@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ERBB3_HUMAN: (2020-09-09 )
MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLGGTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEEDNLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQRT
Atome Classification :
(325 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.-...-...700.......710.......720....-..-.-730-.......-----.-740--.......750.......760----.......770......--.-780-.......790.......800...--.....810.......820.......830.......840.......850....-...860......-..870-...----......880.......890.......900.......910.......920....-...930.......940.......950.......960---.......970.......980-.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MRA
N
D
A
L
Q
V
L
G
L
L
F
S
L
ARGSEVGNSQAVCPGTLN
G
L
S
VTGDAE
N
Q
Y
Q
T
L
Y
K
L
Y
E
R
C
E
V
V
MG
N
L
E
I
V
L
TGHNA
D
L
S
F
L
Q
W
I
R
E
VT
G
Y
V
L
V
A
MNEFSTLPLP
N
L
R
V
V
R
G
T
Q
V
YDG
K
F
A
I
F
V
M
L
NYNTN
S
S
H
A
L
R
Q
L
R
L
T
Q
L
T
E
I
LSG
G
V
Y
I
EKNDKLCHMDTI
D
W
R
D
I
VRDRD
A
E
I
V
V
KDNGRSCP
P
C
H
E
V
CKGRCWGPG
S
E
D
C
Q
T
L
T
K
T
ICAPQCNGHCFGPNP
N
Q
C
C
H
D
ECAGGCSGPQDT
D
C
F
A
C
RHFNDSGACVPRCPQP
L
V
Y
N
K
L
T
F
Q
LEPNPHT
K
Y
Q
YG
G
V
C
V
ASCPH
N
F
V
VDQTSCVRACPPDKMEVDKNG
L
K
MCEPCGGLC
P
K
ACEGTGSGS
R
F
Q
TVDSSNI
D
G
F
V
N
C
T
K
I
LG
N
L
D
F
L
I
TGLNGDPWHKIPAL
D
P
E
K
L
N
V
F
R
T
V
R
E
I
T
G
Y
L
NIQSWPPHMHN
F
S
V
F
SN
L
T
TIGG
R
S
L
Y
NRG
F
S
L
L
I
M
KNLNV
T
S
L
G
F
R
S
L
K
E
ISA
G
R
I
Y
I
SAN
R
Q
L
C
Y
HHSL
N
W
T
K
VLRGP
T
E
E
RLDIKHNRP
R
R
D
C
VAEGKVCDPLCSSGGCWGPGPG
Q
C
LSCRNYSRG
G
V
C
V
T
H
CNFLNG
E
P
R
E
F
A
HEA
E
C
FSCHPECQPMEG
T
A
TCNGSGS
D
T
C
A
Q
C
A
HFRDGP
H
C
V
S
SCPHGVLGAKGPIYKYPD
V
Q
N
EC
R
P
C
H
E
N
C
TQGCKGP
E
L
Q
D
C
L
G
Q
T
L
V
L
IGK
T
H
L
T
M
A
L
T
V
I
A
G
L
V
V
I
F
M
M
LGG
T
F
L
Y
WRGRRIQ
N
K
R
A
M
R
R
Y
L
E
RGESIEPLD
P
S
-
E
K
A
-
N
K
V
L
A
R
I
F
K
E
T
E
L
R
K
L
K
VLGSGV
F
G
TVHK
G
-
V
W-I-P-E-G
E
S
I
K
I
P
-----
V
-
C
I
K
--
V
IEDKSGR
Q
S
F
Q
A
V
T
D
H
M
L
A
----IGSL
D
H
A
H
I
V
R
L
L
GLC--P-G
S
S
-
L
Q
L
V
T
Q
YL
P
L
G
S
L
L
D
H
V
R
Q
-
H
RG--AL
G
P
Q
L
L
L
N
WG
V
Q
I
A
K
G
M
Y
Y
L
E
EH
G
M
V
H
R
N
L
A
ARNVLLKSPS
Q
V
Q
V
A
DFG
V
A
-DLLPP-D
D
K
Q
L
L
-
Y
S
E---AKT----
P
I
K
W
M
A
L
E
SIHFGKYTHQS
D
V
W
S
Y
G
V
T
V
W
E
L
M
TFGAEPYAGL
R
L
A
E
V
P
D
L
L
E
K
-
G
E
R
LAQP
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
MIDENI
R
P
T
F
K
E
L
A
---
N
E
F
T
R
MARDPP
R
Y
L
V
I
KRES-GPGIAPGPEPHGLTNK
K
L
E
EVELEPELDL
D
L
DLEAEEDNL
A
T
T
TLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLG
E
S
C
Q
E
S
AVSGSSERCPRPVSLHPMPRGCLASESSEGHVTG
S
E
A
E
L
Q
E
K
V
S
M
C
R
S
RSRSRSPRPRGDS
A
Y
H
S
Q
R
H
SLLTPVTPLSPPGLEEEDVN
G
Y
VMPDTHLKGTPSSREG
T
L
S
S
V
G
L
S
S
VLGTEEEDE
D
E
E
Y
E
Y
M
N
R
RRRHSPPHPPRP
S
S
L
E
E
L
G
Y
E
Y
M
DVGS
D
L
S
A
SLGSTQSCPLHPVPIMPTAGTTP
D
E
D
Y
E
Y
M
NRQRDGGGPGGD
Y
A
AMGACPASEQ
G
Y
E
E
M
R
A
FQGPGHQAP
H
V
H
Y
A
R
L
K
T
L
R
S
LEATDSAFDN
P
D
Y
W
H
SRLFPKANAQRT
15
PsiBlast_PDB
56.25
99%
-151
- C5 -
-
3KEX
1
ERBB3_HUMAN
A:
[4-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
A
R
I
F
K
E
T
E
L
R
K
L
K
V
L
G
S
G
V
F
G
T
V
H
K
G
-
V
W
-
I
-
P
-
E
-
G
E
S
I
K
I
P
-----
V
-
C
I
K
--
V
I
E
D
K
S
G
R
Q
S
F
Q
A
V
T
D
H
M
L
A
----
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
--
P
-
G
S
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
R
G
--
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
-
D
L
L
P
P
-
D
D
K
Q
L
L
---------
T
----
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
-
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
---
N
E
F
T
R
M
A
R
D
P
P
R
Y
L
V
I
K
R
E
S
-
G
P
G
I
A
P
G
P
E
P
H
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
55.51
99%
-149
- C5 -
-
4RIX
1
C:
[5-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
R
I
F
K
E
T
E
L
R
K
L
K
V
L
G
S
G
V
F
G
T
V
H
K
G
-
V
W
-
I
-
P
-
E
-
G
E
S
I
K
I
P
-----
V
-
C
I
K
--
V
I
E
------
S
F
Q
A
V
T
D
H
M
L
A
----
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
--
P
-
G
S
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
R
G
--
A
L
G
P
R
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
-
D
L
L
P
P
-
D
D
K
Q
L
L
-
Y
S
E
---
A
K
T
----
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
-
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
---
N
E
F
T
R
M
A
R
D
P
P
R
Y
L
V
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
55.28
99%
-147
- C5 -
-
3KEX
1
B:
[4-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
A
R
I
F
K
E
T
E
L
R
K
L
K
V
L
G
S
G
V
F
G
T
V
H
K
G
-
V
W
-
I
-
P
-
E
-
G
E
S
I
K
I
P
-----
V
-
C
I
K
--
V
I
E
D
K
S
G
R
Q
S
F
Q
A
V
T
D
H
M
L
A
----
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
--
P
-
G
S
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
R
G
--
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
-
D
L
L
P
P
-
D
D
K
Q
-----------
T
----
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
-
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
---
N
E
F
T
R
M
A
R
D
P
P
R
Y
L
V
I
K
R
E
--
G
P
G
I
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
55.15
100%
-144
- C5 -
-
6OP9
1
A:
[26-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
R
I
F
K
E
T
E
L
R
K
L
K
V
L
G
S
G
V
F
G
T
V
H
K
G
-
V
W
-
I
-
P
-
E
-
G
E
S
I
K
I
P
-----
V
-
C
I
K
--
V
I
E
D
K
S
G
R
Q
S
F
Q
A
V
T
D
H
M
L
A
----
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
--
P
-
G
S
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
R
G
--
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
-
D
L
L
P
P
-
D
D
K
Q
---------
A
K
T
----
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
-
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
---
N
E
F
T
R
M
A
R
D
P
P
R
Y
L
V
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
54.82
99%
-148
- C5 -
-
4RIW
1
C:
[5-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
R
I
F
K
E
T
E
L
R
K
L
K
V
L
G
S
G
V
F
G
T
V
H
K
G
-
V
W
-
I
-
P
-
E
-
G
E
S
I
K
I
P
-----
V
-
C
I
K
--
V
I
E
------
S
F
Q
A
V
T
D
H
M
L
A
----
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
--
P
-
G
S
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
R
G
--
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
-
D
L
L
P
P
-
D
D
K
Q
L
L
-
Y
S
E
---
A
K
T
----
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
-
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
---
N
E
F
T
R
M
A
R
D
P
P
R
Y
L
V
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
54.80
99%
-152
- C5 -
-
4RIY
1
C:
[5-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
R
I
F
K
E
T
E
L
R
K
L
K
V
L
G
S
G
V
F
G
T
V
H
K
G
-
V
W
-
I
-
P
-
E
-
G
E
S
I
K
I
P
-----
V
-
C
I
K
--
V
I
E
------
S
F
Q
A
V
T
D
H
M
L
A
----
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
--
P
-
G
S
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
R
G
--
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
-
D
L
L
P
P
-
D
D
K
Q
L
L
-
Y
S
E
---
A
K
T
----
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
-
G
G
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
---
N
E
F
T
R
M
A
R
D
P
P
R
Y
L
V
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
54.58
98%
-149
- C5 -
-
3LMG
1
ERBB3_HUMAN
A:
[23-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
R
I
F
K
E
T
E
L
R
K
L
K
V
L
G
S
G
V
F
G
T
V
H
K
G
-
V
W
-
I
-
P
-
E
-
G
E
S
I
K
I
P
-----
V
-
C
I
K
--
V
I
E
D
K
---
Q
S
F
Q
A
V
T
D
H
M
L
A
----
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
--
P
-
G
S
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
R
G
--
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
-
D
L
L
P
P
-
D
D
-------------
T
----
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
-
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
---
N
E
F
T
R
M
A
R
D
P
P
R
Y
L
V
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
54.48
99%
-155
- C5 -
-
4RIY
1
ERBB3_HUMAN
A:
[5-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
R
I
F
K
E
T
E
L
R
K
L
K
V
L
G
S
G
V
F
G
T
V
H
K
G
-
V
W
-
I
-
P
-
E
-
G
E
S
I
K
I
P
-----
V
-
C
I
K
--
V
I
E
D
K
S
G
R
Q
S
F
Q
A
V
T
D
H
M
L
A
----
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
--
P
-
G
S
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
R
G
--
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
-
D
L
L
P
P
---------------------
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
-
G
G
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
---
N
E
F
T
R
M
A
R
D
P
P
R
Y
L
V
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
54.46
99%
-149
- C5 -
-
4RIX
1
ERBB3_HUMAN
A:
[5-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
R
I
F
K
E
T
E
L
R
K
L
K
V
L
G
S
G
V
F
G
T
V
H
K
G
-
V
W
-
I
-
P
-
E
-
G
E
S
I
K
I
P
-----
V
-
C
I
K
--
V
I
E
D
K
S
G
R
Q
S
F
Q
A
V
T
D
H
M
L
A
----
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
--
P
-
G
S
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
R
G
--
A
L
G
P
R
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
-
D
L
L
P
P
---------------------
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
-
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
---
N
E
F
T
R
M
A
R
D
P
P
R
Y
L
V
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
54.27
98%
-152
- C5 -
-
3LMG
1
B:
[23-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
R
I
F
K
E
T
E
L
R
K
L
K
V
L
G
S
G
V
F
G
T
V
H
K
G
-
V
W
-
I
-
P
---
G
E
S
I
K
I
P
-----
V
-
C
I
K
--
V
I
E
D
K
S
--
Q
S
F
Q
A
V
T
D
H
M
L
A
----
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
--
P
-
G
S
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
R
G
--
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
-
D
L
L
P
P
-
D
D
K
-----------------
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
-
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
---
N
E
F
T
R
M
A
R
D
P
P
R
Y
L
V
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
54.10
99%
-151
- C5 -
-
4RIW
1
ERBB3_HUMAN
A:
[5-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
R
I
F
K
E
T
E
L
R
K
L
K
V
L
G
S
G
V
F
G
T
V
H
K
G
-
V
W
-
I
-
P
-
E
-
G
E
S
I
K
I
P
-----
V
-
C
I
K
--
V
I
E
D
K
S
G
R
Q
S
F
Q
A
V
T
D
H
M
L
A
----
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
--
P
-
G
S
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
R
G
--
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
-
D
L
L
P
P
---------------------
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
-
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
---
N
E
F
T
R
M
A
R
D
P
P
R
Y
L
V
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
52.25
61%
-128
- C5 -
-
3PP0
1
B:
[7-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
I
W
-
I
-
P
-
D
-
G
E
N
V
K
I
P
-----
V
-
A
I
K
--
V
L
R
E
N
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
-
N
R
G
--
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
-
R
L
L
D
I
-
D
E
T
E
Y
H
-
A
-----
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
---
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
L
G
P
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
51.51
59%
-151
- C5 -
-
3BBT
1
ERBB4_HUMAN
B:
[7-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
L
R
I
L
K
E
T
E
L
K
R
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
I
W
-
V
-
P
-
E
-
G
E
T
V
K
I
P
-----
V
-
A
I
K
--
I
L
N
E
--
G
P
K
A
N
V
E
F
M
D
E
A
L
I
----
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
--
L
-
S
P
T
-
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
-
H
K
D
--
N
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
-
R
L
L
-----------------------
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
R
E
I
P
D
L
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
---
A
E
F
S
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
-
D
D
-
R
M
K
L
-
P
S
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
51.43
61%
-133
- C5 -
-
3PP0
1
ERBB2_HUMAN
A:
[7-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
I
W
-
I
-
P
-
D
-
G
E
N
V
K
I
P
-----
V
-
A
I
K
--
V
L
R
E
N
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
-
N
R
G
--
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
-
R
L
L
D
I
-
D
E
T
E
Y
H
-
A
-----
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
---
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
51.31
59%
-151
- C5 -
-
4ZSE
2
EGFR_HUMAN
A:
[8-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
-----------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
Blastp_CBE
51.30
59%
-139
- C5 -
-
3W32
1
A:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
G
A
-
E
E
K
E
Y
H
-
A
E
G
---
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
51.29
59%
-141
- C5 -
-
5U8L
2
A:
[9-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
L
G
A
-
E
E
K
E
Y
H
-
A
E
G
---
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
51.24
59%
-148
- C5 -
-
5YU9
1
D:
[9-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
51.12
59%
-144
- C5 -
-
5UG9
5
A:
[9-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
----
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
L
G
A
-
E
E
K
E
Y
H
-
A
E
G
---
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
51.11
59%
-136
- C5 -
-
5HG5
2
A:
[7-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
L
G
A
-
E
E
K
E
Y
H
-
A
E
G
---
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
51.09
59%
-136
- C5 -
-
5HG8
2
A:
[7-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
L
G
A
-
E
E
K
E
Y
H
-
A
E
G
---
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
51.01
59%
-144
- C5 -
-
5UGC
5
A:
[9-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
----
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
L
G
A
-
E
E
K
E
Y
H
-
A
E
G
---
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
50.95
59%
-153
- C5 -
-
5CAQ
1
A:
[4-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
-------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
50.94
59%
-143
- C5 -
-
5HIB
1
A:
[4-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
L
------
E
Y
H
-
A
E
G
---
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
50.94
59%
-143
- C5 -
-
5GNK
15
A:
[6-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
G
-----------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
50.90
59%
-152
- C5 -
-
5YU9
1
EGFR_HUMAN
C:
[6-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
----
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
-----------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
50.88
59%
-154
- C5 -
-
4I22
1
A:
[7-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
-----
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
L
------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
50.85
59%
-156
- C5 -
-
3W2S
1
A:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
-----------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
209
Blastp_CBE
50.83
59%
-150
- C5 -
-
4ZSE
2
EGFR_HUMAN
C:
[9-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
50.81
59%
-154
- C5 -
-
5CAN
1
A:
[4-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
-------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
50.75
59%
-151
- C5 -
-
5CAP
1
A:
[4-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
---------------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
50.75
59%
-144
- C5 -
-
4ZSE
1
EGFR_HUMAN
B:
[7-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
-----------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
50.73
59%
-148
- C5 -
-
5X2K
1
A:
[2-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
G
A
-
E
-------
E
G
---
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
50.65
59%
-138
- C5 -
-
5UGA
4
A:
[10-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
L
G
A
-
E
E
K
E
Y
H
-
A
E
G
---
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
182
Blastp_CBE
50.65
59%
-137
- C5 -
-
4HJO
1
A:
[18-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
------
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
G
A
-
E
E
K
E
Y
H
-
A
E
G
---
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
164
Blastp_CBE
50.64
59%
-156
- C5 -
-
5YU9
2
EGFR_HUMAN
B:
[8-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
-----
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
50.62
59%
-139
- C5 -
-
5HG9
4
A:
[9-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
----
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
L
G
A
-
E
E
K
E
Y
H
-
A
E
G
---
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
50.58
59%
-137
- C5 -
-
5X2F
1
D:
[6-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
G
A
-
E
E
K
-----------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
50.54
59%
-141
- C5 -
-
2J5F
1
A:
[2-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
G
A
-
E
E
------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
50.52
59%
-155
- C5 -
-
5CAU
1
A:
[4-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
----
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
-------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
50.50
59%
-153
- C5 -
-
5C8K
1
A:
[4-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
---------------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
270
Blastp_CBE
50.48
59%
-152
- C5 -
-
5C8M
1
A:
[4-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
-------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
50.47
59%
-156
- C5 -
-
4RJ8
1
A:
[4-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
----
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
-------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
50.47
59%
-152
- C5 -
-
5HCZ
1
A:
[4-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
---
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
-------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
50.47
59%
-140
- C5 -
-
5HG7
1
A:
[9-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
---
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
L
G
A
-
E
E
K
E
Y
H
-
A
E
G
---
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
50.45
59%
-150
- C5 -
-
5HIC
1
A:
[4-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
-------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
157
Blastp_CBE
50.39
59%
-154
- C5 -
-
3GT8
1
EGFR_HUMAN
C:
[7-290]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
155
Blastp_CBE
50.38
59%
-151
- C5 -
-
5CNO
1
EGFR_HUMAN
A:
[8-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
-----
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
----------------
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
50.36
59%
-155
- C5 -
-
5HCX
1
A:
[4-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
---
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
-------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
50.35
59%
-149
- C5 -
-
6S9D
2
?
A:
[4-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
--
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
L
----------------
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
197
Blastp_CBE
50.35
59%
-148
- C5 -
-
5X2F
1
EGFR_HUMAN
C:
[9-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
208
Blastp_CBE
50.34
59%
-147
- C5 -
-
4ZSE
1
D:
[10-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
G
-----------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
50.34
60%
-149
- C5 -
-
2RGP
1
A:
[2-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
------
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
-----
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
G
A
-
E
E
------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
50.32
59%
-154
- C5 -
-
5CAS
1
A:
[4-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
----
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
L
------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
50.30
59%
-144
- C5 -
-
5CNN
1
B:
[8-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
Q
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
----------------
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
50.29
59%
-149
- C5 -
-
5X2F
1
EGFR_HUMAN
A:
[9-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
-----------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
50.25
59%
-149
- C5 -
-
4I24
1
B:
[7-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
----------------
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
50.24
59%
-151
- C5 -
-
5X2C
6
EGFR_HUMAN
A:
[9-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
-----------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
50.23
59%
-154
- C5 -
-
3W33
1
A:
[9-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
-----
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
-----------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
50.20
59%
-157
- C5 -
-
5EM6
1
A:
[4-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
---
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
-------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
50.18
59%
-139
- C5 -
-
5JEB
1
A:
[14-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
--
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
G
A
-
E
E
K
E
Y
H
-
A
E
G
---
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
50.17
59%
-152
- C5 -
-
5HCY
1
A:
[4-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
L
------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
50.16
59%
-150
- C5 -
-
5YU9
1
EGFR_HUMAN
A:
[9-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
----
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
-----------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
50.14
59%
-150
- C5 -
-
5CNO
1
EGFR_HUMAN
B:
[6-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
----
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
-----------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
50.13
59%
-154
- C5 -
-
4RJ7
1
A:
[4-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
-----
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
-------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
50.12
59%
-158
- C5 -
-
5EDR
1
A:
[4-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
----------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
50.12
59%
-152
- C5 -
-
5EM7
1
A:
[4-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
-----
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
-------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
206
Blastp_CBE
50.11
59%
-149
- C5 -
-
5D41
1
B:
[10-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
-----------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
50.08
59%
-135
- C5 -
-
5X2F
1
EGFR_HUMAN
B:
[8-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
G
A
-
E
E
K
E
Y
H
-
A
E
G
---
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
50.05
59%
-151
- C5 -
-
5EDQ
1
A:
[4-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
----------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
274
Blastp_CBE
50.03
59%
-153
- C5 -
-
4RJ6
1
A:
[4-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
----
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
-------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
268
Blastp_CBE
49.97
59%
-153
- C5 -
-
5CAL
1
A:
[4-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
---------------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
276
Blastp_CBE
49.93
59%
-152
- C5 -
-
4RJ4
1
A:
[4-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
-----
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
-------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
Blastp_CBE
49.90
59%
-152
- C5 -
-
3POZ
1
A:
[6-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
------
V
K
I
P
-----
V
-
A
I
K
--
E
L
-------
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
G
A
-
E
E
K
-----------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
49.89
59%
-144
- C5 -
-
5X28
1
A:
[2-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
L
G
A
-
E
E
-------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Blastp_CBE
49.86
59%
-144
- C5 -
-
4G5J
3
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
----
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
----------
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
G
A
-
E
E
K
E
Y
H
-
A
E
G
---
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
168
Blastp_CBE
49.78
59%
-132
- C5 -
-
5GTZ
4
A:
[6-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
G
A
-
E
E
K
-----------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
269
Blastp_CBE
49.70
59%
-153
- C5 -
-
5C8N
1
A:
[4-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
---
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
-------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
49.66
59%
-144
- C5 -
-
5X2C
7
B:
[10-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
----------------
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
177
Blastp_CBE
49.59
59%
-147
- C5 -
-
5GMP
1
A:
[6-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
G
A
----------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
49.57
59%
-145
- C5 -
-
4LQM
1
A:
[6-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
---
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
L
G
A
-
E
E
-----------
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
49.51
59%
-155
- C5 -
-
3BBT
1
D:
[8-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
R
I
L
K
E
T
E
L
K
R
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
I
W
-
V
-
P
----
E
T
V
K
I
P
-----
V
-
A
I
K
--
I
L
N
E
---
P
K
A
N
V
E
F
M
D
E
A
L
I
----
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
--
L
-
S
P
T
-
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
-
H
K
D
--
N
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
-
R
-------------------------
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
R
E
I
P
D
L
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
---
A
E
F
S
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
49.50
61%
-142
- C5 -
-
3RCD
1
ERBB2_HUMAN
A:
[9-319]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
I
W
-
I
-
P
-
D
-
G
E
N
V
K
I
P
-----
V
-
A
I
K
--
V
L
R
----
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
-
N
R
G
--
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
-----------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
---
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
L
G
P
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
49.47
59%
-152
- C5 -
-
4I24
1
EGFR_HUMAN
A:
[7-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
-------
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
49.46
61%
-142
- C5 -
-
3RCD
1
ERBB2_HUMAN
C:
[9-319]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
I
W
-
I
-
P
-
D
-
G
E
N
V
K
I
P
-----
V
-
A
I
K
--
V
L
R
----
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
-
N
R
G
--
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
-----------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
---
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
L
G
P
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
49.44
59%
-156
- C5 -
-
5CAO
1
A:
[4-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
---
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
----------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
49.40
59%
-144
- C5 -
-
5UWD
1
A:
[9-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-
K
L
L
-----------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
231
Blastp_CBE
49.40
59%
-149
- C5 -
-
6P1D
1
?
A:
[5-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
------------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
183
Blastp_CBE
49.34
60%
-151
- C5 -
-
3BEL
1
A:
[2-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
------
V
K
I
P
-----
V
-
A
I
K
--
E
L
------
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
G
A
-
E
E
------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
49.33
59%
-149
- C5 -
-
3GT8
1
EGFR_HUMAN
B:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
------------------------
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
275
Blastp_CBE
49.30
59%
-160
- C5 -
-
4RJ5
1
A:
[4-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
----
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
----------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
49.27
59%
-143
- C5 -
-
5CNN
1
EGFR_HUMAN
A:
[7-290]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
N
Q
A
L
L
R
Q
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
---
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
------------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
49.10
59%
-156
- C5 -
-
5EM5
1
A:
[4-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
----
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
----------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
219
Blastp_CBE
48.86
59%
-156
- C5 -
-
5Y25
1
A:
[10-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
---
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
----------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
48.72
59%
-150
- C5 -
-
5ZTO
1
A:
[6-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
S
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
---------------------------
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
159
Blastp_CBE
48.70
59%
-151
- C5 -
-
3GT8
1
EGFR_HUMAN
A:
[8-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
------------------------
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
48.42
59%
-147
- C5 -
-
6P1L
1
?
B:
[7-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
---------------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
48.40
59%
-148
- C5 -
-
3LZB
1
EGFR_HUMAN
A:
[8-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
----------------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
48.06
58%
-146
- C5 -
-
5ZWJ
1
A:
[29-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
M
Q
L
M
P
F
G
S
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
-----------------------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
47.81
59%
-146
- C5 -
-
3LZB
1
EGFR_HUMAN
B:
[8-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
----------------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Blastp_CBE
47.45
59%
-50
- C5 -
-
4RIX
1
D:
[11-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
G
A
-
E
E
K
E
Y
H
-
A
E
G
---
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
47.04
59%
-50
- C5 -
-
4RIY
1
D:
[11-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
G
A
-
E
E
K
E
Y
H
-
A
E
G
---
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
Blastp_CBE
46.72
59%
-46
- C5 -
-
4RIX
1
EGFR_HUMAN
B:
[11-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
G
A
-
E
E
K
E
Y
H
-
A
-------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
46.55
59%
-144
- C5 -
-
3LZB
1
EGFR_HUMAN
C:
[9-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
-----
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
----------------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
46.42
59%
-45
- C5 -
-
4RIW
1
EGFR_HUMAN
B:
[11-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
G
A
-
E
E
K
E
Y
H
-
A
-------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
46.34
59%
-144
- C5 -
-
3LZB
1
EGFR_HUMAN
D:
[8-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
----
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
----------------------
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
Blastp_CBE
46.28
59%
-47
- C5 -
-
4RIW
1
D:
[11-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
G
A
-
E
E
K
E
Y
H
-
A
E
G
---
G
K
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Blastp_CBE
46.23
59%
-47
- C5 -
-
4RIY
1
EGFR_HUMAN
B:
[11-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
E
A
P
-
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
L
W
-
I
-
P
-
E
-
G
E
K
V
K
I
P
-----
V
-
A
I
K
--
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
----
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
--
L
-
T
S
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
D
--
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
-
K
L
L
G
A
-
E
E
K
E
Y
H
-
A
-------
V
----
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
---
I
E
F
S
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
45.76
63%
-46
- C5 -
-
2R4B
1
B:
[16-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
-
G
T
A
P
N
Q
A
Q
L
R
I
L
K
E
T
E
L
K
R
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
I
W
-
V
-
P
-
E
-
G
E
T
V
K
I
P
-----
V
-
A
I
K
--
I
L
-------
A
N
V
E
F
M
D
E
A
L
I
----
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
--
L
-
S
P
T
-
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
-
H
K
D
--
N
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
-
R
L
L
E
G
-
D
E
K
E
Y
N
-
A
D
G
---
G
K
M
----
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
R
E
I
P
D
L
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
---
A
E
F
S
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
45.71
63%
-48
- C5 -
-
2R4B
1
ERBB4_HUMAN
A:
[16-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
-
G
T
A
P
N
Q
A
Q
L
R
I
L
K
E
T
E
L
K
R
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
-
I
W
-
V
-
P
-
E
-
G
E
T
V
K
I
P
-----
V
-
A
I
K
--
I
L
N
------
A
N
V
E
F
M
D
E
A
L
I
----
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
--
L
-
S
P
T
-
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
-
H
K
D
--
N
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
-
R
L
L
E
G
-
D
E
K
E
Y
N
-
A
D
G
---
G
K
M
----
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
R
E
I
P
D
L
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
---
A
E
F
S
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
548
Blastp_CBE
37.99
33%
-69
- C5 -
-
4D58
1
?
B:
[16-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
-
E
-
N
P
A
M
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
F
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
-
R
Y
M
------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
37.55
39%
-40
- C5 -
-
3EQR
1
ACK1_HUMAN
B:
[4-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
E
K
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
-
E
W
D
A
-
P
-
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
K
PD
V
L
S
Q
P
E
A
M
D
D
F
I
R
E
V
N
---
A
----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
--
L
-
T
P
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
G
--
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
-
R
A
L
P
Q
N
D
D
H
Y
V
M
-------
R
K
V
----
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
---
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
470
Blastp_CBE
37.36
33%
-65
- C5 -
-
4K9Y
1
A:
[19-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
-
E
-
N
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-
R
Y
M
E
--
D
S
T
Y
Y
K
-
A
S
K
---
G
K
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
37.24
35%
-68
- C5 -
-
3ET7
1
A:
[14-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
-
V
Y
-
T
-
N
H
K
-
G
E
--
K
I
N
-----
V
-
A
V
K
--
T
C
K
K
D
C
T
L
D
N
K
E
K
F
M
S
E
A
V
I
----
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
--
E
-
E
E
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
N
--
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
-
R
------------------
T
R
L
----
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
CSL
S
D
V
Y
Q
M
E
K
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
37.11
35%
-66
- C5 -
-
4H1M
1
A:
[30-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
-
V
Y
-
T
-
N
H
K
-
G
E
--
K
I
N
-----
V
-
A
V
K
--
T
C
K
K
D
C
T
L
D
N
K
E
K
F
M
S
E
A
V
I
----
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
--
E
-
E
E
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
N
--
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
----------------------
L
----
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
CSL
S
D
V
Y
Q
M
E
K
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
379
Blastp_CBE
37.11
35%
-62
- C5 -
-
3FZT
1
A:
[14-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
-
V
Y
-
T
-
N
H
K
-
G
E
--
K
I
N
-----
V
-
A
V
K
--
T
C
K
K
D
C
T
L
D
N
K
E
K
F
M
S
E
A
V
I
----
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
--
E
-
E
E
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
N
--
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
-
R
------------------
T
R
L
----
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
CSL
S
D
V
Y
Q
M
E
K
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
37.09
39%
-30
- C5 -
-
3EQR
1
ACK1_HUMAN
A:
[4-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
E
K
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
-
E
W
D
A
-
P
-
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
K
------
P
E
A
M
D
D
F
I
R
E
V
N
---
A
----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
--
L
-
T
P
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
G
--
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
-
R
A
L
P
Q
N
D
D
H
Y
V
M
-
Q
E
H
---
R
K
V
----
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
---
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
37.04
35%
-64
- C5 -
-
3FZR
1
A:
[14-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
-
V
Y
-
T
-
N
H
K
-
G
E
--
K
I
N
-----
V
-
A
V
K
--
T
C
K
K
D
C
T
L
D
N
K
E
K
F
M
S
E
A
V
I
----
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
--
E
-
E
E
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
N
--
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
-
R
------------------
T
R
L
----
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
CSL
S
D
V
Y
Q
M
E
K
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
36.99
35%
-31
- C5 -
-
2QOC
2
A:
[10-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
-
L
-
P
-
S
-
K
K
E
I
S
V
A
-----
I
K
T
L
K
--
V
G
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
-------
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
--
T
-
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
-
H
D
A
--
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
-
R
V
L
E
--
D
-------------
K
I
----
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
-
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
---
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
543
Blastp_CBE
36.95
33%
-76
- C5 -
-
6GCX
1
FAK1_CHICK
A:
[16-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
-
E
-
N
P
A
M
--
A
-----
V
-
A
I
K
--
T
C
K
N
--
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
F
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
-
R
--------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
36.89
35%
-62
- C5 -
-
3FZS
1
A:
[14-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
-
V
Y
-
T
-
N
H
K
-
G
E
--
K
I
N
-----
V
-
A
V
K
--
T
C
K
K
D
C
T
L
D
N
K
E
K
F
M
S
E
A
V
I
----
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
--
E
-
E
E
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
N
--
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
------------------------
L
----
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
CSL
S
D
V
Y
Q
M
E
K
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
553
Blastp_CBE
36.79
33%
-67
- C5 -
-
4D4V
2
B:
[16-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
-
E
-
N
P
A
M
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
F
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
------------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
36.59
33%
-36
- C5 -
-
2FO0
3
ABL1_HUMAN
A:
[214-488]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
482
Blastp_CBE
36.60
33%
-69
- C5 -
-
4GU6
1
B:
[19-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
-
E
-
N
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-
R
--------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
407
Blastp_CBE
36.59
35%
-61
- C5 -
-
4H1J
1
A:
[30-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
-
V
Y
-
T
-
N
H
K
-
G
E
--
K
I
N
-----
V
-
A
V
K
--
T
C
K
K
D
C
T
L
D
N
K
E
K
F
M
S
E
A
V
I
----
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
--
E
-
E
E
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
N
--
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
-
R
------------
A
S
V
---
T
R
L
----
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
CSL
S
D
V
Y
Q
M
E
K
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
322
Blastp_CBE
36.55
37%
-76
- C5 -
-
4CSV
1
?
A:
[11-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
-
K
W
--------
R
N
Y
N
I
E
-----
V
-
A
V
K
--
T
L
--
K
E
G
T
M
S
V
E
E
F
L
Q
E
A
Q
I
----
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
--
T
-
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
-
C
-----
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
------------------------
F
----
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
-
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
---
H
A
L
E
T
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
433
Blastp_CBE
36.51
33%
-31
- C5 -
-
1OPK
3
ABL1_MOUSE
A:
[217-491]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
339
Blastp_CBE
36.53
33%
-39
- C5 -
-
2HZI
1
ABL1_HUMAN
A:
[10-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
---
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
36.51
39%
-29
- C5 -
-
1U54
1
ACK1_HUMAN
B:
[14-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
E
K
D
L
R
L
L
E
K
L
G
D
---
G
V
V
R
R
G
-
E
W
D
A
-
P
-
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
--------
E
A
M
D
D
F
I
R
E
V
N
---
A
----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
--
L
-
T
P
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
G
--
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
-
R
A
L
P
Q
N
D
D
H
Y
V
M
-
Q
E
H
---
R
K
V
----
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
---
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
484
Blastp_CBE
36.50
33%
-73
* C5 *
-
3PXK
1
B:
[19-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
-
E
-
N
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
-----------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
547
Blastp_CBE
36.44
33%
-68
- C5 -
-
4D5H
1
FAK1_CHICK
A:
[16-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
-
E
-
N
P
A
M
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
F
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
------------------------
K
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
36.47
33%
-69
- C5 -
-
2JKM
1
A:
[16-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
-
E
-
N
P
A
M
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-
R
--------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
36.44
33%
-71
- C5 -
-
4KAB
1
B:
[19-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
-
E
--
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-
R
Y
M
------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
36.43
33%
-31
- C5 -
-
1OPL
2
ABL1_HUMAN
A:
[256-530]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
489
Blastp_CBE
36.39
33%
-69
- C5 -
-
2ETM
1
FAK1_HUMAN
A:
[18-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
-
E
-
N
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-
R
Y
M
E
----------------
K
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
285
Blastp_CBE
36.38
39%
-28
- C5 -
-
4EWH
1
ACK1_HUMAN
A:
[4-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
E
K
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
-
E
W
D
A
-
P
-
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
K
PD
V
L
S
Q
P
E
A
M
D
D
F
I
R
E
V
N
---
A
----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
--
L
-
T
P
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
G
--
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
-
R
A
L
P
Q
-
N
D
D
H
V
M
-
Q
E
H
---
R
K
V
----
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
---
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
491
Blastp_CBE
36.36
33%
-71
- C5 -
-
2JKQ
1
A:
[16-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
-
E
-
N
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
----------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
36.35
33%
-64
- C5 -
-
4K8A
1
B:
[19-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
-
E
-
N
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-
R
Y
-------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
487
Blastp_CBE
36.32
33%
-72
- C5 -
-
2IJM
1
FAK1_HUMAN
A:
[18-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
-
E
-
N
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
----------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
488
Blastp_CBE
36.29
33%
-66
- C5 -
-
2ETM
1
B:
[18-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
-
E
-
N
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-
R
--------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
36.23
33%
-72
- C5 -
-
6I8Z
1
A:
[18-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
-
E
-
N
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-
R
--------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
36.22
33%
-69
- C5 -
-
2J0M
1
?
B:
[16-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
-
E
-
N
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
-----------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
556
Blastp_CBE
36.20
33%
-61
- C5 -
-
4D4S
2
FAK1_CHICK
A:
[16-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
-
E
-
N
P
A
M
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
F
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
------------------------
K
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
36.19
33%
-38
- C5 -
-
1OPL
1
ABL1_HUMAN
B:
[256-518]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
36.18
33%
-68
- C5 -
-
3PXK
1
FAK1_HUMAN
A:
[19-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
-
E
-
N
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
------------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
36.17
39%
-33
- C5 -
-
3EQP
1
ACK1_HUMAN
A:
[4-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
E
K
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
-
E
W
D
A
-
P
-
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
------
Q
P
E
A
M
D
D
F
I
R
E
V
N
---
A
----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
--
L
-
T
P
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
G
--
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
-
R
A
L
P
Q
N
D
D
H
Y
V
M
-
Q
E
H
---
R
K
V
----
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
---
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
36.12
33%
-67
- C5 -
-
2IJM
1
B:
[18-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
-
E
-
N
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
----------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
434
Blastp_CBE
36.10
34%
-41
- C5 -
-
3OY3
1
ABL1_MOUSE
B:
[21-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
382
Blastp_CBE
36.07
35%
-63
- C5 -
-
3FZP
1
A:
[14-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
-
V
Y
-
T
-
N
H
K
-
G
E
--
K
I
N
-----
V
-
A
V
K
--
T
C
K
K
D
C
T
L
D
N
K
E
K
F
M
S
E
A
V
I
----
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
--
E
-
E
E
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
N
--
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
----------------------
T
R
L
----
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
CSL
S
D
V
Y
Q
M
E
K
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
473
Blastp_CBE
35.95
33%
-72
- C5 -
-
4GU9
1
B:
[19-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
----
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-
R
Y
M
------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
554
Blastp_CBE
35.93
33%
-64
- C5 -
-
4D4V
2
FAK1_CHICK
A:
[16-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
-
E
-
N
P
A
M
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
F
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
-----------------------
G
K
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
35.91
39%
-31
- C5 -
-
1U4D
1
ACK1_HUMAN
A:
[14-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
E
K
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
-
E
W
D
A
-
P
-
S
-
G
K
T
V
S
V
A
-----
V
K
C
--------
P
E
A
M
D
D
F
I
R
E
V
N
---
A
----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
--
L
-
T
P
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
G
--
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
-
R
A
L
P
Q
--
D
H
Y
V
M
---------
V
----
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
---
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
35.84
34%
-50
- C5 -
-
2Z60
1
ABL1_MOUSE
A:
[21-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
-----
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
35.80
33%
-59
- C5 -
-
4GU6
1
FAK1_HUMAN
A:
[19-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S----
N
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-
R
Y
M
E
--
D
S
T
Y
Y
K
-
A
S
K
---
G
K
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
35.73
35%
-70
- C5 -
-
3H3C
1
A:
[14-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
-
V
Y
-
T
-
N
H
K
-
G
E
--
K
I
N
-----
V
-
A
V
K
--
T
C
K
K
D
C
T
L
D
N
K
E
K
F
M
S
E
A
V
I
----
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
--
E
-
E
E
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
N
--
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
---------------------
T
R
L
----
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
CSL
S
D
V
Y
Q
M
E
K
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
35.66
39%
-28
- C5 -
-
4EWH
1
ACK1_HUMAN
B:
[4-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
E
K
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
-
E
W
D
A
-
P
-
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
K
PD
V
L
S
Q
P
E
A
M
D
D
F
I
R
E
V
N
---
A
----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
--
L
-
T
P
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
G
--
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
-
R
A
L
P
Q
-
N
D
D
H
V
M
-
Q
E
H
---
R
K
V
----
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
---
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
35.62
33%
-72
- C5 -
-
4GU9
1
FAK1_HUMAN
A:
[19-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
----
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
-------------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
35.62
39%
-33
- C5 -
-
3EQP
1
ACK1_HUMAN
B:
[4-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
E
K
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
-
E
W
D
A
-
P
-
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
------
Q
P
E
A
M
D
D
F
I
R
E
V
N
---
A
----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
--
L
-
T
P
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
G
--
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
-
R
A
L
P
Q
N
D
D
H
Y
V
M
-
Q
E
H
---
R
K
V
----
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
---
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
490
Blastp_CBE
35.50
36%
-59
- C5 -
-
3PLS
1
A:
[27-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
I
G
K
G
H
F
G
V
V
Y
H
G
-
E
Y
-
I
-
D
-
Q
-
A
Q
N
-
R
I
Q
-----
C
-
A
I
K
--
S
L
S
R
I
T
E
M
Q
Q
V
E
A
F
L
R
E
G
L
L
----
M
R
G
L
N
H
P
N
V
L
A
L
I
G
I
M
LP
P
-
E
G
L
-
P
H
V
L
L
P
Y
M
C
H
G
D
L
L
Q
F
I
R
S
-
P
Q
R
--
N
P
T
V
K
D
L
I
S
F
G
L
Q
V
A
R
G
M
E
Y
L
A
E
Q
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
S
F
T
V
K
V
A
D
F
G
L
A
R
D
I
L
D
R
-
E
Y
Y
S
V
Q
Q
H
R
H
---
A
R
L
----
P
V
K
W
T
A
L
E
S
L
Q
T
Y
R
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
L
T
R
G
A
P
P
Y
R
H
I
D
P
F
D
L
T
H
F
L
A
Q
-
G
R
R
L
P
Q
P
E
Y
C
P
D
S
L
Y
Q
V
M
Q
Q
C
W
E
A
D
P
A
V
R
P
T
F
R
V
L
V
---
G
E
V
E
Q
I
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
435
Blastp_CBE
35.50
34%
-40
- C5 -
-
3OY3
1
ABL1_MOUSE
A:
[21-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
35.46
39%
-32
- C5 -
-
5WNO
1
A:
[21-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
Q
T
K
L
D
K
K
L
G
A
G
A
F
G
T
V
F
A
G
-
I
Y
-
Y
-
P
-
K
R
A
-
N
V
K
I
P
-----
V
-
A
I
K
--
V
F
------
Q
T
D
Q
S
Q
T
D
E
M
L
E
EATN
M
F
R
L
R
H
D
N
L
L
K
I
I
G
F
C
--
M
H
D
D
G
-
L
K
I
V
T
I
Y
R
P
L
G
N
L
Q
N
F
L
K
L
-
H
K
E
--
N
L
G
A
R
E
Q
V
L
Y
C
Y
Q
I
A
S
G
M
Q
Y
L
E
K
Q
R
V
V
H
R
D
L
A
T
R
N
V
L
V
K
K
F
N
H
V
E
I
T
D
F
G
L
S
-
K
I
L
-----------------
K
V
----
A
I
K
W
L
A
I
E
I
F
S
K
H
C
Y
T
H
A
S
D
V
W
A
F
G
V
T
C
W
E
I
I
T
F
G
Q
S
P
Y
Q
G
M
S
T
D
S
I
H
N
F
L
K
D
-
G
N
R
L
S
Q
P
P
N
C
S
Q
D
L
Y
Q
E
L
L
R
C
W
M
A
D
P
K
S
R
P
G
F
E
I
L
Y
---
E
R
F
K
E
F
C
K
V
P
Q
L
F
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
338
Blastp_CBE
35.41
33%
-46
- C5 -
-
2HZI
1
ABL1_HUMAN
B:
[10-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
---
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
------
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
35.40
39%
-30
- C5 -
-
1U4D
1
ACK1_HUMAN
B:
[14-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
E
K
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
-
E
W
D
A
-
P
-
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
---------
A
M
D
D
F
I
R
E
V
N
---
A
----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
--
L
-
T
P
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
-----
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
-
R
A
L
P
Q
N
D
D
H
Y
V
M
-
Q
E
H
---
R
K
V
----
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
---
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
35.38
39%
-22
- C5 -
-
4ID7
1
ACK1_HUMAN
A:
[4-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
E
K
D
L
R
L
L
E
K
L
G
D
G
S
F
G
V
V
R
R
G
-
E
W
D
A
-
P
-
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
K
P-----
P
E
A
M
D
D
F
I
R
E
V
N
---
A
----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
--
L
-
T
P
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
G
--
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
-
R
A
L
P
Q
N
D
D
H
Y
V
M
-
Q
E
H
---
R
K
V
----
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
---
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
35.32
33%
-68
- C5 -
-
4I4E
1
A:
[21-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
---
N
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
-------------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
35.30
34%
-40
- C5 -
-
3IK3
1
ABL1_MOUSE
B:
[21-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
517
Blastp_CBE
35.17
38%
-40
- C5 -
-
4XG3
1
B:
[20-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
N
E
A
N
D
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
--KW--
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
449
Blastp_CBE
35.12
33%
-46
- C5 -
-
5MO4
2
ABL1_HUMAN
A:
[217-491]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
----
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
-------------------------
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
35.11
33%
-36
- C5 -
-
3CS9
1
ABL1_HUMAN
D:
[10-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
---
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
-------------
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
323
Blastp_CBE
35.11
37%
-39
- C5 -
-
4XLI
1
B:
[12-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
V
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
S
R
E
--
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
-
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
---
Q
A
F
E
T
M
F
H
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
35.10
34%
-43
- C5 -
-
1M52
3
ABL1_MOUSE
B:
[26-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
35.09
33%
-67
- C5 -
-
4KAB
1
FAK1_HUMAN
A:
[19-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
----
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
-------------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
35.06
33%
-69
- C5 -
-
4KAO
1
B:
[19-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
----
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
------------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
467
Blastp_CBE
34.95
33%
-49
- C5 -
-
2J0L
1
A:
[16-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
-
E
-
N
P
A
M
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
F
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-
R
Y
M
E
D
-
S
T
K
A
----
S
K
---
G
K
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
34.82
34%
-43
- C5 -
-
4TWP
1
ABL1_HUMAN
B:
[16-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
34.79
37%
-39
- C5 -
-
3HMI
1
ABL2_HUMAN
A:
[40-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
V
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
E
--
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
-
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
---
Q
A
F
E
T
M
F
H
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
540
Blastp_CBE
34.78
33%
-66
- C5 -
-
3BZ3
1
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
------
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-
R
Y
-------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
34.74
33%
-36
- C5 -
-
3CS9
1
ABL1_HUMAN
A:
[10-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
---
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
------
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
34.69
34%
-38
- C5 -
-
4ZOG
5
ABL1_HUMAN
A:
[20-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
367
Blastp_CBE
34.66
34%
-42
- C5 -
-
1M52
1
ABL1_MOUSE
A:
[26-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
34.63
34%
-37
- C5 -
-
4XEY
1
ABL1_HUMAN
A:
[129-388]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
34.65
33%
-65
- C5 -
-
4K8A
1
FAK1_HUMAN
A:
[19-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
----
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
------------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
34.63
37%
-46
- C5 -
-
2XYN
2
ABL2_HUMAN
A:
[40-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
V
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
E
--
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
-
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
---
Q
A
F
E
T
M
F
H
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
283
Blastp_CBE
34.61
39%
-30
- C5 -
-
1U54
1
ACK1_HUMAN
A:
[14-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
E
K
D
L
R
L
L
E
K
L
G
D
---
G
V
V
R
R
G
-
E
W
D
A
-
P
-
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
---------
A
M
D
D
F
I
R
E
V
N
---
A
----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
--
L
-
T
P
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
G
--
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
-
R
A
L
P
Q
-
N
D
D
H
V
M
-
Q
E
H
---
R
K
-----
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
---
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
539
Blastp_CBE
34.58
38%
-44
- C5 -
-
1XBB
1
A:
[23-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
-----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
--KW--
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
34.56
35%
-64
- C5 -
-
5TOB
1
A:
[19-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
-
V
Y
-
T
--H
K
-
G
E
--
K
I
N
-----
V
-
A
V
K
--
T
C
K
-----
D
N
K
E
K
F
M
S
E
A
V
I
----
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
-----
E
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
N
--
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
-----------------------------
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
CSL
S
D
V
Y
Q
M
E
K
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
34.52
33%
-68
- C5 -
-
4KAO
1
FAK1_HUMAN
A:
[19-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S-----
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
------------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
528
Blastp_CBE
34.48
38%
-22
- C5 -
-
4GFG
1
A:
[23-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
N
E
A
N
D
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
Q
T
HGKW
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
534
Blastp_CBE
34.46
38%
-42
- C5 -
-
3FQS
1
A:
[23-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
-----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
--KW--
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
34.42
35%
-37
- C5 -
-
6BL8
1
ABL1_HUMAN
A:
[16-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
F
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
34.40
33%
-66
- C5 -
-
4Q9S
1
A:
[21-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
----
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
--------------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
343
Blastp_CBE
34.38
34%
-35
- C5 -
-
4ZOG
2
ABL1_HUMAN
B:
[20-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
---
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
542
Blastp_CBE
34.32
33%
-60
- C5 -
-
4EBV
3
A:
[44-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
-
E
-
N
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
----------------------
K
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
34.37
34%
-23
- C5 -
-
2G2H
1
ABL1_HUMAN
A:
[23-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
G
-
D
T
-----
Y
T
A
PAG
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
34.32
34%
-34
- C5 -
-
3KFA
1
ABL1_MOUSE
A:
[21-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
530
Blastp_CBE
34.31
38%
-45
- C5 -
-
4FZ6
1
A:
[23-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
--
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
-----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
--KW--
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
349
Blastp_CBE
34.30
34%
-42
- C5 -
-
2QOH
1
ABL1_MOUSE
B:
[21-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
-----
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
34.29
34%
-30
- C5 -
-
3K5V
2
ABL1_MOUSE
A:
[26-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
---
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
398
Blastp_CBE
34.26
35%
-61
- C5 -
-
5TO8
1
A:
[19-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
-
V
Y
-
T
-
N
H
K
-
G
E
--
K
I
N
-----
V
-
A
V
K
--
T
C
K
K
D
C
T
--
N
K
E
K
F
M
S
E
A
V
I
----
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
-----
E
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
N
--
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
--
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
-
R
--------------------------
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
CSL
S
D
V
Y
Q
M
E
K
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
508
Blastp_CBE
34.25
38%
-41
- C5 -
-
5GHV
1
B:
[20-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
N
----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
--KW--
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
526
Blastp_CBE
34.19
38%
-44
- C5 -
-
4I0S
1
A:
[23-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
------
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
--KW--
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
34.19
34%
-35
- C5 -
-
3KFA
1
ABL1_MOUSE
B:
[21-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
34.17
34%
-56
- C5 -
-
2V7A
1
ABL1_HUMAN
B:
[22-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
G
-
D
T
T
A
---
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
340
Blastp_CBE
34.19
34%
-41
- C5 -
-
4WA9
1
ABL1_HUMAN
B:
[22-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
34.18
37%
-40
- C5 -
-
4XLI
1
ABL2_MOUSE
A:
[16-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
V
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
------
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
S
R
E
--
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
-
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
---
Q
A
F
E
T
M
F
H
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
34.17
34%
-29
- C5 -
-
2F4J
1
ABL1_HUMAN
A:
[22-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
G
-
D
T
-----
Y
T
A
PAG
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
509
Blastp_CBE
34.12
38%
-41
- C5 -
-
5GHV
1
KSYK_HUMAN
A:
[20-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
N
----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
--KW--
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
34.13
34%
-36
- C5 -
-
2G1T
1
ABL1_HUMAN
C:
[23-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
432
Blastp_CBE
34.12
34%
-31
- C5 -
-
2G2F
1
ABL1_HUMAN
A:
[23-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
G
-
D
T
-----
Y
T
A
PAG
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
529
Blastp_CBE
34.00
38%
-47
- C5 -
-
4FZ7
1
A:
[23-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
--
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
------
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
--KW--
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
34.04
37%
-43
- C5 -
-
4UEU
1
?
A:
[11-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
-
K
W
--------
R
N
Y
N
I
E
-----
V
-
A
V
K
--
T
L
--
K
E
G
T
M
S
V
E
E
F
L
Q
E
A
Q
I
----
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
--
T
-
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
-
C
E
G
H-
T
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
L
A
-
R
L
I
----------------
A
K
F
----
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
-
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
---
H
A
L
E
T
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
400
Blastp_CBE
34.03
35%
-41
- C5 -
-
2HZ4
1
ABL1_HUMAN
B:
[16-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
350
Blastp_CBE
34.02
34%
-44
- C5 -
-
2QOH
1
ABL1_MOUSE
A:
[21-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
-----
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
341
Blastp_CBE
34.00
34%
-65
- C5 -
-
4WA9
1
ABL1_HUMAN
A:
[22-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
----------------------------
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
---
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
33.98
34%
-41
- C5 -
-
3UE4
1
ABL1_HUMAN
B:
[23-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
--
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
33.95
34%
-27
- C5 -
-
1OPJ
2
ABL1_MOUSE
B:
[26-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
33.94
34%
-37
- C5 -
-
2G2I
1
ABL1_HUMAN
B:
[19-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
G
-
D
T
-----
Y
T
A
PAG
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
33.93
34%
-30
- C5 -
-
2G1T
1
ABL1_HUMAN
D:
[23-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
33.92
35%
-40
- C5 -
-
3QRJ
1
ABL1_HUMAN
B:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
541
Blastp_CBE
33.86
33%
-66
- C5 -
-
4EBW
1
A:
[44-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S----
N
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
----------------------
K
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
33.90
34%
-31
- C5 -
-
2G1T
1
ABL1_HUMAN
B:
[23-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
516
Blastp_CBE
33.86
38%
-40
- C5 -
-
4XG4
1
A:
[20-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
-----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
--KW--
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
33.89
34%
-41
- C5 -
-
3DK3
1
ABL1_MOUSE
A:
[19-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
------
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
F
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
33.84
38%
-43
- C5 -
-
4FYN
1
A:
[23-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
-
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
-----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
--KW--
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
531
Blastp_CBE
33.84
38%
-44
- C5 -
-
4FYO
1
A:
[23-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
------
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
--KW--
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
425
Blastp_CBE
33.88
34%
-37
- C5 -
-
3IK3
1
ABL1_MOUSE
A:
[21-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---------
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
33.85
34%
-42
- C5 -
-
4TWP
1
ABL1_HUMAN
A:
[16-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
-------
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
33.87
38%
-35
- C5 -
-
4I0R
1
A:
[22-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
---
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
-----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
--KW--
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
33.85
35%
-52
- C5 -
-
2GQG
2
ABL1_HUMAN
A:
[26-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
G
-
D
T
T
A
---
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
374
Blastp_CBE
33.85
35%
-49
- C5 -
-
2GQG
2
ABL1_HUMAN
B:
[26-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
G
-
D
T
T
A
---
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
33.86
34%
-37
- C5 -
-
3UE4
1
ABL1_HUMAN
A:
[23-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
33.85
34%
-44
- C5 -
-
3KF4
1
ABL1_MOUSE
A:
[21-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
-------
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
369
Blastp_CBE
33.84
34%
-37
- C5 -
-
1IEP
1
ABL1_MOUSE
A:
[26-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
33.83
34%
-30
- C5 -
-
2G1T
1
ABL1_HUMAN
A:
[23-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
33.77
39%
-33
- C5 -
-
5ZXB
1
ACK1_HUMAN
A:
[4-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
E
K
D
L
R
L
L
E
K
L
G
D
---
G
V
V
R
R
G
-
E
W
D
A
-
P
-
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
---------
A
M
D
D
F
I
R
E
V
N
---
A
----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
--
L
-
T
P
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
G
--
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
------------------------------
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
---
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
354
Blastp_CBE
33.76
34%
-28
- C5 -
-
6HD4
3
ABL1_MOUSE
A:
[26-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
---
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
537
Blastp_CBE
33.74
38%
-31
- C5 -
-
3FQE
1
A:
[23-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
-----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
Q
-KW--
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
521
Blastp_CBE
33.72
38%
-39
- C5 -
-
5T68
1
B:
[23-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
-----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
--KW--
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
33.67
35%
-32
- C5 -
-
2HZ0
1
ABL1_HUMAN
A:
[21-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
429
Blastp_CBE
33.65
34%
-27
- C5 -
-
2G2H
1
ABL1_HUMAN
B:
[23-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
G
-
D
T
-----
Y
T
A
PAG
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
33.61
37%
-42
- C5 -
-
2XYN
4
ABL2_HUMAN
C:
[40-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
V
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
--
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
E
--
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
-
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
---
Q
A
F
E
T
M
F
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
520
Blastp_CBE
33.56
38%
-26
- C5 -
-
5TIU
1
A:
[18-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
---------
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
Q
T
HGKW
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
33.56
35%
-38
- C5 -
-
3QRK
1
ABL1_HUMAN
A:
[26-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
373
Blastp_CBE
33.56
34%
-33
- C5 -
-
2HIW
1
ABL1_HUMAN
A:
[23-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
506
Blastp_CBE
33.52
33%
-64
- C5 -
-
1MP8
1
A:
[21-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S
P
----
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
--------------------------
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
533
Blastp_CBE
33.55
38%
-27
- C5 -
-
4FL1
1
A:
[23-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
-----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
Q
T
HGKW
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
33.52
34%
-40
- C5 -
-
4YC8
3
ABL1_HUMAN
B:
[17-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
522
Blastp_CBE
33.48
38%
-45
- C5 -
-
5T68
1
KSYK_HUMAN
A:
[23-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
-----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
--KW--
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
33.52
34%
-28
- C5 -
-
1OPJ
2
ABL1_MOUSE
A:
[26-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
33.48
37%
-41
- C5 -
-
2XYN
4
ABL2_HUMAN
B:
[40-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
V
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
E
--
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
-
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
---
Q
A
F
E
T
M
F
H
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
33.46
35%
-36
- C5 -
-
3QRI
1
ABL1_HUMAN
A:
[26-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
33.46
34%
-33
- C5 -
-
1FPU
1
ABL1_MOUSE
A:
[26-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
33.41
38%
-20
- C5 -
-
4XG7
1
A:
[15-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
N
E
A
--
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
Q
T
HGKW
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
33.41
34%
-29
- C5 -
-
6HD6
2
ABL1_MOUSE
A:
[26-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
----
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
33.38
38%
-20
- C5 -
-
4XG6
1
A:
[20-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
N
E
A
N
D
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
Q
T
H---
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
33.37
35%
-45
- C5 -
-
3QRJ
1
ABL1_HUMAN
A:
[26-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
-------
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
33.35
38%
-29
- C5 -
-
5TR6
2
A:
[23-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
------
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
Q
T
HGKW
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
353
Blastp_CBE
33.34
34%
-28
- C5 -
-
6HD4
2
ABL1_MOUSE
B:
[26-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
-----
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
33.30
38%
-25
- C5 -
-
4PV0
1
A:
[13-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
--
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
-----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
Q
T
HGKW
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
33.29
34%
-30
- C5 -
-
3K5V
2
ABL1_MOUSE
B:
[26-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
-----
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
33.22
38%
-26
- C5 -
-
4DFL
2
A:
[13-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
---
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
--
V
V
K
T
-----
V
-
A
V
K
--
I
L
------
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
Q
T
HGKW
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
405
Blastp_CBE
33.14
35%
-34
- C5 -
-
2HYY
1
ABL1_HUMAN
A:
[21-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
-
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
33.13
34%
-38
- C5 -
-
6NPE
2
ABL1_HUMAN
A:
[34-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
-----
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
33.15
34%
-54
- C5 -
-
3DK7
1
ABL1_MOUSE
A:
[19-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
------
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
G
-
D
T
T
A
---
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
351
Blastp_CBE
33.14
34%
-30
- C5 -
-
6HD6
1
ABL1_MOUSE
B:
[26-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
-----
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
404
Blastp_CBE
33.13
35%
-38
- C5 -
-
2HYY
1
ABL1_HUMAN
B:
[21-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
-
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
538
Blastp_CBE
33.08
38%
-28
- C5 -
-
1XBC
1
A:
[23-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
------
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
Q
T
HGKW
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
479
Blastp_CBE
33.10
38%
-24
- C5 -
-
5Y5T
1
A:
[18-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
N
--------
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
Q
T
HGKW
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
33.08
33%
-60
- C5 -
-
4I4F
2
A:
[21-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
Y
-
M
S-----
P
A
L
--
A
-----
V
-
A
I
K
--
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
----
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
--
T
-
E
N
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
Y
--
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
---------------------
K
L
----
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
---
A
Q
L
S
T
I
L
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
32.99
38%
-21
- C5 -
-
5TT7
1
A:
[23-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
---
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
-----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
Q
T
HGKW
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
523
Blastp_CBE
32.97
38%
-32
- C5 -
-
4PUZ
1
B:
[23-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
-----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
Q
-KW--
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
33.01
34%
-39
- C5 -
-
3PYY
1
ABL1_HUMAN
A:
[34-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
----
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
32.99
35%
-40
- C5 -
-
3QRI
1
ABL1_HUMAN
B:
[26-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
-------
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
33.00
34%
-40
- C5 -
-
6NPV
2
ABL1_HUMAN
A:
[34-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
-----
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
372
Blastp_CBE
32.99
34%
-30
- C5 -
-
2HIW
1
ABL1_HUMAN
B:
[23-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
32.98
34%
-40
- C5 -
-
3MS9
2
ABL1_MOUSE
A:
[26-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--------
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
----
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
32.94
38%
-16
- C5 -
-
4RSS
1
A:
[20-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
N
E
A
--
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
Q
T
HGKW
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
32.97
38%
-24
- C5 -
-
5Y5U
1
B:
[23-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
N
----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
------
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
32.94
34%
-41
- C5 -
-
3DK3
1
ABL1_MOUSE
B:
[19-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
------
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
F
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
535
Blastp_CBE
32.96
38%
-38
- C5 -
-
3FQH
1
B:
[23-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
----
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
-----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
--KW--
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
525
Blastp_CBE
32.91
38%
-32
- C5 -
-
4I0T
1
A:
[23-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
------
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
--W---
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
32.94
34%
-22
- C5 -
-
2G2F
1
ABL1_HUMAN
B:
[18-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
G
-
D
T
-----
Y
T
A
PAG
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
403
Blastp_CBE
32.92
35%
-40
- C5 -
-
2HYY
1
ABL1_HUMAN
C:
[21-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
-
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
-----
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
524
Blastp_CBE
32.87
38%
-32
- C5 -
-
4PUZ
1
KSYK_HUMAN
A:
[23-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
-----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
Q
-KW--
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
32.91
38%
-25
- C5 -
-
4DFN
1
A:
[13-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
-----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
Q
T
HGKW
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
512
Blastp_CBE
32.85
38%
-20
- C5 -
-
4XG8
1
C:
[20-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
--
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
-----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
Q
-----
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
478
Blastp_CBE
32.87
38%
-26
- C5 -
-
5Y5U
1
KSYK_HUMAN
A:
[23-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
-----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
Q
T
HGKW
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
402
Blastp_CBE
32.85
35%
-37
- C5 -
-
2HYY
1
ABL1_HUMAN
D:
[21-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
----
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
32.78
35%
-36
- C5 -
-
6BL8
1
ABL1_HUMAN
B:
[16-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
---
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
F
T
A
-
H
-
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
32.75
34%
-42
- C5 -
-
4YC8
3
ABL1_HUMAN
A:
[17-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
------
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
32.72
34%
-38
- C5 -
-
6NPU
2
ABL1_HUMAN
A:
[34-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
-----
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
32.71
34%
-35
- C5 -
-
1IEP
1
ABL1_MOUSE
B:
[26-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
358
Blastp_CBE
32.67
34%
-38
- C5 -
-
3MSS
2
ABL1_MOUSE
A:
[26-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--------
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
---
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
32.67
34%
-40
- C5 -
-
3KF4
1
ABL1_MOUSE
B:
[21-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
---
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
370
Blastp_CBE
32.66
34%
-30
- C5 -
-
1FPU
1
ABL1_MOUSE
B:
[26-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
-------
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
342
Blastp_CBE
32.65
34%
-40
- C5 -
-
3OXZ
1
ABL1_MOUSE
A:
[21-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--------
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
--------------
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
336
Blastp_CBE
32.64
33%
-30
- C5 -
-
3CS9
1
ABL1_HUMAN
B:
[10-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
---
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
---
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
-----------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
32.62
37%
-28
- C5 -
-
3GVU
2
ABL2_HUMAN
A:
[40-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
V
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
E
--
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
-
R
-----
G
D
T
Y
T
--------
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
-
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
---
Q
A
F
E
T
M
F
H
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
356
Blastp_CBE
32.51
34%
-39
- C5 -
-
3MSS
2
ABL1_MOUSE
C:
[26-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--------
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
---
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
558
Fugue
32.48
35%
-28
- C5 -
-
1BYG
1
CSK_HUMAN
A:
[15-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
-
D
Y
-
R
G---------
N
K
-----
V
-
A
V
K
--
C
I
K
-----
N
D
A
Q
A
F
L
A
E
A
S
V
----
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V---
E
E
G
-
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
-
R
G
-RS
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
-----------------------
L
L
----
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L
K
D
V
V
P
R
V
E
K
-
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
---
E
Q
L
E
H
I
K
T
H
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
32.43
34%
-32
- C5 -
-
2HZN
1
ABL1_MOUSE
A:
[26-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
---
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
518
Blastp_CBE
32.29
38%
-24
- C5 -
-
4XG3
1
KSYK_HUMAN
A:
[15-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
-----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
Q
T
HGKW
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
32.26
34%
-23
- C5 -
-
2G2I
1
ABL1_HUMAN
A:
[23-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
---
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--
K
E
D
T
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
G
-
D
T
-----
Y
T
A
PAG
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
335
Blastp_CBE
32.28
33%
-43
- C5 -
-
3CS9
1
ABL1_HUMAN
C:
[9-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
---
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
-------
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
-----------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
32.27
39%
-25
- C5 -
-
5ZXB
1
ACK1_HUMAN
B:
[4-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
E
K
D
L
R
L
L
E
K
L
G
D
----
V
V
R
R
G
-
E
W
D
A
-
P
-
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
------
Q
P
E
A
M
D
D
F
I
R
E
V
N
---
A
----
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
--
L
-
T
P
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
G
--
H
F
-
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
------------------------------
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
R
---
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
32.26
34%
-38
- C5 -
-
2E2B
1
ABL1_HUMAN
A:
[26-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
------
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
------
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
395
Blastp_CBE
32.22
35%
-30
- C5 -
-
5HU9
13
ABL1_HUMAN
A:
[25-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
------------
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
32.16
34%
-36
- C5 -
-
3MSS
2
ABL1_MOUSE
D:
[26-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--------
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
---
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
513
Blastp_CBE
32.15
38%
-26
- C5 -
-
4XG8
1
KSYK_HUMAN
A:
[20-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
--
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
--
V
V
K
T
-----
V
-
A
V
K
--
I
L
-----
D
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
Q
T
H---
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
32.09
34%
-36
- C5 -
-
3MSS
2
ABL1_MOUSE
B:
[26-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--------
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
---
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
359
Blastp_CBE
32.06
34%
-34
- C5 -
-
3MS9
2
ABL1_MOUSE
B:
[26-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
---
T
--
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
--
G
D
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
32.00
38%
-27
- C5 -
-
4XG9
1
KSYK_HUMAN
A:
[20-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
-----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
------
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
32.01
34%
-41
- C5 -
-
6NPU
5
ABL1_HUMAN
B:
[34-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--------
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
-------------------
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
32.00
34%
-40
- C5 -
-
6NPE
3
ABL1_HUMAN
B:
[34-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--------
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
------------------------
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
510
Blastp_CBE
31.99
38%
-25
- C5 -
-
4XG9
1
B:
[20-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
----
D
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
Q
T
H---
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
31.77
34%
-52
- C5 -
-
3DK7
1
ABL1_MOUSE
B:
[19-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
------
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
G
-
D
T
T
A
---
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
536
Blastp_CBE
31.74
38%
-19
- C5 -
-
3FQH
1
KSYK_HUMAN
A:
[18-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
Y
-----
Q
-
M
K
K
V
V
K
T
-----
V
-
A
V
K
--
I
L
K
-----
P
---
A
L
K
D
E
L
L
A
EANV
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
--
E
-
A
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
-
D
E
N
----
Y
Y
K
---
A
Q
T
HGKW
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
-
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
421
Blastp_CBE
31.66
34%
-49
- C5 -
-
3DK6
1
ABL1_MOUSE
A:
[17-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
F
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
-------
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
G
-
D
T
T
A
---
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
408
Blastp_CBE
31.62
34%
-37
- C5 -
-
6NPV
5
ABL1_HUMAN
B:
[34-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--------
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
-------------------
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
31.23
34%
-33
- C5 -
-
3PYY
3
ABL1_HUMAN
B:
[34-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
--------
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
-------------------
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
376
Blastp_CBE
30.95
34%
-39
- C5 -
-
2E2B
1
ABL1_HUMAN
B:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
-------
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---------
T
Y
T
A
-
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
30.92
35%
-41
- C5 -
-
2HZ0
1
ABL1_HUMAN
B:
[15-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
------
M
E
V
E
E
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
----------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
28.48
34%
-9
- C5 -
-
5MJA
1
EPHB1_HUMAN
A:
[18-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
A
K
E
I
D
V
S
F
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
Y
K
G
------------
R
L
K
L
P
GKREI
V
-
A
I
K
--
T
L
K
A
G
Y
S
E
K
Q
R
R
D
F
L
S
E
A
S
I
----
M
G
Q
F
D
H
R
N
I
I
R
L
E
G
V
V
--
T
-
K
S
R
P
V
M
I
I
T
E
F
M
E
N
G
A
L
D
S
F
L
R
Q
-
N
D
G
--
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
S
E
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
-
R
Y
L
Q
D
-
D
T
S
D
P
----------------
V
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
-
D
Y
R
L
P
P
P
M
D
C
P
A
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
S
R
P
R
F
A
E
I
V
---
N
T
L
D
K
M
I
R
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
28.17
34%
-6
- C5 -
-
5MJA
1
B:
[18-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
A
K
E
I
D
V
S
F
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
Y
K
G
------------
R
L
K
L
P
GKREI
V
-
A
I
K
--
T
L
K
A
G
Y
S
E
K
Q
R
R
D
F
L
S
E
A
S
I
----
M
G
Q
F
D
H
R
N
I
I
R
L
E
G
V
V
--
T
-
K
S
R
P
V
M
I
I
T
E
F
M
E
N
G
A
L
D
S
F
L
R
Q
-
N
D
G
--
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
S
E
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
-
R
Y
L
Q
-------
T
-
T
S
S
LG-
G
K
I
----
P
V
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
-
D
Y
R
L
P
P
P
M
D
C
P
A
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
S
R
P
R
F
A
E
I
V
---
N
T
L
D
K
M
I
R
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
420
Blastp_CBE
23.48
34%
-6
- C5 -
-
3DK6
1
ABL1_MOUSE
B:
[8-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
F
G
E
V
Y
E
G
-
V
W
--------
K
K
Y
S
L
T
-----
V
-
A
V
K
--
T
L
K
E
D
T
-------
F
L
K
E
A
A
V
----
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
--
T
-
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
--
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-
R
L
M
T
G
-
D
T
T
A
---
H
A
G
---
A
K
F
----
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
---
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------