@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ERN2_HUMAN: (2020-09-09 )
MASAVRGSRPWPRLGLQLQFAALLLGTLSPQVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTEGPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGPRDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTLQVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPPENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFVMRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPPDSEARRPCPGATGR
Atome Classification :
(61 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530........540.--........550.-----------..-----....560.......-------570..--...--..580--...------..----..590..-.-....600.........610----..--..--.----...620.---......630.......640..-.....----650------....--------.....660.-....--..670..-.....680.......690.----..---.----...700--.-.......710....--...720..---------.....730-........740-....--.--...750.---......760.......770.......780.----......790.......800...--.--...810...-....-820........830.......840.......850.......860.......870.......880.......890.......-900.......910.......920....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MASAVRGSRPWPRLG
L
Q
L
Q
F
A
A
L
L
L
G
TLSP
Q
V
H
TLRPE
N
L
L
L
V
S
TLDG
S
L
H
A
L
SKQTG
D
L
K
W
T
LRDDPVIEG
P
M
Y
V
T
E
M
A
FLSDPADG
S
L
Y
I
L
GTQKQQG
L
M
KLPFT
I
P
E
L
VHASPCRSSD
G
V
F
Y
TGRK
Q
D
A
W
F
V
VDPESG
E
T
Q
M
T
L
TTEGPST
P
R
L
Y
I
G
R
T
Q
Y
T
V
T
MHDPRA
P
A
L
RWNT
T
Y
R
RYSAPPMDGS
P
G
K
Y
M
S
H
L
A
SCG
M
G
L
L
L
T
VDPGS
G
T
V
L
W
TQDLGV
P
V
M
G
V
Y
TW
H
Q
D
G
L
R
QLP
H
L
T
L
A
R
D
T
L
H
F
L
A
L
RWG
H
I
RLPASGPR
D
T
A
T
L
F
S
T
L
D
T
Q
L
L
M
T
L
Y
VGKDET
G
F
Y
V
S
K
A
L
V
HT
G
V
A
LVPRG
L
T
LAPADGPTT
D
E
V
T
L
Q
V
SGEREGSPS
T
A
V
RYPSGSVALPS
Q
W
L
L
I
GHHEL
P
P
V
L
H
T
T
M
L
R
V
HPTLGSGTAETRPPENTQ
A
P
A
F
F
L
E
L
L
S
L
S
R
E
KLWDSELHPEEKTPDSYLGL
G
P
Q
D
L
L
A
A
S
L
T
A
V
L
L
G
G
W
I
L
F
V
MRQQQ
P
Q
V
V
E
K
QQETPLAP
A
D
F
A
H
I
S
Q
D
A
Q
S
L
H
S
G
A
S
R
R
S
Q
K
R
LQSPSKQAQPLDDPEAE
Q
L
T
V
V
G
K
I
SF
N
P
K
D
V
LGRGA-G
G
T
F
V
F
R
GQF--E--
G
R
A
V
A
V
K
R
L
L
R
E
-----------
C
F
-----
G
L
V
R
R
E
V
Q
L
L
Q
ESD-------RH
P
N
V
--
L
R
Y
--
F
C
TER--GP
Q
------
F
H
----
Y
I
A
L
E
L
C
-
R
-
A
S
L
Q
E
--
Y
V
ENPDLDRGG-----L
E
--
P
E
--
V
----
V
L
Q
Q
L
M
S
---
G
L
A
H
L
H
S
L
H
I
VHRDLKPG
N
I
L
-
I
TGPD----S--------QG
L
G
--------
R
V
V
L
S
D
F
G
L
-
C
K
KL--PAGR
C
S
F
-
S
LHSGIPGTEGWM
A
P
E
L
L
Q
----LL---P----PDSPT---
S
-
A
V
D
I
FSAG
C
V
F
Y
Y
V
--LSGGSHPF---------
G
D
S
L
Y
R
Q--ANILTG
A
P
C
L
--
A
H
L
E
--
E
--
E
V
H
D
K
V
V
---
A
R
D
L
V
G
A
M
LSPLPQPRPSAP
Q
V
L
AH
P
F
F
W
S
----
R
A
K
Q
L
Q
F
F
Q
D
V
S
D
W
L
E
KESEQ
E
--
P
--
L
V
R
A
L
EAG
G
-
C
A
V
V-RD-N
W
H
E
HISM
P
L
Q
T
D
L
R
K
F
R
SYKG
T
S
V
R
D
L
L
R
A
V
R
NKK
H
H
Y
R
EL
P
V
E
V
R
Q
A
LGQV
P
D
G
F
V
Q
Y
F
T
N
R
F
P
R
L
L
L
H
T
H
R
A
M
R
S
-CASE
S
L
F
L
PYYPPDSEARRPCPGATGR
21
Blastp_CBE
96.55
66%
-120
- C3 -
-
6URC
2
?
B:
[14-415]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
V
V
I
V
G
K
I
S
F
C
P
K
D
V
L
G
H
G
A
-
E
G
T
I
V
Y
R
G
M
F
--
D
--
N
R
D
V
A
V
K
R
I
L
P
E
-----------
C
F
-----
S
F
A
D
R
E
V
Q
L
L
R
E
S
D
-------
E
H
P
N
V
--
I
R
Y
--
F
C
T
E
K
--
D
R
Q
------
F
Q
----
Y
I
A
I
E
L
C
-
A
-
A
T
L
Q
E
--
Y
V
E
Q
K
D
F
A
H
L
G
-----
L
E
--
P
I
--
T
----
L
L
Q
Q
T
T
S
---
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
-
I
S
M
P
N
----
A
--------
H
G
K
I
--------
K
A
M
I
S
D
F
G
L
-
C
K
K
L
--
A
V
G
R
H
S
F
-
S
R
R
S
G
V
P
G
T
E
G
W
I
A
P
E
M
L
S
----
E
D
---
C
----
K
E
N
P
T
---
Y
-
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
--
I
S
E
G
S
H
P
F
---------
G
K
S
L
Q
R
Q
--
A
N
I
L
L
G
A
C
S
L
--
D
C
L
H
--
P
--
E
K
H
E
D
V
I
---
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
K
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
----
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
S
L
D
G
--
P
--
I
V
K
Q
L
E
R
G
G
-
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
------
Y
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
A
E
V
R
E
T
L
G
S
L
P
D
D
F
V
C
Y
F
T
S
R
F
P
H
L
L
A
H
T
Y
R
A
M
E
L
-
C
S
H
E
R
L
F
Q
P
Y
Y
----------------
197
HHSearch
96.44
66%
-123
- C3 -
-
4Z7H
1
B:
[5-401]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
K
I
S
F
C
P
K
D
V
L
G
H
G
A
-
E
G
T
I
V
Y
R
G
M
F
--
D
--
N
R
D
V
A
V
K
R
I
L
P
E
-----------
C
F
-----
S
F
A
D
R
E
V
Q
L
L
R
E
S
D
-------
E
H
P
N
V
--
I
R
Y
--
F
C
T
E
K
--
D
R
Q
------
F
Q
----
Y
I
A
I
E
L
C
-
A
-
A
T
L
Q
E
--
Y
V
E
Q
K
D
F
A
H
L
G
-----
L
E
--
P
I
--
T
----
L
L
Q
Q
T
T
S
---
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
-
I
S
M
P
N
----
A
--------
H
G
K
I
--------
K
A
M
I
S
D
F
G
L
-
C
K
K
L
--
A
V
G
R
H
--------
V
P
G
T
E
G
W
I
A
P
E
M
L
S
-----------------
P
T
---
Y
-
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
--
I
S
E
G
S
H
P
F
---------
G
K
S
L
Q
R
Q
--
A
N
I
L
L
G
A
C
S
L
--
D
C
L
H
--
P
--
E
K
H
E
D
V
I
---
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
K
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
----
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
S
L
D
G
--
P
--
I
V
K
Q
L
E
R
G
G
-
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
L
R
K
F
R
T
Y
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
A
E
V
R
E
T
L
G
S
L
P
D
D
F
V
C
Y
F
T
S
R
F
P
H
L
L
A
H
T
Y
R
A
M
E
L
-
C
S
H
E
R
L
F
Q
P
Y
Y
F
---------------
198
HHSearch
96.32
66%
-118
- C3 -
-
6URC
2
?
A:
[20-417]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
K
I
S
F
C
P
K
D
V
L
G
H
G
A
-
E
G
T
I
V
Y
R
G
M
F
--
D
--
N
R
D
V
A
V
K
R
I
L
P
E
-----------
C
F
-----
S
F
A
D
R
E
V
Q
L
L
R
E
S
D
-------
E
H
P
N
V
--
I
R
Y
--
F
C
T
E
K
--
D
R
Q
------
F
Q
----
Y
I
A
I
E
L
C
-
A
-
A
T
L
Q
E
--
Y
V
E
Q
K
D
F
A
H
L
G
-----
L
E
--
P
I
--
T
----
L
L
Q
Q
T
T
S
---
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
-
I
S
M
P
N
----
A
--------
H
G
K
I
--------
K
A
M
I
S
D
F
G
L
-
C
K
K
L
--
A
V
G
R
H
S
F
-
S
R
R
S
G
V
P
G
T
E
G
W
I
A
P
E
M
L
S
----
E
D
---
C
----
K
E
N
P
T
---
Y
-
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
--
I
S
E
G
S
H
P
F
---------
G
K
S
L
Q
R
Q
--
A
N
I
L
L
G
A
C
S
L
--
D
C
L
H
--
P
--
E
K
H
E
D
V
I
---
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
K
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
----
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
S
L
D
G
--
P
--
I
V
K
Q
L
E
R
G
G
-
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
L
----
T
Y
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
A
E
V
R
E
T
L
G
S
L
P
D
D
F
V
C
Y
F
T
S
R
F
P
H
L
L
A
H
T
Y
R
A
M
E
L
-
C
S
H
E
R
L
F
Q
P
Y
Y
F
H
--------------
25
Blastp_CBE
96.08
66%
-124
- C3 -
-
4Z7H
1
B:
[2-400]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
V
G
K
I
S
F
C
P
K
D
V
L
G
H
G
A
-
E
G
T
I
V
Y
R
G
M
F
--
D
--
N
R
D
V
A
V
K
R
I
L
P
E
-----------
C
F
-----
S
F
A
D
R
E
V
Q
L
L
R
E
S
D
-------
E
H
P
N
V
--
I
R
Y
--
F
C
T
E
K
--
D
R
Q
------
F
Q
----
Y
I
A
I
E
L
C
-
A
-
A
T
L
Q
E
--
Y
V
E
Q
K
D
F
A
H
L
G
-----
L
E
--
P
I
--
T
----
L
L
Q
Q
T
T
S
---
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
-
I
S
M
P
N
----
A
--------
H
G
K
I
--------
K
A
M
I
S
D
F
G
L
-
C
K
K
L
--
A
V
G
R
H
--------
V
P
G
T
E
G
W
I
A
P
E
M
L
S
-----------------
P
T
---
Y
-
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
--
I
S
E
G
S
H
P
F
---------
G
K
S
L
Q
R
Q
--
A
N
I
L
L
G
A
C
S
L
--
D
C
L
H
--
P
--
E
K
H
E
D
V
I
---
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
K
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
----
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
S
L
D
G
--
P
--
I
V
K
Q
L
E
R
G
G
-
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
L
R
K
F
R
T
Y
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
A
E
V
R
E
T
L
G
S
L
P
D
D
F
V
C
Y
F
T
S
R
F
P
H
L
L
A
H
T
Y
R
A
M
E
L
-
C
S
H
E
R
L
F
Q
P
Y
Y
----------------
1
PsiBlast_PDB
95.85
65%
-118
- C3 -
-
6URC
2
?
A:
[14-415]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
S
V
V
I
V
G
K
I
S
F
C
P
K
D
V
L
G
H
G
A
-
E
G
T
I
V
Y
R
G
M
F
--
D
--
N
R
D
V
A
V
K
R
I
L
P
E
-----------
C
F
-----
S
F
A
D
R
E
V
Q
L
L
R
E
S
D
-------
E
H
P
N
V
--
I
R
Y
--
F
C
T
E
K
--
D
R
Q
------
F
Q
----
Y
I
A
I
E
L
C
-
A
-
A
T
L
Q
E
--
Y
V
E
Q
K
D
F
A
H
L
G
-----
L
E
--
P
I
--
T
----
L
L
Q
Q
T
T
S
---
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
-
I
S
M
P
N
----
A
--------
H
G
K
I
--------
K
A
M
I
S
D
F
G
L
-
C
K
K
L
--
A
V
G
R
H
S
F
-
S
R
R
S
G
V
P
G
T
E
G
W
I
A
P
E
M
L
S
----
E
D
---
C
----
K
E
N
P
T
---
Y
-
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
--
I
S
E
G
S
H
P
F
---------
G
K
S
L
Q
R
Q
--
A
N
I
L
L
G
A
C
S
L
--
D
C
L
H
--
P
--
E
K
H
E
D
V
I
---
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
K
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
----
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
S
L
D
G
--
P
--
I
V
K
Q
L
E
R
G
G
-
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
L
----
T
Y
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
A
E
V
R
E
T
L
G
S
L
P
D
D
F
V
C
Y
F
T
S
R
F
P
H
L
L
A
H
T
Y
R
A
M
E
L
-
C
S
H
E
R
L
F
Q
P
Y
Y
----------------
4
PsiBlast_PDB
95.65
65%
-113
- C3 -
-
4U6R
3
A:
[39-439]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
V
V
I
V
G
K
I
S
F
C
P
K
D
V
L
G
H
G
A
-
E
G
T
I
V
Y
R
G
M
F
--
D
--
N
R
D
V
A
V
K
R
I
L
P
E
-----------
C
F
-----
S
F
A
D
R
E
V
Q
L
L
R
E
S
D
-------
E
H
P
N
V
--
I
R
Y
--
F
C
T
E
K
--
D
R
Q
------
F
Q
----
Y
I
A
I
E
L
C
-
A
-
A
T
L
Q
E
--
Y
V
E
Q
K
D
F
A
H
L
G
-----
L
E
--
P
I
--
T
----
L
L
Q
Q
T
T
S
---
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
-
I
S
M
P
N
----
A
--------
H
G
K
I
--------
K
A
M
I
S
D
F
G
L
-
C
K
K
L
--
A
V
G
R
H
S
F
-
S
R
R
S
G
V
P
G
T
E
G
W
I
A
P
E
M
L
S
----
E
D
---
C
----
K
E
N
P
T
---
Y
-
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
--
I
S
E
G
S
H
P
F
---------
G
K
S
L
Q
R
Q
--
A
N
I
L
L
G
A
C
S
L
--
D
C
L
H
--
P
--
E
K
H
E
D
V
I
---
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
K
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
----
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
S
L
D
G
--
P
--
I
V
K
Q
L
E
R
G
G
-
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
L
R
K
F
R
T
Y
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
A
E
V
R
E
T
L
G
T
L
P
D
D
F
V
C
Y
F
T
S
R
F
P
H
L
L
A
H
T
Y
R
A
M
E
L
-
C
S
H
E
R
L
F
Q
P
Y
Y
----------------
3
PsiBlast_PDB
94.42
65%
-118
- C3 -
-
5HGI
6
A:
[16-415]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
V
I
V
G
K
I
S
F
C
P
K
D
V
L
G
H
----
G
T
I
V
Y
R
G
M
F
--
D
--
N
R
D
V
A
V
K
R
I
L
P
E
-----------
C
F
-----
S
F
A
D
R
E
V
Q
L
L
R
E
S
D
-------
E
H
P
N
V
--
I
R
Y
--
F
C
T
E
----
R
Q
------
F
Q
----
Y
I
A
I
E
L
C
-
A
-
A
T
L
Q
E
--
Y
V
E
Q
K
D
F
A
H
L
G
-----
L
E
--
P
I
--
T
----
L
L
Q
Q
T
T
S
---
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
-
I
S
M
P
N
----
A
--------
H
G
K
I
--------
K
A
M
I
S
D
F
G
L
-
C
K
K
L
--
A
V
G
R
H
S
F
-
S
R
R
S
G
V
P
G
T
E
G
W
I
A
P
E
M
L
S
----
E
D
---
C
----
K
E
N
P
T
---
Y
-
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
--
I
S
E
G
S
H
P
F
---------
G
K
S
L
Q
R
Q
--
A
N
I
L
L
G
A
C
S
L
--
D
C
L
H
--
P
--
E
K
H
E
D
V
I
---
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
K
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
----
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
S
L
D
G
--
P
--
I
V
K
Q
L
E
R
G
G
-
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
L
---
R
T
Y
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
A
E
V
R
E
T
L
G
S
L
P
D
D
F
V
C
Y
F
T
S
R
F
P
H
L
L
A
H
T
Y
R
A
M
E
L
-
C
S
H
E
R
L
F
Q
P
Y
Y
----------------
196
HHSearch
94.34
66%
-115
- C3 -
-
6HX1
1
A:
[5-402]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
K
I
S
F
C
P
K
D
V
L
G
H
G
A
-
E
G
T
I
V
Y
R
G
M
F
--
D
--
N
R
D
V
A
V
K
R
I
L
P
E
-----------
C
F
---------------
R
E
S
D
-------
E
H
P
N
V
--
I
R
Y
--
F
C
T
E
K
--
D
R
Q
------
F
Q
----
Y
I
A
I
E
L
C
-
A
-
A
T
L
Q
E
--
Y
V
E
Q
K
D
F
A
H
L
G
-----
L
E
--
P
I
--
T
----
L
L
Q
Q
T
T
S
---
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
-
I
S
M
P
N
----
A
--------
H
G
K
I
--------
K
A
M
I
S
D
F
G
L
-
C
K
K
----
V
G
R
H
S
F
-
S
R
R
S
G
V
P
G
T
E
G
W
I
A
P
E
M
L
S
---------------
E
N
P
T
---
Y
-
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
--
I
S
E
G
S
H
P
F
---------
G
K
S
L
Q
R
Q
--
A
N
I
L
L
G
A
C
S
L
--
D
C
L
H
--
P
--
E
K
H
E
D
V
I
---
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
K
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
----
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
S
L
D
G
--
P
--
I
V
K
Q
L
E
R
G
G
-
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
L
R
K
F
R
T
Y
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
A
E
V
R
E
T
L
G
S
L
P
D
D
F
V
C
Y
F
T
S
R
F
P
H
L
L
A
H
T
Y
R
A
M
E
L
-
C
S
H
E
R
L
F
Q
P
Y
Y
F
H
--------------
8
PsiBlast_PDB
94.01
66%
-116
- C3 -
-
6HX1
1
A:
[2-400]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
V
G
K
I
S
F
C
P
K
D
V
L
G
H
G
A
-
E
G
T
I
V
Y
R
G
M
F
--
D
--
N
R
D
V
A
V
K
R
I
L
P
E
-----------
C
F
---------------
R
E
S
D
-------
E
H
P
N
V
--
I
R
Y
--
F
C
T
E
K
--
D
R
Q
------
F
Q
----
Y
I
A
I
E
L
C
-
A
-
A
T
L
Q
E
--
Y
V
E
Q
K
D
F
A
H
L
G
-----
L
E
--
P
I
--
T
----
L
L
Q
Q
T
T
S
---
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
-
I
S
M
P
N
----
A
--------
H
G
K
I
--------
K
A
M
I
S
D
F
G
L
-
C
K
K
----
V
G
R
H
S
F
-
S
R
R
S
G
V
P
G
T
E
G
W
I
A
P
E
M
L
S
---------------
E
N
P
T
---
Y
-
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
--
I
S
E
G
S
H
P
F
---------
G
K
S
L
Q
R
Q
--
A
N
I
L
L
G
A
C
S
L
--
D
C
L
H
--
P
--
E
K
H
E
D
V
I
---
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
K
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
----
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
S
L
D
G
--
P
--
I
V
K
Q
L
E
R
G
G
-
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
L
R
K
F
R
T
Y
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
A
E
V
R
E
T
L
G
S
L
P
D
D
F
V
C
Y
F
T
S
R
F
P
H
L
L
A
H
T
Y
R
A
M
E
L
-
C
S
H
E
R
L
F
Q
P
Y
Y
----------------
6
PsiBlast_PDB
93.98
66%
-117
- C3 -
-
4Z7H
1
ERN1_HUMAN
A:
[2-400]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
V
G
K
I
S
F
C
P
K
D
V
L
G
H
G
A
-
E
G
T
I
V
Y
R
G
M
F
--
D
--
N
R
D
V
A
V
K
R
I
L
P
E
-----------
C
F
-----
S
F
A
D
R
E
V
Q
L
L
R
E
S
D
-------
E
H
P
N
V
--
I
R
Y
--
F
C
T
E
K
--
D
R
Q
------
F
Q
----
Y
I
A
I
E
L
C
-
A
-
A
T
L
Q
E
--
Y
V
E
Q
K
D
F
A
H
L
G
-----
L
E
--
P
I
--
T
----
L
L
Q
Q
T
T
S
---
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
-
I
S
M
P
N
----
A
--------
H
G
K
I
--------
K
A
M
I
S
D
F
G
L
-
C
K
K
L
--
A
V
G
R
H
S
F
-
S
-----
P
G
T
E
G
W
I
A
P
E
M
L
S
----------------
N
P
T
---
Y
-
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
--
I
S
E
G
S
H
P
F
---------
G
K
S
L
Q
R
Q
--
A
N
I
L
L
G
A
C
S
L
--
D
C
L
H
--
P
--
E
K
H
E
D
V
I
---
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
K
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
----
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
S
L
D
G
--
P
--
I
V
K
Q
L
E
R
G
G
-
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
-------
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
A
E
V
R
E
T
L
G
S
L
P
D
D
F
V
C
Y
F
T
S
R
F
P
H
L
L
A
H
T
Y
R
A
M
E
L
-
C
S
H
E
R
L
F
Q
P
Y
Y
----------------
29
Blastp_CBE
93.94
66%
-130
- C3 -
-
4YZ9
1
C:
[2-400]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
V
G
K
I
S
F
C
P
K
D
V
L
G
H
G
A
-
E
G
T
I
V
Y
R
G
M
F
--
D
--
N
R
D
V
A
V
K
R
I
L
P
E
-----------
C
F
-----
S
F
A
D
R
E
V
Q
L
L
R
E
S
D
-------
E
H
P
N
V
--
I
R
Y
--
F
C
T
E
K
--
D
R
Q
------
F
Q
----
Y
I
A
I
E
L
C
-
A
-
A
T
L
Q
E
--
Y
V
E
Q
--
F
A
H
L
G
-----
L
E
--
P
I
--
T
----
L
L
Q
Q
T
T
S
---
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
-
I
S
M
P
N
----
A
--------
H
G
K
I
--------
K
A
M
I
S
D
F
G
L
-
C
---------------------
T
E
G
W
I
A
P
E
M
L
S
----------------
N
P
T
---
Y
-
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
--
I
S
E
G
S
H
P
F
---------
G
K
S
L
Q
R
Q
--
A
N
I
L
L
G
A
C
S
L
--
D
C
L
H
--
P
--
E
K
H
E
D
V
I
---
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
K
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
----
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
S
L
D
G
--
P
--
I
V
K
Q
L
E
R
G
G
-
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
L
R
K
F
R
T
Y
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
A
E
V
R
E
T
L
G
S
L
P
D
D
F
V
C
Y
F
T
S
R
F
P
H
L
L
A
H
T
Y
R
A
M
E
L
-
C
S
H
E
R
L
F
Q
P
Y
Y
----------------
9
PsiBlast_PDB
93.90
66%
-125
- C3 -
-
4YZ9
1
ERN1_HUMAN
A:
[2-400]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
V
G
K
I
S
F
C
P
K
D
V
L
G
H
G
A
-
E
G
T
I
V
Y
R
G
M
F
--
D
--
N
R
D
V
A
V
K
R
I
L
P
E
-----------
C
F
-----
S
F
A
D
R
E
V
Q
L
L
R
E
S
D
-------
E
H
P
N
V
--
I
R
Y
--
F
C
T
E
K
--
D
R
Q
------
F
Q
----
Y
I
A
I
E
L
C
-
A
-
A
T
L
Q
E
--
Y
V
E
Q
K
D
F
A
H
L
G
-----
L
E
--
P
I
--
T
----
L
L
Q
Q
T
T
S
---
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
-
I
S
M
P
N
----
A
--------
H
G
K
I
--------
K
A
M
I
S
D
F
G
L
-
C
--------------------
G
T
E
G
W
I
A
P
E
M
L
----------------
E
N
P
T
---
Y
-
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
--
I
S
E
G
S
H
P
F
---------
G
K
S
L
Q
R
Q
--
A
N
I
L
L
G
A
C
S
L
--
D
C
L
H
--
P
--
E
K
H
E
D
V
I
---
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
K
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
----
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
S
L
D
G
--
P
--
I
V
K
Q
L
E
R
G
G
-
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
L
R
K
F
R
T
Y
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
A
E
V
R
E
T
L
G
S
L
P
D
D
F
V
C
Y
F
T
S
R
F
P
H
L
L
A
H
T
Y
R
A
M
E
L
-
C
S
H
E
R
L
F
Q
P
Y
Y
----------------
32
Blastp_CBE
93.70
64%
-126
- C3 -
-
4PL5
1
ERN1_MOUSE
C:
[20-419]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
V
I
V
G
K
I
S
F
C
P
K
D
V
L
G
H
G
A
-
E
G
T
I
V
Y
K
G
M
F
--
D
--
N
R
D
V
A
V
K
R
I
L
P
E
-----------
C
F
-----
S
F
A
D
R
E
V
Q
L
L
R
E
S
D
-------
E
H
P
N
V
--
I
R
Y
--
F
C
T
E
K
--
D
R
Q
------
F
Q
----
Y
I
A
I
E
L
C
-
A
-
A
T
L
Q
E
--
Y
V
E
Q
K
D
F
A
H
L
G
-----
L
E
--
P
I
--
T
----
L
L
H
Q
T
T
S
---
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
-
L
S
M
P
N
----
A
--------
H
G
R
I
--------
K
A
M
I
S
D
F
G
L
-
C
K
K
L
--
A
------------
V
P
G
T
E
G
W
I
A
P
E
M
L
S
----------------
N
P
T
---
Y
-
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
--
I
S
E
G
Y
H
P
F
---------
G
K
S
L
Q
R
Q
--
A
N
I
L
L
G
A
C
N
L
--
D
C
F
H
--
S
--
D
K
H
E
D
V
I
---
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
Q
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
----
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
A
L
D
G
--
P
--
I
V
R
Q
L
E
R
G
G
-
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
L
R
K
F
R
T
Y
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
V
E
V
Q
E
T
L
G
S
I
P
D
D
F
V
R
Y
F
T
S
R
F
P
H
L
L
S
H
T
Y
Q
A
M
E
L
-
C
R
H
E
R
L
F
Q
T
Y
Y
----------------
34
Blastp_CBE
93.42
64%
-133
- C3 -
-
4PL4
1
D:
[20-419]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
V
I
V
G
K
I
S
F
C
P
K
D
V
L
G
H
G
A
-
E
G
T
I
V
Y
K
G
M
F
--
D
--
N
R
D
V
A
V
K
R
I
L
P
E
-----------
C
F
-----
S
F
A
D
R
E
V
Q
L
L
R
E
S
D
-------
E
H
P
N
V
--
I
R
Y
--
F
C
T
E
K
--
D
R
Q
------
F
Q
----
Y
I
A
I
E
L
C
-
A
-
A
T
L
Q
E
--
Y
V
E
Q
K
D
F
A
H
L
G
-----
L
E
--
P
I
--
T
----
L
L
H
Q
T
T
S
---
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
-
L
S
M
P
N
----
A
--------
H
G
R
I
--------
K
A
M
I
S
D
F
G
L
-
C
K
K
L
---------------
V
P
G
T
E
G
W
I
A
P
E
M
L
S
-----------------
P
T
---
Y
-
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
--
I
S
E
G
Y
H
P
F
---------
G
K
S
L
Q
R
Q
--
A
N
I
L
L
G
A
C
N
L
--
D
C
F
H
--
S
--
D
K
H
E
D
V
I
---
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
Q
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
----
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
--
E
A
L
D
G
--
P
--
I
V
R
Q
L
E
R
G
G
-
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
L
R
K
F
R
T
Y
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
V
E
V
Q
E
T
L
G
S
I
P
D
D
F
V
R
Y
F
T
S
R
F
P
H
L
L
S
H
T
Y
Q
A
M
E
L
-
C
---
R
L
F
Q
T
Y
Y
----------------
24
Blastp_CBE
93.40
66%
-121
- C3 -
-
3P23
1
ERN1_HUMAN
B:
[19-416]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
V
G
K
I
S
F
C
P
K
D
V
L
G
H
G
A
-
E
G
T
I
V
Y
R
G
M
F
--
D
--
N
R
D
V
A
V
K
R
I
L
P
E
-----------
C
F
-----
S
F
A
D
R
E
V
Q
L
L
R
E
S
D
-------
E
H
P
N
V
--
I
R
Y
--
F
C
T
E
K
--
D
R
Q
------
F
Q
----
Y
I
A
I
E
L
C
-
A
-
A
T
L
Q
E
--
Y
V
E
Q
K
D
F
A
H
L
G
-----
L
E
--
P
I
--
T
----
L
L
Q
Q
T
T
S
---
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
-
I
S
M
P
N
----
A
--------
H
G
K
I
--------
K
A
M
I
S
D
F
G
L
-
C
K
K
L
--
A
-------------
P
G
T
E
G
W
I
A
P
E
M
L
S
----
E
----------
E
N
P
T
---
Y
-
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
--
I
S
E
G
S
H
P
F
---------
G
K
S
L
Q
R
Q
--
A
N
I
L
L
G
A
C
S
L
--
D
C
L
H
--
P
--
E
K
H
E
D
V
I
---
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
K
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
----
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
S
L
D
G
--
P
--
I
V
K
Q
L
E
R
G
G
-
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
L
R
K
F
R
T
Y
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
A
E
V
R
E
T
L
G
T
L
P
D
D
F
V
C
Y
F
T
S
R
F
P
H
L
L
A
H
T
Y
R
A
M
E
L
-
C
S
H
E
R
L
F
Q
P
Y
Y
----------------
5
PsiBlast_PDB
93.37
66%
-133
- C3 -
-
4Z7G
-
ERN1_HUMAN
A:
[2-400]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
V
G
K
I
S
F
C
P
K
D
V
L
G
H
G
A
-
E
G
T
I
V
Y
R
G
M
F
--
D
--
N
R
D
V
A
V
K
R
I
L
P
E
-----------
C
F
-----
S
F
A
D
R
E
V
Q
L
L
R
E
S
D
-------
E
H
P
N
V
--
I
R
Y
--
F
C
T
E
K
--
D
R
Q
------
F
Q
----
Y
I
A
I
E
L
C
-
A
-
A
T
L
Q
E
--
Y
V
E
Q
K
D
F
A
H
L
G
-----
L
E
--
P
I
--
T
----
L
L
Q
Q
T
T
S
---
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
-
I
S
M
P
N
----
A
--------
H
G
K
I
--------
K
A
M
I
S
D
F
-----------------------
P
G
T
E
G
W
I
A
P
E
M
L
------------------
P
T
---
Y
-
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
--
I
S
E
G
S
H
P
F
---------
G
K
S
L
Q
R
Q
--
A
N
I
L
L
G
A
C
S
L
--
D
C
L
H
--
P
--
E
K
H
E
D
V
I
---
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
K
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
----
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
S
L
D
G
--
P
--
I
V
K
Q
L
E
R
G
G
-
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
----------
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
A
E
V
R
E
T
L
G
S
L
P
D
D
F
V
C
Y
F
T
S
R
F
P
H
L
L
A
H
T
Y
R
A
M
E
L
-
C
S
H
E
R
L
F
Q
P
Y
Y
----------------
10
PsiBlast_PDB
93.18
66%
-122
- C3 -
-
4YZD
1
ERN1_HUMAN
A:
[2-400]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
V
G
K
I
S
F
C
P
K
D
V
L
G
H
G
A
-
E
G
T
I
V
Y
R
G
M
F
--
D
--
N
R
D
V
A
V
K
R
I
L
P
E
-----------
C
F
-----
S
F
A
D
R
E
V
Q
L
L
R
E
S
D
-------
E
H
P
N
V
--
I
R
Y
--
F
C
T
E
K
--
D
R
Q
------
F
Q
----
Y
I
A
I
E
L
C
-
A
-
A
T
L
Q
E
--
Y
V
E
Q
K
D
F
A
H
L
G
-----
L
E
--
P
I
--
T
----
L
L
Q
Q
T
T
S
---
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
-
I
S
M
P
N
----
A
--------
H
G
K
I
--------
K
A
M
I
S
D
F
G
L
-
C
K
K
L
---------------
V
P
G
T
E
G
W
I
A
P
E
M
L
S
-----------------
P
T
---
Y
-
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
--
I
S
E
G
S
H
P
F
---------
G
K
S
L
Q
R
Q
--
A
N
I
L
L
G
A
C
S
L
--
D
C
L
H
--
P
--
E
K
H
E
D
V
I
---
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
K
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
----
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
S
L
D
G
--
P
--
I
V
K
Q
L
E
R
G
G
-
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
L
R
K
F
-
T
Y
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
A
E
V
R
E
T
L
G
S
L
P
D
D
F
V
C
Y
F
T
S
R
F
P
H
L
L
A
H
T
Y
R
A
M
E
L
-
C
S
H
E
R
L
F
Q
P
Y
Y
----------------
37
Blastp_CBE
92.95
64%
-125
- C3 -
-
4PL3
2
B:
[20-419]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
M
V
I
V
G
K
I
S
F
C
P
K
D
V
L
G
H
G
A
-
E
G
T
I
V
Y
K
G
M
F
--
D
--
N
R
D
V
A
V
K
R
I
L
P
E
-----------
C
F
-----
S
F
A
D
R
E
V
Q
L
L
R
E
S
D
-------
E
H
P
N
V
--
I
R
Y
--
F
C
T
E
K
--
D
R
Q
------
F
Q
----
Y
I
A
I
E
L
C
-
A
-
A
T
L
Q
E
--
Y
V
E
Q
K
D
F
A
H
L
G
-----
L
E
--
P
I
--
T
----
L
L
H
Q
T
T
S
---
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
-
L
S
M
P
N
----
A
--------
H
G
R
I
--------
K
A
M
I
S
D
F
G
L
-
C
K
K
----------------
V
P
G
T
E
G
W
I
A
P
E
M
L
S
-----------------
P
T
---
Y
-
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
--
I
S
E
G
Y
H
P
F
---------
G
K
S
L
Q
R
Q
--
A
N
I
L
L
G
A
C
N
L
--
D
C
F
H
--
S
--
D
K
H
E
D
V
I
---
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
Q
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
----
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
A
L
D
G
--
P
--
I
V
R
Q
L
E
R
G
G
-
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
L
R
K
F
R
T
Y
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
V
E
V
Q
E
T
L
G
S
I
P
D
D
F
V
R
Y
F
T
S
R
F
P
H
L
L
S
H
T
Y
Q
A
M
E
L
-
C
R
H
E
R
L
F
Q
T
Y
Y
----------------
31
Blastp_CBE
92.85
64%
-131
- C3 -
-
4PL5
1
D:
[19-419]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
M
V
I
V
G
K
I
S
F
C
P
K
D
V
L
G
H
G
A
-
E
G
T
I
V
Y
K
G
M
F
--
D
--
N
R
D
V
A
V
K
R
I
L
P
E
-----------
C
F
-----
S
F
A
D
R
E
V
Q
L
L
R
E
S
D
-------
E
H
P
N
V
--
I
R
Y
--
F
C
T
E
K
--
D
R
Q
------
F
Q
----
Y
I
A
I
E
L
C
-
A
-
A
T
L
Q
E
--
Y
V
E
Q
K
D
F
A
H
L
G
-----
L
E
--
P
I
--
T
----
L
L
H
Q
T
T
S
---
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
-
L
S
M
P
N
----
A
--------
H
G
R
I
--------
K
A
M
I
S
D
F
G
L
-
C
K
K
L
---------------
V
P
G
T
E
G
W
I
A
P
E
M
L
S
-----------------
P
T
---
Y
-
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
--
I
S
E
G
Y
H
P
F
---------
G
K
S
L
Q
R
Q
--
A
N
I
L
L
G
A
C
N
L
--
D
C
F
H
--
S
--
D
K
H
E
D
V
I
---
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
Q
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
----
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
A
L
D
G
--
P
--
I
V
R
Q
L
E
R
G
G
-
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
L
R
K
F
R
T
Y
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
V
E
V
Q
E
T
L
G
S
I
P
D
D
F
V
R
Y
F
T
S
R
F
P
H
L
L
S
H
T
Y
Q
A
M
E
L
-
C
R
H
E
R
L
F
Q
T
Y
Y
----------------
30
Blastp_CBE
92.81
66%
-129
- C3 -
-
4YZ9
1
ERN1_HUMAN
B:
[2-400]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
V
G
K
I
S
F
C
P
K
D
V
L
G
H
G
A
-
E
G
T
I
V
Y
R
G
M
F
--
D
--
N
R
D
V
A
V
K
R
I
L
P
E
-----------
C
F
-----
S
F
A
D
R
E
V
Q
L
L
R
E
S
D
-------
E
H
P
N
V
--
I
R
Y
--
F
C
T
E
K
--
D
R
Q
------
F
Q
----
Y
I
A
I
E
L
C
-
A
-
A
T
L
Q
E
--
Y
V
E
Q
K
D
F
A
H
L
G
-----
L
E
--
P
I
--
T
----
L
L
Q
Q
T
T
S
---
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
-
I
S
M
P
N
----
A
--------
H
G
K
I
--------
K
A
M
I
S
D
F
G
L
-
C
----------------------
E
G
W
I
A
P
E
M
L
S
----------------
N
P
T
---
Y
-
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
--
I
S
E
G
S
H
P
F
---------
G
K
S
L
Q
R
Q
--
A
N
I
L
L
G
A
C
S
L
--
D
C
L
H
--
P
--
E
K
H
E
D
V
I
---
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
K
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
----
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
S
L
D
G
--
P
--
I
V
K
Q
L
E
R
G
G
-
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
L
--
F
R
T
Y
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
A
E
V
R
E
T
L
G
S
L
P
D
D
F
V
C
Y
F
T
S
R
F
P
H
L
L
A
H
T
Y
R
A
M
E
L
-
C
S
H
E
R
L
F
Q
P
Y
Y
----------------
7
PsiBlast_PDB
91.87
66%
-116
- C3 -
-
6HV0
1
A:
[2-400]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
V
G
K
I
S
F
C
P
K
D
V
L
G
H
G
A
-
E
G
T
I
V
Y
R
G
M
F
--
D
--
N
R
D
V
A
V
K
R
I
L
P
E
-----------
C
------------------
S
D
-------
E
H
P
N
V
--
I
R
Y
--
F
C
T
E
K
--
D
R
Q
------
F
Q
----
Y
I
A
I
E
L
C
-
A
-
A
T
L
Q
E
--
Y
V
E
Q
K
D
F
---
G
-----
L
E
--
P
I
--
T
----
L
L
Q
Q
T
T
S
---
G
L
A
H
L
H
S
L
N
I
V
H
R
D
L
K
P
H
N
I
L
-
I
S
M
P
N
----
A
--------
H
G
K
I
--------
K
A
M
I
S
D
F
G
L
-
C
K
K
L
--
A
V
G
R
H
S
F
-
S
R
R
S
G
V
P
G
T
E
G
W
I
A
P
E
M
------------------
N
P
T
---
Y
-
T
V
D
I
F
S
A
G
C
V
F
Y
Y
V
--
I
S
E
G
S
H
P
F
---------
G
K
S
L
Q
R
Q
--
A
N
I
L
L
G
A
C
S
L
--
D
C
L
H
--
P
--
E
K
H
E
D
V
I
---
A
R
E
L
I
E
K
M
I
A
M
D
P
Q
K
R
P
S
A
K
H
V
L
K
H
P
F
F
W
S
----
L
E
K
Q
L
Q
F
F
Q
D
V
S
D
R
I
E
K
E
S
L
D
G
--
P
--
I
V
K
Q
L
E
R
G
G
-
R
A
V
V
-
K
M
-
D
W
R
E
N
I
T
V
P
L
Q
T
D
L
R
--
R
T
Y
K
G
G
S
V
R
D
L
L
R
A
M
R
N
K
K
H
H
Y
R
E
L
P
A
E
V
R
E
T
L
G
S
L
P
D
D
F
V
C
Y
F
T
S
R
F
P
H
L
L
A
H
T
Y
R
A
M
E
L
-
C
S
H
E
R
L
F
Q
P
Y
Y
----------------
200
HHSearch
70.36
42%
-23
- C3 -
-
3LJ0
3
B:
[16-431]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
V
S
E
K
I
L
G
Y
G
S
-
S
G
T
V
V
F
Q
G
S
F
--
Q
--
G
R
P
V
A
V
K
R
M
L
I
D
-----------
F
C
-----
D
I
A
L
M
E
I
K
L
L
T
E
S
D
-------
D
H
P
N
V
--
I
R
Y
--
Y
C
S
E
T
--
T
D
R
------
F
L
----
Y
I
A
L
E
L
C
-
N
-
L
N
L
Q
D
--
L
V
E
S
------------
Y
N
--
P
I
--
S
----
L
L
R
Q
I
A
S
---
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
-
V
S
T
S
S
----
R
FTADQQTG
A
E
N
L
--------
R
I
L
I
S
D
F
G
L
-
C
K
K
L
--
D
S
G
Q
S
S
F
R
T
-------
T
S
G
W
R
A
P
E
L
L
E
----
E
S
---
N
NLQT
K
R
R
L
T
---
R
-
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
--
L
S
K
G
K
H
P
F
---------
G
D
K
Y
S
R
E
--
S
N
I
I
R
G
I
F
S
L
--
D
E
M
K
CL
H
--
D
R
S
L
I
A
E
---
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
R
P
T
A
M
K
V
L
R
H
P
L
F
W
P
----
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
E
N
R
D
P
PS
A
--
L
L
M
K
F
D
A
G
S
D
F
V
I
P
-
S
G
-
D
W
T
V
K
F
D
K
T
F
M
D
N
L
E
R
Y
R
K
Y
H
S
S
K
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
M
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
F
P
N
L
L
I
G
V
Y
M
I
V
K
E
N
L
S
D
D
Q
I
L
R
E
F
-----------------
216
Fugue
68.56
43%
-18
- C3 -
-
2RIO
1
IRE1_YEAST
A:
[8-434]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
E
Q
S
L
K
N
L
V
V
S
E
K
I
L
G
Y
G
S
-
S
G
T
V
V
F
Q
G
S
F
--
Q
--
G
R
P
V
A
V
K
R
M
L
I
D
-----------
F
C
-----
D
I
A
L
M
E
I
K
L
L
T
E
S
D
-------
D
H
P
N
V
--
I
R
Y
--
Y
C
S
E
T
--
T
D
R
------
F
L
----
Y
I
A
L
E
L
C
-
N
-
L
N
L
Q
D
--
L
V
E
S
K
Y
-----------
N
--
P
I
--
S
----
L
L
R
Q
I
A
S
---
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
-
V
S
T
S
S
----
R
--------
F
T
A
D
QQTGAENL
R
I
L
I
S
D
F
G
L
-
C
K
K
L
--
D
--------------
S
T
S
G
W
R
A
P
E
L
L
E
ESNN
L
Q
---
T
----
K
R
R
L
T
---
R
-
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
--
L
S
K
G
K
H
P
F
---------
G
D
K
Y
S
R
E
--
S
N
I
I
R
G
I
F
S
L
--
D
E
M
K
--
C
LH
D
R
S
L
I
A
E
---
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
R
P
T
A
M
K
V
L
R
H
P
L
F
W
P
----
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
E
N
R
D
P
--
P
SA
L
L
M
K
F
D
A
G
S
-
D
F
V
I
-
P
S
G
D
W
T
V
K
F
D
K
T
F
M
D
-----
R
K
Y
H
S
S
K
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
M
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
F
P
N
L
L
I
G
V
Y
M
I
V
K
E
N
L
S
D
D
Q
I
L
R
E
F
L
Y
S
--------------
199
HHSearch
68.42
42%
-15
- C3 -
-
2RIO
1
B:
[16-431]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
V
S
E
K
I
L
G
Y
G
S
-
S
G
T
V
V
F
Q
G
S
F
--
Q
--
G
R
P
V
A
V
K
R
M
L
I
D
-----------
F
C
-----
D
I
A
L
M
E
I
K
L
L
T
E
S
D
-------
D
H
P
N
V
--
I
R
Y
--
Y
C
S
E
T
--
T
D
R
------
F
L
----
Y
I
A
L
E
L
C
-
N
-
L
N
L
Q
D
--
L
V
E
S
------------
Y
N
--
P
I
--
S
----
L
L
R
Q
I
A
S
---
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
-
V
S
T
S
S
----
R
FTADQQTG
A
E
N
L
--------
R
I
L
I
S
D
F
G
L
-
C
K
K
L
--
D
S
--------------
T
S
G
W
R
A
P
E
L
L
E
----
E
S
---
N
NLQT
K
R
R
L
T
---
R
-
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
--
L
S
K
G
K
H
P
F
---------
G
D
K
Y
S
R
E
--
S
N
I
I
R
G
I
F
S
L
--
D
E
M
K
CL
H
--
D
R
S
L
I
A
E
---
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
R
P
T
A
M
K
V
L
R
H
P
L
F
W
P
----
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
E
N
R
D
P
PS
A
--
L
L
M
K
F
D
A
G
S
D
F
V
I
P
-
S
G
-
D
W
T
V
K
F
D
K
T
F
M
D
-----
R
K
Y
H
S
S
K
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
M
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
F
P
N
L
L
I
G
V
Y
M
I
V
K
E
N
L
S
D
D
Q
I
L
R
E
F
-----------------
20
PsiBlast_PDB
66.78
43%
11
- C3 -
-
3LJ2
1
IRE1_YEAST
A:
[22-428]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
G
Y
G
S
-
S
G
T
V
V
F
Q
G
S
F
--
Q
--
G
R
P
V
A
V
K
R
M
L
I
D
-----------
F
C
-----
D
I
A
L
M
E
I
K
L
L
T
E
S
D
-------
D
H
P
N
V
--
I
R
Y
--
Y
C
S
E
T
--
T
D
R
------
F
L
----
Y
I
A
L
E
L
C
-
N
-
L
N
L
Q
D
--
L
V
E
S
--------------YN
P
I
--
S
----
L
L
R
Q
I
A
S
---
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
-
V
S
T
S
S
RFTA
D
--------
Q
Q
T
G
AENL----
R
I
L
I
S
D
F
G
L
-
C
K
K
L
--
D
S
G
Q
S
S
F
-
R
T
------
T
S
G
W
R
A
P
E
L
L
E
ESNN
L
Q
---
T
----
K
R
R
L
T
---
R
-
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
--
L
S
K
G
K
H
P
F
---------
G
D
K
Y
S
R
E
--
S
N
I
I
R
G
I
F
S
L
--
D
E
M
---
K
--
C
L
H
D
R
S
L
IAE
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
R
P
T
A
M
K
V
L
R
H
P
L
F
W
P
----
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
E
N
R
D
P
--
P
SA
L
L
M
K
F
D
A
G
S
-
D
F
V
I
P
S
G
-
D
W
T
V
K
F
D
K
T
F
M
D
N
L
E
R
Y
R
K
Y
H
S
S
K
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
M
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
F
P
N
L
L
I
G
V
Y
M
I
V
K
E
-
N
L
S
D
D
Q
I
L
-------------------
18
PsiBlast_PDB
66.41
43%
12
- C3 -
-
3LJ0
3
IRE1_YEAST
A:
[22-428]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
G
Y
G
S
-
S
G
T
V
V
F
Q
G
S
F
--
Q
--
G
R
P
V
A
V
K
R
M
L
I
D
-----------
F
C
-----
D
I
A
L
M
E
I
K
L
L
T
E
S
D
-------
D
H
P
N
V
--
I
R
Y
--
Y
C
S
E
T
--
T
D
R
------
F
L
----
Y
I
A
L
E
L
C
-
N
-
L
N
L
Q
D
--
L
V
E
S
--------------YN
P
I
--
S
----
L
L
R
Q
I
A
S
---
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
-
V
S
T
S
S
RFTA
D
--------
Q
Q
T
G
AENL----
R
I
L
I
S
D
F
G
L
-
C
K
K
L
--
D
S
G
Q
S
S
F
-
R
T
------
T
S
G
W
R
A
P
E
L
L
E
ESNN
L
Q
---
T
----
K
R
R
L
T
---
R
-
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
--
L
S
K
G
K
H
P
F
---------
G
D
K
Y
S
R
E
--
S
N
I
I
R
G
I
F
S
L
--
D
E
M
---
K
--
C
L
H
D
R
S
L
IAE
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
R
P
T
A
M
K
V
L
R
H
P
L
F
W
P
----
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
E
N
R
D
P
--
P
SA
L
L
M
K
F
D
A
G
S
-
D
F
V
I
P
S
G
-
D
W
T
V
K
F
D
K
T
F
M
D
N
L
E
R
Y
R
K
Y
H
S
S
K
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
M
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
F
P
N
L
L
I
G
V
Y
M
I
V
K
E
-
N
L
S
D
D
Q
I
L
-------------------
55
Blastp_CBE
66.36
43%
14
- C3 -
-
3LJ0
3
B:
[22-428]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
G
Y
G
S
-
S
G
T
V
V
F
Q
G
S
F
--
Q
--
G
R
P
V
A
V
K
R
M
L
I
D
-----------
F
C
-----
D
I
A
L
M
E
I
K
L
L
T
E
S
D
-------
D
H
P
N
V
--
I
R
Y
--
Y
C
S
E
T
--
T
D
R
------
F
L
----
Y
I
A
L
E
L
C
-
N
-
L
N
L
Q
D
--
L
V
E
S
--------------YN
P
I
--
S
----
L
L
R
Q
I
A
S
---
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
-
V
S
T
S
S
RFTA
D
--------
Q
Q
T
G
AENL----
R
I
L
I
S
D
F
G
L
-
C
K
K
L
--
D
S
G
Q
S
S
F
-
R
N
------
T
S
G
W
R
A
P
E
L
L
E
ESNN
L
Q
---
T
----
K
R
R
L
T
---
R
-
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
--
L
S
K
G
K
H
P
F
---------
G
D
K
Y
S
R
E
--
S
N
I
I
R
G
I
F
S
L
--
D
E
M
---
K
--
C
L
H
D
R
S
L
IAE
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
R
P
T
A
M
K
V
L
R
H
P
L
F
W
P
----
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
E
N
R
D
P
--
P
SA
L
L
M
K
F
D
A
G
S
-
D
F
V
I
P
S
G
-
D
W
T
V
K
F
D
K
T
F
M
D
N
L
E
R
Y
R
K
Y
H
S
S
K
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
M
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
F
P
N
L
L
I
G
V
Y
M
I
V
K
E
-
N
L
S
D
D
Q
I
L
-------------------
19
PsiBlast_PDB
65.70
43%
15
- C3 -
-
3LJ1
1
IRE1_YEAST
A:
[22-428]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
G
Y
G
S
-
S
G
T
V
V
F
Q
G
S
F
--
Q
--
G
R
P
V
A
V
K
R
M
L
I
D
-----------
F
C
-----
D
I
A
L
M
E
I
K
L
L
T
E
S
D
-------
D
H
P
N
V
--
I
R
Y
--
Y
C
S
E
T
--
T
D
R
------
F
L
----
Y
I
A
L
E
L
C
-
N
-
L
N
L
Q
D
--
L
V
E
S
--------------YN
P
I
--
S
----
L
L
R
Q
I
A
S
---
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
-
V
S
T
S
S
RFTA
D
--------
Q
Q
T
G
AENL----
R
I
L
I
S
D
F
G
L
-
C
K
K
L
--
D
S
G
Q
S
S
F
-
R
T
------
T
S
G
W
R
A
P
E
L
L
E
ESNN
L
Q
---
T
----
K
R
R
L
T
---
R
-
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
--
L
S
K
G
K
H
P
F
---------
G
D
K
Y
S
R
E
--
S
N
I
I
R
G
I
F
S
L
--
D
E
M
---
K
--
C
L
H
D
R
S
L
IAE
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
R
P
T
A
M
K
V
L
R
H
P
L
F
W
P
----
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
E
N
R
D
P
--
P
SA
L
L
M
K
F
D
A
G
S
-
D
F
V
I
P
S
G
-
D
W
T
V
K
F
D
K
T
F
M
D
N
L
E
R
Y
R
K
Y
H
S
S
K
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
M
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
F
P
N
L
L
I
G
V
Y
M
I
V
K
E
-
N
L
S
D
D
Q
I
L
-------------------
39
Blastp_CBE
65.34
43%
16
- C3 -
-
2RIO
1
B:
[22-428]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
G
Y
G
S
-
S
G
T
V
V
F
Q
G
S
F
--
Q
--
G
R
P
V
A
V
K
R
M
L
I
D
-----------
F
C
-----
D
I
A
L
M
E
I
K
L
L
T
E
S
D
-------
D
H
P
N
V
--
I
R
Y
--
Y
C
S
E
T
--
T
D
R
------
F
L
----
Y
I
A
L
E
L
C
-
N
-
L
N
L
Q
D
--
L
V
E
S
--------------YN
P
I
--
S
----
L
L
R
Q
I
A
S
---
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
-
V
S
T
S
S
RFTA
D
--------
Q
Q
T
G
AENL----
R
I
L
I
S
D
F
G
L
-
C
K
K
L
--
D
S
--------------
T
S
G
W
R
A
P
E
L
L
E
ESNN
L
Q
---
T
----
K
R
R
L
T
---
R
-
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
--
L
S
K
G
K
H
P
F
---------
G
D
K
Y
S
R
E
--
S
N
I
I
R
G
I
F
S
L
--
D
E
M
---
K
--
C
L
H
D
R
S
L
IAE
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
R
P
T
A
M
K
V
L
R
H
P
L
F
W
P
----
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
E
N
R
D
P
--
P
SA
L
L
M
K
F
D
A
G
S
-
D
F
V
I
P
S
G
-
D
W
T
V
K
F
D
K
T
F
M
D
-----
R
K
Y
H
S
S
K
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
M
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
F
P
N
L
L
I
G
V
Y
M
I
V
K
E
-
N
L
S
D
D
Q
I
L
-------------------
54
Blastp_CBE
65.24
43%
18
- C3 -
-
3LJ1
1
B:
[22-428]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
G
Y
G
S
-
S
G
T
V
V
F
Q
G
S
F
--
Q
--
G
R
P
V
A
V
K
R
M
L
I
D
-----------
F
C
-----
D
I
A
L
M
E
I
K
L
L
T
E
S
D
-------
D
H
P
N
V
--
I
R
Y
--
Y
C
S
E
T
--
T
D
R
------
F
L
----
Y
I
A
L
E
L
C
-
N
-
L
N
L
Q
D
--
L
V
E
S
--------------YN
P
I
--
S
----
L
L
R
Q
I
A
S
---
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
-
V
S
T
S
S
RFTA
D
--------
Q
Q
T
G
AENL----
R
I
L
I
S
D
F
G
L
-
C
K
K
L
--
D
S
G
Q
S
S
F
-
R
N
------
T
S
G
W
R
A
P
E
L
L
E
ESNN
L
Q
---
T
----
K
R
R
L
T
---
R
-
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
--
L
S
K
G
K
H
P
F
---------
G
D
K
Y
S
R
E
--
S
N
I
I
R
G
I
F
S
L
--
D
E
M
---
K
--
C
L
H
D
R
S
L
IAE
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
R
P
T
A
M
K
V
L
R
H
P
L
F
W
P
----
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
E
N
R
D
P
--
P
SA
L
L
M
K
F
D
A
G
S
-
D
F
V
I
P
S
G
-
D
W
T
V
K
F
D
K
T
F
M
D
N
L
E
R
Y
R
K
Y
H
S
S
K
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
M
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
F
P
N
L
L
I
G
V
Y
M
I
V
K
E
-
N
L
S
D
D
Q
I
L
-------------------
53
Blastp_CBE
65.06
43%
14
- C3 -
-
3LJ2
1
B:
[22-428]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
G
Y
G
S
-
S
G
T
V
V
F
Q
G
S
F
--
Q
--
G
R
P
V
A
V
K
R
M
L
I
D
-----------
F
C
-----
D
I
A
L
M
E
I
K
L
L
T
E
S
D
-------
D
H
P
N
V
--
I
R
Y
--
Y
C
S
E
T
--
T
D
R
------
F
L
----
Y
I
A
L
E
L
C
-
N
-
L
N
L
Q
D
--
L
V
E
S
--------------YN
P
I
--
S
----
L
L
R
Q
I
A
S
---
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
-
V
S
T
S
S
RFTA
D
--------
Q
Q
T
G
AENL----
R
I
L
I
S
D
F
G
L
-
C
K
K
L
--
D
S
G
Q
S
S
F
-
R
N
------
T
S
G
W
R
A
P
E
L
L
E
ESNN
L
Q
---
T
----
K
R
R
L
T
---
R
-
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
--
L
S
K
G
K
H
P
F
---------
G
D
K
Y
S
R
E
--
S
N
I
I
R
G
I
F
S
L
--
D
E
M
---
K
--
C
L
H
D
R
S
L
IAE
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
R
P
T
A
M
K
V
L
R
H
P
L
F
W
P
----
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
E
N
R
D
P
--
P
SA
L
L
M
K
F
D
A
G
S
-
D
F
V
I
P
S
G
-
D
W
T
V
K
F
D
K
T
F
M
D
N
L
E
R
Y
R
K
Y
H
S
S
K
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
M
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
F
P
N
L
L
I
G
V
Y
M
I
V
K
E
-
N
L
S
D
D
Q
I
L
-------------------
15
PsiBlast_PDB
64.83
43%
13
- C3 -
-
2RIO
1
IRE1_YEAST
A:
[22-428]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
G
Y
G
S
-
S
G
T
V
V
F
Q
G
S
F
--
Q
--
G
R
P
V
A
V
K
R
M
L
I
D
-----------
F
C
-----
D
I
A
L
M
E
I
K
L
L
T
E
S
D
-------
D
H
P
N
V
--
I
R
Y
--
Y
C
S
E
T
--
T
D
R
------
F
L
----
Y
I
A
L
E
L
C
-
N
-
L
N
L
Q
D
--
L
V
E
S
K
-------------YN
P
I
--
S
----
L
L
R
Q
I
A
S
---
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
-
V
S
T
S
S
RFTA
D
--------
Q
Q
T
G
AENL----
R
I
L
I
S
D
F
G
L
-
C
K
K
L
--
D
S
--------------
T
S
G
W
R
A
P
E
L
L
E
ESNN
L
Q
---
T
----
K
R
R
L
T
---
R
-
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
--
L
S
K
G
K
H
P
F
---------
G
D
K
Y
S
R
E
--
S
N
I
I
R
G
I
F
S
L
--
D
E
M
---
K
--
C
L
H
D
R
S
L
IAE
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
R
P
T
A
M
K
V
L
R
H
P
L
F
W
P
----
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
E
N
R
D
P
--
P
SA
L
L
M
K
F
D
A
G
S
-
D
F
V
I
P
S
G
-
D
W
T
V
K
F
D
K
T
F
M
D
-----
R
K
Y
H
S
S
K
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
M
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
F
P
N
L
L
I
G
V
Y
M
I
V
K
E
-
N
L
S
D
D
Q
I
L
-------------------
95
Blastp_CBE
40.94
32%
-9
- C3 -
-
5VCW
2
PMYT1_HUMAN
B:
[26-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
P
R
R
V
S
F
R
G
E
A
S
E
T
L
Q
S
P
G
Y
D
P
S
R
P
E
S
F
F
--
Q
Q
S
F
Q
R
L
S
R
L
G
H
G
S
Y
G
E
V
F
K
V
R
S
K
E
--
D
--
G
R
L
Y
A
V
K
R
S
M
S
P
-----------
F
R
-----
G
P
K
D
R
-
A
R
K
L
A
E
V
G
-------
S
H
E
K
V
--
G
Q
H
--
P
C
C
V
R
--
L
E
Q
AWEEGG
I
L
----
Y
L
Q
T
E
L
C
-
G
-
P
S
L
Q
Q
--
H
C
E
A
----
W
G
A
-----
S
L
--
P
E
--
A
QVWG
Y
L
R
D
T
L
L
---
A
L
A
H
L
H
S
Q
G
L
V
H
L
D
V
K
P
A
N
I
F
-
L
-
G
P
R
----------------
G
--------
R
C
K
L
G
D
F
G
L
-
L
V
E
L
--
G
T
A
G
A
G
--
E
V
Q
E
G
D
P
---
R
Y
M
A
P
E
L
L
Q
---------------
G
S
Y
G
---
T
-
A
A
D
V
F
S
L
G
L
T
I
L
E
V
--
A
C
N
M
E
L
P
H
---------
G
G
E
G
W
Q
Q
--
L
R
Q
G
Y
L
P
P
E
F
T-
A
G
L
S
--
S
--
E
L
---------
R
S
V
L
V
M
M
L
E
P
D
P
K
L
R
A
T
A
E
A
L
L
A
L
P
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
215
HHSearch
40.58
30%
-17
- C3 -
-
2Y7J
1
PHKG2_HUMAN
A:
[95-364]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
D
P
K
D
V
I
G
R
G
V
-
S
S
V
-
V
R
R
C
V
H
RA
T
--
G
H
E
F
A
V
K
I
M
E
V
T
AERLSPEQLEE
V
R
-----
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
-------
G
H
P
H
I
--
I
T
L
--
I
D
S
Y
E
--
S
S
S
------
F
M
----
F
L
V
F
D
L
M
-
R
K
G
E
L
F
D
--
Y
L
T
E
K
V
A
-
L
S
E
-----
K
E
--
T
R
--
S
----
I
M
R
S
L
L
E
---
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
-
L
D
D
N
-----------------
M
--------
Q
I
R
L
S
D
F
G
F
-
S
C
H
L
--
E
P
G
E
-----
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
----
C
S
MDE
T
----
H
P
G
Y
G
---
K
-
E
V
D
L
W
A
C
G
V
I
L
F
T
L
--
L
A
-
G
S
P
P
F
---------
W
H
R
R
Q
I
L
ML
R
M
I
M
E
G
Q
Y
Q
F
--
S
-
S
P
--
E
--
W
D
D
R
S
S
T
---
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
------------------------------------------------------------------------------------------------------------------------------------------------------------
209
HHSearch
40.57
30%
-26
- C3 -
-
5VCZ
7
PMYT1_HUMAN
A:
[58-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
Q
R
L
S
R
L
G
H
G
S
-
Y
G
E
-
V
F
K
V
R
S
KE
D
--
G
R
L
Y
A
V
K
R
S
M
S
P
-----------
F
R
GPKDR
A
R
K
L
A
E
V
G
S
H
E
K
V
G
-------
Q
H
P
C
C
--
V
R
L
--
E
Q
A
W
E
--
E
G
G
------
I
L
----
Y
L
Q
T
E
L
C
-
G
-
P
S
L
Q
Q
--
H
C
E
A
W
G
A
S
L
P
E
-----
A
Q
--
V
W
--
G
----
Y
L
R
D
T
L
L
---
A
L
A
H
L
H
S
Q
G
L
V
H
L
D
V
K
P
A
N
I
F
-
L
G
P
R
-----------------
G
--------
R
C
K
L
G
D
F
G
L
-
L
V
E
L
--
G
T
A
G
A
-----
G
E
V
Q
E
G
D
P
R
Y
M
A
P
E
L
L
Q
----
G
-----------
S
Y
G
---
T
-
A
A
D
V
F
S
L
G
L
T
I
L
E
V
--
A
C
N
M
-
E
L
P
---------
H
G
G
E
G
W
---
Q
Q
L
R
Q
G
Y
L
P
---
P
E
F
T
--
A
----
G
L
S
S
E
---
L
R
S
V
L
V
M
M
L
E
P
D
P
K
L
R
A
T
A
E
A
L
L
A
L
P
V
L
R
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
90
Blastp_CBE
40.28
32%
-6
- C3 -
-
5VD1
2
PMYT1_HUMAN
A:
[18-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
H
Q
L
Q
P
R
R
V
S
F
R
G
E
A
S
E
T
L
Q
S
P
G
Y
D
P
S
R
P
E
S
F
F
--
Q
Q
S
F
Q
R
L
S
R
L
G
H
G
S
Y
G
E
V
F
K
V
R
S
K
E
--
D
--
G
R
L
Y
A
V
K
R
S
M
S
P
-----------
F
R
-----
G
P
K
D
R
-
A
R
K
L
A
E
V
G
-------
S
H
E
K
V
--
G
Q
H
--
P
C
C
V
R
--
L
E
Q
AWEEGG
I
L
----
Y
L
Q
T
E
L
C
-
G
-
P
S
L
Q
Q
--
H
C
E
A
----
W
G
A
-----
S
L
--
P
E
--
A
QVWG
Y
L
R
D
T
L
L
---
A
L
A
H
L
H
S
Q
G
L
V
H
L
D
V
K
P
A
N
I
F
-
L
-
G
P
R
----------------
G
--------
R
C
K
L
G
D
F
G
L
-
L
V
E
L
--
G
T
A
G
A
G
--
E
V
Q
E
G
D
P
---
R
Y
M
A
P
E
L
L
Q
---------------
G
S
Y
G
---
T
-
A
A
D
V
F
S
L
G
L
T
I
L
E
V
--
A
C
N
M
E
L
P
H
---------
G
G
E
G
W
Q
Q
--
L
R
Q
G
Y
L
P
P
E
F
T-
A
G
L
S
--
S
--
E
L
---------
R
S
V
L
V
M
M
L
E
P
D
P
K
L
R
A
T
A
E
A
L
L
A
L
P
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
94
Blastp_CBE
40.07
32%
-3
- C3 -
-
5VCX
2
PMYT1_HUMAN
A:
[24-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
L
Q
P
R
R
V
S
F
R
G
E
A
S
E
T
L
Q
S
P
G
Y
D
P
S
R
P
E
S
F
F
--
Q
Q
S
F
Q
R
L
S
R
L
G
H
G
S
Y
G
E
V
F
K
V
R
S
K
E
--
D
--
G
R
L
Y
A
V
K
R
S
M
S
P
-----------
F
R
-----
G
P
K
D
R
-
A
R
K
L
A
E
V
G
-------
S
H
E
K
V
--
G
Q
H
--
P
C
C
V
R
--
L
E
Q
AWEEGG
I
L
----
Y
L
Q
T
E
L
C
-
G
-
P
S
L
Q
Q
--
H
C
E
A
----
W
G
A
-----
S
L
--
P
E
--
A
QVWG
Y
L
R
D
T
L
L
---
A
L
A
H
L
H
S
Q
G
L
V
H
L
D
V
K
P
A
N
I
F
-
L
-
G
P
R
----------------
G
--------
R
C
K
L
G
D
F
G
L
-
L
V
E
L
--
G
T
A
G
A
G
--
E
V
Q
E
G
D
P
---
R
Y
M
A
P
E
L
L
Q
---------------
G
S
Y
G
---
T
-
A
A
D
V
F
S
L
G
L
T
I
L
E
V
--
A
C
N
M
E
L
P
H
---------
G
G
E
G
W
Q
Q
--
L
R
Q
G
Y
L
P
P
E
F
T-
A
G
L
S
--
S
--
E
L
---------
R
S
V
L
V
M
M
L
E
P
D
P
K
L
R
A
T
A
E
A
L
L
A
L
P
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
208
HHSearch
39.82
30%
-28
- C3 -
-
5VCY
6
PMYT1_HUMAN
A:
[58-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
Q
R
L
S
R
L
G
H
G
S
-
Y
G
E
-
V
F
K
V
R
S
KE
D
--
G
R
L
Y
A
V
K
R
S
M
S
P
-----------
F
R
GPKDR
A
R
K
L
A
E
V
G
S
H
E
K
V
G
-------
Q
H
P
C
C
--
V
R
L
--
E
Q
A
W
E
--
E
G
G
------
I
L
----
Y
L
Q
T
E
L
C
-
G
-
P
S
L
Q
Q
--
H
C
E
A
W
G
A
S
L
P
E
-----
A
Q
--
V
W
--
G
----
Y
L
R
D
T
L
L
---
A
L
A
H
L
H
S
Q
G
L
V
H
L
D
V
K
P
A
N
I
F
-
L
G
P
R
-----------------
G
--------
R
C
K
L
G
D
F
G
L
-
L
V
E
L
--
G
T
A
G
A
-----
G
E
V
Q
E
G
D
P
R
Y
M
A
P
E
L
L
Q
----
G
-----------
S
Y
G
---
T
-
A
A
D
V
F
S
L
G
L
T
I
L
E
V
--
A
C
N
M
-
E
L
P
---------
H
G
G
E
G
W
---
Q
Q
L
R
Q
G
Y
L
P
---
P
E
F
T
--
A
----
G
L
S
S
E
---
L
R
S
V
L
V
M
M
L
E
P
D
P
K
L
R
A
T
A
E
A
L
L
A
L
P
V
L
R
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
89
Blastp_CBE
39.13
32%
-3
- C3 -
-
5VD3
4
PMYT1_HUMAN
A:
[16-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
H
Q
L
Q
P
R
R
V
S
F
R
G
E
A
S
E
T
L
Q
S
P
G
Y
D
P
S
R
P
E
S
F
F
--
Q
Q
S
F
Q
R
L
S
R
L
G
H
G
S
Y
G
E
V
F
K
V
R
S
K
E
--
D
--
G
R
L
Y
A
V
K
R
S
M
S
P
-----------
F
R
-----
G
P
K
D
R
-
A
R
K
L
A
E
V
G
-------
S
H
E
K
V
--
G
Q
H
--
P
C
C
V
R
--
L
E
Q
AWEEGG
I
L
----
Y
L
Q
T
E
L
C
-
G
-
P
S
L
Q
Q
--
H
C
E
A
----
W
G
A
-----
S
L
--
P
E
--
A
QVWG
Y
L
R
D
T
L
L
---
A
L
A
H
L
H
S
Q
G
L
V
H
L
D
V
K
P
A
N
I
F
-
L
-
G
P
R
----------------
G
--------
R
C
K
L
G
D
F
G
L
-
L
V
E
L
--
G
T
A
G
A
G
--
E
V
Q
E
G
D
P
---
R
Y
M
A
P
E
L
L
Q
---------------
G
S
Y
G
---
T
-
A
A
D
V
F
S
L
G
L
T
I
L
E
V
--
A
C
N
M
E
L
P
H
---------
G
G
E
G
W
Q
Q
--
L
R
Q
G
Y
L
P
P
E
F
T-
A
G
L
S
--
S
--
E
L
---------
R
S
V
L
V
M
M
L
E
P
D
P
K
L
R
A
T
A
E
A
L
L
A
L
P
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
38.85
32%
-0
- C3 -
-
5VD0
2
PMYT1_HUMAN
A:
[16-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
H
Q
L
Q
P
R
R
V
S
F
R
G
E
A
S
E
T
L
Q
S
P
G
Y
D
P
S
R
P
E
S
F
F
--
Q
Q
S
F
Q
R
L
S
R
L
G
H
G
S
Y
G
E
V
F
K
V
R
S
K
E
--
D
--
G
R
L
Y
A
V
K
R
S
M
S
P
-----------
F
R
-----
G
P
K
D
R
-
A
R
K
L
A
E
V
G
-------
S
H
E
K
V
--
G
Q
H
--
P
C
C
V
R
--
L
E
Q
AWEEGG
I
L
----
Y
L
Q
T
E
L
C
-
G
-
P
S
L
Q
Q
--
H
C
E
A
----
W
G
A
-----
S
L
--
P
E
--
A
QVWG
Y
L
R
D
T
L
L
---
A
L
A
H
L
H
S
Q
G
L
V
H
L
D
V
K
P
A
N
I
F
-
L
-
G
P
R
----------------
G
--------
R
C
K
L
G
D
F
G
L
-
L
V
E
L
--
G
T
A
G
A
G
--
E
V
Q
E
G
D
P
---
R
Y
M
A
P
E
L
L
Q
---------------
G
S
Y
G
---
T
-
A
A
D
V
F
S
L
G
L
T
I
L
E
V
--
A
C
N
M
E
L
P
H
---------
G
G
E
G
W
Q
Q
--
L
R
Q
G
Y
L
P
P
E
F
T-
A
G
L
S
--
S
--
E
L
---------
R
S
V
L
V
M
M
L
E
P
D
P
K
L
R
A
T
A
E
A
L
L
A
L
P
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
37.93
32%
-2
- C3 -
-
5VCW
5
PMYT1_HUMAN
A:
[26-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
P
R
R
V
S
F
R
G
E
A
S
E
T
L
Q
S
P
G
Y
D
P
S
R
P
E
S
F
F
--
Q
Q
S
F
Q
R
L
S
R
L
G
H
G
S
Y
G
E
V
F
K
V
R
S
K
E
--
D
--
G
R
L
Y
A
V
K
R
S
M
S
P
-----------
F
R
-----
G
P
K
D
R
-
A
R
K
L
A
E
V
G
-------
S
H
E
K
V
--
G
Q
H
--
P
C
C
V
R
--
L
E
Q
AWEEGG
I
L
----
Y
L
Q
T
E
L
C
-
G
-
P
S
L
Q
Q
--
H
C
E
A
----
W
G
A
-----
S
L
--
P
E
--
A
QVWG
Y
L
R
D
T
L
L
---
A
L
A
H
L
H
S
Q
G
L
V
H
L
D
V
K
P
A
N
I
F
-
L
-
G
P
R
----------------
G
--------
R
C
K
L
G
D
F
G
L
-
L
V
E
L
--
G
T
A
G
A
G
--
E
V
Q
E
G
D
P
---
R
Y
M
A
P
E
L
L
Q
---------------
G
S
Y
G
---
T
-
A
A
D
V
F
S
L
G
L
T
I
L
E
V
--
A
C
N
M
E
L
P
H
---------
G
G
E
G
W
Q
Q
--
L
R
Q
G
Y
L
P
P
E
F
T-
A
G
L
S
--
S
--
E
L
---------
R
S
V
L
V
M
M
L
E
P
D
P
K
L
R
A
T
A
E
A
L
L
A
L
P
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
97
Blastp_CBE
37.71
32%
-5
- C3 -
-
3P1A
12
PMYT1_HUMAN
A:
[25-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
Q
P
R
R
V
S
F
R
G
E
A
S
E
T
L
Q
S
P
G
Y
D
P
S
R
P
E
S
F
F
--
Q
Q
S
F
Q
R
L
S
R
L
G
H
G
S
Y
G
E
V
F
K
V
R
S
K
E
--
D
--
G
R
L
Y
A
V
K
R
S
M
S
P
-----------
F
R
-----
G
P
K
D
R
-
A
R
K
L
A
E
V
G
-------
S
H
E
K
V
--
G
Q
H
--
P
C
C
V
R
--
L
E
Q
AWEEGG
I
L
----
Y
L
Q
T
E
L
C
-
G
-
P
S
L
Q
Q
--
H
C
E
A
----
W
G
A
-----
S
L
--
P
E
--
A
QVWG
Y
L
R
D
T
L
L
---
A
L
A
H
L
H
S
Q
G
L
V
H
L
D
V
K
P
A
N
I
F
-
L
-
G
P
R
----------------
G
--------
R
C
K
L
G
D
F
G
L
-
L
V
E
L
--
G
--------
V
Q
E
G
D
P
---
R
Y
M
A
P
E
L
L
Q
---------------
G
S
Y
G
---
T
-
A
A
D
V
F
S
L
G
L
T
I
L
E
V
--
A
C
N
M
E
L
P
H
---------
G
G
E
G
W
Q
Q
--
L
R
Q
G
Y
L
P
P
E
F
T-
A
G
L
S
--
S
--
E
L
---------
R
S
V
L
V
M
M
L
E
P
D
P
K
L
R
A
T
A
E
A
L
L
A
L
P
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
161
Blastp_CBE
34.39
31%
-27
- C3 -
-
5CEP
1
M3K12_HUMAN
A:
[20-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
S
G
A
-
Q
G
A
-
V
F
L
G
R
F
--
H
--
G
E
E
V
A
V
K
K
----------------------------
V
R
D
L
K
E
T
D
IKHLRKL
K
H
P
N
I
--
I
T
F
KG
V
C
T
Q
----
A
P
------
C
Y
----
C
I
L
M
E
F
C
---
A
Q
G
Q
L
--
Y
----
E
V
L
R
A
G
RP---
V
T
--
P
S
--
L
----
L
V
D
W
S
M
G
IAG
G
M
N
Y
L
H
L
H
K
I
I
H
R
D
L
K
S
P
N
M
L
-
I
T
Y
D
D
----
V
---------------------
V
K
I
S
D
F
G
-----------------
F
----
A
G
T
V
A
W
M
A
P
E
V
I
R
---------------
N
E
P
V
---
S
E
K
V
D
I
W
S
F
G
V
V
L
W
E
L
--
L
T
-
G
E
I
P
Y
---------
K
D
V
D
S
S
A
--
I
I
W
G
V
G
S
N
S
L
---
H
L
P
--
V
--
P
S
S
C
P
D
G
---
F
K
I
L
L
R
Q
C
W
N
S
K
P
R
N
R
P
S
F
R
Q
I
L
L
H
L
D
I
A
S
ADVL
S
T
P
Q
E
T
Y
F
K
S
Q
A
E
W
R
E
E
--------------------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
34.16
31%
-25
- C3 -
-
5VO2
1
M3K12_HUMAN
A:
[20-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
S
G
A
-
Q
G
A
-
V
F
L
G
R
F
--
H
--
G
E
E
V
A
V
K
K
----------------------------
V
R
D
L
K
E
T
D
IKHLRKL
K
H
P
N
I
--
I
T
F
KG
V
C
T
Q
----
A
P
------
C
Y
----
C
I
L
M
E
F
C
---
A
Q
G
Q
L
--
Y
----
E
V
L
R
A
G
RP---
V
T
--
P
S
--
L
----
L
V
D
W
S
M
G
IAG
G
M
N
Y
L
H
L
H
K
I
I
H
R
D
L
K
S
P
N
M
L
-
I
T
Y
D
D
----
V
---------------------
V
K
I
S
D
F
G
-----------------
F
----
A
G
T
V
A
W
M
A
P
E
V
I
R
---------------
N
E
P
V
---
S
E
K
V
D
I
W
S
F
G
V
V
L
W
E
L
--
L
T
-
G
E
I
P
Y
---------
K
D
V
D
S
S
A
--
I
I
W
G
V
G
S
N
S
L
---
H
L
P
--
V
--
P
S
S
C
P
D
G
---
F
K
I
L
L
R
Q
C
W
N
S
K
P
R
N
R
P
S
F
R
Q
I
L
L
H
L
D
I
A
S
ADVL
S
T
P
Q
E
T
Y
F
K
S
Q
A
E
W
R
E
E
--------------------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
34.02
31%
-20
- C3 -
-
5CEQ
1
M3K12_HUMAN
A:
[20-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
S
G
A
-
Q
G
A
-
V
F
L
G
R
F
--
H
--
G
E
E
V
A
V
K
K
----------------------------
V
R
D
L
K
E
T
D
IKHLRKL
K
H
P
N
I
--
I
T
F
KG
V
C
T
Q
----
A
P
------
C
Y
----
C
I
L
M
E
F
C
---
A
Q
G
Q
L
--
Y
----
E
V
L
R
A
G
RP---
V
T
--
P
S
--
L
----
L
V
D
W
S
M
G
IAG
G
M
N
Y
L
H
L
H
K
I
I
H
R
D
L
K
S
P
N
M
L
-
I
T
Y
D
D
----
V
---------------------
V
K
I
S
D
F
G
-----------------
F
----
A
G
T
V
A
W
M
A
P
E
V
I
R
---------------
N
E
P
V
---
S
E
K
V
D
I
W
S
F
G
V
V
L
W
E
L
--
L
T
-
G
E
I
P
Y
---------
K
D
V
D
S
S
A
--
I
I
W
G
V
G
S
N
S
L
---
H
L
P
--
V
--
P
S
S
C
P
D
G
---
F
K
I
L
L
R
Q
C
W
N
S
K
P
R
N
R
P
S
F
R
Q
I
L
L
H
L
D
I
A
S
ADVL
S
T
P
Q
E
T
Y
F
K
S
Q
A
E
W
R
E
E
--------------------------------------------------------------------------------------------------------------------------------------
159
Blastp_CBE
33.82
31%
-21
- C3 -
-
5VO1
1
M3K12_HUMAN
A:
[20-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
S
G
A
-
Q
G
A
-
V
F
L
G
R
F
--
H
--
G
E
E
V
A
V
K
K
----------------------------
V
R
D
L
K
E
T
D
IKHLRKL
K
H
P
N
I
--
I
T
F
KG
V
C
T
Q
----
A
P
------
C
Y
----
C
I
L
M
E
F
C
---
A
Q
G
Q
L
--
Y
----
E
V
L
R
A
G
RP---
V
T
--
P
S
--
L
----
L
V
D
W
S
M
G
IAG
G
M
N
Y
L
H
L
H
K
I
I
H
R
D
L
K
S
P
N
M
L
-
I
T
Y
D
D
----
V
---------------------
V
K
I
S
D
F
G
-----------------
F
----
A
G
T
V
A
W
M
A
P
E
V
I
R
---------------
N
E
P
V
---
S
E
K
V
D
I
W
S
F
G
V
V
L
W
E
L
--
L
T
-
G
E
I
P
Y
---------
K
D
V
D
S
S
A
--
I
I
W
G
V
G
S
N
S
L
---
H
L
P
--
V
--
P
S
S
C
P
D
G
---
F
K
I
L
L
R
Q
C
W
N
S
K
P
R
N
R
P
S
F
R
Q
I
L
L
H
L
D
I
A
S
ADVL
S
T
P
Q
E
T
Y
F
K
S
Q
A
E
W
R
E
E
--------------------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
32.71
31%
-23
- C3 -
-
5CEO
1
M3K12_HUMAN
A:
[20-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
S
G
A
-
Q
G
A
-
V
F
L
G
R
F
--
H
--
G
E
E
V
A
V
K
K
----------------------------
V
R
D
L
K
E
T
D
IKHLRKL
K
H
P
N
I
--
I
T
F
KG
V
C
T
Q
----
A
P
------
C
Y
----
C
I
L
M
E
F
C
---
A
Q
G
Q
L
--
Y
----
E
V
L
R
A
G
RP---
V
T
--
P
S
--
L
----
L
V
D
W
S
M
G
IAG
G
M
N
Y
L
H
L
H
K
I
I
H
R
D
L
K
S
P
N
M
L
-
I
T
Y
D
D
----
V
---------------------
V
K
I
S
D
F
G
-----------------
F
----
A
G
T
V
A
W
M
A
P
E
V
I
R
---------------
N
E
P
V
---
S
E
K
V
D
I
W
S
F
G
V
V
L
W
E
L
--
L
T
-
G
E
I
P
Y
---------
K
D
V
D
S
S
A
--
I
I
W
G
V
G
S
N
S
L
---
H
L
P
--
V
--
P
S
S
C
P
D
G
---
F
K
I
L
L
R
Q
C
W
N
S
K
P
R
N
R
P
S
F
R
Q
I
L
L
H
L
D
I
A
S
ADVL
S
T
P
Q
E
T
Y
F
K
S
Q
A
E
W
R
E
E
--------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
31.56
34%
-2
- C3 -
-
4B6L
1
PLK3_HUMAN
A:
[34-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
A
Y
A
V
K
V
I
P
Q
S
-----------
R
V
-----
A
K
P
H
Q
R
E
K
I
L
N
E
I
E
LHRDL--
Q
H
R
H
I
--
V
R
F
--
S
H
H
F
E
--
D
A
D
------
N
I
----
Y
I
F
L
E
L
C
S
R
-
K
S
L
A
H
--
I
W
K
A
---
R
H
T
L
-----
L
E
--
P
E
--
V
RY--
Y
L
R
Q
I
L
S
---
G
L
K
Y
L
H
Q
R
G
I
L
H
R
D
L
K
L
G
N
F
F
-
I
T
E
N
M
----
E
--------
L
K
V
G
-------------
D
F
G
L
-
A
A
R
L
EP
P
E
Q
R
------
K
K
T
I
C
G
T
P
N
Y
V
A
P
E
V
L
-----
L
R
---
Q
----
G
H
G
P
E
---
A
---
D
V
W
S
L
G
C
V
M
Y
T
L
--
L
C
-
G
S
P
P
F
--------------
E
T
--
A
D
L
K
E
T
Y
R
C
I
KQ
V
H
Y
T
--
L
--
P
A
S
L
S
L
P
---
A
R
Q
L
L
A
A
I
L
R
A
S
P
R
D
R
P
S
I
D
Q
I
L
R
H
D
F
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
29.93
31%
4
- C3 -
-
4EUU
4
TBK1_HUMAN
A:
[15-247]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
L
G
Q
G
A
-
T
A
N
-
V
F
R
G
R
H
--
K
KT
G
D
L
F
A
I
K
V
F
N
N
I
-----------
S
F
LRPV-
D
V
Q
M
R
E
F
E
V
L
K
K
L
N
--------
H
K
N
I
--
V
K
L
--
F
A
I
E
E
ET
T
T
R
------
H
K
----
V
L
I
M
E
F
C
P
C
-
G
S
L
Y
T
--
V
L
E
E
P
S
N
A
Y
G
L
-----
P
E
--
S
E
FL
I
----
V
L
R
D
V
V
G
---
G
M
N
H
L
R
E
N
G
I
V
H
R
N
I
K
P
G
N
I
M
R
V
I
G
E
D
----
G
--------
Q
S
V
Y
--------
K
--
L
T
D
F
G
A
-
A
R
E
L
--
E
D
D
E
-
Q
F
-
V
L
Y
----
G
T
E
E
Y
L
H
P
D
M
Y
E
RA--
V
L
---
R
----
K
D
H
Q
K
KYG
A
-
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
--
A
T
-
G
S
L
P
F
RPFEGPRRN
K
E
V
M
Y
K
-----
I
I
T
G
K
P
S
G
--
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Blastp_CBE
29.21
31%
5
- C3 -
-
4EUU
6
TBK1_HUMAN
B:
[15-247]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
L
G
Q
G
A
-
T
A
N
-
V
F
R
G
R
H
--
K
KT
G
D
L
F
A
I
K
V
F
N
N
I
-----------
S
F
LRPV-
D
V
Q
M
R
E
F
E
V
L
K
K
L
N
--------
H
K
N
I
--
V
K
L
--
F
A
I
E
E
ET
T
T
R
------
H
K
----
V
L
I
M
E
F
C
P
C
-
G
S
L
Y
T
--
V
L
E
E
P
S
N
A
Y
G
L
-----
P
E
--
S
E
FL
I
----
V
L
R
D
V
V
G
---
G
M
N
H
L
R
E
N
G
I
V
H
R
N
I
K
P
G
N
I
M
R
V
I
G
E
D
----
G
--------
Q
S
V
Y
--------
K
--
L
T
D
F
G
A
-
A
R
E
L
--
E
D
D
E
-
Q
F
-
V
L
Y
----
G
T
E
E
Y
L
H
P
D
M
Y
E
RA--
V
L
---
R
----
K
D
H
Q
K
KYG
A
-
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
--
A
T
-
G
S
L
P
F
RPFEGPRRN
K
E
V
M
Y
K
-----
I
I
T
G
K
P
S
G
--
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
27.75
31%
-7
- C3 -
-
6HXF
5
STK10_HUMAN
B:
[66-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
E
I
L
A
T
C
D
--------
H
P
Y
I
--
V
K
L
--
L
------
G
A
Y
------
Y
H
DGKL
W
I
M
I
E
F
C
-
P
-
G
G
A
V
D
--
A
I
M
-
L
E
L
D
R
G
L
-----
T
E
--
P
Q
IQ
V
----
V
C
R
Q
M
L
E
---
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
-
M
T
L
E
-----------------
G
--------
D
I
R
L
A
D
F
G
V
S
A
K
N
L
--
K
L
Q
K
R
D
F
-
I
------
G
T
P
Y
W
M
A
P
E
V
V
M
----
C
E
---
M
----
K
D
T
P
Y
---
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
AQ
I
E
P
P
H
H
E
L
---------
N
P
M
R
V
L
L
--
K
I
A
K
S
D
P
P
T
L
--
L
T
P
S
--
K
--
W
---
S
V
E
---
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
27.36
31%
-1
- C3 -
-
6BOD
1
TBK1_HUMAN
A:
[16-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
L
G
Q
G
A
-
T
A
N
-
V
F
R
G
R
H
--
K
KT
G
D
L
F
A
I
K
V
F
N
---------------------
V
Q
M
R
E
F
E
V
L
K
K
L
N
--------
H
K
N
I
--
V
K
L
--
F
A
I
E
E
ET
T
T
R
------
H
K
----
V
L
I
M
E
F
C
P
C
-
G
S
L
Y
T
--
V
L
E
E
P
S
N
A
Y
G
L
-----
P
E
--
S
E
FL
I
----
V
L
R
D
V
V
G
---
G
M
N
H
L
R
E
N
G
I
V
H
R
D
I
K
P
G
N
I
M
R
V
I
G
E
D
----
G
--------
Q
S
V
Y
--------
K
--
L
T
D
F
G
A
-
A
R
E
-------------------
T
E
E
Y
L
H
P
D
M
Y
E
R---------------------
A
-
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
---
A
T
G
S
L
P
F
RPFEGPRRN
K
E
V
M
Y
K
-----
I
I
T
G
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
27.23
32%
-24
- C3 -
-
6HK4
9
GSK3B_HUMAN
A:
[19-227]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
-
F
G
V
-
V
Y
Q
A
K
L
CD
S
--
G
E
L
V
A
I
K
K
V
L
Q
D
-----------
K
------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
--------
H
C
N
I
VR
L
R
Y
--
F
F
Y
S
S
--
G
E
K
------
K
D
----
E
V
Y
L
N
L
V
-
L
-
D
Y
V
P
E
TV
Y
R
V
A
R
H
Y
S
R
A
K
QTLPV
I
Y
--
V
K
--
L
----
Y
M
Y
Q
L
F
R
---
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
-
L
-
D
P
D
----
T
--------
A
V
L
K
-----------
L
C
D
F
G
S
-
A
K
Q
L
--
V
R
G
E
P
N
V
-
S
I
C
S
-----
R
Y
Y
R
A
P
E
L
------
I
F
---
G
----
A
T
D
Y
T
---
S
-
S
I
D
V
W
S
A
G
C
V
L
A
E
L
--
L
L
G
Q
P
I
F
P
---------
G
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
26.98
32%
25
- C3 -
-
5VCZ
7
PMYT1_HUMAN
A:
[16-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
H
Q
L
Q
P
R
R
V
S
F
R
G
E
A
S
E
T
L
Q
S
P
G
Y
D
P
S
R
P
E
S
F
F
--
Q
Q
S
F
Q
R
L
S
R
L
G
H
G
S
Y
G
E
V
F
K
V
R
S
K
E
--
D
--
G
R
L
Y
A
V
K
R
S
M
S
P
-----------
F
R
-----
G
P
K
D
R
-
A
R
K
L
A
E
V
G
-------
S
H
E
K
V
--
G
Q
H
--
P
C
C
V
R
--
L
E
Q
AWEEGG
I
L
----
Y
L
Q
T
E
L
C
-
G
-
P
S
L
Q
Q
--
H
C
E
A
----
W
G
A
-----
S
L
--
P
E
--
A
QVWG
Y
L
R
D
T
L
L
---
A
L
A
H
L
H
S
Q
G
L
V
H
L
D
V
K
P
A
N
I
F
-
L
-
G
P
R
----------------
G
--------
R
C
K
L
G
D
F
G
L
-
L
V
E
L
--
G
T
A
G
A
G
--
E
V
Q
E
G
D
P
---
R
Y
M
A
P
E
L
L
Q
---------------
G
S
Y
G
---
T
-
A
A
D
V
F
S
L
G
L
T
I
L
E
V
--
A
C
N
M
E
L
P
H
---------
G
G
E
G
W
Q
Q
--
L
R
Q
G
Y
L
P
P
E
F
T-
A
G
L
S
--
S
--
E
L
---------
R
S
V
L
V
M
M
L
E
P
D
P
K
L
R
A
T
A
E
A
L
L
A
L
P
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
26.37
32%
-34
- C3 -
-
3F88
1
GSK3B_HUMAN
B:
[19-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
-
F
G
V
-
V
Y
Q
A
K
L
CD
S
--
G
E
L
V
A
I
K
K
V
L
Q
D
-----------
K
------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
--------
H
C
N
I
VR
L
R
Y
--
F
F
Y
S
S
------------------
V
Y
L
N
L
V
-
L
-
D
Y
V
P
E
TV
Y
R
V
A
R
H
Y
S
R
A
K
QTLPV
I
Y
--
V
K
--
L
----
Y
M
Y
Q
L
F
R
---
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
-
L
-
D
P
D
----
T
--------
A
V
L
K
-----------
L
C
D
F
G
S
-
A
K
Q
L
--
V
R
G
E
P
N
V
-
S
I
C
S
-----
R
Y
Y
R
A
P
E
L
------
I
F
---
G
----
A
T
D
Y
T
---
S
-
S
I
D
V
W
S
A
G
C
V
L
A
E
L
--
L
L
G
Q
P
I
F
P
---------
G
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
Blastp_CBE
26.34
32%
-15
- C3 -
-
6HK7
3
GSK3B_HUMAN
A:
[18-226]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
-
F
G
V
-
V
Y
Q
A
K
L
CD
S
--
G
E
L
V
A
I
K
K
V
L
Q
D
-----------
K
------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
--------
H
C
N
I
VR
L
R
Y
--
F
F
Y
S
S
--
G
E
K
------
K
D
----
E
V
Y
L
N
L
V
-
L
-
D
Y
V
P
E
TV
Y
R
V
A
R
H
Y
S
R
A
K
QTLPV
I
Y
--
V
K
--
L
----
Y
M
Y
Q
L
F
R
---
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
-
L
-
D
P
D
----
T
--------
A
V
L
K
-----------
L
C
D
F
G
S
-
A
K
Q
L
--
V
R
G
E
P
N
V
-
S
I
C
S
-----
R
Y
Y
R
A
P
E
L
------
I
F
---
G
----
A
T
D
Y
T
---
S
-
S
I
D
V
W
S
A
G
C
V
L
A
E
L
--
L
L
G
Q
P
I
F
P
---------
G
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
26.05
32%
-33
- C3 -
-
3F88
1
GSK3B_HUMAN
A:
[19-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
-
F
G
V
-
V
Y
Q
A
K
L
CD
S
--
G
E
L
V
A
I
K
K
V
L
Q
D
-----------
K
------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
--------
H
C
N
I
VR
L
R
Y
--
F
F
Y
S
S
------------------
V
Y
L
N
L
V
-
L
-
D
Y
V
P
E
TV
Y
R
V
A
R
H
Y
S
R
A
K
QTLPV
I
Y
--
V
K
--
L
----
Y
M
Y
Q
L
F
R
---
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
-
L
-
D
P
D
----
T
--------
A
V
L
K
-----------
L
C
D
F
G
S
-
A
K
Q
L
--
V
R
G
E
P
N
V
-
S
I
C
S
-----
R
Y
Y
R
A
P
E
L
------
I
F
---
G
----
A
T
D
Y
T
---
S
-
S
I
D
V
W
S
A
G
C
V
L
A
E
L
--
L
L
G
Q
P
I
F
P
---------
G
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
25.93
32%
25
- C3 -
-
5VCY
6
PMYT1_HUMAN
A:
[16-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
H
Q
L
Q
P
R
R
V
S
F
R
G
E
A
S
E
T
L
Q
S
P
G
Y
D
P
S
R
P
E
S
F
F
--
Q
Q
S
F
Q
R
L
S
R
L
G
H
G
S
Y
G
E
V
F
K
V
R
S
K
E
--
D
--
G
R
L
Y
A
V
K
R
S
M
S
P
-----------
F
R
-----
G
P
K
D
R
-
A
R
K
L
A
E
V
G
-------
S
H
E
K
V
--
G
Q
H
--
P
C
C
V
R
--
L
E
Q
AWEEGG
I
L
----
Y
L
Q
T
E
L
C
-
G
-
P
S
L
Q
Q
--
H
C
E
A
----
W
G
A
-----
S
L
--
P
E
--
A
QVWG
Y
L
R
D
T
L
L
---
A
L
A
H
L
H
S
Q
G
L
V
H
L
D
V
K
P
A
N
I
F
-
L
-
G
P
R
----------------
G
--------
R
C
K
L
G
D
F
G
L
-
L
V
E
L
--
G
T
A
G
A
G
--
E
V
Q
E
G
D
P
---
R
Y
M
A
P
E
L
L
Q
---------------
G
S
Y
G
---
T
-
A
A
D
V
F
S
L
G
L
T
I
L
E
V
--
A
C
N
M
E
L
P
H
---------
G
G
E
G
W
Q
Q
--
L
R
Q
G
Y
L
P
P
E
F
T-
A
G
L
S
--
S
--
E
L
---------
R
S
V
L
V
M
M
L
E
P
D
P
K
L
R
A
T
A
E
A
L
L
A
L
P
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
25.91
32%
-18
- C3 -
-
6HK3
5
GSK3B_HUMAN
A:
[19-227]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
-
F
G
V
-
V
Y
Q
A
K
L
CD
S
--
G
E
L
V
A
I
K
K
V
L
Q
D
-----------
K
------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
--------
H
C
N
I
VR
L
R
Y
--
F
F
Y
S
S
--
G
E
K
------
K
D
----
E
V
Y
L
N
L
V
-
L
-
D
Y
V
P
E
TV
Y
R
V
A
R
H
Y
S
R
A
K
QTLPV
I
Y
--
V
K
--
L
----
Y
M
Y
Q
L
F
R
---
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
-
L
-
D
P
D
----
T
--------
A
V
L
K
-----------
L
C
D
F
G
S
-
A
K
Q
L
--
V
R
G
E
P
N
V
-
S
I
C
S
-----
R
Y
Y
R
A
P
E
L
------
I
F
---
G
----
A
T
D
Y
T
---
S
-
S
I
D
V
W
S
A
G
C
V
L
A
E
L
--
L
L
G
Q
P
I
F
P
---------
G
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
25.25
32%
-15
- C3 -
-
6HK4
10
GSK3B_HUMAN
B:
[19-227]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
-
F
G
V
-
V
Y
Q
A
K
L
CD
S
--
G
E
L
V
A
I
K
K
V
L
Q
D
-----------
K
------
R
F
K
N
R
E
L
Q
I
M
R
K
L
D
--------
H
C
N
I
VR
L
R
Y
--
F
F
Y
S
S
--
G
E
K
------
K
D
----
E
V
Y
L
N
L
V
-
L
-
D
Y
V
P
E
TV
Y
R
V
A
R
H
Y
S
R
A
K
QTLPV
I
Y
--
V
K
--
L
----
Y
M
Y
Q
L
F
R
---
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
-
L
-
D
P
D
----
T
--------
A
V
L
K
-----------
L
C
D
F
G
S
-
A
K
Q
L
--
V
R
G
E
P
N
V
-
S
I
C
S
-----
R
Y
Y
R
A
P
E
L
------
I
F
---
G
----
A
T
D
Y
T
---
S
-
S
I
D
V
W
S
A
G
C
V
L
A
E
L
--
L
L
G
Q
P
I
F
P
---------
G
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
24.74
31%
-8
- C3 -
-
6HXF
4
STK10_HUMAN
D:
[66-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
E
I
L
A
T
C
D
--------
H
P
Y
I
--
V
K
L
--
L
------
G
A
Y
------
Y
H
DGKL
W
I
M
I
E
F
C
-
P
-
G
G
A
V
D
--
A
I
M
-
L
E
L
D
R
G
L
-----
T
E
--
P
Q
IQ
V
----
V
C
R
Q
M
L
E
---
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
-
M
T
L
E
-----------------
G
--------
D
I
R
L
A
D
F
G
V
S
A
K
N
L
--
K
L
Q
K
R
D
F
-
I
------
G
T
P
Y
W
M
A
P
E
V
V
M
----
C
E
---
M
----
K
--
P
Y
---
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
AQ
I
E
P
P
H
H
E
L
---------
N
P
M
R
V
L
L
--
K
I
A
K
S
D
P
P
T
L
--
L
T
P
S
--
K
--
W
---
S
V
E
---
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------