@TOME V3
(Feb 2022)
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-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DYR1B_HUMAN: (2020-09-08 )
MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAASS
Atome Classification :
(362 SA)
.........10........20........30........40........50........60........70........80........90........100.......-.110.......120.......130-...-.-.-...140.---......150.......160....--...170---.........180---.------..----.....190.......200..--.....210.----......220.......230.......240.....---.--------.----250---------------.-------------------------.-.---------.---------.....260....--..--.270.---......280.....-.-.290........300.......310.------.....------.320.......330.....-..340-....-.--------..--350..---.-----...-----------.360.-..-..--.----.--..370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAVPPGHGPFSGFPG
P
Q
E
H
T
Q
VL
P
D
V
R
L
L
P
R
RL
P
L
A
FRDATSA
P
L
R
K
L
S
V
D
L
I
K
T
Y
K
H
I
N
E
V
Y
Y
A
K
K
K
RRAQQAPPQDSS
N
K
K
E
K
K
V
L
NHGYDDDNH
D
Y
I
V-R
S
G
E
R
W
L
-
E
R
Y
E
I
D
S
L
IGKGS
F
G
Q
V
V
K
A
YD-H-QT
Q
-
E
-
L
-
V
A
I
K
I
I
K---N
K
K
A
F
L
N
Q
A
Q
I
E
L
R
L
L
E
L
M
N
QHD--TEM
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
L
L
S
Y
N
L
Y
D
L
L
RNT--HFRGV
S
L
N
L
----
T
R
K
L
A
Q
Q
L
C
T
A
L
L
F
LATP
E
L
S
I
I
H
CDLKPE
N
I
L
L
---C--------N----P-----------------K-------------------------R-
S
---------
A
---------
I
K
I
V
DFGSS
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
FYRSP
E
V
L
LG-T-PY-
D
L
A
I
D
M
WS
L
G
C
I
L
V
E
MHTGEPLF------SGS
N
E
------
V
D
Q
M
N
R
I
V
E
V
LGIP
P
A
A
M
L-DQA
P
K
-
A
R
K
Y
-
F
--------
E
R--LPGGG---
W
-----
T
L
R
-----------
R
T
--
K
-
E
L
-
R
K
--D----Y--QGP
G
T
R
R
L
Q
E
V
LGVQTGGPGGRRAGEPGH
S
P
A
D
Y
L
R
F
Q
D
L
V
L
R
M
L
EYEPAARIS
P
L
G
A
L
Q
H
G
F
F
R
R
T
ADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN
R
T
Y
R
YSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPE
L
M
D
V
S
LVGGPADCSPPHPAPAPQH
P
A
A
S
A
L
R
T
RMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAASS
120
Blastp_CBE
97.50
83%
-142
- C1 -
-
6A1F
2
DYR1A_HUMAN
A:
[11-360]
-------------------------------------------------------------------------------------
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
T
--
K
--------
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
97.03
82%
-140
- C1 -
-
6EIL
1
DYR1A_HUMAN
A:
[12-358]
-------------------------------------------------------------------------------------
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
T
-----------
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
96.90
82%
-137
- C1 -
-
6EIS
1
DYR1A_HUMAN
A:
[12-358]
-------------------------------------------------------------------------------------
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
T
--
K
----
K
R
--
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
96.82
83%
-139
- C1 -
-
3ANQ
1
DYR1A_HUMAN
C:
[12-359]
-------------------------------------------------------------------------------------
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
------------------------
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
96.66
82%
-139
- C1 -
-
6EJ4
1
DYR1A_HUMAN
A:
[12-358]
-------------------------------------------------------------------------------------
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
T
--
K
-
D
------
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
96.66
82%
-141
- C1 -
-
5A3X
1
DYR1A_HUMAN
A:
[12-359]
-------------------------------------------------------------------------------------
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
T
-----------
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
556
HHSearch
96.59
83%
-137
- C1 -
-
4YU2
2
DYR1A_HUMAN
A:
[10-358]
-------------------------------------------------------------------------------------
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
T
--
K
-
D
G
-
K
R
--
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
Blastp_CBE
96.46
83%
-137
- C1 -
-
4YU2
2
DYR1A_HUMAN
A:
[10-358]
-------------------------------------------------------------------------------------
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
T
--
K
-
D
G
-
K
R
--
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
96.39
83%
-137
- C1 -
-
2VX3
2
DYR1A_HUMAN
D:
[32-377]
--------------------------------------------------------------------------------------
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
T
-------
K
R
--
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
96.17
83%
-137
- C1 -
-
4YLJ
3
DYR1A_HUMAN
A:
[11-357]
--------------------------------------------------------------------------------------
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
T
--
K
-
D
G
-
K
R
--
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
96.17
83%
-138
- C1 -
-
3ANR
1
DYR1A_HUMAN
B:
[11-359]
------------------------------------------------------------------------------------
R
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
T
----------------
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
96.13
82%
-137
- C1 -
-
6EIF
1
DYR1A_HUMAN
A:
[12-358]
-------------------------------------------------------------------------------------
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
T
--
K
-
D
------
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
96.07
83%
-138
- C1 -
-
4YLJ
5
DYR1A_HUMAN
B:
[10-357]
-------------------------------------------------------------------------------------
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
T
--
K
-
D
G
-
K
R
--
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
96.05
83%
-138
- C1 -
-
5AIK
1
DYR1A_HUMAN
C:
[31-378]
-------------------------------------------------------------------------------------
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
T
-----------
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
95.94
83%
-137
- C1 -
-
5AIK
1
DYR1A_HUMAN
B:
[31-378]
-------------------------------------------------------------------------------------
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
T
-----------
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
95.90
82%
-137
- C1 -
-
6EIQ
1
DYR1A_HUMAN
A:
[12-358]
-------------------------------------------------------------------------------------
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
T
-----------
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
95.88
83%
-142
- C1 -
-
6A1G
1
DYR1A_HUMAN
A:
[11-357]
-------------------------------------------------------------------------------------
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
------------------------------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
------------------------
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
95.72
82%
-135
- C1 -
-
3ANR
1
DYR1A_HUMAN
A:
[12-359]
-------------------------------------------------------------------------------------
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
T
-----------
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
95.65
83%
-138
- C1 -
-
6T6A
2
?
C:
[11-357]
--------------------------------------------------------------------------------------
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
T
--
K
-
D
G
-
K
R
--
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Blastp_CBE
95.45
83%
-137
- C1 -
-
6S1I
3
DYR1A_HUMAN
C:
[11-357]
--------------------------------------------------------------------------------------
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
----
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
T
----
D
G
-
K
R
--
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Blastp_CBE
95.44
83%
-138
- C1 -
-
4YLL
10
DYR1A_HUMAN
A:
[10-357]
-------------------------------------------------------------------------------------
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
-
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
------------
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
95.23
83%
-140
- C1 -
-
4YLK
13
DYR1A_HUMAN
A:
[10-357]
-------------------------------------------------------------------------------------
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
------------
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
95.01
83%
-137
- C1 -
-
4AZE
1
DYR1A_HUMAN
A:
[29-378]
-----------------------------------------------------------------------------------
E
R
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
T
--
K
-
D
G
-
K
R
--
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
Blastp_CBE
94.97
83%
-142
- C1 -
-
6S14
1
DYR1A_HUMAN
A:
[11-357]
--------------------------------------------------------------------------------------
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
-----------------
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
94.59
83%
-142
- C1 -
-
6S17
8
DYR1A_HUMAN
A:
[10-358]
-------------------------------------------------------------------------------------
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
------------
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
94.43
83%
-131
- C1 -
-
6S11
1
DYR1A_HUMAN
A:
[10-356]
-------------------------------------------------------------------------------------
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
T
-------
K
R
--
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
Blastp_CBE
94.31
83%
-137
- C1 -
-
4AZE
1
DYR1A_HUMAN
C:
[29-378]
-----------------------------------------------------------------------------------
E
R
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
T
--
K
-
D
G
-
K
R
--
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
94.09
83%
-142
- C1 -
-
6S1J
8
DYR1A_HUMAN
A:
[10-356]
-------------------------------------------------------------------------------------
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
-----------------
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
94.07
83%
-139
- C1 -
-
2WO6
1
DYR1A_HUMAN
B:
[33-377]
---------------------------------------------------------------------------------------
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
--------------------
K
R
--
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
94.03
83%
-132
- C1 -
-
2WO6
1
DYR1A_HUMAN
A:
[30-378]
------------------------------------------------------------------------------------
R
K
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
T
--------
R
--
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
93.87
83%
-138
- C1 -
-
4AZE
1
DYR1A_HUMAN
B:
[32-378]
--------------------------------------------------------------------------------------
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
T
--
K
-
D
G
-
K
R
--
E
----
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
93.70
83%
-142
- C1 -
-
6S1B
2
DYR1A_HUMAN
A:
[11-357]
--------------------------------------------------------------------------------------
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
----
D
G
T
---
W
-----
N
L
K
-----------
K
-----------------
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
557
HHSearch
93.65
83%
-143
- C1 -
-
6S1H
4
DYR1A_HUMAN
A:
[12-355]
---------------------------------------------------------------------------------------
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
-----------------
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
93.52
83%
-143
- C1 -
-
6S1H
4
DYR1A_HUMAN
A:
[12-355]
---------------------------------------------------------------------------------------
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------
K
-----------------
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
92.83
83%
-138
- C1 -
-
6A1G
1
DYR1A_HUMAN
B:
[12-357]
--------------------------------------------------------------------------------------
V
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
Y
Q
Y
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------------------------
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
E
T
G
G
P
G
G
R
R
A
G
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
Blastp_CBE
75.24
83%
-86
- C1 -
-
6S11
1
DYR1A_HUMAN
B:
[12-356]
---------------------------------------------------------------------------------------
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
-
K
N
G
E
K
W
M
-
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
-
V
A
I
K
I
I
K
---
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
--
T
E
M
K
-----
Y
Y
I
V
H
L
K
R
H
F
M
----
F
------
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
----
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
---
C
--------
N
----
P
-----------------
K
-------------------------
R
-
S
---------
A
---------
I
K
I
V
D
F
G
S
S
C
Q
L
--
G
Q
--
R
I
------
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
-
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
------
S
G
A
N
E
------
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
-
D
Q
A
P
K
-
A
R
K
F
-
F
--------
E
K
--
L
P
D
G
T
---
W
-----
N
L
K
-----------------------------
Y
--
K
P
P
G
T
R
K
L
H
N
I
L
G
V
-
T
G
G
P
G
G
R
---
E
S
G
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
70.96
44%
-97
- C1 -
-
5LXD
6
DYRK2_HUMAN
B:
[56-393]
----------------------------------------------------------------------------------------
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
-
V
P
H
D
H
V
A
-
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
-
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
-----
M
N
V
I
H
M
L
E
N
F
T
----
F
------
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
L
P
L
----
V
R
K
F
A
H
S
I
L
Q
C
L
--
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
---
K
--------
Q
----
Q
-----------------
G
-------------------------
R
-
S
---------
G
---------
I
K
V
I
D
F
G
S
S
C
Y
E
--
H
Q
--
R
V
Y
T
Y
---
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
-
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
------
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
-
D
A
S
K
R
-
A
K
N
F
--------------
V
S
S
K
G
---
Y
-----
P
R
Y
-----------
C
T
--
V
-
T
T
-
L
S
--
D
GSVV
L
--
N
G
G
R
S
R
R
-----
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
-
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
559
HHSearch
70.88
43%
-111
- C1 -
-
6HDP
1
DYRK2_HUMAN
A:
[93-418]
---------------------------------------------------------------------------------------------------------
D
H
V
A
-
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
-
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
-----
M
N
V
I
H
M
L
E
N
F
T
----
F
------
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
L
P
L
----
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
--
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
---
K
--------
Q
----
Q
-----------------
G
-------------------------
R
-
S
---------
G
---------
I
K
V
I
D
F
G
S
S
C
Y
E
--
H
Q
--
R
V
Y
T
Y
---
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
-
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
------
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
-
D
A
S
K
R
-
A
K
N
F
-
V
--------
S
S
--
K
G
Y
P
R
---
Y
-----
C
T
V
-----------
T
T
--
L
S
D
G
-
S
V
--
V
----
L
NG
G
R
S
R
R
G
K
L
R
G
P
P
-------
E
S
-
R
E
W
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
70.77
44%
-97
- C1 -
-
5LXD
6
DYRK2_HUMAN
A:
[56-393]
----------------------------------------------------------------------------------------
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
-
V
P
H
D
H
V
A
-
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
-
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
-----
M
N
V
I
H
M
L
E
N
F
T
----
F
------
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
L
P
L
----
V
R
K
F
A
H
S
I
L
Q
C
L
--
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
---
K
--------
Q
----
Q
-----------------
G
-------------------------
R
-
S
---------
G
---------
I
K
V
I
D
F
G
S
S
C
Y
E
--
H
Q
--
R
V
Y
T
Y
---
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
-
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
------
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
-
D
A
S
K
R
-
A
K
N
F
--------------
V
S
S
K
G
---
Y
-----
P
R
Y
-----------
C
T
--
V
-
T
T
-
L
S
--
D
GSVV
L
--
N
G
G
R
S
R
R
-----
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
-
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
70.27
44%
-96
- C1 -
-
5LXC
5
DYRK2_HUMAN
B:
[56-393]
----------------------------------------------------------------------------------------
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
-
V
P
H
D
H
V
A
-
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
-
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
-----
M
N
V
I
H
M
L
E
N
F
T
----
F
------
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
L
P
L
----
V
R
K
F
A
H
S
I
L
Q
C
L
--
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
---
K
--------
Q
----
Q
-----------------
G
-------------------------
R
-
S
---------
G
---------
I
K
V
I
D
F
G
S
S
C
Y
E
--
H
Q
--
R
V
Y
T
Y
---
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
-
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
------
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
-
D
A
S
K
R
-
A
K
N
F
--------------
V
S
S
K
G
---
Y
-----
P
R
Y
-----------
C
T
--
V
-
T
T
-
L
S
--
D
GSVV
L
--
N
G
G
R
S
R
R
-----
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
-
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
69.89
44%
-97
- C1 -
-
5LXC
9
DYRK2_HUMAN
A:
[56-392]
----------------------------------------------------------------------------------------
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
-
V
P
H
D
H
V
A
-
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
-
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
-----
M
N
V
I
H
M
L
E
N
F
T
----
F
------
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
L
P
L
----
V
R
K
F
A
H
S
I
L
Q
C
L
--
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
---
K
--------
Q
----
Q
-----------------
G
-------------------------
R
-
S
---------
G
---------
I
K
V
I
D
F
G
S
S
C
Y
E
--
H
Q
--
R
V
Y
T
Y
---
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
-
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
------
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
-
D
A
S
K
R
-
A
K
N
F
--------------
V
S
S
K
G
---
Y
-----
P
R
Y
-----------
C
T
--
V
-
T
T
-
L
S
--
D
GSVV
L
--
N
G
G
R
S
R
R
-----
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
-
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
558
HHSearch
69.68
44%
-111
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[93-413]
---------------------------------------------------------------------------------------------------------
D
H
V
A
-
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
-
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
-----
M
N
V
I
H
M
L
E
N
F
T
----
F
------
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
L
P
L
----
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
--
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
---
K
--------
Q
----
Q
-----------------
G
-------------------------
R
-
S
---------
G
---------
I
K
V
I
D
F
G
S
S
C
Y
E
--
H
Q
--
R
V
Y
T
Y
---
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
-
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
------
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
-
D
A
S
K
R
-
A
K
N
F
-
V
--------
S
S
--
K
G
Y
P
R
---
Y
-----
C
T
V
-----------
T
T
--
L
S
D
---
V
VL
N
----
G
--
G
R
S
R
R
G
K
L
R
G
P
P
---
E
-----
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
69.11
44%
-103
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[77-413]
----------------------------------------------------------------------------------------
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
-
V
P
H
D
H
V
A
-
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
-
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
-----
M
N
V
I
H
M
L
E
N
F
T
----
F
------
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
L
P
L
----
V
R
K
F
A
H
S
I
L
Q
C
L
--
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
---
K
--------
Q
----
Q
-----------------
G
-------------------------
R
-
S
---------
G
---------
I
K
V
I
D
F
G
S
S
C
Y
E
--
H
Q
--
R
V
Y
T
Y
---
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
-
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
------
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
-
D
A
S
K
R
-
A
K
N
F
-
V
--------
S
K
--
G
Y
P
R
Y
---
C
-----
T
V
T
-----------
T
L
--
S
-
D
G
-----
V
----
L
--
N
G
G
R
S
R
R
-----
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
-
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
564
HHSearch
69.10
41%
-102
- C1 -
-
5Y86
8
DYRK3_HUMAN
A:
[200-526]
------------------------------------------------------------------------------------------------------
V
P
R
D
H
L
A
-
Y
R
Y
E
V
L
K
I
I
G
K
G
S
F
G
Q
V
A
R
V
Y
D
-
H
-
K
L
R
-
Q
-
Y
-
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
K
K
Q
D
--
K
T
G
S
-----
M
N
V
I
H
M
L
E
S
F
T
----
F
------
R
N
----
H
V
C
M
A
F
E
L
L
S
I
D
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
V
Q
L
----
V
R
K
F
A
Q
S
I
L
Q
S
L
D
A
L
H
K
--
N
K
I
I
H
C
D
L
K
P
E
N
I
L
L
---
K
--------
H
----
H
-----------------
G
-------------------------
R
-
S
---------
S
---------
T
K
V
I
D
F
G
S
S
C
F
E
--
Y
Q
--
K
L
Y
T
Y
---
I
Q
S
R
F
Y
R
A
P
E
I
I
L
G
-
S
-
R
Y
-
S
T
P
I
D
I
W
S
F
G
C
I
L
A
E
L
L
T
G
Q
P
L
F
------
P
G
E
D
E
------
G
D
Q
L
A
C
M
M
E
L
L
G
M
P
P
P
K
L
L
-
E
Q
S
K
R
-
A
K
Y
F
-
I
--------
N
S
--
K
G
I
P
R
---
Y
-----
C
S
V
T----------
T
Q
--
A
-
D
G
-
R
V
--
V
----
L
--
V
G
G
R
S
R
R
G
K
K
R
G
-----
P
P
G
-
S
K
D
W
G
T
A
L
K
G
C
D
D
Y
L
F
I
E
F
L
K
R
C
L
H
W
D
P
S
A
R
L
T
P
A
Q
A
L
R
H
P
W
I
S
K
S
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
68.72
44%
-100
- C1 -
-
6HDR
2
DYRK2_HUMAN
A:
[77-413]
----------------------------------------------------------------------------------------
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
-
V
P
H
D
H
V
A
-
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
-
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
-----
M
N
V
I
H
M
L
E
N
F
T
----
F
------
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
L
P
L
----
V
R
K
F
A
H
S
I
L
Q
C
L
--
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
---
K
--------
Q
----
Q
-----------------
G
-------------------------
R
-
S
---------
G
---------
I
K
V
I
D
F
G
S
S
C
Y
E
--
H
Q
--
R
V
Y
T
Y
---
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
-
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
------
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
-
D
A
S
K
R
-
A
K
N
F
-
V
--------
S
K
--
G
Y
P
R
Y
---
C
-----
T
V
T
-----------
T
L
--
S
-
D
G
-----
V
----
L
--
N
G
G
R
S
R
R
-----
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
-
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
561
HHSearch
68.70
43%
-102
- C1 -
-
5LXC
5
DYRK2_HUMAN
B:
[71-394]
--------------------------------------------------------------------------------------------------------
H
D
H
V
A
-
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
-
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
-----
M
N
V
I
H
M
L
E
N
F
T
----
F
------
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
L
P
L
----
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
--
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
---
K
--------
Q
----
Q
-----------------
G
-------------------------
R
-
S
---------
G
---------
I
K
V
I
D
F
G
S
S
C
Y
E
--
H
Q
--
R
V
Y
T
Y
---
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
-
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
------
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
-
D
A
S
K
R
-
A
K
N
F
-
V
--------
S
S
--
K
G
Y
P
R
---
Y
-----
C
T
V
-----------
T
T
--
L
-
S
D
G
S
V
VL
N
----
G
--
G
R
S
R
R
G
K
L
R
G
P
P
---
E
-----
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
67.95
44%
-101
- C1 -
-
3KVW
1
DYRK2_HUMAN
A:
[77-413]
----------------------------------------------------------------------------------------
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
-
V
P
H
D
H
V
A
-
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
-
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
-----
M
N
V
I
H
M
L
E
N
F
T
----
F
------
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
L
P
L
----
V
R
K
F
A
H
S
I
L
Q
C
L
--
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
---
K
--------
Q
----
Q
-----------------
G
-------------------------
R
-
S
---------
G
---------
I
K
V
I
D
F
G
S
S
C
Y
E
--
H
Q
--
R
V
Y
T
Y
---
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
-
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
------
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
-
D
A
S
K
R
-
A
K
N
F
-
V
--------
S
K
--
G
Y
P
R
Y
---
C
-----
T
V
T
-----------
T
L
--
S
-
D
G
-----
V
----
L
--
N
G
G
R
S
R
R
-----
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
-
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
67.92
44%
-99
- C1 -
-
6HDP
1
DYRK2_HUMAN
A:
[77-414]
----------------------------------------------------------------------------------------
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
-
V
P
H
D
H
V
A
-
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
-
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
-----
M
N
V
I
H
M
L
E
N
F
T
----
F
------
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
L
P
L
----
V
R
K
F
A
H
S
I
L
Q
C
L
--
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
---
K
--------
Q
----
Q
-----------------
G
-------------------------
R
-
S
---------
G
---------
I
K
V
I
D
F
G
S
S
C
Y
E
--
H
Q
--
R
V
Y
T
Y
---
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
-
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
------
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
-
D
A
S
K
R
-
A
K
N
F
-
V
--------
S
K
--
G
Y
P
R
Y
---
C
-----
T
V
T
-----------
T
L
--
S
-
D
G
-
S
V
--
V
----
L
--
N
G
G
R
S
R
R
-----
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
-
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
67.57
44%
-100
- C1 -
-
5ZTN
1
DYRK2_HUMAN
A:
[77-413]
----------------------------------------------------------------------------------------
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
-
V
P
H
D
H
V
A
-
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
-
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
-----
M
N
V
I
H
M
L
E
N
F
T
----
F
------
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
L
P
L
----
V
R
K
F
A
H
S
I
L
Q
C
L
--
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
---
K
--------
Q
----
Q
-----------------
G
-------------------------
R
-
S
---------
G
---------
I
K
V
I
D
F
G
S
S
C
Y
E
--
H
Q
--
R
V
Y
T
Y
---
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
-
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
------
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
-
D
A
S
K
R
-
A
K
N
F
-
V
--------
S
K
--
G
Y
P
R
Y
---
C
-----
T
V
T
-----------
T
-----------------
L
--
N
G
G
R
S
R
R
-----
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
-
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
566
HHSearch
67.55
44%
-105
- C1 -
-
6K0J
1
?
A:
[7-326]
-----------------------------------------------------------------------------------------------------------
V
A
-
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
-
V
A
L
K
M
V
R
---
N
N
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
-----
M
N
V
I
H
M
L
E
N
F
T
----
F
------
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
L
P
L
----
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
--
N
R
I
I
H
C
D
A
K
P
E
N
I
L
L
---
K
--------
Q
----
Q
-----------------
G
-------------------------
R
-
S
---------
G
---------
I
K
V
I
D
F
G
S
S
C
Y
E
--
H
Q
--
R
V
Y
T
Y
---
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
-
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
------
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
-
D
A
S
K
R
-
A
K
N
F
-
V
--------
S
S
--
K
G
Y
P
R
YCT
V
-----
T
T
L
-----------
S
D
--
G
-
S
V
-
V
L
--
N
----
G
--
G
R
S
R
R
G
K
L
---
R
G
P
----
P
E
-
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
67.30
45%
-103
- C1 -
-
6K0J
1
?
A:
[10-325]
---------------------------------------------------------------------------------------------------------------
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
-
V
A
L
K
M
V
R
---
N
N
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
-----
M
N
V
I
H
M
L
E
N
F
T
----
F
------
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
L
P
L
----
V
R
K
F
A
H
S
I
L
Q
C
L
--
D
A
L
H
K
N
R
I
I
H
C
D
A
K
P
E
N
I
L
L
---
K
--------
Q
----
Q
-----------------
G
-------------------------
R
-
S
---------
G
---------
I
K
V
I
D
F
G
S
S
C
Y
E
--
H
Q
--
R
V
Y
T
Y
---
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
-
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
------
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
-
D
A
S
K
R
-
A
K
N
F
-
V
--------
S
K
--
G
Y
P
R
Y
---
C
-----
T
V
T
-----------
T
L
--
S
-
D
G
-
S
V
--
V
----
L
--
N
G
G
R
S
R
R
-----
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
-
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
66.79
44%
-100
- C1 -
-
5ZTN
1
DYRK2_HUMAN
B:
[77-413]
----------------------------------------------------------------------------------------
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
-
V
P
H
D
H
V
A
-
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
-
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
--
K
D
N
T
-----
M
N
V
I
H
M
L
E
N
F
T
----
F
------
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
L
P
L
----
V
R
K
F
A
H
S
I
L
Q
C
L
--
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
---
K
--------
Q
----
Q
-----------------
G
-------------------------
R
-
S
---------
G
---------
I
K
V
I
D
F
G
S
S
C
Y
E
--
H
Q
--
R
V
Y
T
Y
---
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
-
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
------
P
G
E
D
E
------
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
-
D
A
S
K
R
-
A
K
N
F
-
V
--------
S
K
--
G
Y
P
R
Y
---
C
-----
T
V
T
-----------
T
-----------------
L
--
N
G
G
R
S
R
R
-----
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
-
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
60.66
33%
-60
- C1 -
-
6I5I
13
CLK1_HUMAN
A:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
---------
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
60.07
33%
-51
- C1 -
-
6FYO
1
CLK1_HUMAN
A:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
--------------------------------------------------
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HHDRLDWD
E
H
--
S
S
A
G
R
---
Y
-----
V
S
R
-----------
R
C
--
K
-
P
L
-
K
--------------------
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
565
HHSearch
59.89
33%
-52
- C1 -
-
6KHE
1
CLK2_HUMAN
A:
[153-485]
----------------------------------------------------------------------------------------------------
Y
-
H
V
G
D
W
L
Q
-
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
-
R
G
G
-
A
-
R
-
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
--
P
D
N
K
-----
N
L
C
V
Q
M
F
D
W
F
D
----
Y
------
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
--
N
Y
L
P
Y
P
I
H
Q
----
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
----
S
-----------------
D
YELTYNLEKKRDERSVK--------
S
-
T
---------
A
---------
V
R
V
V
D
F
G
S
A
T
F
D
--
H
E
--
H
H
S
T
I
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
------
Q
T
H
D
N
------
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
-
R
K
T
R
K
-
Q
K
Y
F
-
Y
--------
R
G
--
R
--
L
D
---
W
-----
D
E
N
-----------
T
S
--
A
----
G
---
R
----
Y
--
V
R
E
N
C
K
P
L
R
R
Y
---------------
L
T
S
E
A
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
562
HHSearch
59.75
34%
-48
- C1 -
-
6KHD
1
CLK1_HUMAN
A:
[150-481]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
-
A
G
G
-
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
--
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
Q
----
S
-----------------
D
YTEERTLI-----------------
N
-
P
---------
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
--
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
-
Q
K
T
R
K
--
R
K
Y
-
F
--------
H
H
--
D
R
-
L
D
---
W
-----
D
E
H
-----------
S
S
--
A
-
G
------
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
---------------
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
59.71
33%
-46
- C1 -
-
6Q8K
2
CLK1_HUMAN
A:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
59.54
33%
-48
- C1 -
-
6RAA
2
CLK1_HUMAN
A:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
170
Blastp_CBE
58.96
33%
-42
- C1 -
-
5J1W
6
CLK1_HUMAN
A:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
58.95
33%
-54
- C1 -
-
6G33
1
CLK1_HUMAN
C:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
----------------
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
58.76
33%
-48
- C1 -
-
1Z57
1
CLK1_HUMAN
A:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
---------------------------------------------------RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
156
Blastp_CBE
58.76
33%
-45
- C1 -
-
6I5L
3
CLK1_HUMAN
A:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
155
Blastp_CBE
58.69
33%
-46
- C1 -
-
6I5L
2
CLK1_HUMAN
B:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
152
Blastp_CBE
58.69
33%
-43
- C1 -
-
6Q8P
1
CLK1_HUMAN
A:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
-
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
58.62
33%
-46
- C1 -
-
6I5L
4
CLK1_HUMAN
C:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
164
Blastp_CBE
58.61
33%
-43
- C1 -
-
6FT9
2
CLK1_HUMAN
C:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
58.61
41%
-66
- C1 -
-
5Y86
8
DYRK3_HUMAN
A:
[187-526]
----------------------------------------------------------------------------------------
N
G
G
Y
D
D
A
D
G
A
Y
I
H
-
V
P
R
D
H
L
A
-
Y
R
Y
E
V
L
K
I
I
G
K
G
S
F
G
Q
V
A
R
V
Y
D
-
H
-
K
L
R
-
Q
-
Y
-
V
A
L
K
M
V
R
---
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
K
K
Q
D
--
K
T
G
S
-----
M
N
V
I
H
M
L
E
S
F
T
----
F
------
R
N
----
H
V
C
M
A
F
E
L
L
S
I
D
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
V
Q
L
----
V
R
K
F
A
Q
S
I
L
Q
S
L
D
A
L
H
K
N
K
--
I
I
H
C
D
L
K
P
E
N
I
L
L
---
K
--------
H
----
H
-----------------
G
-------------------------
R
-
S
---------
T
----------
K
V
I
D
F
G
S
S
C
F
E
--
Y
Q
--
K
L
Y
T
----
I
Q
S
R
F
Y
R
A
P
E
I
I
L
G
-
S
-
R
Y
-
S
T
P
I
D
I
W
S
F
G
C
I
L
A
E
L
L
T
G
Q
P
L
F
------
P
G
E
D
E
------
G
D
Q
L
A
C
M
M
E
L
L
G
M
P
P
P
K
L
L
-
E
Q
S
K
R
-
A
K
Y
F
-
I
--------
N
K
--
G
I
P
R
Y
---
C
-----
S
V
T
-----------
T
Q
--
A
-
D
G
-
R
V
--
V
----
L
--
V
G
G
R
S
R
R
-----
G
K
K
R
G
P
P
G
S
K
D
W
G
T
A
L
K
G
C
D
D
Y
L
-
F
I
E
F
L
K
R
C
L
H
W
D
P
S
A
R
L
-
P
A
Q
A
L
R
H
P
W
I
S
K
S
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
168
Blastp_CBE
58.50
33%
-60
- C1 -
-
5J1W
5
CLK1_HUMAN
C:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
--------------------------------------------------------------------
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
58.41
33%
-44
- C1 -
-
6FT9
4
CLK1_HUMAN
A:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
58.39
33%
-44
- C1 -
-
6I5K
5
CLK1_HUMAN
B:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
157
Blastp_CBE
58.35
33%
-45
- C1 -
-
6I5K
3
CLK1_HUMAN
C:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
58.26
33%
-42
- C1 -
-
6G33
1
CLK1_HUMAN
B:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
58.23
33%
-43
- C1 -
-
5J1V
2
CLK1_HUMAN
A:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
58.17
33%
-67
- C1 -
-
5J1V
2
CLK1_HUMAN
C:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
---
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-------------------------------------------------------------------
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
167
Blastp_CBE
58.16
33%
-44
- C1 -
-
6FT8
7
CLK1_HUMAN
A:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
58.11
33%
-45
- C1 -
-
6Q8P
1
CLK1_HUMAN
B:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
----------------------------------------------RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
--
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
172
Blastp_CBE
57.94
33%
-42
- C1 -
-
5J1V
1
CLK1_HUMAN
B:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
179
Blastp_CBE
57.88
32%
-32
- C1 -
-
6FYP
1
CLK3_HUMAN
A:
[14-348]
--------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
-
R
I
G
D
W
L
Q
-
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
-
Q
-
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
--
K
E
N
K
-----
F
L
C
V
L
M
S
D
W
F
N
----
F
------
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
--
N
F
Q
P
Y
P
L
P
H
----
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
----
S
EFETLYNEHKSCEEKSV
K
-------------------------
N
-
T
---------
S
---------
I
R
V
A
D
F
G
S
A
T
F
D
--
H
E
--
H
H
T
T
I
---
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
-
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
------
Q
T
H
E
N
------
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
-
H
R
T
R
K
--
Q
K
Y
-
F
--------
Y
K
---
G
G
L
V
---
W
-----
D
E
N
-----------
S
S
DG
R
-
Y
V
-
K
E
--
N
----
C
--
K
P
L
K
S
Y
M
L
Q
D
S
L
--------------------
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
159
Blastp_CBE
57.84
33%
-43
- C1 -
-
6I5K
3
CLK1_HUMAN
A:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
57.59
33%
-40
- C1 -
-
5X8I
1
CLK1_HUMAN
A:
[8-331]
--------------------------------------------------------------------------------------------------------
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
169
Blastp_CBE
57.58
33%
-40
- C1 -
-
5J1W
3
CLK1_HUMAN
B:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
57.20
32%
-30
- C1 -
-
6FYR
1
CLK3_HUMAN
A:
[14-348]
--------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
-
R
I
G
D
W
L
Q
-
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
-
Q
-
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
--
K
E
N
K
-----
F
L
C
V
L
M
S
D
W
F
N
----
F
------
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
--
N
F
Q
P
Y
P
L
P
H
----
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
----
S
EFETLYNEHKSCEEKSV
K
-------------------------
N
-
T
---------
S
---------
I
R
V
A
D
F
G
S
A
T
F
D
--
H
E
--
H
H
T
T
I
---
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
-
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
------
Q
T
H
E
N
------
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
-
H
R
T
R
K
--
Q
K
Y
-
F
--------
Y
K
---
G
G
L
V
---
W
-----
D
E
N
-----------
S
S
DG
R
-
Y
V
-
K
E
--
N
----
C
--
K
P
L
K
S
Y
M
L
Q
D
S
L
--------------------
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
175
Blastp_CBE
57.16
33%
-39
- C1 -
-
5X8I
1
CLK1_HUMAN
B:
[9-331]
---------------------------------------------------------------------------------------------------------
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
57.01
32%
-35
- C1 -
-
6RCT
8
CLK3_HUMAN
A:
[14-348]
--------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
-
R
I
G
D
W
L
Q
-
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
-
Q
-
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
--
K
E
N
K
-----
F
L
C
V
L
M
S
D
W
F
N
----
F
------
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
--
N
F
Q
P
Y
P
L
P
H
----
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
----
S
EFETLYNEHKSCEEKSV
K
-------------------------
N
-
T
---------
S
---------
I
R
V
A
D
F
G
S
A
T
F
D
--
H
E
--
H
H
T
T
I
---
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
-
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
------
Q
T
H
E
N
------
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
-
H
R
T
R
K
--
Q
K
Y
-
F
--------
Y
K
---
G
G
L
V
---
W
-----
D
E
N
-----------
S
S
DG
R
-
Y
V
-
K
E
--
N
----
C
--
K
P
L
K
S
Y
M
L
Q
D
S
L
--------------------
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
56.99
33%
-42
- C1 -
-
6FT9
2
CLK1_HUMAN
B:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
56.93
33%
-43
- C1 -
-
6Q8P
1
CLK1_HUMAN
C:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
---------------------------------------------
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
-
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
56.72
32%
-36
- C1 -
-
6RCT
7
CLK3_HUMAN
B:
[14-348]
--------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
-
R
I
G
D
W
L
Q
-
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
-
Q
-
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
--
K
E
N
K
-----
F
L
C
V
L
M
S
D
W
F
N
----
F
------
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
--
N
F
Q
P
Y
P
L
P
H
----
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
----
S
EFETLYNEHKSCEEKSV
K
-------------------------
N
-
T
---------
S
---------
I
R
V
A
D
F
G
S
A
T
F
D
--
H
E
--
H
H
T
T
I
---
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
-
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
------
Q
T
H
E
N
------
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
-
H
R
T
R
K
--
Q
K
Y
-
F
--------
Y
K
---
G
G
L
V
---
W
-----
D
E
N
-----------
S
S
DG
R
-
Y
V
-
K
E
--
N
----
C
--
K
P
L
K
S
Y
M
L
Q
D
S
L
--------------------
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
203
Blastp_CBE
56.57
32%
-36
- C1 -
-
6FYV
1
CLK4_HUMAN
A:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
R
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
G
M
D
-
G
-
M
H
V
A
V
K
I
V
K
---
N
V
G
R
Y
R
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
S
T
D
--
P
N
S
V
-----
F
R
C
V
Q
M
L
E
W
F
D
----
H
------
H
G
----
H
V
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
S
F
L
P
F
Q
I
D
H
----
I
R
Q
M
A
Y
Q
I
C
Q
S
I
N
F
L
H
H
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
K
----
S
DYVVKYNKRDERTL---
K
-------------------------
N
-
T
---------
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
Q
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
I
P
Q
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HHNQLDWD
E
H
--
S
S
A
G
R
---
Y
-----
V
R
R
-----------
R
C
--
K
-
P
L
-
K
--------------------
E
F
M
L
C
H
---------------
D
E
E
H
E
K
L
F
D
L
V
R
R
M
L
E
Y
D
P
T
Q
R
I
T
L
D
E
A
L
Q
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
563
HHSearch
56.39
34%
-41
- C1 -
-
6KHD
1
CLK1_HUMAN
B:
[151-481]
----------------------------------------------------------------------------------------------------
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
-
A
G
G
-
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
--
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
Q
----
S
-----------------
D
YTEAYNPKRDERTLI----------
N
-
P
---------
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
-
Q
K
T
R
--
K
R
K
Y
-
F
--------
H
H
--
D
R
-
L
D
---
W
-----
D
E
H
-----------
S
S
-----
A
-
G
R
--
Y
----
V
--
S
-
R
A
C
K
P
L
K
E
F
M
---------------
L
S
Q
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
202
Blastp_CBE
56.37
32%
-35
- C1 -
-
2WU6
7
CLK3_HUMAN
A:
[35-369]
--------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
-
R
I
G
D
W
L
Q
-
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
-
Q
-
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
--
K
E
N
K
-----
F
L
C
V
L
M
S
D
W
F
N
----
F
------
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
--
N
F
Q
P
Y
P
L
P
H
----
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
----
S
EFETLYNEHKSCEEKSV
K
-------------------------
N
-
T
---------
S
---------
I
R
V
A
D
F
G
S
A
T
F
D
--
H
E
--
H
H
T
T
I
---
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
-
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
------
Q
T
H
E
N
------
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
-
H
R
T
R
K
--
Q
K
Y
-
F
--------
Y
K
---
G
G
L
V
---
W
-----
D
E
N
-----------
S
S
DG
R
-
Y
V
-
K
E
--
N
----
C
--
K
P
L
K
S
Y
M
L
Q
D
S
L
--------------------
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
56.37
32%
-33
- C1 -
-
2WU7
1
CLK3_HUMAN
A:
[35-369]
--------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
-
R
I
G
D
W
L
Q
-
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
-
Q
-
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
--
K
E
N
K
-----
F
L
C
V
L
M
S
D
W
F
N
----
F
------
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
--
N
F
Q
P
Y
P
L
P
H
----
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
----
S
EFETLYNEHKSCEEKSV
K
-------------------------
N
-
T
---------
S
---------
I
R
V
A
D
F
G
S
A
T
F
D
--
H
E
--
H
H
T
T
I
---
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
-
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
------
Q
T
H
E
N
------
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
-
H
R
T
R
K
--
Q
K
Y
-
F
--------
Y
K
---
G
G
L
V
---
W
-----
D
E
N
-----------
S
S
DG
R
-
Y
V
-
K
E
--
N
----
C
--
K
P
L
K
S
Y
M
L
Q
D
S
L
--------------------
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
56.36
32%
-33
- C1 -
-
3RAW
1
CLK3_HUMAN
B:
[35-369]
--------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
-
R
I
G
D
W
L
Q
-
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
-
Q
-
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
--
K
E
N
K
-----
F
L
C
V
L
M
S
D
W
F
N
----
F
------
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
--
N
F
Q
P
Y
P
L
P
H
----
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
----
S
EFETLYNEHKSCEEKSV
K
-------------------------
N
-
T
---------
S
---------
I
R
V
A
D
F
G
S
A
T
F
D
--
H
E
--
H
H
T
T
I
---
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
-
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
------
Q
T
H
E
N
------
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
-
H
R
T
R
K
--
Q
K
Y
-
F
--------
Y
K
---
G
G
L
V
---
W
-----
D
E
N
-----------
S
S
DG
R
-
Y
V
-
K
E
--
N
----
C
--
K
P
L
K
S
Y
M
L
Q
D
S
L
--------------------
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
161
Blastp_CBE
55.96
33%
-44
- C1 -
-
6I5H
6
CLK1_HUMAN
A:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYT-------------------------------------------------------RTLINP---
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
189
Blastp_CBE
55.84
32%
-32
- C1 -
-
6FT7
7
CLK3_HUMAN
B:
[14-348]
--------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
-
R
I
G
D
W
L
Q
-
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
-
Q
-
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
--
K
E
N
K
-----
F
L
C
V
L
M
S
D
W
F
N
----
F
------
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
--
N
F
Q
P
Y
P
L
P
H
----
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
----
S
EFETLYNEHKSCEEKSV
K
-------------------------
N
-
T
---------
S
---------
I
R
V
A
D
F
G
S
A
T
F
D
--
H
E
--
H
H
T
T
I
---
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
-
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
------
Q
T
H
E
N
------
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
-
H
R
T
R
K
--
Q
K
Y
-
F
--------
Y
K
---
G
G
L
V
---
W
-----
D
E
N
-----------
S
S
DG
R
-
Y
V
-
K
E
--
N
----
C
--
K
P
L
K
S
Y
M
L
Q
D
S
L
--------------------
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
55.60
32%
-33
- C1 -
-
3RAW
1
CLK3_HUMAN
A:
[35-369]
--------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
-
R
I
G
D
W
L
Q
-
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
-
Q
-
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
--
K
E
N
K
-----
F
L
C
V
L
M
S
D
W
F
N
----
F
------
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
--
N
F
Q
P
Y
P
L
P
H
----
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
----
S
EFETLYNEHKSCEEKSV
K
-------------------------
N
-
T
---------
S
---------
I
R
V
A
D
F
G
S
A
T
F
D
--
H
E
--
H
H
T
T
I
---
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
-
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
------
Q
T
H
E
N
------
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
-
H
R
T
R
K
--
Q
K
Y
-
F
--------
Y
K
---
G
G
L
V
---
W
-----
D
E
N
-----------
S
S
DG
R
-
Y
V
-
K
E
--
N
----
C
--
K
P
L
K
S
Y
M
L
Q
D
S
L
--------------------
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
206
Blastp_CBE
55.47
31%
-39
- C1 -
-
6KHF
1
CLK3_HUMAN
A:
[142-472]
------------------------------------------------------------------------------------------------
G
H
L
V
C
-
R
I
G
D
W
L
Q
-
E
D
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
-
Q
-
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
--
K
E
N
K
-----
F
L
C
V
L
M
S
D
W
F
N
----
F
------
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
--
N
F
Q
P
Y
P
L
P
H
----
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
----
S
EFSV-------------
K
-------------------------
N
-
T
---------
S
---------
I
R
V
A
D
F
G
S
A
T
F
D
--
H
E
--
H
H
T
T
I
---
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
-
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
------
Q
T
H
E
N
------
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
-
H
R
T
R
K
--
Q
K
Y
-
F
--------
Y
K
---
G
G
L
V
---
W
-----
D
E
N
-----------
S
S
DG
R
-
Y
V
-
K
E
--
N
----
C
--
K
P
L
K
S
Y
M
L
Q
D
S
L
--------------------
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
55.16
37%
-77
- C1 -
-
6P5S
1
HIPK2_HUMAN
A:
[42-373]
----------------------------------------------------------------------------------------------------------------
Y
E
V
L
E
F
L
G
R
---
G
Q
V
V
K
C
W
K
-
R
-
G
T
N
-
E
-
I
-
V
A
I
K
I
L
----------
R
Q
G
Q
I
E
V
S
I
L
A
R
L
S
T
E
S
--
A
D
-
D
-----
Y
N
F
V
R
A
Y
E
C
F
Q
----
H
------------
H
T
C
L
V
F
E
M
L
E
Q
N
L
Y
D
F
L
K
Q
N
--
K
F
S
P
L
P
L
K
Y
----
I
R
P
V
L
Q
Q
V
A
T
A
L
M
K
L
K
S
--
L
G
L
I
H
A
D
L
K
P
E
N
I
M
L
---
V
--------
D
----
P
-----------------
S
-------------------------
R
-
Q
PY-------
R
---------
V
K
V
I
D
F
G
S
A
S
H
V
---------
S
T
---
L
Q
S
R
Y
Y
R
A
P
E
I
I
L
G
-
L
-
P
F
-
C
E
A
I
D
M
W
S
L
G
C
V
I
A
E
L
F
L
G
W
P
L
Y
------
P
G
A
S
E
------
Y
D
Q
I
R
Y
I
S
Q
T
Q
G
L
P
A
E
Y
L
L
-
S
A
G
T
K
-
T
T
R
F
-
F
--------
N
R
DT
D
P
Y
P
L
---
W
-----
R
L
K
TPDDHEAETGI
K
S
--
K
-
E
A
-
R
K
-------
Y
--
I
F
N
C
L
D
D
M
A
Q
V
-
N
M
T
T
D
L
E
G
S
D
M
L
V
E
----
K
A
D
R
R
E
F
I
D
L
L
K
K
M
L
T
I
D
A
D
K
R
I
T
P
I
E
T
L
N
H
P
F
V
T
M
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
55.15
32%
-28
- C1 -
-
6FT7
7
CLK3_HUMAN
A:
[14-348]
--------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
-
R
I
G
D
W
L
Q
-
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
-
Q
-
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
--
K
E
N
K
-----
F
L
C
V
L
M
S
D
W
F
N
----
F
------
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
--
N
F
Q
P
Y
P
L
P
H
----
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
Q
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
----
S
EFETLYNEHKSCEEKSV
K
-------------------------
N
-
T
---------
S
---------
I
R
V
A
D
F
G
S
A
T
F
D
--
H
E
--
H
H
T
T
I
---
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
-
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
------
Q
T
H
E
N
------
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
-
H
R
T
R
K
--
Q
K
Y
-
F
--------
Y
K
---
G
G
L
V
---
W
-----
D
E
N
-----------
S
S
DG
R
-
Y
V
-
K
E
--
N
----
C
--
K
P
L
K
S
Y
M
L
Q
D
S
L
--------------------
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
54.90
31%
-24
- C1 -
-
6KHD
1
CLK1_HUMAN
A:
[149-477]
---------------------------------------------------------------------------------------------------
L
I
C
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTE----------------------------------------------------------------ERTLINPD-
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
--
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
D
------
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
569
HHSearch
54.84
31%
-15
- C1 -
-
5XV7
5
SRPK1_HUMAN
A:
[7-371]
--------------------------------------------------------------------------------------------------------
G
D
L
F
N
-
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
-
I
-
Q
G
K
-
K
-
F
-
V
A
M
K
V
V
K
---
S
A
E
H
Y
T
E
T
A
L
D
E
I
R
L
L
K
S
V
R
N
S
D
PN
D
P
N
R
-----
E
M
V
V
Q
L
L
D
D
F
K
ISGV
N
------
G
T
----
H
I
V
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
S
--
N
Y
Q
G
L
P
L
P
C
----
V
K
K
I
I
Q
Q
V
L
Q
G
L
D
Y
L
H
T
K
-
C
R
I
I
H
T
D
I
K
P
E
N
I
L
L
---
S
--------
V
----
N
-----------------
E
QYIRRLAAEATENFLVNPLEPKNAE
K
-
L
---------
K
---------
V
K
I
A
D
L
G
N
A
C
W
V
--
H
K
--
H
F
T
E
D
---
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
-
S
-
G
Y
-
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
------
E
P
H
S
G
EEYTRD
E
D
H
I
A
L
I
I
E
L
L
G
K
V
P
R
K
L
I
-
V
A
G
K
Y
-
S
K
E
F
-
F
--------
T
K
--
K
G
D
-----
L
-----
K
H
I
---------------
T
-
K
L
-
K
---
P
----
W
--------
G
L
F
E
V
L
-----------
V
E
K
Y
E
W
S
Q
E
E
A
A
G
F
T
D
F
L
L
P
M
L
E
L
I
P
E
K
R
A
T
A
A
E
C
L
R
H
P
W
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
54.62
32%
-4
- C1 -
-
3NR9
1
CLK2_HUMAN
B:
[16-354]
--------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
-
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
-
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
--
P
D
N
K
-----
N
L
C
V
Q
M
F
D
W
F
D
----
Y
------
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
--
N
Y
L
P
Y
P
I
H
Q
----
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
----
S
DYELTYNLEKKRDERSV
K
-------------------------
S
-
T
---------
A
---------
V
R
V
V
D
F
G
S
A
T
F
D
--
H
E
--
H
H
S
T
I
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
------
Q
T
H
D
N
------
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
-
R
K
T
R
K
--
Q
K
Y
-
F
--------
Y
R
----------------------------------
G
-
R
L
-
D
W
--
D
----
E
--
N
T
S
A
G
R
Y
V
R
E
-----
N
C
K
P
L
R
R
Y
L
T
S
E
A
---
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
54.60
32%
-8
- C1 -
-
3NR9
1
CLK2_HUMAN
A:
[16-356]
--------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
-
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
-
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
--
P
D
N
K
-----
N
L
C
V
Q
M
F
D
W
F
D
----
Y
------
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
--
N
Y
L
P
Y
P
I
H
Q
----
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
----
S
DYELTDERSV-------
K
-------------------------
S
-
T
---------
A
---------
V
R
V
V
D
F
G
S
A
T
F
D
--
H
E
--
H
H
S
T
I
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
------
Q
T
H
D
N
------
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
-
R
K
T
R
K
--
Q
K
Y
-
F
--------
Y
R
----------------------------------
G
-
R
L
-
D
W
--
D
----
E
--
N
T
S
A
G
R
Y
V
R
E
-----
N
C
K
P
L
R
R
Y
L
T
S
E
A
---
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
54.59
32%
-9
- C1 -
-
5UNP
1
CLK2_HUMAN
A:
[17-356]
--------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
-
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
-
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
--
P
D
N
K
-----
N
L
C
V
Q
M
F
D
W
F
D
----
Y
------
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
--
N
Y
L
P
Y
P
I
H
Q
----
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
----
S
DYELTYNLEKKRDERSV
K
-------------------------
S
-
T
---------
A
---------
V
R
V
V
D
F
G
S
A
T
F
D
--
H
E
--
H
H
S
T
I
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
------
Q
T
H
D
N
------
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
-
R
K
T
R
K
--
Q
K
Y
-
F
--------
Y
R
----------------------------------
G
-
R
L
-
D
W
--
D
----
E
--
N
T
S
A
G
R
Y
V
R
E
-----
N
C
K
P
L
R
R
Y
L
T
S
E
A
---
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
54.26
32%
-9
- C1 -
-
5UNP
1
CLK2_HUMAN
B:
[17-356]
--------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
-
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
-
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
--
P
D
N
K
-----
N
L
C
V
Q
M
F
D
W
F
D
----
Y
------
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
--
N
Y
L
P
Y
P
I
H
Q
----
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
----
S
DYELTYNLEKKRDERSV
K
-------------------------
S
-
T
---------
A
---------
V
R
V
V
D
F
G
S
A
T
F
D
--
H
E
--
H
H
S
T
I
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
------
Q
T
H
D
N
------
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
-
R
K
T
R
K
--
Q
K
Y
-
F
--------
Y
R
----------------------------------
G
-
R
L
-
D
W
--
D
----
E
--
N
T
S
A
G
R
Y
V
R
E
-----
N
C
K
P
L
R
R
Y
L
T
S
E
A
---
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
54.19
32%
-5
- C1 -
-
6FYK
1
CLK2_HUMAN
C:
[11-352]
--------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
-
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
-
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
--
P
D
N
K
-----
N
L
C
V
Q
M
F
D
W
F
D
----
Y
------
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
--
N
Y
L
P
Y
P
I
H
Q
----
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
----
S
DYELTYNLEKKRDERSV
K
-------------------------
S
-
T
---------
A
---------
V
R
V
V
D
F
G
S
A
T
F
D
--
H
E
--
H
H
S
T
I
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
------
Q
T
H
D
N
------
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
-
R
K
T
R
K
--
Q
K
Y
-
F
--------
Y
R
----------------------------------
G
-
R
L
-
D
W
--
D
----
E
--
N
T
S
A
G
R
Y
V
R
E
-----
N
C
K
P
L
R
R
Y
L
T
S
E
A
---
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
54.06
32%
1
- C1 -
-
6FYL
1
CLK2_HUMAN
A:
[11-350]
--------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
-
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
-
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
--
P
D
N
K
-----
N
L
C
V
Q
M
F
D
W
F
D
----
Y
------
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
--
N
Y
L
P
Y
P
I
H
Q
----
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
----
S
DYELTYNLEKKRDERSV
K
-------------------------
S
-
T
---------
A
---------
V
R
V
V
D
F
G
S
A
T
F
D
--
H
E
--
H
H
S
T
I
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
------
Q
T
H
D
N
------
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
-
R
K
T
R
K
--
Q
K
Y
-
F
--------
Y
R
----------------------------------
G
-
R
L
-
D
W
--
D
----
E
--
N
T
S
A
G
R
Y
V
R
E
-----
N
C
K
P
L
R
R
Y
L
T
S
E
A
---
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
560
HHSearch
54.03
33%
-29
- C1 -
-
6KHF
1
CLK3_HUMAN
A:
[146-480]
----------------------------------------------------------------------------------------------------
C
-
R
I
G
D
W
L
Q
-
E
D
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
-
A
R
G
-
K
S
Q
-
V
A
L
K
I
I
R
---
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
--
K
E
N
K
-----
F
L
C
V
L
M
S
D
W
F
N
----
F
------
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
--
N
F
Q
P
Y
P
L
P
H
----
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
--
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
SEFS
V
-----------------
K
-------------------------
N
-
T
---------
S
---------
I
R
V
A
D
F
G
S
A
T
F
D
--
H
E
--
H
H
T
T
I
---
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
-
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
------
Q
T
H
E
N
------
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
-
H
R
T
R
K
-
Q
K
Y
F
-
Y
--------
K
G
--
G
L
--
V
---
W
-----
D
E
N
-----------
S
S
--
D
-
G
------
R
----
Y
--
V
K
E
N
C
K
P
L
K
S
Y
M
---------------
L
Q
D
S
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
E
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
180
Blastp_CBE
53.97
33%
0
- C1 -
-
6KHE
1
CLK2_HUMAN
A:
[144-481]
--------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
-
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
-
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
--
P
D
N
K
-----
N
L
C
V
Q
M
F
D
W
F
D
----
Y
------
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
--
N
Y
L
P
Y
P
I
H
Q
----
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
----
S
DYELTYNLEKKRDERSV
K
-------------------------
S
-
T
---------
A
---------
V
R
V
V
D
F
G
S
A
T
F
D
--
H
E
--
H
H
S
T
I
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
------
Q
T
H
D
N
------
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
-
R
K
T
R
K
--
Q
K
Y
-
F
--------
Y
R
----------------------------------
G
-
R
L
-
D
W
--
D
----
E
--
N
T
S
A
G
R
Y
V
R
E
-----
N
C
K
P
L
R
R
Y
L
T
S
E
A
---
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
53.96
32%
1
- C1 -
-
6FYK
1
CLK2_HUMAN
B:
[11-352]
--------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
-
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
-
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
--
P
D
N
K
-----
N
L
C
V
Q
M
F
D
W
F
D
----
Y
------
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
--
N
Y
L
P
Y
P
I
H
Q
----
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
----
S
DYELTYNLEKKRDERSV
K
-------------------------
S
-
T
---------
A
---------
V
R
V
V
D
F
G
S
A
T
F
D
--
H
E
--
H
H
S
T
I
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
------
Q
T
H
D
N
------
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
-
R
K
T
R
K
--
Q
K
Y
-
F
--------
Y
R
----------------------------------
G
-
R
L
-
D
W
--
D
----
E
--
N
T
S
A
G
R
Y
V
R
E
-----
N
C
K
P
L
R
R
Y
L
T
S
E
A
---
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
53.77
32%
-2
- C1 -
-
6FYI
1
CLK2_HUMAN
A:
[20-355]
------------------------------------------------------------------------------------------------
E
G
H
L
I
-
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
-
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
--
P
D
N
K
-----
N
L
C
V
Q
M
F
D
W
F
D
----
Y
------
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
--
N
Y
L
P
Y
P
I
H
Q
----
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
----
S
DYELTYNLEKKRDERSV
K
-------------------------
S
-
T
---------
A
---------
V
R
V
V
D
F
G
S
A
T
F
D
--
H
E
--
H
H
S
T
I
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
------
Q
T
H
D
N
------
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
-
R
K
T
R
K
--
Q
K
Y
-
F
--------
Y
R
----------------------------------
G
-
R
L
-
D
W
--
D
----
E
--
N
T
S
A
G
R
Y
V
R
E
-----
N
C
K
P
L
R
R
Y
L
T
S
E
A
---
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
53.55
32%
2
- C1 -
-
3NR9
1
CLK2_HUMAN
C:
[16-355]
--------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
-
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
-
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
--
P
D
N
K
-----
N
L
C
V
Q
M
F
D
W
F
D
----
Y
------
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
--
N
Y
L
P
Y
P
I
H
Q
----
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
----
S
DYELTYNLEKKRDERSV
K
-------------------------
S
-
T
---------
A
---------
V
R
V
V
D
F
G
S
A
T
F
D
--
H
E
--
H
H
S
T
I
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
------
Q
T
H
D
N
------
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
-
R
K
T
R
K
--
Q
K
Y
-
F
--------
Y
R
----------------------------------
G
-
R
L
-
D
W
--
D
----
E
--
N
T
S
A
G
R
Y
V
R
E
-----
N
C
K
P
L
R
R
Y
L
T
S
E
A
---
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
53.48
31%
-107
- C1 -
-
3RPR
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
53.19
32%
0
- C1 -
-
6FYK
1
CLK2_HUMAN
A:
[11-352]
--------------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
-
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
-
V
A
L
K
I
I
K
---
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
--
P
D
N
K
-----
N
L
C
V
Q
M
F
D
W
F
D
----
Y
------
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
--
N
Y
L
P
Y
P
I
H
Q
----
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
--------
N
----
S
DYELTYNLEKKRDERSV
K
-------------------------
S
-
T
---------
A
---------
V
R
V
V
D
F
G
S
A
T
F
D
--
H
E
--
H
H
S
T
I
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
------
Q
T
H
D
N
------
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
-
R
K
T
R
K
--
Q
K
Y
-
F
--------
Y
R
----------------------------------
G
-
R
L
-
D
W
--
D
----
E
--
N
T
S
A
G
R
Y
V
R
E
-----
N
C
K
P
L
R
R
Y
L
T
S
E
A
---
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
530
Blastp_CBE
53.06
31%
-99
- C1 -
-
3QTR
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
534
Blastp_CBE
53.01
31%
-88
- C1 -
-
3QQL
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
52.99
31%
-8
- C1 -
-
6KHD
1
CLK1_HUMAN
C:
[150-477]
----------------------------------------------------------------------------------------------------
I
C
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
-------------------------------------------------------------DERTLINPD
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
D
------
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
488
Blastp_CBE
52.73
31%
-104
- C1 -
-
3RAK
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
490
Blastp_CBE
52.72
31%
-105
- C1 -
-
3RAH
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
487
Blastp_CBE
52.62
31%
-100
- C1 -
-
3RAL
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
529
Blastp_CBE
51.89
31%
-101
- C1 -
-
3QTS
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
51.79
31%
-91
- C1 -
-
3S00
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
51.68
31%
-103
- C1 -
-
3R9N
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
51.64
31%
-101
- C1 -
-
3S1H
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
496
Blastp_CBE
51.28
31%
-87
- C1 -
-
3R8V
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
51.22
31%
-88
- C1 -
-
3R8P
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
51.19
31%
-86
- C1 -
-
6Q3C
1
CDK2_HUMAN
A:
[10-295]
--------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
-
Y
Y
-
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
51.05
31%
-89
- C1 -
-
3RJC
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
526
Blastp_CBE
50.93
31%
-85
- C1 -
-
3QTX
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
494
Blastp_CBE
50.76
31%
-84
- C1 -
-
3R9D
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
478
Blastp_CBE
50.75
31%
-90
- C1 -
-
3RNI
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
50.67
31%
-87
- C1 -
-
3RK5
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
50.62
33%
-49
- C1 -
-
6G33
1
CLK1_HUMAN
A:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
-----------------
K
-------------------------
I
-
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
----
H
H
S
---
T
L
V
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
538
Blastp_CBE
50.54
31%
-86
- C1 -
-
3QQG
2
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
524
Blastp_CBE
50.41
31%
-86
- C1 -
-
3QU0
5
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
495
Blastp_CBE
50.38
31%
-91
- C1 -
-
3R8Z
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
----THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
50.36
31%
-6
- C1 -
-
6KHD
1
CLK1_HUMAN
B:
[149-477]
---------------------------------------------------------------------------------------------------
L
I
C
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
----
P
---------------------------------------------
K
---------
R
DERTLINPD
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
--
H
H
S
T
L
---
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
D
------
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
516
Blastp_CBE
50.22
31%
-88
- C1 -
-
3QZG
2
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
535
Blastp_CBE
50.13
31%
-88
- C1 -
-
3QQK
6
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
536
Blastp_CBE
50.08
31%
-89
- C1 -
-
3QQJ
2
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
531
Blastp_CBE
49.74
31%
-88
- C1 -
-
3QTQ
2
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
528
Blastp_CBE
49.73
31%
-87
- C1 -
-
3QTU
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
49.67
31%
-87
- C1 -
-
3QTW
6
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
49.27
31%
-85
- C1 -
-
3RK9
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
49.27
31%
-99
- C1 -
-
6GUC
1
CDK2_HUMAN
A:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
-----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
517
Blastp_CBE
49.21
31%
-88
- C1 -
-
3QZF
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
484
Blastp_CBE
49.21
31%
-87
- C1 -
-
3RK7
2
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
518
Blastp_CBE
48.91
31%
-85
- C1 -
-
3QXP
2
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
461
Blastp_CBE
48.80
31%
-53
- C1 -
-
6Q48
2
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L--------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
--------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
48.70
33%
-46
- C1 -
-
2VAG
1
CLK1_HUMAN
A:
[5-332]
---------------------------------------------------------------------------------------------------
I
C
-
Q
S
G
D
V
L
S
-
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
I
V
K
---
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
--
P
N
S
T
-----
F
R
C
V
Q
M
L
E
W
F
E
----
H
------
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
----
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
K
L
T
--
H
T
D
L
K
P
E
N
I
L
F
---
V
QSDYTEAY
N
--------------------------------------------------
K
RDERTLINP
D
---------
I
K
V
V
D
F
G
S
A
T
Y
D
--
D
E
----
H
H
S
---
T
L
V
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
-
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
------
P
T
H
D
S
------
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
--
Q
K
T
R
-
K
R
K
Y
-
F
HH------
D
R
--
L
---
D
---
W
-----
D
E
H
-----------
S
S
--
A
-----
G
--
R
----
Y
--
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
---------------
D
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
482
Blastp_CBE
48.65
31%
-85
- C1 -
-
3RKB
2
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
574
HHSearch
48.60
33%
-39
- C1 -
-
4NM3
5
GSK3B_HUMAN
A:
[53-346]
------------------------------------------------------------------------------------------------------------
E
-
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
---
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
-
H
C
------------
N
I
V
R
L
R
Y
F
F
Y
----
S
SKKD--
E
V
----
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
SR
A
K
Q
T
L
P
V
I
Y
----
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
---
D
--------
P
----
D
-------------------------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
--
V
R
GE
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
-
A
T
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
-
R
E
M
N
P
-
N
Y
T
E
-
F
--------
K
------------------
F
P
-----------
Q
I
--
K
----
A
H
--
P
----
W
--
T
-------------------------
K
V
F
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
48.60
31%
-49
- C1 -
-
6Q4F
1
CDK2_HUMAN
A:
[8-295]
-----------------------------------------------------------------------------------------------------------
F
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
-
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
-
Y
Y
-
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
48.07
32%
-43
- C1 -
-
6H0U
3
GSK3B_HUMAN
B:
[56-345]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
48.03
31%
-95
- C1 -
-
2R3P
1
CDK2_HUMAN
A:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
-
Y
Y
-
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
356
Blastp_CBE
47.85
31%
-93
- C1 -
-
6GUE
1
CDK2_HUMAN
A:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
-----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
N
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
192
Blastp_CBE
47.72
33%
-12
- C1 -
-
4IJP
1
PRP4B_HUMAN
A:
[20-349]
--------------------------------------------------------------------------------------------------
Y
R
V
-
N
I
G
E
V
L
D
-
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
-
N
A
R
A
N
-
Q
-
E
-
V
A
V
K
I
I
R
---
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
--
P
D
D
K
-----
F
H
C
L
R
L
F
R
H
F
Y
----
H
------
K
Q
----
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G-
K
D
V
G
L
H
I
K
A
----
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
--
K
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
------------
N
----
E
-----------------
S
-------------------------
K
-
T
---------
I
---------
L
K
L
C
D
F
G
S
A
S
H
V
--
A
D
--
N
D
I
T
P
---
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
-
K
-
S
Y
-
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
------
P
G
K
T
N
------
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
-
R
K
G
V
F
-
K
D
Q
H
-
F
--------
D
Q
--
N
L
N
F
M
---
Y
IEVDK--------------
R
E
--
K
-
V
T
-
V
M
--
S
----
T
--
I
N
P
T
K
D
L
L
A
D
L
I
G
--
R
L
P
E
D
Q
R
K
K
V
H
---------
Q
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
47.43
33%
-12
- C1 -
-
4IJP
1
B:
[20-349]
--------------------------------------------------------------------------------------------------
Y
R
V
-
N
I
G
E
V
L
D
-
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
-
N
A
R
A
N
-
Q
-
E
-
V
A
V
K
I
I
R
---
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
--
P
D
D
K
-----
F
H
C
L
R
L
F
R
H
F
Y
----
H
------
K
Q
----
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G-
K
D
V
G
L
H
I
K
A
----
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
--
K
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
------------
N
----
E
-----------------
S
-------------------------
K
-
T
---------
I
---------
L
K
L
C
D
F
G
S
A
S
H
V
--
A
D
--
N
D
I
T
P
---
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
-
K
-
S
Y
-
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
------
P
G
K
T
N
------
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
-
R
K
G
V
F
-
K
D
Q
H
-
F
--------
D
Q
--
N
L
N
F
M
---
Y
IEVDK---------------
E
--
K
-
V
T
-
V
M
--
S
----
T
--
I
N
P
T
K
D
L
L
A
D
L
I
G
C
Q
R
L
P
E
D
Q
R
K
K
V
H
---------
Q
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
47.39
31%
-55
- C1 -
-
6Q4E
3
CDK2_HUMAN
A:
[8-295]
-----------------------------------------------------------------------------------------------------------
F
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
--------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
47.28
31%
-30
- C1 -
-
3QRU
2
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
47.09
31%
-90
- C1 -
-
2R3I
1
CDK2_HUMAN
A:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
-
Y
Y
-
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
571
HHSearch
46.85
34%
-25
- C1 -
-
1J1B
1
GSK3B_HUMAN
A:
[53-345]
------------------------------------------------------------------------------------------------------------
E
-
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
---
F
K
N
R
E
L
Q
I
M
R
K
L
D
-
H
C
------------
N
I
V
R
L
R
Y
F
F
Y
----
S
SGEKKD
E
V
----
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
SR
A
K
Q
T
L
P
V
I
Y
----
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
---
D
--------
P
----
D
-------------------------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
--
V
R
GE
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
-
A
T
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
-
R
E
M
N
P
N
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
-----
T
------------------------------------------------------------
K
V
F
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
46.85
33%
-11
- C1 -
-
4IIR
1
B:
[20-349]
--------------------------------------------------------------------------------------------------
Y
R
V
-
N
I
G
E
V
L
D
-
K
R
Y
N
V
Y
G
Y
T
G
Q
---
S
N
V
V
R
A
R
D
-
N
A
R
A
N
-
Q
-
E
-
V
A
V
K
I
I
R
---
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
--
P
D
D
K
-----
F
H
C
L
R
L
F
R
H
F
Y
----
H
------
K
Q
----
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G-
K
D
V
G
L
H
I
K
A
----
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
--
K
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
------------
N
----
E
-----------------
S
-------------------------
K
-
T
---------
I
---------
L
K
L
C
D
F
G
S
A
S
H
V
--
A
D
--
N
D
I
T
P
---
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
-
K
-
S
Y
-
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
------
P
G
K
T
N
------
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
-
R
K
G
V
F
-
K
D
Q
H
-
F
--------
D
Q
--
N
L
N
F
M
---
Y
IEVDK--------------
R
E
--
K
-
V
T
-
V
M
--
S
----
T
--
I
N
P
T
K
D
L
L
A
D
L
I
G
--
R
L
P
E
D
Q
R
K
K
V
H
---------
Q
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
46.57
31%
-32
- C1 -
-
1H8F
2
GSK3B_HUMAN
A:
[22-311]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
G
K
A
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
--------------------------------------------
T
R
E
-----------
Q
I
--
R
-
E
M
-
N
P
--
N
----
Y
----------
T
E
F
A
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
E
A
I
----
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
46.46
32%
-47
- C1 -
-
5F95
1
GSK3B_HUMAN
A:
[21-310]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
----
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
46.46
32%
-44
- C1 -
-
4NM0
6
GSK3B_HUMAN
A:
[56-345]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
46.46
32%
-45
- C1 -
-
3I4B
1
GSK3B_HUMAN
B:
[50-339]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
46.39
31%
-35
- C1 -
-
6Q4C
1
CDK2_HUMAN
A:
[8-295]
-----------------------------------------------------------------------------------------------------------
F
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
46.39
31%
-34
- C1 -
-
1H8F
2
GSK3B_HUMAN
B:
[22-311]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
G
K
A
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
--------------------------------------------
T
R
E
-----------
Q
I
--
R
-
E
M
-
N
P
--
N
----
Y
----------
T
E
F
A
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
E
A
I
----
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
46.29
31%
-37
- C1 -
-
2IW9
1
CDK2_HUMAN
A:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
46.28
31%
-90
- C1 -
-
2R3O
1
CDK2_HUMAN
A:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
-
Y
Y
-
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
46.23
32%
-45
- C1 -
-
4ACC
3
GSK3B_HUMAN
A:
[101-390]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
323
Blastp_CBE
46.20
32%
-44
- C1 -
-
5F94
1
GSK3B_HUMAN
A:
[21-310]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
46.18
32%
-44
- C1 -
-
1J1B
1
GSK3B_HUMAN
B:
[56-345]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
46.17
32%
-43
- C1 -
-
3PUP
1
GSK3B_HUMAN
A:
[56-345]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
-
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
-
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
46.17
32%
-42
- C1 -
-
3PUP
1
GSK3B_HUMAN
B:
[56-345]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
-
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
-
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
46.06
32%
-45
- C1 -
-
4ACD
1
GSK3B_HUMAN
A:
[101-390]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
45.94
32%
-43
- C1 -
-
6H0U
4
GSK3B_HUMAN
A:
[56-345]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
45.93
32%
-46
- C1 -
-
1J1C
1
GSK3B_HUMAN
A:
[56-345]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
45.90
32%
-44
- C1 -
-
4ACD
1
GSK3B_HUMAN
B:
[101-390]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
218
Blastp_CBE
45.80
35%
-139
- C1 -
-
4BGQ
3
CDKL5_HUMAN
A:
[11-236]
------------------------------------------------------------------------------------------------------------
M
-
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
-
K
-
E
T
H
-
E
-
I
-
V
A
I
K
K
F
K
----------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
--
Q
E
--------
N
I
V
E
L
K
E
A
F
R
----
R
------
R
G
----
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
M
--
P
-
N
G
V
P
P
E
K
----
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
--
I
V
H
R
D
I
K
P
E
N
L
L
I
---
S
--------
H
------------------------------------------------
N
-
D
---------
V
---------
L
K
L
C
D
F
G
F
A
R
N
L
--
S
E
------------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
-
P
Y
-
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
------
P
G
E
S
E
------
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
45.72
32%
-46
- C1 -
-
1J1B
1
GSK3B_HUMAN
A:
[56-345]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
349
Blastp_CBE
45.71
31%
-36
- C1 -
-
2IW6
1
CDK2_HUMAN
A:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
45.40
32%
-34
- C1 -
-
2JLD
1
GSK3B_HUMAN
B:
[56-345]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
-
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
291
Blastp_CBE
45.27
32%
-44
- C1 -
-
4ACG
1
GSK3B_HUMAN
B:
[101-390]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
281
Blastp_CBE
45.27
32%
-43
- C1 -
-
4PTE
1
GSK3B_HUMAN
A:
[77-366]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
--
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
----
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
45.23
31%
-33
- C1 -
-
6Q4K
3
CDK2_HUMAN
A:
[8-295]
-----------------------------------------------------------------------------------------------------------
F
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
-
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
45.19
32%
-41
- C1 -
-
3M1S
1
GSK3B_HUMAN
A:
[56-345]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
-
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
--K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
45.18
32%
-43
- C1 -
-
4ACG
1
GSK3B_HUMAN
A:
[101-390]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
45.15
31%
-74
- C1 -
-
2R3M
1
CDK2_HUMAN
A:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
-------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
-
Y
Y
-
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
45.13
32%
-41
- C1 -
-
4EOM
1
CDK2_HUMAN
A:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L--
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
E
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
45.12
32%
-42
- C1 -
-
2JLD
1
GSK3B_HUMAN
A:
[56-345]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
-
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
-
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
269
Blastp_CBE
45.01
32%
-49
- C1 -
-
6GJO
1
GSK3B_HUMAN
A:
[50-339]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
194
Blastp_CBE
44.97
33%
-5
- C1 -
-
4IIR
1
PRP4B_HUMAN
A:
[20-349]
--------------------------------------------------------------------------------------------------
Y
R
V
-
N
I
G
E
V
L
D
-
K
R
Y
N
V
Y
G
Y
T
G
Q
G
--
S
N
V
V
R
A
R
D
-
N
A
R
A
N
-
Q
-
E
-
V
A
V
K
I
I
R
---
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
--
P
D
D
K
-----
F
H
C
L
R
L
F
R
H
F
Y
----
H
------
K
Q
----
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G-
K
D
V
G
L
H
I
K
A
----
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
--
K
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
------------
N
----
E
-----------------
S
-------------------------
K
-
T
---------
I
---------
L
K
L
C
D
F
G
S
A
S
H
V
--
A
D
--
N
D
I
T
P
---
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
-
K
-
S
Y
-
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
------
P
G
K
T
N
------
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
-
R
K
G
V
F
-
K
D
Q
H
-
F
--------
D
Q
--
N
L
N
F
M
---
Y
IE-----------------
R
E
--
K
-
V
T
-
V
M
--
S
----
T
--
I
N
P
T
K
D
L
L
A
D
L
I
G
----
P
E
D
Q
R
K
K
V
H
---------
Q
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
220
Blastp_CBE
44.95
32%
-39
- C1 -
-
4EOJ
1
CDK2_HUMAN
A:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
470
Blastp_CBE
44.88
31%
-33
- C1 -
-
3S0O
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
--
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
44.85
32%
-10
- C1 -
-
6PK6
1
A:
[14-350]
-------------------------------------------------------------------------------------------
W
T
D
A
E
G
Y
Y
R
V
-
N
I
G
E
V
L
D
-
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
-
N
A
R
A
N
-
Q
-
E
-
V
A
V
K
I
I
R
---
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
--
P
D
D
K
-----
F
H
C
L
R
L
F
R
H
F
Y
----
H
------
K
Q
----
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G-
K
D
V
G
L
H
I
K
A
----
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
--
K
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
------------
N
----
E
-----------------
S
-------------------------
K
-
T
---------
I
---------
L
K
L
C
D
F
G
S
A
S
H
V
--
A
D
--
N
D
I
T
P
---
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
-
K
-
S
Y
-
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
------
P
G
K
T
N
------
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
-
R
K
G
V
F
-
K
D
Q
H
-
F
--------
D
Q
--
N
L
N
F
M
---
Y
IEVDK
V
T
E
-----------
R
E
--
K
-
V
T
-
V
M
--
S
----
T
--
I
N
P
T
K
D
L
L
A
D
L
I
G
C
Q
R
L
P
E
D
Q
R
K
K
V
H
---------
Q
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
44.84
32%
-42
- C1 -
-
4NM5
5
GSK3B_HUMAN
A:
[44-333]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
44.78
32%
-44
- C1 -
-
4B7T
1
GSK3B_HUMAN
A:
[22-311]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
44.70
32%
-36
- C1 -
-
4EOL
1
CDK2_HUMAN
A:
[4-290]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L--
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
S
---
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
44.63
32%
-38
- C1 -
-
3M1S
1
GSK3B_HUMAN
B:
[56-345]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
-
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
44.61
32%
-47
- C1 -
-
1Q3W
1
GSK3B_HUMAN
A:
[60-349]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
----
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-----K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
44.53
31%
-33
- C1 -
-
4GCJ
5
CDK2_HUMAN
A:
[8-295]
-----------------------------------------------------------------------------------------------------------
F
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
283
Blastp_CBE
44.52
32%
-48
- C1 -
-
4PTC
1
GSK3B_HUMAN
A:
[77-366]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
----
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
44.51
31%
-30
- C1 -
-
6Q4B
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
44.45
32%
-40
- C1 -
-
4NU1
4
GSK3B_MOUSE
A:
[56-345]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
--
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
44.43
33%
-8
- C1 -
-
4IFC
1
B:
[20-349]
--------------------------------------------------------------------------------------------------
Y
R
V
-
N
I
G
E
V
L
D
-
K
R
Y
N
V
Y
G
Y
T
G
Q
-
V
F
S
N
V
V
R
A
R
D
-
N
A
R
A
N
-
Q
-
E
-
V
A
V
K
I
I
R
---
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
--
P
D
D
K
-----
F
H
C
L
R
L
F
R
H
F
Y
----
H
------
K
Q
----
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G-
K
D
V
G
L
H
I
K
A
----
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
--
K
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
------------
N
----
E
-----------------
S
-------------------------
K
-
T
---------
I
---------
L
K
L
C
D
F
G
S
A
S
H
V
--
A
D
--
N
D
I
T
P
---
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
-
K
-
S
Y
-
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
------
P
G
K
T
N
------
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
-
R
K
G
V
F
-
K
D
Q
H
-
F
--------
D
Q
--
N
L
N
F
M
---
Y
IEVDK--------------
R
E
--
K
-
V
T
-
V
M
--
S
----
T
--
I
N
P
T
K
D
L
L
A
D
L
I
G
--
R
L
P
E
D
Q
R
K
K
V
H
---------
Q
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
44.42
31%
-30
- C1 -
-
4EZ7
7
CDK2_HUMAN
A:
[8-295]
-----------------------------------------------------------------------------------------------------------
F
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
235
Blastp_CBE
44.39
32%
-38
- C1 -
-
3Q3B
1
GSK3B_HUMAN
B:
[60-349]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
---
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
------K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
299
Blastp_CBE
44.38
32%
-40
- C1 -
-
2O5K
1
GSK3B_HUMAN
A:
[35-324]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
44.32
32%
-41
- C1 -
-
3I4B
1
GSK3B_HUMAN
A:
[50-339]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
44.27
32%
-43
- C1 -
-
1PYX
1
GSK3B_HUMAN
A:
[58-347]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
-----
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
-----
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
44.18
31%
-32
- C1 -
-
6GUH
3
CDK2_HUMAN
A:
[8-295]
-----------------------------------------------------------------------------------------------------------
F
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L--------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
------------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
207
Blastp_CBE
44.17
33%
-43
- C1 -
-
1Q99
2
SKY1_YEAST
B:
[20-275]
---------------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
-
M
-
V
N
N
-
T
-
H
-
V
A
M
K
I
V
R
---
G
D
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
R
V
N
D
A
D
--
N
T
K
E
DSMGA
N
H
I
L
K
L
L
D
H
F
N
----
H
------
K
G
PNGV
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
Y
--
E
H
R
G
I
P
L
I
Y
----
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
H
R
-
R
C
G
I
I
H
T
D
I
K
P
E
N
V
L
M
EIV
D
--------
S
----
P
-----------------
E
-------------------------
N
L
I
---------
Q
---------
I
K
I
A
D
L
G
N
A
C
W
Y
--
D
E
--
H
Y
T
N
S
---
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
-
A
-
P
W
-
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
D
F
L
F
EPDEGH
S
Y
T
K
D
------
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
-
R
N
G
K
Y
-
T
R
T
F
-
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
44.15
32%
-43
- C1 -
-
4NM7
5
GSK3B_HUMAN
A:
[44-333]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
--
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
279
Blastp_CBE
44.10
32%
-40
- C1 -
-
4PTG
1
GSK3B_HUMAN
A:
[77-366]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
------
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
---------
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
44.08
33%
-5
- C1 -
-
4IFC
1
PRP4B_HUMAN
A:
[20-349]
--------------------------------------------------------------------------------------------------
Y
R
V
-
N
I
G
E
V
L
D
-
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
-
N
A
R
A
N
-
Q
-
E
-
V
A
V
K
I
I
R
---
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
--
P
D
D
K
-----
F
H
C
L
R
L
F
R
H
F
Y
----
H
------
K
Q
----
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G-
K
D
V
G
L
H
I
K
A
----
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
--
K
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
------------
N
----
E
-----------------
S
-------------------------
K
-
T
---------
I
---------
L
K
L
C
D
F
G
S
A
S
H
V
--
A
D
--
N
D
I
T
P
---
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
-
K
-
S
Y
-
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
------
P
G
K
T
N
------
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
-
R
K
G
V
F
-
K
D
Q
H
-
F
--------
D
Q
--
N
L
N
F
M
---
Y
IE-----------------
R
E
--
K
-
V
T
-
V
M
--
S
----
T
--
I
N
P
T
K
D
L
L
A
D
L
I
G
----
P
E
D
Q
R
K
K
V
H
---------
Q
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
44.01
32%
-44
- C1 -
-
4NM3
5
GSK3B_HUMAN
A:
[56-345]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
--
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
399
Blastp_CBE
43.97
31%
-33
- C1 -
-
1E9H
1
CDK2_HUMAN
A:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
341
Blastp_CBE
43.93
31%
-36
- C1 -
-
1OIU
1
CDK2_HUMAN
A:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
43.91
32%
-48
- C1 -
-
4PTC
1
GSK3B_HUMAN
B:
[77-366]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
----
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
301
Blastp_CBE
43.85
31%
-41
- C1 -
-
4EOO
1
CDK2_HUMAN
A:
[3-289]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
E
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
43.82
31%
-37
- C1 -
-
6Q4G
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
E
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LD------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
43.82
32%
-31
- C1 -
-
4EOK
1
CDK2_HUMAN
C:
[4-290]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
43.80
32%
-44
- C1 -
-
1PYX
1
GSK3B_HUMAN
B:
[58-347]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
-----
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
-------
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
43.73
31%
-28
- C1 -
-
6Q4A
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LD------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
-
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
401
Blastp_CBE
43.70
31%
-38
- C1 -
-
4EOR
1
CDK2_HUMAN
A:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
43.65
31%
-39
- C1 -
-
3TNW
1
CDK2_HUMAN
A:
[3-289]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
43.65
32%
-27
- C1 -
-
4EOI
1
CDK2_HUMAN
C:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
D
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
E
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
43.64
32%
-38
- C1 -
-
5F95
1
GSK3B_HUMAN
B:
[21-310]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
E
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-----------------------
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
43.53
32%
-29
- C1 -
-
4EOL
1
CDK2_HUMAN
C:
[4-290]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
43.46
32%
-42
- C1 -
-
1Q3W
1
GSK3B_HUMAN
B:
[60-349]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
---
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
------K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
228
Blastp_CBE
43.45
32%
-31
- C1 -
-
4EON
1
CDK2_HUMAN
A:
[3-289]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
E
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
43.34
32%
-32
- C1 -
-
4EOI
2
CDK2_HUMAN
A:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
D
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
E
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
43.33
31%
-29
- C1 -
-
4BCO
1
CDK2_HUMAN
A:
[3-289]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
224
Blastp_CBE
43.32
32%
-39
- C1 -
-
4EOK
1
CDK2_HUMAN
A:
[4-290]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
43.23
33%
-45
- C1 -
-
1Q8Y
1
?
B:
[20-275]
---------------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
---
F
S
T
V
W
L
A
K
D
-
M
-
V
N
N
-
T
-
H
-
V
A
M
K
I
V
R
---
G
D
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
R
V
N
D
A
D
--
N
T
K
E
DSMGA
N
H
I
L
K
L
L
D
H
F
N
----
H
------
K
G
PNGV
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
Y
--
E
H
R
G
I
P
L
I
Y
----
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
H
R
-
R
C
G
I
I
H
T
D
I
K
P
E
N
V
L
M
EIV
D
--------
S
----
P
-----------------
E
-------------------------
N
L
I
---------
Q
---------
I
K
I
A
D
L
G
N
A
C
W
Y
--
D
E
--
H
Y
T
N
S
---
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
-
A
-
P
W
-
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
D
F
L
F
EPDEGH
S
Y
T
K
D
------
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
-
R
N
G
K
Y
-
T
R
T
F
-
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
335
Blastp_CBE
43.22
31%
-40
- C1 -
-
6GUB
1
CDK2_HUMAN
A:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
43.21
31%
-31
- C1 -
-
2CCH
3
CDK2_HUMAN
A:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
420
Blastp_CBE
43.13
31%
-32
- C1 -
-
1P5E
1
CDK2_HUMAN
A:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
43.10
31%
-27
- C1 -
-
6Q3B
1
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L-------
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
----------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
42.92
32%
-47
- C1 -
-
3Q3B
1
GSK3B_HUMAN
A:
[60-349]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
----
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-----K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
42.90
31%
-38
- C1 -
-
3MY5
3
CDK2_HUMAN
A:
[3-289]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
402
Blastp_CBE
42.88
31%
-29
- C1 -
-
6GVA
3
CDK2_HUMAN
A:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
--
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
339
Blastp_CBE
42.87
31%
-40
- C1 -
-
1OIY
1
CDK2_HUMAN
A:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
42.84
32%
-26
- C1 -
-
4EON
1
CDK2_HUMAN
C:
[3-289]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
E
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
268
Blastp_CBE
42.82
32%
-48
- C1 -
-
6GJO
1
GSK3B_HUMAN
B:
[50-339]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
------
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
F
K
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
351
Blastp_CBE
42.71
31%
-37
- C1 -
-
4EOQ
1
CDK2_HUMAN
A:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
42.66
32%
-34
- C1 -
-
1Q3D
1
GSK3B_HUMAN
A:
[60-349]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
------
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
-------
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
42.63
31%
-36
- C1 -
-
3DDP
1
CDK2_HUMAN
C:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
42.59
31%
-33
- C1 -
-
6Q4J
2
CDK2_HUMAN
A:
[8-295]
-----------------------------------------------------------------------------------------------------------
F
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L--------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
42.59
31%
-30
- C1 -
-
5CYI
1
CDK2_HUMAN
A:
[6-292]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
42.59
32%
-39
- C1 -
-
4IQ6
1
GSK3B_HUMAN
B:
[62-351]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
------
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
---------
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
317
Blastp_CBE
42.55
31%
-31
- C1 -
-
4CFV
1
CDK2_HUMAN
A:
[6-292]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
270
Blastp_CBE
42.54
32%
-34
- C1 -
-
3L1S
1
GSK3B_HUMAN
B:
[50-339]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
--
K
K
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
-----------------------------
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
42.48
31%
-104
- C1 -
-
2R3N
1
CDK2_HUMAN
A:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
-
Y
Y
-
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
435
Blastp_CBE
42.46
31%
-33
- C1 -
-
2UZL
1
CDK2_HUMAN
A:
[1-287]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
42.30
31%
-34
- C1 -
-
2CCI
1
CDK2_HUMAN
C:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
42.24
31%
-26
- C1 -
-
2UZB
1
CDK2_HUMAN
A:
[1-287]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
418
Blastp_CBE
42.21
31%
-28
- C1 -
-
1QMZ
1
CDK2_HUMAN
A:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
42.21
31%
-35
- C1 -
-
1OGU
1
CDK2_HUMAN
A:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
42.15
31%
-24
- C1 -
-
3QHR
6
CDK2_HUMAN
A:
[3-289]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
369
Blastp_CBE
42.16
31%
-30
- C1 -
-
1H1S
1
CDK2_HUMAN
A:
[6-292]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
342
Blastp_CBE
42.16
31%
-31
- C1 -
-
1OI9
1
CDK2_HUMAN
C:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
343
Blastp_CBE
42.15
31%
-17
- C1 -
-
1OI9
1
CDK2_HUMAN
A:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LT-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
373
Blastp_CBE
42.13
31%
-28
- C1 -
-
1H1Q
1
CDK2_HUMAN
A:
[6-292]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
42.09
31%
-28
- C1 -
-
2IW6
1
CDK2_HUMAN
C:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
332
Blastp_CBE
42.10
31%
-31
- C1 -
-
6GUC
1
CDK2_HUMAN
C:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
237
Blastp_CBE
42.09
32%
-37
- C1 -
-
1Q4L
1
GSK3B_HUMAN
B:
[60-349]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
---
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
-
Y
T
E
-------------------
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
42.05
31%
-29
- C1 -
-
1PKD
1
CDK2_HUMAN
A:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
42.02
31%
-18
- C1 -
-
3BHV
2
CDK2_HUMAN
A:
[3-289]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LD--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
42.03
31%
-23
- C1 -
-
4I3Z
4
CDK2_HUMAN
A:
[1-287]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
42.02
32%
-32
- C1 -
-
1Q3D
1
GSK3B_HUMAN
B:
[60-349]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
----
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
-------
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
421
Blastp_CBE
42.01
31%
-26
- C1 -
-
1GY3
2
CDK2_HUMAN
C:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
408
Blastp_CBE
41.98
31%
-21
- C1 -
-
3DDQ
1
CDK2_HUMAN
A:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LD--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
41.99
31%
-24
- C1 -
-
4I3Z
3
CDK2_HUMAN
C:
[1-287]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
41.98
31%
-28
- C1 -
-
4CFW
1
CDK2_HUMAN
A:
[6-292]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
358
Blastp_CBE
41.96
31%
-31
- C1 -
-
5NEV
1
CDK2_HUMAN
A:
[6-292]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
374
Blastp_CBE
41.94
31%
-28
- C1 -
-
1H1P
1
CDK2_HUMAN
C:
[6-292]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
41.95
31%
-27
- C1 -
-
4BCN
1
CDK2_HUMAN
C:
[3-289]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
41.94
31%
-30
- C1 -
-
5NEV
1
?
C:
[6-292]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
41.93
32%
-44
- C1 -
-
4PTG
1
GSK3B_HUMAN
B:
[77-366]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
----
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
------------------------
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
277
Blastp_CBE
41.91
31%
-21
- C1 -
-
4EOP
1
CDK2_HUMAN
A:
[4-290]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LD--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
E
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
231
Blastp_CBE
41.89
32%
-34
- C1 -
-
3DU8
1
GSK3B_HUMAN
B:
[58-347]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
------
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
-------
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
276
Blastp_CBE
41.87
31%
-23
- C1 -
-
4EOP
1
CDK2_HUMAN
C:
[4-290]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
E
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
41.86
32%
-34
- C1 -
-
3DU8
1
GSK3B_HUMAN
A:
[58-347]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
------
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
-------
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
41.85
31%
-32
- C1 -
-
1H1P
1
CDK2_HUMAN
A:
[6-292]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
41.83
31%
-26
- C1 -
-
1PKD
1
CDK2_HUMAN
C:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
41.77
31%
-18
- C1 -
-
3DOG
1
CDK2_HUMAN
A:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LT-
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
41.77
31%
-37
- C1 -
-
4CFN
1
CDK2_HUMAN
A:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
41.75
31%
-27
* C1 *
-
2CCH
1
CDK2_HUMAN
C:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
41.61
31%
-32
- C1 -
-
2CCI
1
CDK2_HUMAN
A:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
41.58
31%
-29
- C1 -
-
2UZD
1
CDK2_HUMAN
A:
[1-287]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
41.56
31%
-28
- C1 -
-
6GUE
1
CDK2_HUMAN
C:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
------
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-----
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
41.45
31%
-26
- C1 -
-
1QMZ
1
CDK2_HUMAN
C:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
41.46
31%
-29
- C1 -
-
1GY3
1
CDK2_HUMAN
A:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
41.45
32%
-33
- C1 -
-
1Q4L
1
GSK3B_HUMAN
A:
[60-349]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
G
---
D
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
--------
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
425
Blastp_CBE
41.44
31%
-25
- C1 -
-
3QHR
2
CDK2_HUMAN
C:
[3-289]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
41.43
31%
-31
- C1 -
-
1H1S
1
CDK2_HUMAN
C:
[6-292]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
41.38
31%
-35
- C1 -
-
2UZB
1
CDK2_HUMAN
C:
[1-287]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
41.36
31%
-26
- C1 -
-
4CFX
1
CDK2_HUMAN
A:
[6-292]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
41.32
31%
-21
- C1 -
-
3BHU
1
CDK2_HUMAN
A:
[3-289]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LD--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
41.30
31%
-25
- C1 -
-
3TNW
1
CDK2_HUMAN
C:
[3-289]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
41.29
33%
-38
- C1 -
-
1Q97
1
?
A:
[20-277]
---------------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
-
M
-
V
N
N
-
T
-
H
-
V
A
M
K
I
V
R
---
G
D
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
R
V
N
D
A
D
--
N
T
K
E
DSMGA
N
H
I
L
K
L
L
D
H
F
N
----
H
------
K
G
PNGV
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
Y
--
E
H
R
G
I
P
L
I
Y
----
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
H
R
-
R
C
G
I
I
H
T
D
I
K
P
E
N
V
L
M
EIV
D
--------
S
----
P
-----------------
E
-------------------------
N
L
I
---------
Q
---------
I
K
I
A
D
L
G
N
A
C
W
Y
--
D
E
--
H
Y
T
N
S
---
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
-
A
-
P
W
-
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
D
F
L
F
---------
K
D
------
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
-
R
N
G
K
Y
-
T
R
T
F
-
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
41.27
31%
-28
- C1 -
-
4BCP
1
CDK2_HUMAN
A:
[3-289]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
41.26
31%
-27
- C1 -
-
3QHW
3
CDK2_HUMAN
C:
[3-289]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
41.23
31%
-24
- C1 -
-
1H1R
1
CDK2_HUMAN
A:
[6-292]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
359
Blastp_CBE
41.20
31%
-29
- C1 -
-
5CYI
1
CDK2_HUMAN
C:
[6-292]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
41.12
31%
-24
- C1 -
-
3QHW
2
CDK2_HUMAN
A:
[3-289]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
41.12
31%
-30
- C1 -
-
3DDP
1
CDK2_HUMAN
A:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
300
Blastp_CBE
41.07
31%
-22
- C1 -
-
4EOO
1
CDK2_HUMAN
C:
[3-289]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
E
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
41.06
31%
-29
- C1 -
-
2UZE
1
CDK2_HUMAN
C:
[1-287]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
41.03
31%
-27
- C1 -
-
1JST
1
CDK2_HUMAN
A:
[1-287]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
40.95
31%
-34
- C1 -
-
1P5E
1
CDK2_HUMAN
C:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
40.92
31%
-27
- C1 -
-
1JST
1
CDK2_HUMAN
C:
[1-287]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
40.91
31%
-21
- C1 -
-
3BHT
1
CDK2_HUMAN
A:
[3-289]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LD--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
40.87
31%
-27
- C1 -
-
2UZD
1
CDK2_HUMAN
C:
[1-287]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
404
Blastp_CBE
40.87
31%
-29
- C1 -
-
5L2W
2
CDK2_HUMAN
A:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
403
Blastp_CBE
40.87
31%
-23
- C1 -
-
5LMK
1
CDK2_HUMAN
A:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LD--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
40.87
31%
-29
- C1 -
-
6GUB
1
?
C:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
---------------------------------------
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
433
Blastp_CBE
40.86
31%
-23
- C1 -
-
4II5
2
CDK2_HUMAN
A:
[1-287]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
370
Blastp_CBE
40.80
31%
-29
- C1 -
-
1H1R
1
CDK2_HUMAN
C:
[6-292]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
40.71
31%
-28
- C1 -
-
6GUF
1
CDK2_HUMAN
C:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
398
Blastp_CBE
40.64
31%
-28
- C1 -
-
1E9H
1
CDK2_HUMAN
C:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
40.61
33%
-39
- C1 -
-
1Q8Y
1
?
A:
[20-277]
---------------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
-
M
-
V
N
N
-
T
-
H
-
V
A
M
K
I
V
R
---
G
D
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
R
V
N
D
A
D
--
N
T
K
E
DSMGA
N
H
I
L
K
L
L
D
H
F
N
----
H
------
K
G
PNGV
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
Y
--
E
H
R
G
I
P
L
I
Y
----
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
H
R
-
R
C
G
I
I
H
T
D
I
K
P
E
N
V
L
M
EIV
D
--------
S
----
P
-----------------
E
-------------------------
N
L
I
---------
Q
---------
I
K
I
A
D
L
G
N
A
C
W
Y
--
D
E
--
H
Y
T
N
S
---
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
-
A
-
P
W
-
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
D
F
L
F
---------
K
D
------
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
-
R
N
G
K
Y
-
T
R
T
F
-
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
40.57
31%
-18
- C1 -
-
4EOS
1
CDK2_HUMAN
A:
[4-290]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LD---
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
372
Blastp_CBE
40.54
31%
-28
- C1 -
-
1H1Q
1
CDK2_HUMAN
C:
[6-292]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
40.53
31%
-27
- C1 -
-
4CFW
1
CDK2_HUMAN
C:
[6-292]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
40.49
31%
-25
- C1 -
-
2UZE
1
CDK2_HUMAN
A:
[1-287]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
338
Blastp_CBE
40.46
31%
-25
- C1 -
-
1OIY
1
CDK2_HUMAN
C:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
40.45
31%
-26
- C1 -
-
4EOS
1
CDK2_HUMAN
C:
[4-290]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
382
Blastp_CBE
40.41
31%
-21
- C1 -
-
4BCN
1
CDK2_HUMAN
A:
[3-289]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LD--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
40.37
31%
-27
- C1 -
-
2C6T
1
CDK2_HUMAN
C:
[1-287]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
40.37
31%
-41
- C1 -
-
3BHV
1
CDK2_HUMAN
C:
[3-289]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
-------------------------------------------------------------------------------
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
432
Blastp_CBE
40.26
31%
-21
- C1 -
-
4II5
3
CDK2_HUMAN
C:
[1-287]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
40.27
31%
-20
- C1 -
-
2C6T
1
CDK2_HUMAN
A:
[1-287]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
40.26
32%
-26
- C1 -
-
4EOM
1
CDK2_HUMAN
C:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
E
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
-----------------------------------------------------------------------
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
40.23
31%
-33
- C1 -
-
2IW9
1
CDK2_HUMAN
C:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
----------------------------------------------------------------------------------------------
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
219
Blastp_CBE
40.18
32%
-35
- C1 -
-
4EOJ
1
CDK2_HUMAN
C:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
---------------------------------------------------------------
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
40.14
32%
-36
- C1 -
-
4IQ6
1
GSK3B_HUMAN
A:
[62-351]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
------------
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
VR
G
E
--
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
-------------------------
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
434
Blastp_CBE
40.12
31%
-29
- C1 -
-
2UZL
1
CDK2_HUMAN
C:
[1-287]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
40.07
31%
-33
- C1 -
-
4CFU
1
CDK2_HUMAN
C:
[6-292]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
-------------------------------------------------------------------------------
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
40.02
31%
-41
- C1 -
-
3BHT
1
CDK2_HUMAN
C:
[3-289]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
-------------------------------------------------------------------------------
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
39.86
31%
-16
- C1 -
-
4CFU
1
CDK2_HUMAN
A:
[6-292]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LD--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
39.50
31%
-35
- C1 -
-
1OGU
1
CDK2_HUMAN
C:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
-------------------------------------------------------------------------------
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
353
Blastp_CBE
39.46
31%
-32
- C1 -
-
4BCQ
1
CDK2_HUMAN
A:
[4-290]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
208
Blastp_CBE
39.45
33%
-30
- C1 -
-
1Q99
2
SKY1_YEAST
A:
[20-277]
---------------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
-
M
-
V
N
N
-
T
-
H
-
V
A
M
K
I
V
R
---
G
D
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
R
V
N
D
A
D
--
N
T
K
E
DSMGA
N
H
I
L
K
L
L
D
H
F
N
----
H
------
K
G
PNGV
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
Y
--
E
H
R
G
I
P
L
I
Y
----
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
H
R
-
R
C
G
I
I
H
T
D
I
K
P
E
N
V
L
M
EIV
D
--------
S
----
P
-----------------
E
-------------------------
N
L
I
---------
Q
---------
I
K
I
A
D
L
G
N
A
C
W
Y
--
D
E
--
H
Y
T
N
S
---
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
-
A
-
P
W
-
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
D
F
L
F
E-------
T
K
D
------
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
-
R
N
G
K
Y
-
T
R
T
F
-
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
39.23
31%
-37
- C1 -
-
4ERW
17
CDK2_HUMAN
A:
[9-295]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
L-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
--
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
-
Y
Y
-
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
38.91
31%
-36
- C1 -
-
3BHU
1
CDK2_HUMAN
C:
[3-289]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
-------------------------------------------------------------------------------
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
340
Blastp_CBE
38.62
31%
-38
- C1 -
-
1OIU
1
CDK2_HUMAN
C:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
-------------------------------------------------------------------------------------------------
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
38.58
31%
-22
- C1 -
-
4CFX
1
CDK2_HUMAN
C:
[6-292]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
37.99
31%
-33
- C1 -
-
3MY5
1
CDK2_HUMAN
C:
[3-289]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
------------------------------------------------------------------------------------------------
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
37.96
31%
-35
- C1 -
-
4BCP
1
CDK2_HUMAN
C:
[3-289]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
-------------------------------------------------------------------------------
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
350
Blastp_CBE
37.92
31%
-30
- C1 -
-
4EOQ
1
CDK2_HUMAN
C:
[5-291]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
-----------------------------------------------------------------------
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
395
Blastp_CBE
37.71
31%
-37
- C1 -
-
5LMK
1
?
C:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
-------------------------------------------------------------------------------------------------
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
449
Blastp_CBE
37.60
31%
-35
- C1 -
-
1FQ1
1
CDK2_HUMAN
B:
[1-287]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
-
P
G
V
T
S
-
M
P
D
Y
-
K
--------
P
S
--
F
P
------------------------------
K
-
W
A
-
R
Q
--
D
----
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
400
Blastp_CBE
37.57
31%
-36
- C1 -
-
4EOR
1
CDK2_HUMAN
C:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
---------------------------------------------------------------------------
F
--
S
-------------
K
V
V
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
405
Blastp_CBE
37.54
31%
-37
- C1 -
-
3DOG
1
CDK2_HUMAN
C:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
------------------------------------------------------------------------------------------------
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
407
Blastp_CBE
36.33
31%
-34
- C1 -
-
3DDQ
1
CDK2_HUMAN
C:
[2-288]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
-------------------------------------------------------------------------------------------------
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
36.17
31%
-38
- C1 -
-
4CFV
1
CDK2_HUMAN
C:
[6-292]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
------------------------------------------------------------------------------------------------
P
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
35.78
31%
-43
- C1 -
-
5HLP
1
GSK3B_HUMAN
A:
[60-349]
----------------------------------------------------------------------------------------------------------------
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
-
V
A
I
K
K
V
L
---
Q
D
K
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
--
L
R
Y
F
-----
F
Y
S
S
-----
E
V
----
Y
------
L
N
-------
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
Y
S
R
A
K
Q
T
L
PVIY
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
--
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
------------
D
----
P
-----------------
D
-------------------------
T
-
A
---------
V
---------
L
K
L
C
D
F
G
S
A
K
Q
L
--
V
R
G-
E
P
N
V
S
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
-
D
Y
-
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
------
P
G
D
S
G
------
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
R
E
Q
I
R
-
E
M
N
P
N
-
Y
T
---
F
--------
P
Q
--
I
K
A
H
P
---
W
--------------------
T
--
K
-
V
F
-
R
-------------
P
R
T
---------------------
P
P
E
A
I
A
-------
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
35.55
31%
-34
- C1 -
-
4CFM
1
CDK2_HUMAN
C:
[6-292]
------------------------------------------------------------------------------------------------------------
M
-
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
L
T
G
-
E
-
V
-
V
A
L
K
K
I
R
LDT
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
--
I
V
K
L
-----
L
D
V
I
H
T
E
----------------
N
----
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
--
A
L
T
G
I
P
L
P
L
----
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
--
V
L
H
R
D
L
K
P
Q
N
L
L
I
---
N
--------
T
------------------------------------------------
E
-
G
---------
A
---------
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
PV
R
T
Y
H
E
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
C
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
------
P
G
D
S
E
------
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
------------------------------------------------------------------------------------------------
P
----
L
D
E
D
G
R
S
---------
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------