@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : EPHA6_HUMAN: (2020-09-08 )
MGGCEVREFLLQFGFFLPLLTAWPGDCSHVSNNQVVLLDTTTVLGELGWKTYPLNGWDAITEMDEHNRPIHTYQVCNVMEPNQNNWLRTNWISRDAAQKIYVEMKFTLRDCNSIPWVLGTCKETFNLFYMESDESHGIKFKPNQYTKIDTIAADESFTQMDLGDRILKLNTEIREVGPIERKGFYLAFQDIGACIALVSVRVFYKKCPFTVRNLAMFPDTIPRVDSSSLVEVRGSCVKSAEERDTPKLYCGADGDWLVPLGRCICSTGYEEIEGSCHACRPGFYKAFAGNTKCSKCPPHSLTYMEATSVCQCEKGYFRAEKDPPSMACTRPPSAPRNVVFNINETALILEWSPPSDTGGRKDLTYSVICKKCGLDTSQCEDCGGGLRFIPRHTGLINNSVIVLDFVSHVNYTFEIEAMNGVSELSFSPKPFTAITVTTDQDAPSLIGVVRKDWASQNSIALSWQAPAFSNGAILDYEIKYYEKEHEQLTYSSTRSKAPSVIITGLKPATKYVFHIRVRTATGYSGYSQKFEFETGDETSDMAAEQGQILVIATAAVGGFTLLVILTLFFLITGRCQWYIKAKMKSEEKRRNHLQNGHLRFPGIKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTTGGKIPIRWTAPEAIAYRKFSSASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIEEGYRLPAPMGCPASLHQLMLHCWQKERNHRPKFTDIVSFLDKLIRNPSALHTLVEDILVMPESPGEVPEYPLFVTVGDWLDSIKMGQYKNNFVAAGFTTFDLISRMSIDDIRRIGVILIGHQRRIVSSIQTLRLHMMHIQEKGFHV
Atome Classification :
(465 SA)
.........10........20........30........40........50....-.-...60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370..-.-....380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650--.-......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760...-.--------..-.----770.-.-.....780.......790.......800.......810.......820.....-..830..--...--..840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.....-----..950.......960.......970.......980.......990.......1000......1010......1020......1030...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MG
G
C
E
V
R
E
F
L
L
Q
F
G
F
F
L
P
L
L
TAWPGDCSHVSNN
Q
V
V
L
L
D
T
T
T
V
L
G
ELGWKTYPLN-
G
-
W
D
A
I
TEMDEHNRP
I
H
T
Y
Q
V
C
NVMEPNQNN
W
L
R
TNWIS
R
D
A
A
Q
K
I
Y
V
E
M
K
F
T
LRDCNSIP
W
V
L
G
T
C
K
E
T
F
N
L
F
Y
M
ESDESH
G
I
K
FKPNQ
Y
T
K
I
D
T
IAADESFTQMDLG
D
R
I
L
KLNT
E
I
REVGPIERK
G
F
Y
L
A
F
Q
D
I
G
A
C
I
A
L
V
S
V
R
V
F
Y
K
KCPF
T
V
R
N
LAMFPDTIPRVDS
S
S
L
V
E
V
R
G
S
C
V
K
S
A
EERDT
P
K
L
Y
CGADG
D
W
L
V
P
L
G
R
C
I
CST
G
Y
E
E
IEGSCHACRPG
F
Y
K
AFAGNTKCSKCPPHS
L
T
Y
M
E
A
T
S
V
CQCEKGYFRAEKDPPSMACTRPPSAPR
N
V
V
F
NINE
T
A
L
I
L
EWSPPSDTGGRKD
L
T
Y
S
V
I
C
K
KCGL-
D
-
T
S
Q
C
E
DCGGG
L
R
FIPRHTGLINN
S
V
I
V
L
D
F
V
SHV
N
Y
T
F
E
I
E
AMNG
V
S
ELSFSPKP
F
T
A
I
T
V
TTDQD
A
P
S
L
I
G
V
V
R
K
DWASQN
S
I
A
L
S
WQAPAFSN
G
A
I
L
D
Y
E
I
K
Y
Y
E
K
E
H
E
QLTYSSTRSKA
P
S
V
I
I
TGLKPA
T
K
Y
V
F
H
I
R
V
R
T
ATGYSGY
S
Q
K
F
E
FETGDET
S
D
M
AAEQG
Q
I
L
V
I
A
TAAVG
G
F
T
L
L
V
I
L
T
L
F
F
L
ITGR
C
Q
W
Y
I
K
AKMK
S
E
E
K
R
R
N
HLQNG
H
L
RFPG
I
K
T
YIDPDTYEDP
S
L
A
V
H
E
F
A
K
EIDPS
R
I
R
I
E
R
V
IGAG
E
F
G
E
V
CSGRLKT--P-GKREI
P
V
A
I
K
TLKGGH
M
D
R
Q
R
R
D
F
L
R
E
A
S
I
MGQFDHP
N
I
I
R
L
E
G
V
VTKRSFPAI
G
V
E
A
F
C
P
S
F
L
R
A
G
F
L
NSIQAPHPVPGGGSLPPRIPAG
R
P
V
M
I
V
V
E
Y
M
ENG
S
L
D
S
F
L
R
K-H--------DG-
H
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
VNS
N
L
V
C
K
VSDF
G
L
S
R
V
LEDDP-EAAYTTT--G
G
K
--
I
P
I
R
WTAP
E
A
I
A
Y
RKFSSASD
A
W
S
Y
G
I
V
M
W
E
V
M
SYGERP
Y
W
EMSNQ
D
V
I
L
S
IEEGYRLPAPMGC
P
A
S
L
H
Q
L
M
L
H
C
W
Q
K
ERNHRP
K
F
T
D
I
V
S
F
L
D
K
L
IRN
P
S
A
L
H
T
L
V
E
D
I
-----
L
VMPESPGEVPEY
P
L
F
V
T
V
G
D
W
L
D
S
IKMGQYKN
N
F
V
AA
G
F
T
T
F
D
L
I
S
RM
S
I
D
D
I
R
R
I
G
V
I
L
IG
H
Q
R
R
I
V
S
S
I
Q
T
L
R
L
H
M
M
H
I
Q
EKGFHV
24
Blastp_CBE
75.55
72%
-137
- C3 -
-
3DKO
1
A:
[19-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
I
D
P
E
T
Y
E
D
P
N
R
A
V
H
Q
F
A
K
E
L
D
A
S
C
I
K
I
E
R
V
I
G
A
-
E
F
G
E
V
C
S
G
R
L
K
L
--
P
-
G
K
R
D
V
A
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
C
E
A
S
I
M
G
Q
F
D
H
P
N
V
V
H
L
E
G
V
V
T
R
------------------------------------------
G
K
P
V
M
I
V
I
E
F
M
E
N
G
A
L
D
A
F
L
R
K
-
H
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
R
Y
L
A
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-------------------------
P
V
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
A
P
M
D
C
P
A
G
L
H
Q
L
M
L
D
C
W
Q
K
E
R
A
E
R
P
K
F
E
Q
I
V
G
I
L
D
K
M
I
R
N
P
N
S
------------------------------------------------------------------------------------------------------
25
Blastp_CBE
75.45
72%
-133
- C3 -
-
2REI
1
A:
[19-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
I
D
P
E
T
Y
E
D
P
N
R
A
V
H
Q
F
A
K
E
L
D
A
S
C
I
K
I
E
R
V
I
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
--
P
-
G
K
R
D
V
A
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
C
E
A
S
I
M
G
Q
F
D
H
P
N
V
V
H
L
E
G
V
V
T
R
------------------------------------------
G
K
P
V
M
I
V
I
E
F
M
E
N
G
A
L
D
A
F
L
R
K
-
H
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
R
Y
L
A
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
------------------------
P
V
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
A
P
M
D
C
P
A
G
L
H
Q
L
M
L
D
C
W
Q
K
E
R
A
E
R
P
K
F
E
Q
I
V
G
I
L
D
K
M
I
R
N
P
N
S
------------------------------------------------------------------------------------------------------
566
HHSearch
74.15
58%
6
- C5 -
-
4M4R
1
EPHA4_HUMAN
A:
[2-509]
------------------------------
P
A
N
E
V
T
L
L
D
S
R
S
V
Q
G
E
L
G
W
I
A
S
P
L
E
G
G
-
W
E
E
V
S
I
M
D
E
K
N
T
P
I
R
T
Y
Q
V
C
N
V
M
E
P
S
Q
N
N
W
L
R
T
D
W
I
T
R
E
G
A
Q
R
V
Y
I
E
I
K
F
T
L
R
D
C
N
S
L
P
G
V
M
G
T
C
K
E
T
F
N
L
Y
Y
Y
E
S
D
N
D
K
E
R
F
I
R
E
N
Q
F
V
K
I
D
T
I
A
A
D
E
S
F
T
Q
V
D
I
G
D
R
I
M
K
L
N
T
E
I
R
D
V
G
P
L
S
K
K
G
F
Y
L
A
F
Q
D
V
G
A
C
I
A
L
V
S
V
R
V
F
Y
K
K
C
P
L
T
V
R
N
L
A
Q
F
P
D
T
I
T
G
A
D
T
S
S
L
V
E
V
R
G
S
C
V
N
N
S
E
E
K
D
V
P
K
M
Y
C
G
A
D
G
E
W
L
V
P
I
G
N
C
L
C
N
A
G
H
E
E
R
S
G
E
C
Q
A
C
K
I
G
Y
Y
K
A
L
S
T
D
A
T
C
A
K
C
P
P
H
S
Y
S
V
W
E
G
A
T
S
C
T
C
D
R
G
F
F
R
A
D
N
D
A
A
S
M
P
C
T
R
P
P
S
A
P
L
N
L
I
S
N
V
N
E
T
S
V
N
L
E
W
S
S
P
Q
N
T
G
G
R
Q
D
I
S
Y
N
V
V
C
K
K
C
G
A
-
G
D
P
S
K
C
R
P
C
G
S
G
V
H
Y
T
P
Q
Q
N
G
L
K
T
T
K
V
S
I
T
D
L
L
A
H
T
N
Y
T
F
E
I
W
A
V
N
G
V
S
K
Y
N
P
N
P
D
Q
S
V
S
V
T
V
T
T
N
Q
A
A
P
S
S
I
A
L
V
Q
A
K
E
V
T
R
Y
S
V
A
L
A
W
L
E
P
D
R
P
N
G
V
I
L
E
Y
E
V
K
Y
Y
E
K
D
Q
N
E
R
S
Y
R
I
V
R
T
A
A
R
N
T
D
I
K
G
L
N
P
L
T
S
Y
V
F
H
V
R
A
R
T
A
A
G
Y
G
D
F
S
E
P
L
E
V
T
T
N
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
73.94
63%
-133
- C3 -
-
3FXX
1
A:
[30-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
T
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
--
P
-
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
------------------------------------------
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
-
H
--------
D
A
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
------------
G
K
--
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
--
A
ARPSN
L
L
L
D
-------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.84
58%
5
- C5 -
-
4M4R
1
EPHA4_HUMAN
A:
[4-507]
--------------------------------
N
E
V
T
L
L
D
S
R
S
V
Q
G
E
L
G
W
I
A
S
P
L
E
-
G
G
W
E
E
V
S
I
M
D
E
K
N
T
P
I
R
T
Y
Q
V
C
N
V
M
E
P
S
Q
N
N
W
L
R
T
D
W
I
T
R
E
G
A
Q
R
V
Y
I
E
I
K
F
T
L
R
D
C
N
S
L
P
G
V
M
G
T
C
K
E
T
F
N
L
Y
Y
Y
E
S
D
N
D
K
E
R
F
I
R
E
N
Q
F
V
K
I
D
T
I
A
A
D
E
S
F
T
Q
V
D
I
G
D
R
I
M
K
L
N
T
E
I
R
D
V
G
P
L
S
K
K
G
F
Y
L
A
F
Q
D
V
G
A
C
I
A
L
V
S
V
R
V
F
Y
K
K
C
P
L
T
V
R
N
L
A
Q
F
P
D
T
I
T
G
A
D
T
S
S
L
V
E
V
R
G
S
C
V
N
N
S
E
E
K
D
V
P
K
M
Y
C
G
A
D
G
E
W
L
V
P
I
G
N
C
L
C
N
A
G
H
E
E
R
S
G
E
C
Q
A
C
K
I
G
Y
Y
K
A
L
S
T
D
A
T
C
A
K
C
P
P
H
S
Y
S
V
W
E
G
A
T
S
C
T
C
D
R
G
F
F
R
A
D
N
D
A
A
S
M
P
C
T
R
P
P
S
A
P
L
N
L
I
S
N
V
N
E
T
S
V
N
L
E
W
S
S
P
Q
N
T
G
G
R
Q
D
I
S
Y
N
V
V
C
K
K
C
G
A
G
D
-
P
S
K
C
R
P
C
G
S
G
V
H
Y
T
P
Q
Q
N
G
L
K
T
T
K
V
S
I
T
D
L
L
A
H
T
N
Y
T
F
E
I
W
A
V
N
G
V
S
K
Y
N
P
N
P
D
Q
S
V
S
V
T
V
T
T
N
Q
A
A
P
S
S
I
A
L
V
Q
A
K
E
V
T
R
Y
S
V
A
L
A
W
L
E
P
D
R
P
N
G
V
I
L
E
Y
E
V
K
Y
Y
E
K
D
Q
N
E
R
S
Y
R
I
V
R
T
A
A
R
N
T
D
I
K
G
L
N
P
L
T
S
Y
V
F
H
V
R
A
R
T
A
A
G
Y
G
D
F
S
E
P
L
E
V
T
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
73.67
74%
-148
- C3 -
-
2Y6O
1
A:
[4-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
E
F
A
K
E
I
D
A
S
C
I
K
I
E
K
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
K
V
--
P
-
G
K
R
E
I
C
V
A
I
K
T
L
K
A
G
Y
T
D
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
K
-----------
C
-------------------------------
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
R
K
-
N
--------
D
G
-
R
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
-------------------------
I
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
K
L
I
R
N
P
N
S
L
-----------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
73.67
63%
-134
- C3 -
-
3FY2
-
A:
[31-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
T
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
--
P
-
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
------------------------------------------
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
-
H
--------
D
A
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
-------------
G
K
--
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
---ARPSN
L
L
L
D
-------------------------------------------------------------------------------------
26
Blastp_CBE
73.44
65%
-131
- C3 -
-
2QOC
2
A:
[10-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
--
P
-
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
------------------------------------------
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
-
H
--------
D
A
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
--------------
K
--
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
S
A
A
ARPSN
L
L
L
D
Q
S
-----------------------------------------------------------------------------------
22
Blastp_CBE
73.44
59%
6
- C5 -
-
4M4R
1
EPHA4_HUMAN
E:
[4-507]
--------------------------------
N
E
V
T
L
L
D
S
R
S
V
Q
G
E
L
G
W
I
A
S
P
L
E
-
G
G
W
E
E
V
S
I
M
D
E
K
N
T
P
I
R
T
Y
Q
V
C
N
V
M
E
P
S
Q
N
N
W
L
R
T
D
W
I
T
R
E
G
A
Q
R
V
Y
I
E
I
K
F
T
L
R
D
C
N
S
L
P
G
V
M
G
T
C
K
E
T
F
N
L
Y
Y
Y
E
S
D
N
D
K
E
R
F
I
R
E
N
Q
F
V
K
I
D
T
I
A
A
D
E
S
F
T
Q
V
D
I
G
D
R
I
M
K
L
N
T
E
I
R
D
V
G
P
L
S
K
K
G
F
Y
L
A
F
Q
D
V
G
A
C
I
A
L
V
S
V
R
V
F
Y
K
K
C
P
L
T
V
R
N
L
A
Q
F
P
D
T
I
T
G
A
D
T
S
S
L
V
E
V
R
G
S
C
V
N
N
S
E
E
K
D
V
P
K
M
Y
C
G
A
D
G
E
W
L
V
P
I
G
N
C
L
C
N
A
G
H
E
E
R
S
G
E
C
Q
A
C
K
I
G
Y
Y
K
A
L
S
T
D
A
T
C
A
K
C
P
P
H
S
Y
S
V
W
E
G
A
T
S
C
T
C
D
R
G
F
F
R
A
D
N
D
A
A
S
M
P
C
T
R
P
P
S
A
P
L
N
L
I
S
N
V
N
E
T
S
V
N
L
E
W
S
S
P
Q
N
T
G
G
R
Q
D
I
S
Y
N
V
V
C
K
K
C
G
A
G
D
-
P
S
K
C
R
P
C
G
S
G
V
H
Y
T
P
Q
Q
N
G
L
K
T
T
K
V
S
I
T
D
L
L
A
H
T
N
Y
T
F
E
I
W
A
V
N
G
V
S
K
Y
N
P
N
P
D
Q
S
V
S
V
T
V
T
T
N
Q
A
A
P
S
S
I
A
L
V
Q
A
K
E
V
T
R
Y
S
V
A
L
A
W
L
E
P
D
R
P
N
G
V
I
L
E
Y
E
V
K
Y
Y
E
K
D
Q
N
E
R
S
Y
R
I
V
R
T
A
A
R
N
T
D
I
K
G
L
N
P
L
T
S
Y
V
F
H
V
R
A
R
T
A
A
G
Y
G
D
F
S
E
P
L
E
V
T
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
73.41
65%
-137
- C3 -
-
4G2F
1
A:
[23-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
--
P
-
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
------------------------------------------
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
-
H
--------
D
A
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
--------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
---PSN--
L
L
L
--------------------------------------------------------------------------------------
75
Blastp_CBE
73.19
66%
-131
- C3 -
-
6FNK
3
A:
[9-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
F
A
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
--
P
-
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
----------------------
N
S
M
--------------------
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
-------------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
R
------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
73.12
62%
-136
- C3 -
-
2QOK
1
A:
[21-330]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
V
D
P
---------
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
--
P
-
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
------------------------------------------
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
-
H
--------
D
A
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
A
R
V
--------------------
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
---PSN--
L
L
L
D
-------------------------------------------------------------------------------------
16
PsiBlast_PDB
73.00
63%
-131
- C3 -
-
2QOQ
1
A:
[21-332]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
V
D
P
H
--
E
D
P
T
Q
T
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
--
P
-
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
------------------------------------------
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
-
H
--------
D
A
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
---------------------
G
K
--
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
---N----
L
L
L
D
Q
S
-----------------------------------------------------------------------------------
42
Blastp_CBE
72.88
74%
-152
- C3 -
-
2XYU
7
A:
[1-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
E
I
D
A
S
C
I
K
I
E
K
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
K
V
--
P
-
G
K
R
E
I
C
V
A
I
K
T
L
K
A
G
Y
T
D
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
K
-----------
C
-------------------------------
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
R
K
-
N
--------
D
G
-
R
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
-------------------------
I
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
K
L
I
R
N
P
N
S
L
-----------------------------------------------------------------------------------------------------
74
Blastp_CBE
72.83
66%
-135
- C3 -
-
6FNM
1
A:
[13-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
--
P
-
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
----------------------
N
S
M
--------------------
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
-------------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
R
------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
72.81
63%
-129
- C3 -
-
2QO7
4
A:
[21-330]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
V
D
P
H
-------
T
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
--
P
-
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
------------------------------------------
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
-
H
--------
D
A
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
-------------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
S
--PSN--
L
L
L
D
-------------------------------------------------------------------------------------
10
PsiBlast_PDB
72.80
63%
-131
- C3 -
-
2QO2
1
A:
[21-330]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
V
D
P
H
--
E
D
P
T
Q
T
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
--
P
-
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
------------------------------------------
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
-
H
--------
D
A
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
-------------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
---SN---
L
L
L
D
-------------------------------------------------------------------------------------
68
Blastp_CBE
72.75
66%
-127
- C3 -
-
2VWX
1
A:
[11-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
--
P
-
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
----------------------
N
S
M
--------------------
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
N
S
-
S
D
-------
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------------
64
Blastp_CBE
72.72
66%
-128
- C3 -
-
2VX1
1
A:
[11-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
--
P
-
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
----------------------
N
S
M
--------------------
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
N
S
-
S
D
-------
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------------
40
Blastp_CBE
72.72
74%
-143
- C3 -
-
2Y6M
3
A:
[4-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
E
F
A
K
E
I
D
A
S
C
I
K
I
E
K
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
K
V
--
P
-
G
K
R
E
I
C
V
A
I
K
T
L
K
A
G
Y
T
D
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
K
-----------
C
-------------------------------
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
R
K
-
N
--------
D
G
-
R
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
--------------------------
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
K
L
I
R
N
P
N
S
L
-----------------------------------------------------------------------------------------------------
43
Blastp_CBE
72.46
67%
-136
- C3 -
-
1JPA
1
B:
[8-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
F
I
D
P
F
T
F
E
D
P
N
E
A
V
R
E
F
A
K
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
-------
K
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
-------------------------------------------
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
--------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
-
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
----------------------------------------------------------------------------------------------------
66
Blastp_CBE
72.40
66%
-121
- C3 -
-
2VWZ
1
A:
[11-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
--
P
-
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
----------------------
N
S
M
--------------------
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
N
S
-
S
D
-------
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
72.31
63%
-134
- C3 -
-
2QO9
1
A:
[34-330]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
--
P
-
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
------------------------------------------
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
-
H
--------
D
A
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
----------------
K
--
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
---N----
L
L
L
D
-------------------------------------------------------------------------------------
67
Blastp_CBE
72.20
66%
-124
- C3 -
-
2VWY
1
A:
[11-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
--
P
-
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
----------------------
N
S
M
--------------------
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
N
S
-
S
D
-------
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------------
51
Blastp_CBE
72.18
68%
-125
- C3 -
-
5MJA
1
EPHB1_HUMAN
A:
[18-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
A
K
E
I
D
V
S
F
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
Y
K
G
R
L
K
L
--
P
-
G
K
R
E
I
Y
V
A
I
K
T
L
K
A
G
Y
S
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
R
N
I
I
R
L
E
G
V
V
T
K
------------------------------------------
S
R
P
V
M
I
I
T
E
F
M
E
N
G
A
L
D
S
F
L
R
Q
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
S
E
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
Y
L
Q
D
D
T
-
S
D
-------------
P
V
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
A
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
S
R
P
R
F
A
E
I
V
N
T
L
D
K
M
I
R
N
P
A
S
L
K
T
V
--------------------------------------------------------------------------------------------------
61
Blastp_CBE
72.17
66%
-137
- C3 -
-
4BB4
1
A:
[9-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
--
P
-
G
K
K
E
S
C
V
A
I
K
T
L
---
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
----------------------
N
S
M
--------------------
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
----------------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------------
65
Blastp_CBE
72.09
66%
-125
- C3 -
-
2VX0
1
A:
[11-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
--
P
-
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
----------------------
N
S
M
--------------------
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
N
S
-
S
D
--------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------------
27
Blastp_CBE
72.05
65%
-130
- C3 -
-
4TWO
1
A:
[23-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
--
P
-
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
------------------------------------------
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
-
H
--------
D
A
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
--------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
---PSN--
L
L
L
D
Q
S
-----------------------------------------------------------------------------------
30
Blastp_CBE
72.04
65%
-133
- C3 -
-
4P5Q
1
A:
[23-318]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
--
P
-
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
------------------------------------------
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
-
H
--------
D
A
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
---------------------
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
---PSN--
L
L
L
D
-------------------------------------------------------------------------------------
36
Blastp_CBE
71.99
65%
-140
- C3 -
-
3DZQ
1
A:
[23-318]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
--
P
-
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
------------------------------------------
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
-
H
--------
D
A
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
------------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
--
L
K
I
I
T
---N----
L
L
L
D
-------------------------------------------------------------------------------------
29
Blastp_CBE
71.83
65%
-142
- C3 -
-
4P5Z
1
A:
[23-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
--
P
-
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
------------------------------------------
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
-
H
--------
D
A
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
--------------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
---N----
L
L
L
--------------------------------------------------------------------------------------
44
Blastp_CBE
71.76
67%
-134
- C3 -
-
1JPA
1
EPHB2_MOUSE
A:
[8-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
F
I
D
P
F
T
F
E
D
P
N
E
A
V
R
E
F
A
K
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
L
------
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
------------------------------------------
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
--------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
---------------------------------------------------------------------------------------------------
31
Blastp_CBE
71.48
65%
-137
- C3 -
-
4P4C
1
A:
[27-318]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
--
P
-
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
------------------------------------------
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
-
H
--------
D
A
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
--------------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
---PSN--
L
L
L
D
-------------------------------------------------------------------------------------
113
Blastp_CBE
71.28
62%
-130
- C3 -
-
5NK3
2
A:
[7-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
------
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
P
-
E
A
T
Y
T
-----
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
120
Blastp_CBE
71.25
62%
-141
- C3 -
-
5IA3
1
A:
[8-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
------
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
---------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
79
Blastp_CBE
71.04
66%
-136
- C3 -
-
4AW5
1
A:
[8-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
--
P
-
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
----------------------
N
S
M
--------------------
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
------------------------
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------------
121
Blastp_CBE
70.96
62%
-117
- C3 -
-
5IA2
3
A:
[4-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
------
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
P
-
E
A
T
Y
T
T
S
--
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
104
Blastp_CBE
70.89
62%
-129
- C3 -
-
5NKC
2
A:
[7-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-------
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
P
-
E
A
T
Y
-------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
72
Blastp_CBE
70.88
66%
-143
- C3 -
-
2YN8
1
B:
[12-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
--
P
-
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
----------------------
N
S
M
--------------------
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
--------------------------
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------------
60
Blastp_CBE
70.88
67%
-138
- C3 -
-
2HEN
1
EPHB2_MOUSE
A:
[1-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
L
--
P
-
G
K
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
------------------------------------------
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
--------------------------------------------------------------------------------------------------
59
Blastp_CBE
70.77
67%
-136
- C3 -
-
2HEN
1
EPHB2_MOUSE
B:
[1-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
L
--
P
-
G
K
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
------------------------------------------
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
--------------------------------------------------------------------------------------------------
28
Blastp_CBE
70.71
65%
-138
- C3 -
-
4TWN
1
A:
[23-318]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
--
P
-
S
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
------------------------------------------
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
-
H
--------
D
A
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
------------------
K
--
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
---SN---
L
L
L
D
-------------------------------------------------------------------------------------
112
Blastp_CBE
70.69
62%
-126
- C3 -
-
5NK4
2
A:
[7-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--------
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
P
-
E
A
T
Y
T
T
S
--
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
94
Blastp_CBE
70.69
62%
-129
- C3 -
-
6FNH
6
EPHA2_HUMAN
B:
[8-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
--
S
---
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
P
-
E
A
---------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
----------------------------------------------------------------------------------------------------
119
Blastp_CBE
70.68
62%
-128
- C3 -
-
5IA4
1
A:
[11-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
------
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
P
-
E
A
T
Y
T
T
S
--
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------------------------------------------------------------------------------------------------------
124
Blastp_CBE
70.63
62%
-139
- C3 -
-
5IA0
11
EPHA2_HUMAN
B:
[6-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
--
S
---
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
----------------------------------------------------------------------------------------------------
57
Blastp_CBE
70.50
67%
-136
- C3 -
-
2HEN
1
D:
[1-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
L
--
P
-
G
K
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
------------------------------------------
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
--------------------------------------------------------------------------------------------------
76
Blastp_CBE
70.44
66%
-138
- C3 -
-
6FNJ
2
B:
[12-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
--
P
-
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
----------------------
N
S
M
--------------------
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-----------------------
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------------
114
Blastp_CBE
70.42
62%
-123
- C3 -
-
5NK2
2
A:
[4-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-------
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
P
-
E
A
T
Y
------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
132
Blastp_CBE
70.40
62%
-134
- C3 -
-
1MQB
1
B:
[35-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
------
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
----------------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
---------------------------------------------------------------------------------------------------
58
Blastp_CBE
70.33
67%
-132
- C3 -
-
2HEN
1
EPHB2_MOUSE
C:
[1-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
L
--
P
-
G
K
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
------------------------------------------
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
--------------------------------------------------------------------------------------------------
77
Blastp_CBE
70.31
66%
-136
- C3 -
-
6FNJ
1
EPHB4_HUMAN
A:
[12-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
--
P
-
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
----------------------
N
S
M
--------------------
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-----------------------
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------------
117
Blastp_CBE
70.28
62%
-141
- C3 -
-
5NJZ
1
A:
[10-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
-----
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
----------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
83
Blastp_CBE
70.19
62%
-139
- C3 -
-
6Q7D
1
?
A:
[6-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
------
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-----------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
73
Blastp_CBE
70.19
66%
-146
- C3 -
-
2YN8
1
EPHB4_HUMAN
A:
[14-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
--------
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
----------------------
N
S
M
--------------------
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
--------------------------
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------------
71
Blastp_CBE
70.16
66%
-147
- C3 -
-
2VWU
1
A:
[12-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
--
P
-
G
K
K
E
S
C
V
A
I
K
T
L
----
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
----------------------
N
S
M
--------------------
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
-------------------------
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
--------------------------------------------------------------------------------------------------
109
Blastp_CBE
70.12
62%
-124
- C3 -
-
5NK7
1
A:
[10-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-------
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
P
-
E
A
T
Y
------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
85
Blastp_CBE
70.09
62%
-135
- C3 -
-
6Q7B
1
?
A:
[5-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
------
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
------------------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
78
Blastp_CBE
70.08
66%
-135
- C3 -
-
6FNI
1
A:
[12-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
--
P
-
G
K
K
E
S
C
V
A
I
K
T
L
-----
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
----------------------
N
S
M
--------------------
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
--------------------
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
R
------------------------------------------------------------------------------------------------
129
Blastp_CBE
69.99
62%
-143
- C3 -
-
5I9W
3
A:
[11-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--------
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-----------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
96
Blastp_CBE
69.99
62%
-138
- C3 -
-
6FNG
7
A:
[5-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-------
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
--------------------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
98
Blastp_CBE
69.98
62%
-143
- C3 -
-
5NKI
1
A:
[10-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-------
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
84
Blastp_CBE
69.96
62%
-139
- C3 -
-
6Q7C
1
?
A:
[5-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
--
F
G
E
V
Y
K
G
M
L
K
T
------
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
------------------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
86
Blastp_CBE
69.95
62%
-134
- C3 -
-
6HEY
1
A:
[6-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
--
S
----
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
-------------------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
103
Blastp_CBE
69.91
62%
-127
- C3 -
-
5NKD
2
A:
[6-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--------
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
P
-
E
A
T
Y
------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
89
Blastp_CBE
69.91
62%
-138
- C3 -
-
6HEV
1
A:
[6-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-------
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
----------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
69
Blastp_CBE
69.88
66%
-142
- C3 -
-
2VWW
1
A:
[12-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
--
P
-
G
K
K
E
S
C
V
A
I
K
T
L
----
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
----------------------
N
S
M
--------------------
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
-------------------------
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
--------------------------------------------------------------------------------------------------
127
Blastp_CBE
69.84
62%
-124
- C3 -
-
5I9Y
4
A:
[6-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
-----
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
P
-
E
A
T
Y
-----------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
115
Blastp_CBE
69.84
62%
-125
- C3 -
-
5NK1
1
A:
[10-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-------
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
P
-
E
A
T
Y
------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
128
Blastp_CBE
69.78
62%
-123
- C3 -
-
5I9X
5
A:
[10-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
-------
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
P
-
E
A
T
Y
------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
107
Blastp_CBE
69.75
62%
-121
- C3 -
-
5NK9
1
A:
[11-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-------
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
P
-
E
A
T
Y
T
T
----
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
70
Blastp_CBE
69.75
66%
-143
- C3 -
-
2VWV
1
A:
[9-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
--
P
-
G
K
K
E
S
C
V
A
I
K
T
L
----
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
----------------------
N
S
M
--------------------
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
----------------------
K
--
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
----------------------------------------------------------------------------------------------------
126
Blastp_CBE
69.70
62%
-134
- C3 -
-
5I9Z
1
A:
[10-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
--
G
E
V
Y
K
G
M
L
K
T
------
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
80
Blastp_CBE
69.66
62%
-139
- C3 -
-
6Q7G
1
?
A:
[7-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
------
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
110
Blastp_CBE
69.64
62%
-125
- C3 -
-
5NK6
1
A:
[11-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-------
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
P
-
E
A
T
Y
-----
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
125
Blastp_CBE
69.50
62%
-137
- C3 -
-
5IA0
7
EPHA2_HUMAN
A:
[10-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
------
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
82
Blastp_CBE
69.50
62%
-140
- C3 -
-
6Q7E
1
?
A:
[7-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
-------
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
122
Blastp_CBE
69.39
62%
-142
- C3 -
-
5IA1
2
A:
[11-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--------
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
----------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
133
Blastp_CBE
69.26
62%
-136
- C3 -
-
1MQB
1
EPHA2_HUMAN
A:
[38-319]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
-----
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
--------------------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
45
Blastp_CBE
69.25
64%
-131
- C3 -
-
3KUL
2
EPHA8_HUMAN
A:
[43-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
E
I
E
A
S
R
I
H
I
E
K
I
I
G
S
G
D
S
G
E
V
C
Y
G
R
L
R
V
--
P
-
G
Q
R
D
V
P
V
A
I
K
A
L
K
A
G
Y
T
E
R
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
R
------------------------------------------
G
R
L
A
M
I
V
T
E
Y
M
E
N
G
S
L
D
T
F
L
R
T
-
H
--------
D
G
-
Q
----
F
T
I
M
-
Q
-
L
V
G
M
L
R
G
V
G
A
G
M
R
Y
L
S
D
L
G
Y
V
H
R
D
L
A
A
R
N
V
L
V
D
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
-----
A
A
Y
T
T
T
-------
I
P
I
R
W
T
A
P
E
A
I
A
F
R
T
F
S
S
A
S
D
V
W
S
F
G
V
V
M
W
E
V
L
A
Y
G
E
R
P
Y
W
N
M
T
N
R
D
V
I
S
S
V
E
E
G
Y
R
L
P
A
P
M
G
C
P
H
A
L
H
Q
L
M
L
D
C
W
H
K
D
R
A
Q
R
P
R
F
S
Q
I
V
S
V
L
D
A
L
I
R
S
P
E
-------------------------------------------------------------------------------------------------------
93
Blastp_CBE
69.23
62%
-131
- C3 -
-
6FNH
5
C:
[6-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
----
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
56
Blastp_CBE
69.19
66%
-128
- C3 -
-
3ZEW
1
EPHB4_HUMAN
A:
[15-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
--
P
-
G
K
K
E
S
C
V
A
I
K
T
L
----
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
----------------------
N
S
M
--------------------
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
---
S
-
S
D
P
T
T
S
S
---
G
K
--
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------------
55
Blastp_CBE
69.12
66%
-143
- C3 -
-
3ZEW
1
B:
[15-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
-----
K
K
E
S
C
V
A
I
K
T
L
----
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
----------------------
N
S
M
--------------------
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
------------------------
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
--------------------------------------------------------------------------------------------------
105
Blastp_CBE
69.07
62%
-121
- C3 -
-
5NKB
3
A:
[11-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-------
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
P
-
E
A
T
Y
T
T
----
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
92
Blastp_CBE
68.99
62%
-137
- C3 -
-
6HES
2
A:
[5-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-------
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
-----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
90
Blastp_CBE
68.91
62%
-134
- C3 -
-
6HEU
1
A:
[6-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
------
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
-----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
123
Blastp_CBE
68.87
62%
-129
- C3 -
-
5IA0
7
C:
[6-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
----
G
K
K
E
V
P
V
A
I
K
T
L
K
A
--
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
-----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
81
Blastp_CBE
68.82
62%
-132
- C3 -
-
6Q7F
1
?
A:
[11-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
-------
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
88
Blastp_CBE
68.76
62%
-132
- C3 -
-
6HEW
1
A:
[11-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-------
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
------------------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
118
Blastp_CBE
68.69
62%
-123
- C3 -
-
5IA5
3
A:
[11-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
--
S
---
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
P
-
E
A
T
Y
T
T
S
--
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
------------------------------------------------------------------------------------------------------
91
Blastp_CBE
68.46
62%
-138
- C3 -
-
6HET
1
A:
[11-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
-------
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
87
Blastp_CBE
67.98
62%
-136
- C3 -
-
6HEX
1
A:
[11-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-------
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
97
Blastp_CBE
67.93
62%
-132
- C3 -
-
6FNF
1
A:
[12-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
------
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
-----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
63
Blastp_CBE
67.87
66%
-93
- C3 -
-
2X9F
1
A:
[11-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
--
P
-
G
K
K
E
S
C
V
A
I
K
T
L
---
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
----------------------
N
S
M
--------------------
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
-------------L-
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------------
48
Blastp_CBE
67.36
68%
-75
- C3 -
-
5L6P
2
A:
[20-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
Q
--
P
-
G
R
R
E
V
F
V
A
I
K
T
L
K
V
G
Y
T
E
R
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
------------------------------------------
S
R
P
V
M
I
L
T
E
F
M
E
N
C
A
L
D
S
F
L
R
L
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
S
E
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
D
D
P
S
D
P
T
Y
T
S
S
L-
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
V
E
Q
D
Y
R
L
P
P
P
M
D
C
P
T
A
L
H
Q
L
M
L
D
C
W
V
R
D
R
N
L
R
P
K
F
S
Q
I
V
N
T
L
D
K
L
I
R
N
P
A
S
L
K
V
I
--------------------------------------------------------------------------------------------------
49
Blastp_CBE
65.93
68%
-79
- C3 -
-
5L6O
2
A:
[20-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
V
K
I
E
E
V
I
G
A
---
G
E
V
C
R
G
R
L
K
Q
--
P
-
G
R
R
E
V
F
V
A
I
K
T
L
K
V
G
Y
T
E
R
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
------------------------------------------
S
R
P
V
M
I
L
T
E
F
M
E
N
C
A
L
D
S
F
L
R
L
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
S
E
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
----
L
E
D
D
P
S
D
P
T
Y
T
S
S
L-
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
V
E
Q
D
Y
R
L
P
P
P
M
D
C
P
T
A
L
H
Q
L
M
L
D
C
W
V
R
D
R
N
L
R
P
K
F
S
Q
I
V
N
T
L
D
K
L
I
R
N
P
A
S
L
K
V
I
--------------------------------------------------------------------------------------------------
62
Blastp_CBE
65.07
66%
-60
- C3 -
-
2XVD
1
A:
[10-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
--
P
-
G
K
K
E
S
C
V
A
I
K
T
L
---
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
----------------------
N
S
M
--------------------
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
----------
S
SL
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------------
358
Blastp_CBE
63.74
37%
-141
- C3 -
-
2J0J
1
FAK1_CHICK
A:
[373-650]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
D
T
Y
T
M
P
S
T
R
D
Y
E
I
Q
R
E
----
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
F
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
D
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
-----------------------------------------------------------------------------------------------------------
171
Blastp_CBE
63.68
37%
-139
- C3 -
-
4KAB
1
B:
[9-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
-
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
-------------------------------------------------------------------------------------------------------
166
Blastp_CBE
63.62
37%
-143
- C3 -
-
6I8Z
1
A:
[8-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
------------------------------------------------------------------------------------------------------
232
Blastp_CBE
63.56
36%
-144
- C3 -
-
4C7T
1
A:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
F
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
-----------------------------------------------------------------------------------------------------------
184
Blastp_CBE
63.47
37%
-148
- C3 -
-
3PXK
1
FAK1_HUMAN
A:
[9-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
------------------------------------------------------------------------------------------------------
50
Blastp_CBE
63.47
68%
-70
- C3 -
-
5MJA
1
B:
[18-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
A
K
E
I
D
V
S
F
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
Y
K
G
R
L
K
L
--
P
-
G
K
R
E
I
Y
V
A
I
K
T
L
K
A
G
Y
S
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
R
N
I
I
R
L
E
G
V
V
T
K
------------------------------------------
S
R
P
V
M
I
I
T
E
F
M
E
N
G
A
L
D
S
F
L
R
Q
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
S
E
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
Y
L
-------
P
T
T
S
S
L-
G
G
K
--
I
P
V
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
A
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
S
R
P
R
F
A
E
I
V
N
T
L
D
K
M
I
R
N
P
A
S
L
K
T
V
--------------------------------------------------------------------------------------------------
170
Blastp_CBE
63.43
37%
-139
- C3 -
-
2ETM
1
FAK1_HUMAN
A:
[8-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
---------------
K
--
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
------------------------------------------------------------------------------------------------------
173
Blastp_CBE
63.34
37%
-135
- C3 -
-
4K9Y
1
A:
[9-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
D
S
---
T
Y
Y
K
A
S
--
K
G
K
--
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
------------------------------------------------------------------------------------------------------
371
Blastp_CBE
63.13
36%
-143
- C3 -
-
2J0K
1
FAK1_CHICK
B:
[373-650]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
D
T
Y
T
M
P
S
T
R
D
Y
E
I
Q
R
E
----
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
F
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
-----------------------------------------------------------------------------------------------------------
102
Blastp_CBE
63.12
62%
-38
- C3 -
-
5NKE
1
A:
[11-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
--
S
S
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
P
-
E
A
T
Y
T
T
S
--
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
172
Blastp_CBE
63.05
37%
-153
- C3 -
-
4KAB
1
FAK1_HUMAN
A:
[9-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
---
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
-------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
------------------------------------------------------------------------------------------------------
180
Blastp_CBE
63.01
37%
-151
- C3 -
-
4KAO
1
FAK1_HUMAN
A:
[9-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
------
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
------------------------------------------------------------------------------------------------------
228
Blastp_CBE
63.02
36%
-150
- C3 -
-
4D4V
2
FAK1_CHICK
A:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
F
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
---------------------
G
K
--
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
-----------------------------------------------------------------------------------------------------------
176
Blastp_CBE
63.01
37%
-139
- C3 -
-
4GU9
1
B:
[9-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
---
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
--------------------------------------------------------------------------------------------------------
179
Blastp_CBE
62.98
37%
-147
- C3 -
-
4KAO
1
B:
[9-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
---
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
------------------------------------------------------------------------------------------------------
174
Blastp_CBE
62.92
37%
-136
- C3 -
-
4K8A
1
B:
[9-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
-------------------------------------------------------------------------------------------------------
221
Blastp_CBE
62.87
36%
-151
- C3 -
-
4D5H
1
FAK1_CHICK
A:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
F
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
----------------------
K
--
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
-----------------------------------------------------------------------------------------------------------
187
Blastp_CBE
62.87
37%
-144
- C3 -
-
4I4E
1
A:
[11-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
--
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
-------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
------------------------------------------------------------------------------------------------------
177
Blastp_CBE
62.86
37%
-148
- C3 -
-
4GU9
1
FAK1_HUMAN
A:
[9-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
---
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
-------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
------------------------------------------------------------------------------------------------------
233
Blastp_CBE
62.82
36%
-144
- C3 -
-
4BRX
1
FAK1_CHICK
A:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
-
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
F
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
-----------------------------------------------------------------------------------------------------------
222
Blastp_CBE
62.81
36%
-146
- C3 -
-
4D58
1
?
B:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
F
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
-----------------------------------------------------------------------------------------------------------
175
Blastp_CBE
62.80
37%
-144
- C3 -
-
4K8A
1
FAK1_HUMAN
A:
[9-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
---
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
--------------------------------------------------------------------------------------------------------
192
Blastp_CBE
62.76
37%
-159
- C3 -
-
2J0M
1
?
B:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
-----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
-----------------------------------------------------------------------------------------------------------
229
Blastp_CBE
62.74
36%
-146
- C3 -
-
4D4S
1
B:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
F
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
-----------------------------------------------------------------------------------------------------------
99
Blastp_CBE
62.74
62%
-35
- C3 -
-
5NKH
1
A:
[7-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
--
S
S
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
P
-
E
A
T
Y
T
T
S
--
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
234
Blastp_CBE
62.69
36%
-145
- C3 -
-
2JKO
1
A:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
F
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
-----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
-----------------------------------------------------------------------------------------------------------
53
Blastp_CBE
62.62
67%
-68
- C3 -
-
5MJB
1
B:
[17-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
F
A
K
E
I
D
V
S
F
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
Y
K
G
R
L
K
L
--
P
-
G
K
R
E
I
Y
V
A
I
K
T
L
K
A
G
Y
S
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
R
N
I
I
R
L
E
G
V
V
T
K
------------------------------------------
S
R
P
V
M
I
I
T
E
F
M
E
N
C
A
L
D
S
F
L
R
Q
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
S
E
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
Y
L
---
T
-
S
D
P
T
T
S
S
L-
G
G
K
--
I
P
V
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
A
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
S
R
P
R
F
A
E
I
V
N
T
L
D
K
M
I
R
N
P
A
S
L
K
T
V
--------------------------------------------------------------------------------------------------
168
Blastp_CBE
62.55
37%
-141
- C3 -
-
2IJM
1
FAK1_HUMAN
A:
[8-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
------------------------------------------------------------------------------------------------------
101
Blastp_CBE
62.52
62%
-33
- C3 -
-
5NKF
1
A:
[11-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
---S
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
P
-
E
A
T
Y
T
T
S
--
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
193
Blastp_CBE
62.51
37%
-150
- C3 -
-
2JKM
1
A:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
-----------------------------------------------------------------------------------------------------------
95
Blastp_CBE
62.47
62%
-33
- C3 -
-
6FNH
11
EPHA2_HUMAN
A:
[8-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
---S
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
-------------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
186
Blastp_CBE
62.45
37%
-145
- C3 -
-
4I4F
2
A:
[11-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
------
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-------------------
K
--
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
------------------------------------------------------------------------------------------------------
183
Blastp_CBE
62.44
37%
-142
- C3 -
-
3PXK
1
B:
[9-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
-----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
------------------------------------------------------------------------------------------------------
100
Blastp_CBE
62.42
62%
-34
- C3 -
-
5NKG
1
A:
[11-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
--
S
S
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
P
-
E
A
T
Y
T
T
S
--
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
217
Blastp_CBE
62.41
36%
-147
- C3 -
-
6GCX
1
FAK1_CHICK
A:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
M
A
V
A
I
K
T
C
K
N
--
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
F
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
-----------------------------------------------------------------------------------------------------------
167
Blastp_CBE
62.40
37%
-142
- C3 -
-
2IJM
1
B:
[8-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
------------------------------------------------------------------------------------------------------
190
Blastp_CBE
62.38
37%
-143
- C3 -
-
4EBV
3
A:
[34-303]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
--------------------
K
--
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
------------------------------------------------------------------------------------------------------
189
Blastp_CBE
62.36
37%
-145
- C3 -
-
4EBW
1
A:
[34-303]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
-----
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
--------------------
K
--
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
------------------------------------------------------------------------------------------------------
111
Blastp_CBE
62.31
62%
-36
- C3 -
-
5NK5
1
A:
[11-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
---
F
G
E
V
Y
K
G
M
L
K
T
--
S
S
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
P
-
E
A
T
Y
T
T
---
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
169
Blastp_CBE
62.30
37%
-138
- C3 -
-
2ETM
1
B:
[8-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
------------------------------------------------------------------------------------------------------
54
Blastp_CBE
62.23
67%
-66
- C3 -
-
5MJB
1
EPHB1_HUMAN
A:
[17-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
F
A
K
E
I
D
V
S
F
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
Y
K
G
R
L
K
L
--
P
-
G
K
R
E
I
Y
V
A
I
K
T
L
K
A
G
Y
S
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
R
N
I
I
R
L
E
G
V
V
T
K
------------------------------------------
S
R
P
V
M
I
I
T
E
F
M
E
N
C
A
L
D
S
F
L
R
Q
-
N
--------
D
G
-
Q
----
F
T
V
I
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
S
E
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
Y
L
-------
P
T
T
S
S
L-
G
G
K
--
I
P
V
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
A
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
S
R
P
R
F
A
E
I
V
N
T
L
D
K
M
I
R
N
P
A
S
L
K
T
V
--------------------------------------------------------------------------------------------------
181
Blastp_CBE
62.21
37%
-143
- C3 -
-
4GU6
1
B:
[9-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
------------------------------------------------------------------------------------------------------
178
Blastp_CBE
62.19
37%
-141
- C3 -
-
3BZ3
1
A:
[3-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-----
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
------------------------------------------------------------------------------------------------------
235
Blastp_CBE
62.03
36%
-146
- C3 -
-
2JKK
1
?
A:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
F
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
-----------------------------------------------------------------------------------------------------------
227
Blastp_CBE
61.93
36%
-151
- C3 -
-
4D4V
2
B:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
F
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
-----------------------------------------------------------------------------------------------------------
500
Blastp_CBE
61.91
35%
-136
- C3 -
-
4HCT
1
A:
[7-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
-
Y
T
--
S
S
T
--
G
T
K
--
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
491
Blastp_CBE
61.90
35%
-138
- C3 -
-
3T9T
3
A:
[5-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
T
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
-
Y
T
--
S
S
T
--
G
T
K
--
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
61.88
35%
-138
- C3 -
-
4HCV
1
A:
[7-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
-
Y
T
--
S
S
T
--
G
T
K
--
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
499
Blastp_CBE
61.85
35%
-137
- C3 -
-
4HCU
1
A:
[7-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
-
Y
T
--
S
S
T
--
G
T
K
--
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
61.81
62%
-40
- C3 -
-
5I9V
1
A:
[11-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
--
S
S
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
----------------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
191
Blastp_CBE
61.59
37%
-144
- C3 -
-
2JKQ
1
A:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
-----------------------------------------------------------------------------------------------------------
494
Blastp_CBE
61.46
35%
-135
- C3 -
-
4M13
1
A:
[7-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
-
Y
T
--
S
S
T
--
G
T
K
--
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
182
Blastp_CBE
61.44
37%
-129
- C3 -
-
4GU6
1
FAK1_HUMAN
A:
[9-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
-----
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
D
S
---
T
Y
Y
K
A
S
--
K
G
K
--
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
------------------------------------------------------------------------------------------------------
185
Blastp_CBE
61.35
37%
-141
- C3 -
-
4Q9S
1
A:
[11-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
---
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
--------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
------------------------------------------------------------------------------------------------------
188
Blastp_CBE
61.13
37%
-136
- C3 -
-
1MP8
1
A:
[11-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
---
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
Y
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
--------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
------------------------------------------------------------------------------------------------------
492
Blastp_CBE
61.08
35%
-134
- C3 -
-
4M15
2
A:
[7-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
-
Y
T
--
S
S
T
--
G
T
K
--
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
493
Blastp_CBE
61.04
35%
-133
- C3 -
-
4M14
2
A:
[7-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
-
Y
T
--
S
S
T
--
G
T
K
--
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
496
Blastp_CBE
60.88
35%
-133
- C3 -
-
4M0Z
2
A:
[7-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
-
Y
T
--
S
S
T
--
G
T
K
--
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
60.84
62%
-35
- C3 -
-
5NKA
2
A:
[11-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
--
S
S
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
---------------------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
497
Blastp_CBE
60.82
35%
-132
- C3 -
-
4M0Y
2
A:
[7-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
-
Y
T
--
S
S
T
--
G
T
K
--
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
60.77
62%
-43
- C3 -
-
5NK0
1
A:
[8-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
--
S
S
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
490
Blastp_CBE
60.69
35%
-153
- C3 -
-
3V5J
1
ITK_HUMAN
A:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
-
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
--
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
N
S
E
V
V
E
D
I
S
T
G
-
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
495
Blastp_CBE
60.72
35%
-130
- C3 -
-
4M12
1
A:
[7-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
-
Y
T
--
S
S
T
--
G
T
K
--
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
460
Blastp_CBE
60.69
35%
-150
- C3 -
-
4KIO
3
ITK_HUMAN
C:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
60.68
35%
-152
- C3 -
-
4KIO
3
D:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
-----
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
60.64
35%
-141
* C3 *
-
3QGY
1
ITK_HUMAN
A:
[24-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
K
E
G
S
M
S
E
D
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
108
Blastp_CBE
60.54
62%
-41
- C3 -
-
5NK8
1
A:
[11-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
----
G
E
V
Y
K
G
M
L
K
T
--
S
S
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
------------------------------------------
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
--------
D
G
-
E
----
F
S
V
L
-
Q
-
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
------------------------------------------------------------------------------------------------
479
Blastp_CBE
60.37
35%
-148
- C3 -
-
1SM2
1
B:
[2-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
60.33
35%
-147
- C3 -
-
4L7S
1
B:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
60.31
35%
-146
- C3 -
-
4L7S
1
ITK_HUMAN
A:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
60.17
35%
-142
- C3 -
-
1SM2
1
ITK_HUMAN
A:
[2-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
60.07
35%
-152
- C3 -
-
3V5L
1
ITK_HUMAN
C:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
484
Blastp_CBE
60.06
35%
-152
- C3 -
-
3V8T
1
ITK_HUMAN
A:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
------
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
60.05
35%
-142
- C3 -
-
3QGW
1
ITK_HUMAN
A:
[24-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
K
E
G
S
M
S
E
D
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
60.04
35%
-154
- C3 -
-
3V5L
1
D:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
-
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
--
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
487
Blastp_CBE
59.94
35%
-152
- C3 -
-
3V5L
1
ITK_HUMAN
B:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
----
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
----
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
59.84
35%
-153
- C3 -
-
3V8W
1
B:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
---
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
506
Blastp_CBE
59.72
35%
-141
- C3 -
-
3QGW
1
B:
[24-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
K
E
G
S
M
S
E
D
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
59.70
35%
-148
- C3 -
-
4PP9
1
B:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
478
Blastp_CBE
59.69
35%
-139
- C3 -
-
1SNU
1
ITK_HUMAN
A:
[2-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
59.67
35%
-149
- C3 -
-
3V8T
1
B:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
---
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
59.63
35%
-145
- C3 -
-
4PP9
1
ITK_HUMAN
A:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
461
Blastp_CBE
59.53
35%
-160
- C3 -
-
4KIO
2
ITK_HUMAN
B:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
-------
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
551
Fugue
59.37
32%
-88
- C3 -
-
3CD3
3
A:
[1-376]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
I
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
H
S
G
D
F
L
V
R
E
S
Q
E
Y
V
L
S
V
P
R
H
F
I
I
N
L
Y
R
L
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
S
G
V
V
L
H
R
A
V
P
K
D
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
--
D
-
N
T
---
L
V
A
V
K
S
C
R
P
D
L
K
A
K
----
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
------------------------------------------
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
--------
G
A
-
R
----
L
R
V
K
-
T
-
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
-
A
A
S
--
G
G
--
L
R
Q
--
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
--------------------------------------------------------------------------------------------------------
482
Blastp_CBE
59.36
35%
-152
- C3 -
-
3V8W
1
ITK_HUMAN
A:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
-
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
489
Blastp_CBE
59.23
35%
-162
- C3 -
-
3V5J
1
B:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
----
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
59.04
35%
-145
- C3 -
-
1SNU
1
B:
[2-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
473
Blastp_CBE
58.92
35%
-131
- C3 -
-
3MJ2
1
A:
[4-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
-
Y
T
--
S
S
T
--
G
T
K
--
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
------------------------------------------------------------------------------------------------------------------
488
Blastp_CBE
58.78
35%
-147
- C3 -
-
3V5L
1
ITK_HUMAN
A:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
----
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
58.66
35%
-150
- C3 -
-
4KIO
2
ITK_HUMAN
A:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
------
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
58.63
35%
-142
- C3 -
-
4RFM
1
A:
[4-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
---------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
58.56
35%
-132
- C3 -
-
3QGY
1
B:
[24-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
K
E
G
S
M
S
E
D
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
58.29
35%
-148
- C3 -
-
3MIY
1
B:
[4-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
-----
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
57.84
35%
-148
- C3 -
-
3MIY
1
ITK_HUMAN
A:
[4-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
-----
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
57.70
35%
-155
- C3 -
-
4PPA
2
ITK_HUMAN
A:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
-------
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
57.69
35%
-152
- C3 -
-
4QD6
2
B:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
------
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
57.20
35%
-140
- C3 -
-
4MF1
1
B:
[4-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
---
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
---------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
------------------------------------------------------------------------------------------------------------------
456
Blastp_CBE
57.19
35%
-154
- C3 -
-
4MF0
2
ITK_HUMAN
A:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
----
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
57.20
39%
-55
- C3 -
-
2SRC
1
SRC_HUMAN
A:
[178-450]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
T
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
-
Y
T
A
--
R
Q
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
-----------------
P
Q
Q
P
G
E
--------------------------------------------------------------------------------
363
Blastp_CBE
57.19
39%
-49
- C3 -
-
4K11
1
SRC_HUMAN
A:
[176-448]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
T
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
-
Y
T
A
--
R
Q
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
-----------------
P
Q
Q
P
G
E
--------------------------------------------------------------------------------
448
Blastp_CBE
57.13
35%
-159
- C3 -
-
4PPC
2
ITK_HUMAN
A:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
470
Blastp_CBE
57.06
35%
-135
- C3 -
-
4PQN
2
A:
[4-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
------------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
57.02
35%
-147
- C3 -
-
4QD6
2
ITK_HUMAN
A:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
-----
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
56.90
35%
-141
- C3 -
-
4MF1
1
ITK_HUMAN
A:
[4-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
---
A
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
------------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
56.81
35%
-153
- C3 -
-
4MF0
2
B:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
----
M
S
E
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
450
Blastp_CBE
56.53
35%
-150
- C3 -
-
4PPB
2
ITK_HUMAN
A:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
-------
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
545
Blastp_CBE
56.40
34%
-57
- C3 -
-
1OPJ
2
ABL1_MOUSE
B:
[14-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
451
Blastp_CBE
56.31
35%
-153
- C3 -
-
4PPA
2
B:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
-------
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
56.29
39%
-56
- C3 -
-
1KSW
1
SRC_HUMAN
A:
[178-450]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
T
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
-
Y
T
A
--
R
Q
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
-----------------
P
Q
Q
P
G
E
--------------------------------------------------------------------------------
548
Blastp_CBE
56.24
34%
-59
- C3 -
-
1M52
1
ABL1_MOUSE
A:
[14-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
546
Blastp_CBE
56.20
34%
-58
- C3 -
-
1OPJ
2
ABL1_MOUSE
A:
[14-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
533
Blastp_CBE
56.16
34%
-61
- C3 -
-
6HD6
2
ABL1_MOUSE
A:
[14-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
E
--
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
362
Blastp_CBE
56.14
39%
-52
- C3 -
-
6F3F
1
SRC_MOUSE
A:
[181-451]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
-
E
--------
T
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
-
Y
T
A
--
R
Q
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
T
E
-----------------
P
Q
Q
P
G
---------------------------------------------------------------------------------
449
Blastp_CBE
56.10
35%
-149
- C3 -
-
4PPB
2
B:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
-------
E
--
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
525
Blastp_CBE
56.08
34%
-53
- C3 -
-
2QOH
1
ABL1_MOUSE
A:
[9-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
E
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
547
Blastp_CBE
55.94
34%
-58
- C3 -
-
1M52
3
ABL1_MOUSE
B:
[14-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
543
Blastp_CBE
55.90
34%
-60
- C3 -
-
3K5V
2
ABL1_MOUSE
A:
[14-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
E
D
-
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
530
Blastp_CBE
55.78
34%
-56
- C3 -
-
4WA9
1
ABL1_HUMAN
B:
[10-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
N
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
508
Blastp_CBE
55.72
34%
-60
- C3 -
-
4TWP
1
ABL1_HUMAN
B:
[4-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
N
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
512
Blastp_CBE
55.67
34%
-54
- C3 -
-
3IK3
1
ABL1_MOUSE
B:
[9-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
474
Blastp_CBE
55.65
35%
-149
- C3 -
-
3MJ1
1
A:
[4-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
-------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
55.64
34%
-54
- C3 -
-
3OY3
1
ABL1_MOUSE
A:
[9-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
521
Blastp_CBE
55.63
34%
-53
- C3 -
-
3KFA
1
ABL1_MOUSE
A:
[9-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
194
Blastp_CBE
55.61
37%
-86
- C3 -
-
2J0L
1
A:
[6-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
P
-
E
N
P
A
M
A
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-------------------------------------------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
--------
K
F
-
S
----
L
D
L
A
-
S
-
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
D
S
T
-
K
A
----
S
--
K
G
K
--
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
-----------------------------------------------------------------------------------------------------------
447
Blastp_CBE
55.42
35%
-156
- C3 -
-
4PPC
2
B:
[4-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
N
--
K
-
D
K
----
V
A
I
K
T
I
------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
A
------------------------------------------
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--------
R
G
-
L
----
F
A
A
E
-
T
-
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
------------------------------------------------------------------------------------------------------------
524
Blastp_CBE
55.40
34%
-53
- C3 -
-
2QOH
1
ABL1_MOUSE
B:
[9-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
---
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
535
Blastp_CBE
55.39
34%
-59
- C3 -
-
6HD4
3
ABL1_MOUSE
A:
[14-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
E
D
-
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
163
Blastp_CBE
55.35
41%
-72
- C3 -
-
4CSV
1
?
A:
[7-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
N
------
Y
N
I
E
V
A
V
K
T
L
K
E
G
T
M
S
V
E
--
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
------------------------------------------
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
-
C
-----------------
V
N
A
-
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
-----------------------------------------------------------------------------------------------------------
510
Blastp_CBE
55.34
34%
-52
- C3 -
-
3OY3
1
ABL1_MOUSE
B:
[9-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
520
Blastp_CBE
55.31
34%
-54
- C3 -
-
3KFA
1
ABL1_MOUSE
B:
[9-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
514
Blastp_CBE
55.20
34%
-57
- C3 -
-
2Z60
1
ABL1_MOUSE
A:
[9-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
E
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
370
Blastp_CBE
55.08
40%
-50
- C3 -
-
2H8H
1
SRC_HUMAN
A:
[261-519]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
T
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
-
Y
T
A
--
R
Q
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
522
Blastp_CBE
55.03
34%
-51
- C3 -
-
3KF4
1
ABL1_MOUSE
B:
[9-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
---
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
162
Blastp_CBE
54.84
41%
-62
- C3 -
-
4UEU
1
?
A:
[7-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
N
------
Y
N
I
E
V
A
V
K
T
L
K
E
G
T
M
S
V
E
--
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
------------------------------------------
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
-
C
--------
E
G
-
H
----
T
V
N
A
-
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
---------------
A
K
--
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
-----------------------------------------------------------------------------------------------------------
513
Blastp_CBE
54.76
34%
-57
- C3 -
-
3IK3
1
ABL1_MOUSE
A:
[9-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
------
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
516
Blastp_CBE
54.74
34%
-55
- C3 -
-
6BL8
1
ABL1_HUMAN
A:
[4-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
F
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
542
Blastp_CBE
54.65
34%
-58
- C3 -
-
3K5V
2
ABL1_MOUSE
B:
[14-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
---
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
359
Blastp_CBE
54.57
40%
-53
- C3 -
-
1Y57
1
SRC_HUMAN
A:
[178-436]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
T
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
-
Y
T
A
--
R
Q
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
54.54
34%
-55
- C3 -
-
6HD6
1
ABL1_MOUSE
B:
[14-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
---
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
523
Blastp_CBE
54.42
34%
-54
- C3 -
-
3KF4
1
ABL1_MOUSE
A:
[9-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
-----
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
534
Blastp_CBE
54.37
34%
-58
- C3 -
-
6HD4
2
ABL1_MOUSE
B:
[14-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
---
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
526
Blastp_CBE
54.38
35%
-53
- C3 -
-
3QRJ
1
ABL1_HUMAN
B:
[14-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
N
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
-------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
54.37
40%
-53
- C3 -
-
3U4W
4
A:
[1-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
-
Y
T
A
--
R
Q
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
540
Blastp_CBE
54.31
34%
-54
- C3 -
-
3MS9
2
ABL1_MOUSE
B:
[14-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
---
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
----------------------------------------------------------------------------------------------------------
283
Blastp_CBE
54.17
40%
-63
- C3 -
-
3G6G
3
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------
G
A
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
509
Blastp_CBE
54.02
34%
-55
- C3 -
-
4TWP
1
ABL1_HUMAN
A:
[4-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
-----
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
N
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
292
Blastp_CBE
53.95
40%
-57
- C3 -
-
3EN4
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------
A
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
53.92
40%
-68
- C3 -
-
3D7T
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
53.81
40%
-77
- C3 -
-
3F3W
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
53.78
35%
-61
- C3 -
-
3QRJ
1
ABL1_HUMAN
A:
[14-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
-----
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
N
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
-------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
53.76
34%
-64
- C3 -
-
3OXZ
1
ABL1_MOUSE
A:
[9-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-----------
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
318
Blastp_CBE
53.75
40%
-59
- C3 -
-
6HVE
1
?
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
53.73
40%
-64
- C3 -
-
4MXY
1
SRC_HUMAN
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
T
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
53.73
40%
-64
- C3 -
-
4MXZ
1
SRC_HUMAN
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
T
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
53.71
40%
-59
- C3 -
-
3F6X
1
SRC_CHICK
D:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
---------------
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
53.63
40%
-61
- C3 -
-
5XP7
2
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
53.62
40%
-56
- C3 -
-
5XP5
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-------------
G
A
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
53.61
40%
-57
- C3 -
-
3DQX
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-------------
G
A
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
53.58
40%
-56
- C3 -
-
2BDF
1
SRC_HUMAN
B:
[5-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
T
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------
A
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
53.57
40%
-53
- C3 -
-
3DQX
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------
Q
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
53.55
37%
-60
- C3 -
-
3B2W
1
LCK_HUMAN
A:
[14-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
Y
T
A
------
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
269
Blastp_CBE
53.52
40%
-56
- C3 -
-
4U5J
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-------------
G
A
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
53.50
40%
-60
- C3 -
-
4O2P
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
--
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
-----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
544
Blastp_CBE
53.47
34%
-56
- C3 -
-
2HZN
1
ABL1_MOUSE
A:
[14-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
---
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
--
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
344
Blastp_CBE
53.46
40%
-72
- C3 -
-
3F3T
2
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
53.39
40%
-68
- C3 -
-
3G6H
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
53.27
37%
-55
- C3 -
-
1QCF
1
HCK_HUMAN
A:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
-
Y
T
A
--
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
408
Blastp_CBE
53.28
37%
-58
- C3 -
-
2PL0
1
LCK_HUMAN
A:
[19-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
Y
T
A
--
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
340
Blastp_CBE
53.31
40%
-70
- C3 -
-
3F3V
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
281
Blastp_CBE
53.26
40%
-64
- C3 -
-
3UQF
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
53.27
37%
-54
- C3 -
-
5H0E
1
HCK_HUMAN
A:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
-
Y
T
A
--
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
279
Blastp_CBE
53.26
40%
-62
- C3 -
-
3UQG
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
53.23
40%
-63
- C3 -
-
5J5S
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
53.22
40%
-72
- C3 -
-
3F3W
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
53.18
37%
-72
- C3 -
-
3VRY
1
HCK_HUMAN
B:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
285
Blastp_CBE
53.19
40%
-57
- C3 -
-
3F6X
1
SRC_CHICK
C:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
----
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
---------------
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
53.15
37%
-52
- C3 -
-
5H09
1
HCK_HUMAN
A:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
-
Y
T
A
--
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
367
Blastp_CBE
53.18
37%
-60
- C3 -
-
5ZJ6
1
HCK_HUMAN
A:
[20-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
-
Y
T
A
--
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
53.12
34%
-59
- C3 -
-
6BL8
1
ABL1_HUMAN
B:
[4-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
---
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
F
T
A
H
-----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
261
Blastp_CBE
53.16
40%
-65
- C3 -
-
5K9I
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
53.15
40%
-65
- C3 -
-
3EL8
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
53.13
40%
-69
- C3 -
-
5D12
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
-----
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
53.12
40%
-58
- C3 -
-
5XP7
2
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
53.10
40%
-58
- C3 -
-
2BDF
1
SRC_HUMAN
A:
[5-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
T
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
300
Blastp_CBE
53.09
40%
-60
- C3 -
-
2OIQ
3
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------
G
A
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
53.05
37%
-53
- C3 -
-
5H0H
1
HCK_HUMAN
A:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
-
Y
T
A
--
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
52.99
37%
-52
- C3 -
-
5H0G
1
HCK_HUMAN
A:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
-
Y
T
A
--
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
335
Blastp_CBE
52.99
40%
-68
- C3 -
-
3TZ8
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
270
Blastp_CBE
52.98
40%
-64
- C3 -
-
4O2P
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
52.98
40%
-60
- C3 -
-
4YBK
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-----------------
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
52.99
40%
-58
- C3 -
-
4MXO
1
SRC_HUMAN
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
T
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
52.98
40%
-53
- C3 -
-
5XP5
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-------------
G
A
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
434
Blastp_CBE
52.95
37%
-69
- C3 -
-
3VRZ
1
HCK_HUMAN
B:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
52.93
40%
-65
- C3 -
-
1YOM
1
SRC_HUMAN
B:
[9-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
-
E
--------
T
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
536
Blastp_CBE
52.88
34%
-55
- C3 -
-
3MSS
2
ABL1_MOUSE
D:
[14-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
----------------------------------------------------------------------------------------------------------
334
Blastp_CBE
52.86
40%
-65
- C3 -
-
3TZ8
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
52.81
37%
-52
- C3 -
-
5H0B
1
HCK_HUMAN
A:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
-
Y
T
A
--
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
203
Blastp_CBE
52.81
40%
-52
- C3 -
-
2BDJ
1
SRC_HUMAN
A:
[5-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
T
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
341
Blastp_CBE
52.80
40%
-73
- C3 -
-
3F3V
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
52.75
37%
-59
- C3 -
-
5ZJ6
1
HCK_HUMAN
B:
[20-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
-
Y
T
A
--
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
52.72
40%
-62
- C3 -
-
3QLG
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
52.73
37%
-67
- C3 -
-
3VS3
1
HCK_HUMAN
A:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
275
Blastp_CBE
52.72
40%
-62
- C3 -
-
4DGG
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
52.66
40%
-56
- C3 -
-
3SVV
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
C
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
343
Blastp_CBE
52.68
40%
-71
- C3 -
-
3F3U
2
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
52.66
40%
-69
- C3 -
-
3U51
1
SRC_CHICK
A:
[3-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
538
Blastp_CBE
52.61
34%
-57
- C3 -
-
3MSS
2
ABL1_MOUSE
B:
[14-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
----------------------------------------------------------------------------------------------------------
539
Blastp_CBE
52.65
34%
-55
- C3 -
-
3MSS
2
ABL1_MOUSE
A:
[14-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
----------------------------------------------------------------------------------------------------------
314
Blastp_CBE
52.63
40%
-69
- C3 -
-
5T0P
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
C
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
52.61
40%
-62
- C3 -
-
3OEZ
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
52.58
40%
-63
- C3 -
-
3OEZ
2
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
52.60
40%
-64
- C3 -
-
3EN5
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
541
Blastp_CBE
52.54
34%
-57
- C3 -
-
3MS9
2
ABL1_MOUSE
A:
[14-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
----------------------------------------------------------------------------------------------------------
214
Blastp_CBE
52.58
40%
-55
- C3 -
-
4MXO
1
SRC_HUMAN
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
T
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
379
Blastp_CBE
52.54
37%
-55
- C3 -
-
2OF4
1
LCK_HUMAN
A:
[9-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
Y
T
A
--
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
301
Blastp_CBE
52.54
40%
-66
- C3 -
-
3SVV
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
-
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
C
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
52.54
40%
-58
- C3 -
-
4MXY
1
SRC_HUMAN
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
T
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
52.55
40%
-60
- C3 -
-
5K9I
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
237
Blastp_CBE
52.54
40%
-58
- C3 -
-
4MXZ
1
SRC_HUMAN
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
T
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
52.51
37%
-71
- C3 -
-
3VS4
1
HCK_HUMAN
B:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
52.49
37%
-64
- C3 -
-
2C0T
1
HCK_HUMAN
A:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
208
Blastp_CBE
52.47
40%
-60
- C3 -
-
3GEQ
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
--
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
537
Blastp_CBE
52.46
34%
-58
- C3 -
-
3MSS
2
ABL1_MOUSE
C:
[14-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
----------------------------------------------------------------------------------------------------------
337
Blastp_CBE
52.45
40%
-71
- C3 -
-
3TZ7
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
356
Blastp_CBE
52.44
40%
-58
- C3 -
-
5SWH
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
52.43
37%
-53
- C3 -
-
2OF2
1
LCK_HUMAN
A:
[9-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
Y
T
A
--
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
52.39
37%
-50
- C3 -
-
2HK5
1
HCK_HUMAN
A:
[9-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
-
Y
T
A
--
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
52.36
40%
-63
- C3 -
-
5T0P
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
C
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
52.37
40%
-59
- C3 -
-
4MCV
1
SRC_CHICK
A:
[4-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
52.36
40%
-62
- C3 -
-
3EN4
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
--
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
274
Blastp_CBE
52.35
40%
-65
- C3 -
-
4DGG
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
--------
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
432
Blastp_CBE
52.30
37%
-62
- C3 -
-
3VS0
1
HCK_HUMAN
B:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
52.28
37%
-60
- C3 -
-
4LUD
2
HCK_HUMAN
B:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
--
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
52.31
37%
-68
- C3 -
-
3VS1
1
HCK_HUMAN
A:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
52.30
37%
-59
- C3 -
-
3VS3
1
HCK_HUMAN
B:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
---------------
K
--
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
52.28
40%
-69
- C3 -
-
5D11
2
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
-----------
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
435
Blastp_CBE
52.27
37%
-67
- C3 -
-
3VRZ
1
HCK_HUMAN
A:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
52.24
40%
-59
- C3 -
-
5SWH
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
277
Blastp_CBE
52.22
40%
-61
- C3 -
-
4AGW
3
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
52.15
37%
-64
- C3 -
-
2C0T
1
HCK_HUMAN
B:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
336
Blastp_CBE
52.17
40%
-69
- C3 -
-
3TZ7
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
52.16
40%
-57
- C3 -
-
3F6X
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
-
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
52.15
40%
-67
- C3 -
-
3U51
1
B:
[3-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
52.14
37%
-61
- C3 -
-
2C0O
1
HCK_HUMAN
A:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
420
Blastp_CBE
52.11
37%
-68
- C3 -
-
3VS6
1
HCK_HUMAN
B:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
206
Blastp_CBE
52.09
40%
-62
- C3 -
-
4MXX
1
SRC_HUMAN
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
T
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
T
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
52.08
37%
-66
- C3 -
-
3BYU
1
LCK_HUMAN
A:
[15-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
--------------------
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
354
Blastp_CBE
52.03
40%
-63
- C3 -
-
5SYS
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
421
Blastp_CBE
52.05
37%
-69
- C3 -
-
3VS6
1
HCK_HUMAN
A:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
332
Blastp_CBE
52.03
40%
-68
- C3 -
-
3TZ9
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
52.02
37%
-70
- C3 -
-
2OG8
1
LCK_HUMAN
A:
[4-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
52.01
37%
-69
- C3 -
-
3BYS
1
LCK_HUMAN
A:
[15-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
52.00
40%
-59
- C3 -
-
3G6G
2
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
--------------------
G
A
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
51.94
34%
-15
- C3 -
-
4AT3
1
A:
[2-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
LC-----
K
I
L
V
A
V
K
T
L
--
A
S
-
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
------------------------------------------
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
-
H
GPDAVLMA---
N
PPTE
L
T
Q
S
-
Q
-
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
-----
Y
-
S
T
D
Y
Y
R
V
--
G
G
H
TM
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
----------------------------------------------------------------------------------------------------------
276
Blastp_CBE
51.98
40%
-55
- C3 -
-
4AGW
3
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
429
Blastp_CBE
51.97
37%
-63
- C3 -
-
3VS2
1
HCK_HUMAN
A:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
339
Blastp_CBE
51.96
40%
-61
- C3 -
-
3G5D
2
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
-----
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
51.94
40%
-63
- C3 -
-
3QLG
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
-----
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
51.90
37%
-67
- C3 -
-
3VRY
1
HCK_HUMAN
A:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
51.90
37%
-69
- C3 -
-
3VS2
1
HCK_HUMAN
B:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
51.93
40%
-70
- C3 -
-
3TZ9
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
51.92
40%
-59
- C3 -
-
4MCV
1
SRC_CHICK
B:
[4-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
-
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
51.91
40%
-55
- C3 -
-
3UQG
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
----
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
----
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
338
Blastp_CBE
51.90
40%
-61
- C3 -
-
3G5D
2
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
---
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
425
Blastp_CBE
51.85
37%
-63
- C3 -
-
3VS4
1
HCK_HUMAN
A:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
51.84
40%
-63
- C3 -
-
1YOM
1
SRC_HUMAN
A:
[9-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
-
E
--------
T
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
280
Blastp_CBE
51.83
40%
-63
- C3 -
-
3UQF
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
-------
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
51.82
40%
-58
- C3 -
-
3F6X
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
-----
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
---------------
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
51.80
40%
-52
- C3 -
-
3DQW
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
Q
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
467
Blastp_CBE
51.77
36%
-60
- C3 -
-
2ZV8
1
LYN_MOUSE
A:
[6-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
I
K
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
N
--
S
-
T
K
----
V
A
V
K
T
L
K
P
G
T
M
S
V
Q
A
--
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
------------------------------------------
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
G
----
K
V
L
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
----------
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
207
Blastp_CBE
51.75
40%
-54
- C3 -
-
4MXX
1
SRC_HUMAN
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
T
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
T
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
51.70
37%
-59
- C3 -
-
2C0I
1
HCK_HUMAN
A:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
51.70
37%
-63
- C3 -
-
2OG8
1
?
B:
[4-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
-----------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
322
Blastp_CBE
51.67
40%
-69
- C3 -
-
5D11
2
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
--------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
51.63
40%
-59
- C3 -
-
5TEH
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
51.60
34%
-3
- C3 -
-
4AT5
2
A:
[2-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L------
K
I
L
V
A
V
K
T
L
K
D
A
S
-
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
------------------------------------------
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
-
H
GPDAVLMA
E
G
-
N
PPTE
L
T
Q
S
-
Q
-
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
---
D
V
Y
-
S
T
D
Y
Y
R
V
--
G
G
H
TM
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
----------------------------------------------------------------------------------------------------------
353
Blastp_CBE
51.58
40%
-61
- C3 -
-
5SYS
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
51.53
40%
-57
- C3 -
-
5J5S
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
--
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
51.47
37%
-60
- C3 -
-
3VS7
1
HCK_HUMAN
A:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
---------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
305
Blastp_CBE
51.46
40%
-56
- C3 -
-
3QLF
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
--
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
---------------------
A
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
51.43
40%
-63
- C3 -
-
4YBJ
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
51.41
36%
-56
- C3 -
-
2ZV9
1
LYN_MOUSE
A:
[6-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
I
K
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
N
--
S
-
T
K
----
V
A
V
K
T
L
K
P
G
T
M
S
V
Q
A
--
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
------------------------------------------
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
G
----
K
V
L
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
-----------
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
51.40
40%
-68
- C3 -
-
4YBJ
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
-----
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
51.39
40%
-69
- C3 -
-
4FIC
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
----------
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
51.38
36%
-56
- C3 -
-
2ZVA
1
LYN_MOUSE
A:
[6-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
I
K
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
N
--
S
-
T
K
----
V
A
V
K
T
L
K
P
G
T
M
S
V
Q
A
--
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
------------------------------------------
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
G
----
K
V
L
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
E
-----
T
A
--
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
51.36
37%
-69
- C3 -
-
3VS1
1
HCK_HUMAN
B:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
51.35
37%
-63
- C3 -
-
4LUD
1
HCK_HUMAN
A:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
---
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
----
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
51.25
40%
-53
- C3 -
-
3DQW
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
Q
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
51.23
37%
-48
- C3 -
-
3MPM
2
LCK_HUMAN
A:
[5-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
Y
T
A
--
R
--------
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
351
Blastp_CBE
51.22
40%
-63
- C3 -
-
5TEH
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
376
Blastp_CBE
51.21
36%
-65
- C3 -
-
3A4O
1
LYN_HUMAN
X:
[7-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
I
K
L
V
K
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
N
--
S
-
T
K
----
V
A
V
K
T
L
K
P
G
T
M
S
V
Q
A
--
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
R
E
E
------------------------------------------
P
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
G
----
K
V
L
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
------------
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
T
A
L
S
Q
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
51.19
40%
-71
- C3 -
-
3QLF
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
-----------
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
51.17
40%
-48
- C3 -
-
3DQW
1
SRC_CHICK
D:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
Q
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
342
Blastp_CBE
51.14
40%
-61
- C3 -
-
3F3U
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
--
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
51.10
37%
-58
- C3 -
-
3VS5
1
HCK_HUMAN
B:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
373
Blastp_CBE
51.09
36%
-61
- C3 -
-
5XY1
1
LYN_HUMAN
A:
[6-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
I
K
L
V
K
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
N
--
S
-
T
K
----
V
A
V
K
T
L
K
P
G
T
M
S
V
Q
A
--
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
R
E
E
------------------------------------------
P
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
G
----
K
V
L
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
-----------------
K
--
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
T
A
L
S
Q
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
502
Blastp_CBE
51.08
34%
-7
- C3 -
-
4AT4
1
A:
[2-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
LC-----
K
I
L
V
A
V
K
T
L
K
D
A
S
-
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
------------------------------------------
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
-
H
GPDAVLMA----PPTE
L
T
Q
S
-
Q
-
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
---
D
V
Y
-
S
T
D
Y
Y
R
V
--
G
G
H
TM
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
----------------------------------------------------------------------------------------------------------
442
Blastp_CBE
51.07
37%
-54
- C3 -
-
2C0I
1
HCK_HUMAN
B:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
50.96
40%
-49
- C3 -
-
3DQW
1
SRC_CHICK
C:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
Q
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
50.94
37%
-63
- C3 -
-
3VS5
1
HCK_HUMAN
A:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
50.85
40%
-55
- C3 -
-
1YOL
1
SRC_HUMAN
B:
[9-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
-
E
--------
T
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
50.81
40%
-69
- C3 -
-
6HVF
3
?
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
------------
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
50.75
40%
-66
- C3 -
-
2QQ7
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
---------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
317
Blastp_CBE
50.73
40%
-63
- C3 -
-
6HVE
1
?
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
-------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
50.72
40%
-74
- C3 -
-
5D12
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
-------
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
50.71
40%
-54
- C3 -
-
1YOL
1
SRC_HUMAN
A:
[9-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
-
E
--------
T
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
323
Blastp_CBE
50.69
40%
-66
- C3 -
-
5D10
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
---------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
50.68
37%
-59
- C3 -
-
2C0O
1
HCK_HUMAN
B:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
50.67
37%
-48
- C3 -
-
4C3F
1
LCK_HUMAN
A:
[5-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
Y
T
A
--
R
--------
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
50.66
40%
-66
- C3 -
-
2QQ7
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
-------------
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
418
Blastp_CBE
50.63
37%
-59
- C3 -
-
3VS7
1
HCK_HUMAN
B:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
531
Blastp_CBE
50.51
34%
-46
- C3 -
-
4WA9
1
ABL1_HUMAN
A:
[10-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
----------------------
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
---------------------------------------------
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
N
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
Y
T
A
H
A
----
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
212
Blastp_CBE
50.45
40%
-60
- C3 -
-
6ATE
1
SRC_HUMAN
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
------
P
E
--
A
F
--
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
T
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
50.40
40%
-68
- C3 -
-
2QLQ
2
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
---------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
50.39
40%
-60
- C3 -
-
2QLQ
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
----------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
350
Blastp_CBE
50.34
40%
-70
- C3 -
-
2HWO
2
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
-
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
---------
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
---------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
50.32
40%
-65
- C3 -
-
4FIC
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
----------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
433
Blastp_CBE
50.30
37%
-58
- C3 -
-
3VS0
1
HCK_HUMAN
A:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
50.27
40%
-71
- C3 -
-
3LOK
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
---
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
--------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
50.17
37%
-64
- C3 -
-
2OFV
1
?
B:
[14-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
-----
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
-------
I
Q
N
L
E
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
49.84
37%
-60
- C3 -
-
2OFV
1
LCK_HUMAN
A:
[14-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
---------
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
------------------------
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
49.81
40%
-60
- C3 -
-
3EL7
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
-
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
---------------------------------------------
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
49.78
40%
-64
- C3 -
-
6HVF
2
?
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
------------
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
49.67
37%
-63
- C3 -
-
4LUE
3
HCK_HUMAN
B:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
----------
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
---
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
49.56
38%
-43
- C3 -
-
2DQ7
1
X:
[5-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
L
Q
L
I
K
R
L
G
N
G
Q
F
G
E
V
W
M
G
T
W
N
G
--
N
-
T
K
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
S
F
L
E
E
A
Q
I
M
K
K
L
K
H
D
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
D
-
G
--------
E
G
-
R
A---
L
K
L
P
-
N
-
L
V
D
M
A
A
Q
V
A
A
G
M
A
Y
I
E
R
M
N
Y
I
H
R
D
L
R
S
A
N
I
L
V
G
N
G
L
I
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
Q
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
V
T
K
G
R
V
P
Y
P
G
M
N
N
R
E
V
L
E
Q
V
E
R
G
Y
R
M
P
C
P
Q
D
C
P
I
S
L
H
E
L
M
I
H
C
W
K
K
D
P
E
E
R
P
T
F
E
Y
L
Q
S
F
L
E
--------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
49.44
37%
-61
- C3 -
-
4LUE
3
HCK_HUMAN
A:
[182-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
K
--
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
--------
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-------------------------------------------
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
--------
E
G
-
S
----
K
Q
P
L
P
K
-
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
49.35
40%
-59
- C3 -
-
4LGG
1
B:
[4-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
E
V
K
L
G
----
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
---------------------------------------------
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
49.28
40%
-73
- C3 -
-
2HWP
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
--
V
K
L
G
Q
G
C
-
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
------------
F
L
Q
-
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
49.23
40%
-67
- C3 -
-
3LOK
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
-----------------
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
49.23
40%
-58
- C3 -
-
4LGH
1
SRC_CHICK
A:
[3-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
G
----
T
R
----
V
A
I
K
T
L
--------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
49.21
37%
-37
- C3 -
-
1QPD
1
?
A:
[5-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
A
W
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
A
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
----
A
E
T
A
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
349
Blastp_CBE
49.13
40%
-65
- C3 -
-
2HWO
2
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
---------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
407
Blastp_CBE
48.93
37%
-41
- C3 -
-
3KMM
1
LCK_HUMAN
A:
[18-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
48.92
40%
-78
- C3 -
-
2HWP
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
----------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
---------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
399
Blastp_CBE
48.74
37%
-40
- C3 -
-
2ZYB
1
LCK_HUMAN
A:
[15-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
48.64
40%
-73
- C3 -
-
3EN6
1
SRC_CHICK
B:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
--
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
---------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
----------------------------------------------
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
---------------------------
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
48.42
40%
-57
- C3 -
-
4LGH
1
SRC_CHICK
B:
[3-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
-
C
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
48.42
40%
-60
- C3 -
-
3EN7
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
-----
T
R
----
V
A
I
K
T
L
K
P
---------
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
48.38
37%
-39
- C3 -
-
3AD4
3
LCK_HUMAN
A:
[15-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
48.37
37%
-40
- C3 -
-
3AC3
1
LCK_HUMAN
A:
[15-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
382
Blastp_CBE
48.36
37%
-39
- C3 -
-
2OFU
1
LCK_HUMAN
A:
[11-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
48.33
37%
-39
- C3 -
-
3AC2
3
LCK_HUMAN
A:
[15-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
400
Blastp_CBE
48.31
37%
-39
- C3 -
-
2ZM4
2
LCK_HUMAN
A:
[15-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
518
Blastp_CBE
48.22
34%
-43
- C3 -
-
3DK7
1
ABL1_MOUSE
A:
[7-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
K
----
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
T
A
H
---
A
--
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
388
Blastp_CBE
48.21
37%
-38
- C3 -
-
3AD6
2
LCK_HUMAN
A:
[15-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
48.20
37%
-35
- C3 -
-
3BYO
1
?
A:
[9-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
404
Blastp_CBE
48.17
37%
-38
- C3 -
-
1QPC
2
?
A:
[9-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
48.16
37%
-39
- C3 -
-
3ACJ
2
LCK_HUMAN
A:
[15-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
402
Blastp_CBE
48.12
37%
-41
- C3 -
-
1QPJ
1
LCK_HUMAN
A:
[9-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
398
Blastp_CBE
48.02
37%
-38
- C3 -
-
3AC1
3
LCK_HUMAN
A:
[15-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
47.99
37%
-38
- C3 -
-
3AC5
2
LCK_HUMAN
A:
[15-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
405
Blastp_CBE
47.98
37%
-34
- C3 -
-
3KXZ
1
LCK_HUMAN
A:
[17-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
47.94
37%
-49
- C3 -
-
6PDJ
2
?
A:
[18-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
47.92
37%
-37
- C3 -
-
3AC8
1
LCK_HUMAN
A:
[15-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
47.90
40%
-55
- C3 -
-
5D10
1
SRC_CHICK
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
----
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
----
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
401
Blastp_CBE
47.86
37%
-38
- C3 -
-
2ZM1
2
LCK_HUMAN
A:
[15-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
47.84
37%
-35
- C3 -
-
3BYM
1
LCK_HUMAN
A:
[10-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
403
Blastp_CBE
47.81
37%
-36
- C3 -
-
1QPE
1
LCK_HUMAN
A:
[9-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
47.74
37%
-37
- C3 -
-
3ACK
2
LCK_HUMAN
A:
[15-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
529
Blastp_CBE
47.71
34%
-42
- C3 -
-
3DK6
1
ABL1_MOUSE
A:
[7-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
--
G
Q
F
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
-----
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
T
A
H
---
A
--
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
291
Blastp_CBE
47.63
40%
-58
- C3 -
-
3EN5
1
SRC_CHICK
A:
[13-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
----------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-------------------------------------------
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
47.48
37%
-34
- C3 -
-
3AD5
3
LCK_HUMAN
A:
[15-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
395
Blastp_CBE
47.45
37%
-35
- C3 -
-
3AC4
2
LCK_HUMAN
A:
[15-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
--
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-------------------------------------------
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
--------
S
G
I
K
----
L
T
I
N
-
K
-
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
-
T
A
---
R
E
--
G
A
K
--
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
--------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
47.22
40%
-64
- C3 -
-
4LGG
1
SRC_CHICK
A:
[4-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
G
--
T
-
T
R
----
V
A
I
K
T
L
K
P
G
---------
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--------------------------------------------
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
--------
M
G
-
K
----
Y
L
R
L
P
Q
-
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------------
517
Blastp_CBE
47.12
34%
-39
- C3 -
-
3DK7
1
ABL1_MOUSE
B:
[7-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
----
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
T
A
H
---
A
--
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
528
Blastp_CBE
45.86
34%
-37
- C3 -
-
3DK6
1
ABL1_MOUSE
B:
[7-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
-------
E
V
Y
E
G
V
W
K
------
K
Y
S
L
T
V
A
V
K
T
L
-----
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
P
------------------------------------------
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
--------
R
Q
-
E
----
V
S
A
V
-
V
-
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
-
T
A
H
---
A
--
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
--------------------------------------------------------------------
-
* C *
-
-
:
--------------------------------------------------------------------