@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DCLK2_HUMAN: (2020-09-07 )
MASTRSIELEHFEERDKRPRPGSRRGAPSSSGGSSSSGPKGNGLIPSPAHSAHCSFYRTRTLQALSSEKKAKKARFYRNGDRYFKGLVFAISSDRFRSFDALLIELTRSLSDNVNLPQGVRTIYTIDGSRKVTSLDELLEGESYVCASNEPFRKVDYTKNINPNWSVNIKGGTSRALAAASSVKSEVKESKDFIKPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTLDGKQVTCLQDFFGDDDVFIACGPEKFRYAQDDFVLDHSECRVLKSSYSRSSAVKYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKQISAHGRSSSNVNGGPELDRCISPEGVNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTALDKEGQIFCSKHCQDSGRPGMEPISPVPPSVEEIPVPGEAVPAPTPPESPTPHPPPAAPGGERAGTWRRHRD
Atome Classification :
(247 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.-...-...400.......410.......420....--...-------430-----.----..--.-----.----.----..------.440.....-.-.-450.......460..----.....470.....-..480.--..----.---...490.......500.......510.......520.-.......530.......540-.--.-----.--.---.---.---..550.........560.------.------..---.-----.-.570.......580.......590-----..-..--..--..600.......610......-.620.......630.......640.......650------------........660.......670---........680.......690.......700.......710.......720.......730.......740.......750.......760....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAST
R
S
I
E
L
E
H
F
E
E
RDKRPRPGSRRGAPSSSGGSSSSGPKGNGLIPSPAHS
A
H
C
S
F
Y
R
T
R
T
L
Q
A
L
S
S
E
K
K
A
K
K
A
R
FYRN
G
D
R
Y
F
K
G
L
V
F
A
ISSDRF
R
S
F
D
A
L
L
I
E
L
T
R
S
LSDNVNLPQG
V
R
T
I
Y
T
IDGSRKV
T
S
L
D
E
L
LEGE
S
Y
V
CASNEP
F
R
KVDYTKNINPN
W
S
V
N
IKGGT
S
R
A
L
A
A
A
S
S
V
K
S
E
V
K
E
S
K
DFI
K
P
K
L
V
T
V
I
R
SGV
K
P
R
K
A
V
R
I
L
LNKK
T
A
H
S
F
E
Q
V
L
T
D
I
T
E
A
I
KL
D
S
G
V
V
K
R
L
C
TLDG
K
Q
V
T
C
L
Q
D
FFGDD
D
V
F
I
A
CG
P
E
KFRYAQD
D
F
V
L
D
H
S
E
C
R
V
L
K
S
SYSRS
S
A
V
KYSGSKSPGPSRRSKSPASVNGTPSSQLSTPKSTKSSSSSPTSPG
S
F
R
G
L
K
Q
I
S
AHGRSSSNVNGGPE
L
D
RCISPEGVNGNRCS
E
S
S
T
L
L
E
K
-YKI-
G
K
V
IGDG
N
F
A
V
V
K
E
C
I
D
RST
G
K
E
F
A
L
K
I
I
D
--
K
A
K
-------C-------C----
G
K
--
E
-----
H
----
L
----
I
E
------
N
E
V
S
I
L
R
R
V-K-H-P
N
I
I
M
L
V
E
E
M
E
T
A
T
E
----
L
F
L
V
M
E
L
VKGG
D
L
-
F
D
A
I
TS--ST----K---YTERDG
S
A
M
V
Y
N
L
A
N
A
L
R
Y
L
H
G
L
S
I
V
H
RDIKPE
N
-
L
L
-
V
C
EYPDGTKSLKLGDF
G
L
A
--
T
--V-----V--E---G---P---
L
Y
T
--VCGTPTY
V
A
P
E
I
I
------A------ET---G-----Y-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
LCGFPPF------RS-EN--
N
L
--
Q
E
D
L
F
D
Q
I
L
AGKLEFPAPYWD-NI
T
D
S
A
K
E
L
I
S
Q
M
L
QVN
V
E
A
R
CTAGQILSHPWV-------------SDDASQENNM
Q
A
E
V
T
G
K
L
K
Q
----
H
F
N
N
ALPKQNSTT
T
G
V
S
V
I
M
N
TALDKEG
Q
I
F
C
S
KHCQDSGRPGMEPISPVPP
S
V
E
EIPVPGEAVPAPTPPESPTPHPPPAAPGGERAGTWRRHRD
2
PsiBlast_PDB
85.51
75%
-130
- C1 -
-
5JZN
1
DCLK1_HUMAN
A:
[15-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
E
R
-
Y
K
V
-
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
--
K
S
K
-------
C
-------
R
----
G
K
--
E
-----
H
----
M
----
I
Q
------
N
E
V
S
I
L
R
R
V
-
K
-
H
-
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
----
L
Y
L
V
M
E
L
V
K
G
G
D
L
-
F
D
A
I
T
S
--
T
N
----
K
---
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
-
L
L
-
V
Y
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
--
T
--
I
-----
V
--
D
---
G
---
P
---
L
Y
T
--
V
C
G
T
P
T
Y
V
A
P
E
I
I
------
A
------
E
T
---
G
-----
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
------
R
G
-
S
----
D
--
Q
E
V
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
-
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
V
Q
V
L
E
H
P
W
V
-------------
N
----------------------------------------------------------------------------------------------------------------------
575
HHSearch
85.49
76%
-130
- C1 -
-
5JZN
1
DCLK1_HUMAN
A:
[16-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
T
E
R
-
Y
K
V
-
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
--
K
S
K
-------
C
-------
R
----
G
K
--
E
-----
H
----
M
----
I
Q
------
N
E
V
S
I
L
R
R
V
-
K
-
H
-
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
----
L
Y
L
V
M
E
L
V
K
G
G
D
L
-
F
D
A
I
T
S
--
T
N
----
K
---
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
-
L
L
-
V
Y
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
--
T
--
I
-----
V
--
D
---
G
---
P
---
L
Y
T
--
V
C
G
T
P
T
Y
V
A
P
E
I
I
------
A
------
E
T
---
G
-----
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
------
R
G
-
S
----
D
--
Q
E
V
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
-
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
V
Q
V
L
E
H
P
W
V
-------------
N
----------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
85.45
76%
-129
- C1 -
-
5JZN
1
B:
[15-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
E
R
-
Y
K
V
-
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
--
K
S
K
-------
C
-------
R
----
G
K
--
E
-----
H
----
M
----
I
Q
------
N
E
V
S
I
L
R
R
V
-
K
-
H
-
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
----
L
Y
L
V
M
E
L
V
K
G
G
D
L
-
F
D
A
I
T
S
--
T
N
----
K
---
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
-
L
L
-
V
Y
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
--
T
--
I
-----
V
--
D
---
G
---
P
---
L
Y
T
--
V
C
G
T
P
T
Y
V
A
P
E
I
I
------
A
------
E
T
---
G
-----
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
------
R
G
-
S
-------
Q
E
V
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
-
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
V
Q
V
L
E
H
P
W
V
-------------
N
----------------------------------------------------------------------------------------------------------------------
580
HHSearch
85.00
76%
-133
- C1 -
-
5JZJ
1
B:
[32-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
E
R
-
Y
K
V
-
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
--
K
S
K
-------
C
-------
R
----
G
K
--
E
-----
H
----
M
----
I
Q
------
N
E
V
S
I
L
R
R
V
-
K
-
H
-
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
----
L
Y
L
V
M
E
L
V
K
G
G
D
L
-
F
D
A
I
T
S
--
T
N
----
K
---
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
-
L
L
-
V
Y
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
--
T
--
I
-----
V
--
D
---
G
---
P
---
L
Y
T
--
V
C
G
T
P
T
Y
V
A
P
E
I
I
------
A
------
E
T
---
G
-----
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
------
R
-----------
E
V
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
-
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
V
Q
V
L
E
H
P
W
V
-------------
N
----------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
85.00
76%
-133
- C1 -
-
5JZJ
1
B:
[32-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
E
R
-
Y
K
V
-
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
--
K
S
K
-------
C
-------
R
----
G
K
--
E
-----
H
----
M
----
I
Q
------
N
E
V
S
I
L
R
R
V
-
K
-
H
-
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
----
L
Y
L
V
M
E
L
V
K
G
G
D
L
-
F
D
A
I
T
S
--
T
N
----
K
---
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
-
L
L
-
V
Y
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
--
T
--
I
-----
V
--
D
---
G
---
P
---
L
Y
T
--
V
C
G
T
P
T
Y
V
A
P
E
I
I
------
A
------
E
T
---
G
-----
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
------
R
-----------
E
V
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
-
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
V
Q
V
L
E
H
P
W
V
-------------
N
----------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
84.20
75%
-134
- C1 -
-
5JZJ
2
DCLK1_HUMAN
A:
[32-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
T
E
R
-
Y
K
V
-
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
--
K
S
K
-------
C
-------
R
----
G
K
--
E
-----
H
----
M
----
I
Q
------
N
E
V
S
I
L
R
R
V
-
K
-
H
-
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
----
L
Y
L
V
M
E
L
V
K
G
G
D
L
-
F
D
A
I
T
S
--
T
N
----
K
---
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
-
L
L
-
V
Y
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
L
A
--
T
--
I
-----
V
--
D
---
G
---
P
---
L
Y
T
--
V
C
G
T
P
T
Y
V
A
P
E
I
I
------
A
------
E
T
---
G
-----
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
------
R
G
-
S
--------
E
V
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
-
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
V
Q
V
L
E
H
P
W
V
-------------
N
----------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
78.30
42%
-135
- C1 -
-
6T6F
1
?
A:
[16-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
F
-
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
--
K
K
A
-------
L
-------
K
----
G
K
--
E
-----
S
----
S
----
I
E
------
N
E
I
A
V
L
R
K
I
-
K
-
H
-
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
----
L
Y
L
V
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
E
--
K
G
----
F
---
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
Y
Y
S
Q
D
E
E
S
K
-
I
M
I
S
D
F
G
L
S
-----------------------------------
P
G
Y
V
A
P
E
V
L
------
A
------
Q
K
---
P
-----
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
D
-
E
N
--
D
S
--
K
--
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
-------------
A
G
D
T
A
L
N
K
N
I
H
E
S
V
S
A
Q
I
R
K
----
N
F
A
K
S
K
-
R
Q
A
F
N
A
T
A
V
-------------------------------------------------------------------------------
26
Blastp_CBE
78.07
42%
-134
- C1 -
-
6T6F
1
?
B:
[16-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
F
-
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
--
K
K
A
-------
L
-------
K
----
G
K
--
E
-----
S
----
S
----
I
E
------
N
E
I
A
V
L
R
K
I
-
K
-
H
-
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
----
L
Y
L
V
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
E
--
K
G
----
F
---
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
Y
Y
S
Q
D
E
E
S
K
-
I
M
I
S
D
F
G
-------------------------------------
P
G
Y
V
A
P
E
V
L
------
A
------
Q
K
---
P
-----
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
D
-
E
N
--
D
S
--
K
--
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
-------------
A
G
D
T
A
L
N
K
N
I
H
E
S
V
S
A
Q
I
R
K
----
N
F
A
K
S
K
-
R
Q
A
F
N
A
T
A
V
-------------------------------------------------------------------------------
9
PsiBlast_PDB
74.16
42%
-133
- C1 -
-
2JC6
1
KCC1D_HUMAN
A:
[24-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
F
-
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
--
K
K
A
------------------------------
S
----
S
----
I
E
------
N
E
I
A
V
L
R
K
I
-
K
-
H
-
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
----
L
Y
L
V
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
E
--
K
G
----
F
---
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
Y
Y
S
Q
D
E
E
S
K
-
I
M
I
S
----------------------------------------
P
G
Y
V
A
P
E
V
L
------
A
------
Q
K
---
P
-----
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
D
-
E
N
--
D
S
--
K
--
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
-------------
A
G
D
T
A
L
N
K
N
I
H
E
S
V
S
A
Q
I
R
K
----
N
F
A
K
S
K
W
R
Q
A
F
N
A
T
---------------------------------------------------------------------------------
8
PsiBlast_PDB
74.07
43%
-150
- C1 -
-
4FG7
1
KCC1A_HUMAN
A:
[9-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
W
K
Q
A
E
D
I
R
D
I
-
Y
D
F
-
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
----------------------------------------
S
----
M
E
------
N
E
I
A
V
L
H
K
I
-
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
E
--
K
G
----
F
---
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
G
L
S
--
K
--------
M
--
E
---
D
---
P
----------
G
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
K
-----------
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
D
-
E
N
--
D
A
--
K
--
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
-------------
A
----------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
74.01
42%
-122
- C1 -
-
1A06
-
KCC1A_RAT
A:
[10-312]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
Q
A
E
D
I
R
D
I
-
Y
D
F
-
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
--
K
-------------------------------------------
E
------
N
E
I
A
V
L
H
K
I
-
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
E
--
K
G
----
F
---
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
--------------------------------------
P
G
Y
V
A
P
E
V
L
------
A
------
Q
K
---
P
-----
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
D
-
E
N
--
D
A
--
K
--
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
-------------
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
----
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
-------------------------------------------------------------------------------
13
PsiBlast_PDB
73.55
38%
-34
- C1 -
-
5U6Y
-
KCC2A_RAT
A:
[2-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
L
-
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
K
I
I
N
--
T
K
K
-------
L
-------
S
----
A
R
--
D
-----
H
----
Q
K---
L
E
------
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
----
H
Y
L
I
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
A
--
R
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
-
L
L
-
L
A
S
K
L
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
--
E
-----
V
--
E
---
G
EQQ
A
---
W
F
G
--
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
---
P
-----
Y
-
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
------
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
-------------
S
H
R
S
T
V
A
S
C
M
H
R
Q
E
T
V
D
C
L
K
----
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
A
T
R
N
F
S
G
G
K
S
G
-------------------------------------------------------------------
5
PsiBlast_PDB
73.50
42%
-139
- C1 -
-
4FG8
1
KCC1A_HUMAN
A:
[10-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
Q
A
E
D
I
R
D
I
-
Y
D
F
-
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
--
K
-------------------------------------------
E
------
N
E
I
A
V
L
H
K
I
-
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
E
--
K
G
----
F
---
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
-------------------------------------
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
K
---
P
-----
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
D
-
E
N
--
D
A
--
K
--
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
-------------
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
----
N
F
A
--------------------------------------------------------------------------------------------
6
PsiBlast_PDB
72.04
42%
-124
- C1 -
-
4FG9
1
KCC1A_HUMAN
A:
[10-312]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
Q
A
E
D
I
R
D
I
-
Y
D
F
-
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
--
K
E
------------------------------------------
E
------
N
E
I
A
V
L
H
K
I
-
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
E
--
K
G
----
F
---
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
--------------------------------------
P
G
Y
V
A
P
E
V
L
------
A
------
Q
K
---
P
-----
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
D
-
E
N
--
D
A
--
K
--
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
-------------
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
----
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
-------------------------------------------------------------------------------
30
Blastp_CBE
71.95
39%
-43
- C1 -
-
2VZ6
3
KCC2A_HUMAN
B:
[18-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
F
Q
S
M
-
Y
Q
L
-
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
K
I
I
N
--
T
K
K
-------
L
-------
S
----
A
R
--
D
-----
H
----
Q
K---
L
E
------
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
----
H
Y
L
I
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
A
--
R
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
-
L
L
-
L
A
S
K
L
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
--
E
-----
V
--
E
---
G
EQQ
A
---
W
F
G
--
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
---
P
-----
Y
-
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
------
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
-------------
S
H
R
S
T
V
A
S
C
M
H
R
Q
E
T
V
D
C
L
K
----
K
F
N
--------------------------------------------------------------------------------------------
25
Blastp_CBE
71.90
42%
-132
- C1 -
-
2JC6
1
KCC1D_HUMAN
C:
[24-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
F
-
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
--
K
K
A
-----------------------------------
S
----
I
E
------
N
E
I
A
V
L
R
K
I
-
K
-
H
-
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
----
L
Y
L
V
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
E
--
K
G
----
F
---
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
Y
Y
S
Q
D
E
E
S
K
-
I
M
I
S
----------------------------------------
P
G
Y
V
A
P
E
V
L
------
A
------
Q
K
---
P
-----
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
D
-
E
N
--
D
S
--
K
--
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
-------------
A
G
D
T
A
L
N
K
N
I
H
E
S
V
S
A
Q
I
R
K
----
N
F
A
K
S
K
W
R
Q
A
F
N
A
T
---------------------------------------------------------------------------------
10
PsiBlast_PDB
71.39
38%
-88
- C1 -
-
2JAM
3
KCC1G_HUMAN
A:
[6-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
K
T
-
F
I
F
-
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
--
K
--------------------------------
S
----
S
----
L
E
------
N
E
I
A
V
L
K
K
I
-
K
-
H
-
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
----
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
L
E
--
R
G
----
V
---
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
Y
L
T
-
P
E
E
N
S
K
I
M
I
T
D
F
G
L
S
--
K
--
M
-----
E
--
Q
N--
G
---
I
---
M
S
T
--
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
K
---
P
-----
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
------
Y
E
-
E
T
------
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
-
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
-------------
D
G
N
T
A
L
H
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
----
N
F
A
K
S
------------------------------------------------------------------------------------------
14
PsiBlast_PDB
71.31
39%
-45
- C1 -
-
2VZ6
2
KCC2A_HUMAN
A:
[18-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
F
Q
S
M
-
Y
Q
L
-
F
E
E
L
G
K
--
F
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
K
I
I
N
--
T
K
K
-------
L
-------
S
----
A
R
--
D
-----
H
----
Q
K---
L
E
------
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
----
H
Y
L
I
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
A
--
R
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
-
L
L
-
L
A
S
K
L
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
--
E
-----
V
--
E
---
G
EQQ
A
---
W
F
G
--
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
---
P
-----
Y
-
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
------
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
-------------
S
H
R
S
T
V
A
S
C
M
H
R
Q
E
T
V
D
C
L
K
----
K
F
N
--------------------------------------------------------------------------------------------
169
Blastp_CBE
71.29
35%
-59
- C1 -
-
4IEB
1
?
A:
[49-376]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
-------
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
M
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
-
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKEQISVDVP
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
28
Blastp_CBE
71.02
39%
-89
- C1 -
-
2JAM
3
KCC1G_HUMAN
B:
[4-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
N
I
R
K
T
-
F
I
F
-
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
--
K
--------------------------------
S
----
S
----
L
E
------
N
E
I
A
V
L
K
K
I
-
K
-
H
-
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
----
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
L
E
--
R
G
----
V
---
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
Y
L
T
-
P
E
E
N
S
K
I
M
I
T
D
F
G
L
S
--
K
--
M
-----
E
--
Q
N--
G
---
I
---
M
S
T
--
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
K
---
P
-----
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
------
Y
E
-
E
T
------
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
-
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
-------------
D
G
N
T
A
L
H
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
----
N
F
A
K
-------------------------------------------------------------------------------------------
29
Blastp_CBE
70.80
41%
-40
- C1 -
-
3BHH
1
KCC2B_HUMAN
B:
[2-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
D
E
-
Y
Q
L
-
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
--
T
K
K
-------
L
-------
S
----
A
R
--
D
-----
H
----
Q
K---
L
E
------
R
E
A
R
I
C
R
L
L
-
K
-
H
-
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
A
--
R
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
-
L
L
-
L
A
S
K
C
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
--
E
-----
V
--
Q
---
G
DQQ
A
---
W
F
G
--
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
E
---
A
-----
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
------
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
-------------
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
K
----
K
F
N
--------------------------------------------------------------------------------------------
15
PsiBlast_PDB
70.48
37%
-30
- C1 -
-
3SOA
1
KCC2A_HUMAN
A:
[11-318]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
-
Y
Q
L
-
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
--
T
K
K
-------
L
-------
S
----
A
R
--
D
-----
H
----
Q
K---
L
E
------
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
----
H
Y
L
I
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
A
--
R
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
-
L
L
-
L
A
S
K
L
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
--
E
-----
V
--
E
---
G
EQQ
A
---
W
F
G
--
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
---
P
-----
Y
-
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
------
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
-------------
S
H
R
S
T
V
A
S
C
M
H
R
Q
E
T
V
D
C
L
K
----
K
F
N
A
R
R
K
L
K
G
A
I
L
T
V
M
L
A
T
R
N
F
S
V
R
K
Q
--------------------------------------------------------------------
24
Blastp_CBE
70.40
43%
-81
- C1 -
-
4FG9
1
KCC1A_HUMAN
B:
[14-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
I
R
D
I
-
Y
D
F
-
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
--
K
---------------------------------------------------
E
I
A
V
L
H
K
I
-
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
E
--
K
G
----
F
---
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
--------------------------V--
L
S
T
--
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
K
---
P
-----
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
D
-
E
N
--
D
A
--
K
--
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
-------------
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
----
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
-------------------------------------------------------------------------------
298
Blastp_CBE
70.31
36%
-145
- C1 -
-
4BFM
1
MELK_MOUSE
A:
[7-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
A
-------
L
-------
G
----
S
D
--
L
-----
P
----
R
----
V
K
------
T
E
I
D
A
L
K
S
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
----
D
E
N
H
K
L
K
L
I
D
F
G
L
C
--
A
--
K
--------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
------
Q
-------------------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
Y
E
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
R
N
L
L
N
H
P
W
V
-------------
M
Q
D
Y
S
------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
70.23
40%
-40
- C1 -
-
3BHH
1
KCC2B_HUMAN
A:
[1-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
T
D
E
-
Y
Q
L
-
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
--
T
K
K
-------
L
-------
S
----
A
R
--
D
-----
H
----
Q
K---
L
E
------
R
E
A
R
I
C
R
L
L
-
K
-
H
-
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
A
--
R
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
-
L
L
-
L
A
S
K
C
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
--
E
-----
V
--
Q
---
G
DQQ
A
---
W
F
G
--
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
E
---
A
-----
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
------
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
-------------
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
K
----
K
F
N
--------------------------------------------------------------------------------------------
40
Blastp_CBE
69.88
38%
-115
- C1 -
-
2W4O
1
KCC4_HUMAN
A:
[43-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
G
---
S
N
R
D
A
L
S
D
F
-
F
E
V
-
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
--
K
----------------------------------------------------
I
G
V
L
L
R
L
-
S
-
H
-
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
----
I
S
L
V
L
E
L
V
T
G
G
E
L
-
F
D
R
I
V
E
--
K
G
----
Y
---
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
Y
A
T
-
P
A
P
D
A
P
L
K
I
A
D
F
------------------------------------
G
T
P
G
Y
C
A
P
E
I
L
------
R
------
G
C
---
A
-----
Y
-
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
------
Y
D
-
E
R
--
G
---
D
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
-
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
-------------
T
G
K
A
A
--
N
F
V
H
M
D
T
A
Q
K
K
L
Q
----
E
F
N
--------------------------------------------------------------------------------------------
11
PsiBlast_PDB
69.86
37%
-27
- C1 -
-
2V7O
3
KCC2G_HUMAN
A:
[15-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
N
L
Y
F
Q
S
M
A
T
C
T
R
F
T
D
D
-
Y
Q
L
-
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
--
T
K
K
-------
L
-------
S
----
A
R
--
D
-----
H
----
Q
K---
L
E
------
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
A
--
R
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
A
S
K
C
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
--
E
-----
V
--
Q
---
G
EQQ
A
---
W
F
G
--
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
---
P
-----
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
------
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
V
-------------
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
R
----
K
F
N
A
R
R
K
L
K
G
-------------------------------------------------------------------------------------
18
PsiBlast_PDB
69.58
39%
-44
- C1 -
-
2WEL
7
KCC2D_HUMAN
A:
[1-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
T
D
E
-
Y
Q
L
-
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
--
T
K
K
-------
L
-------
S
----
A
R
--
D
-----
H
----
Q
K---
L
E
------
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
A
--
R
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
--
E
-----
V
--
Q
---
G
DQQ
A
---
W
F
G
--
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
---
P
-----
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
------
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
-------------
C
Q
R
----
S
M
M
H
R
Q
E
T
V
D
C
L
K
----
K
F
N
--------------------------------------------------------------------------------------------
299
Blastp_CBE
69.20
36%
-145
- C1 -
-
4CQG
1
MELK_MOUSE
A:
[7-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
A
-------
L
-------
G
----
S
D
--
L
-----
P
----
R
----
V
K
------
T
E
I
D
A
L
K
S
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
----
D
E
N
H
K
L
K
L
I
D
F
G
L
C
--
A
--
K
--------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
------
Q
-------------------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
Y
E
V
P
K
--
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
R
N
L
L
N
H
P
W
V
-------------
M
Q
D
Y
S
------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
69.17
40%
-34
- C1 -
-
2VN9
1
KCC2D_HUMAN
B:
[1-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
T
D
E
-
Y
Q
L
-
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
--
T
K
K
-------
L
-------
S
----
A
R
--
D
-----
H
----
Q
K---
L
E
------
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
A
--
R
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
--
E
-----
V
--
Q
---
G
DQQ
A
---
W
F
G
--
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
---
P
-----
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
------
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
-------------
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
----
K
F
N
--------------------------------------------------------------------------------------------
23
Blastp_CBE
69.08
43%
-60
- C1 -
-
4FG8
1
KCC1A_HUMAN
B:
[14-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
I
R
D
I
-
Y
D
F
-
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
--
K
--------------------------------------------------
N
E
I
A
V
L
H
K
I
-
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
-
F
D
R
I
V
E
--
K
G
----
F
---
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
G
-------------------------GSV
L
S
T
--
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
K
---
P
-----
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
D
-
E
N
--
D
A
--
K
--
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
-------------
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
----
N
F
A
--------------------------------------------------------------------------------------------
265
Blastp_CBE
69.04
37%
-155
- C1 -
-
5TWY
1
MELK_HUMAN
A:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
T
---------------------
D
--
L
-----
P
----
R
----
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
G
L
---------------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
K
-----------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
68.81
40%
-29
- C1 -
-
6BAB
2
KCC2D_MOUSE
A:
[13-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
-
Y
Q
L
-
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
--
T
K
K
-------
L
-------
S
----
A
R
--
D
-----
H
----
Q
K---
L
E
------
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
A
--
R
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
--
E
-----
V
--
Q
---
G
DQQ
A
---
W
F
G
--
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
---
P
-----
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
------
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
-------------
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
----
K
F
N
--------------------------------------------------------------------------------------------
276
Blastp_CBE
68.79
37%
-150
- C1 -
-
4BKY
1
MELK_HUMAN
A:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
T
-------
L
-------------
D
--
L
-----
P
----
R
----
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
G
L
C
--
A
-------------------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
K
-----------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
68.51
40%
-35
- C1 -
-
2VN9
2
KCC2D_HUMAN
A:
[1-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
T
D
E
-
Y
Q
L
-
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
--
T
K
K
-------
L
-------
S
----
A
R
--
D
-----
H
----
Q
K---
L
E
------
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
A
--
R
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
--
E
-----
V
--
Q
---
G
DQQ
A
---
W
F
G
--
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
---
P
-----
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
------
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
-------------
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
----
K
F
N
--------------------------------------------------------------------------------------------
220
Blastp_CBE
68.36
35%
-60
- C1 -
-
3HX4
3
?
A:
[50-376]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
----------------------
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKEQISVDVP
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
275
Blastp_CBE
68.35
37%
-157
- C1 -
-
4BKZ
1
MELK_HUMAN
A:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
T
-------
L
----------------
L
-----
P
----
R
----
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
G
L
C
--
A
-------------------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
------------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
68.32
40%
-27
- C1 -
-
6AYW
2
KCC2D_HUMAN
A:
[13-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
-
Y
Q
L
-
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
--
T
K
K
-------
L
-------
S
----
A
R
--
D
-----
H
----
Q
K---
L
E
------
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
A
--
R
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
--
E
-----
V
--
Q
---
G
DQQ
A
---
W
F
G
--
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
---
P
-----
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
------
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
-------------
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
----
K
F
N
--------------------------------------------------------------------------------------------
20
PsiBlast_PDB
68.23
40%
-30
- C1 -
-
5VLO
2
KCC2D_HUMAN
A:
[13-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
-
Y
Q
L
-
F
E
E
L
G
---
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
--
T
K
K
-------
L
-------
S
----
A
R
--
D
-----
H
----
Q
K---
L
E
------
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
A
--
R
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
--
E
-----
V
--
Q
---
G
DQQ
A
---
W
F
G
--
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
---
P
-----
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
------
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
-------------
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
----
K
F
N
--------------------------------------------------------------------------------------------
31
Blastp_CBE
68.00
40%
-27
- C1 -
-
6BAB
1
KCC2D_MOUSE
D:
[13-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
-
Y
Q
L
-
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
--
T
K
K
-------
L
-------
S
----
A
R
--
D
-----
H
----
Q
K---
L
E
------
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
A
--
R
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
--
E
-----
V
--
Q
---
G
DQQ
A
---
W
F
G
--
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
---
P
-----
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
------
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
-------------
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
----
K
F
N
--------------------------------------------------------------------------------------------
37
Blastp_CBE
67.88
40%
-29
- C1 -
-
5VLO
2
KCC2D_HUMAN
B:
[13-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
-
Y
Q
L
-
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
--
T
K
K
-------
L
-------
S
----
A
R
--
D
-----
H
----
Q
K---
L
E
------
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
A
--
R
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
--
E
-----
V
--
Q
---
G
DQQ
A
---
W
F
G
--
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
---
P
-----
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
------
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
-------------
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
----
K
F
N
--------------------------------------------------------------------------------------------
35
Blastp_CBE
67.84
40%
-27
- C1 -
-
6AYW
2
KCC2D_HUMAN
B:
[13-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
-
Y
Q
L
-
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
--
T
K
K
-------
L
-------
S
----
A
R
--
D
-----
H
----
Q
K---
L
E
------
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
A
--
R
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
--
E
-----
V
--
Q
---
G
DQQ
A
---
W
F
G
--
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
---
P
-----
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
------
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
-------------
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
----
K
F
N
--------------------------------------------------------------------------------------------
274
Blastp_CBE
67.83
37%
-151
- C1 -
-
4BL1
1
MELK_HUMAN
A:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
T
-------
L
----------------
L
-----
P
----
R
----
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
G
L
C
--
A
--
K
----------------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
K
-----------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
67.71
34%
-10
- C1 -
-
3C0H
1
CSKP_HUMAN
A:
[19-318]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
-
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
--
V
A
K
-------
F
-------
T
----
S
S
--
P
-----
G
----
L
STED
L
K
------
R
E
A
S
I
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--
A
D
----
A
GFV
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
-
V
L
-
L
A
S
-
K
E
N
S
A
P
V
K
L
G
G
F
G
V
A
--
I
--
Q
-----
L
G-
E
---
S
---
G
---
L
V
A
GG
R
V
G
T
P
H
F
M
A
P
E
V
V
------
K
------
R
E
---
P
-----
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
G
-
T
-------
K
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
-------------
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
----
K
F
N
A
R
R
K
L
---------------------------------------------------------------------------------------
262
Blastp_CBE
67.56
37%
-117
- C1 -
-
5TVT
1
MELK_HUMAN
A:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
T
-------
L
-------
G
----
S
D
--
L
-----
P
----
R
----
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
G
L
C
--
A
--
K
---------------------------
G
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
K
---
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
67.37
40%
-31
- C1 -
-
6BAB
2
KCC2D_MOUSE
C:
[14-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
Y
Q
L
-
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
----
Q
E
Y
A
A
K
I
I
N
--
T
K
K
-------
L
-------
S
----
A
R
--
D
-----
H
----
Q
K---
L
E
------
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
A
--
R
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
--
E
-----
V
--
Q
---
G
DQQ
A
---
W
F
G
--
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
---
P
-----
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
------
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
-------------
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
----
K
F
N
--------------------------------------------------------------------------------------------
106
Blastp_CBE
67.28
38%
-150
- C1 -
-
3ZXT
1
DAPK1_HUMAN
D:
[13-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
---------------------
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
-------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
-------------------
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
----------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
67.02
37%
-141
- C1 -
-
6GVX
2
MELK_HUMAN
B:
[11-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
T
--------------------
S
D
--
L
-----
P
----
R
----
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
G
L
C
--
A
--
K
-----
P
---------------------
G
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
------------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
66.88
35%
-118
- C1 -
-
4UMQ
1
MELK_HUMAN
A:
[25-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
T
-------
L
-------
G
----
S
D
--
L
-----
P
----
R
----
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
G
L
---------------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
K
---
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---------
D
D
--
D
T
--
A
A
A
L
V
A
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
270
Blastp_CBE
66.73
37%
-122
- C1 -
-
5MAH
2
MELK_HUMAN
A:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
T
-------
L
-------
G
----
S
D
--
L
-----
P
----
R
----
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
G
L
C
--
A
--
K
----------------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
K
----------L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
277
Blastp_CBE
66.66
37%
-117
- C1 -
-
5K00
1
MELK_HUMAN
A:
[6-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
T
-------
L
-------
G
----
S
D
--
L
-----
P
----
R
----
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
G
L
C
--
A
--
K
-----
P
----------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
K
---
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
66.66
37%
-119
- C1 -
-
5TWL
1
MELK_HUMAN
A:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
T
-------
L
-------
G
----
S
D
--
L
-----
P
----
R
----
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
G
L
---------------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
K
---
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
66.54
35%
-6
- C1 -
-
3MFR
1
CSKP_HUMAN
A:
[19-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
-
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
--
V
A
K
-------
F
-------
T
----
S
S
--
P
-----
G
----
L
STED
L
K
------
R
E
A
S
I
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--
A
D
----
A
GFV
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
-
V
L
-
L
A
S
-
K
E
N
S
A
P
V
K
L
G
D
F
G
V
A
--
I
--
Q
-----
L
G-
E
---
S
---
G
---
L
V
A
GG
R
V
G
T
P
H
F
M
A
P
E
V
V
------
K
------
R
E
---
P
-----
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
G
-
T
-------
K
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
-------------
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
----
K
F
N
A
R
R
K
L
K
G
-------------------------------------------------------------------------------------
287
Blastp_CBE
66.37
34%
-3
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[19-327]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
-
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
--
V
A
K
-------
F
-------
T
----
S
S
--
P
-----
G
----
L
STED
L
K
------
R
E
A
S
I
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--
A
D
----
A
GFV
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
-
V
L
-
L
A
S
-
K
E
N
S
A
P
V
K
L
G
G
F
G
V
A
--
I
--
Q
-----
L
G-
E
---
S
---
G
---
L
V
A
GG
R
V
G
T
P
H
F
M
A
P
E
V
V
------
K
------
R
E
---
P
-----
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
G
-
T
-------
K
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
-------------
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
----
K
F
N
A
R
R
K
L
K
G
A
V
L
A
A
V
S
------------------------------------------------------------------------------
172
Blastp_CBE
66.33
35%
-5
- C1 -
-
3MFS
1
CSKP_HUMAN
A:
[18-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
V
L
F
E
D
V
Y
E
L
-
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
--
V
A
K
-------
F
-------
T
----
S
S
--
P
-----
G
----
L
STED
L
K
------
R
E
A
S
I
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--
A
D
----
A
GFV
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
-
V
L
-
L
A
S
-
K
E
N
S
A
P
V
K
L
G
D
F
G
V
A
--
I
--
Q
-----
L
G-
E
---
S
---
G
---
L
V
A
GG
R
V
G
T
P
H
F
M
A
P
E
V
V
------
K
------
R
E
---
P
-----
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
G
-
T
-------
K
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
-------------
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
----
K
F
N
A
R
R
K
L
K
G
-------------------------------------------------------------------------------------
263
Blastp_CBE
66.32
37%
-122
- C1 -
-
5TWZ
1
MELK_HUMAN
A:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
T
-------
L
-------
G
----
S
D
--
L
-----
P
----
R
----
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
G
-----------------------------------
G
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
K
---
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
66.30
40%
-26
- C1 -
-
6BAB
2
KCC2D_MOUSE
B:
[14-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
Y
Q
L
-
F
E
E
L
G
----
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
--
T
K
K
-------
L
-------
S
----
A
R
--
D
-----
H
----
Q
K---
L
E
------
R
E
A
R
I
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
A
--
R
E
----
Y
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
--
E
-----
V
--
Q
---
G
DQQ
A
---
W
F
G
--
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
---
P
-----
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
------
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
-------------
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
----
K
F
N
--------------------------------------------------------------------------------------------
292
Blastp_CBE
66.23
36%
-118
- C1 -
-
4UMT
2
MELK_HUMAN
A:
[23-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
D
E
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
T
-------
L
-------
G
----
S
D
--
L
-----
P
----
R
----
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
G
L
---------------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
K
---
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---------
D
D
--
D
T
--
A
A
A
L
V
A
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
66.23
37%
-125
- C1 -
-
5IHC
1
MELK_HUMAN
A:
[6-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
T
-------
L
-------
G
----
S
D
--
L
-----
P
----
R
----
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
------------------------------------
G
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
K
---
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
285
Blastp_CBE
66.05
34%
-8
- C1 -
-
3C0H
1
CSKP_HUMAN
B:
[19-318]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
-
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
--
V
A
K
-------
F
-------
T
----
S
S
--
P
-----
G
----
L
STED
L
K
------
R
E
A
S
I
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--
A
D
----
A
GFV
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
-
V
L
-
L
A
S
-
K
E
N
S
A
P
V
K
L
G
G
F
G
V
A
--
I
--
Q
-----
L
G-
E
---
S
---
G
---
L
V
A
GG
R
V
G
T
P
H
F
M
A
P
E
V
V
------
K
------
R
E
---
P
-----
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
G
-
T
-------
K
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
-------------
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
----
K
F
N
A
R
R
K
L
---------------------------------------------------------------------------------------
273
Blastp_CBE
66.03
37%
-120
- C1 -
-
5M5A
1
MELK_HUMAN
A:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
T
-------
L
-------
G
----
S
D
--
L
-----
P
----
R
----
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
G
L
C
--
A
-------------------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
K
----------L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
65.88
35%
-2
- C1 -
-
3MFU
1
CSKP_HUMAN
A:
[19-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
F
E
D
V
Y
E
L
-
C
E
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
--
V
A
K
-------
F
-------
T
----
S
S
--
P
-----
G
----
L
STED
L
K
------
R
E
A
S
I
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--
A
D
----
A
GFV
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
-
V
L
-
L
A
S
-
K
E
N
S
A
P
V
K
L
G
D
F
G
V
A
--
I
--
Q
-----
L
G-
E
---
S
---
G
---
L
V
A
GG
R
V
G
T
P
H
F
M
A
P
E
V
V
------
K
------
R
E
---
P
-----
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
G
-
T
-------
K
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
-------------
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
----
K
F
N
A
R
R
K
L
K
G
-------------------------------------------------------------------------------------
280
Blastp_CBE
65.87
37%
-118
- C1 -
-
5IH9
1
MELK_HUMAN
A:
[6-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
T
------------------------
L
-----
P
----
R
----
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
G
L
C
--
A
--
K
----------------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
K
---
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
65.82
42%
-46
- C1 -
-
5FG8
3
KCC2A_DROME
A:
[14-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
-
Y
D
I
-
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
N
--
T
K
K
-------
L
-------
T
----
A
R
--
D
F----
Q
----
K
----
L
E
------
R
E
A
R
I
C
R
K
L
-
H
-
H
-
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
A
--
R
E
----
F
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
-
L
L
-
L
A
S
K
A
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
--
E
-----
V
--
Q
---
G
DHQ
A
---
W
F
G
--
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
K
------
K
E
---
P
-----
Y
-
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
------
Q
H
R
L
Y
S
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
-
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
T
A
A
E
A
L
K
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
65.46
34%
-11
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[20-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
F
E
D
V
Y
E
L
-
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
--
V
A
K
-------
F
-------
T
----
S
S
--
P
-----
G
----
L
STED
L
K
------
R
E
A
S
I
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--
A
D
----
A
GFV
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
-
V
L
-
L
A
S
-
K
E
N
S
A
P
V
K
L
G
G
F
G
V
A
--
I
--
Q
-----
L
G-
E
---
S
---
G
---
L
V
A
GG
R
V
G
T
P
H
F
M
A
P
E
V
V
------
K
------
R
E
---
P
-----
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
G
-
T
-------
K
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
-------------
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
----
K
F
N
A
R
R
K
----------------------------------------------------------------------------------------
233
Blastp_CBE
65.43
35%
-8
- C1 -
-
5W9E
1
?
A:
[26-360]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKDVP-----
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
500
Blastp_CBE
65.36
35%
-55
- C1 -
-
3F3Z
5
?
A:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
-
Y
T
L
-
E
N
T
I
G
R
G
S
W
G
E
V
K
I
A
V
Q
K
G
T
R
I
R
R
A
A
K
K
I
P
--
K
Y
F
-------
V
-------
E
----
D
V
--
D
-----
R
----
F
-----
K
------
Q
E
I
E
I
M
K
S
L
-
D
-
H
-
P
N
I
I
R
L
Y
E
T
F
E
D
N
T
D
----
I
Y
L
V
M
E
L
C
T
G
G
E
L
-
F
E
R
V
V
H
--
K
R
----
V
---
F
R
E
S
D
A
A
R
I
M
K
D
V
L
S
A
V
A
Y
C
H
K
L
N
V
A
H
R
D
L
K
P
E
N
F
L
F
-
L
T
D
S
P
D
S
--
P
L
K
L
I
D
F
G
L
A
--
A
--
R
-----
F
--
K
PG-
K
---
M
---
M
R
T
--
K
V
G
T
P
Y
Y
V
S
P
Q
V
L
-------------
E
G
---
L
-----
Y
-
G
P
E
C
D
E
W
S
A
G
V
M
M
Y
V
L
L
C
G
Y
P
P
F
------
S
A
-
P
T
--
D
S
----
E
V
M
L
K
I
R
E
G
T
F
T
F
P
E
K
D
W
L
-
N
V
S
P
Q
A
E
S
L
I
R
R
L
L
T
K
S
P
K
Q
R
I
T
S
L
Q
A
L
E
H
E
W
F
-------------
E
K
Q
L
S
------------------------------------------------------------------------------------------------------------------
291
Blastp_CBE
65.33
36%
-115
- C1 -
-
4UMU
1
MELK_HUMAN
A:
[23-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
D
E
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
T
-------
L
-------
G
----
S
D
--
L
-----
P
----
R
----
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
G
L
---------------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
K
---
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---------
D
D
--
D
T
--
A
A
A
L
V
A
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
218
Blastp_CBE
65.33
35%
-6
- C1 -
-
4IFG
1
?
A:
[49-382]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKDVP-----
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
239
Blastp_CBE
65.30
35%
-5
- C1 -
-
4WG4
1
?
A:
[26-358]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKDVP-----
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
269
Blastp_CBE
65.26
37%
-123
- C1 -
-
5MAI
2
MELK_HUMAN
A:
[8-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
T
-------
L
-------
G
----
S
D
--
L
-----
P
----
R
----
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
-------------------------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
K
---
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
65.05
35%
-6
- C1 -
-
4TZR
1
?
A:
[26-352]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKDVP-----
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
272
Blastp_CBE
65.04
37%
-119
- C1 -
-
5MAF
2
MELK_HUMAN
A:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
T
-------
L
-------------
D
--
L
-----
P
----
R
----
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
G
L
C
--
A
--
K
----------------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
K
----------L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
65.02
35%
-4
- C1 -
-
3V5T
1
?
A:
[26-352]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKDVP-----
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
281
Blastp_CBE
64.99
37%
-120
- C1 -
-
5IH8
1
MELK_HUMAN
A:
[6-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
T
---------------------
D
--
L
-----
P
----
R
----
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
G
L
C
--
A
--
K
----------------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
K
---
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
64.98
35%
-0
- C1 -
-
3UPX
1
?
A:
[26-365]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKVP------
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
279
Blastp_CBE
64.89
37%
-125
- C1 -
-
5IHA
1
MELK_HUMAN
A:
[6-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
----
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
T
-------
L
---------------------------
R
----
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
G
L
C
--
A
--
K
----------------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
K
---
S
-----
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
588
HHSearch
64.85
37%
-50
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[22-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
V
-
Y
E
L
-
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
--
V
A
K
-------
F
-------
T
SSPG
L
S
--
T
-----
E
----
D
----
L
K
------
R
E
A
S
I
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
M
V
F
E
F
M
D
G
A
D
L
-
C
F
E
I
V
K
--
R
A
DAGF
V
---
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
-
V
L
-
L
A
S
K
-
E
N
S
A
P
V
K
L
G
G
F
G
V
A
--
I
--
Q
-----
L
--
G
---
E
---
S
GLV
A
G
G
--
R
V
G
T
P
H
F
M
A
P
E
V
V
------
K
------
R
E
---
P
-----
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
G
-
T
K
--
E
-----
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
-------------
K
E
R
D
-------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
64.69
37%
-159
- C1 -
-
5TX3
2
MELK_HUMAN
A:
[11-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
-----------------------------------------
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
G
L
----------------------------------
G
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
K
-----------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
64.64
37%
-117
- C1 -
-
5MAG
3
MELK_HUMAN
A:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
T
G
G
-
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
T
-------
L
-------------
D
--
L
-----
P
----
R
----
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
G
L
C
--
A
--
K
----------------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
K
----------L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
583
HHSearch
64.63
41%
-18
- C1 -
-
2Y7J
1
PHKG2_HUMAN
A:
[91-364]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
Y
Q
K
-
Y
D
P
-
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
--
V
T
A
-------
E
RLSPEQL
E
----
E
V
--
R
-----
E
----
A
----
T
R
------
R
E
T
H
I
L
R
Q
V
A
G
-
H
-
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
----
M
F
L
V
F
D
L
M
R
K
G
E
L
-
F
D
Y
L
T
E
--
K
V
----
A
---
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
-
I
L
-
L
----
D
D
N
M
Q
I
R
L
S
D
F
G
F
S
--
C
--
H
-----
L
--
E
---
P
---
G
EK-
L
R
E
--
L
C
G
T
P
G
Y
L
A
P
E
I
L
------
K
CSMDET
H
P
---
G
-----
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
------
W
H
-
R
R
--
Q
I
----
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
-
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
-------------
E
----------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
64.57
35%
-4
- C1 -
-
3SX9
1
?
A:
[26-356]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKDVP-----
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
17
PsiBlast_PDB
64.55
42%
-47
- C1 -
-
5H9B
2
KCC2A_DROME
A:
[14-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
-
Y
D
I
-
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
N
--
T
K
K
-------
L
-------
T
----
A
R
--
D
F----
Q
----
K
----
L
E
------
R
E
A
R
I
C
R
K
L
-
H
-
H
-
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
A
--
R
E
----
F
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
-
L
L
-
L
A
S
K
A
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
--
E
-----
V
--
Q
---
G
DHQ
A
---
W
F
G
--
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
K
------
K
E
---
P
-----
Y
-
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
------
Q
H
R
L
Y
S
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
-
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
T
A
A
E
A
L
K
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
64.53
35%
-9
- C1 -
-
5DVR
1
?
A:
[67-510]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
---------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
K--
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYP---------
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
264
Blastp_CBE
64.35
37%
-156
- C1 -
-
5TWY
1
MELK_HUMAN
B:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
----------------------
D
--
L
-----
P
----
R
----
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
G
L
C
-----------------------------------
L
A
Y
A
A
P
E
L
I
------
Q
------
G
K
-----------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
64.36
38%
-18
- C1 -
-
2YAA
1
DAPK2_MOUSE
B:
[14-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
-
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
--
K
R
Q
SRASRRG
V
-------
C
----
R
E
--
E
---------------
I
E
------
R
E
V
S
I
L
R
Q
V
-
L
-
H
-
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
Q
--
K
E
----
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
--
H
--
E
-----
I
--
E
---
D
GV-
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
-
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
-------------
T
P
V
D
T
Q
Q
A
M
V
R
R
E
----------------------------------------------------------------------------------------------------------
240
Blastp_CBE
64.35
35%
-7
- C1 -
-
4WG3
1
?
A:
[26-352]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKDVP-----
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
19
PsiBlast_PDB
64.35
42%
-47
- C1 -
-
5HU3
1
KCC2A_DROME
A:
[14-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
-
Y
D
I
-
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
N
--
T
K
K
-------
L
-------
T
----
A
R
--
D
F----
Q
----
K
----
L
E
------
R
E
A
R
I
C
R
K
L
-
H
-
H
-
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
-
F
E
D
I
V
A
--
R
E
----
F
---
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
N
L
K
P
E
N
-
L
L
-
L
A
S
K
A
K
G
A
-
A
V
K
L
A
D
F
G
L
A
--
I
--
E
-----
V
--
Q
---
G
DHQ
A
---
W
F
G
--
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
K
------
K
E
---
P
-----
Y
-
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
------
Q
H
R
L
Y
S
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
-
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
T
A
A
E
A
L
K
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
64.33
34%
-82
- C1 -
-
4BDG
2
CHK2_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
-------------------------------------
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
GE
T
---
S
---
L
---
M
R
T
--
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
E
S
T
----------------------------------------------------------------------------------
189
Blastp_CBE
64.21
34%
-82
- C1 -
-
4BDF
3
CHK2_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
-------------------------------------
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
GE
T
---
S
---
L
---
M
R
T
--
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
E
S
T
----------------------------------------------------------------------------------
221
Blastp_CBE
64.19
35%
-11
- C1 -
-
5T6K
1
?
A:
[67-510]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
K--
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYP---------
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
268
Blastp_CBE
64.15
37%
-95
- C1 -
-
6GVX
3
MELK_HUMAN
A:
[11-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
T
--
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
N
T
---------------------
D
--
L
-----
P
----
R
----
I
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
F
G
L
C
--
A
--
K
-----
P
--
K
---
G
NK-----------
C
G
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
K
-----------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
64.15
35%
1
- C1 -
-
3UPZ
1
?
A:
[26-352]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKVP------
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
589
HHSearch
64.00
37%
-48
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[22-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
V
-
Y
E
L
-
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
--
V
A
K
-------
F
TSSP---
G
----
L
S
--
T
-----
E
----
D
----
L
K
------
R
E
A
S
I
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
M
V
F
E
F
M
D
G
A
D
L
-
C
F
E
I
V
K
--
R
A
DAGF
V
---
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
-
V
L
-
L
A
S
K
-
E
N
S
A
P
V
K
L
G
G
F
G
V
A
--
I
--
Q
-----
L
--
G
---
E
---
S
GLV
A
G
G
--
R
V
G
T
P
H
F
M
A
P
E
V
V
------
K
------
R
E
---
P
-----
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
G
-
T
K
--
E
-----
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
-------------
K
E
R
D
-------------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
63.98
35%
2
- C1 -
-
5W80
1
?
A:
[26-359]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKVDVP----
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
244
Blastp_CBE
63.97
35%
-4
- C1 -
-
4JBV
1
?
A:
[26-352]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKDVP-----
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
246
Blastp_CBE
63.86
35%
3
- C1 -
-
3V5P
1
?
A:
[26-361]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKVP------
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
225
Blastp_CBE
63.84
35%
1
- C1 -
-
5JMS
2
?
A:
[67-404]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKVP------
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
182
Blastp_CBE
63.79
34%
-80
- C1 -
-
2YCR
1
CHK2_HUMAN
A:
[8-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
-------------------------------------
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
GE
T
---
S
---
L
---
M
R
T
--
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
K
P
Q
------------------------------------------------------------------------------
455
Blastp_CBE
63.62
38%
-69
- C1 -
-
4YUQ
1
?
B:
[30-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
S
--
K
R
Q
----------------------------------------
L
L
------
K
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
T
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
N
K
R
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
S
TK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
--
E
F
----
D
I
L
K
K
V
E
K
G
K
F
T
F
D
L
P
Q
W
K
-
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
S
A
R
D
A
L
E
H
E
W
L
------------------------------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
63.46
34%
-84
- C1 -
-
4BDD
3
CHK2_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
-------------------------------------
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
--
T
---
S
---
L
---
M
R
T
--
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
E
S
T
----------------------------------------------------------------------------------
85
Blastp_CBE
63.45
38%
-14
- C1 -
-
2YAA
1
DAPK2_MOUSE
A:
[14-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
-
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
--
K
R
Q
SRASRRG
V
-------
C
----
R
E
--
E
---------------
I
E
------
R
E
V
S
I
L
R
Q
V
-
L
-
H
-
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
Q
--
K
E
----
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
--
H
--
E
-----
I
--
E
---
D
GV-
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
-
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
-------------
T
P
V
D
T
Q
Q
A
M
V
R
R
E
----------------------------------------------------------------------------------------------------------
187
Blastp_CBE
63.32
34%
-86
- C1 -
-
4BDH
4
CHK2_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
-------------------------------------
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
GE
T
---
S
---
L
---
M
R
T
--
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
E
S
T
----------------------------------------------------------------------------------
194
Blastp_CBE
63.22
34%
-86
- C1 -
-
4BDA
8
CHK2_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
-------------------------------------
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
E-
T
---
S
---
L
---
M
R
T
--
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
E
S
T
----------------------------------------------------------------------------------
210
Blastp_CBE
63.19
34%
-78
- C1 -
-
2YIQ
1
CHK2_HUMAN
A:
[8-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
------------------------------------------
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
GE
T
---
S
---
L
---
M
R
T
--
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
E
S
T
----------------------------------------------------------------------------------
207
Blastp_CBE
63.18
34%
-81
- C1 -
-
2CN5
1
CHK2_HUMAN
A:
[14-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
R
------------------------------------
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
GE
T
---
S
---
L
---
M
R
T
--
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
E
------------------------------------------------------------------------------------
211
Blastp_CBE
63.15
34%
-78
- C1 -
-
2YCS
1
CHK2_HUMAN
A:
[8-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
-------------------------------------
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
--
T
---
S
---
L
---
M
R
T
--
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
E
S
T
----------------------------------------------------------------------------------
152
Blastp_CBE
63.13
38%
-24
- C1 -
-
3LIJ
1
?
A:
[30-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
K
G
H
L
S
E
M
-
Y
Q
R
-
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
--
K
------------------S---
S
N
--
S
-----
K
----
L
----
L
E
-------
E
V
A
V
L
K
L
L
-
D
-
H
-
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
----
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
-
F
D
E
I
I
H
--
R
M
----
K
---
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
E
K
D
A
L
I
K
I
V
D
F
G
L
S
--
A
--
V
-----
F
--
E
---
N
QK-
K
---
M
K
E
--
R
L
G
T
A
Y
Y
I
A
P
E
V
L
------
R
------
K
K
---------
Y
-
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
------
G
G
-
Q
T
--
D
----
Q
E
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
-
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
-------------
K
E
M
C
S
K
K
----------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
62.90
34%
-88
- C1 -
-
4BDJ
1
CHK2_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
-----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
-------------------------------------
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
E-
T
---
S
---
L
---
M
R
T
--
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
E
S
T
----------------------------------------------------------------------------------
63
Blastp_CBE
62.84
39%
-42
- C1 -
-
3IGO
8
?
A:
[19-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
A
E
R
-
Y
N
I
-
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
--
K
A
S
-------
A
-------
K
----
N
K
---T----
S
----
T
----
I
L
------
R
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
----
F
Y
I
V
G
E
L
Y
T
G
G
E
L
-
F
D
E
I
I
K
--
R
K
----
R
---
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
-
I
L
-
L
-
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
--
T
--
C
-----
F
--
Q
---
Q
NT-------------
T
A
Y
Y
I
A
P
E
V
L
------
R
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
------
Y
G
-
K
N
------
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
-
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
-------------
Q
K
Y
S
S
E
-----------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
62.77
38%
-130
- C1 -
-
3ZXT
1
DAPK1_HUMAN
A:
[13-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
-------------
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
-
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
---------------------
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
----------------------------------------------------------------------------------------------------------------------
52
Blastp_CBE
62.42
40%
-15
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[94-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
-
Y
D
P
-
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V-
T
A
E
-------
R
-------
L
----
S
P
--
E
-----
Q
----
L
----
E
E
VREATR
R
E
T
H
I
L
R
Q
V
-
A
G
H
-
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
----
M
F
L
V
F
D
L
M
R
K
G
E
L
-
F
D
Y
L
T
E
--
K
V
----
A
---
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
-
I
L
-
L
----
D
D
N
M
Q
I
R
L
S
D
F
G
F
S
--
C
--
H
-----
L
--
E
PG-
E
---
K
---
L
R
E
--
L
C
G
T
P
G
Y
L
A
P
E
I
L
KCSMDE
T
------
H
P
---
G
-----
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
------
W
H
-
R
R
--
Q
I
--
L
--
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
-
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
-------------------------------------------------------------------------------------------------------------------------------------
456
Blastp_CBE
62.29
38%
-71
- C1 -
-
4YUQ
1
?
A:
[30-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
S
--
K
R
Q
-----------------------------------
L
----
L
L
------
K
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
T
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
N
K
R
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
S
TK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
--
E
F
----
D
I
L
K
K
V
E
K
G
K
F
T
F
D
L
P
Q
W
K
-
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
S
A
R
D
A
L
E
H
E
W
L
------------------------------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
62.27
38%
-72
- C1 -
-
4YSJ
1
?
B:
[30-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
S
--
K
R
-----------------------------------------
L
L
------
K
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
T
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
N
K
R
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
S
TK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
--
E
F
----
D
I
L
K
K
V
E
K
G
K
F
T
F
D
L
P
Q
W
K
-
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
S
A
R
D
A
L
E
H
E
W
L
------------------------------------------------------------------------------------------------------------------------------------
60
Blastp_CBE
62.09
39%
-37
- C1 -
-
4Y5Q
1
?
A:
[19-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
A
E
R
-
Y
N
I
-
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
--
K
A
S
-------
A
-------
K
----
N
K
--
D
T----
S
----
T
----
I
L
------
R
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
----
F
Y
I
V
G
E
L
Y
T
G
G
E
L
-
F
D
E
I
I
K
--
R
K
----
R
---
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
-
I
L
-
L
-
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
--
T
--
C
-----
F
--
Q
---
Q
NT-------
D
--
R
I
G
T
A
Y
Y
I
A
P
E
V
L
------
R
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
------
Y
G
-
K
N
------
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
-
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
-------------
Q
K
Y
S
S
E
-----------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
62.03
35%
6
- C1 -
-
5W91
1
?
A:
[26-359]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKVP------
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
-
N
G
D
G
Q
L
-----------------------------------------------------------------
51
Blastp_CBE
62.02
40%
-21
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[94-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
-
Y
D
P
-
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V-----------
R
-------
L
----
S
P
--
E
-----
Q
----
L
----
E
E
VREATR
R
E
T
H
I
L
R
Q
V
-
A
G
H
-
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
----
M
F
L
V
F
D
L
M
R
K
G
E
L
-
F
D
Y
L
T
E
--
K
V
----
A
---
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
-
I
L
-
L
----
D
D
N
M
Q
I
R
L
S
D
F
G
F
S
--
C
--
H
-----
L
--
E
PG-
E
---
K
---
L
R
E
--
L
C
G
T
P
G
Y
L
A
P
E
I
L
KCSMDE
T
------
H
P
---
G
-----
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
------
W
H
-
R
R
--
Q
I
--
L
--
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
-
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
-------------------------------------------------------------------------------------------------------------------------------------
235
Blastp_CBE
62.00
35%
-5
- C1 -
-
5W8R
1
?
A:
[26-358]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKEQVDVP--
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
62
Blastp_CBE
61.79
39%
-33
- C1 -
-
3MWU
1
?
A:
[19-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
A
E
R
-
Y
N
I
-
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
--
K
A
S
-------
A
-------
K
----
N
K
--
D
T----
S
----
T
----
I
L
------
R
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
----
F
Y
I
V
G
E
L
Y
T
G
G
E
L
-
F
D
E
I
I
K
--
R
K
----
R
---
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
-
I
L
-
L
-
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
--
T
--
C
-----
F
--
Q
---
Q
N--------
D
--
R
I
G
T
A
Y
Y
I
A
P
E
V
L
------
R
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
------
Y
G
-
K
N
------
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
-
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
-------------
Q
K
Y
S
S
E
-----------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
61.71
39%
5
- C1 -
-
1QL6
1
PHKG1_RABIT
A:
[15-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
E
N
-
Y
E
P
-
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
VT
G
G
G
-------
S
-------
F
----
S
A
--
E
-----
E
----
V
----
Q
E
LREATL
K
E
V
D
I
L
R
K
V
-
S
G
H
-
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
----
F
F
L
V
F
D
L
M
K
K
G
E
L
-
F
D
Y
L
T
E
--
K
V
----
T
---
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
-
I
L
-
L
----
D
D
D
M
N
I
K
L
T
D
F
G
F
S
--
C
--
Q
-----
L
--
D
PG-
E
---
K
---
L
R
S
--
V
C
G
T
P
S
Y
L
A
P
E
I
I
------
E
CSMNDN
H
P
---
G
-----
Y
-
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
------
W
H
-
R
K
--
Q
M
--
L
--
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
-
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
-------------
Q
Q
Y
V
-------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
61.63
38%
7
- C1 -
-
6FHB
2
DAPK1_HUMAN
A:
[16-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
D
T
Q
Q
----------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
61.55
37%
1
- C1 -
-
2CKE
1
DAPK2_HUMAN
B:
[14-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
-
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
--
K
R
Q
-------
S
RASRRG-
V
----
S
R
--
E
-----
E
---------
I
E
------
R
E
V
S
I
L
R
Q
V
-
L
-
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
Q
--
K
E
----
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
--
H
--
E
-----
I
--
E
---
D
GV-
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
-
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
-------------
T
P
V
D
N
Q
Q
A
M
V
R
R
E
----------------------------------------------------------------------------------------------------------
47
Blastp_CBE
61.54
40%
-31
- C1 -
-
2WEI
1
?
A:
[19-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
A
E
R
-
Y
N
I
-
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
--
K
A
S
-------
A
-------
K
----
N
K
--
D
T----
S
----
T
----
I
L
------
R
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
----
F
Y
I
V
G
E
L
Y
T
G
G
E
L
-
F
D
E
I
I
K
--
R
K
----
R
---
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
-
I
L
-
L
-
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
--
T
--
C
-----
F
--
Q
---
Q
NT-
K
---
M
K
D
--
R
I
G
T
A
Y
Y
I
A
P
E
V
L
------
R
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
------
Y
G
-
K
N
------
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
-
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
-------------
Q
K
Y
S
S
E
-----------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
61.46
36%
6
- C1 -
-
5VJA
2
DAPK3_HUMAN
B:
[1-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
V
E
D
H
-
Y
E
M
-
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
--
K
--------------------------
R
RGVSR
E
----
E
----
I
E
------
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
--
K
-----
I
--
E
---
A
GN-
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
E
T
------
K
Q
E
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
-------------
K
--
A
I
------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
61.37
40%
-11
- C1 -
-
2Y7J
1
PHKG2_HUMAN
A:
[94-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
-
Y
D
P
-
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V-
T
A
E
-------
R
-------
L
----
S
P
--
E
-----
Q
----
L
----
E
E
VREATR
R
E
T
H
I
L
R
Q
V
-
A
G
H
-
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
----
M
F
L
V
F
D
L
M
R
K
G
E
L
-
F
D
Y
L
T
E
--
K
V
----
A
---
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
-
I
L
-
L
----
D
D
N
M
Q
I
R
L
S
D
F
G
F
S
--
C
--
H
-----
L
--
E
PG-
E
---
K
---
L
R
E
--
L
C
G
T
P
G
Y
L
A
P
E
I
L
KCSMDE
T
------
H
P
---
G
-----
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
------
W
H
-
R
R
--
Q
I
--
L
--
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
-
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
-------------------------------------------------------------------------------------------------------------------------------------
359
Blastp_CBE
61.35
36%
-121
- C1 -
-
5XZV
1
RAD53_YEAST
A:
[200-465]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
D
E
V
V
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
A
V
K
I
I
S
--
K
R
K
-------
V
-------
I
----
G
N
--
M
-----
D
----
G
----
V
T
------
R
E
L
E
V
L
Q
K
L
-
N
-
H
-
P
R
I
V
R
L
K
G
F
Y
E
D
T
E
S
----
Y
Y
M
V
M
E
F
V
S
G
G
D
L
-
M
D
F
V
A
A
--
H
G
----
A
---
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
-
I
L
-
I
E
Q
--
D
D
P
V
L
V
K
I
T
D
F
G
L
A
--
K
--------------------------------
L
A
Y
V
A
P
E
V
I
--------------
N
---
E
-----
Y
-
S
S
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
---------
S
T
------
Q
D
Q
L
Y
K
Q
I
G
R
G
S
------
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
---
D
P
N
N
--
T
A
A
K
A
L
N
H
P
W
-------------------------------------------------------------------------------------------------------------------------------------
358
Blastp_CBE
61.32
36%
-113
- C1 -
-
5XZV
1
?
B:
[200-467]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
D
E
V
V
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
A
V
K
I
I
S
--
K
R
K
------------------------
M
-----
D
----
G
----
V
T
------
R
E
L
E
V
L
Q
K
L
-
N
-
H
-
P
R
I
V
R
L
K
G
F
Y
E
D
T
E
S
----
Y
Y
M
V
M
E
F
V
S
G
G
D
L
-
M
D
F
V
A
A
--
H
G
----
A
---
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
-
I
L
-
I
E
Q
--
D
D
P
V
L
V
K
I
T
D
F
G
L
-----------------------------
T
--
F
C
G
T
L
A
Y
V
A
P
E
V
I
-------------
R
N
---
E
-----
Y
-
S
S
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
------
S
G
-
S
T
------
Q
D
Q
L
Y
K
Q
I
G
R
G
S
Y
H
-
E
G
P
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
R
S
T
A
A
K
A
L
N
H
P
W
I
-------------
V
----------------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
61.19
35%
-3
- C1 -
-
4IHP
1
?
A:
[49-383]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKEQISVP--
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
90
Blastp_CBE
61.14
38%
8
- C1 -
-
2W4K
1
DAPK1_HUMAN
A:
[13-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
D
T
Q
Q
----------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
61.11
39%
2
- C1 -
-
1PHK
1
PHKG1_RABIT
A:
[15-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
E
N
-
Y
E
P
-
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
VT
G
G
G
-------
S
-------
F
----
S
A
--
E
-----
E
----
V
----
Q
E
LREATL
K
E
V
D
I
L
R
K
V
-
S
G
H
-
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
----
F
F
L
V
F
D
L
M
K
K
G
E
L
-
F
D
Y
L
T
E
--
K
V
----
T
---
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
-
I
L
-
L
----
D
D
D
M
N
I
K
L
T
D
F
G
F
S
--
C
--
Q
-----
L
--
D
PG-
E
---
K
---
L
R
E
--
V
C
G
T
P
S
Y
L
A
P
E
I
I
------
E
CSMNDN
H
P
---
G
-----
Y
-
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
------
W
H
-
R
K
--
Q
M
--
L
--
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
-
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
-------------
Q
Q
Y
V
-------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
61.09
37%
4
- C1 -
-
3HZT
9
?
A:
[3-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
R
-
Y
Q
R
-
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
K
--
K
S
S
-------
V
-------
T
----
T
T
--
S
-----
N
SG--
A
----
L
L
------
D
E
V
A
V
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
----
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
-
F
D
E
I
I
L
--
R
Q
----
K
---
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
R
D
A
L
I
K
I
V
D
F
G
L
S
--
A
--
H
-----
F
--
E
V-----------------
G
T
A
Y
Y
I
A
P
E
V
L
------
R
------
K
K
---------
Y
-
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
------
G
G
-
Q
T
--
D
----
Q
E
I
L
K
R
V
E
K
G
K
F
S
F
D
P
P
D
W
T
-
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
A
E
E
A
L
N
H
P
W
I
-------------
V
K
F
C
S
Q
K
H
---------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
61.01
39%
-38
- C1 -
-
3NCG
1
?
A:
[19-323]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
A
E
R
-
Y
N
I
-
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
--
K
A
S
-------
A
-------
K
----
N
K
--
D
T----
S
----
T
----
I
L
------
R
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
----
F
Y
I
V
G
E
L
Y
T
G
G
E
L
-
F
D
E
I
I
K
--
R
K
----
R
---
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
-
I
L
-
L
-
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
--
T
--
C
-----
F
--
Q
---
Q
NT-----------
I
G
T
A
Y
Y
I
A
P
E
V
L
------
R
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
------
Y
G
-
K
N
------
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
-
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
-------------
Q
K
Y
S
S
E
-----------------------------------------------------------------------------------------------------------------
175
Blastp_CBE
61.00
37%
7
- C1 -
-
2CKE
1
DAPK2_HUMAN
C:
[14-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
-
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
--
K
R
Q
-------
S
RASRRG-
V
----
S
R
--
E
-----
E
---------
I
E
------
R
E
V
S
I
L
R
Q
V
-
L
-
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
Q
--
K
E
----
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
--
H
--
E
-----
I
--
E
---
D
GV-
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
-
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
-------------
T
P
V
D
N
Q
Q
A
M
V
R
R
E
----------------------------------------------------------------------------------------------------------
96
Blastp_CBE
60.93
38%
-26
- C1 -
-
4CZU
3
CIPKN_ARATH
A:
[8-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
V
G
K
-
Y
E
L
-
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
--
K
E
K
-------
V
-------
L
----
K
N
--
K
-----
M
----
I
AQ--
I
K
------
R
E
I
S
T
M
K
L
I
-
K
-
H
-
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
----
I
Y
F
V
L
E
F
V
T
G
G
E
L
-
F
D
K
I
S
S
--
N
G
----
R
---
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
-
L
L
-
L
----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
--
A
--
L
PQQVR
E
--
D
---
G
---
L
---
L
H
D
--
T
C
G
T
P
N
Y
V
A
P
E
V
I
------
N
------
N
K
---
G
-----
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
------
E
D
-
S
N
------
L
T
S
L
Y
K
K
I
F
--
K
A
E
F
T
C
P
P
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
-------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
60.89
39%
-29
- C1 -
-
4CZT
3
CIPKN_ARATH
C:
[10-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
K
-
Y
E
L
-
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
--
K
E
K
-------
V
-------
L
----
K
N
--
K
-----
M
----
I
AQ--
I
K
------
R
E
I
S
T
M
K
L
I
-
K
-
H
-
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
----
I
Y
F
V
L
E
F
V
T
G
G
E
L
-
F
D
K
I
S
S
--
N
G
----
R
---
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
-
L
L
-
L
----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
--
A
--
L
PQQVR
E
--
D
---
G
---
L
---
L
H
T
--
T
C
G
T
P
N
Y
V
A
P
E
V
I
------
N
------
N
K
---
G
-----
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
------
E
D
-
S
N
------
L
T
S
L
Y
K
K
I
F
--
K
A
E
F
T
C
P
P
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
-------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
60.87
37%
10
- C1 -
-
2Y0A
1
DAPK1_HUMAN
A:
[13-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
------
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
D
T
Q
Q
----------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
60.73
39%
-25
- C1 -
-
4CZT
3
CIPKN_ARATH
A:
[8-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
V
G
K
-
Y
E
L
-
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
--
K
E
K
-------
V
-------
L
----
K
N
--
K
-----
M
----
I
AQ--
I
K
------
R
E
I
S
T
M
K
L
I
-
K
-
H
-
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
----
I
Y
F
V
L
E
F
V
T
G
G
E
L
-
F
D
K
I
S
S
--
N
G
----
R
---
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
-
L
L
-
L
----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
--
A
--
L
PQQVR
E
--
D
---
G
---
L
---
L
H
T
--
T
C
G
T
P
N
Y
V
A
P
E
V
I
------
N
------
N
K
---
G
-----
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
------
E
D
-
S
N
------
L
T
S
L
Y
K
K
I
F
--
K
A
E
F
T
C
P
P
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
-------------------------------------------------------------------------------------------------------------------------------------
177
Blastp_CBE
60.70
37%
3
- C1 -
-
2CKE
1
DAPK2_HUMAN
A:
[14-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
-
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
--
K
R
Q
-------
S
RASRRG-
V
----
S
R
--
E
-----
E
---------
I
E
------
R
E
V
S
I
L
R
Q
V
-
L
-
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
Q
--
K
E
----
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
--
H
--
E
-----
I
--
E
---
D
GV-
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
-
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
-------------
T
P
V
D
N
Q
Q
A
M
V
R
R
E
----------------------------------------------------------------------------------------------------------
74
Blastp_CBE
60.69
36%
2
- C1 -
-
3BQR
4
DAPK3_HUMAN
A:
[1-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
V
E
D
H
-
Y
E
M
-
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
--
K
R
R
-------
L
-------
S
----
S
S
--
R
RGVSR
E
----
E
----
I
E
------
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
--
K
-----
I
--
E
---
A
GN-------
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
E
T
------
K
Q
E
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
-------------
K
--
A
I
R
R
R
N
V
R
------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
60.65
37%
-124
- C1 -
-
5TX3
2
MELK_HUMAN
B:
[11-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
-
Y
E
L
-
H
E
T
I
G
-----
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
--
K
-------------------------------------------
K
------
T
E
I
E
A
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
-
F
D
Y
I
I
S
--
Q
D
----
R
---
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
-
L
L
-
F
D
E
Y
----
H
K
L
K
L
I
D
-------------------------------------
G
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
-----------L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
--
V
M
--
A
--
L
Y
K
K
I
M
R
G
K
--
Y
D
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-------------
M
Q
D
--------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
60.57
37%
7
- C1 -
-
2CKE
1
DAPK2_HUMAN
D:
[14-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
-
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
--
K
R
Q
-------
S
RASRRG-
V
----
S
R
--
E
-----
E
---------
I
E
------
R
E
V
S
I
L
R
Q
V
-
L
-
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
Q
--
K
E
----
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
--
H
--
E
-----
I
--
E
---
D
GV-
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
-
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
-------------
T
P
V
D
N
Q
Q
A
M
V
R
R
E
----------------------------------------------------------------------------------------------------------
148
Blastp_CBE
60.42
37%
6
- C1 -
-
3GU6
1
DAPK1_HUMAN
A:
[13-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
------
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
D
T
Q
-----------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
60.42
40%
1
- C1 -
-
2PHK
2
PHKG1_RABIT
A:
[2-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
E
N
-
Y
E
P
-
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
VT
G
G
G
-------
S
-------
F
----
S
A
--
E
-----
E
----
V
----
Q
E
LREATL
K
E
V
D
I
L
R
K
V
-
S
G
H
-
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
----
F
F
L
V
F
D
L
M
K
K
G
E
L
-
F
D
Y
L
T
E
--
K
V
----
T
---
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
-
I
L
-
L
----
D
D
D
M
N
I
K
L
T
D
F
G
F
S
--
C
--
Q
-----
L
--
D
PG-
E
---
K
---
L
R
E
--
V
C
G
T
P
S
Y
L
A
P
E
I
I
------
E
CSMNDN
H
P
---
G
-----
Y
-
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
------
W
H
-
R
K
--
Q
M
--
L
--
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
-
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
-------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
60.36
40%
-14
- C1 -
-
2Y7J
1
PHKG2_HUMAN
B:
[94-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
-
Y
D
P
-
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V-
T
A
---------------------
S
P
--
E
-----
Q
----
L
----
E
E
VREATR
R
E
T
H
I
L
R
Q
V
-
A
G
H
-
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
----
M
F
L
V
F
D
L
M
R
K
G
E
L
-
F
D
Y
L
T
E
--
K
V
----
A
---
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
-
I
L
-
L
----
D
D
N
M
Q
I
R
L
S
D
F
G
F
S
--
C
--
H
-----
L
--
E
PG-
E
---
K
---
L
R
E
--
L
C
G
T
P
G
Y
L
A
P
E
I
L
KCSMDE
T
------
H
P
---
G
-----
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
------
W
H
-
R
R
--
Q
I
--
L
--
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
-
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
-------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
60.35
36%
-2
- C1 -
-
3BHY
1
DAPK3_HUMAN
A:
[2-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
E
D
H
-
Y
E
M
-
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
--
K
R
R
-------
L
-------
S
----
S
S
--
R
RGVSR
E
----
E
----
I
E
------
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
--
K
-----
I
--
E
-----------------
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
E
T
------
K
Q
E
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
-------------
K
--
A
I
R
R
R
N
V
-------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
60.34
35%
6
- C1 -
-
3T3U
5
?
A:
[26-363]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKEQISVDVP
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
238
Blastp_CBE
60.33
35%
5
- C1 -
-
4WG5
1
?
A:
[26-352]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKEQISVDVP
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
258
Blastp_CBE
60.28
35%
3
- C1 -
-
4MX9
1
?
A:
[27-359]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKEQISVDVP
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
257
Blastp_CBE
60.25
35%
6
- C1 -
-
4MXA
1
?
A:
[27-359]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKEQISVDVP
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
101
Blastp_CBE
60.23
38%
2
- C1 -
-
3EH9
1
DAPK1_HUMAN
A:
[12-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRG--
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
-----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
D
T
Q
-----------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
60.21
34%
-89
- C1 -
-
2XM8
1
CHK2_HUMAN
A:
[14-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
-----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
------------------------------------------
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
--
T
---
S
---
L
---
M
R
T
--
L
C
G
---
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
-------------------------------------------------------------------------------------
242
Blastp_CBE
60.17
35%
1
- C1 -
-
4ONA
1
?
A:
[26-352]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKEQISVDVP
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
73
Blastp_CBE
60.17
36%
-8
- C1 -
-
5A6N
4
DAPK3_HUMAN
A:
[2-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
E
D
H
-
Y
E
M
-
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
--
K
R
R
-------
L
-------
S
----
S
S
--
R
RGVSR
E
----
E
----
I
E
------
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
--
K
-----
I
--
E
---
A
GN-
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
E
T
------
K
Q
E
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
-------------
K
--
A
I
------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
60.15
38%
0
- C1 -
-
1WVY
1
DAPK1_HUMAN
A:
[13-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
------
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
60.15
38%
6
- C1 -
-
2YAK
1
DAPK1_HUMAN
A:
[13-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
--------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
60.10
37%
4
- C1 -
-
4TXC
7
DAPK1_HUMAN
A:
[32-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
------
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
---------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
60.09
38%
9
- C1 -
-
6QMO
7
DAPK1_HUMAN
A:
[16-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
D
T
Q
Q
----------------------------------------------------------------------------------------------------------------
113
Blastp_CBE
60.03
38%
7
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[15-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
D
T
Q
Q
----------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
60.02
37%
7
- C1 -
-
3GU4
1
DAPK1_HUMAN
A:
[13-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
------
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
D
T
Q
-----------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
60.01
39%
-22
- C1 -
-
4CZT
2
CIPKN_ARATH
B:
[8-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
V
G
K
-
Y
E
L
-
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
--
K
E
K
-------
V
-------
L
----
K
N
--
K
-----
M
----
I
AQ--
I
K
------
R
E
I
S
T
M
K
L
I
-
K
-
H
-
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
----
I
Y
F
V
L
E
F
V
T
G
G
E
L
-
F
D
K
I
S
S
--
N
G
----
R
---
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
-
L
L
-
L
----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
--
A
--
L
PQQVR
E
--
D
---
G
---
L
---
L
H
T
--
T
C
G
T
P
N
Y
V
A
P
E
V
I
------
N
------
N
K
---
G
-----
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
------
E
D
-
S
N
------
L
T
S
L
Y
K
K
I
F
--
K
A
E
F
T
C
P
P
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
-------------------------------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
60.01
39%
-27
- C1 -
-
4CZT
4
CIPKN_ARATH
D:
[8-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
V
G
K
-
Y
E
L
-
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
--
K
E
K
-------
V
-------
L
----
K
N
--
K
-----
M
----
I
AQ--
I
K
------
R
E
I
S
T
M
K
L
I
-
K
-
H
-
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
----
I
Y
F
V
L
E
F
V
T
G
G
E
L
-
F
D
K
I
S
S
--
N
G
----
R
---
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
-
L
L
-
L
----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
--
A
--
L
PQQVR
E
--
D
---
G
---
L
---
L
H
T
--
T
C
G
T
P
N
Y
V
A
P
E
V
I
------
N
------
N
K
---
G
-----
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
------
E
D
-
S
N
------
L
T
S
L
Y
K
K
I
F
--
K
A
E
F
T
C
P
P
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
-------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
59.96
36%
-5
- C1 -
-
5A6O
3
DAPK3_HUMAN
A:
[3-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
H
-
Y
E
M
-
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
--
K
R
R
-------
L
-------
S
----
S
S
--
R
RGVSR
E
----
E
----
I
E
------
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
--
K
-----
I
--
E
------------
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
E
T
------
K
Q
E
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
-------------
K
--
A
I
------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
59.94
38%
4
- C1 -
-
5AV3
1
DAPK1_HUMAN
A:
[13-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
-----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
---------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
59.91
35%
-25
- C1 -
-
2J4Z
4
AURKA_HUMAN
A:
[33-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
-
F
E
I
-
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
--
K
A
Q
-------
L
EK-----
A
----
G
V
--
E
-----
H
----
Q
----
L
R
------
R
E
V
E
I
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
-
Y
R
E
L
Q
K
--
L
S
----
K
---
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
-
L
----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
-----------
V
--
H
---
A
---
P
SSR
R
T
T
--
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
------
G
R
---
M
-----
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
---------
E
A
--
N
T
--
Y
Q
E
T
Y
K
R
I
--
S
R
V
E
F
T
F
P
--
D
-
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
-------------
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
59.89
38%
6
- C1 -
-
3DFC
1
DAPK1_HUMAN
B:
[13-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
K
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
D
T
Q
-----------------------------------------------------------------------------------------------------------------
95
Blastp_CBE
59.88
38%
-22
- C1 -
-
4CZU
3
CIPKN_ARATH
B:
[8-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
V
G
K
-
Y
E
L
-
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
--
K
E
K
-------
V
-------
L
----
K
N
--
K
-----
M
----
I
AQ--
I
K
------
R
E
I
S
T
M
K
L
I
-
K
-
H
-
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
----
I
Y
F
V
L
E
F
V
T
G
G
E
L
-
F
D
K
I
S
S
--
N
G
----
R
---
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
-
L
L
-
L
----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
--
A
--
L
PQQVR
E
--
D
---
G
---
L
---
L
H
D
--
T
C
G
T
P
N
Y
V
A
P
E
V
I
------
N
------
N
K
---
G
-----
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
------
E
D
-
S
N
------
L
T
S
L
Y
K
K
I
F
--
K
A
E
F
T
C
P
P
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
-------------------------------------------------------------------------------------------------------------------------------------
100
Blastp_CBE
59.86
38%
5
- C1 -
-
3EHA
1
DAPK1_HUMAN
A:
[12-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
-----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
D
T
Q
-----------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
59.84
36%
-0
- C1 -
-
5VJA
2
DAPK3_HUMAN
C:
[1-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
V
E
D
H
-
Y
E
M
-
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
--
K
R
R
-------
L
-------
S
----
S
----GVSR-
E
----
E
----
I
E
------
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
--
E
--
K
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
--
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
--
K
-----
I
--
E
---
A
GN-
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
E
T
------
K
Q
E
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
-------------
K
--
A
I
------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
59.80
35%
3
- C1 -
-
4M84
1
?
A:
[26-352]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKEQISVDVP
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
231
Blastp_CBE
59.80
35%
5
- C1 -
-
6BFA
1
?
A:
[26-352]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKEQISVDVP
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
104
Blastp_CBE
59.71
38%
10
- C1 -
-
1IG1
1
DAPK1_HUMAN
A:
[12-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
D
T
Q
-----------------------------------------------------------------------------------------------------------------
97
Blastp_CBE
59.68
38%
12
- C1 -
-
4YPD
1
DAPK1_HUMAN
A:
[12-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
D
T
Q
Q
----------------------------------------------------------------------------------------------------------------
94
Blastp_CBE
59.64
38%
-26
- C1 -
-
4CZU
3
CIPKN_ARATH
C:
[9-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
G
K
-
Y
E
L
-
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
--
K
E
K
-------
V
-------
L
----
K
N
--
K
-----
M
----
I
AQ--
I
K
------
R
E
I
S
T
M
K
L
I
-
K
-
H
-
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
----
I
Y
F
V
L
E
F
V
T
G
G
E
L
-
F
D
K
I
S
S
--
N
G
----
R
---
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
-
L
L
-
L
----
D
A
N
G
A
L
K
V
S
D
F
G
L
S
--
A
--
L
PQQVR
E
--
D
---
G
---
L
---
L
H
D
--
T
C
G
T
P
N
Y
V
A
P
E
V
I
------
N
------
N
K
---
G
-----
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
------
E
D
-
S
N
------
L
T
S
L
Y
K
K
I
F
--
K
A
E
F
T
C
P
P
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
-------------------------------------------------------------------------------------------------------------------------------------
98
Blastp_CBE
59.63
38%
8
- C1 -
-
4YO4
1
DAPK1_HUMAN
A:
[12-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
-
T
Q
Q
----------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
59.61
35%
5
- C1 -
-
3I7B
4
?
A:
[26-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQK----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
QTYTKEQISVDVP
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
AALL
Y
M
G
S
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
N
G
D
G
Q
L
-----------------------------------------------------------------
206
Blastp_CBE
59.61
34%
-81
- C1 -
-
2CN8
1
CHK2_HUMAN
A:
[14-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
-------------------------------------
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
--
T
---
S
---
L
---
M
R
T
--
L
C
--
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
-------
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
-------------------------------------------------------------------------------------
69
Blastp_CBE
59.59
36%
7
- C1 -
-
5VJA
2
DAPK3_HUMAN
A:
[1-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
V
E
D
H
-
Y
E
M
-
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
--
K
R
-------------------------
R
RGVSR
E
----
E
----
I
E
------
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
--
K
-----
I
--
E
---
A
GN-
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
E
T
------
K
Q
E
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
-------------
K
--
A
-------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
59.58
38%
-21
- C1 -
-
4YZB
1
?
A:
[30-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
S
--
K
R
---------------------
Q
K
TD
K
-----
E
----
L
----
L
L
------
K
E
V
E
L
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
T
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
N
K
R
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
S
TK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
--
E
F
----
D
I
L
K
K
V
E
K
G
K
F
T
F
D
L
P
Q
W
K
-
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
S
A
R
D
A
L
E
H
E
W
L
------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
59.57
38%
-0
- C1 -
-
4PF4
6
DAPK1_HUMAN
A:
[14-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
------
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
59.49
38%
8
- C1 -
-
4UV0
1
DAPK1_HUMAN
A:
[15-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
D
T
Q
Q
----------------------------------------------------------------------------------------------------------------
99
Blastp_CBE
59.47
38%
6
- C1 -
-
3F5G
1
DAPK1_HUMAN
A:
[12-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
-----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
D
T
Q
-----------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
59.43
38%
1
- C1 -
-
2W4J
1
DAPK1_HUMAN
A:
[13-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
------
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
59.42
36%
-39
- C1 -
-
5ES1
1
MARK4_HUMAN
A:
[12-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
H
V
G
N
-
Y
R
L
-
L
R
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
--
K
T
Q
-------
L
-------
N
P---
S
S
--
L
-----
Q
----
K
----
L
F
------
R
E
V
R
I
M
K
G
L
-
N
-
H
-
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
----
L
Y
L
V
M
E
Y
A
S
A
G
E
V
-
F
D
Y
L
V
S
--
H
G
----
R
---
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
K
N
I
V
H
R
D
L
K
A
E
N
-
L
L
-
L
----
D
A
E
A
N
I
K
I
A
D
F
G
F
S
--
N
-------------------------------
S
P
P
Y
A
A
P
E
L
F
------
Q
------
G
K
---
K
-----
Y
D
G
P
E
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
------
D
G
--
H
--
N
L
--
K
E
-
L
R
E
R
V
L
R
G
K
--
Y
R
V
P
F
Y
---
M
S
T
D
C
E
S
I
L
R
R
F
L
V
L
N
P
A
K
R
C
T
L
E
Q
I
M
K
D
K
W
I
-------------
N
----------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
59.31
38%
5
- C1 -
-
6QN4
4
DAPK1_HUMAN
A:
[16-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
---------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
59.30
38%
6
- C1 -
-
5AUX
1
DAPK1_HUMAN
A:
[13-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
-----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
---------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
59.25
37%
6
- C1 -
-
3GU7
1
DAPK1_HUMAN
A:
[13-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
------
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
D
T
Q
-----------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
59.21
36%
1
- C1 -
-
5A6O
2
DAPK3_HUMAN
B:
[1-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
V
E
D
H
-
Y
E
M
-
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
--
K
R
R
-------
L
-------
S
----
S
S
--
R
RGVSR
E
----
E
----
I
E
------
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
--
K
-----
I
--
E
------------
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
E
T
------
K
Q
E
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
-------------
K
--
A
-------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
59.18
38%
-52
- C1 -
-
4D9U
1
A:
[24-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
-
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
--
K
S
K
-------
R
-------
D
----
P
T
--
E
------------------------
E
I
E
I
L
L
R
Y
G
Q
-
H
-
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
----
V
Y
V
V
T
E
L
M
K
G
G
E
L
-
L
D
K
I
L
R
--
Q
K
----
F
---
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
-
I
L
-
Y
V
D
E
S
G
N
P
E
S
I
R
I
C
D
F
G
F
A
--
K
--
Q
-----
L
--
R
AEN
G
---
L
---
L
M
T
--
P
C
Y
T
A
N
F
V
A
P
E
V
L
------
E
------
R
Q
---
G
-----
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
------
A
N
G
P
D
--
D
T
--
P
E
E
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
-
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------
323
Blastp_CBE
59.12
35%
-6
- C1 -
-
2J4Z
2
AURKA_HUMAN
B:
[33-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
-
F
E
I
-
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
--
K
A
Q
-------
L
EK-----
A
----
G
V
--
E
-----
H
----
Q
----
L
R
------
R
E
V
E
I
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
-
Y
R
E
L
Q
K
--
L
S
----
K
---
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
-
L
----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
-----------
V
--
H
---
A
---
P
SSR
R
T
T
--
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
------
G
R
---
M
-----
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
---------
E
A
--
N
T
--
Y
Q
E
T
Y
K
R
I
--
S
R
V
E
F
T
F
P
--
D
-
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
-------------
T
A
N
S
S
K
P
S
N
C
Q
------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
59.12
37%
6
- C1 -
-
3GU5
1
DAPK1_HUMAN
A:
[13-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
------
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
D
T
Q
-----------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
59.09
36%
-10
- C1 -
-
5VJA
3
DAPK3_HUMAN
D:
[1-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
V
E
D
H
-
Y
E
M
-
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
--
K
R
R
-------
L
-------
S
---------VSR--
E
----
E
----
I
E
------
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
---
E
--
K
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
--
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
--
K
-----
I
--
E
---
A
GN-
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
E
T
------
K
Q
E
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
-------------
K
--
A
-------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
59.03
38%
4
- C1 -
-
5AV0
1
DAPK1_HUMAN
A:
[13-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
-----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
---------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
59.03
38%
-49
- C1 -
-
4JG8
1
A:
[37-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
-
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
--
K
S
K
-------
R
-------
D
----
P
T
--
E
------------------------
E
I
E
I
L
L
R
Y
G
Q
-
H
-
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
----
V
Y
V
V
M
E
L
M
K
G
G
E
L
-
L
D
K
I
L
R
--
Q
K
----
F
---
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
-
I
L
-
Y
V
D
E
S
G
N
P
E
S
I
R
I
C
D
F
G
F
A
--
K
--
Q
-----
L
--
R
AEN
G
---
L
---
L
M
T
--
P
C
Y
T
A
N
F
V
A
P
E
V
L
------
E
------
R
Q
---
G
-----
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
------
A
N
G
P
D
--
D
T
--
P
E
E
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
-
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
58.96
38%
10
- C1 -
-
1JKL
1
DAPK1_HUMAN
A:
[12-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
D
T
Q
-----------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
58.93
38%
5
- C1 -
-
2XUU
1
DAPK1_HUMAN
A:
[13-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
A
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
D
T
Q
Q
----------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
58.87
38%
3
- C1 -
-
5AUY
1
DAPK1_HUMAN
A:
[13-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
-----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
---------------------------------------------------------------------------------------------------------------------
473
Blastp_CBE
58.86
36%
-60
- C1 -
-
6CJ5
1
MKNK2_HUMAN
A:
[20-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
--
K
Q
P
-------
G
-------
H
----
I
R
--
S
-----
R
----
V
----
F
-------
R
E
V
E
M
L
Y
Q
C
-
Q
G
H
-
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
----
F
Y
L
V
F
E
K
M
R
G
G
S
I
-
L
S
H
I
H
K
--
R
R
----
H
---
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
-
I
L
--
C
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
-----------------------------------
G
S
A
E
Y
M
A
P
E
V
V
------
E
------
A
F
---
S
EEASI
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG----
A
CP
A
C
--
Q
N
M
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
-
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
58.84
38%
-49
- C1 -
-
4D9T
1
A:
[24-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
-
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
--
K
S
K
-------
R
-------
D
----
P
T
--
E
------------------------
E
I
E
I
L
L
R
Y
G
Q
-
H
-
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
----
V
Y
V
V
T
E
L
M
K
G
G
E
L
-
L
D
K
I
L
R
--
Q
K
----
F
---
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
-
I
L
-
Y
V
D
E
S
G
N
P
E
S
I
R
I
C
D
F
G
F
A
--
K
--
Q
-----
L
--
R
AEN
G
---
L
---
L
M
T
--
P
C
Y
T
A
N
F
V
A
P
E
V
L
------
E
------
R
Q
---
G
-----
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
------
A
N
G
P
D
--
D
T
--
P
E
E
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
-
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
58.83
34%
-36
- C1 -
-
4BDB
10
CHK2_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
---------------------------------L---
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
E-
T
---
S
---
L
---
M
R
T
--
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
E
S
T
----------------------------------------------------------------------------------
72
Blastp_CBE
58.83
36%
1
- C1 -
-
5A6N
1
DAPK3_HUMAN
B:
[1-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
V
E
D
H
-
Y
E
M
-
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
--
K
R
R
-------
L
-------
S
----
S
S
--
R
RGVSR
E
----
E
----
I
E
------
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
--
K
-----
I
--
E
------------
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
E
T
------
K
Q
E
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
-------------
K
--
A
I
------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
58.68
34%
-20
- C1 -
-
2WTC
1
CHK2_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
---------------------------------PAL-
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
--
T
---
S
---
L
---
M
R
T
--
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
E
S
T
----------------------------------------------------------------------------------
131
Blastp_CBE
58.67
38%
4
- C1 -
-
5AUV
1
DAPK1_HUMAN
A:
[13-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
-----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
---------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
58.65
34%
-15
- C1 -
-
2WTD
4
CHK2_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
---------------------------------PAL-
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
--
T
---
S
---
L
---
M
R
T
--
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
E
S
T
----------------------------------------------------------------------------------
124
Blastp_CBE
58.58
38%
5
- C1 -
-
5AV2
1
DAPK1_HUMAN
A:
[13-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
-----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
---------------------------------------------------------------------------------------------------------------------
103
Blastp_CBE
58.58
38%
8
- C1 -
-
1JKK
1
DAPK1_HUMAN
A:
[12-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
--------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
58.49
36%
-49
- C1 -
-
2HW7
1
MKNK2_HUMAN
A:
[20-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
--
K
Q
P
-------
G
-------
H
----
I
R
--
S
-----
R
----
V
----
F
-------
R
E
V
E
M
L
Y
Q
C
-
Q
G
H
-
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
----
F
Y
L
V
F
E
K
M
R
G
G
S
I
-
L
S
H
I
H
K
--
R
R
----
H
---
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
-
I
L
--
C
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
-----------------------------------
G
S
A
E
Y
M
A
P
E
V
V
------
E
------
A
F
---
S
EEASI
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG----
A
CP
A
C
--
Q
N
M
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
-
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
58.48
38%
7
- C1 -
-
5AUT
1
DAPK1_HUMAN
A:
[13-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
----
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
---------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
58.46
38%
-52
- C1 -
-
4JG7
1
A:
[37-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
-
K
E
D
I
G
V
--
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
--
K
S
K
-------
R
-------
D
----
P
T
--
E
------------------------
E
I
E
I
L
L
R
Y
G
Q
-
H
-
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
----
V
Y
V
V
T
E
L
M
K
G
G
E
L
-
L
D
K
I
L
R
--
Q
K
----
F
---
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
-
I
L
-
Y
V
D
E
S
G
N
P
E
S
I
R
I
C
D
F
G
F
A
--
K
--
Q
-----
L
--
R
AEN
G
---
L
---
L
M
T
--
P
C
Y
T
A
N
F
V
A
P
E
V
L
------
E
------
R
Q
---
G
-----
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
------
A
N
G
P
D
--
D
T
--
P
E
E
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
-
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------
203
Blastp_CBE
58.43
34%
-22
- C1 -
-
2WTI
3
CHK2_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
---------------------------------PAL-
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
E-
T
---
S
---
L
---
M
R
T
--
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
E
S
T
----------------------------------------------------------------------------------
48
Blastp_CBE
58.33
38%
-49
- C1 -
-
4MAO
1
A:
[37-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
-
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
--
K
S
K
-------
R
-------
D
----
P
T
--
E
------------------------
E
I
E
I
L
L
R
Y
G
Q
-
H
-
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
----
V
Y
V
V
M
E
L
M
K
G
G
E
L
-
L
D
K
I
L
R
--
Q
K
----
F
---
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
-
I
L
-
Y
V
D
E
S
G
N
P
E
S
I
R
I
C
D
F
G
F
A
--
K
--
Q
-----
L
--
R
AEN
G
---
L
---
L
M
T
--
P
C
Y
T
A
N
F
V
A
P
E
V
L
------
E
------
R
Q
---
G
-----
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
------
A
N
G
P
D
--
D
T
--
P
E
E
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
-
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------
197
Blastp_CBE
58.27
34%
-16
- C1 -
-
4A9S
1
CHK2_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
---------------------------------PAL-
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
--
T
---
S
---
L
---
M
R
T
--
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
E
S
T
----------------------------------------------------------------------------------
122
Blastp_CBE
58.21
38%
3
- C1 -
-
5AV4
1
DAPK1_HUMAN
A:
[13-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
----
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
---------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
58.16
38%
-51
- C1 -
-
4M8T
1
A:
[37-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
-
K
E
D
I
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
--
K
S
K
-------
R
-------
D
----
P
T
--
E
------------------------
E
I
E
I
L
L
R
Y
G
Q
-
H
-
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
----
V
Y
V
V
M
E
L
M
K
G
G
E
L
-
L
D
K
I
L
R
--
Q
K
----
F
---
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
-
I
L
-
Y
V
D
E
S
G
N
P
E
S
I
R
I
C
D
F
G
F
A
--
K
--
Q
-----
L
--
R
AEN
G
---
L
---
L
M
T
--
P
C
Y
T
A
N
F
V
A
P
E
V
L
------
E
------
R
Q
---
G
-----
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
------
A
N
G
P
D
--
D
T
--
P
E
E
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
-
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
58.10
36%
-62
- C1 -
-
6CJH
1
MKNK2_HUMAN
A:
[20-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
--
K
Q
P
-------
G
-------
H
----
I
R
--
S
-----
R
----
V
----
F
-------
R
E
V
E
M
L
Y
Q
C
-
Q
G
H
-
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
----
F
Y
L
V
F
E
K
M
R
G
G
S
I
-
L
S
H
I
H
K
--
R
R
----
H
---
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
-
I
L
--
C
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
-----------------------------------
G
S
A
E
Y
M
A
P
E
V
V
------
E
------
A
F
---
S
EEASI
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG----
A
CP
A
C
--
Q
N
M
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
-
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
------------------------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
57.92
34%
-11
- C1 -
-
4A9R
2
CHK2_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
---------------------------------PAL-
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
GE
T
---
S
---
L
---
M
R
T
--
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
E
S
T
----------------------------------------------------------------------------------
472
Blastp_CBE
57.91
36%
-63
- C1 -
-
6CJE
1
MKNK2_HUMAN
A:
[20-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
--
K
Q
P
-------
G
-------
H
----
I
R
--
S
-----
R
----
V
----
F
-------
R
E
V
E
M
L
Y
Q
C
-
Q
G
H
-
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
----
F
Y
L
V
F
E
K
M
R
G
G
S
I
-
L
S
H
I
H
K
--
R
R
----
H
---
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
-
I
L
--
C
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
---------------------------------
P
C
G
S
A
E
Y
M
A
P
E
V
V
------
E
------
A
F
---
S
EEASI
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG----
A
CP
A
C
--
Q
N
M
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
-
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
57.86
38%
4
- C1 -
-
5AUW
1
DAPK1_HUMAN
A:
[13-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
---------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
---------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
57.83
38%
9
- C1 -
-
3GU8
1
DAPK1_HUMAN
A:
[13-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
G
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
D
-------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
57.82
34%
-14
- C1 -
-
4A9T
4
CHK2_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
---------------------------------PAL-
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
GE
T
---
S
---
L
---
M
R
T
--
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
E
S
T
----------------------------------------------------------------------------------
127
Blastp_CBE
57.82
38%
5
- C1 -
-
5AUZ
1
DAPK1_HUMAN
A:
[13-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
----
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
---------------------------------------------------------------------------------------------------------------------
202
Blastp_CBE
57.77
34%
-21
- C1 -
-
2WTJ
5
CHK2_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
---------------------------------PAL-
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
E-
T
---
S
---
L
---
M
R
T
--
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
E
S
T
----------------------------------------------------------------------------------
199
Blastp_CBE
57.72
34%
-12
- C1 -
-
2XM9
1
CHK2_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
---------------------------------PAL-
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
GE
T
---
S
---
L
---
M
R
T
--
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
E
S
T
----------------------------------------------------------------------------------
114
Blastp_CBE
57.58
38%
6
- C1 -
-
3F5U
1
DAPK1_HUMAN
A:
[13-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
D
T
Q
-----------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
57.57
34%
-3
- C1 -
-
4BDK
4
CHK2_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
---------------------------------AL--
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
GE
T
---
S
---
L
---
M
R
T
--
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
E
S
T
----------------------------------------------------------------------------------
153
Blastp_CBE
57.48
38%
6
- C1 -
-
3GUB
1
DAPK1_HUMAN
A:
[13-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
G
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
D
-------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
57.13
36%
-53
- C1 -
-
6CKI
1
MKNK2_HUMAN
A:
[20-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
--
K
Q
P
-------
G
-------
H
----
I
R
--
S
-----
R
----
V
----
F
-------
R
E
V
E
M
L
Y
Q
C
-
Q
G
H
-
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
----
F
Y
L
V
F
E
K
M
R
G
G
S
I
-
L
S
H
I
H
K
--
R
R
----
H
---
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
-
I
L
--
C
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
-----------------------------------
G
S
A
E
Y
M
A
P
E
V
V
------
E
------
A
F
---
S
EEASI
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG----
A
CP
A
C
--
Q
N
M
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
-
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
------------------------------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
57.04
36%
-47
- C1 -
-
6CK3
1
MKNK2_HUMAN
A:
[20-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
--
K
Q
P
-------
G
-------
H
----
I
R
--
S
-----
R
----
V
----
F
-------
R
E
V
E
M
L
Y
Q
C
-
Q
G
H
-
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
----
F
Y
L
V
F
E
K
M
R
G
G
S
I
-
L
S
H
I
H
K
--
R
R
----
H
---
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
-
I
L
--
C
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
-----------------------------------
G
S
A
E
Y
M
A
P
E
V
V
------
E
------
A
F
---
S
EEASI
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG----
A
CP
A
C
--
Q
N
M
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
-
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
------------------------------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
57.02
36%
-53
- C1 -
-
6CJY
1
MKNK2_HUMAN
A:
[20-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
--
K
Q
P
-------
G
-------
H
----
I
R
--
S
-----
R
----
V
----
F
-------
R
E
V
E
M
L
Y
Q
C
-
Q
G
H
-
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
----
F
Y
L
V
F
E
K
M
R
G
G
S
I
-
L
S
H
I
H
K
--
R
R
----
H
---
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
-
I
L
--
C
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
-----------------------------------
G
S
A
E
Y
M
A
P
E
V
V
------
E
------
A
F
---
S
EEASI
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG----
A
CP
A
C
--
Q
N
M
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
-
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
------------------------------------------------------------------------------------------------------------------------------------
56
Blastp_CBE
57.02
38%
-51
- C1 -
-
4JG6
1
A:
[37-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
-
K
E
D
I
-----
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
--
K
S
K
-------
R
-------
D
----
P
T
--
E
------------------------
E
I
E
I
L
L
R
Y
G
Q
-
H
-
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
----
V
Y
V
V
T
E
L
M
K
G
G
E
L
-
L
D
K
I
L
R
--
Q
K
----
F
---
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
-
I
L
-
Y
V
D
E
S
G
N
P
E
S
I
R
I
C
D
F
G
F
A
--
K
--
Q
-----
L
--
R
AEN
G
---
L
---
L
M
T
--
P
C
Y
T
A
N
F
V
A
P
E
V
L
------
E
------
R
Q
---
G
-----
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
------
A
N
G
P
D
--
D
T
--
P
E
E
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
-
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
57.01
38%
5
- C1 -
-
5AUU
1
DAPK1_HUMAN
A:
[13-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
----
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
---------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
56.97
34%
-10
- C1 -
-
2XBJ
1
CHK2_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
---------------------------------AL--
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
--
T
---
S
---
L
---
M
R
T
--
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
E
S
T
----------------------------------------------------------------------------------
190
Blastp_CBE
56.91
34%
-15
- C1 -
-
4BDE
5
CHK2_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
---------------------------------AL--
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
--
T
---
S
---
L
---
M
R
T
--
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
E
S
T
----------------------------------------------------------------------------------
416
Blastp_CBE
56.81
36%
-112
- C1 -
-
4PDS
1
RAD53_YEAST
B:
[26-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
D
E
V
V
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
S
V
K
I
I
----------------------------------------------
V
T
------
R
E
L
E
V
L
Q
K
L
-
N
-
H
-
P
R
I
V
R
L
K
G
F
Y
---------
Y
Y
M
V
M
E
F
V
S
G
G
D
L
-
M
D
F
V
A
A
--
H
G
----
A
---
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
-
I
L
-
I
E
Q
--
D
D
P
V
L
V
K
I
T
A
F
G
L
A
--
K
--------
V
----------------------
T
L
A
Y
V
A
P
E
V
I
--------------
N
---
E
-----
Y
-
S
S
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
---------
S
G
--
S
T
--
Q
D
Q
L
Y
K
Q
I
G
R
G
S
Y
H
-
E
G
P
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
R
S
T
A
A
K
A
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------
467
Blastp_CBE
56.80
36%
-55
- C1 -
-
6CK6
1
MKNK2_HUMAN
A:
[20-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
--
K
Q
P
-------
G
-------
H
----
I
R
--
S
-----
R
----
V
----
F
-------
R
E
V
E
M
L
Y
Q
C
-
Q
G
H
-
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
----
F
Y
L
V
F
E
K
M
R
G
G
S
I
-
L
S
H
I
H
K
--
R
R
----
H
---
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
-
I
L
--
C
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
-----------------------------------
G
S
A
E
Y
M
A
P
E
V
V
------
E
------
A
F
---
S
EEASI
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG----
A
CP
A
C
--
Q
N
M
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
-
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
------------------------------------------------------------------------------------------------------------------------------------
159
Blastp_CBE
56.60
38%
-16
- C1 -
-
3MA6
1
?
B:
[32-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
-
Y
K
G
-
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
--
K
R
Q
-------
V
KQ-----
T
----
D
K
--
E
-----
S
----
L
----
L
-------
R
E
V
Q
L
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
--
R
K
----
R
---
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
-
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--
T
--
H
-----
F
--
E
---
A
SK-
K
---
M
K
D
--
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
T
---------
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
G
-
A
N
------
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
-------------
Q
----------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
56.44
38%
-52
- C1 -
-
5O1S
2
A:
[46-303]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
-
K
E
D
I
-----
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
--
K
S
K
-------
R
-------
D
----
P
T
--
E
------------------------
E
I
E
I
L
L
R
Y
G
Q
-
H
-
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
----
V
Y
V
V
T
E
L
M
K
G
G
E
L
-
L
D
K
I
L
R
--
Q
K
----
F
---
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
-
I
L
-
Y
V
D
E
S
G
N
P
E
S
I
R
I
C
D
F
G
F
A
--
K
--
Q
-----
L
--
R
AEN
G
---
L
---
L
M
T
--
P
C
---
N
F
V
A
P
E
V
L
------
E
------
R
Q
---
G
-----
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
------
A
N
G
P
D
--
D
T
--
P
E
E
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
-
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
56.24
38%
10
- C1 -
-
6AAR
1
DAPK1_HUMAN
A:
[13-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
----------------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
---------------------------------------------------------------------------------------------------------------------
111
Blastp_CBE
55.96
37%
7
- C1 -
-
1P4F
1
DAPK1_HUMAN
A:
[12-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
----------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
--
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
FG-
N
---
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
------
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
P
K
D
-------------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
55.65
34%
0
- C1 -
-
4A9U
10
CHK2_HUMAN
A:
[14-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
E
-
Y
I
M
-
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
--
K
---------------------------------DPAL
N
----
V
E
------
T
E
I
E
I
L
K
K
L
-
N
-
H
-
P
C
I
I
K
-
I
K
N
F
F
D
A
E
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
--
N
K
----
R
---
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
-
V
L
-
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
--
K
--
I
-----
L
--
T
---
S
---
L
---
M
R
T
--
L
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
V
GTA
G
-----
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
-------
S
-
E
H
--
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-------------
Q
D
E
-------------
D
M
K
R
----
K
F
Q
D
L
L
S
E
E
N
E
S
T
----------------------------------------------------------------------------------
417
Blastp_CBE
55.34
36%
-89
- C1 -
-
4PDS
1
RAD53_YEAST
A:
[35-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
D
E
V
-------
T
V
K
K
A
I
E
R
T
T
G
K
T
F
S
V
K
I
I
----------------------------------------------
V
T
------
R
E
L
E
V
L
Q
K
L
-
N
-
H
-
P
R
I
V
R
L
K
G
F
Y
---
E
S
----
Y
Y
M
V
M
E
F
V
S
G
G
D
L
-
M
D
F
V
A
A
--
H
G
----
A
---
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
-
I
L
-
I
E
Q
--
D
D
P
V
L
V
K
I
T
A
F
G
L
A
--
K
--------
V
------------------------
A
Y
V
A
P
E
V
I
R------------
R
N
---
E
-----
Y
-
S
S
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
---------
S
G
--
S
T
--
Q
D
Q
L
Y
K
Q
I
G
R
G
S
Y
H
-
E
G
P
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
R
S
T
A
A
K
A
L
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
54.62
34%
-10
- C1 -
-
5LXM
6
AURKA_HUMAN
A:
[10-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
-
F
E
I
-
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
--
K
A
Q
-------
L
EK-----
A
----
G
V
--
E
-----
H
----
Q
----
L
R
------
R
E
V
E
I
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
----
V
Y
L
I
L
E
Y
A
P
L
G
T
V
-
Y
R
E
L
Q
K
--
L
S
----
K
---
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
-
L
----
G
S
A
G
E
L
K
I
A
D
F
G
W
S
--
V
--
H
-----
A
--
P
---
S
---
S
---
R
R
T
--
L
A
G
T
L
D
Y
L
P
P
E
M
I
------
E
------
G
R
---
M
-----
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
---------
E
A
--
N
T
--
Y
Q
E
T
Y
K
R
I
--
S
R
V
E
F
T
F
P
--
D
-
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
-------------
T
A
N
S
S
K
P
S
N
A
-------------------------------------------------------------------------------------------------------------
108
Blastp_CBE
53.48
38%
-10
- C1 -
-
3ZXT
1
DAPK1_HUMAN
B:
[13-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSRRG--
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
---------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
-------------------
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
-
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
----
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
----------------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
53.22
35%
-17
- C1 -
-
2JBO
1
MAPK2_HUMAN
A:
[17-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
N
A
I
I
D
D
-
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
--
D
-----------------
C
----
P
K
--
A
----------------
R
------
R
E
V
E
L
H
W
R
A
-
S
-
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
GRKC
L
L
I
V
M
E
C
L
D
G
G
E
L
-
F
S
R
I
Q
D
RG
D
Q
----
A
---
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
-
L
L
Y
T
S
K
R
P
N
A
I
--
L
K
L
T
D
F
G
F
A
KE
T
--
T
--------------------------
C
Y
T
P
Y
Y
V
A
P
E
V
L
------
G
------
P
E
---
K
-----
Y
-
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
------
Y
S
-
N
H
--
G
L
AI
S
P
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
-
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
52.85
38%
-6
- C1 -
-
3ZXT
1
DAPK1_HUMAN
C:
[13-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
-
G
E
E
L
--
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
--
K
R
R
-------
T
KSSRRG-
V
----
S
R
--
E
-----
D
---------
I
E
------
R
E
V
S
I
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
--
H
--
K
-----
I
--
D
--------------------
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
D
T
--
K
---
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-------------
K
----------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
45.14
36%
-0
- C1 -
-
2J90
2
DAPK3_HUMAN
A:
[21-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
V
E
D
H
-
Y
E
M
-
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
--
K
R
R
-------
L
-------
S
----
S
R
--
R
-----
G
----
V
SREE
I
E
------
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
E
--
K
E
----
S
---
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
--
K
-----
I
--
E
---
A
---------------
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
E
T
------
K
Q
E
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
I
A
-
Q
S
L
E
H
S
W
I
-------------
K
--
A
I
R
R
----------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
42.82
36%
-6
- C1 -
-
2J90
3
DAPK3_HUMAN
B:
[27-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-
Y
E
M
-
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
----
K
E
Y
A
A
K
F
I
K
--
K
R
R
-------
L
-------
S
----
S
R
--
R
-----
G
----
V
SREE
I
E
------
R
E
V
N
I
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
E
--
K
E
--------
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
-
I
M
-
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
--
H
--
K
-----
I
--
E
---
A
GN-
E
---
F
K
N
--
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
---
P
-----
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
G
-
E
T
------
K
Q
E
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
I
A
-
Q
S
L
E
H
S
W
I
-------------
K
--
A
I
R
R
R
N
--------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
42.68
34%
-47
- C1 -
-
5WVD
1
MKNK1_HUMAN
B:
[15-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
-
Y
K
L
T
S
E
L
L
G
E
G
A
Y
A
K
V
Q
G
A
V
S
L
Q
N
G
K
E
Y
A
V
K
I
I
E
--
K
Q
A
-------
G
-------
H
----
S
R
--
S
-----
R
----
V
----
F
R
------
E
V
E
T
L
Y
Q
C
Q
-
G
-
N
-
K
N
I
L
E
L
I
E
F
F
E
D
D
T
R
----
F
Y
L
V
F
E
K
L
Q
G
G
S
I
-
L
A
H
I
Q
------------------
A
S
R
V
V
R
D
V
A
A
A
L
D
F
L
H
T
K
G
I
A
H
R
D
L
K
P
E
N
-
I
L
--
C
E
S
P
--
V
S
P
V
K
I
C
D
F
D
L
G
--
S
GM-------------------------------
E
Y
M
A
P
E
V
V
EVFTD-
Q
------
A
T
---
F
-----
Y
-
D
K
R
C
D
L
W
S
L
G
V
V
L
Y
I
M
L
S
G
Y
P
------------------------------------------------
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
------------------------------------------------------------------------------------------------------------------------------------