Y
Y
E
L
H
---
E
T
-
I
G
T
G
G
-
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
---
T
L
---------
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
--
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
---
A
K
-----------------
S
L
--
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
--
L
-
G
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
-
N
V
M
A
L
Y
K
K
-
I
M
R
G
---------
K
Y
D
V
-
P
K
W
L
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
379
Blastp_CBE
60.97
33%
-138
- C3 -
-
5MAF
2
MELK_HUMAN
A:
[11-264]
-------------
Y
Y
E
L
H
---
E
T
-
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
---
T
L
---------
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
--
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
---
A
K
-----------------
S
L
--
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
--
L
-
G
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
-
N
V
M
A
L
Y
K
K
-
I
M
R
G
---------
K
Y
D
V
-
P
K
W
L
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
Blastp_CBE
60.89
41%
-80
- C3 -
-
2W4O
1
KCC4_HUMAN
A:
[48-336]
-----
R
--
D
A
L
S
D
F
F
E
V
E
---
S
E
-
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
--
L
K
K
-----------------------
I
G
V
L
L
R
L
-
S
-
H
-
P
N
I
I
K
L
K
E
I
F
E
T
----
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
-
R
I
V
E
K
--
G
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
A
T
P
A
P
D
A
P
L
K
I
A
D
F
------------------------
G
T
P
--
G
Y
C
A
P
E
I
---
L
------
R
------
G
C
A
-
Y
-
G
P
E
-------
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
---
D
---
E
R
G
D
Q
F
M
F
R
R
-
I
L
N
C
---------
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
------
T
--------
G
-------
K
A
A
N
F
--
V
H
M
D
T
A
Q
K
K
L
Q
EFNA
R
R
K
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
274
Blastp_CBE
60.78
36%
-90
- C3 -
-
2CN5
1
CHK2_HUMAN
A:
[7-285]
M
S
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
R
-----------------
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
Blastp_CBE
60.76
48%
-32
- C3 -
-
6QF4
2
ST17B_HUMAN
A:
[34-292]
-----------------
S
---
K
E
-
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
--
L
K
K
R
---
R
------
R
G
Q
D
C
R
A
E
I
L
H
E
I
A
V
L
E
L
A
-
K
-
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
----
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
-
L
C
L
P
E
LA
E
M
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
-
L
L
S
S
I
Y
P
L
G
D
I
K
I
V
D
F
G
M
S
---
R
K
I
G
H
A
C
------
I
M
---
G
T
P
--
E
Y
L
A
P
E
I
---
L
------
N
------
Y
D
P
-
I
-
T
T
A
-------
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
---
G
---
E
-
D
N
Q
E
T
Y
L
N
-
I
S
Q
V
---------
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
60.71
38%
-75
- C3 -
-
3NCG
1
?
A:
[24-318]
--------------
Y
N
I
V
---
C
M
-
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
-------
A
--
S
A
K
N
K
D
T
S
T
I
L
R
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
-
E
I
I
K
R
--
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
---
T
C
F
Q
Q
N
T
-------
I
---
G
T
A
--
Y
Y
I
A
P
E
V
---
L
RG----
T
------
Y
D
E
-----
K
-------
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
---
G
---
K
-
N
E
Y
D
I
L
K
R
-
V
E
T
G
---------
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
60.50
36%
-81
- C3 -
-
4A9T
4
CHK2_HUMAN
A:
[7-285]
M
S
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
---------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
208
Blastp_CBE
60.47
37%
-6
- C3 -
-
2Y7J
1
PHKG2_HUMAN
D:
[96-364]
--------------
Y
D
P
K
---
D
V
-
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
ME
V
------
R
L
S
P
--
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
-
A
G
H
-
P
H
I
I
T
L
I
D
S
Y
E
S
----
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
-
Y
L
T
E
K
--
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
----
N
M
Q
I
R
L
S
D
F
G
F
S
---
C
H
L
E
P
G
E
-
K
-
L
R
E
L
C
---
G
T
P
--
G
Y
L
A
P
E
I
---
L
KCSMDE
T
------
H
P
G
-
Y
-
G
K
E
-------
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
---
H
---
R
-
R
Q
I
L
M
L
R
M
-
I
M
E
G
---------
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
60.33
33%
-145
- C3 -
-
5MAH
2
MELK_HUMAN
A:
[11-264]
-------------
Y
Y
E
L
H
---
E
T
-
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
---
T
L
-------
G
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
--
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
---
A
K
-----------------
S
L
--
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
--
L
-
G
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
-
N
V
M
A
L
Y
K
K
-
I
M
R
G
---------
K
Y
D
V
-
P
K
W
L
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
60.32
36%
-95
- C3 -
-
4BDB
10
CHK2_HUMAN
A:
[7-285]
M
S
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
-----------------
L
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
-
E
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
60.20
36%
-83
- C3 -
-
4A9R
2
CHK2_HUMAN
A:
[8-285]
-
S
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
---------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
60.16
36%
-85
- C3 -
-
4BDI
8
CHK2_HUMAN
A:
[7-285]
M
S
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
----------------
A
L
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
60.02
36%
-87
- C3 -
-
4BDK
4
CHK2_HUMAN
A:
[9-285]
--
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
----------------
A
L
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
589
HHSearch
59.96
37%
-4
- C3 -
-
2Y7J
1
PHKG2_HUMAN
A:
[92-364]
----------
F
Y
Q
K
Y
D
P
K
---
D
V
-
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
--
M
E
V
T
---
A
E
R
L
SP
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
-
H
-
P
H
I
I
T
L
I
D
S
Y
E
S
----
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
-
Y
L
T
E
K
--
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
----
M
Q
I
R
L
S
D
F
G
F
S
---
C
H
L
E
P
G
E
-
K
-
L
R
E
L
C
---
G
T
P
--
G
Y
L
A
P
E
I
---
L
------
K
CSMDET
H
P
G
-
Y
-
G
K
E
-------
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
---
H
---
R
-
R
Q
I
L
M
L
R
M
-
I
M
E
G
---------
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
59.93
48%
-33
- C3 -
-
3LM0
2
ST17B_HUMAN
A:
[34-292]
-----------------
S
---
K
E
-
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
--
L
K
K
R
---
R
------
R
G
Q
D
C
R
A
E
I
L
H
E
I
A
V
L
E
L
A
-
K
-
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
----
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
-
L
C
L
P
E
LA
E
M
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
-
L
L
S
S
I
Y
P
L
G
D
I
K
I
V
D
F
G
M
S
---
R
K
-----------
I
M
---
G
T
P
--
E
Y
L
A
P
E
I
---
L
------
N
------
Y
D
P
-
I
-
T
T
A
-------
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
---
G
---
E
-
D
N
Q
E
T
Y
L
N
-
I
S
Q
V
---------
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
59.90
37%
-80
- C3 -
-
3HZT
9
?
A:
[3-295]
-----------
S
D
R
Y
Q
R
V
---
K
K
-
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
--
I
K
K
S
---
S
V
T
T
--
T
S
N
S
G
A
---
L
L
D
E
V
A
V
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
----
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
-
E
I
I
L
R
--
Q
K
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
R
D
A
L
I
K
I
V
D
F
G
L
S
---
A
H
F
E
V
-------------
G
T
A
--
Y
Y
I
A
P
E
V
---
L
RK----
K
------
Y
D
E
-----
K
-------
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
---
G
---
Q
-
T
D
Q
E
I
L
K
R
-
V
E
K
G
---------
K
F
S
F
D
P
P
D
W
T
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
A
E
E
A
L
N
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
209
Blastp_CBE
59.88
37%
-6
- C3 -
-
2Y7J
1
PHKG2_HUMAN
C:
[96-364]
--------------
Y
D
P
K
---
D
V
-
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
ME
V
T
A
E
---
R
L
S
P
--
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
-
A
G
H
-
P
H
I
I
T
L
I
D
S
Y
E
S
----
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
-
Y
L
T
E
K
--
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
----
N
M
Q
I
R
L
S
D
F
G
F
S
---
C
H
L
E
P
G
E
-
K
-
L
R
E
L
C
---
G
T
P
--
G
Y
L
A
P
E
I
---
L
KCSMDE
T
------
H
P
G
-
Y
-
G
K
E
-------
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
---
H
---
R
-
R
Q
I
L
M
L
R
M
-
I
M
E
G
---------
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
59.83
37%
-4
- C3 -
-
2Y7J
1
PHKG2_HUMAN
A:
[96-364]
--------------
Y
D
P
K
---
D
V
-
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
ME
V
T
A
E
---
R
L
S
P
--
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
-
A
G
H
-
P
H
I
I
T
L
I
D
S
Y
E
S
----
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
-
Y
L
T
E
K
--
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
----
N
M
Q
I
R
L
S
D
F
G
F
S
---
C
H
L
E
P
G
E
-
K
-
L
R
E
L
C
---
G
T
P
--
G
Y
L
A
P
E
I
---
L
KCSMDE
T
------
H
P
G
-
Y
-
G
K
E
-------
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
---
H
---
R
-
R
Q
I
L
M
L
R
M
-
I
M
E
G
---------
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
59.79
36%
-87
- C3 -
-
4A9S
1
CHK2_HUMAN
A:
[9-285]
--
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
---------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
--
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
269
Blastp_CBE
59.74
36%
-87
- C3 -
-
2WTJ
5
CHK2_HUMAN
A:
[7-285]
M
S
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
---------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
-
E
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
59.73
33%
-111
- C3 -
-
5IH9
1
MELK_HUMAN
A:
[9-262]
-------------
Y
Y
E
L
H
---
E
T
-
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
---
T
L
-----------
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
--
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
---
A
K
-----------------
S
L
--
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
S
Y
L
-
G
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
-
N
V
M
A
L
Y
K
K
-
I
M
R
G
---------
K
Y
D
V
-
P
K
W
L
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
59.70
36%
-87
- C3 -
-
2YIR
1
CHK2_HUMAN
A:
[2-279]
-
S
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
-----------------
L
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
59.69
36%
-81
- C3 -
-
2YCF
1
CHK2_HUMAN
A:
[2-279]
-
S
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
59.67
36%
-83
- C3 -
-
2XM9
1
CHK2_HUMAN
A:
[9-285]
--
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
---------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
59.62
33%
-146
- C3 -
-
5M5A
1
MELK_HUMAN
A:
[11-264]
-------------
Y
Y
E
L
H
---
E
T
-
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
---
T
L
-------
G
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
--
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
---
A
------------------
S
L
--
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
--
L
-
G
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
-
N
V
M
A
L
Y
K
K
-
I
M
R
G
---------
K
Y
D
V
-
P
K
W
L
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
59.62
36%
-95
- C3 -
-
4BDD
4
CHK2_HUMAN
A:
[7-285]
M
S
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
--
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
372
Blastp_CBE
59.56
33%
-155
- C3 -
-
5TX3
2
MELK_HUMAN
A:
[14-267]
-------------
Y
Y
E
L
H
---
E
T
-
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
------------------
I
K
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
--
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
----------------------
G
S
L
--
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
----
G
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
-
N
V
M
A
L
Y
K
K
-
I
M
R
G
---------
K
Y
D
V
-
P
K
W
L
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
Blastp_CBE
59.55
41%
5
- C3 -
-
2X4F
4
MYLK4_HUMAN
A:
[79-358]
--
T
A
K
Q
--
G
A
V
N
S
F
Y
T
V
S
KT-
E
I
-
L
-----
G
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
--
I
K
T
R
---
G
M
K
D
--------
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
-
D
-
H
-
A
N
L
I
Q
L
Y
D
A
F
E
S
----
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
--
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
A
K
--
Q
I
K
I
I
D
F
G
L
A
---
R
R
Y
K
P
R
E
-
K
-
L
K
V
N
F
---
G
T
P
--
E
F
L
A
P
E
V
---
V
------
N
------
Y
D
F
-
V
-
S
F
P
-------
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
---
G
---
D
-
N
D
A
E
T
L
N
N
-
I
L
A
C
---------
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
------
S
DHKLHSRL
S
-------
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
59.42
36%
-94
- C3 -
-
4BDA
8
CHK2_HUMAN
A:
[7-285]
M
S
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
-
E
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
59.38
38%
-74
- C3 -
-
3IGO
8
?
A:
[24-296]
--------------
Y
N
I
V
---
C
M
-
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
-------
A
--
S
A
K
N
K
-
T
S
T
I
L
R
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
-
E
I
I
K
R
--
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
---
T
C
F
Q
Q
N
T
------------
T
A
--
Y
Y
I
A
P
E
V
---
L
RG----
T
------
Y
D
E
-----
K
-------
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
---
G
---
K
-
N
E
Y
D
I
L
K
R
-
V
E
T
G
---------
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
59.35
36%
-86
- C3 -
-
2WTD
4
CHK2_HUMAN
A:
[8-285]
-
S
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
---------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
--
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
268
Blastp_CBE
59.30
36%
-82
- C3 -
-
2XBJ
1
CHK2_HUMAN
A:
[9-285]
--
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
----------------
A
L
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
--
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
59.29
36%
-91
- C3 -
-
4BDG
2
CHK2_HUMAN
A:
[7-285]
M
S
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
59.28
35%
-79
- C3 -
-
4CZU
3
CIPKN_ARATH
C:
[13-274]
--------------
Y
E
L
G
---
R
T
-
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
--
I
D
K
E
---
K
V
L
K
--
N
K
M
---
I
A
Q
I
K
R
E
I
S
T
M
K
L
I
-
K
-
H
-
P
N
V
I
R
M
F
E
V
M
A
S
----
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
-
K
I
S
S
N
--
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
-
L
L
L
D
---
A
N
G
A
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
D
G
-
L
-
L
H
D
T
C
---
G
T
P
--
N
Y
V
A
P
E
V
---
I
------
N
------
N
K
G
-
Y
D
G
A
K
-------
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
---
D
---
S
-
N
L
T
S
L
Y
K
K
-
I
F
K
A
---------
E
F
T
C
-
P
P
W
F
S
A
S
---
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
59.28
36%
-83
- C3 -
-
4A9U
10
CHK2_HUMAN
A:
[7-285]
M
S
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
--------------
D
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
--
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
59.25
39%
19
- C3 -
-
2PHK
2
PHKG1_RABIT
A:
[4-275]
------------
E
N
Y
E
P
K
---
E
I
-
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
--
I
D
V
T
GGG
S
F
S
A
--
E
E
V
Q
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
-
S
G
H
-
P
N
I
I
Q
L
K
D
T
Y
E
T
----
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
-
Y
L
T
E
K
--
V
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
----
D
M
N
I
K
L
T
D
F
G
F
S
---
C
Q
L
D
P
G
E
-
K
-
L
R
E
V
C
---
G
T
P
--
S
Y
L
A
P
E
I
---
I
ECSMND
N
------
H
P
G
-
Y
-
G
K
E
-------
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
---
H
---
R
-
K
Q
M
L
M
L
R
M
-
I
M
S
G
---------
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
59.22
36%
-93
- C3 -
-
4BDE
5
CHK2_HUMAN
A:
[7-285]
M
S
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
----------------
A
L
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
--
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
59.13
36%
-89
- C3 -
-
4BDF
3
CHK2_HUMAN
A:
[7-285]
M
S
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
59.13
36%
-90
- C3 -
-
2YCQ
1
CHK2_HUMAN
A:
[3-279]
--
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
59.09
33%
-113
- C3 -
-
5IH8
1
MELK_HUMAN
A:
[9-262]
-------------
Y
Y
E
L
H
---
E
T
-
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
---
T
----------
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
--
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
---
A
K
-----------------
S
L
--
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
S
Y
L
-
G
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
-
N
V
M
A
L
Y
K
K
-
I
M
R
G
---------
K
Y
D
V
-
P
K
W
L
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
59.06
37%
-5
- C3 -
-
2Y7J
1
PHKG2_HUMAN
B:
[96-364]
--------------
Y
D
P
K
---
D
V
-
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
ME
V
T
A
------
S
P
--
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
-
A
G
H
-
P
H
I
I
T
L
I
D
S
Y
E
S
----
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
-
Y
L
T
E
K
--
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
----
N
M
Q
I
R
L
S
D
F
G
F
S
---
C
H
L
E
P
G
E
-
K
-
L
R
E
L
C
---
G
T
P
--
G
Y
L
A
P
E
I
---
L
KCSMDE
T
------
H
P
G
-
Y
-
G
K
E
-------
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
---
H
---
R
-
R
Q
I
L
M
L
R
M
-
I
M
E
G
---------
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
194
Blastp_CBE
59.04
38%
10
- C3 -
-
1PHK
1
PHKG1_RABIT
A:
[17-291]
------------
E
N
Y
E
P
K
---
E
I
-
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
--
I
D
V
T
GGG
S
F
S
A
--
E
E
V
Q
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
-
S
G
H
-
P
N
I
I
Q
L
K
D
T
Y
E
T
----
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
-
Y
L
T
E
K
--
V
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
----
D
M
N
I
K
L
T
D
F
G
F
S
---
C
Q
L
D
P
G
E
-
K
-
L
R
E
V
C
---
G
T
P
--
S
Y
L
A
P
E
I
---
I
ECSMND
N
------
H
P
G
-
Y
-
G
K
E
-------
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
---
H
---
R
-
K
Q
M
L
M
L
R
M
-
I
M
S
G
---------
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
------
Q
--------
Q
-------
Y
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
58.86
41%
11
- C3 -
-
2X4F
3
MYLK4_HUMAN
B:
[79-355]
--
T
A
K
Q
--
G
A
V
N
S
F
Y
T
V
S
KT-
E
I
-
L
G
G
G
--
G
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
--
I
K
T
R
---
G
M
K
D
--------
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
-
D
-
H
-
A
N
L
I
Q
L
Y
D
A
F
E
S
----
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
--
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
A
K
--
Q
I
K
I
I
D
F
G
L
A
---
R
R
Y
K
P
R
E
-
K
-
L
K
V
N
F
---
G
T
P
--
E
F
L
A
P
E
V
---
V
------
N
------
Y
D
F
-
V
-
S
F
P
-------
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
---
G
---
D
-
N
D
A
E
T
L
N
N
-
I
L
A
C
---------
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
------
S
DHKLHSRL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
399
Blastp_CBE
58.84
34%
-84
- C3 -
-
5LXM
6
AURKA_HUMAN
A:
[6-265]
----
R
Q
--
W
A
L
E
D
-
F
E
I
G
---
R
P
-
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
L
E
K
--
A
--
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
--
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
----
E
L
K
I
A
D
F
G
W
S
-----
V
H
A
P
S
-
S
-
R
R
T
L
A
---
G
T
L
--
D
Y
L
P
P
E
M
---
I
------
E
------
G
R
M
-
H
-
D
E
K
-------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
---
A
---
N
-
T
Y
Q
E
T
Y
K
R
-
I
S
R
V
---------
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
------
T
--------
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
270
Blastp_CBE
58.74
36%
-85
- C3 -
-
2WTI
3
CHK2_HUMAN
A:
[8-285]
-
S
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
---------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
-
E
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
58.70
36%
-88
- C3 -
-
4BDC
2
CHK2_HUMAN
A:
[8-285]
-
S
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
-
E
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
58.70
36%
-88
- C3 -
-
2YCR
1
CHK2_HUMAN
A:
[3-279]
--
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
58.56
36%
-89
- C3 -
-
2W0J
1
CHK2_HUMAN
A:
[2-280]
-
S
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
--
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
58.49
36%
-89
- C3 -
-
2YIQ
1
CHK2_HUMAN
A:
[3-279]
--
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
-------------------
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
58.44
36%
-86
- C3 -
-
2YCS
1
CHK2_HUMAN
A:
[2-279]
-
S
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
--
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
58.43
36%
-93
- C3 -
-
4BDH
4
CHK2_HUMAN
A:
[8-285]
-
S
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
58.41
35%
-78
- C3 -
-
4CZU
3
CIPKN_ARATH
A:
[13-274]
--------------
Y
E
L
G
---
R
T
-
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
--
I
D
K
E
---
K
V
L
K
--
N
K
M
---
I
A
Q
I
K
R
E
I
S
T
M
K
L
I
-
K
-
H
-
P
N
V
I
R
M
F
E
V
M
A
S
----
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
-
K
I
S
S
N
--
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
-
L
L
L
D
---
A
N
G
A
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
D
G
-
L
-
L
H
D
T
C
---
G
T
P
--
N
Y
V
A
P
E
V
---
I
------
N
------
N
K
G
-
Y
D
G
A
K
-------
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
---
D
---
S
-
N
L
T
S
L
Y
K
K
-
I
F
K
A
---------
E
F
T
C
-
P
P
W
F
S
A
S
---
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
58.41
36%
-85
- C3 -
-
2W7X
3
CHK2_HUMAN
A:
[2-279]
-
S
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
597
HHSearch
58.37
38%
-109
* C3 *
-
4MVF
2
CDPK2_PLAFK
A:
[54-327]
---------
K
L
E
D
K
Y
I
I
D
---
E
K
-
L
G
Q
G
T
Y
G
C
V
Y
K
G
I
D
K
V
T
N
Q
L
Y
A
I
K
E
--
E
K
K
D
---
R
L
K
--------
N
I
N
R
F
F
Q
E
I
E
I
M
K
K
L
-
D
-
H
-
P
N
I
V
K
L
Y
E
T
Y
E
N
----
D
N
Y
I
Y
L
I
M
E
L
C
S
G
R
E
L
F
D
-
S
I
I
E
N
--
G
S
F
T
E
K
N
A
A
T
I
M
K
Q
I
F
S
A
I
F
Y
L
H
S
L
N
I
V
H
R
D
L
K
P
E
N
F
L
F
Q
S
E
N
-
K
D
S
L
L
K
I
I
D
F
G
L
S
---
K
N
L
----------------------------------------------
K
-
Y
-
D
K
K
-------
C
D
I
W
S
S
G
V
I
M
Y
T
L
L
C
G
Y
P
P
F
Y
---------------------------------
C
F
Y
E
N
D
W
G
S
I
S
S
D
A
K
N
L
I
T
K
L
L
T
Y
N
P
N
E
R
C
T
I
E
E
A
L
N
H
P
W
I
------
T
--------
Q
-------
M
T
K
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
58.36
38%
16
- C3 -
-
1QL6
1
PHKG1_RABIT
A:
[17-291]
------------
E
N
Y
E
P
K
---
E
I
-
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
--
I
D
V
T
GGG
S
F
S
A
--
E
E
V
Q
E
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
-
S
G
H
-
P
N
I
I
Q
L
K
D
T
Y
E
T
----
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
-
Y
L
T
E
K
--
V
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
----
D
M
N
I
K
L
T
D
F
G
F
S
---
C
Q
L
D
P
G
E
-
K
-
L
R
S
V
C
---
G
T
P
--
S
Y
L
A
P
E
I
---
I
ECSMND
N
------
H
P
G
-
Y
-
G
K
E
-------
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
---
H
---
R
-
K
Q
M
L
M
L
R
M
-
I
M
S
G
---------
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
------
Q
--------
Q
-------
Y
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
58.24
36%
-93
- C3 -
-
4BDJ
1
CHK2_HUMAN
A:
[9-285]
--
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
-----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
-
E
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
58.19
36%
-73
- C3 -
-
5KZ8
1
MARK2_HUMAN
A:
[34-297]
-------------
N
Y
R
L
L
---
K
T
-
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
--
I
D
K
T
---
Q
L
N
S
--
S
----
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
-
N
-
H
-
P
N
I
V
K
L
F
E
V
I
E
T
----
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
-
Y
L
V
A
H
--
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
-
L
L
L
D
A
D
M
---
N
I
K
I
A
D
F
G
-------------------
C
---
G
S
P
--
P
Y
A
A
P
E
L
---
F
------
Q
------
G
K
K
-
Y
D
G
P
E
-------
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
---
G
---
Q
-
N
L
K
E
L
R
E
R
-
V
L
R
G
---------
K
Y
R
I
-
P
F
Y
M
S
T
D
C
E
---
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
---------------------------
N
--
V
G
H
E
D
D
E
L
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
58.05
33%
-116
- C3 -
-
5IHA
1
MELK_HUMAN
A:
[9-262]
-------------
Y
Y
E
L
H
---
E
T
-
I
G
----
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
---
T
L
------------
R
I
K
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
--
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
---
A
K
-----------------
S
L
--
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
S
Y
L
-
G
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
-
N
V
M
A
L
Y
K
K
-
I
M
R
G
---------
K
Y
D
V
-
P
K
W
L
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
57.94
38%
-81
- C3 -
-
6BAB
1
KCC2D_MOUSE
D:
[10-273]
---------
R
F
-
D
E
Y
Q
L
F
---
E
E
-
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
L
S
A
--
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
---
I
E
V
Q
G
D
Q
-
Q
A
W
F
G
F
A
---
G
T
P
--
G
Y
L
S
P
E
V
---
L
------
R
------
K
D
P
-
Y
-
G
K
P
-------
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
-
D
Q
H
R
L
Y
Q
Q
-
I
K
A
G
---------
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
57.79
36%
-82
- C3 -
-
2WTC
1
CHK2_HUMAN
A:
[9-285]
--
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
---------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
--
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
57.70
48%
-8
- C3 -
-
3LM5
1
ST17B_HUMAN
A:
[34-292]
-----------------
S
---
K
E
-
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
--
L
K
K
R
---
R
------
R
G
Q
D
C
R
A
E
I
L
H
E
I
A
V
L
E
L
A
-
K
-
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
----
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
-
L
C
L
P
E
L-
E
M
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
-
L
L
S
S
I
Y
P
L
G
D
I
K
I
V
D
F
G
M
S
---
R
K
-----------
I
M
---
G
T
P
--
E
Y
L
A
P
E
I
---
L
------
N
------
Y
D
P
-
I
-
T
T
A
-------
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
---
G
---
E
-
D
N
Q
E
T
Y
L
N
-
I
S
Q
V
---------
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
57.61
35%
-91
- C3 -
-
6B2E
2
AAPK2_HUMAN
A:
[28-382]
-------------
H
Y
V
L
G
---
D
T
-
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
---
K
I
R
S
--
L
D
---
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
----
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
H
--
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
D
A
H
M
---
N
A
K
I
A
D
F
G
L
S
---
N
M
M
S
D
G
--
E
-
F
L
R
S
C
---
G
S
P
--
N
Y
A
A
P
E
V
---
I
------
S
GRL---
Y
A
----
G
P
E
-------
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
---
D
---
E
-
H
V
P
T
L
F
K
K
-
I
R
G
G
---------
V
F
-
Y
I
P
E
Y
L
N
R
S
---
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
57.59
36%
-88
- C3 -
-
2CN8
1
CHK2_HUMAN
A:
[10-285]
---
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
--
T
S
-
L
-
M
R
T
L
C
-----
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
----
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
57.51
33%
-152
- C3 -
-
5TX3
2
MELK_HUMAN
B:
[14-267]
-------------
Y
Y
E
L
H
---
E
T
-
I
G
-----
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
--------------------
K
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
--
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
-------------------------
G
S
L
--
A
Y
A
A
P
E
L
---
I
------
Q
------
G
---
L
-
G
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
-
N
V
M
A
L
Y
K
K
-
I
M
R
G
---------
K
Y
D
V
-
P
K
W
L
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
57.09
38%
-99
- C3 -
-
4MVF
2
CDPK2_PLAFK
A:
[55-326]
----------
L
E
D
K
Y
I
I
D
---
E
K
-
L
G
Q
G
T
Y
G
C
V
Y
K
G
I
D
K
V
T
N
Q
L
Y
A
I
K
E
--
E
K
K
D
---
R
L
K
N
--
I
N
R
------
F
F
Q
E
I
E
I
M
K
K
L
-
D
-
H
-
P
N
I
V
K
L
Y
E
T
Y
E
N
----
D
N
Y
I
Y
L
I
M
E
L
C
S
G
R
E
L
F
D
-
S
I
I
E
N
--
G
S
F
T
E
K
N
A
A
T
I
M
K
Q
I
F
S
A
I
F
Y
L
H
S
L
N
I
V
H
R
D
L
K
P
E
N
F
L
F
Q
S
E
N
-
K
D
S
L
L
K
I
I
D
F
G
L
S
---
K
N
L
--------------------------------------K-----
Y
D
K
-----
K
-------
C
D
I
W
S
S
G
V
I
M
Y
T
L
L
C
G
Y
P
P
F
Y
---------------------------------
C
F
Y
E
N
D
W
G
S
I
S
S
D
A
K
N
L
I
T
K
L
L
T
Y
N
P
N
E
R
C
T
I
E
E
A
L
N
H
P
W
I
------
T
--------
Q
-------
M
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
56.82
36%
-64
- C3 -
-
5EAK
1
MARK2_HUMAN
A:
[16-279]
-------------
N
Y
R
L
L
---
K
T
-
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
--
I
D
K
T
---
Q
L
N
S
--
S
----
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
-
N
-
H
-
P
N
I
V
K
L
F
E
V
I
E
T
----
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
-
Y
L
V
A
H
--
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
-
L
L
L
D
A
D
M
---
N
I
K
I
A
D
F
G
F
S
----------------
F
C
---
G
S
P
--
P
Y
A
A
P
E
L
---
F
------
Q
------
G
K
K
-
Y
D
G
P
E
-------
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
---
G
---
Q
-
N
L
K
E
L
R
E
R
-
V
L
R
G
---------
K
Y
R
I
-
P
F
Y
M
S
T
D
C
E
---
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
---------------------------
N
--
V
G
H
E
D
D
E
L
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
231
Blastp_CBE
56.68
35%
-73
- C3 -
-
2WNT
2
B:
[26-286]
-----------
S
D
G
Y
V
V
K
---
E
T
-
I
G
V
G
S
Y
S
E
C
K
R
C
V
H
K
A
T
N
M
E
Y
A
V
K
V
--
I
D
K
S
---
K
R
D
P
--
S
------
E
E
I
E
I
---
L
L
R
Y
G
-
Q
-
H
-
P
N
I
I
T
L
K
D
V
Y
D
D
----
G
K
H
V
Y
L
V
T
E
L
M
R
G
G
E
L
L
D
-
K
I
L
R
Q
--
K
F
F
S
E
R
E
A
S
F
V
L
H
T
I
G
K
T
V
E
Y
L
H
S
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
G
N
P
E
C
L
R
I
C
D
F
G
F
A
---
K
Q
L
R
A
E
N
-----
G
L
L
---
M
T
P
CY-----------------
K
------
R
Q
G
-
Y
-
D
E
G
-------
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
A
G
Y
T
P
F
A
NGP
S
---
D
-
T
P
E
E
I
L
T
R
-
I
G
S
G
---------
K
F
T
L
S
G
G
N
W
N
T
V
S
E
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
K
Q
V
L
Q
H
P
W
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
56.67
33%
-118
- C3 -
-
5IHC
1
MELK_HUMAN
A:
[9-262]
-------------
Y
Y
E
L
H
---
E
T
-
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
---
T
L
-------
G
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
--
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
------------------------
G
S
L
--
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
S
Y
L
-
G
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
-
N
V
M
A
L
Y
K
K
-
I
M
R
G
---------
K
Y
D
V
-
P
K
W
L
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
285
Blastp_CBE
56.62
36%
-70
- C3 -
-
5EAK
1
MARK2_HUMAN
B:
[16-279]
-------------
N
Y
R
L
L
---
K
T
-
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
--
I
D
K
T
---
Q
L
N
S
--
S
----
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
-
N
-
H
-
P
N
I
V
K
L
F
E
V
I
E
T
----
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
-
Y
L
V
A
H
--
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
-
L
L
L
D
A
D
M
---
N
I
K
I
A
D
F
G
------------------
F
C
---
G
S
P
--
P
Y
A
A
P
E
L
---
F
------
Q
------
G
K
K
-
Y
D
G
P
E
-------
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
---
G
---
Q
-
N
L
K
E
L
R
E
R
-
V
L
R
G
---------
K
Y
R
I
-
P
F
Y
M
S
T
D
C
E
---
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
---------------------------
N
--
V
G
H
E
D
D
E
L
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
291
Blastp_CBE
56.58
36%
-74
- C3 -
-
5KZ8
1
MARK2_HUMAN
B:
[34-297]
-------------
N
Y
R
L
L
---
K
T
-
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
--
I
D
K
T
---
Q
L
N
S
--
S
----
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
-
N
-
H
-
P
N
I
V
K
L
F
E
V
I
E
T
----
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
-
Y
L
V
A
H
--
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
-
L
L
L
D
A
D
M
---
N
I
K
I
A
D
F
------------------------
G
S
P
--
P
Y
A
A
P
E
L
---
F
------
Q
------
G
K
K
-
Y
D
G
P
E
-------
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
---
G
---
Q
-
N
L
K
E
L
R
E
R
-
V
L
R
G
---------
K
Y
R
I
-
P
F
Y
M
S
T
D
C
E
---
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
---------------------------
N
--
V
G
H
E
D
D
E
L
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
56.34
36%
-82
- C3 -
-
2XK9
1
CHK2_HUMAN
A:
[9-278]
------------
D
E
Y
I
M
S
---
K
T
-
L
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
------------------
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
T
S
-
L
-
M
R
T
L
C
---
G
T
P
--
T
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
56.27
36%
-98
- C3 -
-
2XM8
1
CHK2_HUMAN
A:
[9-285]
--
V
Y
P
K
--
A
-
L
R
D
E
Y
I
M
S
---
K
T
-
L
-----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-----------------------
N
V
E
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
----
E
-
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
--
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
---
K
I
L
--
T
S
-
L
-
M
R
T
L
C
---
G
-----
Y
L
A
P
E
V
LVS
V
------
G
------
T
A
G
-
Y
-
N
R
A
-------
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
---
H
-
R
T
Q
V
S
L
K
D
Q
I
T
S
G
---------
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
376
Blastp_CBE
55.60
33%
-116
- C3 -
-
5MAI
2
MELK_HUMAN
A:
[11-266]
-------------
Y
Y
E
L
H
---
E
T
-
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
---
T
L
-------
G
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
--
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
-------------------------
S
L
--
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
S
Y
L
-
G
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
-
N
V
M
A
L
Y
K
K
-
I
M
R
G
---------
K
Y
D
V
-
P
K
W
L
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
55.40
33%
-110
- C3 -
-
5K00
1
MELK_HUMAN
A:
[9-262]
-------------
Y
Y
E
L
H
---
E
T
-
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
---
T
L
-------
G
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
--
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
----
K
L
K
L
I
D
F
G
L
C
---
A
K
P
----------------
S
L
--
A
Y
A
A
P
E
L
---
I
------
Q
------
G
K
S
Y
L
-
G
S
E
-------
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
-
N
V
M
A
L
Y
K
K
-
I
M
R
G
---------
K
Y
D
V
-
P
K
W
L
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
54.79
36%
-77
- C3 -
-
5KZ7
1
MARK2_HUMAN
A:
[34-297]
-------------
N
Y
R
L
L
---
K
T
-
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
--
I
D
K
T
---
Q
L
N
S
--
S
----
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
-
N
-
H
-
P
N
I
V
K
L
F
E
V
I
E
T
----
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
-
Y
L
V
A
H
--
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
-
L
L
L
D
A
D
M
---
N
I
K
I
A
D
F
------------------------
G
S
P
--
P
Y
A
A
P
E
L
---
F
------
Q
------
G
K
---D
G
P
E
-------
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
---------
N
L
K
E
L
R
E
R
-
V
L
R
G
---------
K
Y
R
I
-
P
F
Y
M
S
T
D
C
E
---
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
---------------------------
N
--
V
G
H
E
D
D
E
L
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
54.73
36%
-74
- C3 -
-
5KZ7
1
MARK2_HUMAN
B:
[34-297]
-------------
N
Y
R
L
L
---
K
T
-
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
--
I
D
K
T
---
Q
L
N
S
--
S
----
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
-
N
-
H
-
P
N
I
V
K
L
F
E
V
I
E
T
----
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
-
Y
L
V
A
H
--
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
-
L
L
L
D
A
D
M
---
N
I
K
I
A
D
F
------------------------
G
S
P
--
P
Y
A
A
P
E
L
---
F
------
Q
------
G
K
---D
G
P
E
-------
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
---------
N
L
K
E
L
R
E
R
-
V
L
R
G
---------
K
Y
R
I
-
P
F
Y
M
S
T
D
C
E
---
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
---------------------------
N
--
V
G
H
E
D
D
E
L
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
Blastp_CBE
54.26
41%
20
- C3 -
-
6T6F
1
?
A:
[5-287]
---
W
K
K
QA
E
D
I
K
K
I
F
E
F
K
---
E
T
-
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
--
I
P
K
K
---
A
L
K
G
--
K
E
S
S
-----
I
E
N
E
I
A
V
L
R
K
I
-
K
-
H
-
E
N
I
V
A
L
E
D
I
Y
E
S
----
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
V
E
K
--
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
Q
D
-
E
E
S
K
I
M
I
S
D
F
G
L
S
-----------------------
P
--
G
Y
V
A
P
E
V
---
L
------
A
------
Q
K
P
-
Y
-
S
K
A
-------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
---
E
-
N
D
S
K
L
F
E
Q
-
I
L
K
A
---------
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
281
Blastp_CBE
54.08
35%
-79
- C3 -
-
5XZV
1
?
B:
[195-466]
-----------
K
D
F
S
I
I
D
---
E
V
-
V
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
A
V
K
I
--
I
S
K
R
---
K
------
M
D
G
V
T
R
E
-----
L
E
V
L
Q
K
L
-
N
-
H
-
P
R
I
V
R
L
K
G
F
Y
E
D
----
T
E
S
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
-
F
V
A
A
H
--
G
A
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
-
L
I
E
Q
D
D
P
-
V
L
V
K
I
T
D
F
G
L
----------------
T
F
C
---
G
T
L
--
A
Y
V
A
P
E
V
---
I
----------------------RNEYSSL
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
S
---
G
---
S
-
T
Q
D
Q
L
Y
K
Q
-
I
G
R
G
---------
S
Y
H
E
G
P
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
R
S
T
A
A
K
A
L
N
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
Blastp_CBE
53.42
41%
23
- C3 -
-
6T6F
1
?
B:
[5-287]
---
W
K
K
QA
E
D
I
K
K
I
F
E
F
K
---
E
T
-
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
--
I
P
K
K
---
A
L
K
G
--
K
E
S
S
-----
I
E
N
E
I
A
V
L
R
K
I
-
K
-
H
-
E
N
I
V
A
L
E
D
I
Y
E
S
----
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
V
E
K
--
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
Q
D
-
E
E
S
K
I
M
I
S
D
F
G
-------------------------
P
--
G
Y
V
A
P
E
V
---
L
------
A
------
Q
K
P
-
Y
-
S
K
A
-------
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
---
E
-
N
D
S
K
L
F
E
Q
-
I
L
K
A
---------
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
51.70
35%
-98
- C3 -
-
5XZV
1
RAD53_YEAST
A:
[195-465]
-----------
K
D
F
S
I
I
D
---
E
V
-
V
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
A
V
K
I
--
I
S
K
R
---
K
V
I
G
--
N
M
D
G
V
T
R
E
-----
L
E
V
L
Q
K
L
-
N
-
H
-
P
R
I
V
R
L
K
G
F
Y
E
D
----
T
E
S
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
-
F
V
A
A
H
--
G
A
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
-
L
I
E
Q
D
D
P
-
V
L
V
K
I
T
D
F
G
L
A
---
K
-------------------
L
--
A
Y
V
A
P
E
V
---
I
----------------------NEYSSL-
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
--------
S
-
T
Q
D
Q
L
Y
K
Q
-
I
G
R
G
---------
S
-----
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
---
D
P
N
N
--
T
A
A
K
A
L
N
H
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
518
Blastp_CBE
41.19
36%
12
- C3 -
-
3FXW
1
MAPK3_HUMAN
A:
[26-291]
----------
V
T
D
D
Y
Q
L
S
---
K
Q
V
L
G
L
G
V
-
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
----------
L
Y
D
--
S
P
K
--
A
R
Q
E
V
D
H
H
---
W
Q
A
S
-
G
-
G
-
P
H
I
V
C
I
L
D
V
Y
E
N
MHHG
K
R
C
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
-
R
I
Q
E
R
D-
Q
A
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
-
K
D
A
V
L
K
L
T
D
F
G
F
A
----
K
E
---------------------------------------------
E
K
-
Y
-
D
K
S
-------
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
----------------------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
I
T
Q
F
M
N
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
41.05
34%
22
- C3 -
-
3KN5
1
KS6A5_HUMAN
A:
[9-275]
-------------
H
Y
D
L
D
LKD
K
P
-
L
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
--
I
S
K
R
---
M
E
A
N
--
T
---------
Q
K
E
I
T
A
L
K
L
C
-
E
G
H
-
P
N
I
V
K
L
H
E
V
F
H
D
----
Q
L
H
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
-
R
I
K
K
K
--
K
H
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
-----
L
E
I
K
I
I
D
F
G
F
A
---
R
L
K
P
P
-------------------------------------------
N
G
-
Y
-
D
E
S
-------
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
--------
Q
--------
C
-
T
S
A
V
EIMKKIKKG
D
F
S
F
E
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
M
S
G
L
R
Y
N
E
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
283
Blastp_CBE
39.02
34%
27
- C3 -
-
3KN5
1
B:
[9-275]
-------------
H
Y
D
L
D
LKD
K
P
-
L
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
--
I
S
K
R
---
M
E
A
N
--
T
---------
Q
K
E
I
T
A
L
K
L
C
-
E
G
H
-
P
N
I
V
K
L
H
E
V
F
H
D
----
Q
L
H
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
-
R
I
K
K
K
--
K
H
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
-----
L
E
I
K
I
I
D
F
G
F
A
---
R
L
K
P
P
-------------------------------------------
N
G
-
Y
-
D
E
S
-------
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
--------
Q
-
S
H
D
R
S
L
T
C
-
T
S
A
V
EIMKKIKKG
D
F
S
F
E
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
M
S
G
L
R
Y
N
E
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------