@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ERBB4_HUMAN: (2020-09-09 )
MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV
Atome Classification :
(396 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.....---.--.720---.-----......730.....-.-.740......-----..750.......760.......770.......780.....-.-.-790.-........800.......810.-.......820.......830.......840.......850.......860......-.-870...--...-..880........890.......900.......910.......920.......930...-....940.......950.......960.......970...---....980.......990--........1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKPA
T
G
L
W
V
W
V
S
L
L
V
AAGTVQPSDSQSVCAGTE
N
K
L
S
S
L
S
D
L
E
Q
Q
Y
R
A
L
R
K
Y
Y
E
N
C
E
V
V
MGN
L
E
I
T
S
IEHNR
D
L
S
F
L
R
S
V
R
E
V
T
G
Y
V
L
V
A
LNQFRYLPLE
N
L
R
I
I
RGTKLYED
R
Y
A
L
A
I
F
L
N
YRKDGNF
G
L
Q
E
L
G
L
K
N
L
T
E
I
LNG
G
V
Y
VDQN
K
F
L
C
Y
AD
T
I
H
W
Q
D
I
VRNPWPSN
L
T
L
V
STNGSSG
C
G
R
C
H
K
SCTGRCWGP
T
E
N
H
C
Q
T
L
T
R
T
V
C
A
E
QCDGRCYGP
Y
V
S
D
C
C
H
R
E
CAGGCSGPKDT
D
C
F
A
C
MNFNDSG
A
C
V
TQCPQ
T
F
V
YNP
T
T
F
Q
L
E
HNFNA
K
Y
T
Y
G
A
F
C
V
K
KCPH
N
F
V
VDS
S
S
C
V
R
ACPSSK
M
E
VEENG
I
K
MCK
P
C
T
D
I
C
P
K
A
CDGIGTGS
L
M
S
A
QTVDSSN
I
D
K
F
I
N
C
T
K
ING
N
L
I
F
L
V
TGIHGDPYNAIEAI
D
P
E
K
L
N
V
F
R
T
V
R
E
I
T
G
F
L
NIQSWPPNM
T
D
F
S
V
F
S
N
L
V
T
IG
G
R
V
L
Y
SGL
S
L
L
I
L
KQQGI
T
S
L
Q
F
Q
S
L
K
EISAG
N
I
Y
I
TDNS
N
L
C
Y
Y
H
TI
N
W
T
T
L
F
S
TIN
Q
R
I
V
I
RDNRKAENCTAE
G
M
V
C
N
HLCSSDGCWGP
G
P
D
Q
C
L
S
C
R
RFSRG
R
I
C
I
E
SCNLYDG
E
F
REFENG
S
I
C
V
ECDP
Q
C
E
K
MED
G
L
L
T
CHGPGPDNCTKCSHFKDG
P
N
C
V
E
KCPDGLQG
A
N
S
F
I
F
KYADPDRECHPCHPNCTQGCNGPTSH
D
C
I
Y
Y
PWTGHSTLPQHARTP
L
I
A
A
G
V
I
G
G
L
F
I
L
V
I
V
G
L
T
F
A
V
Y
V
R
R
K
S
I
K
K
K
R
A
L
R
R
F
L
E
T
E
LVEPLTPSGTAP
N
Q
A
Q
L
R
I
L
KETE---
L
--
K
R
V
K
---
V
-----LGSGA
F
G
T
V
Y
K
G
I
W-V-PE-G
E
T
V
K
I
P
-----
V
A
I
K
I
LNETTGPKA
N
V
E
F
M
D
E
A
L
I
M
ASMD
H
P
H
L
V
R
L
L
G
V
C
-
L
-
S
-
P
--
T
-
I
Q
L
V
T
Q
LMP
H
G
C
L
L
E
Y
V
H
E
-
H
K
-DNI
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
AR
N
V
L
VKSP
N
H
V
K
I
T
D
F
G
L
A
R
L
L-E-GD-EKE--YNA-DGG-KM
P
I
K
W
M
A
L
E
C
I
H
Y
R
KFTHQSD
V
W
S
Y
G
V
T
I
W
E
L
M
TFGGKPYDGIP
T
R
E
I
P
D
L
L
E
K-GERLPQPP
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
IDADSRP
K
F
K
E
L
A
A
E
F
S
---
R
MARDP
Q
R
Y
L
V
I
QGDD---RMKLPSP
N
D
S
K
F
F
Q
N
LL
D
E
E
D
L
E
D
M
M
D
A
E
E
YLVPQAFNIPPPIYT
S
R
A
RIDS
N
R
S
EIGHSPPPAYTPMSGN
Q
F
V
Y
RDGGFAAEQGVSVPYRAPTSTIPEAPVAQGA
T
A
E
IFDDSCCNGTLRKPVAPHVQEDSSTQRYSADP
T
V
FAPERSPRGELDEEGYMTPMRDK
P
K
Q
E
YLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNE
P
L
Y
L
N
T
F
A
N
T
LG
K
A
E
Y
L
K
N
N
I
LSM
P
E
K
A
K
K
AFDNPDYWNHSLPPRSTLQH
P
D
Y
L
Q
E
Y
S
T
K
Y
F
Y
KQNG
R
I
R
P
I
VAEN
P
E
Y
L
S
E
FSLKPGTVLPPPPYRHRNTVV
15
PsiBlast_PDB
65.97
100%
-153
- C5 -
-
2R4B
1
ERBB4_HUMAN
A:
[16-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
T
A
P
N
Q
A
Q
L
R
I
L
K
E
T
E
---
L
--
K
R
V
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
-
V
-
P
E
-
G
E
T
V
K
I
P
-----
V
A
I
K
I
L
N
------
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
-
L
-
S
-
P
--
T
-
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
-
H
K
-
D
N
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
-
E
-
G
D
-
E
K
E
--
Y
N
A
-
D
G
G
-
K
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
R
E
I
P
D
L
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
---
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
65.18
100%
-152
- C5 -
-
2R4B
1
B:
[16-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
T
A
P
N
Q
A
Q
L
R
I
L
K
E
T
E
---
L
--
K
R
V
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
-
V
-
P
E
-
G
E
T
V
K
I
P
-----
V
A
I
K
I
L
-------
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
-
L
-
S
-
P
--
T
-
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
-
H
K
-
D
N
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
-
E
-
G
D
-
E
K
E
--
Y
N
A
-
D
G
G
-
K
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
R
E
I
P
D
L
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
---
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Blastp_CBE
64.38
78%
-131
- C5 -
-
3W32
1
A:
[9-325]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
197
Blastp_CBE
63.96
76%
-135
- C5 -
-
5HIB
1
A:
[3-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
--------
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
----
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
194
Blastp_CBE
63.73
77%
-141
- C5 -
-
3W2O
1
A:
[7-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
----------------
M
D
D
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
63.68
100%
-160
- C5 -
-
3BBT
1
ERBB4_HUMAN
B:
[7-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
L
R
I
L
K
E
T
E
---
L
--
K
R
V
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
-
V
-
P
E
-
G
E
T
V
K
I
P
-----
V
A
I
K
I
L
N
E
--
G
P
K
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
-
L
-
S
-
P
--
T
-
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
-
H
K
-
D
N
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
---------------------
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
R
E
I
P
D
L
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
---
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
-
D
D
---
R
M
K
L
P
S
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
63.37
78%
-145
- C5 -
-
3W2S
1
A:
[9-327]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
63.28
76%
-145
- C5 -
-
5CAN
1
A:
[3-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
-------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
63.15
77%
-139
- C5 -
-
3W2P
1
A:
[7-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
--------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
63.14
76%
-146
- C5 -
-
5CAO
1
A:
[4-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
---
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-----------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
----
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
63.13
77%
-134
- C5 -
-
6S8A
2
?
A:
[8-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
S
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
A
-
A
A
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
------------
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
62.83
78%
-135
- C5 -
-
5UGB
1
A:
[2-325]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
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D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
---------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
62.77
78%
-141
- C5 -
-
4JR3
1
A:
[3-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
------------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
62.71
76%
-148
- C5 -
-
5EDR
1
A:
[4-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-----------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
-----
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
62.70
76%
-144
- C5 -
-
5C8N
1
A:
[3-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
---
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
-------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
62.67
77%
-149
- C5 -
-
3VJN
1
A:
[9-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
S
S
---
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
-
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
------------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Blastp_CBE
62.67
76%
-146
- C5 -
-
4RIX
1
EGFR_HUMAN
B:
[11-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
192
Blastp_CBE
62.65
77%
-140
- C5 -
-
3W2Q
2
A:
[7-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
--------------
M
D
D
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
62.61
78%
-133
- C5 -
-
5X2K
1
A:
[1-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
----------
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
---
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
208
Blastp_CBE
62.52
76%
-144
- C5 -
-
5CAQ
1
A:
[4-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
-----
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
62.50
78%
-141
- C5 -
-
5Y9T
1
A:
[8-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
--
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
-------------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
62.46
76%
-148
- C5 -
-
4RJ8
1
A:
[4-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
----
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
------
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
62.43
76%
-148
- C5 -
-
5HCX
1
A:
[3-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
---
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
--------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
219
Blastp_CBE
62.34
76%
-153
- C5 -
-
4RJ5
1
A:
[4-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
----
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-----------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
-------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
Blastp_CBE
62.35
78%
-144
- C5 -
-
2ITN
1
A:
[1-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
S
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
-------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
-----------
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
62.35
100%
-165
- C5 -
-
3BBT
1
D:
[8-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
R
I
L
K
E
T
E
---
L
--
K
R
V
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
-
V
-
P
---
E
T
V
K
I
P
-----
V
A
I
K
I
L
N
E
---
P
K
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
-
L
-
S
-
P
--
T
-
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
-
H
K
-
D
N
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
-----------------------
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
R
E
I
P
D
L
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
---
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
202
Blastp_CBE
62.34
76%
-145
- C5 -
-
5EM6
1
A:
[4-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
---
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
-----
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
62.32
76%
-141
- C5 -
-
4RIX
1
D:
[11-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
62.28
78%
-141
- C5 -
-
4JQ8
1
A:
[3-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
------------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
62.27
76%
-140
- C5 -
-
5HIC
1
A:
[4-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
-----
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
218
Blastp_CBE
62.24
76%
-146
- C5 -
-
4RJ6
1
A:
[4-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
----
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
-------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
62.24
78%
-146
- C5 -
-
3W33
1
A:
[9-326]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
-----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
----
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
62.23
76%
-141
- C5 -
-
4RIW
1
EGFR_HUMAN
B:
[11-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
209
Blastp_CBE
62.19
76%
-143
- C5 -
-
5CAP
1
A:
[4-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
----------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
-----
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
62.19
76%
-142
- C5 -
-
5HCZ
1
A:
[3-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
---
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
-------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
62.15
78%
-143
- C5 -
-
4JRV
1
A:
[3-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
---
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
------------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
62.11
78%
-136
- C5 -
-
5XDK
1
A:
[5-327]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
-
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
---------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
62.08
76%
-143
- C5 -
-
5C8M
1
A:
[4-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
-----
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
203
Blastp_CBE
62.07
76%
-147
- C5 -
-
5EM5
1
A:
[4-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
----
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-----------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
-----
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
62.04
78%
-129
- C5 -
-
2GS6
1
A:
[4-327]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
---
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
-------------
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
61.99
78%
-143
- C5 -
-
2ITV
1
A:
[1-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-
G
-
A
E
-
E
-------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
------------
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
61.98
77%
-131
- C5 -
-
5HG8
2
A:
[7-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
61.97
76%
-143
- C5 -
-
5EM7
1
A:
[3-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
---
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
-------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
61.96
78%
-141
- C5 -
-
2ITZ
1
A:
[2-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-
G
-
A
E
---------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
-----------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
240
Blastp_CBE
61.94
77%
-142
- C5 -
-
6S9C
2
?
A:
[3-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
--
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
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D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
-----------
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Blastp_CBE
61.91
78%
-132
- C5 -
-
4I23
1
A:
[2-325]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
---
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
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G
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P
A
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I
S
S
I
L
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-
G
E
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L
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P
P
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D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
---------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
61.88
77%
-131
- C5 -
-
4ZSE
1
EGFR_HUMAN
B:
[7-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
61.87
76%
-145
- C5 -
-
5HCY
1
A:
[3-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
--------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
-------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
61.88
76%
-143
- C5 -
-
4RIY
1
EGFR_HUMAN
B:
[11-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
61.87
77%
-138
- C5 -
-
4WD5
1
EGFR_HUMAN
A:
[3-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
---------------------
D
V
V
D
A
D
E
Y
L
I
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
61.82
78%
-137
- C5 -
-
5X27
1
A:
[2-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-
G
-
A
E
-
E
-------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
-------------
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
61.81
78%
-144
- C5 -
-
3GT8
1
EGFR_HUMAN
C:
[7-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
--------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
61.80
78%
-135
- C5 -
-
5X28
1
A:
[2-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-
G
-
A
E
-
E
-------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
-----
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
61.80
78%
-129
- C5 -
-
5CAV
1
A:
[4-327]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
---------------------
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
61.78
78%
-148
- C5 -
-
3POZ
1
A:
[6-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
-----
V
K
I
P
-----
V
A
I
K
E
L
-------
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
-----------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
------
D
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
61.78
78%
-136
- C5 -
-
5EM8
1
A:
[3-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
---
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
---
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
---------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
61.75
77%
-134
- C5 -
-
6S89
2
?
A:
[8-328]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
S
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
A
-
A
A
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
--------------
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
61.77
76%
-143
- C5 -
-
5EDQ
1
A:
[4-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-----------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
--------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
220
Blastp_CBE
61.75
76%
-144
- C5 -
-
4RJ4
1
A:
[4-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
---
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
------
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
61.74
78%
-134
- C5 -
-
2ITW
1
A:
[1-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
-------------------------
D
M
D
D
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
61.70
76%
-138
- C5 -
-
4RIW
1
D:
[11-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Blastp_CBE
61.68
78%
-140
- C5 -
-
4G5P
1
EGFR_HUMAN
A:
[4-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
----------------------
D
V
V
D
A
D
E
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
61.64
78%
-139
- C5 -
-
6JZ0
1
?
A:
[1-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
-
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
------------
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
61.59
77%
-145
- C5 -
-
3W2R
2
A:
[7-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
------------
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Blastp_CBE
61.58
78%
-146
- C5 -
-
2EB3
1
A:
[8-330]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
-
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
--------------
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
61.56
78%
-139
- C5 -
-
2ITU
1
A:
[1-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-
G
-
A
E
---------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
----------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Blastp_CBE
61.55
77%
-137
- C5 -
-
4LQM
1
A:
[6-328]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
---
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-
G
-
A
E
-
E
----------
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
--------
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
61.53
76%
-143
- C5 -
-
5C8K
1
A:
[4-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
----------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
-----
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
61.52
78%
-138
- C5 -
-
4WKQ
2
A:
[4-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
---
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
-----
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
-
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
-------------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
61.53
78%
-142
- C5 -
-
2ITT
1
A:
[2-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-
G
-
A
E
-
E
-------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
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F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
------------
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
61.51
77%
-132
- C5 -
-
5HG5
2
A:
[7-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
Blastp_CBE
61.52
78%
-126
- C5 -
-
5GTZ
4
A:
[6-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
-----------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
61.51
78%
-134
- C5 -
-
4JQ7
1
A:
[3-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
------------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
206
Blastp_CBE
61.48
76%
-148
- C5 -
-
5CAU
1
A:
[3-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
----
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
--------
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
61.48
78%
-137
- C5 -
-
5X26
1
A:
[2-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-
G
-
A
E
-
E
-------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
-------------
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
207
Blastp_CBE
61.46
76%
-145
- C5 -
-
5CAS
1
A:
[3-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
----
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
--------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
--------
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
61.46
77%
-145
- C5 -
-
3UG2
2
A:
[9-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
S
S
---
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
-----
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
---------------
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
61.44
77%
-124
- C5 -
-
5X2F
1
EGFR_HUMAN
B:
[8-319]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
61.36
76%
-147
- C5 -
-
4RJ7
1
A:
[4-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
-----
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
--------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
161
Blastp_CBE
61.30
77%
-141
- C5 -
-
4ZSE
2
EGFR_HUMAN
A:
[8-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
61.25
78%
-134
- C5 -
-
6D8E
1
A:
[1-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
----
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
----
E
--
Y
H
A
-
E
---
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
-----
M
H
L
P
S
---------
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
61.24
76%
-142
- C5 -
-
5CAL
1
A:
[4-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
----------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
-----
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
61.19
78%
-130
- C5 -
-
2J5F
1
A:
[1-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
--------
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
61.18
77%
-140
- C5 -
-
5U8L
2
A:
[9-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
Blastp_CBE
61.12
78%
-134
- C5 -
-
2ITP
1
A:
[2-323]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
S
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
--------------------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
Blastp_CBE
61.11
78%
-138
- C5 -
-
5YU9
1
EGFR_HUMAN
C:
[6-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
---
V
D
A
D
E
Y
L
I
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
61.07
76%
-131
- C5 -
-
4RIY
1
D:
[11-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
61.00
77%
-140
- C5 -
-
6S9D
2
?
A:
[3-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
--
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-----------------
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
-----------
D
M
D
D
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
60.99
77%
-134
- C5 -
-
6P1D
1
?
A:
[5-325]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
--------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
159
Blastp_CBE
60.99
77%
-137
- C5 -
-
4ZSE
2
EGFR_HUMAN
C:
[9-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
--------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
Blastp_CBE
60.97
78%
-136
- C5 -
-
2ITQ
1
A:
[2-323]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
S
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
-------------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
164
Blastp_CBE
60.96
77%
-141
- C5 -
-
5ZTO
1
A:
[6-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
S
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
------------------------
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
--------
M
D
D
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
60.96
77%
-125
- C5 -
-
5X2F
1
D:
[6-323]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
-----------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
--
D
D
V
V
D
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
60.93
78%
-132
- C5 -
-
2ITX
1
A:
[2-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
-------
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
------------
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
60.90
78%
-149
- C5 -
-
5FEQ
1
A:
[3-323]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
-----
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
----
E
--
Y
H
A
---
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
------------------------
M
D
D
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
60.83
78%
-143
- C5 -
-
5XGM
1
A:
[5-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
-
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
---
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
-----------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
-
L
P
---------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
60.78
77%
-135
- C5 -
-
5X2F
1
EGFR_HUMAN
C:
[9-323]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
--------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
60.75
78%
-136
- C5 -
-
5GMP
1
A:
[5-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
----------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
--------
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
60.74
78%
-131
- C5 -
-
3VJO
1
A:
[8-330]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
--
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
---
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
-----------------------
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
60.71
77%
-135
- C5 -
-
5XGN
1
EGFR_HUMAN
A:
[6-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
S
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
----------------------
V
D
A
D
E
Y
L
I
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
60.69
78%
-144
- C5 -
-
2GS7
1
B:
[9-324]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-----
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
----------------------------
D
V
V
D
A
D
E
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
60.68
78%
-128
- C5 -
-
2J6M
1
A:
[2-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
---------------------
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
60.67
77%
-138
- C5 -
-
5X2C
6
EGFR_HUMAN
A:
[9-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
Blastp_CBE
60.66
78%
-135
- C5 -
-
2ITO
1
A:
[1-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
S
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
-------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
------------
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
60.63
78%
-141
- C5 -
-
2ITY
1
A:
[2-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
---------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
-------------
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
60.60
78%
-152
- C5 -
-
2RGP
1
A:
[1-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
-----
V
K
I
P
-----
V
A
I
K
E
L
R
-----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
--------
N
F
Y
R
A
L
M
------
D
V
V
D
A
D
E
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
60.57
78%
-151
- C5 -
-
1XKK
1
A:
[32-348]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
-----
V
K
I
P
-----
V
A
I
K
E
L
R
E
----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
-------
S
N
F
Y
R
A
L
M
D
E
-----
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
60.55
77%
-137
- C5 -
-
5X2F
1
EGFR_HUMAN
A:
[9-323]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
--
V
V
D
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
60.55
78%
-134
- C5 -
-
5CNO
1
EGFR_HUMAN
B:
[6-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
60.53
78%
-143
- C5 -
-
5YU9
2
EGFR_HUMAN
B:
[8-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
-----
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
--------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
60.50
78%
-144
- C5 -
-
5J9Z
1
A:
[1-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
----------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
-------------------
M
D
D
V
V
D
A
D
E
Y
L
I
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
60.49
78%
-138
- C5 -
-
5J9Y
1
A:
[2-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
------
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
-----------------------
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
60.46
78%
-146
- C5 -
-
5FED
1
A:
[3-323]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
---
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
-----
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-------
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
------------------------
M
D
D
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
60.43
78%
-126
- C5 -
-
4LI5
1
A:
[4-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
-------------------------
D
D
V
V
D
A
D
E
Y
L
I
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
60.40
77%
-149
- C5 -
-
5Y25
1
A:
[8-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
---
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
-----------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
----------
D
D
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
180
Blastp_CBE
60.37
77%
-144
- C5 -
-
5UGC
5
A:
[9-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
----
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Blastp_CBE
60.31
75%
-131
- C5 -
-
5CNN
1
B:
[8-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
Q
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-----------------
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
183
Blastp_CBE
60.28
77%
-146
- C5 -
-
5UG8
5
A:
[9-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
----
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
60.28
78%
-132
- C5 -
-
5YU9
1
EGFR_HUMAN
A:
[9-326]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
60.27
77%
-139
- C5 -
-
6P1L
1
?
B:
[7-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
----------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
60.21
77%
-141
- C5 -
-
5HG9
4
A:
[9-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
----
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
60.18
78%
-135
- C5 -
-
5YU9
1
D:
[9-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
--------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
60.17
77%
-130
- C5 -
-
5X2C
8
B:
[10-323]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-----------------
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
224
Blastp_CBE
60.11
75%
-136
- C5 -
-
3PP0
1
ERBB2_HUMAN
A:
[5-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
L
--
R
K
V
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
-
I
-
P
D
-
G
E
N
V
K
I
P
-----
V
A
I
K
V
L
R
E
N
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
-
N
R
-
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
-
D
-
I
D
-
E
T
E
--
Y
H
A
---
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
---
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
182
Blastp_CBE
60.10
77%
-143
- C5 -
-
5UG9
5
A:
[9-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
----
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
60.06
77%
-135
- C5 -
-
4R5S
1
A:
[6-327]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-
G
-
A
E
-
E
-------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
--------------
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
60.02
77%
-140
- C5 -
-
5UGA
4
A:
[10-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
60.00
78%
-140
- C5 -
-
4HJO
1
A:
[18-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
-----
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
60.00
78%
-125
- C5 -
-
4G5J
3
A:
[4-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
----
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
----------
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
156
Blastp_CBE
59.99
77%
-134
- C5 -
-
5D41
1
B:
[10-323]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
59.96
77%
-139
- C5 -
-
5XDL
1
A:
[5-327]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
--
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
----------------------
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
--------------
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
59.95
77%
-136
- C5 -
-
4ZSE
1
D:
[10-324]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
--
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
----
V
V
D
A
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
59.91
79%
-144
- C5 -
-
5GNK
15
A:
[6-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
59.88
78%
-138
- C5 -
-
3GT8
1
D:
[9-318]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
----------------------
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
59.86
75%
-131
- C5 -
-
3PP0
1
B:
[5-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
L
--
R
K
V
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
-
I
-
P
D
-
G
E
N
V
K
I
P
-----
V
A
I
K
V
L
R
E
N
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
-
N
R
-
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
-
D
-
I
D
-
E
T
E
--
Y
H
A
---
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
---
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
----------
P
L
D
S
T
F
Y
R
S
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
59.74
80%
-154
- C5 -
-
3LZB
1
EGFR_HUMAN
A:
[8-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
-----------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
59.69
80%
-153
- C5 -
-
3LZB
1
EGFR_HUMAN
B:
[8-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
-----------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
59.67
78%
-152
- C5 -
-
3BEL
1
A:
[1-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
-----
V
K
I
P
-----
V
A
I
K
E
L
------
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
---------
N
F
Y
R
A
L
M
-------
V
V
D
A
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
59.58
78%
-139
- C5 -
-
3GT8
1
EGFR_HUMAN
B:
[9-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
----------------------
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
Blastp_CBE
59.57
75%
-130
- C5 -
-
5CNN
1
EGFR_HUMAN
A:
[7-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
L
L
R
Q
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
---
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
--------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
59.53
78%
-149
- C5 -
-
5FEE
1
A:
[3-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
----
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
-----
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
--------
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
------------------------
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
59.52
78%
-131
- C5 -
-
5JEB
1
A:
[14-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
--
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
59.52
78%
-141
- C5 -
-
2GS7
1
EGFR_HUMAN
A:
[11-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
----------------------------
D
V
V
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
59.47
77%
-139
- C5 -
-
5HG7
1
A:
[9-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
---
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-
G
-
A
E
-
E
K
E
--
Y
H
A
-
E
G
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
59.41
78%
-135
- C5 -
-
5CNO
1
EGFR_HUMAN
A:
[8-323]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
-----
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-----------------
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
59.37
63%
-150
- C5 -
-
6OP9
1
A:
[26-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
R
I
F
K
E
T
E
---
L
--
R
K
L
K
---
V
-----
L
G
S
G
V
F
G
T
V
H
K
G
V
W
-
I
-
P
E
-
G
E
S
I
K
I
P
-----
V
C
I
K
V
I
E
D
K
S
G
R
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
-
P
-
G
-
S
--
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
R
-
G
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
-
P
-
P
D
-
D
K
Q
--------
A
-
K
T
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
-
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
---
R
M
A
R
D
P
P
R
Y
L
V
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
59.37
77%
-137
- C5 -
-
6S9B
1
?
A:
[2-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
---
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
-----------------
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
59.35
78%
-138
- C5 -
-
4I24
1
EGFR_HUMAN
A:
[7-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
-------
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
--------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
189
Blastp_CBE
59.32
77%
-137
- C5 -
-
4I22
1
A:
[7-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
-----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
--------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
59.17
77%
-151
- C5 -
-
5ZWJ
1
A:
[29-312]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
S
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
------------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
Blastp_CBE
59.09
78%
-132
- C5 -
-
4I24
1
B:
[7-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-----------------
G
-
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
58.92
78%
-140
- C5 -
-
4ZAU
1
A:
[6-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
---------
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
------
E
K
E
--
Y
H
A
-
E
---
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
--------------------------
D
D
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
58.81
78%
-130
- C5 -
-
3GT8
1
EGFR_HUMAN
A:
[8-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
----------------------
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
58.44
77%
-143
- C5 -
-
4LL0
1
B:
[7-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
---------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
----------------------------
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
58.41
80%
-150
- C5 -
-
3LZB
1
EGFR_HUMAN
D:
[8-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
-----------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
179
Blastp_CBE
58.25
77%
-150
- C5 -
-
5UWD
1
A:
[9-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
58.02
63%
-153
- C5 -
-
3LMG
1
ERBB3_HUMAN
A:
[23-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
R
I
F
K
E
T
E
---
L
--
R
K
L
K
---
V
-----
L
G
S
G
V
F
G
T
V
H
K
G
V
W
-
I
-
P
E
-
G
E
S
I
K
I
P
-----
V
C
I
K
V
I
E
D
K
---
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
-
P
-
G
-
S
--
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
R
-
G
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
-
P
-
P
D
-
D
-------------
T
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
-
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
---
R
M
A
R
D
P
P
R
Y
L
V
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
281
Blastp_CBE
57.97
64%
-153
- C5 -
-
4RIY
1
C:
[8-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
F
K
E
T
E
---
L
--
R
K
L
K
---
V
-----
L
G
S
G
V
F
G
T
V
H
K
G
V
W
-
I
-
P
E
-
G
E
S
I
K
I
P
-----
V
C
I
K
V
I
E
------
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
-
P
-
G
-
S
--
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
R
-
G
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
-
P
-
P
D
-
D
K
Q
--
L
L
Y
-
S
E
A
-
K
T
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
-
G
G
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
---
R
M
A
R
D
P
P
R
Y
L
V
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
57.95
63%
-156
- C5 -
-
3LMG
1
B:
[23-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
R
I
F
K
E
T
E
---
L
--
R
K
L
K
---
V
-----
L
G
S
G
V
F
G
T
V
H
K
G
V
W
-
I
-
P
--
G
E
S
I
K
I
P
-----
V
C
I
K
V
I
E
D
K
S
--
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
-
P
-
G
-
S
--
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
R
-
G
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
-
P
-
P
D
-
D
K
-------------
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
-
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
---
R
M
A
R
D
P
P
R
Y
L
V
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
57.89
64%
-158
- C5 -
-
4RIY
1
ERBB3_HUMAN
A:
[8-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
F
K
E
T
E
---
L
--
R
K
L
K
---
V
-----
L
G
S
G
V
F
G
T
V
H
K
G
V
W
-
I
-
P
E
-
G
E
S
I
K
I
P
-----
V
C
I
K
V
I
E
D
K
S
G
R
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
-
P
-
G
-
S
--
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
R
-
G
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
-
P
-
P
-----------------
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
-
G
G
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
---
R
M
A
R
D
P
P
R
Y
L
V
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
279
Blastp_CBE
57.83
64%
-152
- C5 -
-
4RIX
1
C:
[8-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
F
K
E
T
E
---
L
--
R
K
L
K
---
V
-----
L
G
S
G
V
F
G
T
V
H
K
G
V
W
-
I
-
P
E
-
G
E
S
I
K
I
P
-----
V
C
I
K
V
I
E
------
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
-
P
-
G
-
S
--
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
R
-
G
A
L
G
P
R
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
-
P
-
P
D
-
D
K
Q
--
L
L
Y
-
S
E
A
-
K
T
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
-
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
---
R
M
A
R
D
P
P
R
Y
L
V
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
57.62
77%
-132
- C5 -
-
4LL0
1
EGFR_HUMAN
A:
[6-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
--------------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---
R
M
----------------
E
E
D
M
-
D
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
57.53
64%
-154
- C5 -
-
3KEX
1
ERBB3_HUMAN
A:
[8-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
F
K
E
T
E
---
L
--
R
K
L
K
---
V
-----
L
G
S
G
V
F
G
T
V
H
K
G
V
W
-
I
-
P
E
-
G
E
S
I
K
I
P
-----
V
C
I
K
V
I
E
D
K
S
G
R
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
-
P
-
G
-
S
--
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
R
-
G
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
-
P
-
P
D
-
D
K
Q
--
L
L
-------
T
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
-
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
---
R
M
A
R
D
P
P
R
Y
L
V
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
57.48
80%
-150
- C5 -
-
3LZB
1
EGFR_HUMAN
C:
[9-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
I
L
K
E
T
E
---
F
--
K
K
I
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
-
I
-
P
E
-
G
E
K
V
K
I
P
-----
V
A
I
K
E
L
R
E
-----
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
K
-
D
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
-----------------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
275
Blastp_CBE
57.36
64%
-150
- C5 -
-
4RIW
1
C:
[8-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
F
K
E
T
E
---
L
--
R
K
L
K
---
V
-----
L
G
S
G
V
F
G
T
V
H
K
G
V
W
-
I
-
P
E
-
G
E
S
I
K
I
P
-----
V
C
I
K
V
I
E
------
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
-
P
-
G
-
S
--
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
R
-
G
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
-
P
-
P
D
-
D
K
Q
--
L
L
Y
-
S
E
A
-
K
T
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
-
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
---
R
M
A
R
D
P
P
R
Y
L
V
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
277
Blastp_CBE
57.12
64%
-152
- C5 -
-
3KEX
1
B:
[8-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
F
K
E
T
E
---
L
--
R
K
L
K
---
V
-----
L
G
S
G
V
F
G
T
V
H
K
G
V
W
-
I
-
P
E
-
G
E
S
I
K
I
P
-----
V
C
I
K
V
I
E
D
K
S
G
R
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
-
P
-
G
-
S
--
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
R
-
G
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
-
P
-
P
D
-
D
K
Q
-----------
T
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
-
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
---
R
M
A
R
D
P
P
R
Y
L
V
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
276
Blastp_CBE
56.97
64%
-155
- C5 -
-
4RIW
1
ERBB3_HUMAN
A:
[8-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
F
K
E
T
E
---
L
--
R
K
L
K
---
V
-----
L
G
S
G
V
F
G
T
V
H
K
G
V
W
-
I
-
P
E
-
G
E
S
I
K
I
P
-----
V
C
I
K
V
I
E
D
K
S
G
R
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
-
P
-
G
-
S
--
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
R
-
G
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
-
P
-
P
-----------------
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
-
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
---
R
M
A
R
D
P
P
R
Y
L
V
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
56.75
75%
-135
- C5 -
-
3RCD
1
ERBB2_HUMAN
C:
[9-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
---
L
--
R
K
V
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
-
I
-
P
D
-
G
E
N
V
K
I
P
-----
V
A
I
K
V
L
R
----
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
-
N
R
-
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
------------------------
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
---
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
------------
L
D
S
T
F
Y
R
S
L
L
E
D
D
---
D
L
V
D
A
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
280
Blastp_CBE
56.74
64%
-153
- C5 -
-
4RIX
1
ERBB3_HUMAN
A:
[8-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
F
K
E
T
E
---
L
--
R
K
L
K
---
V
-----
L
G
S
G
V
F
G
T
V
H
K
G
V
W
-
I
-
P
E
-
G
E
S
I
K
I
P
-----
V
C
I
K
V
I
E
D
K
S
G
R
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
-
P
-
G
-
S
--
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
R
-
G
A
L
G
P
R
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
-
P
-
P
-----------------
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
-
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
---
R
M
A
R
D
P
P
R
Y
L
V
I
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
56.72
75%
-136
- C5 -
-
3RCD
1
ERBB2_HUMAN
A:
[9-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
---
L
--
R
K
V
K
---
V
-----
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
-
I
-
P
D
-
G
E
N
V
K
I
P
-----
V
A
I
K
V
L
R
----
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
-
L
-
T
-
S
--
T
-
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
-
N
R
-
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
------------------------
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
-
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
---
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
------------
L
D
S
T
F
Y
R
S
L
L
E
D
D
---
D
L
V
D
A
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
403
Blastp_CBE
49.19
41%
-158
- C5 -
-
5TOB
1
A:
[19-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
I
-----
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
-
T
-
H
K
-
G
E
--
K
I
N
-----
V
A
V
K
T
C
K
-----
D
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
-----
E
--
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
-
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
--------------------------
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
DVY
Q
M
E
K
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
395
Blastp_CBE
43.51
39%
-62
- C5 -
-
4H1J
1
A:
[20-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
A
R
E
D
---
V
--
V
L
N
R
---
I
-----
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
-
T
N
H
K
-
G
E
--
K
I
N
-----
V
A
V
K
T
C
K
K
D
C
T
L
D
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
-
E
-
E
-
E
--
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
-
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
R
---------------
A
-
S
V
T
-
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
DVY
Q
M
E
K
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
42.74
40%
-52
- C5 -
-
2F4J
1
ABL1_HUMAN
A:
[1-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
----
Y
T
A
P
A
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
42.69
41%
-62
- C5 -
-
2G2I
1
ABL1_HUMAN
B:
[12-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
----
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
----
Y
T
A
P
A
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
42.66
39%
-66
- C5 -
-
4H1M
1
A:
[21-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
E
D
---
V
--
V
L
N
R
---
I
-----
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
-
T
N
H
K
-
G
E
--
K
I
N
-----
V
A
V
K
T
C
K
K
D
C
T
L
D
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
-
E
-
E
-
E
--
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
-
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
-----------------------
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
DVY
Q
M
E
K
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
508
Blastp_CBE
42.43
41%
-54
- C5 -
-
2G2F
1
ABL1_HUMAN
A:
[12-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
----
Y
T
A
P
A
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
506
Blastp_CBE
42.20
41%
-48
- C5 -
-
2G2H
1
ABL1_HUMAN
A:
[12-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
----
Y
T
A
P
A
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
41.95
41%
-54
- C5 -
-
2G2H
1
ABL1_HUMAN
B:
[12-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
----
Y
T
A
P
A
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
399
Blastp_CBE
41.86
41%
-66
- C5 -
-
3FZR
1
A:
[14-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
I
-----
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
-
T
N
H
K
-
G
E
--
K
I
N
-----
V
A
V
K
T
C
K
K
D
C
T
L
D
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
-
E
-
E
-
E
--
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
-
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
R
-------------------
T
-
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
DVY
Q
M
E
K
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
41.74
41%
-56
- C5 -
-
2G2I
1
ABL1_HUMAN
A:
[12-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
---
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
----
Y
T
A
P
A
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
450
Blastp_CBE
41.74
40%
-36
- C5 -
-
1M52
1
ABL1_MOUSE
A:
[10-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
449
Blastp_CBE
41.73
40%
-39
- C5 -
-
1M52
3
ABL1_MOUSE
B:
[10-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
529
Blastp_CBE
41.65
41%
-58
- C5 -
-
3EQP
1
ACK1_HUMAN
A:
[4-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
E
K
D
---
L
--
R
L
L
E
---
K
-----
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
-
P
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
------
Q
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
-
T
-
P
--
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
-
G
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
-
N
D
-
D
H
Y
--
V
M
Q
-
E
H
R
-
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
41.62
41%
-64
- C5 -
-
3FZT
1
A:
[14-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
I
-----
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
-
T
N
H
K
-
G
E
--
K
I
N
-----
V
A
V
K
T
C
K
K
D
C
T
L
D
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
-
E
-
E
-
E
--
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
-
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
R
-------------------
T
-
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
DVY
Q
M
E
K
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
41.40
41%
-69
- C5 -
-
3H3C
1
A:
[14-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
I
-----
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
-
T
N
H
K
-
G
E
--
K
I
N
-----
V
A
V
K
T
C
K
K
D
C
T
L
D
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
-
E
-
E
-
E
--
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
-
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
---------------------
T
-
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
DVY
Q
M
E
K
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
41.34
40%
-62
- C5 -
-
1U4D
1
ACK1_HUMAN
B:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
C
L
I
G
E
K
D
---
L
--
R
L
L
E
---
K
-----
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
-
P
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
---------
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
-
T
-
P
--
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
----
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
-
N
D
-
D
H
Y
--
V
M
Q
-
E
H
R
-
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
528
Blastp_CBE
41.27
41%
-58
- C5 -
-
3EQP
1
ACK1_HUMAN
B:
[4-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
E
K
D
---
L
--
R
L
L
E
---
K
-----
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
-
P
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
------
Q
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
-
T
-
P
--
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
-
G
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
-
N
D
-
D
H
Y
--
V
M
Q
-
E
H
R
-
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
398
Blastp_CBE
41.32
41%
-65
- C5 -
-
3FZS
1
A:
[14-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
I
-----
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
-
T
N
H
K
-
G
E
--
K
I
N
-----
V
A
V
K
T
C
K
K
D
C
T
L
D
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
-
E
-
E
-
E
--
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
-
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
-------------------------
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
DVY
Q
M
E
K
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
407
Blastp_CBE
41.27
40%
-37
- C5 -
-
4WA9
1
ABL1_HUMAN
B:
[7-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
401
Blastp_CBE
41.13
41%
-65
- C5 -
-
3ET7
1
A:
[14-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
I
-----
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
-
T
N
H
K
-
G
E
--
K
I
N
-----
V
A
V
K
T
C
K
K
D
C
T
L
D
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
-
E
-
E
-
E
--
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
-
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
R
-------------------
T
-
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
DVY
Q
M
E
K
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
41.11
43%
-43
- C5 -
-
2XYN
2
ABL2_HUMAN
A:
[29-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
--
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
-
E
-
P
--
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
-
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
---
T
M
F
H
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
41.10
40%
-34
- C5 -
-
1OPJ
2
ABL1_MOUSE
B:
[6-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
41.07
40%
-58
- C5 -
-
1U54
1
ACK1_HUMAN
B:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
C
L
I
G
E
K
D
---
L
--
R
L
L
E
---
K
-----
L
G
D
---
G
V
V
R
R
G
E
W
D
A
-
P
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
--------
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
-
T
-
P
--
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
-
G
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
-
N
D
-
D
H
Y
--
V
M
Q
-
E
H
R
-
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
420
Blastp_CBE
40.97
40%
-32
- C5 -
-
3QRI
1
ABL1_HUMAN
A:
[6-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
40.96
43%
-39
- C5 -
-
4XLI
1
B:
[5-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
----
G
E
V
Y
V
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
-
E
-
P
--
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
S
R
-
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
-
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
---
T
M
F
H
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
283
Blastp_CBE
40.87
40%
-26
- C5 -
-
5WNO
1
A:
[15-326]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
L
I
P
S
S
E
---
L
QT
K
L
D
K
---
K
-----
L
G
A
G
A
F
G
T
V
F
A
G
I
Y
-
Y
-
P
K
R
A
-
N
V
K
I
P
-----
V
A
I
K
V
F
Q
--
T
D
Q
S
Q
T
D
E
M
L
E
E
A
T
N
M
F
R
L
R
H
D
N
L
L
K
I
I
G
F
C
-
M
-
H
-
D
--
D
G
L
K
I
V
T
I
Y
R
P
L
G
N
L
Q
N
F
L
K
L
-
H
K
-
E
N
L
G
A
R
E
Q
V
L
Y
C
Y
Q
I
A
S
G
M
Q
Y
L
E
K
Q
R
V
V
H
R
D
L
A
T
R
N
V
L
V
K
K
F
N
H
V
E
I
T
D
F
G
L
S
K
I
L
-------------------
K
V
A
I
K
W
L
A
I
E
I
F
S
K
H
C
Y
T
H
A
S
D
V
W
A
F
G
V
T
C
W
E
I
I
T
F
G
Q
S
P
Y
Q
G
M
S
T
D
S
I
H
N
F
L
K
D
-
G
N
R
L
S
Q
P
P
N
C
S
Q
D
L
Y
Q
E
L
L
R
C
W
M
A
D
P
K
S
R
P
G
F
E
I
L
Y
E
R
F
K
---
E
F
C
K
V
P
Q
--
L
F
L
E
N
S
N
---
K
I
S
E
S
D
L
S
A
E
E
R
F
Q
T
----
E
R
I
R
E
M
F
D
G
---------
N
I
D
P
Q
M
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
400
Blastp_CBE
40.86
41%
-61
- C5 -
-
3FZP
1
A:
[14-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
I
-----
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
-
T
N
H
K
-
G
E
--
K
I
N
-----
V
A
V
K
T
C
K
K
D
C
T
L
D
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
-
E
-
E
-
E
--
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
-
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
----------------------
T
-
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
DVY
Q
M
E
K
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
40.83
41%
-53
- C5 -
-
3EQR
1
ACK1_HUMAN
A:
[4-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
E
K
D
---
L
--
R
L
L
E
---
K
-----
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
-
P
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
K
------
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
-
T
-
P
--
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
-
G
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
-
N
D
-
D
H
Y
--
V
M
Q
-
E
H
R
-
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
40.82
40%
-34
- C5 -
-
6HD4
2
ABL1_MOUSE
B:
[6-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
---
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
40.80
43%
-37
- C5 -
-
3HMI
1
ABL2_HUMAN
A:
[29-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
-
E
-
P
--
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
-
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
---
T
M
F
H
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
40.77
40%
-27
- C5 -
-
2G1T
1
ABL1_HUMAN
C:
[12-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
435
Blastp_CBE
40.75
40%
-36
- C5 -
-
6HD6
2
ABL1_MOUSE
A:
[6-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
--
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
40.72
40%
-33
- C5 -
-
1IEP
1
ABL1_MOUSE
A:
[6-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
40.61
40%
-36
- C5 -
-
3K5V
2
ABL1_MOUSE
A:
[6-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
-
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
418
Blastp_CBE
40.64
40%
-34
- C5 -
-
3QRK
1
ABL1_HUMAN
A:
[6-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
40.61
40%
-62
- C5 -
-
1U4D
1
ACK1_HUMAN
A:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
C
L
I
G
E
K
D
---
L
--
R
L
L
E
---
K
-----
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
-
P
S
-
G
K
T
V
S
V
A
-----
V
K
C
--------
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
-
T
-
P
--
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
-
G
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
----
D
H
Y
--
V
M
-------
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
493
Blastp_CBE
40.55
39%
-56
- C5 -
-
2GQG
2
ABL1_HUMAN
A:
[6-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
T
A
--
H
A
---
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
516
Blastp_CBE
40.51
40%
-43
- C5 -
-
4TWP
1
ABL1_HUMAN
B:
[5-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
467
Blastp_CBE
40.48
40%
-33
- C5 -
-
4XEY
1
ABL1_HUMAN
A:
[116-384]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
----
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
40.44
40%
-33
- C5 -
-
5HU9
14
ABL1_HUMAN
A:
[4-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
----------------
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
40.44
39%
-43
- C5 -
-
4GU9
1
B:
[8-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
--
S
-
P
--
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
40.42
40%
-31
- C5 -
-
1OPJ
2
ABL1_MOUSE
A:
[6-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
496
Blastp_CBE
40.40
38%
-37
- C5 -
-
6FNJ
2
B:
[12-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
---
V
--
S
Y
V
K
IEE
V
-----
I
G
A
G
E
F
G
E
V
C
R
G
R
L
-
K
-
A
P
-
G
K
K
E
S
C
------
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
-
T
N
S
-
M
--
P
-
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
D
-
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
------------------------
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
-
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
---
K
M
I
R
N
P
A
S
L
K
I
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
40.31
40%
-25
- C5 -
-
2G1T
1
ABL1_HUMAN
B:
[12-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
513
Blastp_CBE
40.33
40%
-42
- C5 -
-
2Z60
1
ABL1_MOUSE
A:
[10-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
456
Blastp_CBE
40.28
40%
-36
- C5 -
-
4ZOG
5
ABL1_HUMAN
A:
[9-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
40.31
43%
-39
- C5 -
-
4XLI
1
ABL2_MOUSE
A:
[5-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
----
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
-
E
-
P
--
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
S
R
-
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
-
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
---
T
M
F
H
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
40.30
40%
-33
- C5 -
-
3K5V
2
ABL1_MOUSE
B:
[6-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
---
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
40.28
40%
-30
- C5 -
-
1FPU
1
ABL1_MOUSE
A:
[6-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
40.24
40%
-36
- C5 -
-
4XEY
1
ABL1_HUMAN
B:
[97-384]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
Y
G
V
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
------
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
---
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
482
Blastp_CBE
40.21
40%
-36
- C5 -
-
3UE4
1
ABL1_HUMAN
B:
[12-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
--
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
433
Blastp_CBE
40.17
40%
-38
- C5 -
-
2QOH
1
ABL1_MOUSE
A:
[10-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
523
Blastp_CBE
40.07
39%
-56
- C5 -
-
2V7A
1
ABL1_HUMAN
A:
[7-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
T
A
--
H
A
---
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
520
Blastp_CBE
40.07
40%
-35
- C5 -
-
3OY3
1
ABL1_MOUSE
B:
[10-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
40.13
40%
-31
- C5 -
-
3MS9
2
ABL1_MOUSE
B:
[6-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
---
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
40.10
39%
-39
- C5 -
-
4GU9
1
FAK1_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
--
S
-
P
--
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
--------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
40.09
41%
-52
- C5 -
-
2G2F
1
ABL1_HUMAN
B:
[12-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
-----
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
----
Y
T
A
P
A
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
526
Blastp_CBE
40.02
41%
-46
- C5 -
-
3EQR
1
ACK1_HUMAN
B:
[4-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
E
K
D
---
L
--
R
L
L
E
---
K
-----
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
-
P
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
K
P
D
V
L
S
Q
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
-
T
-
P
--
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
-
G
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
-
N
D
-
D
H
Y
--
V
M
----
R
-
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
40.07
40%
-33
- C5 -
-
2HZI
1
ABL1_HUMAN
A:
[14-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
434
Blastp_CBE
40.02
40%
-34
- C5 -
-
6HD6
1
ABL1_MOUSE
B:
[6-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
---
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
40.04
41%
-56
- C5 -
-
4ID7
1
ACK1_HUMAN
A:
[4-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
E
K
D
---
L
--
R
L
L
E
---
K
-----
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
-
P
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
K
P
-----
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
-
T
-
P
--
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
-
G
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
P
Q
-
N
D
-
D
H
Y
--
V
M
Q
-
E
H
R
-
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
40.02
39%
-35
- C5 -
-
1MQB
1
B:
[35-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
-----
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-------------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
509
Blastp_CBE
39.96
39%
-35
- C5 -
-
3QRJ
1
ABL1_HUMAN
B:
[11-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
502
Blastp_CBE
40.01
40%
-37
- C5 -
-
3DK3
1
ABL1_MOUSE
A:
[8-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
----
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
F
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
522
Blastp_CBE
39.93
39%
-61
- C5 -
-
2V7A
1
ABL1_HUMAN
B:
[8-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
T
A
--
H
A
---
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
521
Blastp_CBE
39.93
40%
-34
- C5 -
-
3OY3
1
ABL1_MOUSE
A:
[10-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
497
Blastp_CBE
39.99
38%
-37
- C5 -
-
6FNJ
1
EPHB4_HUMAN
A:
[12-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
---
V
--
S
Y
V
K
IEE
V
-----
I
G
A
G
E
F
G
E
V
C
R
G
R
L
-
K
-
A
P
-
G
K
K
E
S
C
------
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
-
T
N
S
-
M
--
P
-
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
D
-
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
------------------------
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
-
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
---
K
M
I
R
N
P
A
S
L
K
I
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
39.97
40%
-29
- C5 -
-
3KFA
1
ABL1_MOUSE
B:
[10-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
39.96
40%
-47
- C5 -
-
3BZ3
1
A:
[3-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
---
R
--
E
R
I
E
---
L
GRC--
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
------
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
432
Blastp_CBE
39.95
40%
-35
- C5 -
-
2QOH
1
ABL1_MOUSE
B:
[10-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
---
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
342
Blastp_CBE
39.93
39%
-28
- C5 -
-
5IA0
11
EPHA2_HUMAN
B:
[6-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
S
----
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
--------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
461
Blastp_CBE
39.92
40%
-42
- C5 -
-
2HZI
1
ABL1_HUMAN
B:
[14-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
----
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
39.89
39%
-36
- C5 -
-
5I9W
3
A:
[11-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
---------
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
404
Blastp_CBE
39.86
41%
-59
- C5 -
-
5TO8
1
A:
[19-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
I
-----
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
-
T
N
H
K
-
G
E
--
K
I
N
-----
V
A
V
K
T
C
K
K
D
C
T
--
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
-----
E
--
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
-
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
--
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
R
------------------------
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
-
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
DVY
Q
M
E
K
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
495
Blastp_CBE
39.80
38%
-17
- C5 -
-
6FNK
3
A:
[9-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
F
A
K
E
I
D
---
V
--
S
Y
V
K
IEE
V
-----
I
G
A
G
E
F
G
E
V
C
R
G
R
L
-
K
-
A
P
-
G
K
K
E
S
C
------
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
-
T
N
S
-
M
--
P
-
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
D
-
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
-
E
E--------------
G
-
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
-
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
---
K
M
I
R
N
P
A
S
L
K
I
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
484
Blastp_CBE
39.84
40%
-24
- C5 -
-
2G1T
1
ABL1_HUMAN
D:
[12-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
39.82
39%
-26
- C5 -
-
6FNH
12
EPHA2_HUMAN
A:
[8-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
--
S
G
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-
E
-
D
-------------
G
-
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
P-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
487
Blastp_CBE
39.80
40%
-23
- C5 -
-
2G1T
1
ABL1_HUMAN
A:
[12-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
510
Blastp_CBE
39.74
39%
-43
- C5 -
-
3QRJ
1
ABL1_HUMAN
A:
[12-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
-----
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
39.69
40%
-31
- C5 -
-
1IEP
1
ABL1_MOUSE
B:
[6-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
39.62
38%
-44
- C5 -
-
2YN8
1
B:
[12-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
E
I
D
---
V
--
S
Y
V
K
IEE
V
-----
I
G
A
G
E
F
G
E
V
C
R
G
R
L
-
K
-
A
P
-
G
K
K
E
S
C
------
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
-
T
N
S
-
M
--
P
-
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
D
-
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
---------------------------
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
-
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
---
K
M
I
R
N
P
A
S
L
K
I
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
39.64
40%
-36
- C5 -
-
3MSS
2
ABL1_MOUSE
C:
[3-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
373
Blastp_CBE
39.64
39%
-34
- C5 -
-
4D58
1
?
B:
[4-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
--
E
N
P
A
M
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
39.64
39%
-38
- C5 -
-
6Q7C
1
?
A:
[5-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
--
F
G
E
V
Y
K
G
M
L
-
K
-
T
-----
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
--------------------
G
-
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
491
Blastp_CBE
39.63
41%
-54
- C5 -
-
4EWH
1
ACK1_HUMAN
A:
[4-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
E
K
D
---
L
--
R
L
L
E
---
K
-----
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
-
P
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
K
P
D
V
L
S
Q
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
-
T
-
P
--
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
-
G
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
-
P
-
Q
N
-
D
D
H
--
V
M
Q
-
E
H
R
-
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
39.62
40%
-34
- C5 -
-
3MSS
2
ABL1_MOUSE
A:
[3-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
354
Blastp_CBE
39.59
39%
-34
- C5 -
-
3PXK
1
B:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
--
E
N
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
39.55
39%
-35
- C5 -
-
6HEV
1
A:
[6-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--------
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
-----------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
39.48
40%
-32
- C5 -
-
6BL8
1
ABL1_HUMAN
A:
[5-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
F
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
39.50
39%
-35
- C5 -
-
4K8A
1
FAK1_HUMAN
A:
[7-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
--
S
-
P
--
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
-------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
39.43
40%
-33
- C5 -
-
3UE4
1
ABL1_HUMAN
A:
[12-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
39.48
40%
-29
- C5 -
-
4ZOG
2
ABL1_HUMAN
B:
[9-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
----
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
39.47
40%
-35
- C5 -
-
3QRI
1
ABL1_HUMAN
B:
[10-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
-----
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
39.45
39%
-53
- C5 -
-
2GQG
2
ABL1_HUMAN
B:
[6-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
T
A
--
H
A
---
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
39.43
39%
-38
- C5 -
-
4KAB
1
B:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
--
S
-
P
E
-
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
39.42
39%
-23
- C5 -
-
5NKA
2
A:
[11-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
S
-
S
G
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
-----------------------
G
-
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
V--
S
I
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
39.39
39%
-29
- C5 -
-
2IJM
1
FAK1_HUMAN
A:
[6-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
--
E
N
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
39.38
38%
-38
- C5 -
-
6FNI
1
A:
[12-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
---
V
--
S
Y
V
K
IEE
V
-----
I
G
A
G
E
F
G
E
V
C
R
G
R
L
-
K
-
A
P
-
G
K
K
E
S
C
------
V
A
I
K
T
L
-----
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
-
T
N
S
-
M
--
P
-
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
D
-
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
---------------------
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
-
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
---
K
M
I
R
N
P
A
S
L
K
I
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
39.33
39%
-28
- C5 -
-
6HEY
1
A:
[6-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
S
-----
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
----------------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
335
Blastp_CBE
39.34
39%
-29
- C5 -
-
5NJZ
1
A:
[10-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
----
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
-----------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
39.28
40%
-34
- C5 -
-
6NPE
2
ABL1_HUMAN
A:
[23-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
-----
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
301
Blastp_CBE
39.33
39%
-32
- C5 -
-
6Q7D
1
?
A:
[6-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
-----
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
340
Blastp_CBE
39.32
39%
-37
- C5 -
-
5IA1
2
A:
[11-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
---------
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
-----------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
494
Blastp_CBE
39.31
38%
-14
- C5 -
-
6FNM
1
A:
[13-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
---
V
--
S
Y
V
K
IEE
V
-----
I
G
A
G
E
F
G
E
V
C
R
G
R
L
-
K
-
A
P
-
G
K
K
E
S
C
------
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
-
T
N
S
-
M
--
P
-
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
D
-
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
-
E
E--------------
G
-
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
-
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
---
K
M
I
R
N
P
A
S
L
K
I
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
39.28
39%
-22
- C5 -
-
5I9V
1
A:
[11-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
S
-
S
G
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-------------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
479
Blastp_CBE
39.27
40%
-28
- C5 -
-
2HIW
1
ABL1_HUMAN
A:
[12-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
39.23
40%
-32
- C5 -
-
3MSS
2
ABL1_MOUSE
D:
[3-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
39.23
39%
-36
- C5 -
-
4BRX
1
FAK1_CHICK
A:
[3-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGR-
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
--
E
N
P
A
M
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
39.22
39%
-37
- C5 -
-
4KAB
1
FAK1_HUMAN
A:
[6-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
--
S
-
P
--
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
--------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
39.14
39%
-30
- C5 -
-
4D4S
1
B:
[5-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
--
E
N
P
A
M
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
314
Blastp_CBE
39.14
39%
-27
- C5 -
-
6FNG
7
A:
[5-303]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--------
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-----------------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
39.12
39%
-36
- C5 -
-
4C7T
1
A:
[4-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
--
E
N
P
A
M
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
39.15
40%
-37
- C5 -
-
3DK3
1
ABL1_MOUSE
B:
[8-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
----
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
F
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
39.10
40%
-30
- C5 -
-
3CS9
1
ABL1_HUMAN
D:
[14-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
------------
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
39.10
40%
-28
- C5 -
-
1FPU
1
ABL1_MOUSE
B:
[6-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
--------
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
39.14
39%
-31
- C5 -
-
2JKQ
1
A:
[4-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
--
E
N
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
489
Blastp_CBE
39.13
41%
-32
- C5 -
-
2HZ0
1
ABL1_HUMAN
A:
[10-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
317
Blastp_CBE
39.12
39%
-2
- C5 -
-
5NKH
1
A:
[7-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
S
-
S
G
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-
E
-
D
D
P
E
A
T
--
Y
T
T
-
S
G
G
-
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
39.11
40%
-34
- C5 -
-
3MS9
2
ABL1_MOUSE
A:
[4-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
----
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
350
Blastp_CBE
39.10
39%
-28
- C5 -
-
4KAO
1
B:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
----
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
-------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
39.09
40%
-31
- C5 -
-
3MSS
2
ABL1_MOUSE
B:
[3-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
39.08
39%
-26
- C5 -
-
5NK0
1
A:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
S
-
S
G
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PV-
S
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
39.06
39%
-26
- C5 -
-
6FNH
5
C:
[6-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
---
G
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
39.05
40%
-34
- C5 -
-
3IK3
1
ABL1_MOUSE
B:
[10-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
517
Blastp_CBE
38.98
40%
-38
- C5 -
-
4TWP
1
ABL1_HUMAN
A:
[5-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
-----
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
39.01
39%
-29
- C5 -
-
6I8Z
1
A:
[6-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
--
E
N
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
38.98
39%
-35
- C5 -
-
6Q7G
1
?
A:
[7-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
-----
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
38.96
40%
-37
- C5 -
-
2HZ4
1
ABL1_HUMAN
B:
[10-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
-----
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
38.95
39%
-34
- C5 -
-
2JKO
1
A:
[5-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
--
E
N
P
A
M
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
38.93
39%
-31
- C5 -
-
3PXK
1
FAK1_HUMAN
A:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
--
E
N
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
-------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
38.86
38%
-43
- C5 -
-
2YN8
1
EPHB4_HUMAN
A:
[14-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
---
V
--
S
Y
V
K
IEE
V
-----
I
G
A
G
E
F
G
E
V
C
R
G
R
L
--------
K
E
S
C
------
V
A
I
K
T
L
K
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
-
T
N
S
-
M
--
P
-
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
-
N
D
-
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
---------------------------
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
-
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
---
K
M
I
R
N
P
A
S
L
K
I
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
38.86
40%
-31
- C5 -
-
2E2B
1
ABL1_HUMAN
A:
[6-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
----
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
-------
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
38.86
39%
-30
- C5 -
-
6Q7B
1
?
A:
[5-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
-----
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
--------------------
G
-
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
38.85
40%
-39
- C5 -
-
4YC8
3
ABL1_HUMAN
A:
[12-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
------
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
----
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
38.84
39%
-31
- C5 -
-
2JKM
1
A:
[3-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
--
E
N
P
A
M
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
300
Blastp_CBE
38.83
39%
-29
- C5 -
-
6Q7E
1
?
A:
[7-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
------
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
38.80
39%
-31
- C5 -
-
1MQB
1
EPHA2_HUMAN
A:
[38-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
----
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-----------------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
38.75
40%
-32
- C5 -
-
2HYY
1
ABL1_HUMAN
D:
[10-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
--
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
38.76
40%
-36
- C5 -
-
3KF4
1
ABL1_MOUSE
A:
[10-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
-----
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
38.73
39%
-1
- C5 -
-
5NKE
1
A:
[11-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
S
-
S
G
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-
E
-
D
D
P
E
A
T
--
Y
T
T
-
S
G
G
-
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
38.75
39%
-27
- C5 -
-
6HES
2
A:
[5-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--------
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
38.73
39%
-32
- C5 -
-
2J0M
1
?
B:
[4-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
--
E
N
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
38.72
40%
-35
- C5 -
-
4YC8
3
ABL1_HUMAN
B:
[12-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
------
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
322
Blastp_CBE
38.69
39%
-10
- C5 -
-
5NKC
2
A:
[7-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--------
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-
E
-
D
D
P
E
A
T
--
Y
-------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
38.67
40%
-33
- C5 -
-
2HYY
1
ABL1_HUMAN
B:
[10-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
-
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
38.66
40%
-35
- C5 -
-
3KF4
1
ABL1_MOUSE
B:
[10-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
---
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
490
Blastp_CBE
38.65
41%
-56
- C5 -
-
4EWH
1
ACK1_HUMAN
B:
[4-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
E
K
D
---
L
--
R
L
L
E
---
K
-----
L
G
D
G
S
F
G
V
V
R
R
G
E
W
D
A
-
P
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
K
P
D
V
L
S
Q
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
-
T
-
P
--
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
-
G
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
-
P
-
Q
N
-
D
D
H
--
V
M
Q
-
E
H
R
-
K
V
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
336
Blastp_CBE
38.64
39%
-4
- C5 -
-
5IA5
3
A:
[11-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
S
----
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-
E
-
D
D
P
E
A
T
--
Y
T
T
-
S
G
G
-
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
38.57
40%
-36
- C5 -
-
6NPV
2
ABL1_HUMAN
A:
[23-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
-----
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
343
Blastp_CBE
38.61
39%
-33
- C5 -
-
5IA0
7
EPHA2_HUMAN
A:
[10-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
-----
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
P-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
38.56
39%
-37
- C5 -
-
4I4F
2
A:
[10-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
-----
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
----------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
38.58
39%
-27
- C5 -
-
2IJM
1
B:
[6-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
--
E
N
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
38.57
39%
-33
- C5 -
-
5I9Z
2
A:
[10-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
--
G
E
V
Y
K
G
M
L
-
K
-
T
-----
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
--------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
38.56
39%
-4
- C5 -
-
5NK4
2
A:
[7-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
---------
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-
E
-
D
D
P
E
A
T
--
Y
T
T
-
S
G
G
-
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
341
Blastp_CBE
38.55
39%
-25
- C5 -
-
5IA0
7
C:
[6-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
---
G
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
--
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
38.48
39%
-19
- C5 -
-
4K9Y
1
A:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
--
S
-
P
E
N
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
-
E
--
D
-
S
T
Y
--
Y
K
A
-
S
K
G
-
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
351
Blastp_CBE
38.47
39%
-35
- C5 -
-
4KAO
1
FAK1_HUMAN
A:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
-----
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
-------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
473
Blastp_CBE
38.44
40%
-35
- C5 -
-
6NPU
2
ABL1_HUMAN
A:
[23-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
-----
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
38.39
40%
-34
- C5 -
-
6BL8
1
ABL1_HUMAN
B:
[5-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
---
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
F
T
--
A
H
---
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
38.42
39%
-34
- C5 -
-
6HEU
1
A:
[6-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
-----
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
38.39
39%
-31
- C5 -
-
2ETM
1
FAK1_HUMAN
A:
[7-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
--
E
N
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
-
E
-----------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
38.32
39%
-29
- C5 -
-
2JKK
1
?
A:
[3-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
--
E
N
P
A
M
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
38.32
39%
-26
- C5 -
-
2ETM
1
B:
[5-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
--
E
N
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
38.27
40%
-29
- C5 -
-
2HZN
1
ABL1_MOUSE
A:
[6-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
---
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
--
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
38.31
39%
-0
- C5 -
-
5NKF
1
A:
[11-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
--
S
G
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-
E
-
D
D
P
E
A
T
--
Y
T
T
-
S
G
G
-
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
38.27
43%
-26
- C5 -
-
3GVU
2
ABL2_HUMAN
A:
[29-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
-
E
-
P
--
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-----
G
D
-
T
Y
T
--------
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
-
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
---
T
M
F
H
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
500
Blastp_CBE
38.15
40%
-57
- C5 -
-
3DK6
1
ABL1_MOUSE
A:
[8-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
--
G
Q
F
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
-----
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
T
A
--
H
A
---
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
38.07
40%
-33
- C5 -
-
3PYY
1
ABL1_HUMAN
A:
[23-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
----
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
38.10
39%
-9
- C5 -
-
5NKD
2
A:
[6-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
---------
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-
E
-
D
D
P
E
A
T
--
Y
-----
G
-
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
531
Blastp_CBE
38.08
41%
-60
* C5 *
-
5ZXB
1
ACK1_HUMAN
A:
[4-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
E
K
D
---
L
--
R
L
L
E
---
K
-----
L
G
D
---
G
V
V
R
R
G
E
W
D
A
-
P
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
---------
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
-
T
-
P
--
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
-
G
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
---------------------------
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
38.07
39%
-26
- C5 -
-
5NKI
1
A:
[10-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--------
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
--------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
38.04
39%
-22
- C5 -
-
4GU6
1
B:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
--
E
N
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
425
Blastp_CBE
38.03
40%
-35
- C5 -
-
2HYY
1
ABL1_HUMAN
C:
[10-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
-
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
------
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
478
Blastp_CBE
38.02
40%
-24
- C5 -
-
2HIW
1
ABL1_HUMAN
B:
[12-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
356
Blastp_CBE
37.94
39%
-36
- C5 -
-
4Q9S
1
A:
[9-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
----
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
---------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
37.94
39%
-7
- C5 -
-
5I9Y
4
A:
[6-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
----
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-
E
-
D
D
P
E
A
T
--
Y
---------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
460
Blastp_CBE
37.89
40%
-28
- C5 -
-
3CS9
1
ABL1_HUMAN
A:
[14-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
----
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
37.86
39%
-4
- C5 -
-
5NK5
1
A:
[11-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
---
F
G
E
V
Y
K
G
M
L
-
K
-
T
S
-
S
G
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-
E
-
D
D
P
E
A
T
--
Y
T
T
--
G
G
-
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PV-
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
37.84
40%
-30
- C5 -
-
2HYY
1
ABL1_HUMAN
A:
[10-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
-
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
353
Blastp_CBE
37.82
39%
-18
- C5 -
-
4GU6
1
FAK1_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
----
N
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
-
E
--
D
-
S
T
Y
--
Y
K
A
-
S
K
G
-
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
37.79
39%
-22
- C5 -
-
5NK8
1
A:
[11-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
----
G
E
V
Y
K
G
M
L
-
K
-
T
S
-
S
G
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
--------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
339
Blastp_CBE
37.81
39%
0
- C5 -
-
5IA2
3
A:
[4-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
V
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
-----
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-
E
-
D
D
P
E
A
T
--
Y
T
T
-
S
G
G
-
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
37.79
39%
2
- C5 -
-
5NKG
1
A:
[11-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
S
-
S
G
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-
E
-
D
D
P
E
A
T
--
Y
T
T
-
S
G
G
-
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
37.66
40%
-34
- C5 -
-
2E2B
1
ABL1_HUMAN
B:
[6-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
N
Y
D
K
W
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
-----
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---------
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
372
Blastp_CBE
37.66
39%
-29
- C5 -
-
4D5H
1
FAK1_CHICK
A:
[5-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
--
E
N
P
A
M
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
-------------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
37.65
39%
-26
- C5 -
-
6HET
1
A:
[11-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
------
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
512
Blastp_CBE
37.59
40%
-31
- C5 -
-
3IK3
1
ABL1_MOUSE
A:
[10-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---------
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
37.62
39%
6
- C5 -
-
6FNH
6
EPHA2_HUMAN
B:
[8-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
S
----
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-
E
-
D
D
P
E
A
-----------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
37.59
39%
-5
- C5 -
-
5IA4
1
A:
[11-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
------
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-
E
-
D
D
P
E
A
T
--
Y
T
T
-
S
G
G
-
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
37.58
39%
-31
- C5 -
-
6FNF
1
A:
[12-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
-----
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
367
Blastp_CBE
37.49
39%
-17
- C5 -
-
4EBV
3
A:
[31-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
--
E
N
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
-----------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
305
Blastp_CBE
37.33
39%
-27
- C5 -
-
6HEX
1
A:
[11-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--------
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
37.28
39%
-21
- C5 -
-
4EBW
1
A:
[31-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
----
N
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
-----------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
37.27
39%
-23
- C5 -
-
6HEW
1
A:
[11-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--------
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
--------------------
G
-
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
530
Blastp_CBE
37.20
41%
-51
- C5 -
-
5ZXB
1
ACK1_HUMAN
B:
[4-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
E
K
D
---
L
--
R
L
L
E
---
K
-----
L
G
D
----
V
V
R
R
G
E
W
D
A
-
P
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
------
Q
P
E
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
-
T
-
P
--
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
-
G
H
F
-
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
---------------------------
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
299
Blastp_CBE
37.25
39%
-26
- C5 -
-
6Q7F
1
?
A:
[11-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
------
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
--------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
37.24
39%
-4
- C5 -
-
5I9X
5
A:
[10-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
------
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-
E
-
D
D
P
E
A
T
--
Y
-----
G
-
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
332
Blastp_CBE
37.20
39%
-2
- C5 -
-
5NK2
2
A:
[4-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
V
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--------
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-
E
-
D
D
P
E
A
T
--
Y
-----
G
-
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
37.11
40%
-36
- C5 -
-
6NPE
3
ABL1_HUMAN
B:
[23-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
-------------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
37.16
39%
-29
- C5 -
-
2J0L
1
A:
[3-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
--
E
N
P
A
M
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
-
E
-
D
S
-
T
K
Y
----
A
-
S
K
G
-
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
37.15
40%
-52
- C5 -
-
1U54
1
ACK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
L
T
C
L
I
G
E
K
D
---
L
--
R
L
L
E
---
K
-----
L
G
D
---
G
V
V
R
R
G
E
W
D
A
-
P
S
-
G
K
T
V
S
V
A
-----
V
K
C
L
---------
A
M
D
D
F
I
R
E
V
N
A
M
H
S
L
D
H
R
N
L
I
R
L
Y
G
V
V
-
L
-
T
-
P
--
P
-
M
K
M
V
T
E
L
A
P
L
G
S
L
L
D
R
L
R
K
-
H
Q
-
G
H
F
L
L
G
T
L
S
R
Y
A
V
Q
V
A
E
G
M
G
Y
L
E
S
K
R
F
I
H
R
D
L
A
A
R
N
L
L
L
A
T
R
D
L
V
K
I
G
D
F
G
L
M
R
A
L
-
P
-
Q
N
-
D
D
H
--
V
M
Q
-
E
H
R
-
K
-
P
F
A
W
C
A
P
E
S
L
K
T
R
T
F
S
H
A
S
D
T
W
M
F
G
V
T
L
W
E
M
F
T
Y
G
Q
E
P
W
I
G
L
N
G
S
Q
I
L
H
K
I
D
K
E
G
E
R
L
P
R
P
E
D
C
P
Q
D
I
Y
N
V
M
V
Q
C
W
A
H
K
P
E
D
R
P
T
F
V
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
37.08
39%
-22
- C5 -
-
4D4V
2
B:
[5-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
--
E
N
P
A
M
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
-------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
37.11
39%
-20
- C5 -
-
6GCX
1
FAK1_CHICK
A:
[3-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
--
E
N
P
A
M
A
-----
V
A
I
K
T
C
K
N
--
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
541
Fugue
37.09
38%
-44
- C5 -
-
1BYG
1
CSK_HUMAN
A:
[15-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
---
L
--
K
L
L
Q
---
T
-----
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
-
R
G--------
N
K
-----
V
A
V
K
C
I
K
-----
N
D
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
-
V
----EE
G
-
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
-
R
G
R
S
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
------------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L
K
D
V
V
P
R
V
E
K
-
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
---
H
I
K
T
H
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
359
Blastp_CBE
37.08
39%
-32
- C5 -
-
1MP8
1
A:
[9-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
---
I
--
Q
R
E
R
---
I
ELGRC
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
-
M
-
S
P
----
P
A
L
A
-----
V
A
I
K
T
C
K
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
-
E
-
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
-
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
---------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
---
T
I
L
E
E
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
36.96
39%
-2
- C5 -
-
5NK3
2
A:
[7-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
-
T
-----
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-
E
-
D
D
P
E
A
T
--
Y
T
----
G
-
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
36.95
40%
-33
- C5 -
-
3OXZ
1
ABL1_MOUSE
A:
[10-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---------------
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
499
Blastp_CBE
36.69
40%
-54
- C5 -
-
3DK6
1
ABL1_MOUSE
B:
[8-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
------------
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
-----
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
T
A
--
H
A
---
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
36.59
40%
-36
- C5 -
-
3CS9
1
ABL1_HUMAN
C:
[14-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
-----
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
--------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
36.51
40%
-34
- C5 -
-
6NPU
5
ABL1_HUMAN
B:
[23-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
----------------------
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
36.54
39%
-4
- C5 -
-
5NK6
1
A:
[11-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--------
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-
E
-
D
D
P
E
A
T
--
Y
----
G
G
-
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
36.51
39%
-2
- C5 -
-
5NK1
1
A:
[10-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--------
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-
E
-
D
D
P
E
A
T
--
Y
-----
G
-
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
36.45
39%
-0
- C5 -
-
5NK9
1
A:
[11-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--------
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-
E
-
D
D
P
E
A
T
--
Y
T
T
---
G
-
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
36.40
39%
-2
- C5 -
-
5NK7
1
A:
[10-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--------
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-
E
-
D
D
P
E
A
T
--
Y
-----
G
-
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
470
Blastp_CBE
36.24
40%
-29
- C5 -
-
6NPV
5
ABL1_HUMAN
B:
[23-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
----------------------
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
35.87
40%
-27
- C5 -
-
3CS9
1
ABL1_HUMAN
B:
[14-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
---
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
--------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
323
Blastp_CBE
35.84
39%
-1
- C5 -
-
5NKB
3
A:
[11-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
PSC
V
--
T
R
Q
K
---
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--------
K
K
E
V
P
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
-
K
Y
K
--
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
-
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-
E
-
D
D
P
E
A
T
--
Y
T
T
---
G
-
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
---
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
D
PRV
S
I
R
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
35.77
44%
-54
- C5 -
-
4UEU
1
?
A:
[11-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
---
I
--
T
L
E
R
---
K
-----
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
-------
R
N
Y
N
I
E
-----
V
A
V
K
T
L
K
E
--
G
T
M
S
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
-
T
-
K
E
P
--
P
-
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
E
G
-
H
T
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
------------------A
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
-
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
488
Blastp_CBE
35.68
41%
-38
- C5 -
-
2HZ0
1
ABL1_HUMAN
B:
[10-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
------
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
----
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
-------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
35.35
40%
-26
- C5 -
-
3PYY
3
ABL1_HUMAN
B:
[23-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
K
T
L
------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
--
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
----------------------
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
408
Blastp_CBE
35.20
40%
-26
- C5 -
-
4WA9
1
ABL1_HUMAN
A:
[10-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
M
E
R
T
D
---
I
--
T
M
K
H
---
K
-----
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-------
K
K
Y
S
L
T
-----
V
A
V
----------------------
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
-
P
------
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
-
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
-
G
D
-
T
Y
T
--
A
H
A
--
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
---
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
285
Blastp_CBE
33.83
44%
-35
- C5 -
-
4CSV
1
?
A:
[11-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
---
I
--
T
L
E
R
---
K
-----
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
-------
R
N
Y
N
I
E
-----
V
A
V
K
T
L
K
E
--
G
T
M
S
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
-
T
-
K
E
P
--
P
-
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C-----
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
-------------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
-
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
30.67
39%
-9
- C5 -
-
5MJA
1
EPHB1_HUMAN
A:
[18-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
A
K
E
I
D
---
V
--
S
F
V
K
IEE
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
----------
R
L
K
L
P
GKREI
V
A
I
K
T
L
K
A
G
Y
S
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
R
N
I
I
R
L
E
G
V
V
-
T
K
S
-
R
--
P
-
V
M
I
I
T
E
F
M
E
N
G
A
L
D
S
F
L
R
Q
-
N
D
-
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
S
E
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
Y
L
-
Q
-
D
D
-
T
S
D
P------------
V
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
-
D
Y
R
L
P
P
P
M
D
C
P
A
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
S
R
P
R
F
A
E
I
V
N
T
L
D
---
K
M
I
R
N
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
525
Blastp_CBE
29.96
39%
-19
- C5 -
-
5MJB
1
EPHB1_HUMAN
A:
[17-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
F
A
K
E
I
D
---
V
--
S
F
V
K
IEE
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
----------
R
L
K
L
P
GKREI
V
A
I
K
T
L
K
A
G
Y
S
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
R
N
I
I
R
L
E
G
V
V
-
T
K
S
-
R
--
P
-
V
M
I
I
T
E
F
M
E
N
C
A
L
D
S
F
L
R
Q
-
N
D
-
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
S
E
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
Y
L
-
Q
-------T-
T
S
S
-
L
G
G
-
K
I
P
V
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
-
D
Y
R
L
P
P
P
M
D
C
P
A
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
S
R
P
R
F
A
E
I
V
N
T
L
D
---
K
M
I
R
N
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
29.80
39%
-18
- C5 -
-
5MJA
1
B:
[18-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
A
K
E
I
D
---
V
--
S
F
V
K
IEE
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
----------
R
L
K
L
P
GKREI
V
A
I
K
T
L
K
A
G
Y
S
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
R
N
I
I
R
L
E
G
V
V
-
T
K
S
-
R
--
P
-
V
M
I
I
T
E
F
M
E
N
G
A
L
D
S
F
L
R
Q
-
N
D
-
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
S
E
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
Y
L
-
Q
-------T-
T
S
S
-
L
G
G
-
K
I
P
V
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
-
D
Y
R
L
P
P
P
M
D
C
P
A
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
S
R
P
R
F
A
E
I
V
N
T
L
D
---
K
M
I
R
N
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
524
Blastp_CBE
29.73
39%
-13
- C5 -
-
5MJB
1
B:
[17-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
F
A
K
E
I
D
---
V
--
S
F
V
K
IEE
V
-----
I
G
A
G
E
F
G
E
V
Y
K
G
----------
R
L
K
L
P
GKREI
V
A
I
K
T
L
K
A
G
Y
S
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
R
N
I
I
R
L
E
G
V
V
-
T
K
S
-
R
--
P
-
V
M
I
I
T
E
F
M
E
N
C
A
L
D
S
F
L
R
Q
-
N
D
-
G
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
S
E
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
Y
L
-
Q
-----
S
D
PT
T
S
S
-
L
G
G
-
K
I
P
V
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
-
D
Y
R
L
P
P
P
M
D
C
P
A
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
S
R
P
R
F
A
E
I
V
N
T
L
D
---
K
M
I
R
N
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------