@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DYRK3_HUMAN: (2020-09-08 )
MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPRRLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS
Atome Classification :
(124 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220......-.-230-.-.....-------.240...---....250.......260.......270.......------280-----........290.......300.--.......310.......320....--.--..330.......340-------------.-----------------.----------------------..----.-----------------.---------.----350........360..--.-------....370.......380.-.-.....390.......400.......410.......420.......430-......-..440.......--..450........460.......470----.---...-----....480..-.--....490---------..-------.....500.......510.......520.......530.......540.......550.......560.......570.......580......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGGTARGPGRKDAGPPGAGL
P
P
Q
Q
R
RLGD
G
V
Y
D
T
F
M
M
I
DETKCPPCSNVLCNPSEPPPPRRLNM
T
T
E
QFTG
D
H
T
Q
H
FLDGG
E
M
K
V
E
Q
L
F
Q
E
FGNRKSNTIQSDGISDSEKCSPTVSQGKS
S
D
C
L
N
T
V
KSNSSSKA
P
K
V
V
PL
T
P
E
Q
A
L
K
Q
Y
K
H
H
L
T
A
Y
E
K
L
E
IINYP
E
I
Y
F
VGPNAKKRHGVIGGPNNGGYDDADG
A
Y
I
HVP
R
D
H
L
A
Y
R
Y
E
V
L
K
I
IGKGSF
G
Q
V
A
R
V
Y
D
-
H
-
K
L
R
-
Q
-
Y
V
A
L
K
-------
M
V
R
N
E
K
R
---
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
K
KQDKTGS
M
N
V
I
H
M
L
E
S
F
T------FR------N
H
V
C
M
A
F
E
L
L
S
I
D
L
Y
E
L
I
K
K-N--KFQG
F
S
V
Q
L
V
R
K
F
A
Q
S
I
L
Q
S
L
D
A
L
--H--KN
K
I
I
H
C
DLKPE
N
I
L
-------------
L
-----------------
K
----------------------HH----G-----------------R---------S----S-
T
K
V
I
DFG
S
S
C
F
E
Y
Q
--
K
-------
L
Y
T
Y
I
Q
S
R
FYRAPE
I
I
LG-S-RYSTP
I
D
I
W
S
F
G
C
I
L
A
E
L
LTGQPLFPGEDE
G
D
Q
L
A
C
M
M
E
L
LGMP
P
P
K
--
L
L
E
Q
S
K
-R
A
K
--
Y
F
INSKG--IP
R
-
Y
C
S
V
TTQAD
G
R
V
V
L
VGGRSRR-----G---KKR-----GPPGS
K
D
W
G
-
T
--
A
LKGC
D
D
---------
Y
L
-------
F
I
E
F
L
K
R
C
LHWDPSARL
T
P
A
Q
A
LRHPWISKSVPRPL
T
T
I
DKVSG
K
R
VV
N
P
A
S
A
F
Q
G
L
GSKLPP
V
V
G
I
A
N
K
L
K
A
N
L
MSETNGSI
P
L
C
S
V
L
P
K
LIS
507
HHSearch
96.92
100%
-97
- C1 -
-
5Y86
10
DYRK3_HUMAN
A:
[138-532]
-----------------------------------------------------------------------------------------------------------------------------------------
V
V
P
L
T
P
E
Q
A
L
K
Q
Y
K
H
H
L
T
A
Y
E
K
L
E
I
I
N
Y
P
E
I
Y
F
V
G
P
N
A
K
K
R
H
G
V
I
G
G
P
N
N
G
G
Y
D
D
A
D
G
A
Y
I
H
V
P
R
D
H
L
A
Y
R
Y
E
V
L
K
I
I
G
K
G
S
F
G
Q
V
A
R
V
Y
D
-
H
-
K
L
R
-
Q
-
Y
V
A
L
K
-------
M
V
R
N
E
K
R
---
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
K
K
Q
D
K
T
G
S
M
N
V
I
H
M
L
E
S
F
T
------
F
R
------
N
H
V
C
M
A
F
E
L
L
S
I
D
L
Y
E
L
I
K
K
-
N
--
K
F
Q
G
F
S
V
Q
L
V
R
K
F
A
Q
S
I
L
Q
S
L
D
A
L
--
H
--
K
N
K
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
K
----------------------
H
H
----
G
-----------------
R
---------
S
----
S
-
T
K
V
I
D
F
G
S
S
C
F
E
Y
Q
--
K
-------
L
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
I
I
L
G
-
S
-
R
Y
S
T
P
I
D
I
W
S
F
G
C
I
L
A
E
L
L
T
G
Q
P
L
F
P
G
E
D
E
G
D
Q
L
A
C
M
M
E
L
L
G
M
P
P
P
K
--
L
L
E
Q
S
K
-
R
A
K
--
Y
F
I
N
S
K
G
--
I
P
R
-
Y
C
S
V
T
T
Q
A
D
G
R
V
V
L
V
G
G
R
S
R
R
-----
G
---
K
K
R
-----
G
P
P
G
S
K
D
W
G
-
T
--
A
L
K
G
C
D
D
---------
Y
L
-------
F
I
E
F
L
K
R
C
L
H
W
D
P
S
A
R
L
T
P
A
Q
A
L
R
H
P
W
I
S
K
S
V
P
R
P
L
T
T
--------------------------------------------------------
1
PsiBlast_PDB
96.71
99%
-97
- C1 -
-
5Y86
10
DYRK3_HUMAN
A:
[138-532]
-----------------------------------------------------------------------------------------------------------------------------------------
V
V
P
L
T
P
E
Q
A
L
K
Q
Y
K
H
H
L
T
A
Y
E
K
L
E
I
I
N
Y
P
E
I
Y
F
V
G
P
N
A
K
K
R
H
G
V
I
G
G
P
N
N
G
G
Y
D
D
A
D
G
A
Y
I
H
V
P
R
D
H
L
A
Y
R
Y
E
V
L
K
I
I
G
K
G
S
F
G
Q
V
A
R
V
Y
D
-
H
-
K
L
R
-
Q
-
Y
V
A
L
K
-------
M
V
R
N
E
K
R
---
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
K
K
Q
D
K
T
G
S
M
N
V
I
H
M
L
E
S
F
T
------
F
R
------
N
H
V
C
M
A
F
E
L
L
S
I
D
L
Y
E
L
I
K
K
-
N
--
K
F
Q
G
F
S
V
Q
L
V
R
K
F
A
Q
S
I
L
Q
S
L
D
A
L
--
H
--
K
N
K
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
K
----------------------
H
H
----
G
-----------------
R
---------
S
----
S
-
T
K
V
I
D
F
G
S
S
C
F
E
Y
Q
--
K
-------
L
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
I
I
L
G
-
S
-
R
Y
S
T
P
I
D
I
W
S
F
G
C
I
L
A
E
L
L
T
G
Q
P
L
F
P
G
E
D
E
G
D
Q
L
A
C
M
M
E
L
L
G
M
P
P
P
K
--
L
L
E
Q
S
K
-
R
A
K
--
Y
F
I
N
S
K
G
--
I
P
R
-
Y
C
S
V
T
T
Q
A
D
G
R
V
V
L
V
G
G
R
S
R
R
-----
G
---
K
K
R
-----
G
P
P
G
S
K
D
W
G
-
T
--
A
L
K
G
C
D
D
---------
Y
L
-------
F
I
E
F
L
K
R
C
L
H
W
D
P
S
A
R
L
T
P
A
Q
A
L
R
H
P
W
I
S
K
S
V
P
R
P
L
T
T
--------------------------------------------------------
510
HHSearch
89.01
76%
-106
- C1 -
-
6HDP
1
DYRK2_HUMAN
A:
[31-419]
--------------------------------------------------------------------------------------------------------------------------------------------
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
V
A
L
K
-------
M
V
R
N
E
K
R
---
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
------
F
R
------
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
K
----------------------
Q
Q
----
G
-----------------
R
---------
S
----
G
-
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
--
R
-------
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
--
L
L
D
A
S
K
-
R
A
K
--
N
F
V
S
S
K
G
--
Y
P
R
-
Y
C
T
V
T
T
L
S
D
G
S
V
V
L
N
G
G
R
S
R
R
-----
G
---
K
L
R
-----
G
P
P
E
S
R
E
W
G
-
N
--
A
L
K
G
C
D
D
---------
P
L
-------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
L
P
K
P
-----------------------------------------------------------
8
PsiBlast_PDB
89.00
74%
-104
- C1 -
-
3K2L
-
DYRK2_HUMAN
A:
[27-420]
----------------------------------------------------------------------------------------------------------------------------------------
K
A
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
-
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
V
A
L
K
-------
M
V
R
N
E
K
R
---
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
------
F
R
------
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
K
----------------------
Q
Q
----
G
-----------------
R
---------
S
----
G
-
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
--
R
-------
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
--
L
L
D
A
S
K
-
R
A
K
--
N
F
V
S
S
K
G
--
Y
P
R
-
Y
C
T
V
T
T
L
S
D
G
S
V
V
L
N
G
G
R
S
R
R
-----
G
---
K
L
R
-----
G
P
P
E
S
R
E
W
G
-
N
--
A
L
K
G
C
D
D
---------
P
L
-------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
L
P
K
P
P
----------------------------------------------------------
5
PsiBlast_PDB
88.92
74%
-105
- C1 -
-
6HDP
1
DYRK2_HUMAN
A:
[27-419]
----------------------------------------------------------------------------------------------------------------------------------------
K
A
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
V
A
L
K
-------
M
V
R
N
E
K
R
---
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
------
F
R
------
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
K
----------------------
Q
Q
----
G
-----------------
R
---------
S
----
G
-
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
--
R
-------
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
--
L
L
D
A
S
K
-
R
A
K
--
N
F
V
S
S
K
G
--
Y
P
R
-
Y
C
T
V
T
T
L
S
D
G
S
V
V
L
N
G
G
R
S
R
R
-----
G
---
K
L
R
-----
G
P
P
E
S
R
E
W
G
-
N
--
A
L
K
G
C
D
D
---------
P
L
-------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
L
P
K
P
-----------------------------------------------------------
21
Blastp_CBE
88.57
75%
-101
- C1 -
-
5LXD
6
DYRK2_HUMAN
B:
[9-394]
-------------------------------------------------------------------------------------------------------------------------------------------
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
V
A
L
K
-------
M
V
R
N
E
K
R
---
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
------
F
R
------
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
K
----------------------
Q
Q
----
G
-----------------
R
---------
S
----
G
-
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
--
R
-------
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
--
L
L
D
A
S
K
-
R
A
K
--
N
F
V
S
S
K
G
--
Y
P
R
-
Y
C
T
V
T
T
L
S
D
G
S
V
V
L
N
G
G
R
S
R
R
-----
G
---
K
L
R
-----
G
P
P
E
S
R
E
W
G
-
N
--
A
L
K
G
C
D
D
---------
P
L
-------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
---------------------------------------------------------------
3
PsiBlast_PDB
87.80
74%
-102
- C1 -
-
5LXD
6
DYRK2_HUMAN
A:
[9-394]
-------------------------------------------------------------------------------------------------------------------------------------------
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
V
A
L
K
-------
M
V
R
N
E
K
R
---
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
------
F
R
------
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
K
----------------------
Q
Q
----
G
-----------------
R
---------
S
----
G
-
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
--
R
-------
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
--
L
L
D
A
S
K
-
R
A
K
--
N
F
V
S
S
K
G
--
Y
P
R
-
Y
C
T
V
T
T
L
S
D
G
S
V
V
L
N
G
G
R
S
R
R
-----
G
---
K
L
R
-----
G
P
P
E
S
R
E
W
G
-
N
--
A
L
K
G
C
D
D
---------
P
L
-------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
---------------------------------------------------------------
2
PsiBlast_PDB
87.50
74%
-103
- C1 -
-
5LXC
10
DYRK2_HUMAN
A:
[9-392]
-------------------------------------------------------------------------------------------------------------------------------------------
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
V
A
L
K
-------
M
V
R
N
E
K
R
---
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
------
F
R
------
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
K
----------------------
Q
Q
----
G
-----------------
R
---------
S
----
G
-
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
--
R
-------
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
--
L
L
D
A
S
K
-
R
A
K
--
N
F
V
S
S
K
G
--
Y
P
R
-
Y
C
T
V
T
T
L
S
D
G
S
V
V
L
N
G
G
R
S
R
R
-----
G
---
K
L
R
-----
G
P
P
E
S
R
E
W
G
-
N
--
A
L
K
G
C
D
D
---------
P
L
-------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------
508
HHSearch
87.44
75%
-102
- C1 -
-
5LXC
5
DYRK2_HUMAN
B:
[9-394]
-------------------------------------------------------------------------------------------------------------------------------------------
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
V
A
L
K
-------
M
V
R
N
E
K
R
---
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
------
F
R
------
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
K
----------------------
Q
Q
----
G
-----------------
R
---------
S
----
G
-
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
--
R
-------
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
--
L
L
D
A
S
K
-
R
A
K
--
N
F
V
S
S
K
G
--
Y
P
R
-
Y
C
T
V
T
T
L
S
D
G
S
V
V
L
N
G
G
R
S
R
R
-----
G
---
K
L
R
-----
G
P
P
E
S
R
E
W
G
-
N
--
A
L
K
G
C
D
D
---------
P
L
-------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
---------------------------------------------------------------
9
PsiBlast_PDB
87.38
75%
-106
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[27-413]
----------------------------------------------------------------------------------------------------------------------------------------
K
A
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
V
A
L
K
-------
M
V
R
N
E
K
R
---
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
------
F
R
------
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
K
----------------------
Q
Q
----
G
-----------------
R
---------
S
----
G
-
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
--
R
-------
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
--
L
L
D
A
S
K
-
R
A
K
--
N
F
V
S
S
K
G
--
Y
P
R
-
Y
C
T
V
T
T
L
S
D
--
V
V
L
N
G
G
R
S
R
R
-----
G
---
K
L
R
-----
G
P
P
E
S
R
E
W
G
-
N
--
A
L
K
G
C
D
D
---------
P
L
-------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------
22
Blastp_CBE
87.34
75%
-102
- C1 -
-
5LXC
5
DYRK2_HUMAN
B:
[9-394]
-------------------------------------------------------------------------------------------------------------------------------------------
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
V
A
L
K
-------
M
V
R
N
E
K
R
---
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
------
F
R
------
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
K
----------------------
Q
Q
----
G
-----------------
R
---------
S
----
G
-
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
--
R
-------
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
--
L
L
D
A
S
K
-
R
A
K
--
N
F
V
S
S
K
G
--
Y
P
R
-
Y
C
T
V
T
T
L
S
D
G
S
V
V
L
N
G
G
R
S
R
R
-----
G
---
K
L
R
-----
G
P
P
E
S
R
E
W
G
-
N
--
A
L
K
G
C
D
D
---------
P
L
-------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
---------------------------------------------------------------
7
PsiBlast_PDB
87.26
74%
-106
- C1 -
-
6HDR
2
DYRK2_HUMAN
A:
[27-413]
----------------------------------------------------------------------------------------------------------------------------------------
K
A
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
V
A
L
K
-------
M
V
R
N
E
K
R
---
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
------
F
R
------
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
K
----------------------
Q
Q
----
G
-----------------
R
---------
S
----
G
-
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
--
R
-------
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
--
L
L
D
A
S
K
-
R
A
K
--
N
F
V
S
S
K
G
--
Y
P
R
-
Y
C
T
V
T
T
L
S
D
--
V
V
L
N
G
G
R
S
R
R
-----
G
---
K
L
R
-----
G
P
P
E
S
R
E
W
G
-
N
--
A
L
K
G
C
D
D
---------
P
L
-------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------
509
HHSearch
87.13
76%
-107
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[31-413]
--------------------------------------------------------------------------------------------------------------------------------------------
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
V
A
L
K
-------
M
V
R
N
E
K
R
---
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
------
F
R
------
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
K
----------------------
Q
Q
----
G
-----------------
R
---------
S
----
G
-
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
--
R
-------
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
--
L
L
D
A
S
K
-
R
A
K
--
N
F
V
S
S
K
G
--
Y
P
R
-
Y
C
T
V
T
T
L
S
D
--
V
V
L
N
G
G
R
S
R
R
-----
G
---
K
L
R
-----
G
P
P
E
S
R
E
W
G
-
N
--
A
L
K
G
C
D
D
---------
P
L
-------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------
6
PsiBlast_PDB
86.94
74%
-105
- C1 -
-
3KVW
1
DYRK2_HUMAN
A:
[27-413]
----------------------------------------------------------------------------------------------------------------------------------------
K
A
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
V
A
L
K
-------
M
V
R
N
E
K
R
---
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
------
F
R
------
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
K
----------------------
Q
Q
----
G
-----------------
R
---------
S
----
G
-
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
--
R
-------
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
--
L
L
D
A
S
K
-
R
A
K
--
N
F
V
S
S
K
G
--
Y
P
R
-
Y
C
T
V
T
T
L
S
D
--
V
V
L
N
G
G
R
S
R
R
-----
G
---
K
L
R
-----
G
P
P
E
S
R
E
W
G
-
N
--
A
L
K
G
C
D
D
---------
P
L
-------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------
23
Blastp_CBE
86.84
75%
-102
- C1 -
-
5ZTN
1
DYRK2_HUMAN
B:
[27-413]
----------------------------------------------------------------------------------------------------------------------------------------
K
A
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
V
A
L
K
-------
M
V
R
N
E
K
R
---
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
------
F
R
------
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
K
----------------------
Q
Q
----
G
-----------------
R
---------
S
----
G
-
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
--
R
-------
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
--
L
L
D
A
S
K
-
R
A
K
--
N
F
V
S
S
K
G
--
Y
P
R
-
Y
C
T
V
T
-------
V
L
N
G
G
R
S
R
R
-----
G
---
K
L
R
-----
G
P
P
E
S
R
E
W
G
-
N
--
A
L
K
G
C
D
D
---------
P
L
-------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------
4
PsiBlast_PDB
86.54
74%
-104
- C1 -
-
5ZTN
1
DYRK2_HUMAN
A:
[27-413]
----------------------------------------------------------------------------------------------------------------------------------------
K
A
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
V
A
L
K
-------
M
V
R
N
E
K
R
---
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
------
F
R
------
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
K
----------------------
Q
Q
----
G
-----------------
R
---------
S
----
G
-
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
--
R
-------
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
--
L
L
D
A
S
K
-
R
A
K
--
N
F
V
S
S
K
G
--
Y
P
R
-
Y
C
T
V
T
-------
V
L
N
G
G
R
S
R
R
-----
G
---
K
L
R
-----
G
P
P
E
S
R
E
W
G
-
N
--
A
L
K
G
C
D
D
---------
P
L
-------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------
10
PsiBlast_PDB
80.89
76%
-118
- C1 -
-
6K0J
1
?
A:
[2-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
V
A
L
K
-------
M
V
R
N
N
K
R
---
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
------
F
R
------
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
A
K
P
E
N
I
L
-------------
L
-----------------
K
----------------------
Q
Q
----
G
-----------------
R
---------
S
----
G
-
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
--
R
-------
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
--
L
L
D
A
S
K
-
R
A
K
--
N
F
V
S
S
K
G
--
Y
P
R
-
Y
C
T
V
T
T
L
S
D
G
S
V
V
L
N
G
G
R
S
R
R
-----
G
---
K
L
R
-----
G
P
P
E
S
R
E
W
G
-
N
--
A
L
K
G
C
D
D
---------
P
L
-------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
A
A
---------------------------------------------------------------
511
HHSearch
80.52
78%
-118
- C1 -
-
6K0J
1
?
A:
[3-326]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
V
A
L
K
-------
M
V
R
N
N
K
R
---
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
------
F
R
------
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
A
K
P
E
N
I
L
-------------
L
-----------------
K
----------------------
Q
Q
----
G
-----------------
R
---------
S
----
G
-
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
--
R
-------
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
--
L
L
D
A
S
K
-
R
A
K
--
N
F
V
S
S
K
G
--
Y
P
R
-
Y
C
T
V
T
T
L
S
D
G
S
V
V
L
N
G
G
R
S
R
R
-----
G
---
K
L
R
-----
G
P
P
E
S
R
E
W
G
-
N
--
A
L
K
G
C
D
D
---------
P
L
-------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
A
----------------------------------------------------------------
528
Fugue
74.66
72%
-60
- C1 -
-
3K2L
-
DYRK2_HUMAN
A:
[11-420]
---------------
V
D
L
G
T
E
N
L
Y
F
M
-----------------------------------------------------------------------------------------------------------
G
K
V
K
A
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
-
G
M
T
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
-
Q
-
H
V
A
L
K
-------
M
V
R
N
E
K
R
---
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
------
F
R
------
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
-
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
K
----------------------
Q
Q
----
G
-----------------
R
---------
S
----
G
-
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
-----------
R
V
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
Q
-
K
--
L
L
D
A
S
K
-
R
A
K
--
N
F
V
S
-
K
G
--
Y
P
R
-
Y
C
T
V
T
T
L
S
D
G
S
V
V
L
N
G
G
R
S
R
R
-----
G
---
K
L
R
-----
G
P
P
E
S
R
E
W
G
-
N
--
A
L
K
G
C
D
D
---------
P
L
-------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
L
P
K
P
P
----------------------------------------------------------
520
HHSearch
63.66
42%
-62
- C1 -
-
6S1H
4
DYR1A_HUMAN
A:
[14-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
V
A
I
K
-------
I
I
K
N
K
K
A
---
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
------
F
R
------
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
AT
P
--
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
C
----------------------
N
P
----
K
-----------------
R
---------
S
----
A
-
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
--
R
-------
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
--
I
L
D
Q
A
P
-
K
A
R
--
K
F
F
E
K
L
P
DG
T
W
N
-
L
K
K
--------
Y
K
P
P
G
T
R
K
L
H
-----
N
ILG
V
E
T
-----
G
G
P
G
G
R
R
A
G
E
S
--
G
H
T
V
A
D
Y
---------
L
K
-------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
------------------------------------------------------------------
88
Blastp_CBE
61.36
43%
-65
- C1 -
-
6S1J
8
DYR1A_HUMAN
A:
[34-356]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
V
A
I
K
-------
I
I
K
N
K
K
A
---
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
------
F
R
------
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
C
----------------------
N
P
----
K
-----------------
R
---------
S
----
A
-
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
--
R
-------
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
--
I
L
D
Q
A
P
-
K
A
R
--
K
F
F
E
K
----
L
P
D
G
T
W
N
L
K
K
-------
Y
K
P
P
G
T
R
K
LHNIL
G
---
V
E
T
-----
G
G
P
G
G
R
R
A
G
-
E
--
S
G
H
T
V
A
D
---------
Y
L
K------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-----------------------------------------------------------------
95
Blastp_CBE
61.17
43%
-61
- C1 -
-
6S17
8
DYR1A_HUMAN
A:
[34-358]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
V
A
I
K
-------
I
I
K
N
K
K
A
---
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
------
F
R
------
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
C
----------------------
N
P
----
K
-----------------
R
---------
S
----
A
-
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
--
R
-------
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
--
I
L
D
Q
A
P
-
K
A
R
--
K
F
F
E
K
----
L
P
D
G
T
W
N
L
K
K
------
E
Y
K
P
P
G
T
R
K
LHNIL
G
---
V
E
T
-----
G
G
P
G
G
R
R
A
G
-
E
--
S
G
H
T
V
A
D
---------
Y
L
K------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
T
---------------------------------------------------------------
119
Blastp_CBE
60.52
43%
-58
- C1 -
-
6A1F
2
DYR1A_HUMAN
A:
[35-359]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
V
A
I
K
-------
I
I
K
N
K
K
A
---
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
------
F
R
------
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
C
----------------------
N
P
----
K
-----------------
R
---------
S
----
A
-
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
--
R
-------
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
--
I
L
D
Q
A
P
-
K
A
R
--
K
F
F
E
K
----
L
P
D
G
T
W
N
L
K
K
T
K
----
E
Y
K
P
P
G
T
R
K
LHNIL
G
---
V
E
T
-----
G
G
P
G
G
R
R
A
G
-
E
--
S
G
H
T
V
A
D
---------
Y
L
K------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
T
---------------------------------------------------------------
93
Blastp_CBE
60.44
43%
-65
- C1 -
-
6S1H
4
DYR1A_HUMAN
A:
[34-355]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
V
A
I
K
-------
I
I
K
N
K
K
A
---
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
------
F
R
------
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
C
----------------------
N
P
----
K
-----------------
R
---------
S
----
A
-
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
--
R
-------
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
--
I
L
D
Q
A
P
-
K
A
R
--
K
F
F
E
K
----
L
P
D
G
T
W
N
L
K
K
-------
Y
K
P
P
G
T
R
K
LHNIL
G
---
V
E
T
-----
G
G
P
G
G
R
R
A
G
-
E
--
S
G
H
T
V
A
D
---------
Y
L
K------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
------------------------------------------------------------------
98
Blastp_CBE
60.15
43%
-58
- C1 -
-
6S11
1
DYR1A_HUMAN
A:
[34-356]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
V
A
I
K
-------
I
I
K
N
K
K
A
---
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
------
F
R
------
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
C
----------------------
N
P
----
K
-----------------
R
---------
S
----
A
-
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
--
R
-------
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
--
I
L
D
Q
A
P
-
K
A
R
--
K
F
F
E
K
----
L
P
D
G
T
W
N
L
K
K
T
---
K
R
E
Y
K
P
P
G
T
R
K
LHNIL
G
---
V
E
T
-----
G
G
P
G
G
R
R
A
G
-
E
--
S
G
H
T
V
A
D
---------
Y
L
K------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-----------------------------------------------------------------
104
Blastp_CBE
60.04
43%
-60
- C1 -
-
4YLK
13
DYR1A_HUMAN
A:
[34-357]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
V
A
I
K
-------
I
I
K
N
K
K
A
---
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
------
F
R
------
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
C
----------------------
N
P
----
K
-----------------
R
---------
S
----
A
-
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
--
R
-------
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
--
I
L
D
Q
A
P
-
K
A
R
--
K
F
F
E
K
----
L
P
D
G
T
W
N
L
K
K
------
E
Y
K
P
P
G
T
R
K
LHNIL
G
---
V
E
T
-----
G
G
P
G
G
R
R
A
G
-
E
--
S
G
H
T
V
A
D
---------
Y
L
K------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------
132
Blastp_CBE
59.81
42%
-58
- C1 -
-
4AZE
1
DYR1A_HUMAN
B:
[55-378]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
V
A
I
K
-------
I
I
K
N
K
K
A
---
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
------
F
R
------
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
C
----------------------
N
P
----
K
-----------------
R
---------
S
----
A
-
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
--
R
-------
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
--
I
L
D
Q
A
P
-
K
A
R
--
K
F
F
E
K
----
L
P
D
G
T
W
N
L
K
K
T
K
D
G
K
R
E
Y
K
P
P
G
T
R
K
LHNIL
G
---
V
E
T
-----
G
G
P
G
G
R
R
A
G
-
E
--
S
G
H
T
V
A
D
---------
Y
L
K------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------
133
Blastp_CBE
59.65
42%
-58
- C1 -
-
4AZE
1
DYR1A_HUMAN
A:
[55-378]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
V
A
I
K
-------
I
I
K
N
K
K
A
---
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
------
F
R
------
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
C
----------------------
N
P
----
K
-----------------
R
---------
S
----
A
-
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
--
R
-------
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
--
I
L
D
Q
A
P
-
K
A
R
--
K
F
F
E
K
----
L
P
D
G
T
W
N
L
K
K
T
K
D
G
K
R
E
Y
K
P
P
G
T
R
K
LHNIL
G
---
V
E
T
-----
G
G
P
G
G
R
R
A
G
-
E
--
S
G
H
T
V
A
D
---------
Y
L
K------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------
124
Blastp_CBE
59.62
43%
-56
- C1 -
-
2WO6
1
DYR1A_HUMAN
B:
[55-377]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
V
A
I
K
-------
I
I
K
N
K
K
A
---
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
------
F
R
------
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
C
----------------------
N
P
----
K
-----------------
R
---------
S
----
A
-
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
--
R
-------
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
--
I
L
D
Q
A
P
-
K
A
R
--
K
F
F
E
K
----
L
P
D
G
T
W
N
L
K
-----
K
R
E
Y
K
P
P
G
T
R
K
LHNIL
G
---
V
E
T
-----
G
G
P
G
G
R
R
A
G
-
E
--
S
G
H
T
V
A
D
---------
Y
L
K------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-----------------------------------------------------------------
103
Blastp_CBE
59.47
43%
-61
- C1 -
-
4YLL
10
DYR1A_HUMAN
A:
[34-357]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
V
A
I
K
-------
I
I
K
N
K
K
A
---
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
-
K
Y
Y
I
V
H
L
K
R
H
F
M
------
F
R
------
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
C
----------------------
N
P
----
K
-----------------
R
---------
S
----
A
-
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
--
R
-------
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
--
I
L
D
Q
A
P
-
K
A
R
--
K
F
F
E
K
----
L
P
D
G
T
W
N
L
K
K
------
E
Y
K
P
P
G
T
R
K
LHNIL
G
---
V
E
T
-----
G
G
P
G
G
R
R
A
G
-
E
--
S
G
H
T
V
A
D
---------
Y
L
K------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------
131
Blastp_CBE
59.46
42%
-58
- C1 -
-
4AZE
1
DYR1A_HUMAN
C:
[55-378]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
V
A
I
K
-------
I
I
K
N
K
K
A
---
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
------
F
R
------
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
C
----------------------
N
P
----
K
-----------------
R
---------
S
----
A
-
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
--
R
-------
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
--
I
L
D
Q
A
P
-
K
A
R
--
K
F
F
E
K
----
L
P
D
G
T
W
N
L
K
K
T
K
D
G
K
R
E
Y
K
P
P
G
T
R
K
LHNIL
G
---
V
E
T
-----
G
G
P
G
G
R
R
A
G
-
E
--
S
G
H
T
V
A
D
---------
Y
L
K------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------
96
Blastp_CBE
59.31
43%
-63
- C1 -
-
6S14
1
DYR1A_HUMAN
A:
[34-357]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
V
A
I
K
-------
I
I
K
N
K
K
A
---
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
------
F
R
------
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
C
----------------------
N
P
----
K
-----------------
R
---------
S
----
A
-
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
--
R
-------
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
--
I
L
D
Q
A
P
-
K
A
R
--
K
F
F
E
K
----
L
P
D
G
T
W
N
L
K
K
-------
Y
K
P
P
G
T
R
K
LHNIL
G
---
V
E
T
-----
G
G
P
G
G
R
R
A
G
-
E
--
S
G
H
T
V
A
D
---------
Y
L
K------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------
94
Blastp_CBE
58.95
43%
-61
- C1 -
-
6S1B
2
DYR1A_HUMAN
A:
[34-357]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
V
A
I
K
-------
I
I
K
N
K
K
A
---
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
------
F
R
------
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
C
----------------------
N
P
----
K
-----------------
R
---------
S
----
A
-
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
--
R
-------
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
--
I
L
D
Q
A
P
-
K
A
R
--
K
F
F
E
K
------
D
G
T
W
N
L
K
K
-------
Y
K
P
P
G
T
R
K
LHNIL
G
---
V
E
T
-----
G
G
P
G
G
R
R
A
G
-
E
--
S
G
H
T
V
A
D
---------
Y
L
K------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------
118
Blastp_CBE
58.80
43%
-61
- C1 -
-
6A1G
1
DYR1A_HUMAN
A:
[35-357]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
V
A
I
K
-------
I
I
K
N
K
K
A
---
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
------
F
R
------
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
C
----------------------
N
-----------------------
R
---------
S
----
A
-
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
--
R
-------
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
--
I
L
D
Q
A
P
-
K
A
R
--
K
F
F
E
K
----
L
P
D
G
T
W
N
L
K
-------
E
Y
K
P
P
G
T
R
K
LHNIL
G
---
V
E
T
-----
G
G
P
G
G
R
R
A
G
-
E
--
S
G
H
T
V
A
D
---------
Y
L
K------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-----------------------------------------------------------------
117
Blastp_CBE
58.75
43%
-56
- C1 -
-
6A1G
1
DYR1A_HUMAN
B:
[35-357]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
V
A
I
K
-------
I
I
K
N
K
K
A
---
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
------
F
R
------
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
C
----------------------
N
P
----
K
-----------------
R
---------
S
----
A
-
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
--
R
-------
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
--
I
L
D
Q
A
P
-
K
A
R
--
K
F
F
E
K
----
L
P
D
G
T
W
N
L
K
--------
Y
K
P
P
G
T
R
K
LHNIL
G
---
V
E
T
-----
G
G
P
G
G
R
R
A
G
-
E
--
S
G
H
T
V
A
D
---------
Y
L
K------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-----------------------------------------------------------------
125
Blastp_CBE
58.33
43%
-56
- C1 -
-
2WO6
1
DYR1A_HUMAN
A:
[55-378]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
V
A
I
K
-------
I
I
K
N
K
K
A
---
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
------
F
R
------
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
C
----------------------
N
P
----
K
-----------------
R
---------
S
----
A
-
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
--
R
-------
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
--
I
L
D
Q
A
P
-
K
A
R
--
K
F
F
E
K
----
L
P
D
G
T
W
N
L
K
K
T
----
R
E
Y
K
P
P
G
T
R
K
LHNIL
G
---
V
E
T
-----
G
G
P
G
G
R
R
A
G
-
E
--
S
G
H
T
V
A
D
---------
Y
L
K------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------
184
Blastp_CBE
57.63
31%
-45
- C1 -
-
3NR9
1
CLK2_HUMAN
C:
[17-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
V
A
L
K
-------
I
I
K
N
V
E
K
---
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
------
Y
H
------
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
--
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
VNSDYELTYNLEK----
K
----------------------
R
D
----
E
-----------------
R
---------
S
VKST
A
-
V
R
V
V
D
F
G
S
A
T
F
D
H
E
--
H
-------
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
--
M
I
R
K
T
R
-
K
Q
K
--
Y
F
Y
R
G
------
R
-
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
-----
R
---
Y
-----------------
L
--
T
S
E
A
E
E
H
---------
H
Q
-------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
--------------------------------------------------------------
176
Blastp_CBE
57.54
31%
-46
- C1 -
-
5UNP
1
CLK2_HUMAN
B:
[18-356]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
V
A
L
K
-------
I
I
K
N
V
E
K
---
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
------
Y
H
------
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
--
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
VNSDYELTYNLEK----
K
----------------------
R
D
----
E
-----------------
R
---------
S
VKST
A
-
V
R
V
V
D
F
G
S
A
T
F
D
H
E
--
H
-------
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
--
M
I
R
K
T
R
-
K
Q
K
--
Y
F
Y
R
G
------
R
-
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
-----
R
---
Y
-----------------
L
--
T
S
E
A
E
E
H
---------
H
Q
-------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
--------------------------------------------------------------
177
Blastp_CBE
57.50
31%
-46
- C1 -
-
5UNP
1
CLK2_HUMAN
A:
[18-356]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
V
A
L
K
-------
I
I
K
N
V
E
K
---
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
------
Y
H
------
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
--
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
VNSDYELTYNLEK----
K
----------------------
R
D
----
E
-----------------
R
---------
S
VKST
A
-
V
R
V
V
D
F
G
S
A
T
F
D
H
E
--
H
-------
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
--
M
I
R
K
T
R
-
K
Q
K
--
Y
F
Y
R
G
------
R
-
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
-----
R
---
Y
-----------------
L
--
T
S
E
A
E
E
H
---------
H
Q
-------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
--------------------------------------------------------------
185
Blastp_CBE
57.33
31%
-44
- C1 -
-
3NR9
1
CLK2_HUMAN
B:
[17-354]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
V
A
L
K
-------
I
I
K
N
V
E
K
---
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
------
Y
H
------
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
--
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
VNSDYELTYNLEK----
K
----------------------
R
D
----
E
-----------------
R
---------
S
VKST
A
-
V
R
V
V
D
F
G
S
A
T
F
D
H
E
--
H
-------
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
--
M
I
R
K
T
R
-
K
Q
K
--
Y
F
Y
R
G
------
R
-
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
-----
R
---
Y
-----------------
L
--
T
S
E
A
E
E
H
---------
H
Q
-------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
---------------------------------------------------------------
171
Blastp_CBE
57.15
32%
-44
- C1 -
-
6FYP
1
CLK3_HUMAN
A:
[11-353]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
-
Q
V
A
L
K
-------
I
I
R
N
V
G
K
---
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
------
F
H
------
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
--
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
VNSEFETLYNEHKSCEE
K
----------------------
S
V
----
K
-----------------
N
---------
T
----
S
-
I
R
V
A
D
F
G
S
A
T
F
D
H
E
--
H
-------
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
--
M
I
H
R
T
R
-
K
Q
K
--
Y
F
Y
K
G
G
L
--
V
W
D
-----
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
---------------------
P
L
K
S
Y
M
L
Q
-
D
--
S
L
E
H
V
Q
-------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
-------------------------------------------------------------
173
Blastp_CBE
56.92
31%
-43
- C1 -
-
6FYK
1
CLK2_HUMAN
C:
[12-352]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
V
A
L
K
-------
I
I
K
N
V
E
K
---
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
------
Y
H
------
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
--
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
VNSDYELTYNLEK----
K
----------------------
R
D
----
E
-----------------
R
---------
S
VKST
A
-
V
R
V
V
D
F
G
S
A
T
F
D
H
E
--
H
-------
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
--
M
I
R
K
T
R
-
K
Q
K
--
Y
F
Y
R
G
------
R
-
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
-----
R
---
Y
-----------------
L
--
T
S
E
A
E
E
H
---------
H
Q
-------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
E
------------------------------------------------------------
175
Blastp_CBE
56.80
31%
-42
- C1 -
-
6FYK
1
CLK2_HUMAN
A:
[12-352]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
V
A
L
K
-------
I
I
K
N
V
E
K
---
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
------
Y
H
------
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
--
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
VNSDYELTYNLEK----
K
----------------------
R
D
----
E
-----------------
R
---------
S
VKST
A
-
V
R
V
V
D
F
G
S
A
T
F
D
H
E
--
H
-------
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
--
M
I
R
K
T
R
-
K
Q
K
--
Y
F
Y
R
G
------
R
-
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
-----
R
---
Y
-----------------
L
--
T
S
E
A
E
E
H
---------
H
Q
-------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
E
------------------------------------------------------------
174
Blastp_CBE
56.44
31%
-43
- C1 -
-
6FYK
1
CLK2_HUMAN
B:
[12-352]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
V
A
L
K
-------
I
I
K
N
V
E
K
---
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
------
Y
H
------
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
--
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
VNSDYELTYNLEK----
K
----------------------
R
D
----
E
-----------------
R
---------
S
VKST
A
-
V
R
V
V
D
F
G
S
A
T
F
D
H
E
--
H
-------
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
--
M
I
R
K
T
R
-
K
Q
K
--
Y
F
Y
R
G
------
R
-
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
-----
R
---
Y
-----------------
L
--
T
S
E
A
E
E
H
---------
H
Q
-------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
E
------------------------------------------------------------
190
Blastp_CBE
55.84
32%
-44
- C1 -
-
2WU6
7
CLK3_HUMAN
A:
[35-374]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
-
Q
V
A
L
K
-------
I
I
R
N
V
G
K
---
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
------
F
H
------
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
--
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
VNSEFETLYNEHKSCEE
K
----------------------
S
V
----
K
-----------------
N
---------
T
----
S
-
I
R
V
A
D
F
G
S
A
T
F
D
H
E
--
H
-------
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
--
M
I
H
R
T
R
-
K
Q
K
--
Y
F
Y
K
G
G
L
--
V
W
D
-----
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
---------------------
P
L
K
S
Y
M
L
Q
-
D
--
S
L
E
H
V
Q
-------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
-------------------------------------------------------------
170
Blastp_CBE
55.77
32%
-37
- C1 -
-
6FYR
1
CLK3_HUMAN
A:
[4-353]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
K
R
------
S
S
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
-
Q
V
A
L
K
-------
I
I
R
N
V
G
K
---
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
------
F
H
------
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
--
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
VNSEFETLYNEHKSCEE
K
----------------------
S
V
----
K
-----------------
N
---------
T
----
S
-
I
R
V
A
D
F
G
S
A
T
F
D
H
E
--
H
-------
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
--
M
I
H
R
T
R
-
K
Q
K
--
Y
F
Y
K
G
G
L
--
V
W
D
-----
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
---------------------
P
L
K
S
Y
M
L
Q
-
D
--
S
L
E
H
V
Q
-------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
-------------------------------------------------------------
189
Blastp_CBE
55.73
32%
-47
- C1 -
-
2WU7
1
CLK3_HUMAN
A:
[35-374]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
-
Q
V
A
L
K
-------
I
I
R
N
V
G
K
---
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
------
F
H
------
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
--
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
VNSEFETLYNEHKSCEE
K
----------------------
S
V
----
K
-----------------
N
---------
T
----
S
-
I
R
V
A
D
F
G
S
A
T
F
D
H
E
--
H
-------
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
--
M
I
H
R
T
R
-
K
Q
K
--
Y
F
Y
K
G
G
L
--
V
W
D
-----
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
---------------------
P
L
K
S
Y
M
L
Q
-
D
--
S
L
E
H
V
Q
-------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
-------------------------------------------------------------
188
Blastp_CBE
55.72
32%
-44
* C1 *
-
3RAW
1
CLK3_HUMAN
A:
[35-374]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
-
Q
V
A
L
K
-------
I
I
R
N
V
G
K
---
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
------
F
H
------
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
--
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
VNSEFETLYNEHKSCEE
K
----------------------
S
V
----
K
-----------------
N
---------
T
----
S
-
I
R
V
A
D
F
G
S
A
T
F
D
H
E
--
H
-------
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
--
M
I
H
R
T
R
-
K
Q
K
--
Y
F
Y
K
G
G
L
--
V
W
D
-----
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
---------------------
P
L
K
S
Y
M
L
Q
-
D
--
S
L
E
H
V
Q
-------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
-------------------------------------------------------------
179
Blastp_CBE
55.71
32%
-43
- C1 -
-
6RCT
7
CLK3_HUMAN
B:
[14-353]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
-
Q
V
A
L
K
-------
I
I
R
N
V
G
K
---
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
------
F
H
------
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
--
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
VNSEFETLYNEHKSCEE
K
----------------------
S
V
----
K
-----------------
N
---------
T
----
S
-
I
R
V
A
D
F
G
S
A
T
F
D
H
E
--
H
-------
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
--
M
I
H
R
T
R
-
K
Q
K
--
Y
F
Y
K
G
G
L
--
V
W
D
-----
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
---------------------
P
L
K
S
Y
M
L
Q
-
D
--
S
L
E
H
V
Q
-------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
-------------------------------------------------------------
172
Blastp_CBE
55.66
31%
-40
- C1 -
-
6FYL
1
CLK2_HUMAN
A:
[12-350]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
V
A
L
K
-------
I
I
K
N
V
E
K
---
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
------
Y
H
------
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
--
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
VNSDYELTYNLEK----
K
----------------------
R
D
----
E
-----------------
R
---------
S
VKST
A
-
V
R
V
V
D
F
G
S
A
T
F
D
H
E
--
H
-------
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
--
M
I
R
K
T
R
-
K
Q
K
--
Y
F
Y
R
G
------
R
-
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
-----
R
---
Y
-----------------
L
--
T
S
E
A
E
E
H
---------
H
Q
-------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
--------------------------------------------------------------
160
Blastp_CBE
55.48
35%
-42
- C1 -
-
5J1V
2
CLK1_HUMAN
A:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
187
Blastp_CBE
55.44
32%
-46
- C1 -
-
3RAW
1
CLK3_HUMAN
B:
[35-374]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
-
Q
V
A
L
K
-------
I
I
R
N
V
G
K
---
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
------
F
H
------
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
--
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
VNSEFETLYNEHKSCEE
K
----------------------
S
V
----
K
-----------------
N
---------
T
----
S
-
I
R
V
A
D
F
G
S
A
T
F
D
H
E
--
H
-------
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
--
M
I
H
R
T
R
-
K
Q
K
--
Y
F
Y
K
G
G
L
--
V
W
D
-----
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
---------------------
P
L
K
S
Y
M
L
Q
-
D
--
S
L
E
H
V
Q
-------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
-------------------------------------------------------------
159
Blastp_CBE
55.21
35%
-43
- C1 -
-
5J1V
1
CLK1_HUMAN
B:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
181
Blastp_CBE
55.18
32%
-40
- C1 -
-
6FT7
7
CLK3_HUMAN
B:
[14-353]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
-
Q
V
A
L
K
-------
I
I
R
N
V
G
K
---
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
------
F
H
------
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
--
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
VNSEFETLYNEHKSCEE
K
----------------------
S
V
----
K
-----------------
N
---------
T
----
S
-
I
R
V
A
D
F
G
S
A
T
F
D
H
E
--
H
-------
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
--
M
I
H
R
T
R
-
K
Q
K
--
Y
F
Y
K
G
G
L
--
V
W
D
-----
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
---------------------
P
L
K
S
Y
M
L
Q
-
D
--
S
L
E
H
V
Q
-------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
-------------------------------------------------------------
142
Blastp_CBE
55.05
35%
-48
- C1 -
-
6I5L
2
CLK1_HUMAN
B:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
182
Blastp_CBE
54.91
32%
-38
- C1 -
-
6FT7
7
CLK3_HUMAN
A:
[14-353]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
-
Q
V
A
L
K
-------
I
I
R
N
V
G
K
---
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
------
F
H
------
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
--
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
VNSEFETLYNEHKSCEE
K
----------------------
S
V
----
K
-----------------
N
---------
T
----
S
-
I
R
V
A
D
F
G
S
A
T
F
D
H
E
--
H
-------
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
--
M
I
H
R
T
R
-
K
Q
K
--
Y
F
Y
K
G
G
L
--
V
W
D
-----
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
---------------------
P
L
K
S
Y
M
L
Q
-
D
--
S
L
E
H
V
Q
-------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
-------------------------------------------------------------
191
Blastp_CBE
54.83
31%
-36
- C1 -
-
6KHE
1
CLK2_HUMAN
A:
[145-485]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
V
A
L
K
-------
I
I
K
N
V
E
K
---
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
------
Y
H
------
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
--
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
VNSDYELTYNLEK----
K
----------------------
R
D
----
E
-----------------
R
---------
S
VKST
A
-
V
R
V
V
D
F
G
S
A
T
F
D
H
E
--
H
-------
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
--
M
I
R
K
T
R
-
K
Q
K
--
Y
F
Y
--
R
G
--
R
L
D
-
W
D
E
N
T
S
A
--
G
R
Y
V
R
E
N
C
K
P
L
R
-----
R
---
Y
-----------------
L
--
T
S
E
A
E
E
H
---------
H
Q
-------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
E
------------------------------------------------------------
163
Blastp_CBE
54.77
35%
-43
- C1 -
-
5X8I
1
CLK1_HUMAN
A:
[9-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
-----------------------------------------------------------------
157
Blastp_CBE
54.77
35%
-42
- C1 -
-
5J1W
6
CLK1_HUMAN
A:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
183
Blastp_CBE
54.73
31%
-45
- C1 -
-
6FYI
1
CLK2_HUMAN
A:
[20-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
V
A
L
K
-------
I
I
K
N
V
E
K
---
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
------
Y
H
------
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
--
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
VNSDYELTYNLEK----
K
----------------------
R
D
----
E
-----------------
R
---------
S
VKST
A
-
V
R
V
V
D
F
G
S
A
T
F
D
H
E
--
H
-------
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
--
M
I
R
K
T
R
-
K
Q
K
--
Y
F
Y
R
G
------
R
-
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
-----
R
---
Y
-----------------
L
--
T
S
E
A
E
E
H
---------
H
Q
-------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
--------------------------------------------------------------
145
Blastp_CBE
54.43
35%
-43
- C1 -
-
6I5K
5
CLK1_HUMAN
B:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
97
Blastp_CBE
54.40
43%
-71
- C1 -
-
6S11
1
DYR1A_HUMAN
B:
[34-356]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
-
E
-
W
V
A
I
K
-------
I
I
K
N
K
K
A
---
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
------
F
R
------
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
-
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-------------
L
-----------------
C
----------------------
N
P
----
K
-----------------
R
---------
S
----
A
-
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
--
R
-------
I
---
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
--
I
L
D
Q
A
P
-
K
A
R
--
K
F
F
E
K
----
L
P
D
G
T
W
N
L
K
--------
Y
K
P
P
G
T
R
K
LHNIL
G
---
V
-
T
-----
G
G
P
G
G
R
----
E
--
S
G
H
T
V
A
D
---------
Y
L
K------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
-----------------------------------------------------------------
140
Blastp_CBE
54.35
35%
-42
- C1 -
-
6Q8K
2
CLK1_HUMAN
A:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
141
Blastp_CBE
54.33
35%
-46
- C1 -
-
6I5L
4
CLK1_HUMAN
C:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
153
Blastp_CBE
54.28
35%
-41
- C1 -
-
6FT9
4
CLK1_HUMAN
A:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
144
Blastp_CBE
54.16
35%
-43
- C1 -
-
6I5K
3
CLK1_HUMAN
C:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
143
Blastp_CBE
54.16
35%
-50
- C1 -
-
6I5L
3
CLK1_HUMAN
A:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
156
Blastp_CBE
54.15
35%
-42
- C1 -
-
5J1W
3
CLK1_HUMAN
B:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
162
Blastp_CBE
54.02
35%
-42
- C1 -
-
5X8I
1
CLK1_HUMAN
B:
[9-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
-----------------------------------------------------------------
152
Blastp_CBE
53.98
35%
-43
- C1 -
-
6FT9
2
CLK1_HUMAN
B:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
147
Blastp_CBE
53.92
35%
-44
- C1 -
-
6I5I
13
CLK1_HUMAN
A:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
---------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
154
Blastp_CBE
53.83
35%
-44
- C1 -
-
6FT8
7
CLK1_HUMAN
A:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
146
Blastp_CBE
53.71
35%
-45
- C1 -
-
6I5K
3
CLK1_HUMAN
A:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
515
HHSearch
53.69
32%
-40
- C1 -
-
6KHE
1
CLK2_HUMAN
A:
[154-485]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
-
R
G
G
-
A
-
R
V
A
L
K
-------
I
I
K
N
V
E
K
---
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
------
Y
H
------
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
--
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
-----------------
V
----------------------
N
S
----
D
YELTYNLEKKRDERSVK
S
---------
T
----
A
-
V
R
V
V
D
F
G
S
A
T
F
D
H
E
--
H
-------
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
--
M
I
R
K
T
R
-
K
Q
K
--
Y
F
Y
R
G
R
L
--
D
---
W
D
E
N
T
S
--
A
G
R
Y
V
R
E
N
C
K
P
L
R
-----------------------
R
Y
L
----
T
S
E
A
E
E
H
---------
H
Q
-------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
E
------------------------------------------------------------
151
Blastp_CBE
53.58
35%
-42
- C1 -
-
6FT9
2
CLK1_HUMAN
C:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
149
Blastp_CBE
53.53
35%
-36
- C1 -
-
6G33
1
CLK1_HUMAN
C:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
-
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
150
Blastp_CBE
53.51
35%
-40
- C1 -
-
6G33
1
CLK1_HUMAN
B:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
168
Blastp_CBE
53.47
35%
-41
- C1 -
-
6G33
1
CLK1_HUMAN
A:
[10-333]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
-----------------------------------------------------------------
186
Blastp_CBE
53.45
31%
-23
- C1 -
-
3NR9
1
CLK2_HUMAN
A:
[17-356]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
V
A
L
K
-------
I
I
K
N
V
E
K
---
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
N
L
C
V
Q
M
F
D
W
F
D
------
Y
H
------
G
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
-
N
--
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
--
D
N
K
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
VNSDYELT---------------------------------
D
----
E
-----------------
R
---------
S
VKST
A
-
V
R
V
V
D
F
G
S
A
T
F
D
H
E
--
H
-------
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
--
M
I
R
K
T
R
-
K
Q
K
--
Y
F
Y
R
G
------
R
-
L
D
W
D
E
N
T
S
A
G
R
Y
V
R
E
N
C
K
P
L
R
-----
R
---
Y
-----------------
L
--
T
S
E
A
E
E
H
---------
H
Q
-------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
-------------------------------------------------------------
314
Blastp_CBE
53.22
31%
-70
- C1 -
-
3LLT
1
?
A:
[37-359]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
V
I
R
K
M
G
D
G
T
F
G
R
V
L
L
C
Q
H
-
I
-
D
N
K
-
K
-
Y
Y
A
V
K
-------
V
V
R
N
I
K
K
---
Y
T
R
S
A
K
I
E
A
D
I
L
K
K
I
Q
N
D
D
I
N
N
N
N
I
V
K
Y
H
-
G
K
F
M
------
Y
Y
------
D
H
M
C
L
I
F
E
P
L
G
P
S
L
Y
E
I
I
T
R
-
N
--
N
Y
N
G
F
H
I
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
--
R
--
K
M
S
L
T
H
T
D
L
K
P
E
N
I
L
-------------
L
-----------------
D
DPYFEKSLITVRRVTDGKKIQI
Y
R
----
T
-----------------
K
---------
S
----
T
G
I
K
L
I
D
F
G
C
A
T
F
K
S
D
--
Y
-------
H
G
S
I
I
N
T
R
Q
Y
R
A
P
E
V
I
L
N
-
L
-
G
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
G
S
L
L
F
R
T
H
E
H
M
E
H
L
A
-
M
M
E
S
I
I
Q
P
I
P
K
NM
L
Y
E
A
T
K
T
N
G
S
--
K
Y
V
N
K
D
E
--
L
K
L
-
A
W
P
E
N
A
S
S
I
N
S
I
-------
K
H
-----
V
---
K
K
C
-----
L
P
-----------
L
Y
K
I
I
K
H
---------
E
L
-------
F
C
D
F
L
Y
S
I
L
Q
I
D
P
T
L
R
P
S
P
A
E
L
L
K
H
K
F
L
------------------------------------------------------------------
139
Blastp_CBE
53.16
35%
-43
- C1 -
-
6Q8P
1
CLK1_HUMAN
A:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
-
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
137
Blastp_CBE
52.83
35%
-32
- C1 -
-
6Q8P
1
CLK1_HUMAN
C:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNP-------------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
-
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
135
Blastp_CBE
52.74
35%
-30
- C1 -
-
6FYV
1
CLK4_HUMAN
A:
[10-333]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
R
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
G
M
D
G
M
-
H
V
A
V
K
-------
I
V
K
N
V
G
R
---
Y
R
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
S
T
D
P
N
S
V
F
R
C
V
Q
M
L
E
W
F
D
------
H
H
------
G
H
V
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
S
F
L
P
F
Q
I
D
H
I
R
Q
M
A
Y
Q
I
C
Q
S
I
N
F
L
--
H
--
H
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVKSDYV------
V
-----------------
K
----------------------
Y
N
-----------------------KRDERTLKN
T
----
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
Q
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
I
P
Q
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
N
--------------
Q
L
D
W
D
E
H
S
S
A
G
R
Y
V
R
----------
R
R
-----
C
K
P
-
L
K
E
F
M
-
L
--
C
H
D
E
E
H
E
---------
K
L
-------
F
-
D
L
V
R
R
M
L
E
Y
D
P
T
Q
R
I
T
L
D
E
A
L
Q
H
P
F
F
D
-----------------------------------------------------------------
161
Blastp_CBE
52.31
35%
-25
- C1 -
-
1Z57
1
CLK1_HUMAN
A:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYN-------------------------------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
513
HHSearch
52.30
36%
-30
- C1 -
-
6KHD
1
CLK1_HUMAN
B:
[151-480]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
-
A
G
G
-
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
-----------------
V
----------------------
Q
S
----
D
YTEAYNPKRDERTLI--
N
---------
P
----
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
R
L
--
D
W
D
-
E
H
S
----
S
A
G
R
Y
V
S
R
-----------
A
---
C
---------
K
P
L
K
E
F
--
M
--
L
S
Q
D
V
E
H
---------
E
R
-------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
---------------------------------------------------------------
165
Blastp_CBE
52.28
35%
-30
- C1 -
-
6KHD
1
CLK1_HUMAN
B:
[149-477]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNP-------------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
167
Blastp_CBE
52.24
34%
-71
- C1 -
-
6P5S
1
HIPK2_HUMAN
A:
[42-373]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
L
E
F
L
G
R
---
G
Q
V
V
K
C
W
K
-
R
-
G
T
N
-
E
-
I
V
A
I
K
-------
I
L
----------
R
Q
G
Q
I
E
V
S
I
L
A
R
L
S
T
E
-
S
A
D
D
Y
N
F
V
R
A
Y
E
C
F
Q
------
H
--------
H
T
C
L
V
F
E
M
L
E
Q
N
L
Y
D
F
L
K
Q
-
N
--
K
F
S
P
L
P
L
K
Y
I
R
P
V
L
Q
Q
V
A
T
A
L
M
K
L
--
K
--
S
L
G
L
I
H
A
D
L
K
P
E
N
I
M
-------------
L
-----------------
V
----------------------
D
P
----
S
-----------------
R
---------
Q
PY--
R
-
V
K
V
I
D
F
G
S
A
S
H
V
--------------
S
T
L
Q
S
R
Y
Y
R
A
P
E
I
I
L
G
-
L
-
P
F
C
E
A
I
D
M
W
S
L
G
C
V
I
A
E
L
F
L
G
W
P
L
Y
P
G
A
S
E
Y
D
Q
I
R
Y
I
S
Q
T
Q
G
L
P
A
E
Y
--
L
L
S
A
G
T
-
K
T
T
--
R
F
F
N
R
D
T
--
D
P
Y
-
P
L
W
R
L
K
T
P
D
D
H
E
A
E
T
G
I
K
S
K
E
-----
A
---
R
K
Y
IFNCL
D
D
M
A
Q
V
N
M
T
-
T
--
D
L
E
G
S
D
M
---------
L
V
EKADRRE
F
I
D
L
L
K
K
M
L
T
I
D
A
D
K
R
I
T
P
I
E
T
L
N
H
P
F
V
T
M
T
---------------------------------------------------------------
138
Blastp_CBE
52.06
35%
-34
- C1 -
-
6Q8P
1
CLK1_HUMAN
B:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNP------------------------------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
--
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
192
Blastp_CBE
51.58
32%
-31
- C1 -
-
6KHF
1
CLK3_HUMAN
A:
[142-477]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
L
V
C
R
I
G
D
W
L
Q
E
D
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
-
S
-
Q
V
A
L
K
-------
I
I
R
N
V
G
K
---
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
------
F
H
------
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
--
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
VNSEF-----------------------------------
S
V
----
K
-----------------
N
---------
T
----
S
-
I
R
V
A
D
F
G
S
A
T
F
D
H
E
--
H
-------
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
--
M
I
H
R
T
R
-
K
Q
K
--
Y
F
Y
K
G
G
L
--
V
-----
W
D
E
N
S
S
D
G
R
Y
V
K
E
N
C
K
---------------------
P
L
K
S
Y
M
L
Q
-
D
--
S
L
E
H
V
Q
-------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
-------------------------------------------------------------
512
HHSearch
51.55
36%
-33
- C1 -
-
6KHD
1
CLK1_HUMAN
A:
[150-480]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
-
A
G
G
-
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
-----------------
V
----------------------
Q
S
----
D
YTEERTLI---------
N
---------
P
----
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
--
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
R
L
----
D
-
W
D
E
H
S
--
S
A
G
R
Y
V
S
R
-----------
A
---
C
K
--------
P
-
L
K
E
F
M
----
L
S
Q
D
V
E
H
---------
E
R
-------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
---------------------------------------------------------------
169
Blastp_CBE
51.39
35%
-21
- C1 -
-
2VAG
1
CLK1_HUMAN
A:
[10-333]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYN--------------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
-----------------------------------------------------------------
158
Blastp_CBE
51.33
35%
-52
- C1 -
-
5J1V
2
CLK1_HUMAN
C:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
---
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
---------------------------------------------------
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
514
HHSearch
51.19
35%
-24
- C1 -
-
6KHF
1
CLK3_HUMAN
A:
[146-478]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
R
I
G
D
W
L
Q
E
D
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
-
A
R
G
-
K
S
Q
V
A
L
K
-------
I
I
R
N
V
G
K
---
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
D
W
F
N
------
F
H
------
G
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
-
N
--
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
-------------
F
-----------------
V
----------------------
N
S
EFSV
K
-----------------
N
---------
T
----
S
-
I
R
V
A
D
F
G
S
A
T
F
D
H
E
--
H
-------
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
-
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
--
M
I
H
R
T
R
-
K
Q
K
--
Y
F
Y
K
G
G
L
--
V
W
D
-
E
N
S
----
S
D
G
R
Y
V
K
E
--------------------------
N
C
K
P
L
K
-
S
YM
L
Q
D
S
L
E
H
---------
V
Q
-------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
------------------------------------------------------------
155
Blastp_CBE
50.84
35%
-45
- C1 -
-
5J1W
5
CLK1_HUMAN
C:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYNPK
I
-----------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
------------------------------------------------------
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
134
Blastp_CBE
50.81
36%
-18
- C1 -
-
6FYO
1
CLK1_HUMAN
A:
[10-333]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYN--------------------
K
----------------------
R
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
-----
S
R
R
-----
C
---
K
P
L
----------
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
-----------------------------------------------------------------
148
Blastp_CBE
50.67
35%
-25
- C1 -
-
6I5H
6
CLK1_HUMAN
A:
[10-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYT-----------------------------------------------------------------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
166
Blastp_CBE
50.42
35%
-29
- C1 -
-
6KHD
1
CLK1_HUMAN
A:
[149-477]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTE----------------------------------------------------
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
--
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
164
Blastp_CBE
49.60
35%
-13
- C1 -
-
6KHD
1
CLK1_HUMAN
C:
[150-477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
V
A
V
K
-------
I
V
K
N
V
D
R
---
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
------
H
H
------
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
-
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
FVQSDYTEAYN--------------------------------------------
D
----
E
-----------------
R
---------
T
LINP
D
-
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
-------
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
--
M
I
Q
K
T
R
-
K
R
K
--
Y
F
H
H
D
------
R
-
L
D
W
D
E
H
S
S
A
G
R
Y
V
------------------
S
R
-----
A
C
K
P
L
K
E
F
M
-
L
--
S
Q
D
V
E
H
E
---------
R
L
-------
F
-
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
------------------------------------------------------------------
527
HHSearch
46.59
33%
-27
- C1 -
-
4ZSG
6
MK07_HUMAN
A:
[5-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
-
R
-
L
T
G
-
Q
-
Q
V
A
I
K
-------
K
I
P
N
A
F
D
VVT
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
------
H
D
N
I
I
A
I
K
D
I
L
R
PTVPYG
E
F
------
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
-
S
----
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
--
H
--
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
-------------
V
-----------------
N
----------------------
E
N
----
C
--------------------------------
E
-
L
K
I
G
D
F
G
M
A
R
G
L
C
T
--
S
PAEHQYF
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
-
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
--
V
I
Q
A
V
G
-
A
E
R
VR
A
Y
I
Q
S
----
L
P
---------------------------------
P
R
-----
Q
---
P
V
P
W
E
-
T
--
V
Y
-
P
G
A
D
---------
R
Q
-------
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
--------------------------------------------------------------
206
Blastp_CBE
46.08
31%
-12
- C1 -
-
6PK6
1
A:
[14-351]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
T
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
-
N
A
R
A
N
-
Q
-
E
V
A
V
K
-------
I
I
R
N
N
E
L
---
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
R
H
F
Y
------
H
K
------
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
--
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
--
K
--
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
-------------
V
----------------------------------------
N
E
----
S
-----------------
K
---------
T
----
I
-
L
K
L
C
D
F
G
S
A
S
H
V
A
D
--
N
-------
D
I
T
P
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
-
K
-
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
--
M
I
R
K
G
V
-
F
K
D
--
Q
H
F
D
Q
N
L
--
N
F
M
-
Y
I
E
V
D
K
--------
V
T
E
R
E
K
V
-----
T
---
V
M
S
-----
T
I
N
P
T
K
D
L
L
-
A
--
D
L
I
G
C
Q
R
LPEDQRKKV
H
Q
-------
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
----------------------------------------------------------------
193
Blastp_CBE
45.84
31%
-6
- C1 -
-
4IJP
1
B:
[13-350]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
T
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
-
N
A
R
A
N
-
Q
-
E
V
A
V
K
-------
I
I
R
N
N
E
L
---
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
R
H
F
Y
------
H
K
------
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
--
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
--
K
--
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
-------------
V
----------------------------------------
N
E
----
S
-----------------
K
---------
T
----
I
-
L
K
L
C
D
F
G
S
A
S
H
V
A
D
--
N
-------
D
I
T
P
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
-
K
-
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
--
M
I
R
K
G
V
-
F
K
D
--
Q
H
F
D
Q
N
L
--
N
F
M
-
Y
I
E
V
D
K
------------
E
K
V
-----
T
---
V
M
S
-----
T
I
N
P
T
K
D
L
L
-
A
--
D
L
I
G
C
Q
R
LPEDQRKKV
H
Q
-------
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
K
---------------------------------------------------------------
524
HHSearch
45.22
32%
-21
- C1 -
-
4NM3
5
GSK3B_HUMAN
A:
[55-343]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
V
A
I
K
-------
K
V
L
Q
D
K
------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
------
H
C
N
I
V
R
L
R
Y
F
F
Y
------
S
S
KKDE--
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
-
Y
SR
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
--
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
-------------
L
-----------------
D
----------------------
P
D
----
T
---------------------------
A
----
V
-
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
GE
P
-------
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
-
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
--
Q
I
R
E
M
N
-
P
N
Y
--
T
E
F
K
-----
F
P
Q
-
I
----------------------------------------
K
A
H
P
W
T
-
K
--
V
F
R
P
R
T
P
---------
P
E
-------
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
---------------------------------------------------------------
267
Blastp_CBE
45.01
31%
-25
- C1 -
-
4EHV
3
MK14_HUMAN
A:
[23-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
-
T
-
K
T
G
-
L
-
R
V
A
V
K
KLSRPFQ
S
I
I
H
A
K
R
---
T
Y
R
----
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
------
E
F
------
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
--
K
L
T
D
D
H
V
Q
F
L
---
I
Y
Q
I
L
R
G
L
K
Y
I
--
H
--
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
-------------
V
-----------------
N
----------------------
E
D
--------------------------------
C
----
E
-
L
K
I
L
D
F
G
L
--------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
--
L
L
K
K
----------
I
S
S
E
S
--
A
R
N
-
Y
I
Q
S
L
T
Q
M
---------------------------------
P
K
M
N
F
A
-
N
--
V
F
I
G
A
N
P
----------
L
-------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----------------------------------------------------------------
194
Blastp_CBE
44.36
31%
-5
- C1 -
-
4IJP
1
PRP4B_HUMAN
A:
[15-350]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
-
N
A
R
A
N
-
Q
-
E
V
A
V
K
-------
I
I
R
N
N
E
L
---
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
R
H
F
Y
------
H
K
------
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
--
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
--
K
--
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
-------------
V
----------------------------------------
N
E
----
S
-----------------
K
---------
T
----
I
-
L
K
L
C
D
F
G
S
A
S
H
V
A
D
--
N
-------
D
I
T
P
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
-
K
-
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
--
M
I
R
K
G
V
-
F
K
D
--
Q
H
F
D
Q
N
L
--
N
F
M
-
Y
I
E
V
D
K
-----------
R
E
K
V
-----
T
---
V
M
S
-----
T
I
N
P
T
K
D
L
L
-
A
--
D
L
I
G
--
R
LPEDQRKKV
H
Q
-------
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
K
---------------------------------------------------------------
281
Blastp_CBE
44.28
31%
-25
- C1 -
-
3QUE
3
MK14_HUMAN
A:
[23-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
-
T
-
K
T
G
-
L
-
R
V
A
V
K
KLSRPFQ
S
I
I
H
A
K
R
---
T
Y
R
----
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
------
E
F
------
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
--
K
L
T
D
D
H
V
Q
F
L
---
I
Y
Q
I
L
R
G
L
K
Y
I
--
H
--
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
-------------
V
-----------------
N
----------------------
E
D
--------------------------------
C
----
E
-
L
K
I
L
D
F
G
L
A
R
H
T
D
---------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
--
L
L
K
K
----------
I
S
S
E
S
--
A
R
N
-
Y
I
Q
S
L
T
Q
M
---------------------------------
P
K
M
N
F
A
-
N
--
V
F
I
G
A
N
P
----------
L
-------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----------------------------------------------------------------
525
HHSearch
44.09
31%
-12
- C1 -
-
1J1B
1
GSK3B_HUMAN
A:
[54-344]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
-
D
S
G
-
E
-
L
V
A
I
K
-------
K
V
L
Q
D
K
------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
------
H
C
N
I
V
R
L
R
Y
F
F
Y
------
S
S
GEKKDE
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
-
Y
SR
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
--
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
-------------
L
-----------------
D
----------------------
P
D
----
T
---------------------------
A
----
V
-
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
GE
P
-------
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
-
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
--
Q
I
R
E
M
N
-
P
N
Y
--
T
E
F
K
-----
F
P
Q
-----------------------------------------
I
K
A
H
P
W
T
-
K
--
V
F
R
P
R
T
P
---------
P
E
-------
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
--------------------------------------------------------------
237
Blastp_CBE
43.57
31%
-19
- C1 -
-
3GCP
3
MK14_HUMAN
A:
[23-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
-
T
-
K
T
G
-
L
-
R
V
A
V
K
KLSRPFQ
S
I
I
H
A
K
R
---
T
Y
R
----
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
------
E
F
------
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
S
-
Q
--
K
L
T
D
D
H
V
Q
F
L
---
I
Y
Q
I
L
R
G
L
K
Y
I
--
H
--
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
-------------
V
-----------------
N
----------------------
E
D
--------------------------------
S
----
E
-
L
K
I
L
D
F
G
L
C
---------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
--
L
L
K
K
----------
I
S
S
E
S
--
A
R
N
-
Y
I
Q
S
L
T
Q
M
---------------------------------
P
K
M
N
F
A
-
N
--
V
F
I
G
A
N
P
----------
L
-------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----------------------------------------------------------------
195
Blastp_CBE
43.55
31%
-1
- C1 -
-
4IIR
1
B:
[15-350]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
---
S
N
V
V
R
A
R
D
-
N
A
R
A
N
-
Q
-
E
V
A
V
K
-------
I
I
R
N
N
E
L
---
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
R
H
F
Y
------
H
K
------
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
--
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
--
K
--
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
-------------
V
----------------------------------------
N
E
----
S
-----------------
K
---------
T
----
I
-
L
K
L
C
D
F
G
S
A
S
H
V
A
D
--
N
-------
D
I
T
P
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
-
K
-
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
--
M
I
R
K
G
V
-
F
K
D
--
Q
H
F
D
Q
N
L
--
N
F
M
-
Y
I
E
V
D
K
-----------
R
E
K
V
-----
T
---
V
M
S
-----
T
I
N
P
T
K
D
L
L
-
A
--
D
L
I
G
--
R
LPEDQRKKV
H
Q
-------
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
K
---------------------------------------------------------------
196
Blastp_CBE
43.16
31%
1
- C1 -
-
4IIR
1
PRP4B_HUMAN
A:
[13-350]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
T
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
--
S
N
V
V
R
A
R
D
-
N
A
R
A
N
-
Q
-
E
V
A
V
K
-------
I
I
R
N
N
E
L
---
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
R
H
F
Y
------
H
K
------
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
--
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
--
K
--
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
-------------
V
----------------------------------------
N
E
----
S
-----------------
K
---------
T
----
I
-
L
K
L
C
D
F
G
S
A
S
H
V
A
D
--
N
-------
D
I
T
P
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
-
K
-
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
--
M
I
R
K
G
V
-
F
K
D
--
Q
H
F
D
Q
N
L
--
N
F
M
-
Y
I
E
--------------
R
E
K
V
-----
T
---
V
M
S
-----
T
I
N
P
T
K
D
L
L
-
A
--
D
L
I
G
---PEDQRKKV-
H
Q
-------
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
K
---------------------------------------------------------------
266
Blastp_CBE
43.14
31%
-24
- C1 -
-
4L8M
3
MK14_HUMAN
A:
[23-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
-
T
-
K
T
G
-
L
-
R
V
A
V
K
KLSRPFQ
S
I
I
H
A
K
R
---
T
Y
R
----
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
------
E
F
------
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
-----
K
L
T
D
D
H
V
Q
F
L
---
I
Y
Q
I
L
R
G
L
K
Y
I
--
H
--
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
-------------
V
-----------------
N
----------------------
E
D
--------------------------------
C
----
E
-
L
K
I
L
D
F
G
L
A
R
H
T
----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
--
L
L
K
K
----------
I
S
S
E
S
--
A
R
N
-
Y
I
Q
S
L
T
Q
M
---------------------------------
P
K
M
N
F
A
-
N
--
V
F
I
G
A
N
P
----------
L
-------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----------------------------------------------------------------
317
Blastp_CBE
43.12
31%
-21
- C1 -
-
6HWV
4
MK14_HUMAN
A:
[25-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
-
T
-
K
T
G
-
L
-
R
V
A
V
K
KLSRPFQ
S
I
I
H
A
K
R
---
T
Y
R
----
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
------
E
F
------
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
--
K
L
T
D
D
H
V
Q
F
L
---
I
Y
Q
I
L
R
G
L
K
Y
I
--
H
--
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
-------------
V
-----------------
N
----------------------
E
D
--------------------------------
C
----
E
-
L
K
I
L
D
F
G
L
---------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
--
L
L
K
K
----------
I
S
S
E
S
--
A
R
N
-
Y
I
Q
S
L
T
Q
M
---------------------------------
P
K
M
N
F
A
-
N
--
V
F
I
G
A
N
P
----------
L
-------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----------------------------------------------------------------
282
Blastp_CBE
43.12
31%
-19
- C1 -
-
3QUD
3
MK14_HUMAN
A:
[23-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
-
T
-
K
T
G
-
L
-
R
V
A
V
K
KLSRPFQ
S
I
I
H
A
K
R
---
T
Y
R
----
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
------
E
F
------
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
--
K
L
T
D
D
H
V
Q
F
L
---
I
Y
Q
I
L
R
G
L
K
Y
I
--
H
--
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
-------------
V
-----------------
N
----------------------
E
D
--------------------------------
C
----
E
-
L
K
I
L
D
F
G
L
A
R
H
T
D
---------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
--
L
L
K
K
----------
I
S
S
E
S
--
A
R
N
-
Y
I
Q
S
L
T
Q
M
---------------------------------
P
K
M
N
F
A
-
N
--
V
F
I
G
A
N
P
----------
L
-------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----------------------------------------------------------------
323
Blastp_CBE
42.83
31%
-22
- C1 -
-
3ZS5
6
MK14_HUMAN
A:
[25-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
-
T
-
K
T
G
-
L
-
R
V
A
V
K
KLSRPFQ
S
I
I
H
A
K
R
---
T
Y
R
----
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
------
E
F
------
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
--
K
L
T
D
D
H
V
Q
F
L
---
I
Y
Q
I
L
R
G
L
K
Y
I
--
H
--
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
-------------
V
-----------------
N
----------------------
E
D
--------------------------------
C
----
E
-
L
K
I
L
D
F
G
L
---------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
--
L
L
K
K
----------
I
S
S
E
S
--
A
R
N
-
Y
I
Q
S
L
T
Q
M
---------------------------------
P
K
M
N
F
A
-
N
--
V
F
I
G
A
N
P
----------
L
-------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----------------------------------------------------------------
197
Blastp_CBE
42.68
31%
2
- C1 -
-
4IFC
1
B:
[15-350]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
-
V
F
S
N
V
V
R
A
R
D
-
N
A
R
A
N
-
Q
-
E
V
A
V
K
-------
I
I
R
N
N
E
L
---
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
R
H
F
Y
------
H
K
------
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
--
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
--
K
--
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
-------------
V
----------------------------------------
N
E
----
S
-----------------
K
---------
T
----
I
-
L
K
L
C
D
F
G
S
A
S
H
V
A
D
--
N
-------
D
I
T
P
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
-
K
-
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
--
M
I
R
K
G
V
-
F
K
D
--
Q
H
F
D
Q
N
L
--
N
F
M
-
Y
I
E
V
D
K
-----------
R
E
K
V
-----
T
---
V
M
S
-----
T
I
N
P
T
K
D
L
L
-
A
--
D
L
I
G
--
R
LPEDQRKKV
H
Q
-------
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
K
---------------------------------------------------------------
319
Blastp_CBE
42.62
31%
-24
- C1 -
-
6HWT
4
MK14_HUMAN
A:
[25-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
S
-
A
Y
G
S
V
C
A
A
F
D
-
T
-
K
T
G
-
L
-
R
V
A
V
K
KLSRPFQ
S
I
I
H
A
K
R
---
T
Y
R
----
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
------
E
F
------
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
--
K
L
T
D
D
H
V
Q
F
L
---
I
Y
Q
I
L
R
G
L
K
Y
I
--
H
--
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
-------------
V
-----------------
N
----------------------
E
D
--------------------------------
C
----
E
-
L
K
I
L
D
F
G
L
A
R
--------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
--
L
L
K
K
----------
I
S
S
E
S
--
A
R
N
-
Y
I
Q
S
L
T
Q
M
---------------------------------
P
K
M
N
F
A
-
N
--
V
F
I
G
A
N
P
----------
L
-------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----------------------------------------------------------------
379
Blastp_CBE
42.58
31%
-33
- C1 -
-
5ML5
4
MK14_HUMAN
A:
[23-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
D
-
T
-
K
T
G
-
L
-
R
V
A
V
K
KLSRPFQ
S
I
I
H
A
K
R
---
T
Y
R
----
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
------
E
F
------
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
--
K
L
T
D
D
H
V
Q
F
L
---
I
Y
Q
I
L
R
G
L
K
Y
I
--
H
--
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
-------------
V
-----------------
N
----------------------
E
D
--------------------------------
C
----
E
-
L
K
I
L
D
F
G
-----------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
--
L
L
K
K
----------
I
S
S
E
S
--
A
R
N
-
Y
I
Q
S
L
T
---------------------------------------
F
A
-
N
--
V
F
I
G
A
N
P
----------
L
-------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----------------------------------------------------------------
268
Blastp_CBE
42.55
31%
-31
- C1 -
-
4EH9
2
MK14_HUMAN
A:
[23-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
D
-
T
-
K
T
G
-
L
-
R
V
A
V
K
KLSRPFQ
S
I
I
H
A
K
R
---
T
Y
R
----
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
------
E
F
------
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
------
K
L
T
D
D
H
V
Q
F
L
---
I
Y
Q
I
L
R
G
L
K
Y
I
--
H
--
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
-------------
V
-----------------
N
----------------------
E
D
--------------------------------
C
----
E
-
L
K
I
L
D
F
G
L
--------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
--
L
L
K
K
----------
I
S
S
E
S
--
A
R
N
-
Y
I
Q
S
L
T
Q
M
---------------------------------
P
K
M
N
F
A
-
N
--
V
F
I
G
A
N
P
----------
L
-------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----------------------------------------------------------------
318
Blastp_CBE
42.50
31%
-33
- C1 -
-
6HWU
4
MK14_HUMAN
A:
[25-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
-
T
-
K
T
G
-
L
-
R
V
A
V
K
KLSRPFQ
S
I
I
H
A
K
R
---
T
Y
R
----
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
------
E
F
------
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
--------
L
T
D
D
H
V
Q
F
L
---
I
Y
Q
I
L
R
G
L
K
Y
I
--
H
--
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
-------------
V
-----------------
N
----------------------
E
D
--------------------------------
C
----
E
-
L
K
I
L
D
F
G
L
--------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
--
L
L
K
K
----------
I
S
S
E
S
--
A
R
N
-
Y
I
Q
S
L
T
Q
M
---------------------------------
P
K
M
N
F
A
-
N
--
V
F
I
G
A
N
P
----------
L
-------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----------------------------------------------------------------
230
Blastp_CBE
42.31
31%
-19
- C1 -
-
3IW6
4
MK14_HUMAN
A:
[23-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
D
-
T
-
K
T
G
-
L
-
R
V
A
V
K
KLSRPFQ
S
I
I
H
A
K
R
---
T
Y
R
----
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
------
E
F
------
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
S
-
Q
--
K
L
T
D
D
H
V
Q
F
L
---
I
Y
Q
I
L
R
G
L
K
Y
I
--
H
--
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
-------------
V
-----------------
N
----------------------
E
D
--------------------------------
S
----
E
-
L
K
I
L
D
F
G
L
--------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
--
L
L
K
K
----------
I
S
S
E
S
--
A
R
N
-
Y
I
Q
S
L
T
Q
M
---------------------------------
P
K
M
N
F
A
-
N
--
V
F
I
G
A
N
P
----------
L
-------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----------------------------------------------------------------
198
Blastp_CBE
42.28
31%
2
- C1 -
-
4IFC
1
PRP4B_HUMAN
A:
[13-350]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
T
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
-
N
A
R
A
N
-
Q
-
E
V
A
V
K
-------
I
I
R
N
N
E
L
---
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
R
H
F
Y
------
H
K
------
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
--
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
--
K
--
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
-------------
V
----------------------------------------
N
E
----
S
-----------------
K
---------
T
----
I
-
L
K
L
C
D
F
G
S
A
S
H
V
A
D
--
N
-------
D
I
T
P
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
-
K
-
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
--
M
I
R
K
G
V
-
F
K
D
--
Q
H
F
D
Q
N
L
--
N
F
M
-
Y
I
E
--------------
R
E
K
V
-----
T
---
V
M
S
-----
T
I
N
P
T
K
D
L
L
-
A
--
D
L
I
G
---PEDQRKKV-
H
Q
-------
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
K
---------------------------------------------------------------
269
Blastp_CBE
42.22
31%
-17
- C1 -
-
4EH8
3
MK14_HUMAN
A:
[23-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
D
-
T
-
K
T
G
-
L
-
R
V
A
V
K
KLSRPFQ
S
I
I
H
A
K
R
---
T
Y
R
----
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
------
E
F
------
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
--
K
L
T
D
D
H
V
Q
F
L
---
I
Y
Q
I
L
R
G
L
K
Y
I
--
H
--
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
-------------
V
-----------------
N
----------------------
E
D
--------------------------------
C
----
E
-
L
K
I
L
D
F
----------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
--
L
L
K
K
----------
I
S
S
E
S
--
A
R
N
-
Y
I
Q
S
L
T
Q
M
---------------------------------
P
K
M
N
F
A
-
N
--
V
F
I
G
A
N
P
----------
L
-------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----------------------------------------------------------------
232
Blastp_CBE
41.64
31%
-11
- C1 -
-
3HV3
3
MK14_HUMAN
A:
[23-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
D
-
T
-
K
T
G
-
L
-
R
V
A
V
K
KLSRPFQ
S
I
I
H
A
K
R
---
T
Y
R
----
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
------
E
F
------
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
S
-
Q
--
K
L
T
D
D
H
V
Q
F
L
---
I
Y
Q
I
L
R
G
L
K
Y
I
--
H
--
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
-------------
V
-----------------
N
----------------------
E
D
--------------------------------
S
----
E
-
L
K
I
L
D
F
G
---------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
--
L
L
K
K
----------
I
S
S
E
S
--
A
R
N
-
Y
I
Q
S
L
T
Q
M
---------------------------------
P
K
M
N
F
A
-
N
--
V
F
I
G
A
N
P
----------
L
-------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----------------------------------------------------------------
229
Blastp_CBE
40.32
31%
-13
- C1 -
-
3IW7
4
MK14_HUMAN
A:
[23-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
D
-
T
-
K
T
G
-
L
-
R
V
A
V
K
KLSRPFQ
S
I
I
H
A
K
R
---
T
Y
R
----
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
------
E
F
------
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
S
-
Q
--
K
L
T
D
D
H
V
Q
F
L
---
I
Y
Q
I
L
R
G
L
K
Y
I
--
H
--
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
-------------
V
-----------------
N
----------------------
E
D
--------------------------------
S
----
E
-
L
K
I
L
D
F
G
L
---------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
--
L
L
K
K
----------
I
S
S
E
S
--
A
R
N
-
Y
I
Q
S
L
T
Q
M
---------------------------------
P
K
M
N
F
A
-
N
--
V
F
I
G
A
N
P
----------
L
-------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----------------------------------------------------------------
262
Blastp_CBE
39.38
31%
-26
- C1 -
-
2FST
3
MK14_HUMAN
X:
[30-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
-
T
-
K
T
G
-
L
-
R
V
A
V
K
KLSRPFQ
S
I
I
H
A
K
R
---
T
Y
R
----
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
L
E
------
E
F
------
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
------
Q
--
K
L
T
D
D
H
V
Q
F
L
---
I
Y
Q
I
L
R
G
L
K
Y
I
--
H
--
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
-------------
V
-----------------
N
----------------------
E
D
--------------------------------
C
----
E
-
L
K
I
L
D
------------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
-
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
--
L
L
K
K
----------
I
S
S
E
S
--
A
R
N
-
Y
I
Q
S
L
T
Q
M
---------------------------------
P
K
M
N
F
A
-
N
--
V
F
I
G
A
N
P
----------
L
-------
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
----------------------------------------------------------------