@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DYRK4_HUMAN: (2020-09-08 )
MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLPQLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKNTNVLPPIV
Atome Classification :
(112 SA)
.........10........20........30....-....40........50........60........70........80........90........100.......110.......120.-.-.-...-.-130.-------......140.......150.......160.-------......170..-------...----..180.......190.......200........210.......220-...-.--....230.....--------.-----------------------.240--..-----------------..-----------------.....250------.......260.-......270......-.280.......290.......300..-....-----.310.......320.......330...-..-.--.340----.-.--.-------------....---------------.---------------350------------.----.-.-.--.--------.--...---360--------------.------------------.-..----------.-..370------------.------------------.......380.......390.......400.......410-.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
P
A
S
ELKASEIPFHPSIKTQDPKAEEKSPKK
Q
K
V
T
-
L
T
A
A
E
A
L
K
L
F
K
N
QLSPY
E
Q
S
E
I
L
G
Y
A
E
L
W
FLGLEAKKLDTA
P
E
K
FSKTSFDDEHG
F
Y
L
K
V
L
H
D
H
I
A
Y
R
Y
E
V
L
E
T
IGKG
S
F
G
Q
V
A
K
C
L
D-H-K-NN
E
-
L
-
V
A
L
K
-------
I
I
R
N
K
K
R
F
H
Q
Q
A
L
M
E
L
K
I
L
E
A
L
R
KKDKDNT-------
Y
N
V
V
H
M
K
D
F
F
Y
-------
F
RN----
H
F
C
I
T
F
E
LLG
I
N
L
Y
E
L
M
KNNNFQ-G
F
S
L
S
I
V
R
R
F
T
L
S
V
L
K
C
L
Q
M
L
--
S
V
E
-
K
--
I
IHCDLKPE
N
I
V
--------
L
-----------------------
Y
Q----KG-----------------Q
A
-----------------
S
V
K
V
I
DFG------S
S
C
Y
E
H
Q
K
V
Y
T
-
Y
I
Q
S
R
FYRSP
E
V
I
LG-HPY
D
V
A
I
D
M
WSL
G
C
I
T
A
E
L
YTGYPLF-PGE
N
-----
E
V
E
Q
L
A
C
I
M
E
V
LGLPP
A
G
F
I
Q
T
A
S
R
R
Q
-TF-F--DSK-----G-F--P-------------KNIT---------------N---------------N--------------R----G-K-K--R--------Y--PDS---K
D
L
--------------
T
------------------
M
-
V
L
----------K-TYD
T
-------------
S
------------------
F
L
D
F
L
R
R
CLVWEPSLRM
T
P
D
Q
A
L
K
H
A
W
I
HQSRNLKPQPR
P
-
Q
T
L
RKSNSFFPSETR
K
D
K
V
QGCHHSSR
K
A
D
E
I
T
K
E
T
T
EKTKDSPT
K
H
VQHSG
D
Q
Q
D
C
L
Q
HGADTVQL
P
Q
L
VDAPKKSEAAVG
A
E
V
S
MTSPGQSKNFSLKNTNVLPPIV
21
Blastp_CBE
95.22
54%
-94
- C1 -
-
5LXD
6
DYRK2_HUMAN
B:
[9-394]
----------------------------------
P
-
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
-
V
H
Q
-
H
-
V
A
L
K
-------
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
-------
M
N
V
I
H
M
L
E
N
F
T
-------
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
-
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
N
-
R
--
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
K
Q
----
Q
G
-----------------
R
S
-----------------
G
I
K
V
I
D
F
G
------
S
S
C
Y
E
H
Q
R
V
Y
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
-
P
G
E
D
-----
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
-
N
F
-
V
--
S
S
K
-----
G
-
Y
--
P
-------------
R
Y
C
T
VTTLSDGSVVLNGGR
S
---------------
R
--------------
R
----
G
-
K
-
L
--
R
--------
G
P-
P
E
S
---
R
E
W
--------------
G
------------------
N
-
A
L
----------
K
-
G
C
D
D
-------------
P
L-----------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
--
R
R
--------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
94.42
53%
-92
- C1 -
-
6HDP
1
DYRK2_HUMAN
A:
[25-419]
-----------------------------
K
V
K
A
T
P
-
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
-
V
H
Q
-
H
-
V
A
L
K
-------
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
-------
M
N
V
I
H
M
L
E
N
F
T
-------
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
-
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
N
-
R
--
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
K
Q
----
Q
G
-----------------
R
S
-----------------
G
I
K
V
I
D
F
G
------
S
S
C
Y
E
H
Q
R
V
Y
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
-
P
G
E
D
-----
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
-
N
F
-
V
--
S
S
K
-----
G
-
Y
--
P
-------------
R
Y
C
T
VTTLSDGSVVLNGGR
S
---------------
R
--------------
R
----
G
-
K
-
L
--
R
--------
G
P-
P
E
S
---
R
E
W
--------------
G
------------------
N
-
A
L
----------
K
-
G
C
D
D
-------------
P
L-----------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
--
R
R
L
---
P
K
P
-------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
94.30
53%
-94
- C1 -
-
5LXD
6
DYRK2_HUMAN
A:
[9-394]
----------------------------------
P
-
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
-
V
H
Q
-
H
-
V
A
L
K
-------
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
-------
M
N
V
I
H
M
L
E
N
F
T
-------
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
-
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
N
-
R
--
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
K
Q
----
Q
G
-----------------
R
S
-----------------
G
I
K
V
I
D
F
G
------
S
S
C
Y
E
H
Q
R
V
Y
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
-
P
G
E
D
-----
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
-
N
F
-
V
--
S
S
K
-----
G
-
Y
--
P
-------------
R
Y
C
T
VTTLSDGSVVLNGGR
S
---------------
R
--------------
R
----
G
-
K
-
L
--
R
--------
G
P-
P
E
S
---
R
E
W
--------------
G
------------------
N
-
A
L
----------
K
-
G
C
D
D
-------------
P
L-----------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
--
R
R
--------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
93.91
52%
-90
- C1 -
-
3K2L
-
DYRK2_HUMAN
A:
[25-420]
-----------------------------
K
V
K
A
T
P
-
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
-
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
-
V
H
Q
-
H
-
V
A
L
K
-------
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
-------
M
N
V
I
H
M
L
E
N
F
T
-------
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
-
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
N
-
R
--
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
K
Q
----
Q
G
-----------------
R
S
-----------------
G
I
K
V
I
D
F
G
------
S
S
C
Y
E
H
Q
R
V
Y
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
-
P
G
E
D
-----
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
-
N
F
-
V
--
S
S
K
-----
G
-
Y
--
P
-------------
R
Y
C
T
VTTLSDGSVVLNGGR
S
---------------
R
--------------
R
----
G
-
K
-
L
--
R
--------
G
P-
P
E
S
---
R
E
W
--------------
G
------------------
N
-
A
L
----------
K
-
G
C
D
D
-------------
P
L-----------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
--
R
R
L
---
P
K
P
-
P
-----------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
93.81
51%
-82
- C1 -
-
5Y86
10
DYRK3_HUMAN
A:
[138-531]
------------------------------
V
--
V
P
-
L
T
P
E
Q
A
L
K
Q
Y
K
H
H
L
T
A
Y
E
K
L
E
I
I
N
Y
P
E
I
Y
F
V
G
P
N
A
K
K
R
H
G
V
I
G
G
P
N
N
G
G
Y
D
D
A
D
G
A
Y
I
H
V
P
R
D
H
L
A
Y
R
Y
E
V
L
K
I
I
G
K
G
S
F
G
Q
V
A
R
V
Y
D
-
H
-
K
-
L
R
Q
-
Y
-
V
A
L
K
-------
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
K
K
Q
D
K
T
G
S
-------
M
N
V
I
H
M
L
E
S
F
T
-------
F
R
N
----
H
V
C
M
A
F
E
L
L
S
I
D
L
Y
E
L
I
K
K
N
K
F
Q
-
G
F
S
V
Q
L
V
R
K
F
A
Q
S
I
L
Q
S
L
D
A
L
--
H
K
N
-
K
--
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
K
H
----
H
G
-----------------
R
S
-----------------
S
T
K
V
I
D
F
G
------
S
S
C
F
E
Y
Q
K
L
Y
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
I
I
L
G
-
S
R
Y
S
T
P
I
D
I
W
S
F
G
C
I
L
A
E
L
L
T
G
Q
P
L
F
-
P
G
E
D
-----
E
G
D
Q
L
A
C
M
M
E
L
L
G
M
P
P
P
K
L
L
E
Q
S
K
R
A
K
-
Y
F
-
I
--
N
S
K
-----
G
-
I
--
P
-------------
R
Y
C
S
VTTQADGRVVLVGGR
S
---------------
R
--------------
R
----
G
-
K
-
K
--
R
--------
G
P-
P
G
S
---
K
D
W
--------------
G
------------------
T
-
A
L
----------
K
-
G
C
D
D
-------------
Y
L-----------------
F
I
E
F
L
K
R
C
L
H
W
D
P
S
A
R
L
T
P
A
Q
A
L
R
H
P
W
I
S
K
S
-----
V
P
R
P
-
L
T
----------------------------------------------------------------------------------------------------------
231
HHSearch
93.52
55%
-96
- C1 -
-
6HDP
1
DYRK2_HUMAN
A:
[30-416]
----------------------------------
P
-
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
-
V
H
Q
-
H
-
V
A
L
K
-------
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
-------
M
N
V
I
H
M
L
E
N
F
T
-------
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
-
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
N
-
R
--
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
K
Q
----
Q
G
-----------------
R
S
-----------------
G
I
K
V
I
D
F
G
------
S
S
C
Y
E
H
Q
R
V
Y
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
-
P
G
E
D
-----
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
-
N
F
-
V
--
S
S
K
-----
G
-
Y
--
P
-------------
R
Y
C
T
---------------
V
TTLSDGSVVLNG---
G
--------------
R
S---
R
-
R
-
G
--
K
--------
L
--
R
G
P
PES
R
E
W
G-------------
N
------------------
A
-
L
K
----------
G
-
C
D
D
P
-------------
L
------------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
L
---------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
92.90
53%
-97
- C1 -
-
5LXC
10
DYRK2_HUMAN
A:
[9-392]
----------------------------------
P
-
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
-
V
H
Q
-
H
-
V
A
L
K
-------
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
-------
M
N
V
I
H
M
L
E
N
F
T
-------
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
-
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
N
-
R
--
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
K
Q
----
Q
G
-----------------
R
S
-----------------
G
I
K
V
I
D
F
G
------
S
S
C
Y
E
H
Q
R
V
Y
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
-
P
G
E
D
-----
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
-
N
F
-
V
--
S
S
K
-----
G
-
Y
--
P
-------------
R
Y
C
T
VTTLSDGSVVLNGGR
S
---------------
R
--------------
R
----
G
-
K
-
L
--
R
--------
G
P-
P
E
S
---
R
E
W
--------------
G
------------------
N
-
A
L
----------
K
-
G
C
D
D
-------------
P
L-----------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
------------------------------------------------------------------------------------------------------------------------
233
HHSearch
92.66
54%
-88
- C1 -
-
5Y86
10
DYRK3_HUMAN
A:
[138-525]
--------------------------------
V
V
P
-
L
T
P
E
Q
A
L
K
Q
Y
K
H
H
L
T
A
Y
E
K
L
E
I
I
N
Y
P
E
I
Y
F
V
G
P
N
A
K
K
R
H
G
V
I
G
G
P
N
N
G
G
Y
D
D
A
D
G
A
Y
I
H
V
P
R
D
H
L
A
Y
R
Y
E
V
L
K
I
I
G
K
G
S
F
G
Q
V
A
R
V
Y
D
-
H
-
K
-
L
R
Q
-
Y
-
V
A
L
K
-------
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
K
K
Q
D
K
T
G
S
-------
M
N
V
I
H
M
L
E
S
F
T
-------
F
R
N
----
H
V
C
M
A
F
E
L
L
S
I
D
L
Y
E
L
I
K
K
N
K
F
Q
-
G
F
S
V
Q
L
V
R
K
F
A
Q
S
I
L
Q
S
L
D
A
L
--
H
K
N
-
K
--
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
K
H
----
H
G
-----------------
R
S
-----------------
S
T
K
V
I
D
F
G
------
S
S
C
F
E
Y
Q
K
L
Y
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
I
I
L
G
-
S
R
Y
S
T
P
I
D
I
W
S
F
G
C
I
L
A
E
L
L
T
G
Q
P
L
F
-
P
G
E
D
-----
E
G
D
Q
L
A
C
M
M
E
L
L
G
M
P
P
P
K
L
L
E
Q
S
K
R
A
K
-
Y
F
-
I
--
N
S
K
-----
G
-
I
--
P
-------------
R
Y
C
S
---------------
V
---------------
T
TQADGRVVLVGGRS
R
----
R
-
G
-
K
KR
G
--------
P
--
P
G
S
---
K
D
W
--------------
G
------------------
T
A
L
K
----------
G
-
C
D
D
Y
-------------
L
------------------
F
I
E
F
L
K
R
C
L
H
W
D
P
S
A
R
L
T
P
A
Q
A
L
R
H
P
W
I
S
K
S
----------------------------------------------------------------------------------------------------------------------
230
HHSearch
92.48
56%
-95
- C1 -
-
5LXC
5
DYRK2_HUMAN
B:
[9-394]
----------------------------------
P
-
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
-
V
H
Q
-
H
-
V
A
L
K
-------
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
-------
M
N
V
I
H
M
L
E
N
F
T
-------
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
-
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
N
-
R
--
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
K
Q
----
Q
G
-----------------
R
S
-----------------
G
I
K
V
I
D
F
G
------
S
S
C
Y
E
H
Q
R
V
Y
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
-
P
G
E
D
-----
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
-
N
F
-
V
--
S
S
K
-----
G
-
Y
--
P
-------------
R
Y
C
T
---------------
V
TTLSDGSVVLNGGRS
R
--------------
R
----
G
-
K
L
R
--
G
--------
P
--
P
E
S
---
R
E
W
G-------------
N
------------------
A
-
L
K
----------
G
-
C
D
D
P
-------------
L
------------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
----------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
92.44
54%
-93
- C1 -
-
5LXC
5
DYRK2_HUMAN
B:
[9-394]
----------------------------------
P
-
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
-
V
H
Q
-
H
-
V
A
L
K
-------
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
-------
M
N
V
I
H
M
L
E
N
F
T
-------
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
-
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
N
-
R
--
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
K
Q
----
Q
G
-----------------
R
S
-----------------
G
I
K
V
I
D
F
G
------
S
S
C
Y
E
H
Q
R
V
Y
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
-
P
G
E
D
-----
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
-
N
F
-
V
--
S
S
K
-----
G
-
Y
--
P
-------------
R
Y
C
T
VTTLSDGSVVLNGGR
S
---------------
R
--------------
R
----
G
-
K
-
L
--
R
--------
G
P-
P
E
S
---
R
E
W
--------------
G
------------------
N
-
A
L
----------
K
-
G
C
D
D
-------------
P
L-----------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
--
R
R
--------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
91.97
53%
-96
- C1 -
-
6HDR
2
DYRK2_HUMAN
A:
[25-413]
-----------------------------
K
V
K
A
T
P
-
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
-
V
H
Q
-
H
-
V
A
L
K
-------
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
-------
M
N
V
I
H
M
L
E
N
F
T
-------
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
-
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
N
-
R
--
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
K
Q
----
Q
G
-----------------
R
S
-----------------
G
I
K
V
I
D
F
G
------
S
S
C
Y
E
H
Q
R
V
Y
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
-
P
G
E
D
-----
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
-
N
F
-
V
--
S
S
K
-----
G
-
Y
--
P
-------------
R
Y
C
T
VTTLSDVVLNGGR--
S
---------------
R
--------------
R
----
G
-
K
-
L
--
R
--------
G
P-
P
E
S
---
R
E
W
--------------
G
------------------
N
-
A
L
----------
K
-
G
C
D
D
-------------
P
L-----------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
------------------------------------------------------------------------------------------------------------------------
232
HHSearch
91.93
56%
-100
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[29-413]
---------------------------------
T
P
-
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
-
V
H
Q
-
H
-
V
A
L
K
-------
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
-------
M
N
V
I
H
M
L
E
N
F
T
-------
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
-
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
N
-
R
--
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
K
Q
----
Q
G
-----------------
R
S
-----------------
G
I
K
V
I
D
F
G
------
S
S
C
Y
E
H
Q
R
V
Y
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
-
P
G
E
D
-----
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
-
N
F
-
V
--
S
S
K
-----
G
-
Y
--
P
-------------
R
Y
C
T
---------------
V
TTLSDVVLNG-----
G
--------------
R
----
S
R
R
-
G
--
K
--------
L
--
R
G
P
PES
R
E
W
G-------------
N
------------------
A
-
L
K
----------
G
-
C
D
D
P
-------------
L
------------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
91.67
53%
-97
- C1 -
-
5ZTN
1
DYRK2_HUMAN
A:
[25-413]
-----------------------------
K
V
K
A
T
P
-
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
-
V
H
Q
-
H
-
V
A
L
K
-------
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
-------
M
N
V
I
H
M
L
E
N
F
T
-------
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
-
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
N
-
R
--
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
K
Q
----
Q
G
-----------------
R
S
-----------------
G
I
K
V
I
D
F
G
------
S
S
C
Y
E
H
Q
R
V
Y
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
-
P
G
E
D
-----
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
-
N
F
-
V
--
S
S
K
-----
G
-
Y
--
P
-------------
R
Y
C
T
VTVLNGGR-------
S
---------------
R
--------------
R
----
G
-
K
-
L
--
R
--------
G
P-
P
E
S
---
R
E
W
--------------
G
------------------
N
-
A
L
----------
K
-
G
C
D
D
-------------
P
L-----------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
91.56
53%
-98
- C1 -
-
3KVW
1
DYRK2_HUMAN
A:
[25-413]
-----------------------------
K
V
K
A
T
P
-
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
-
V
H
Q
-
H
-
V
A
L
K
-------
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
-------
M
N
V
I
H
M
L
E
N
F
T
-------
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
-
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
N
-
R
--
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
K
Q
----
Q
G
-----------------
R
S
-----------------
G
I
K
V
I
D
F
G
------
S
S
C
Y
E
H
Q
R
V
Y
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
-
P
G
E
D
-----
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
-
N
F
-
V
--
S
S
K
-----
G
-
Y
--
P
-------------
R
Y
C
T
VTTLSDVVLNGGR--
S
---------------
R
--------------
R
----
G
-
K
-
L
--
R
--------
G
P-
P
E
S
---
R
E
W
--------------
G
------------------
N
-
A
L
----------
K
-
G
C
D
D
-------------
P
L-----------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
86.90
54%
-83
- C1 -
-
5ZTN
1
DYRK2_HUMAN
B:
[25-413]
-----------------------------
K
V
K
A
T
P
-
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
-
V
H
Q
-
H
-
V
A
L
K
-------
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
-------
M
N
V
I
H
M
L
E
N
F
T
-------
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
-
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
N
-
R
--
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
K
Q
----
Q
G
-----------------
R
S
-----------------
G
I
K
V
I
D
F
G
------
S
S
C
Y
E
H
Q
R
V
Y
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
-
P
G
E
D
-----
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
-
A
S
K
R
A
-
K
N
-
F
--
V
S
K
-----
G
-
Y
--
P
-------------
R
Y
C
T
VTTLNGGR-------
S
---------------
R
--------------
R
----
G
-
K
-
L
--
R
--------
G
P-
P
E
S
---
R
E
W
--------------
G
------------------
N
-
A
L
----------
K
-
G
C
D
D
-------------
P
L-----------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
--
R
---------------------------------------------------------------------------------------------------------------------
237
HHSearch
86.03
61%
-109
* C1 *
-
6K0J
1
?
A:
[3-326]
------------------------------------------------------------------------------------------------
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
-
V
H
Q
-
H
-
V
A
L
K
-------
M
V
R
N
N
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
-------
M
N
V
I
H
M
L
E
N
F
T
-------
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
-
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
N
-
R
--
I
I
H
C
D
A
K
P
E
N
I
L
--------
L
-----------------------
K
Q
----
Q
G
-----------------
R
S
-----------------
G
I
K
V
I
D
F
G
------
S
S
C
Y
E
H
Q
R
V
Y
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
-
P
G
E
D
-----
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
-
N
F
-
V
--
S
S
K
-----
G
-
Y
--
P
-------------
R
Y
C
T
---------------
V
TTLSDGSVVLNGGRS
R
--------------
R
----
G
-
K
-
L
R-
G
--------
P
--
P
E
S
---
R
E
W
G-------------
N
------------------
A
-
L
K
----------
G
-
C
D
D
P
-------------
L
------------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
A
-----------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
85.35
57%
-103
- C1 -
-
6K0J
1
?
A:
[1-327]
----------------------------------------------------------------------------------------------
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
-
V
H
Q
-
H
-
V
A
L
K
-------
M
V
R
N
N
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
-------
M
N
V
I
H
M
L
E
N
F
T
-------
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
-
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
N
-
R
--
I
I
H
C
D
A
K
P
E
N
I
L
--------
L
-----------------------
K
Q
----
Q
G
-----------------
R
S
-----------------
G
I
K
V
I
D
F
G
------
S
S
C
Y
E
H
Q
R
V
Y
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
-
P
G
E
D
-----
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
-
N
F
-
V
--
S
S
K
-----
G
-
Y
--
P
-------------
R
Y
C
T
VTTLSDGSVVLNGGR
S
---------------
R
--------------
R
----
G
-
K
-
L
--
R
--------
G
P-
P
E
S
---
R
E
W
--------------
G
------------------
N
-
A
L
----------
K
-
G
C
D
D
-------------
P
L-----------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
A
A
----------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
82.94
54%
-28
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[21-413]
--------------------------
Q
S
M
G
K
V
K
A
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
-
V
H
Q
-
H
-
V
A
L
K
-------
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
-------
M
N
V
I
H
M
L
E
N
F
T
-------
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
-
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
N
-
R
--
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
K
Q
----
Q
G
-----------------
R
S
-----------------
G
I
K
V
I
D
F
G
------
S
S
C
Y
E
H
Q
R
V
Y
T
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
-
P
G
E
D
-----
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
-
N
F
-
V
--
S
S
K
-----
G
-
Y
--
P
-------------
R
Y
C
T
VTTLSDVVLNGGR--
S
---------------
R
--------------
R
----
G
-
K
-
L
--
R
--------
G
P-
P
E
S
---
R
E
W
--------------
G
------------------
N
-
A
L
----------
K
-
G
C
D
D
-------------
P
L-----------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
------------------------------------------------------------------------------------------------------------------------
251
Fugue
78.71
51%
-65
- C1 -
-
3K2L
-
DYRK2_HUMAN
A:
[11-420]
-----------------
V
D
L
G
T
E
N
L
Y
F
M
G
K
V
K
A
T
P
-
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
-
R
Q
G
M
T
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
-
V
H
Q
-
H
-
V
A
L
K
-------
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
-------
M
N
V
I
H
M
L
E
N
F
T
-------
F
R
N
----
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
-
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
K
N
-
R
--
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
K
Q
----
Q
G
-----------------
R
S
-----------------
G
I
K
V
I
D
F
G
------
S
S
C
Y
E
H
Q
--
R
V
-
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
-
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
-
P
G
E
D
-----
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
Q
-
K
L
L
D
A
S
K
R
A
K
-
N
F
-
V
--
S
K
G
YP---
R
-
Y
--
C
-------------
T
V
T
T
---------------
L
---------------
S
--------------
D
----
G
-
S
-
V
--
V
--------
L
--
N
G
G
---
R
S
R
RGKLRGPPESREWG
N
------------------
A
-
L
K
----------
G
-
C
D
D
P
-------------
L
------------------
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
L
P
K
P
P
-----------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
75.41
44%
-82
- C1 -
-
4YLJ
5
DYR1A_HUMAN
B:
[34-357]
-------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
-
E
Q
E
-
W
-
V
A
I
K
-------
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-------
Y
Y
I
V
H
L
K
R
H
F
M
-------
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
-
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
P
-
E
LS
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
C
N
----
P
K
-----------------
R
S
-----------------
A
I
K
I
V
D
F
G
------
S
S
C
Q
L
G
Q
R
I
Y
Q
-
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
-
S
G
A
N
-----
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
-
K
F
-
F
--
E
K
--------
L
--
P
-------------
D
G
T
W
---------------
N
---------------
L
--------------
K
KTKD
G
-
K
-
R
--
E
--------
Y
KP
P
G
T
---
R
K
L
--------------
H
------------------
N
-
I
L
----------
G
-
V
E
T
G
-------------
G
PGGRRAGESGHTVADYLK
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
-----------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
74.40
44%
-76
- C1 -
-
6A1F
2
DYR1A_HUMAN
A:
[35-359]
-------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
-
E
Q
E
-
W
-
V
A
I
K
-------
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-------
Y
Y
I
V
H
L
K
R
H
F
M
-------
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
-
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
P
-
E
LS
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
C
N
----
P
K
-----------------
R
S
-----------------
A
I
K
I
V
D
F
G
------
S
S
C
Q
L
G
Q
R
I
Y
Q
-
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
-
S
G
A
N
-----
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
-
K
F
-
F
--
E
K
--------
L
--
P
-------------
D
G
T
W
---------------
N
---------------
L
--------------
K
KTK--------
E
--------
Y
KP
P
G
T
---
R
K
L
--------------
H
------------------
N
-
I
L
----------
G
-
V
E
T
G
-------------
G
PGGRRAGESGHTVADYLK
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
T
----------------------------------------------------------------------------------------------------------------------
98
Blastp_CBE
73.74
44%
-78
- C1 -
-
6S17
8
DYR1A_HUMAN
A:
[34-358]
-------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
-
E
Q
E
-
W
-
V
A
I
K
-------
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-------
Y
Y
I
V
H
L
K
R
H
F
M
-------
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
-
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
P
-
E
LS
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
C
N
----
P
K
-----------------
R
S
-----------------
A
I
K
I
V
D
F
G
------
S
S
C
Q
L
G
Q
R
I
Y
Q
-
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
-
S
G
A
N
-----
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
-
K
F
-
F
--
E
K
--------
L
--
P
-------------
D
G
T
W
---------------
N
---------------
L
--------------
K
K----------
E
--------
Y
KP
P
G
T
---
R
K
L
--------------
H
------------------
N
-
I
L
----------
G
-
V
E
T
G
-------------
G
PGGRRAGESGHTVADYLK
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
T
----------------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
72.95
44%
-84
- C1 -
-
6S1H
4
DYR1A_HUMAN
A:
[34-355]
-------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
-
E
Q
E
-
W
-
V
A
I
K
-------
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-------
Y
Y
I
V
H
L
K
R
H
F
M
-------
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
-
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
P
-
E
LS
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
C
N
----
P
K
-----------------
R
S
-----------------
A
I
K
I
V
D
F
G
------
S
S
C
Q
L
G
Q
R
I
Y
Q
-
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
-
S
G
A
N
-----
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
-
K
F
-
F
--
E
K
--------
L
--
P
-------------
D
G
T
W
---------------
N
---------------
L
--------------
K
K-------------------
Y
KP
P
G
T
---
R
K
L
--------------
H
------------------
N
-
I
L
----------
G
-
V
E
T
G
-------------
G
PGGRRAGESGHTVADYLK
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
-------------------------------------------------------------------------------------------------------------------------
244
HHSearch
72.73
45%
-78
- C1 -
-
6S1H
4
DYR1A_HUMAN
A:
[12-355]
---------------------------------------------------------------------------------
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
-
E
Q
E
-
W
-
V
A
I
K
-------
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-------
Y
Y
I
V
H
L
K
R
H
F
M
-------
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
-
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
AT
P
E
L
-
S
--
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
C
N
----
P
K
-----------------
R
S
-----------------
A
I
K
I
V
D
F
G
------
S
S
C
Q
L
G
Q
R
I
Y
Q
-
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
-
S
G
A
N
-----
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
-
K
F
-
F
--
E
K
L
-----
P
-
D
GT
W
-------------
N
L
K
K
-------------------------------------------------------
Y
--
K
--------
P
--
P
G
T
---
R
K
L
--------------
H
NILGVETGGPGGRRAGES
G
-
H
T
----------
V
-
A
D
Y
L
-------------
K
------------------
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
-------------------------------------------------------------------------------------------------------------------------
99
Blastp_CBE
72.37
44%
-81
- C1 -
-
6S14
1
DYR1A_HUMAN
A:
[34-357]
-------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
-
E
Q
E
-
W
-
V
A
I
K
-------
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-------
Y
Y
I
V
H
L
K
R
H
F
M
-------
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
-
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
P
-
E
LS
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
C
N
----
P
K
-----------------
R
S
-----------------
A
I
K
I
V
D
F
G
------
S
S
C
Q
L
G
Q
R
I
Y
Q
-
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
-
S
G
A
N
-----
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
-
K
F
-
F
--
E
K
--------
L
--
P
-------------
D
G
T
W
---------------
N
---------------
L
--------------
K
K-------------------
Y
KP
P
G
T
---
R
K
L
--------------
H
------------------
N
-
I
L
----------
G
-
V
E
T
G
-------------
G
PGGRRAGESGHTVADYLK
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
-----------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
72.36
44%
-76
- C1 -
-
4YLK
13
DYR1A_HUMAN
A:
[34-357]
-------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
-
E
Q
E
-
W
-
V
A
I
K
-------
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-------
Y
Y
I
V
H
L
K
R
H
F
M
-------
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
-
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
P
-
E
LS
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
C
N
----
P
K
-----------------
R
S
-----------------
A
I
K
I
V
D
F
G
------
S
S
C
Q
L
G
Q
R
I
Y
Q
-
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
-
S
G
A
N
-----
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
-
K
F
-
F
--
E
K
--------
L
--
P
-------------
D
G
T
W
---------------
N
---------------
L
--------------
K
K----------
E
--------
Y
KP
P
G
T
---
R
K
L
--------------
H
------------------
N
-
I
L
----------
G
-
V
E
T
G
-------------
G
PGGRRAGESGHTVADYLK
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
-----------------------------------------------------------------------------------------------------------------------
97
Blastp_CBE
72.29
44%
-78
- C1 -
-
6S1B
2
DYR1A_HUMAN
A:
[34-357]
-------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
-
E
Q
E
-
W
-
V
A
I
K
-------
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-------
Y
Y
I
V
H
L
K
R
H
F
M
-------
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
-
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
P
-
E
LS
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
C
N
----
P
K
-----------------
R
S
-----------------
A
I
K
I
V
D
F
G
------
S
S
C
Q
L
G
Q
R
I
Y
Q
-
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
-
S
G
A
N
-----
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
-
K
F
-
F
--
E
K
-------------------------
D
G
T
W
---------------
N
---------------
L
--------------
K
K-------------------
Y
KP
P
G
T
---
R
K
L
--------------
H
------------------
N
-
I
L
----------
G
-
V
E
T
G
-------------
G
PGGRRAGESGHTVADYLK
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
-----------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
72.13
44%
-71
- C1 -
-
2WO6
1
DYR1A_HUMAN
B:
[55-377]
-------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
-
E
Q
E
-
W
-
V
A
I
K
-------
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-------
Y
Y
I
V
H
L
K
R
H
F
M
-------
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
-
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
P
-
E
LS
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
C
N
----
P
K
-----------------
R
S
-----------------
A
I
K
I
V
D
F
G
------
S
S
C
Q
L
G
Q
R
I
Y
Q
-
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
-
S
G
A
N
-----
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
-
K
F
-
F
--
E
K
--------
L
--
P
-------------
D
G
T
W
---------------
N
---------------
L
--------------
K
------
K
-
R
--
E
--------
Y
KP
P
G
T
---
R
K
L
--------------
H
------------------
N
-
I
L
----------
G
-
V
E
T
G
-------------
G
PGGRRAGESGHTVADYLK
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
72.08
44%
-81
- C1 -
-
6S1J
8
DYR1A_HUMAN
A:
[34-356]
-------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
-
E
Q
E
-
W
-
V
A
I
K
-------
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-------
Y
Y
I
V
H
L
K
R
H
F
M
-------
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
-
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
P
-
E
LS
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
C
N
----
P
K
-----------------
R
S
-----------------
A
I
K
I
V
D
F
G
------
S
S
C
Q
L
G
Q
R
I
Y
Q
-
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
-
S
G
A
N
-----
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
-
K
F
-
F
--
E
K
--------
L
--
P
-------------
D
G
T
W
---------------
N
---------------
L
--------------
K
K-------------------
Y
KP
P
G
T
---
R
K
L
--------------
H
------------------
N
-
I
L
----------
G
-
V
E
T
G
-------------
G
PGGRRAGESGHTVADYLK
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
------------------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
71.89
44%
-76
- C1 -
-
2WO6
1
DYR1A_HUMAN
A:
[55-378]
-------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
-
E
Q
E
-
W
-
V
A
I
K
-------
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-------
Y
Y
I
V
H
L
K
R
H
F
M
-------
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
-
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
P
-
E
LS
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
C
N
----
P
K
-----------------
R
S
-----------------
A
I
K
I
V
D
F
G
------
S
S
C
Q
L
G
Q
R
I
Y
Q
-
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
-
S
G
A
N
-----
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
-
K
F
-
F
--
E
K
--------
L
--
P
-------------
D
G
T
W
---------------
N
---------------
L
--------------
K
KT------
R
--
E
--------
Y
KP
P
G
T
---
R
K
L
--------------
H
------------------
N
-
I
L
----------
G
-
V
E
T
G
-------------
G
PGGRRAGESGHTVADYLK
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
-----------------------------------------------------------------------------------------------------------------------
101
Blastp_CBE
71.72
44%
-78
- C1 -
-
6S11
1
DYR1A_HUMAN
A:
[34-356]
-------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
-
E
Q
E
-
W
-
V
A
I
K
-------
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-------
Y
Y
I
V
H
L
K
R
H
F
M
-------
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
-
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
P
-
E
LS
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
C
N
----
P
K
-----------------
R
S
-----------------
A
I
K
I
V
D
F
G
------
S
S
C
Q
L
G
Q
R
I
Y
Q
-
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
-
S
G
A
N
-----
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
-
K
F
-
F
--
E
K
--------
L
--
P
-------------
D
G
T
W
---------------
N
---------------
L
--------------
K
KT----
K
-
R
--
E
--------
Y
KP
P
G
T
---
R
K
L
--------------
H
------------------
N
-
I
L
----------
G
-
V
E
T
G
-------------
G
PGGRRAGESGHTVADYLK
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
71.52
44%
-71
- C1 -
-
6A1G
1
DYR1A_HUMAN
B:
[35-357]
-------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
-
E
Q
E
-
W
-
V
A
I
K
-------
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-------
Y
Y
I
V
H
L
K
R
H
F
M
-------
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
-
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
P
-
E
LS
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
C
N
----
P
K
-----------------
R
S
-----------------
A
I
K
I
V
D
F
G
------
S
S
C
Q
L
G
Q
R
I
Y
Q
-
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
-
S
G
A
N
-----
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
-
K
F
-
F
--
E
K
--------
L
--
P
-------------
D
G
T
W
---------------
N
---------------
L
--------------
K
--------------------
Y
KP
P
G
T
---
R
K
L
--------------
H
------------------
N
-
I
L
----------
G
-
V
E
T
G
-------------
G
PGGRRAGESGHTVADYLK
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
------------------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
70.92
44%
-77
- C1 -
-
4YLL
10
DYR1A_HUMAN
A:
[34-357]
-------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
-
E
Q
E
-
W
-
V
A
I
K
-------
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
-
K
-------
Y
Y
I
V
H
L
K
R
H
F
M
-------
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
-
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
P
-
E
LS
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
C
N
----
P
K
-----------------
R
S
-----------------
A
I
K
I
V
D
F
G
------
S
S
C
Q
L
G
Q
R
I
Y
Q
-
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
-
S
G
A
N
-----
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
-
K
F
-
F
--
E
K
--------
L
--
P
-------------
D
G
T
W
---------------
N
---------------
L
--------------
K
K----------
E
--------
Y
KP
P
G
T
---
R
K
L
--------------
H
------------------
N
-
I
L
----------
G
-
V
E
T
G
-------------
G
PGGRRAGESGHTVADYLK
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
-----------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
69.35
44%
-76
- C1 -
-
6A1G
1
DYR1A_HUMAN
A:
[35-357]
-------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
-
E
Q
E
-
W
-
V
A
I
K
-------
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-------
Y
Y
I
V
H
L
K
R
H
F
M
-------
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
-
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
P
-
E
LS
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
C
N
-----------------------
R
S
-----------------
A
I
K
I
V
D
F
G
------
S
S
C
Q
L
G
Q
R
I
Y
Q
-
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
-
S
G
A
N
-----
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
-
K
F
-
F
--
E
K
--------
L
--
P
-------------
D
G
T
W
---------------
N
---------------
L
--------------
K
-----------
E
--------
Y
KP
P
G
T
---
R
K
L
--------------
H
------------------
N
-
I
L
----------
G
-
V
E
T
G
-------------
G
PGGRRAGESGHTVADYLK
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
65.19
34%
-44
- C1 -
-
6FYR
1
CLK3_HUMAN
A:
[9-356]
---------------------------------------------------------------------------------
S
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
-
G
K
S
-
Q
-
V
A
L
K
-------
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-------
F
L
C
V
L
M
S
D
W
F
N
-------
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
-
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
E
N
-
Q
--
L
T
H
T
D
L
K
P
E
N
I
L
FVNSEFET
L
-----------------------
Y
N
----
E
H
-----------------
K
S
CEEKSVKNT--------
S
I
R
V
A
D
F
G
------
S
A
T
F
D
H
E
H
H
T
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
-
Q
T
H
E
-----
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
-
T
R
K
Q
-
K
Y
-
F
--
Y
K
G
-----
G
-
L
--
V
-------------
W
D
E
N
---------------
S
---------------
S
--------------
D
----
G
-
R
-
Y
--
V
--------
K
--
E
N
C
---
K
P
L
--------------
K
------------------
S
-
Y
M
LQD-------
S
-
L
E
H
V
-------------
Q
------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
---
A
G
L
T
P
E
E
R
--------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
64.81
34%
-49
- C1 -
-
6RCT
7
CLK3_HUMAN
B:
[10-356]
----------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
-
G
K
S
-
Q
-
V
A
L
K
-------
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-------
F
L
C
V
L
M
S
D
W
F
N
-------
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
-
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
E
N
-
Q
--
L
T
H
T
D
L
K
P
E
N
I
L
FVNSEFET
L
-----------------------
Y
N
----
E
H
-----------------
K
S
CEEKSVKNT--------
S
I
R
V
A
D
F
G
------
S
A
T
F
D
H
E
H
H
T
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
-
Q
T
H
E
-----
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
-
T
R
K
Q
-
K
Y
-
F
--
Y
K
G
-----
G
-
L
--
V
-------------
W
D
E
N
---------------
S
---------------
S
--------------
D
----
G
-
R
-
Y
--
V
--------
K
--
E
N
C
---
K
P
L
--------------
K
------------------
S
-
Y
M
LQD-------
S
-
L
E
H
V
-------------
Q
------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
---
A
G
L
T
P
E
E
R
--------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
64.73
33%
-46
- C1 -
-
2WU6
7
CLK3_HUMAN
A:
[31-377]
----------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
-
G
K
S
-
Q
-
V
A
L
K
-------
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-------
F
L
C
V
L
M
S
D
W
F
N
-------
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
-
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
E
N
-
Q
--
L
T
H
T
D
L
K
P
E
N
I
L
FVNSEFET
L
-----------------------
Y
N
----
E
H
-----------------
K
S
CEEKSVKNT--------
S
I
R
V
A
D
F
G
------
S
A
T
F
D
H
E
H
H
T
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
-
Q
T
H
E
-----
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
-
T
R
K
Q
-
K
Y
-
F
--
Y
K
G
-----
G
-
L
--
V
-------------
W
D
E
N
---------------
S
---------------
S
--------------
D
----
G
-
R
-
Y
--
V
--------
K
--
E
N
C
---
K
P
L
--------------
K
------------------
S
-
Y
M
LQD-------
S
-
L
E
H
V
-------------
Q
------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
---
A
G
L
T
P
E
E
R
--------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
64.50
34%
-49
- C1 -
-
6RCT
8
CLK3_HUMAN
A:
[11-356]
-----------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
-
G
K
S
-
Q
-
V
A
L
K
-------
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-------
F
L
C
V
L
M
S
D
W
F
N
-------
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
-
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
E
N
-
Q
--
L
T
H
T
D
L
K
P
E
N
I
L
FVNSEFET
L
-----------------------
Y
N
----
E
H
-----------------
K
S
CEEKSVKNT--------
S
I
R
V
A
D
F
G
------
S
A
T
F
D
H
E
H
H
T
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
-
Q
T
H
E
-----
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
-
T
R
K
Q
-
K
Y
-
F
--
Y
K
G
-----
G
-
L
--
V
-------------
W
D
E
N
---------------
S
---------------
S
--------------
D
----
G
-
R
-
Y
--
V
--------
K
--
E
N
C
---
K
P
L
--------------
K
------------------
S
-
Y
M
LQD-------
S
-
L
E
H
V
-------------
Q
------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
---
A
G
L
T
P
E
E
R
--------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
64.30
34%
-43
- C1 -
-
6FT7
7
CLK3_HUMAN
A:
[9-356]
---------------------------------------------------------------------------------
S
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
-
G
K
S
-
Q
-
V
A
L
K
-------
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-------
F
L
C
V
L
M
S
D
W
F
N
-------
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
-
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
E
N
-
Q
--
L
T
H
T
D
L
K
P
E
N
I
L
FVNSEFET
L
-----------------------
Y
N
----
E
H
-----------------
K
S
CEEKSVKNT--------
S
I
R
V
A
D
F
G
------
S
A
T
F
D
H
E
H
H
T
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
-
Q
T
H
E
-----
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
-
T
R
K
Q
-
K
Y
-
F
--
Y
K
G
-----
G
-
L
--
V
-------------
W
D
E
N
---------------
S
---------------
S
--------------
D
----
G
-
R
-
Y
--
V
--------
K
--
E
N
C
---
K
P
L
--------------
K
------------------
S
-
Y
M
LQD-------
S
-
L
E
H
V
-------------
Q
------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
---
A
G
L
T
P
E
E
R
--------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
64.00
33%
-47
- C1 -
-
2WU7
1
CLK3_HUMAN
A:
[32-377]
-----------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
-
G
K
S
-
Q
-
V
A
L
K
-------
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-------
F
L
C
V
L
M
S
D
W
F
N
-------
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
-
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
E
N
-
Q
--
L
T
H
T
D
L
K
P
E
N
I
L
FVNSEFET
L
-----------------------
Y
N
----
E
H
-----------------
K
S
CEEKSVKNT--------
S
I
R
V
A
D
F
G
------
S
A
T
F
D
H
E
H
H
T
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
-
Q
T
H
E
-----
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
-
T
R
K
Q
-
K
Y
-
F
--
Y
K
G
-----
G
-
L
--
V
-------------
W
D
E
N
---------------
S
---------------
S
--------------
D
----
G
-
R
-
Y
--
V
--------
K
--
E
N
C
---
K
P
L
--------------
K
------------------
S
-
Y
M
LQD-------
S
-
L
E
H
V
-------------
Q
------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
---
A
G
L
T
P
E
E
R
--------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
63.98
33%
-48
- C1 -
-
3RAW
1
CLK3_HUMAN
B:
[33-377]
------------------------------------------------------------------------------------
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
-
G
K
S
-
Q
-
V
A
L
K
-------
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-------
F
L
C
V
L
M
S
D
W
F
N
-------
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
-
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
E
N
-
Q
--
L
T
H
T
D
L
K
P
E
N
I
L
FVNSEFET
L
-----------------------
Y
N
----
E
H
-----------------
K
S
CEEKSVKNT--------
S
I
R
V
A
D
F
G
------
S
A
T
F
D
H
E
H
H
T
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
-
Q
T
H
E
-----
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
-
T
R
K
Q
-
K
Y
-
F
--
Y
K
G
-----
G
-
L
--
V
-------------
W
D
E
N
---------------
S
---------------
S
--------------
D
----
G
-
R
-
Y
--
V
--------
K
--
E
N
C
---
K
P
L
--------------
K
------------------
S
-
Y
M
LQD-------
S
-
L
E
H
V
-------------
Q
------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
---
A
G
L
T
P
E
E
R
--------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
63.45
34%
-45
- C1 -
-
6FT7
8
CLK3_HUMAN
B:
[9-356]
---------------------------------------------------------------------------------
S
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
-
G
K
S
-
Q
-
V
A
L
K
-------
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-------
F
L
C
V
L
M
S
D
W
F
N
-------
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
-
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
E
N
-
Q
--
L
T
H
T
D
L
K
P
E
N
I
L
FVNSEFET
L
-----------------------
Y
N
----
E
H
-----------------
K
S
CEEKSVKNT--------
S
I
R
V
A
D
F
G
------
S
A
T
F
D
H
E
H
H
T
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
-
Q
T
H
E
-----
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
-
T
R
K
Q
-
K
Y
-
F
--
Y
K
G
-----
G
-
L
--
V
-------------
W
D
E
N
---------------
S
---------------
S
--------------
D
----
G
-
R
-
Y
--
V
--------
K
--
E
N
C
---
K
P
L
--------------
K
------------------
S
-
Y
M
LQD-------
S
-
L
E
H
V
-------------
Q
------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
---
A
G
L
T
P
E
E
R
--------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
63.38
34%
-45
- C1 -
-
6FYP
1
CLK3_HUMAN
A:
[11-356]
-----------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
-
G
K
S
-
Q
-
V
A
L
K
-------
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-------
F
L
C
V
L
M
S
D
W
F
N
-------
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
-
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
E
N
-
Q
--
L
T
H
T
D
L
K
P
E
N
I
L
FVNSEFET
L
-----------------------
Y
N
----
E
H
-----------------
K
S
CEEKSVKNT--------
S
I
R
V
A
D
F
G
------
S
A
T
F
D
H
E
H
H
T
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
-
Q
T
H
E
-----
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
-
T
R
K
Q
-
K
Y
-
F
--
Y
K
G
-----
G
-
L
--
V
-------------
W
D
E
N
---------------
S
---------------
S
--------------
D
----
G
-
R
-
Y
--
V
--------
K
--
E
N
C
---
K
P
L
--------------
K
------------------
S
-
Y
M
LQD-------
S
-
L
E
H
V
-------------
Q
------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
---
A
G
L
T
P
E
E
R
--------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
63.36
33%
-46
- C1 -
-
3RAW
1
CLK3_HUMAN
A:
[31-377]
----------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
-
G
K
S
-
Q
-
V
A
L
K
-------
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-------
F
L
C
V
L
M
S
D
W
F
N
-------
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
-
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
E
N
-
Q
--
L
T
H
T
D
L
K
P
E
N
I
L
FVNSEFET
L
-----------------------
Y
N
----
E
H
-----------------
K
S
CEEKSVKNT--------
S
I
R
V
A
D
F
G
------
S
A
T
F
D
H
E
H
H
T
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
-
Q
T
H
E
-----
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
-
T
R
K
Q
-
K
Y
-
F
--
Y
K
G
-----
G
-
L
--
V
-------------
W
D
E
N
---------------
S
---------------
S
--------------
D
----
G
-
R
-
Y
--
V
--------
K
--
E
N
C
---
K
P
L
--------------
K
------------------
S
-
Y
M
LQD-------
S
-
L
E
H
V
-------------
Q
------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
---
A
G
L
T
P
E
E
R
--------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
63.29
33%
-61
- C1 -
-
6G33
1
CLK1_HUMAN
A:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
63.19
45%
-80
- C1 -
-
4AZE
1
DYR1A_HUMAN
B:
[55-378]
-------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
-
E
Q
E
-
W
-
V
A
I
K
-------
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-------
Y
Y
I
V
H
L
K
R
H
F
M
-------
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
-
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
P
-
E
LS
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
C
N
----
P
K
-----------------
R
A
------------------
I
K
I
V
D
F
G
------
S
S
C
Q
L
G
Q
R
I
Y
Q
--
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
-
S
G
A
N
-----
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
-
K
F
-
F
--
E
K
--------
L
--
P
-------------
D
G
T
W
---------------
N
---------------
L
--------------
K
KTKD
G
-
K
-
R
--
E
--------
Y
KP
P
G
T
---
R
K
L
--------------
H
------------------
N
-
I
L
----------
G
-
V
E
T
G
-------------
G
PGGRRAGESGHTVADYLK
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
T
----------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
62.96
45%
-80
- C1 -
-
4AZE
1
DYR1A_HUMAN
C:
[55-378]
-------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
-
E
Q
E
-
W
-
V
A
I
K
-------
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-------
Y
Y
I
V
H
L
K
R
H
F
M
-------
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
-
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
P
-
E
LS
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
C
N
----
P
K
-----------------
R
A
------------------
I
K
I
V
D
F
G
------
S
S
C
Q
L
G
Q
R
I
Y
Q
--
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
-
S
G
A
N
-----
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
-
K
F
-
F
--
E
K
--------
L
--
P
-------------
D
G
T
W
---------------
N
---------------
L
--------------
K
KTKD
G
-
K
-
R
--
E
--------
Y
KP
P
G
T
---
R
K
L
--------------
H
------------------
N
-
I
L
----------
G
-
V
E
T
G
-------------
G
PGGRRAGESGHTVADYLK
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
T
----------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
62.87
33%
-61
- C1 -
-
6I5L
2
CLK1_HUMAN
B:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
157
Blastp_CBE
62.67
32%
-54
- C1 -
-
3NR9
1
CLK2_HUMAN
C:
[17-355]
--------------------------------------------------------------------------------------
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
-
V
A
L
K
-------
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
-------
N
L
C
V
Q
M
F
D
W
F
D
-------
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
-
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
D
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
N
----
S
D
YELTYNLEKKRDERSVK
S
T
-----------------
A
V
R
V
V
D
F
G
------
S
A
T
F
D
H
E
H
H
S
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
-
Q
T
H
D
-----
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
-
Y
F
-
Y
--
R
G
R
------------------------
L
D
W
D
---------------
E
---------------
N
--------------
T
----
S
-
A
-
G
--
R
--------
Y
----
V
---
R
E
N
--------------
C
------------------
K
-
P
L
----------
R
-
R
Y
L
T
-------------
S
EAEEHHQ-----------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---------------------------------------------------------------------------------------------------------------------
159
Blastp_CBE
62.66
32%
-54
- C1 -
-
3NR9
1
CLK2_HUMAN
A:
[17-356]
--------------------------------------------------------------------------------------
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
-
V
A
L
K
-------
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
-------
N
L
C
V
Q
M
F
D
W
F
D
-------
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
-
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
D
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
N
----
S
D
YELTDERSVK-------
S
T
-----------------
A
V
R
V
V
D
F
G
------
S
A
T
F
D
H
E
H
H
S
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
-
Q
T
H
D
-----
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
-
Y
F
-
Y
--
R
G
R
------------------------
L
D
W
D
---------------
E
---------------
N
--------------
T
----
S
-
A
-
G
--
R
--------
Y
----
V
---
R
E
N
--------------
C
------------------
K
-
P
L
----------
R
-
R
Y
L
T
-------------
S
EAEEHHQ-----------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
--------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
62.55
45%
-79
- C1 -
-
4AZE
1
DYR1A_HUMAN
A:
[55-378]
-------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
-
E
Q
E
-
W
-
V
A
I
K
-------
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-------
Y
Y
I
V
H
L
K
R
H
F
M
-------
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
-
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
P
-
E
LS
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
C
N
----
P
K
-----------------
R
A
------------------
I
K
I
V
D
F
G
------
S
S
C
Q
L
G
Q
R
I
Y
Q
--
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
-
S
G
A
N
-----
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
-
K
F
-
F
--
E
K
--------
L
--
P
-------------
D
G
T
W
---------------
N
---------------
L
--------------
K
KTKD
G
-
K
-
R
--
E
--------
Y
KP
P
G
T
---
R
K
L
--------------
H
------------------
N
-
I
L
----------
G
-
V
E
T
G
-------------
G
PGGRRAGESGHTVADYLK
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
T
----------------------------------------------------------------------------------------------------------------------
100
Blastp_CBE
62.54
44%
-83
- C1 -
-
6S11
1
DYR1A_HUMAN
B:
[34-356]
-------------------------------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
-
E
Q
E
-
W
-
V
A
I
K
-------
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
-------
Y
Y
I
V
H
L
K
R
H
F
M
-------
F
R
N
----
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
-
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
T
P
-
E
LS
I
I
H
C
D
L
K
P
E
N
I
L
--------
L
-----------------------
C
N
----
P
K
-----------------
R
S
-----------------
A
I
K
I
V
D
F
G
------
S
S
C
Q
L
G
Q
R
I
----
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
-
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
-
S
G
A
N
-----
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
-
K
F
-
F
--
E
K
--------
L
--
P
-------------
D
G
T
W
---------------
N
---------------
L
--------------
K
--------------------
Y
KP
P
G
T
---
R
K
L
--------------
H
------------------
N
-
I
L
----------
G
-
V
-
T
G
-------------
G
PGGRESGHTVADYLK---
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
------------------------------------------------------------------------------------------------------------------------
175
Blastp_CBE
62.41
33%
-60
- C1 -
-
6FT9
2
CLK1_HUMAN
C:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
62.40
32%
-55
- C1 -
-
3NR9
1
CLK2_HUMAN
B:
[17-354]
--------------------------------------------------------------------------------------
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
-
V
A
L
K
-------
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
-------
N
L
C
V
Q
M
F
D
W
F
D
-------
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
-
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
D
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
N
----
S
D
YELTYNLEKKRDERSVK
S
T
-----------------
A
V
R
V
V
D
F
G
------
S
A
T
F
D
H
E
H
H
S
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
-
Q
T
H
D
-----
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
-
Y
F
-
Y
--
R
G
R
------------------------
L
D
W
D
---------------
E
---------------
N
--------------
T
----
S
-
A
-
G
--
R
--------
Y
----
V
---
R
E
N
--------------
C
------------------
K
-
P
L
----------
R
-
R
Y
L
T
-------------
S
EAEEHHQ-----------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
----------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
62.35
33%
-60
- C1 -
-
6I5L
4
CLK1_HUMAN
C:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
62.31
33%
-60
- C1 -
-
6RAA
2
CLK1_HUMAN
A:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
169
Blastp_CBE
62.26
33%
-57
- C1 -
-
6I5K
5
CLK1_HUMAN
B:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
62.24
33%
-61
- C1 -
-
6FT8
7
CLK1_HUMAN
A:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
168
Blastp_CBE
62.20
33%
-58
- C1 -
-
6I5K
3
CLK1_HUMAN
C:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
62.20
32%
-52
- C1 -
-
5UNP
1
CLK2_HUMAN
A:
[13-356]
---------------------------------------------------------------------------------
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
-
V
A
L
K
-------
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
-------
N
L
C
V
Q
M
F
D
W
F
D
-------
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
-
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
D
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
N
----
S
D
YELTYNLEKKRDERSVK
S
T
-----------------
A
V
R
V
V
D
F
G
------
S
A
T
F
D
H
E
H
H
S
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
-
Q
T
H
D
-----
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
-
Y
F
-
Y
--
R
G
R
------------------------
L
D
W
D
---------------
E
---------------
N
--------------
T
----
S
-
A
-
G
--
R
--------
Y
----
V
---
R
E
N
--------------
C
------------------
K
-
P
L
----------
R
-
R
Y
L
T
-------------
S
EAEEHHQ-----------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---------------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
62.13
32%
-52
- C1 -
-
5UNP
1
CLK2_HUMAN
B:
[13-356]
---------------------------------------------------------------------------------
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
-
V
A
L
K
-------
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
-------
N
L
C
V
Q
M
F
D
W
F
D
-------
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
-
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
D
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
N
----
S
D
YELTYNLEKKRDERSVK
S
T
-----------------
A
V
R
V
V
D
F
G
------
S
A
T
F
D
H
E
H
H
S
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
-
Q
T
H
D
-----
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
-
Y
F
-
Y
--
R
G
R
------------------------
L
D
W
D
---------------
E
---------------
N
--------------
T
----
S
-
A
-
G
--
R
--------
Y
----
V
---
R
E
N
--------------
C
------------------
K
-
P
L
----------
R
-
R
Y
L
T
-------------
S
EAEEHHQ-----------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
62.05
33%
-60
- C1 -
-
6FT9
2
CLK1_HUMAN
B:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
164
Blastp_CBE
62.00
33%
-61
- C1 -
-
6Q8K
2
CLK1_HUMAN
A:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
61.94
32%
-49
- C1 -
-
6FYK
1
CLK2_HUMAN
B:
[7-352]
---------------------------------------------------------------------------------
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
-
V
A
L
K
-------
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
-------
N
L
C
V
Q
M
F
D
W
F
D
-------
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
-
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
D
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
N
----
S
D
YELTYNLEKKRDERSVK
S
T
-----------------
A
V
R
V
V
D
F
G
------
S
A
T
F
D
H
E
H
H
S
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
-
Q
T
H
D
-----
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
-
Y
F
-
Y
--
R
G
R
------------------------
L
D
W
D
---------------
E
---------------
N
--------------
T
----
S
-
A
-
G
--
R
--------
Y
----
V
---
R
E
N
--------------
C
------------------
K
-
P
L
----------
R
-
R
Y
L
T
-------------
S
EAEEHHQ-----------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
E
-------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
61.89
32%
-48
- C1 -
-
6FYK
1
CLK2_HUMAN
C:
[7-352]
---------------------------------------------------------------------------------
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
-
V
A
L
K
-------
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
-------
N
L
C
V
Q
M
F
D
W
F
D
-------
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
-
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
D
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
N
----
S
D
YELTYNLEKKRDERSVK
S
T
-----------------
A
V
R
V
V
D
F
G
------
S
A
T
F
D
H
E
H
H
S
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
-
Q
T
H
D
-----
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
-
Y
F
-
Y
--
R
G
R
------------------------
L
D
W
D
---------------
E
---------------
N
--------------
T
----
S
-
A
-
G
--
R
--------
Y
----
V
---
R
E
N
--------------
C
------------------
K
-
P
L
----------
R
-
R
Y
L
T
-------------
S
EAEEHHQ-----------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
E
-------------------------------------------------------------------------------------------------------------------
177
Blastp_CBE
61.84
33%
-59
- C1 -
-
6FT9
4
CLK1_HUMAN
A:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
155
Blastp_CBE
61.76
33%
-47
- C1 -
-
6FYO
1
CLK1_HUMAN
A:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
YTEAYNKRDERTLI---
N
P
-----------------
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
-
Y
F
H
H
--
D
R
L
-----
D
-
W
--
D
-------------
E
H
S
S
---------------
A
---------------
G
--------------
R
Y---
V
-
S
-
R
--
R
--------
C
--
K
P
L
---
K
E
F
--------------
M
------------------
L
-
S
Q
----------
D
-
V
E
H
E
-------------
R
------------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
61.69
33%
-58
- C1 -
-
5J1W
6
CLK1_HUMAN
A:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
170
Blastp_CBE
61.65
33%
-57
- C1 -
-
6I5K
3
CLK1_HUMAN
A:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
207
Blastp_CBE
61.62
31%
-67
- C1 -
-
3LLT
1
?
A:
[39-359]
----------------------------------------------------------------------------------------------------------
V
I
R
K
M
G
D
G
T
F
G
R
V
L
L
C
Q
H
-
I
-
D
-
N
K
K
-
Y
-
Y
A
V
K
-------
V
V
R
N
I
K
K
Y
T
R
S
A
K
I
E
A
D
I
L
K
K
I
Q
N
D
D
I
N
N
N
-------
N
I
V
K
Y
H
G
K
F
M
Y
-------
Y
-
D
----
H
M
C
L
I
F
E
P
L
G
P
S
L
Y
E
I
I
T
R
N
N
Y
N
-
G
F
H
I
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
--
R
K
M
-
S
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
L
DDPYFEKSLITVRRVTDGKKIQI
Y
R
----
T
K
-----------------
S
T
-----------------
G
I
K
L
I
D
F
G
------
C
A
T
F
K
S
D
Y
H
G
S
-
I
I
N
T
R
Q
Y
R
A
P
E
V
I
L
N
-
L
G
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
G
S
L
L
F
-
R
T
H
E
-----
H
M
E
H
L
A
M
M
E
S
I
I
Q
P
I
P
K
N
M
L
Y
E
A
T
K
T
N
G
S
K
-
Y
--
V
N
K
DELKL
A
-
W
--
P
-------------
E
N
A
S
---------------
S
---------------
I
--------------
N
----
S
-
I
-
K
--
H
--------
V
--
K
K
C
---
L
P
L
--------------
Y
------------------
K
-
I
I
----------
K
---
H
E
-------------
L
------------------
F
C
D
F
L
Y
S
I
L
Q
I
D
P
T
L
R
P
S
P
A
E
L
L
K
H
K
F
L
-------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
61.54
32%
-49
- C1 -
-
6FYL
1
CLK2_HUMAN
A:
[11-350]
-------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
-
V
A
L
K
-------
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
-------
N
L
C
V
Q
M
F
D
W
F
D
-------
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
-
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
D
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
N
----
S
D
YELTYNLEKKRDERSVK
S
T
-----------------
A
V
R
V
V
D
F
G
------
S
A
T
F
D
H
E
H
H
S
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
-
Q
T
H
D
-----
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
-
Y
F
-
Y
--
R
G
R
------------------------
L
D
W
D
---------------
E
---------------
N
--------------
T
----
S
-
A
-
G
--
R
--------
Y
----
V
---
R
E
N
--------------
C
------------------
K
-
P
L
----------
R
-
R
Y
L
T
-------------
S
EAEEHHQ-----------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---------------------------------------------------------------------------------------------------------------------
180
Blastp_CBE
61.50
33%
-57
- C1 -
-
5J1W
3
CLK1_HUMAN
B:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
167
Blastp_CBE
61.49
33%
-62
- C1 -
-
6I5L
3
CLK1_HUMAN
A:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
61.31
33%
-57
- C1 -
-
1Z57
1
CLK1_HUMAN
A:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNRDERTLINP----
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
61.30
33%
-58
- C1 -
-
6Q8P
1
CLK1_HUMAN
A:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
-
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
61.28
32%
-47
- C1 -
-
6FYK
1
CLK2_HUMAN
A:
[7-352]
---------------------------------------------------------------------------------
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
-
V
A
L
K
-------
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
-------
N
L
C
V
Q
M
F
D
W
F
D
-------
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
-
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
D
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
N
----
S
D
YELTYNLEKKRDERSVK
S
T
-----------------
A
V
R
V
V
D
F
G
------
S
A
T
F
D
H
E
H
H
S
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
-
Q
T
H
D
-----
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
-
Y
F
-
Y
--
R
G
R
------------------------
L
D
W
D
---------------
E
---------------
N
--------------
T
----
S
-
A
-
G
--
R
--------
Y
----
V
---
R
E
N
--------------
C
------------------
K
-
P
L
----------
R
-
R
Y
L
T
-------------
S
EAEEHHQ-----------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
E
-------------------------------------------------------------------------------------------------------------------
236
HHSearch
61.19
35%
-45
- C1 -
-
6KHF
1
CLK3_HUMAN
A:
[144-475]
--------------------------------------------------------------------------------------------
L
V
C
R
I
G
D
W
L
Q
E
D
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
-
A
-
R
G
K
S
Q
-
V
A
L
K
-------
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-------
F
L
C
V
L
M
S
D
W
F
N
-------
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
-
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
E
N
-
Q
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
N
SEFS
V
K
-----------------
N
T
-----------------
S
I
R
V
A
D
F
G
------
S
A
T
F
D
H
E
H
H
T
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
-
Q
T
H
E
-----
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
Q
K
-
Y
F
-
Y
--
K
G
G
-----
L
-
V
--
W
D------------
E
N
S
S
---------------
D
---------------
G
--------------
R
Y---
V
-
K
-
E
--
N
--------
C
--
K
P
L
---
K
S
Y
--------------
M
------------------
L
-
Q
D
----------
S
-
L
E
H
V
-------------
Q
------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
----------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
61.17
33%
-57
- C1 -
-
6G33
1
CLK1_HUMAN
B:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
156
Blastp_CBE
61.03
32%
-53
- C1 -
-
6FYI
1
CLK2_HUMAN
A:
[20-355]
-----------------------------------------------------------------------------------------
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
-
V
A
L
K
-------
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
-------
N
L
C
V
Q
M
F
D
W
F
D
-------
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
-
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
D
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
N
----
S
D
YELTYNLEKKRDERSVK
S
T
-----------------
A
V
R
V
V
D
F
G
------
S
A
T
F
D
H
E
H
H
S
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
-
Q
T
H
D
-----
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
-
Y
F
-
Y
--
R
G
R
------------------------
L
D
W
D
---------------
E
---------------
N
--------------
T
----
S
-
A
-
G
--
R
--------
Y
----
V
---
R
E
N
--------------
C
------------------
K
-
P
L
----------
R
-
R
Y
L
T
-------------
S
EAEEHHQ-----------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
60.99
33%
-57
- C1 -
-
5J1V
2
CLK1_HUMAN
A:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
60.79
32%
-43
- C1 -
-
6FYV
1
CLK4_HUMAN
A:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
R
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
G
-
M
D
G
-
M
H
V
A
V
K
-------
I
V
K
N
V
G
R
Y
R
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
S
T
D
P
N
S
V
-------
F
R
C
V
Q
M
L
E
W
F
D
-------
H
H
G
----
H
V
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
S
F
L
-
P
F
Q
I
D
H
I
R
Q
M
A
Y
Q
I
C
Q
S
I
N
F
L
--
H
H
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
K
----
S
D
YVVKYNKRDERTLK---
N
T
-----------------
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
Q
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
I
P
Q
H
M
I
Q
K
T
R
K
R
K
-
Y
F
-
H
--
H
N
Q
L----
D
-
W
--
D
-------------
E
H
S
S
---------------
A
---------------
G
--------------
R
Y---
V
-
R
-
R
--
R
--------
C
--
K
P
L
---
K
E
F
--------------
M
------------------
L
-
C
H
----------
D
-
E
E
H
E
-------------
K
------------------
L
F
D
L
V
R
R
M
L
E
Y
D
P
T
Q
R
I
T
L
D
E
A
L
Q
H
----------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
60.78
33%
-57
- C1 -
-
6G33
1
CLK1_HUMAN
C:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
-
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
60.77
33%
-60
- C1 -
-
5X8I
1
CLK1_HUMAN
A:
[9-328]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
60.73
33%
-61
- C1 -
-
6I5I
13
CLK1_HUMAN
A:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
----------
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
60.64
33%
-60
- C1 -
-
5X8I
1
CLK1_HUMAN
B:
[9-328]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
60.44
33%
-53
- C1 -
-
6Q8P
1
CLK1_HUMAN
B:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPRDERTLINP---
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
--
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
183
Blastp_CBE
60.41
33%
-57
- C1 -
-
5J1V
1
CLK1_HUMAN
B:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
60.34
34%
-36
- C1 -
-
6KHF
1
CLK3_HUMAN
A:
[142-480]
------------------------------------------------------------------------------------------
G
H
L
V
C
R
I
G
D
W
L
Q
E
D
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
-
G
K
S
-
Q
-
V
A
L
K
-------
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
N
K
-------
F
L
C
V
L
M
S
D
W
F
N
-------
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
-
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
E
N
-
Q
--
L
T
H
T
D
L
K
P
E
N
I
L
FVNSEF-----------------------------------------------------SVKNT------------
S
I
R
V
A
D
F
G
------
S
A
T
F
D
H
E
H
H
T
T
-
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
-
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
-
Q
T
H
E
-----
N
R
E
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
-
T
R
K
Q
-
K
Y
-
F
--
Y
K
G
-----
G
-
L
--
V
-------------
W
D
E
N
---------------
S
---------------
S
--------------
D
----
G
-
R
-
Y
--
V
--------
K
--
E
N
C
---
K
P
L
--------------
K
------------------
S
-
Y
M
LQD-------
S
-
L
E
H
V
-------------
Q
------------------
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
---
A
G
L
T
P
E
E
R
--------------------------------------------------------------------------------------------------------------
182
Blastp_CBE
60.13
33%
-69
- C1 -
-
5J1V
2
CLK1_HUMAN
C:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
---
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-----------------------------------------------------------------------------------------------------------
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
189
Blastp_CBE
59.80
32%
-42
- C1 -
-
6KHE
1
CLK2_HUMAN
A:
[144-485]
-------------------------------------------------------------------------------------
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
-
H
-
R
R
G
G
A
-
R
-
V
A
L
K
-------
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
-------
N
L
C
V
Q
M
F
D
W
F
D
-------
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
-
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
D
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
N
----
S
D
YELTYNLEKKRDERSVK
S
T
-----------------
A
V
R
V
V
D
F
G
------
S
A
T
F
D
H
E
H
H
S
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
-
Q
T
H
D
-----
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
-
Y
F
-
Y
--
R
G
R
------------------------
L
D
W
D
---------------
E
---------------
N
--------------
T
----
S
-
A
-
G
--
R
--------
Y
----
V
---
R
E
N
--------------
C
------------------
K
-
P
L
----------
R
-
R
Y
L
T
-------------
S
EAEEHHQ-----------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
E
-------------------------------------------------------------------------------------------------------------------
234
HHSearch
59.64
33%
-36
- C1 -
-
6KHD
1
CLK1_HUMAN
A:
[150-480]
---------------------------------------------------------------------------------------------
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
-
A
-
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
YTEERTLI---------
N
P
-----------------
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
--
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
-
Y
F
-
H
--
H
D
R
-----
L
D
W
--
D
-------------
E
H
S
S
---------------
A
---------------
G
--------------
R
Y---
V
-
S
-
R
--
A
--------
C
--
K
P
L
---
K
E
F
--------------
M
------------------
L
-
S
Q
----------
D
-
V
E
H
E
-------------
R
------------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
----------------------------------------------------------------------------------------------------------------------
192
Blastp_CBE
59.37
33%
-50
- C1 -
-
2VAG
1
CLK1_HUMAN
A:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNKRDERTLINP---
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
235
HHSearch
59.21
33%
-33
- C1 -
-
6KHD
1
CLK1_HUMAN
B:
[150-480]
---------------------------------------------------------------------------------------------
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
-
A
-
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
YTEAYNPKRDERTLI--
N
P
-----------------
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
--
Y
-
F
--
H
H
D
-----
R
-
L
DW
D
-------------
E
H
S
S
---------------
A
---------------
G
--------------
R
Y---
V
-
S
-
R
--
A
--------
C
--
K
P
L
---
K
E
F
--------------
M
------------------
L
-
S
Q
----------
D
-
V
E
H
E
-------------
R
------------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
----------------------------------------------------------------------------------------------------------------------
172
Blastp_CBE
58.87
33%
-45
- C1 -
-
6I5H
6
CLK1_HUMAN
A:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
RTLINP-----------
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
161
Blastp_CBE
58.83
33%
-30
- C1 -
-
6Q8P
1
CLK1_HUMAN
C:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKRDERTLINP--
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
-
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
179
Blastp_CBE
58.50
33%
-62
- C1 -
-
5J1W
5
CLK1_HUMAN
C:
[10-329]
--------------------------------------------------------------------------------------------------
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
-----------------
Y
T
EAYNPKIKRDERTLINP
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
------------------------------------------------------------------------------------------------------------
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
58.24
33%
-35
- C1 -
-
6KHD
1
CLK1_HUMAN
B:
[149-474]
--------------------------------------------------------------------------------------------
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
YTEAYNPKRDERTLI--
N
P
-----------------
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
239
HHSearch
58.21
32%
-36
- C1 -
-
6KHE
1
CLK2_HUMAN
A:
[152-483]
---------------------------------------------------------------------------------------------
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
-
R
-
G
G
A
-
R
-
V
A
L
K
-------
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
N
K
-------
N
L
C
V
Q
M
F
D
W
F
D
-------
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
-
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
--
H
D
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
N
----
S
D
YELTYNLEKKRDERSVK
S
T
-----------------
A
V
R
V
V
D
F
G
------
S
A
T
F
D
H
E
H
H
S
T
-
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
-
Q
T
H
D
-----
N
R
E
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
Q
K
-
Y
F
-
Y
--
R
G
R
-----
L
D
W
--
D
-------------
E
N
T
S
---------------
A
---------------
G
--------------
R
Y---
V
-
R
-
E
--
N
--------
C
--
K
P
L
---
R
R
Y
--------------
L
------------------
T
-
S
E
----------
A
-
E
E
H
H
-------------
Q
------------------
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
---------------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
58.01
33%
-30
- C1 -
-
6KHD
1
CLK1_HUMAN
C:
[150-474]
---------------------------------------------------------------------------------------------
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
YTEAYNDERTLI-----
N
P
-----------------
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
57.70
36%
-83
- C1 -
-
6P5S
1
HIPK2_HUMAN
A:
[42-370]
--------------------------------------------------------------------------------------------------------
Y
E
V
L
E
F
L
G
R
---
G
Q
V
V
K
C
W
K
-
R
-
G
-
T
N
E
-
I
-
V
A
I
K
-------
I
L
-------
R
Q
G
Q
I
E
V
S
I
L
A
R
L
S
T
E
S
A
D
D
--------
Y
N
F
V
R
A
Y
E
C
F
Q
-------
H
------
H
T
C
L
V
F
E
M
L
E
Q
N
L
Y
D
F
L
K
Q
N
K
F
S
-
P
L
P
L
K
Y
I
R
P
V
L
Q
Q
V
A
T
A
L
M
K
L
--
K
S
L
-
G
--
L
I
H
A
D
L
K
P
E
N
I
M
--------
L
-----------------------
V
D
----
P
S
-----------------
R
Q
PY---------------
R
V
K
V
I
D
F
G
------
S
A
S
H
V
-----
S
-
T
L
Q
S
R
Y
Y
R
A
P
E
I
I
L
G
-
L
P
F
C
E
A
I
D
M
W
S
L
G
C
V
I
A
E
L
F
L
G
W
P
L
Y
-
P
G
A
S
-----
E
Y
D
Q
I
R
Y
I
S
Q
T
Q
G
L
P
A
E
Y
L
L
S
A
G
T
K
T
T
-
R
F
-
F
NR
D
T
D
-----
P
-
Y
--
P
LWRLKTPDDHEAE
T
G
I
K
---------------
S
---------------
K
--------------
E
----
A
-
R
-
K
--
Y
--------
I
--
F
N
C
L--
D
D
M
--------------
A
------------------
Q
-
V
N
----------
M
-
T
T
D
L
EGSDMLVEKADRR
E
------------------
F
I
D
L
L
K
K
M
L
T
I
D
A
D
K
R
I
T
P
I
E
T
L
N
H
P
F
V
-------------------------------------------------------------------------------------------------------------------------
152
Blastp_CBE
57.34
33%
-40
- C1 -
-
6KHD
1
CLK1_HUMAN
A:
[149-474]
--------------------------------------------------------------------------------------------
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
-
H
-
K
A
G
G
R
-
H
-
V
A
V
K
-------
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
-------
F
R
C
V
Q
M
L
E
W
F
E
-------
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
-
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
S
N
-
K
--
L
T
H
T
D
L
K
P
E
N
I
L
--------
F
-----------------------
V
Q
----
S
D
YTEERTLI---------
N
P
-----------------
D
I
K
V
V
D
F
G
------
S
A
T
Y
D
D
E
H
H
S
T
-
L
V
--
R
H
Y
R
A
P
E
V
I
L
A
-
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
-
P
T
H
D
-----
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
-
K
T
R
K
R
-
K
Y
-
F
--
H
H
D
-----
R
-
L
--
D
-------------
W
D
E
H
---------------
S
---------------
S
--------------
A
----
G
-
R
-
Y
--
V
--------
S
--
R
A
C
---
K
P
L
--------------
K
------------------
E
-
F
M
----------
L
-
S
Q
D
V
-------------
E
HER---------------
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
----------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
55.74
31%
-5
- C1 -
-
1Q8Y
1
?
B:
[20-362]
-------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
---
F
S
T
V
W
L
A
K
D
-
M
-
V
-
N
N
T
-
H
-
V
A
M
K
-------
I
V
R
G
D
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
--
R
V
N
D
A
D
N
T
KEDSMGA
N
H
I
L
K
L
L
D
H
F
N
-------
H
K
G
PNGV
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
Y
E
H
R
-
G
I
P
L
I
Y
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
--
H
R
R
C
G
--
I
I
H
T
D
I
K
P
E
N
V
L
--------
M
EIVD-------------------
S
P
----
E
N
-----------------
L
I
-----------------
Q
I
K
I
A
D
L
G
------
N
A
C
W
Y
D
E
H
Y
T
N
-
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
-
A
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
D
F
L
F
E
P
D
E
G
HSYTK
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
R
N
G
K
Y
T
R
-
T
F
-
F
--
N
S
R
-----
G
-
L
--
L
-------------
R
N
I
S
---------------
K
-------------------------------------
L
-
K
--
F
--------
W
--
P
L
E
---
D
V
L
--------------
T
------------------
E
-
K
Y
----------
K
F
S
K
D
E
-------------
A
KE----------------
I
S
D
F
L
S
P
M
L
Q
L
D
P
R
K
R
A
D
A
G
G
L
V
N
H
P
W
L
K
D
T
L
G
M
E
E
I
R
V
P
D
R
E
L
Y
G
S
G
S
D
I
P
G
------------------------------------------------------------------------------------------------
211
Blastp_CBE
54.70
31%
-13
- C1 -
-
1Q97
1
?
A:
[20-362]
-------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
-
M
-
V
-
N
N
T
-
H
-
V
A
M
K
-------
I
V
R
G
D
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
--
R
V
N
D
A
D
N
T
KEDSMGA
N
H
I
L
K
L
L
D
H
F
N
-------
H
K
G
PNGV
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
Y
E
H
R
-
G
I
P
L
I
Y
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
--
H
R
R
C
G
--
I
I
H
T
D
I
K
P
E
N
V
L
--------
M
EIVD-------------------
S
P
----
E
N
-----------------
L
I
-----------------
Q
I
K
I
A
D
L
G
------
N
A
C
W
Y
D
E
H
Y
T
N
-
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
-
A
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
D
F
L
F
-----K----
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
R
N
G
K
Y
T
R
-
T
F
-
F
--
N
S
--------
L
--
L
-------------
R
N
I
S
---------------
K
-------------------------------------
L
-
K
--
F
--------
W
--
P
L
E
---
D
V
L
--------------
T
------------------
E
-
K
Y
----------
K
F
S
K
D
E
-------------
A
KE----------------
I
S
D
F
L
S
P
M
L
Q
L
D
P
R
K
R
A
D
A
G
G
L
V
N
H
P
W
L
K
D
T
L
G
M
E
E
I
R
V
P
D
R
E
L
Y
G
S
G
S
D
I
P
G
------------------------------------------------------------------------------------------------
208
Blastp_CBE
54.49
31%
-6
- C1 -
-
1Q99
2
SKY1_YEAST
B:
[20-362]
-------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
-
M
-
V
-
N
N
T
-
H
-
V
A
M
K
-------
I
V
R
G
D
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
--
R
V
N
D
A
D
N
T
KEDSMGA
N
H
I
L
K
L
L
D
H
F
N
-------
H
K
G
PNGV
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
Y
E
H
R
-
G
I
P
L
I
Y
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
--
H
R
R
C
G
--
I
I
H
T
D
I
K
P
E
N
V
L
--------
M
EIVD-------------------
S
P
----
E
N
-----------------
L
I
-----------------
Q
I
K
I
A
D
L
G
------
N
A
C
W
Y
D
E
H
Y
T
N
-
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
-
A
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
D
F
L
F
E
P
D
E
G
HSYTK
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
R
N
G
K
Y
T
R
-
T
F
-
F
--
N
S
R
-----
G
-
L
--
L
-------------
R
N
I
S
---------------
K
-------------------------------------
L
-
K
--
F
--------
W
--
P
L
E
---
D
V
L
--------------
T
------------------
E
-
K
Y
----------
K
F
S
K
D
E
-------------
A
KE----------------
I
S
D
F
L
S
P
M
L
Q
L
D
P
R
K
R
A
D
A
G
G
L
V
N
H
P
W
L
K
D
T
L
G
M
E
E
I
R
V
P
D
R
E
L
Y
G
S
G
S
D
I
P
G
------------------------------------------------------------------------------------------------
209
Blastp_CBE
54.29
31%
-22
- C1 -
-
1Q99
2
SKY1_YEAST
A:
[20-362]
-------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
-
M
-
V
-
N
N
T
-
H
-
V
A
M
K
-------
I
V
R
G
D
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
--
R
V
N
D
A
D
N
T
KEDSMGA
N
H
I
L
K
L
L
D
H
F
N
-------
H
K
G
PNGV
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
Y
E
H
R
-
G
I
P
L
I
Y
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
--
H
R
R
C
G
--
I
I
H
T
D
I
K
P
E
N
V
L
--------
M
EIVD-------------------
S
P
----
E
N
-----------------
L
I
-----------------
Q
I
K
I
A
D
L
G
------
N
A
C
W
Y
D
E
H
Y
T
N
-
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
-
A
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
D
F
L
F
E----TK---
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
R
N
G
K
Y
T
R
-
T
F
-
F
--
N
S
--------
L
--
L
-------------
R
N
I
S
---------------
K
-------------------------------------
L
-
K
--
F
--------
W
--
P
L
E
---
D
V
L
--------------
T
------------------
E
-
K
Y
----------
K
F
S
K
D
E
-------------
A
KE----------------
I
S
D
F
L
S
P
M
L
Q
L
D
P
R
K
R
A
D
A
G
G
L
V
N
H
P
W
L
K
D
T
L
G
M
E
E
I
R
V
P
D
R
E
L
Y
G
S
G
S
D
I
P
G
------------------------------------------------------------------------------------------------
215
Blastp_CBE
53.31
31%
-12
- C1 -
-
1Q8Y
1
?
A:
[20-362]
-------------------------------------------------------------------------------------------------------
R
Y
I
L
V
R
K
L
G
W
G
H
F
S
T
V
W
L
A
K
D
-
M
-
V
-
N
N
T
-
H
-
V
A
M
K
-------
I
V
R
G
D
K
V
Y
T
E
A
A
E
D
E
I
K
L
L
Q
--
R
V
N
D
A
D
N
T
KEDSMGA
N
H
I
L
K
L
L
D
H
F
N
-------
H
K
G
PNGV
H
V
V
M
V
F
E
V
L
G
E
N
L
L
A
L
I
K
K
Y
E
H
R
-
G
I
P
L
I
Y
V
K
Q
I
S
K
Q
L
L
L
G
L
D
Y
M
--
H
R
R
C
G
--
I
I
H
T
D
I
K
P
E
N
V
L
--------
M
EIVD-------------------
S
P
----
E
N
-----------------
L
I
-----------------
Q
I
K
I
A
D
L
G
------
N
A
C
W
Y
D
E
H
Y
T
N
-
S
I
Q
T
R
E
Y
R
S
P
E
V
L
L
G
-
A
P
W
G
C
G
A
D
I
W
S
T
A
C
L
I
F
E
L
I
T
G
D
F
L
F
-----K----
D
D
D
H
I
A
Q
I
I
E
L
L
G
E
L
P
S
Y
L
L
R
N
G
K
Y
T
R
-
T
F
-
F
--
N
S
--------
L
--
L
-------------
R
N
I
S
---------------
K
-------------------------------------
L
-
K
--
F
--------
W
--
P
L
E
---
D
V
L
--------------
T
------------------
E
-
K
Y
----------
K
F
S
K
D
E
-------------
A
KE----------------
I
S
D
F
L
S
P
M
L
Q
L
D
P
R
K
R
A
D
A
G
G
L
V
N
H
P
W
L
K
D
T
L
G
M
E
E
I
R
V
P
D
R
E
L
Y
G
S
G
S
D
I
P
G
------------------------------------------------------------------------------------------------
227
Blastp_CBE
49.08
31%
-30
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[8-310]
--------------------------------------------------------------------------------------------------------
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
-
R
-
L
-
T
G
Q
-
Q
-
V
A
I
K
KIPNAFD
V
V
T
N
A
K
R
----
T
L
R
E
L
K
I
L
K
H
F
K
H
D
-------------
N
I
I
A
I
K
D
I
L
R
PTVPYGE
F
K
S
----
V
Y
-
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
--
Q
-
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
--
H
S
A
-
Q
--
V
I
H
R
D
L
K
P
S
N
L
L
--------
V
-----------------------
N
E
----
N
C
-----------------
E
-------------------
L
K
I
G
D
F
G
MARGLC
T
S
P
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
-
P
G
K
N
-----
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
-
V
R
-
A
--
Y
I
Q
-----
S
-
L
--
P
------------------------------------------------------------------------
P
--
R
--------
Q
--
P
V
P
---
W
E
----------------------------------
T
-
V
Y
----------
P
-
G
A
D
R
-------------
Q
------------------
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
---------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
48.57
31%
-17
- C1 -
-
6PK6
1
A:
[14-351]
-------------------------------------------------------------------------------------
W
T
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
-
N
A
R
-
A
N
Q
-
E
-
V
A
V
K
-------
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
-------
F
H
C
L
R
L
F
R
H
F
Y
-------
H
K
Q
----
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
--
K
R
C
-
N
--
I
L
H
A
D
I
K
P
D
N
I
---------
L
-----------------------
V
N
----
E
S
-----------------
K
T
-----------------
I
L
K
L
C
D
F
G
------
S
A
S
H
V
A
D
N
D
I
T
-
P
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
-
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
-
P
G
K
T
-----
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
K
G
V
F
K
D
-
Q
H
-
F
--
D
Q
N
-----
L
-
N
--
F
-------------
M
Y
I
E
---------------
V
---------------
D
--------------
K
----
V
-
T
-
E
--
R
EKVTVMST
I
--
N
P
T
---
K
D
L
--------------
L
------------------
A
-
D
L
IGCQRLPEDQ
R
-
K
K
V
H
-------------
Q
------------------
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
-----------------------------------------------------------------------------------------------------------------------
197
Blastp_CBE
48.13
31%
-21
- C1 -
-
4IIR
1
PRP4B_HUMAN
A:
[13-350]
-------------------------------------------------------------------------------------
W
T
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
--
S
N
V
V
R
A
R
D
-
N
A
R
-
A
N
Q
-
E
-
V
A
V
K
-------
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
-------
F
H
C
L
R
L
F
R
H
F
Y
-------
H
K
Q
----
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
--
K
R
C
-
N
--
I
L
H
A
D
I
K
P
D
N
I
---------
L
-----------------------
V
N
----
E
S
-----------------
K
T
-----------------
I
L
K
L
C
D
F
G
------
S
A
S
H
V
A
D
N
D
I
T
-
P
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
-
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
-
P
G
K
T
-----
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
K
G
V
F
K
D
-
Q
H
-
F
--
D
Q
N
-----
L
-
N
--
F
-------------
M
Y
I
E
----------------------------------------------------------
R
EKVTVMST
I
--
N
P
T
---
K
D
L
--------------
L
------------------
A
-
D
L
IGPEDQ----
R
-
K
K
V
H
-------------
Q
------------------
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
-----------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
47.65
31%
-13
- C1 -
-
4IIR
1
B:
[15-350]
---------------------------------------------------------------------------------------
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
---
S
N
V
V
R
A
R
D
-
N
A
R
-
A
N
Q
-
E
-
V
A
V
K
-------
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
-------
F
H
C
L
R
L
F
R
H
F
Y
-------
H
K
Q
----
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
--
K
R
C
-
N
--
I
L
H
A
D
I
K
P
D
N
I
---------
L
-----------------------
V
N
----
E
S
-----------------
K
T
-----------------
I
L
K
L
C
D
F
G
------
S
A
S
H
V
A
D
N
D
I
T
-
P
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
-
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
-
P
G
K
T
-----
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
K
G
V
F
K
D
-
Q
H
-
F
--
D
Q
N
-----
L
-
N
--
F
-------------
M
Y
I
E
---------------
V
---------------
D
--------------
K
-----------
R
EKVTVMST
I
--
N
P
T
---
K
D
L
--------------
L
------------------
A
-
D
L
IGRLPEDQ--
R
-
K
K
V
H
-------------
Q
------------------
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
-----------------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
46.50
31%
-19
- C1 -
-
4IFC
1
PRP4B_HUMAN
A:
[13-350]
-------------------------------------------------------------------------------------
W
T
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
V
F
S
N
V
V
R
A
R
D
-
N
A
R
-
A
N
Q
-
E
-
V
A
V
K
-------
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
-------
F
H
C
L
R
L
F
R
H
F
Y
-------
H
K
Q
----
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
--
K
R
C
-
N
--
I
L
H
A
D
I
K
P
D
N
I
---------
L
-----------------------
V
N
----
E
S
-----------------
K
T
-----------------
I
L
K
L
C
D
F
G
------
S
A
S
H
V
A
D
N
D
I
T
-
P
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
-
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
-
P
G
K
T
-----
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
K
G
V
F
K
D
-
Q
H
-
F
--
D
Q
N
-----
L
-
N
--
F
-------------
M
Y
I
E
----------------------------------------------------------
R
EKVTVMST
I
--
N
P
T
---
K
D
L
--------------
L
------------------
A
-
D
L
IGPEDQ----
R
-
K
K
V
H
-------------
Q
------------------
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
-----------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
46.46
31%
-8
- C1 -
-
4IFC
1
B:
[15-350]
---------------------------------------------------------------------------------------
D
A
E
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
-
V
F
S
N
V
V
R
A
R
D
-
N
A
R
-
A
N
Q
-
E
-
V
A
V
K
-------
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
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K
-------
F
H
C
L
R
L
F
R
H
F
Y
-------
H
K
Q
----
H
L
C
L
V
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E
P
L
S
M
N
L
R
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L
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K
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G
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A
V
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Y
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L
F
L
A
L
K
L
L
--
K
R
C
-
N
--
I
L
H
A
D
I
K
P
D
N
I
---------
L
-----------------------
V
N
----
E
S
-----------------
K
T
-----------------
I
L
K
L
C
D
F
G
------
S
A
S
H
V
A
D
N
D
I
T
-
P
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
-
K
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Y
D
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W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
-
P
G
K
T
-----
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
K
G
V
F
K
D
-
Q
H
-
F
--
D
Q
N
-----
L
-
N
--
F
-------------
M
Y
I
E
---------------
V
---------------
D
--------------
K
-----------
R
EKVTVMST
I
--
N
P
T
---
K
D
L
--------------
L
------------------
A
-
D
L
IGRLPEDQ--
R
-
K
K
V
H
-------------
Q
------------------
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
-----------------------------------------------------------------------------------------------------------------------