@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : FER_HUMAN: (2020-09-09 )
MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKESTVQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQIEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNLTAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRKLT
Atome Classification :
(486 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470..----.----.----...----480.......490.....-----..-----500---..------.......510-.--...-.-.-.-.520.......530....-...-------540.....-----..-----550---.------------.--------------------------..-----..-------------------..-------.560.-.-.....570.......580----.----.-------..-.------..590......-.600..-...-..610...-....620.......630........640.......650..------.-.-----------------..-..660.......670.......680.......690---....-----...700.....---.-.710..--.-..-..-720.......730.......740.......750.......760..-.-....770.......780.......790.......800.......810.......820
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGF
G
S
DLK
N
S
H
E
A
V
L
K
LQ
D
W
E
L
R
L
L
E
T
V
K
K
F
M
A
L
RIKS
D
K
E
Y
A
S
T
L
Q
N
L
C
N
QVDKES
T
V
Q
M
N
Y
V
S
NV
S
K
S
W
L
L
M
IQ
Q
T
E
Q
L
S
R
I
M
K
T
H
A
E
DLNSG
P
L
H
R
L
T
M
M
IK
D
K
Q
Q
V
K
K
S
Y
I
G
V
H
Q
Q
I
E
A
E
M
I
K
V
T
K
T
E
L
E
K
L
K
C
S
Y
R
Q
L
I
K
E
M
N
S
A
K
E
K
Y
K
E
A
L
AKGK
E
T
E
K
A
K
E
R
Y
D
K
A
T
M
K
L
H
M
L
HN
Q
Y
V
L
A
LKGAQLHQN
Q
Y
Y
D
I
T
L
P
L
L
L
D
S
L
Q
K
M
Q
E
E
M
I
K
A
L
K
G
I
F
D
E
Y
S
Q
I
T
S
L
V
T
E
E
I
V
N
V
H
K
E
I
Q
M
S
V
E
QIDPSTEYN
N
F
I
D
V
HRTTAAKEQEIEF
D
T
S
L
L
EENENLQAN
E
I
MWNNL
T
A
E
S
L
Q
V
M
L
K
T
L
A
E
E
L
M
Q
T
Q
Q
M
L
LN
K
E
E
A
V
L
E
L
E
K
R
I
E
E
S
S
E
T
C
EKKS
D
I
V
L
L
L
S
Q
K
Q
A
L
E
E
L
K
Q
S
V
Q
Q
L
RC
T
E
A
K
F
S
A
Q
K
E
L
L
E
Q
K
V
Q
ENDGKEPPPVV
N
Y
E
E
D
A
R
S
V
T
S
M
E
R
K
E
R
L
S
K
F
E
S
I
R
H
S
I
A
G
I
IR
S
P
K
S
AL
G
S
S
A
L
S
D
M
I
S
ISEKPLAEQDWYHGAIP
R
I
E
A
Q
E
L
L
----
K
----K----QG
D
----
F
L
V
RESHGKPG
E
Y
V
L
S
VY-----SD-----G-----Q
R
------
R
H
F
I
I
Q
YV-D-
N
--
M
Y
R
-F-E-G-TGF
S
N
I
P
Q
L
I
D
HHY
T
T
K
Q
-
V
I
T-------KKS
G
V
V
L
L-----NP-----I-----P------------K--------------------------DK-----
K
W
-------------------
I
L-------SHE
D
V
-
I
-
L
G
E
L
LGKGNF
G
E
V
Y
K
GTL----K----D-------K
T
-
S
------
V
A
V
K
T
C
K
E
DL
P
-
Q
E
L
K
I
K
-
F
L
Q
-
E
A
K
I
L
K
QY-DH
P
N
I
V
K
L
I
G
V
CTQR-Q
P
V
Y
I
I
M
E
L
VSGG
D
F
L
T
F
L
R
R-
K
K
------
D
-
E
-----------------
L
K
-
L
K
Q
L
V
K
F
S
LDAAA
G
M
L
Y
LESKN
C
I
H
R
D
L
A
ARNCLV---GEN
N
-----
V
L
K
I
SDFGMSR---Q-EDGGVY--S-SS-G
L
-
K
QI
P
I
K
WTAPEALNYGRYSSES
D
V
W
S
F
G
I
L
L
W
E
TFSLGVCPYPGM-T-
N
Q
Q
A
R
E
Q
V
E
RGYRMSAPQH
C
P
E
D
I
S
K
I
M
M
K
CWDYKPENRP
K
F
S
E
L
Q
K
E
L
T
I
I
K
RKLT
532
HHSearch
89.89
67%
-35
- C2 -
-
6JMF
1
A:
[4-374]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
----
V
----
H
----
S
G
D
----
F
L
V
R
E
S
Q
G
K
-
Q
E
Y
V
L
S
V
L
-----
W
D
-----
G
-----
L
P
------
R
H
F
I
I
Q
S
L
-
D
-
N
--
L
Y
R
-
L
-
E
-
G
-
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
-
P
L
T
-------
K
K
S
G
V
V
L
H
-----
R
A
-----
V
-----
P
------------
K
---------------------------
D
-----
K
W
-------------------
V
L
-------
N
H
E
D
L
-
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
----
R
A---
D
-------
N
T
-
L
------
V
A
V
K
S
C
R
E
T
L
P
-
P
D
L
K
A
K
-
F
L
Q
-
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
G
------
A
-
R
-----------------
L
R
-
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
---
T
E
K
N
-----
V
L
K
I
S
D
F
G
M
S
R
---
E
-
E
A
D
G
V
Y
--
A
A
S
G
-
G
L
-
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
-
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
-
531
HHSearch
89.22
66%
-32
- C2 -
-
3BKB
9
A:
[5-376]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
----
V
----
H
----
S
G
D
----
F
L
V
R
E
S
Q
G
-
K
Q
E
Y
V
L
S
V
L
-----
W
D
-----
G
-----
L
P
------
R
H
F
I
I
Q
S
L
-
D
-
N
--
L
Y
R
-
L
-
E
-
G
-
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
-
P
L
T
-------
K
K
S
G
V
V
L
H
-----
R
A
-----
V
-----
P
------------
K
---------------------------
D
-----
K
W
-------------------
V
L
-------
N
H
E
D
L
-
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
----
R
A---
D
-------
N
T
-
L
------
V
A
V
K
S
C
R
E
T
L
P
-
P
D
L
K
A
K
-
F
L
Q
-
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
G
------
A
-
R
-----------------
L
R
-
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
---
T
E
K
N
-----
V
L
K
I
S
D
F
G
M
S
R
---
E
-
E
A
D
G
V
Y
--
A
A
S
G
-
G
L
-
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
-
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
-
1
PsiBlast_PDB
89.18
66%
-32
- C2 -
-
3BKB
9
A:
[4-375]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
----
V
----
H
----
S
G
D
----
F
L
V
R
E
S
Q
G
K
-
Q
E
Y
V
L
S
V
L
-----
W
D
-----
G
-----
L
P
------
R
H
F
I
I
Q
S
L
-
D
-
N
--
L
Y
R
-
L
-
E
-
G
-
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
-
P
L
T
-------
K
K
S
G
V
V
L
H
-----
R
A
-----
V
-----
P
------------
K
--------------------------
D
K
------
W
-------------------
V
L
-------
N
H
E
D
L
-
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
----
R
A---
D
-------
N
T
-
L
------
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A
V
K
S
C
R
E
T
L
P
-
P
D
L
K
A
K
-
F
L
Q
-
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
G
------
A
-
R
-----------------
L
R
-
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
---
T
E
K
N
-----
V
L
K
I
S
D
F
G
M
S
R
---
E
-
E
A
D
G
V
Y
--
A
-
A
S
G
G
L
-
R
Q
V
P
V
K
W
T
A
P
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A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
-
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
--
4
PsiBlast_PDB
89.04
66%
-35
- C2 -
-
6JMF
1
A:
[5-373]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
----
V
----
H
----
S
G
D
----
F
L
V
R
E
S
Q
G
K
Q
-
E
Y
V
L
S
V
L
-----
W
D
-----
G
-----
L
P
------
R
H
F
I
I
Q
S
L
-
D
-
N
--
L
Y
R
-
L
-
E
-
G
-
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
-
P
L
T
-------
K
K
S
G
V
V
L
H
-----
R
A
-----
V
-----
P
------------
K
--------------------------
D
K
------
W
-------------------
V
L
-------
N
H
E
D
L
-
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
----
R
A---
D
-------
N
T
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L
------
V
A
V
K
S
C
R
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P
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P
D
L
K
A
K
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F
L
Q
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A
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I
L
K
Q
Y
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S
H
P
N
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V
R
L
I
G
V
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T
Q
K
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Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
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E
G
------
A
-
R
-----------------
L
R
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K
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L
L
Q
M
V
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D
A
A
A
G
M
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L
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C
I
H
R
D
L
A
A
R
N
C
L
V
---
T
E
K
N
-----
V
L
K
I
S
D
F
G
M
S
R
---
E
-
E
A
D
G
V
Y
--
A
-
A
S
G
G
L
-
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
-
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
--
3
PsiBlast_PDB
87.41
66%
-50
- C2 -
-
4E93
1
A:
[2-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
----
V
----
H
----
S
G
D
----
F
L
V
R
E
S
Q
---
Q
E
Y
V
L
S
V
L
-----
W
D
-----
G
-----
L
P
------
R
H
F
I
I
Q
S
L
-
D
-
N
--
L
Y
R
-
L
-
E
-
G
-
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
-
P
L
T
-------
K
K
S
G
V
V
L
H
-----
R
A
-----
V
-----
P
------------
K
--------------------------
D
K
------
W
-------------------
V
L
-------
N
H
E
D
L
-
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
----
R
A---
D
-------
N
T
-
L
------
V
A
V
K
S
C
R
E
T
L
P
-
P
D
L
K
A
K
-
F
L
Q
-
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
G
------
A
-
R
-----------------
L
R
-
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
---
T
E
K
N
-----
V
L
K
I
S
D
F
G
M
S
R
---
E
-------------------
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
-
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
--
2
PsiBlast_PDB
86.02
66%
-40
- C2 -
-
3CBL
3
A:
[2-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
----
V
----
H
----
S
G
D
----
F
L
V
R
E
S
Q
---
Q
E
Y
V
L
S
V
--------------------
P
------
R
H
F
I
I
------
N
--
L
Y
R
-
L
-------
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
-
P
L
------------
V
V
L
H
-----
R
A
-----
V
-----
P
------------
K
--------------------------
D
K
------
W
-------------------
V
L
-------
N
H
E
D
L
-
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
----
R
A---
D
-------
N
T
-
L
------
V
A
V
K
S
C
R
E
T
L
P
-
P
D
L
K
A
K
-
F
L
Q
-
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
G
------
A
-
R
-----------------
L
R
-
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
---
T
E
K
N
-----
V
L
K
I
S
D
F
G
M
S
R
---
E
-
E
A
D
G
V
Y
--
A
-
A
S
G
G
L
-
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
-
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
--
533
HHSearch
85.50
66%
-40
- C2 -
-
3CBL
3
A:
[4-376]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
----
V
----
H
----
S
G
D
----
F
L
V
R
E
S
Q
---
Q
E
Y
V
L
S
V
--------------------
P
------
R
H
F
I
I
------
N
--
L
Y
R
-
L
-------
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
-
P
L
------------
V
V
L
H
-----
R
A
-----
V
-----
P
------------
K
---------------------------
D
-----
K
W
-------------------
V
L
-------
N
H
E
D
L
-
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
----
R
A---
D
-------
N
T
-
L
------
V
A
V
K
S
C
R
E
T
L
P
-
P
D
L
K
A
K
-
F
L
Q
-
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
G
------
A
-
R
-----------------
L
R
-
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
---
T
E
K
N
-----
V
L
K
I
S
D
F
G
M
S
R
---
E
-
E
A
D
G
V
Y
--
A
A
S
G
-
G
L
-
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
-
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
-
5
PsiBlast_PDB
84.85
65%
-40
- C2 -
-
3CD3
3
A:
[2-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
----
V
----
H
----
S
G
D
----
F
L
V
R
E
S
----
Q
E
Y
V
L
S
V
--------------------
P
------
R
H
F
I
I
------
N
--
L
Y
R
-
L
-------
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
-
P
L
----------
S
G
V
V
L
H
-----
R
A
-----
V
-----
P
------------
K
--------------------------
D
K
------
W
-------------------
V
L
-------
N
H
E
D
L
-
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
----
R
A---
D
-------
N
T
-
L
------
V
A
V
K
S
C
R
-----
P
D
L
K
A
K
-
F
L
Q
-
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
G
------
A
-
R
-----------------
L
R
-
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
---
T
E
K
N
-----
V
L
K
I
S
D
F
G
M
S
R
---
E
-
E
A
D
G
V
Y
--
A
-
A
S
G
G
L
-
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
-
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
--
550
Fugue
78.59
66%
-39
- C2 -
-
3CD3
3
A:
[1-376]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
I
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
----
V
----
H
----
S
G
D
----
F
L
V
R
E
S
Q
----
E
Y
V
L
S
V
--------------------
P
------
R
H
F
I
I
------
N
--
L
Y
R
-
L
-------
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
-
P
L
----------
S
G
V
V
L
H
-----
R
A
-----
V
-----
P
------------
K
--------------------------
D
K
------
W
-------------------
V
L
-------
N
H
E
D
L
-
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
----
R
A---
D
-------
N
T
-
L
------
V
A
V
K
S
C
R
P
-----
D
L
K
A
K
-
F
L
Q
-
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
G
------
A
-
R
-----------------
L
R
-
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
---
T
E
K
N
-----
V
L
K
I
S
D
F
G
M
S
R
---
E
-
E
A
D
G
V
A
--
A
-
S
G
-
G
L
-
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
-
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
-
8
PsiBlast_PDB
73.25
40%
19
- C2 -
-
1OPK
3
ABL1_MOUSE
A:
[102-473]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
----
S
----
S
GI--
N
G
S
----
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
-----
G
-----
R
V
------
Y
H
Y
R
I
N
T
A
-
S
-
D
GK
L
Y
V
-
S
-
S
-
E
-
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
TLHYPAP
K
R
N
K
P
T
I
Y
-----
G
V
-----
S
-----
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
549
HHSearch
72.72
41%
18
- C2 -
-
1OPK
3
ABL1_MOUSE
A:
[100-479]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
----
S
----
S
GI--
N
G
S
----
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
-----
G
-----
R
V
------
Y
H
Y
R
I
N
T
A
S
D
-
G
--
K
L
Y
V
S
-
S
-
E
-
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
-
G
L
I
-----------
T
T
L
H
-----
Y
P
-----
A
-----
P
KRNKPTIYGVSP
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
Y------
S
L
-
T
------
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R-----
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--
10
PsiBlast_PDB
72.67
40%
22
- C2 -
-
1OPL
2
ABL1_HUMAN
A:
[141-512]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
----
S
----
S
GI--
N
G
S
----
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
-----
G
-----
R
V
------
Y
H
Y
R
I
N
T
A
-
S
-
D
GK
L
Y
V
-
S
-
S
-
E
-
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
TLHYPAP
K
R
N
K
P
T
V
Y
-----
G
V
-----
S
-----
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
9
PsiBlast_PDB
72.61
40%
22
- C2 -
-
2FO0
4
ABL1_HUMAN
A:
[99-470]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
----
S
----
S
GI--
N
G
S
----
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
-----
G
-----
R
V
------
Y
H
Y
R
I
N
T
A
-
S
-
D
GK
L
Y
V
-
S
-
S
-
E
-
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
TLHYPAP
K
R
N
K
P
T
V
Y
-----
G
V
-----
S
-----
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
539
HHSearch
72.11
40%
28
- C2 -
-
1Y57
1
SRC_HUMAN
A:
[60-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
----
L
----
N
AENP
R
G
T
----
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
-----
D
F
-----
D
NAKGL
N
V
------
K
H
Y
K
I
R
K
L
-
D
S
G
--
G
F
Y
I
T
-
S
-
R
-
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
-
G
L
C
-------
H
R
L
T
T
V
C
P
-----
T
S
KPQTQ
G
-----
L
------------
A
--------------------------
K
D
-----
A
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
P
G
T
M
---
S
P
E
A
-
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
T
G-----
K
-
Y
-----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
D
N
E
Y
--
T
-
A
R
-
Q
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
--
548
HHSearch
71.51
41%
15
- C2 -
-
2FO0
4
ABL1_HUMAN
A:
[97-476]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
----
S
----
S
GI--
N
G
S
----
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
-----
G
-----
R
V
------
Y
H
Y
R
I
N
T
A
S
D
-
G
--
K
L
Y
V
S
-
S
-
E
-
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
-
G
L
I
-----------
T
T
L
H
-----
Y
P
-----
A
-----
P
KRNKPTVYGVSP
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
Y------
S
L
-
T
------
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R-----
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--
541
HHSearch
71.27
40%
25
- C2 -
-
2H8H
1
SRC_HUMAN
A:
[143-524]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
----
L
----
N
AENP
R
G
T
----
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
-----
D
F
DNAKG
L
-----
N
V
------
K
H
Y
K
I
R
K
L
-
D
S
G
--
G
F
Y
I
T
-
S
-
R
-
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
-
G
L
C
-------
H
R
L
T
T
V
C
P
-----
T
S
KPQTQ
G
-----
L
------------
A
--------------------------
K
D
-----
A
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
P
G
T
---
M
S
P
E
A
-
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
T
G-----
K
-
Y
-----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
D
N
E
Y
--
T
-
A
R
-
Q
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
--
542
HHSearch
70.61
40%
24
- C2 -
-
1FMK
-
SRC_HUMAN
A:
[141-522]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
----
L
----
N
AENP
R
G
T
----
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
-----
D
F
-----
D
NAKGL
N
V
------
K
H
Y
K
I
R
K
L
-
D
S
G
--
G
F
Y
-
I
-
T
S
R
-
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
-
G
L
C
-------
H
R
L
T
T
V
C
P
-----
T
S
-----
K
PQTQG
L
------------
A
--------------------------
K
D
-----
A
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
P
G
T
M
---
S
P
E
A
-
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
T
G-----
K
-
Y
-----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
--
22
Blastp_CBE
70.56
40%
17
- C2 -
-
1OPL
1
ABL1_HUMAN
B:
[141-512]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
----
S
----
S
GI--
N
G
S
----
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
-----
G
-----
R
V
------
Y
H
Y
R
I
N
T
A
-
S
-
D
GK
L
Y
V
-
S
-
S
-
E
-
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
TLHYPAP-------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
391
Blastp_CBE
70.27
40%
-132
- C2 -
-
4HCU
1
A:
[5-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
V
I
-------
D
P
S
E
L
-
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
----
L
----
N
-------
K
D
-
K
------
V
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---
F
I
E
-
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
R
------
G
-
L
-----------------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
R
---
F
-
V
L
D
D
Q
Y
--
T
-
S
S
-
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
-----
543
HHSearch
69.76
38%
34
- C2 -
-
5H0B
1
HCK_HUMAN
A:
[65-445]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
PGNM
L
G
S
----
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
DYDPR
Q
G
-----
D
-----
T
V
------
K
H
Y
K
I
R
T
L
D
N
-
G
--
G
F
Y
I
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
QKPW--------
E
--------------------------
K
D
-----
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
P
G
S
---
M
S
V
E
A
-
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
--
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
G-----
S
-
K
-----------------
Q
P
-
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
E
D
N
E
Y
--
T
-
A
R
-
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
--
163
Blastp_CBE
69.25
40%
51
- C2 -
-
2H8H
1
SRC_HUMAN
A:
[136-518]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
-
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
LNAE
N
----
P
----
R
G
T
----
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
------
S
D
-----
F
-----
D
N
AKGLNV
K
H
Y
K
I
R
K
L
-
D
-
S
GG
F
Y
I
-
T
-
S
-
R
-
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
-
G
L
C
-------
H
R
L
T
T
V
C
P
-----
T
S
-----
K
-----
P
------------
Q
--------------------------
T
Q
GLAKD
A
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
T
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
D
N
E
Y
--
T
-
A
R
-
Q
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
393
Blastp_CBE
69.24
40%
-129
- C2 -
-
3T9T
3
A:
[3-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
V
I
-------
D
P
S
E
L
-
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
----
L
----
N
-------
K
D
-
K
------
V
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---
F
I
E
-
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
T
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
R
------
G
-
L
-----------------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
R
---
F
-
V
L
D
D
Q
Y
--
T
-
S
S
-
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
-----
122
Blastp_CBE
69.16
38%
45
- C2 -
-
5H0H
1
HCK_HUMAN
A:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
E
D
N
E
Y
--
T
-
A
R
-
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
546
HHSearch
69.15
41%
10
- C2 -
-
5MO4
2
ABL1_HUMAN
A:
[100-479]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
----
S
----
S
GI--
N
G
S
----
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
-----
G
-----
R
V
------
Y
H
Y
R
I
N
T
A
S
D
-
G
K-
L
Y
V
-
S
-
S
-
E
-
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
-
G
L
I
-----------
T
T
L
H
-----
Y
P
-----
A
-----
P
KRNKPTVYGVSP
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
Y------
S
L
-
T
------
V
A
V
K
T
L
K
E
D
-----
E
V
E
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R-----
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
---------------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--
18
PsiBlast_PDB
69.14
40%
52
- C2 -
-
6F3F
1
SRC_MOUSE
A:
[56-438]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
-
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
LNAE
N
----
P
----
R
G
T
----
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
------
S
D
-----
F
-----
D
N
AKGLNV
K
H
Y
K
I
R
K
L
-
D
-
S
GG
F
Y
I
-
T
-
S
-
R
-
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
-
G
L
C
-------
H
R
L
T
T
V
C
P
-----
T
S
-----
K
-----
P
------------
Q
--------------------------
T
Q
GLAKD
A
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
-
E
T
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
D
N
E
Y
--
T
-
A
R
-
Q
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
7
PsiBlast_PDB
68.89
40%
23
- C2 -
-
5MO4
2
ABL1_HUMAN
A:
[102-473]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
----
S
----
S
GI--
N
G
S
----
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
-----
G
-----
R
V
------
Y
H
Y
R
I
N
T
A
-
S
-
D
GK
L
Y
V
-
S
-
S
-
E
-
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
TLHYPAP
K
R
N
K
P
T
V
Y
-----
G
V
-----
S
-----
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
----
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
---------------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
125
Blastp_CBE
68.74
38%
45
- C2 -
-
5H0B
1
HCK_HUMAN
A:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
E
D
N
E
Y
--
T
-
A
R
-
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
384
Blastp_CBE
68.72
40%
-127
- C2 -
-
4M15
2
A:
[4-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
V
I
-------
D
P
S
E
L
-
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
----
L
----
N
-------
K
D
-
K
------
V
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---
F
I
E
-
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
R
------
G
-
L
-----------------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
R
---
F
-
V
L
D
D
Q
Y
--
T
-
S
S
-
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
-----
389
Blastp_CBE
68.57
40%
-128
- C2 -
-
4M0Y
2
A:
[5-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
V
I
-------
D
P
S
E
L
-
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
----
L
----
N
-------
K
D
-
K
------
V
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---
F
I
E
-
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
R
------
G
-
L
-----------------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
R
---
F
-
V
L
D
D
Q
Y
--
T
-
S
S
-
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
-----
16
PsiBlast_PDB
68.52
40%
52
- C2 -
-
2SRC
1
SRC_HUMAN
A:
[53-435]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
-
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
LNAE
N
----
P
----
R
G
T
----
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
------
S
D
-----
F
-----
D
N
AKGLNV
K
H
Y
K
I
R
K
L
-
D
-
S
GG
F
Y
I
-
T
-
S
-
R
-
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
-
G
L
C
-------
H
R
L
T
T
V
C
P
-----
T
S
-----
K
-----
P
------------
Q
--------------------------
T
Q
GLAKD
A
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
T
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
D
N
E
Y
--
T
-
A
R
-
Q
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
124
Blastp_CBE
68.48
38%
41
- C2 -
-
5H0E
1
HCK_HUMAN
A:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
E
D
N
E
Y
--
T
-
A
R
-
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
535
HHSearch
68.44
41%
10
- C2 -
-
4XEY
1
ABL1_HUMAN
B:
[7-385]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
----
S
----
S
GI--
N
G
S
----
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
-----
G
-----
R
V
------
Y
H
Y
R
I
N
T
A
-
S
D
G
--
K
L
Y
V------
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
-
G
L
-----------
I
T
T
L
H
-----
Y
P
-----
A
-----
P
------------
K
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
------
E
V
Y
E
G
V
W
----
K
----
K
Y------
S
L
-
T
------
V
A
V
K
T
L
---
T
---
M
E
V
E
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R-----
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
-
157
Blastp_CBE
68.42
38%
41
- C2 -
-
1QCF
1
HCK_HUMAN
A:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
E
D
N
E
Y
--
T
-
A
R
-
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
123
Blastp_CBE
68.36
38%
44
- C2 -
-
5H0G
1
HCK_HUMAN
A:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
E
D
N
E
Y
--
T
-
A
R
-
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
17
PsiBlast_PDB
68.34
40%
58
- C2 -
-
1Y57
1
SRC_HUMAN
A:
[53-435]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
-
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
LNAE
N
----
P
----
R
G
T
----
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
------
S
D
-----
F
-----
D
N
AKGLNV
K
H
Y
K
I
R
K
L
-
D
-
S
GG
F
Y
I
-
T
-
S
-
R
-
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
-
G
L
C
-------
H
R
L
T
T
V
C
P
-----
T
S
-----
K
-----
P
------------
Q
--------------------------
T
Q
GLAKD
A
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
T
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
D
N
E
Y
--
T
-
A
R
-
Q
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
126
Blastp_CBE
68.03
38%
40
- C2 -
-
5H09
1
HCK_HUMAN
A:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
E
D
N
E
Y
--
T
-
A
R
-
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
385
Blastp_CBE
68.01
40%
-126
- C2 -
-
4M14
2
A:
[4-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
V
I
-------
D
P
S
E
L
-
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
----
L
----
N
-------
K
D
-
K
------
V
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---
F
I
E
-
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
R
------
G
-
L
-----------------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
R
---
F
-
V
L
D
D
Q
Y
--
T
-
S
S
-
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
-----
151
Blastp_CBE
67.97
38%
22
- C2 -
-
2C0T
1
HCK_HUMAN
B:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
-----G-
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
540
HHSearch
67.92
39%
42
- C2 -
-
2HCK
1
HCK_HUMAN
B:
[59-429]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
PGNM
L
G
S
----
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
DYDPR
Q
G
-----
D
-----
T
V
------
K
H
Y
K
I
R
T
L
D
N
-
G
--
G
F
Y
-
I
S
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
SSKPQ
K
P
-----
W
-----
E
---------------------------------------
K
D
-----
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
P
G
S
---
M
S
V
E
A
-
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
G-----
S
-
K
-----------------
Q
P
-
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
G
A
---------------
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
--
388
Blastp_CBE
67.90
40%
-125
- C2 -
-
4M0Z
2
A:
[4-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
V
I
-------
D
P
S
E
L
-
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
----
L
----
N
-------
K
D
-
K
------
V
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---
F
I
E
-
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
R
------
G
-
L
-----------------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
R
---
F
-
V
L
D
D
Q
Y
--
T
-
S
S
-
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
-----
20
PsiBlast_PDB
67.85
40%
52
- C2 -
-
1KSW
1
SRC_HUMAN
A:
[53-435]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
-
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
LNAE
N
----
P
----
R
G
T
----
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
------
S
D
-----
F
-----
D
N
AKGLNV
K
H
Y
K
I
R
K
L
-
D
-
S
GG
F
Y
I
-
T
-
S
-
R
-
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
-
G
L
C
-------
H
R
L
T
T
V
C
P
-----
T
S
-----
K
-----
P
------------
Q
--------------------------
T
Q
GLAKD
A
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
T
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
D
N
E
Y
--
T
-
A
R
-
Q
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
486
Blastp_CBE
67.84
43%
-114
- C2 -
-
3SXS
1
A:
[5-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------
K
R
E
E
I
-
T
-
L
L
K
E
L
G
S
G
Q
F
G
V
V
K
L
G
K
W
----
K
----
G
-------
Q
Y
-
D
------
V
A
V
K
M
I
K
E
G
S
M
-
S
E
--
D
E
-
F
F
Q
-
E
A
Q
T
M
M
K
L
-
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
-
H
G
------
K
-
G
-----------------
L
E
-
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
---
D
R
D
L
-----
C
V
K
V
S
D
F
G
M
T
R
---
Y
-
V
L
D
D
Q
Y
--
V
-
S
S
-
V
G
-
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
-
T
-
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
---
544
HHSearch
67.82
34%
8
- C2 -
-
4FL3
1
KSYK_HUMAN
A:
[160-633]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
A
H
E
K
M
P
W
F
H
G
K
I
S
R
E
E
S
E
Q
I
V
----
L
IGSK
T
----
N
G
K
----
F
L
I
R
A
R
D
N
-
N
G
S
Y
A
L
C
L
L
-----
H
E
-----
G
-----
K
V
------
L
H
Y
R
I
D
K
D
K
T
-
G
--
K
L
S
-
I
-
P
-
E
G
K
K
F
D
T
L
W
Q
L
V
E
H
Y
S
Y
K
A
D
-
G
L
L
-------
R
V
----
L
T
-----
V
P
-----
C
-----
Q
------------
K
-----------------------------------REALPMDTEVFESPFADPE
E
I
RPKEVYL
D
R
K
L
L
T
L
-
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
----
Q
----
M
KKV----
V
K
-
T
------
V
A
V
K
I
L
K
N
E
A
N
D
P
A
L
K
D
E
-
L
L
A
-
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
--
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
--------
H
-----------------
V
K
-
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
---
V
T
Q
H
-----
Y
A
K
I
S
D
F
G
L
S
K
---
A
-
L
R
A
----------------
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
-
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
-
140
Blastp_CBE
67.77
38%
40
- C2 -
-
3VS3
1
HCK_HUMAN
A:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
-----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
147
Blastp_CBE
67.68
38%
29
- C2 -
-
3VRZ
1
HCK_HUMAN
B:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
-----G-
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
-----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
134
Blastp_CBE
67.65
38%
37
- C2 -
-
3VS6
1
HCK_HUMAN
A:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
-----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
139
Blastp_CBE
67.64
38%
35
- C2 -
-
3VS3
1
HCK_HUMAN
B:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
-------
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
E
---------------
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
19
PsiBlast_PDB
67.63
40%
54
- C2 -
-
4K11
1
SRC_HUMAN
A:
[51-433]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
-
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
LNAE
N
----
P
----
R
G
T
----
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
------
S
D
-----
F
-----
D
N
AKGLNV
K
H
Y
K
I
R
K
L
-
D
-
S
GG
F
Y
I
-
T
-
S
-
R
-
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
-
G
L
C
-------
H
R
L
T
T
V
C
P
-----
T
S
-----
K
-----
P
------------
Q
--------------------------
T
Q
GLAKD
A
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
T
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
D
N
E
Y
--
T
-
A
R
-
Q
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
146
Blastp_CBE
67.55
38%
25
- C2 -
-
3VS0
1
HCK_HUMAN
A:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
------G-
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
488
Blastp_CBE
67.50
43%
-113
- C2 -
-
3SXR
1
BMX_HUMAN
A:
[5-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------
K
R
E
E
I
-
T
-
L
L
K
E
L
G
S
----
V
V
K
L
G
K
W
----
K
----
G
-------
Q
Y
-
D
------
V
A
V
K
M
I
K
E
G
S
M
-
S
E
--
D
E
-
F
F
Q
-
E
A
Q
T
M
M
K
L
-
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
-
H
G
------
K
-
G
-----------------
L
E
-
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
---
D
R
D
L
-----
C
V
K
V
S
D
F
G
M
T
R
---
Y
-
V
L
D
D
Q
Y
--
V
-
S
S
-
V
G
-
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
-
T
-
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
---
165
Blastp_CBE
67.41
39%
44
- C2 -
-
2HCK
1
HCK_HUMAN
A:
[61-423]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
----------------
V
-
G
A
-
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
149
Blastp_CBE
67.41
38%
41
- C2 -
-
3VRY
1
HCK_HUMAN
B:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
-----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
136
Blastp_CBE
67.34
38%
27
- C2 -
-
3VS5
1
HCK_HUMAN
A:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
-----G-
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
145
Blastp_CBE
67.26
38%
40
- C2 -
-
3VS0
1
HCK_HUMAN
B:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
164
Blastp_CBE
67.18
39%
40
- C2 -
-
2HCK
1
HCK_HUMAN
B:
[61-423]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
----------------
V
-
G
A
-
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
141
Blastp_CBE
67.12
38%
38
- C2 -
-
3VS2
1
HCK_HUMAN
B:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
154
Blastp_CBE
67.04
38%
43
- C2 -
-
2C0O
1
HCK_HUMAN
A:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
6
PsiBlast_PDB
66.95
40%
23
- C2 -
-
4XEY
1
ABL1_HUMAN
B:
[7-378]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
----
S
----
S
GI--
N
G
S
----
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
-----
G
-----
R
V
------
Y
H
Y
R
I
N
T
A
-
S
-
D
GK
L
Y
V
-------
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
TLHYPAP
K
-----------------------------------------------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
------
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
---
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
156
Blastp_CBE
66.90
38%
40
- C2 -
-
2C0I
1
HCK_HUMAN
A:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
133
Blastp_CBE
66.90
38%
41
- C2 -
-
3VS6
1
HCK_HUMAN
B:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
-----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
148
Blastp_CBE
66.87
38%
27
- C2 -
-
3VRZ
1
HCK_HUMAN
A:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
-----G-
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
487
Blastp_CBE
66.80
43%
-118
- C2 -
-
3SXR
1
B:
[5-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------
K
R
E
E
I
-
T
-
L
L
K
E
L
------
V
V
K
L
G
K
W
----
K
----
G
-------
Q
Y
-
D
------
V
A
V
K
M
I
K
E
G
S
M
-
S
E
--
D
E
-
F
F
Q
-
E
A
Q
T
M
M
K
L
-
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
-
H
G
------
K
-
G
-----------------
L
E
-
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
---
D
R
D
L
-----
C
V
K
V
S
D
F
G
M
T
R
---
Y
-
V
L
D
D
Q
Y
--
V
-
S
S
-
V
G
-
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
-
T
-
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
---
142
Blastp_CBE
66.79
38%
26
- C2 -
-
3VS2
1
HCK_HUMAN
A:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
----G-
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
153
Blastp_CBE
66.67
38%
42
- C2 -
-
2C0O
1
HCK_HUMAN
B:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
167
Blastp_CBE
66.65
39%
46
- C2 -
-
1AD5
1
HCK_HUMAN
A:
[61-423]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
----------------
V
-
G
A
-
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
152
Blastp_CBE
66.43
38%
31
- C2 -
-
2C0T
1
HCK_HUMAN
A:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
--------
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
166
Blastp_CBE
66.33
39%
43
- C2 -
-
1AD5
1
HCK_HUMAN
B:
[61-423]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
----------------
V
-
G
A
-
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
132
Blastp_CBE
66.18
38%
44
- C2 -
-
3VS7
1
HCK_HUMAN
A:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
--------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
144
Blastp_CBE
66.13
38%
38
- C2 -
-
3VS1
1
HCK_HUMAN
A:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
------------
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
135
Blastp_CBE
66.10
38%
33
- C2 -
-
3VS5
1
HCK_HUMAN
B:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
--------
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
143
Blastp_CBE
66.05
38%
42
- C2 -
-
3VS1
1
HCK_HUMAN
B:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
137
Blastp_CBE
66.05
38%
39
- C2 -
-
3VS4
1
HCK_HUMAN
B:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
-----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
138
Blastp_CBE
66.00
38%
33
- C2 -
-
3VS4
1
HCK_HUMAN
A:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
--------
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
E
----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
155
Blastp_CBE
65.90
38%
41
- C2 -
-
2C0I
1
HCK_HUMAN
B:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
-
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
493
Blastp_CBE
65.85
42%
-140
- C2 -
-
3QGW
1
ITK_HUMAN
A:
[35-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
----
L
----
N
-------
K
D
-
K
------
V
A
I
K
T
I
K
E
G
S
M
-
S
E
--
D
D
-
F
I
E
-
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
R
------
G
-
L
-----------------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
Q
-----
V
I
K
V
S
D
F
G
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
-----
150
Blastp_CBE
65.81
38%
37
- C2 -
-
3VRY
1
HCK_HUMAN
A:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
--------
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
-----------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
471
Blastp_CBE
65.63
42%
-136
- C2 -
-
1SNU
1
B:
[13-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
----
L
----
N
-------
K
D
-
K
------
V
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---
F
I
E
-
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
R
------
G
-
L
-----------------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
Q
-----
V
I
K
V
S
D
----------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
-----
130
Blastp_CBE
65.40
38%
40
- C2 -
-
4LUD
2
HCK_HUMAN
A:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
L
-
D
--G-
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
----
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
----
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
473
Blastp_CBE
65.33
42%
-140
- C2 -
-
1SM2
1
B:
[13-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
----
L
----
N
-------
K
D
-
K
------
V
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---
F
I
E
-
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
R
------
G
-
L
-----------------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
Q
-----
V
I
K
V
S
D
----------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
-----
399
Blastp_CBE
65.27
42%
-115
- C2 -
-
3MJ2
1
A:
[15-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
----
L
----
N
-------
K
D
-
K
------
V
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---
F
I
E
-
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
R
------
G
-
L
-----------------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
R
---
F
-
V
L
D
D
Q
Y
--
T
-
S
S
-
T
G
-
T
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----
538
HHSearch
64.98
34%
32
- C2 -
-
4FL2
1
KSYK_HUMAN
A:
[161-634]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
A
H
E
K
M
P
W
F
H
G
K
I
S
R
E
E
S
E
Q
I
V
----
L
IGSK
T
----
N
G
K
----
F
L
I
R
A
R
D
-
N
N
G
S
Y
A
L
C
L
L
-----
H
E
-----
G
-----
K
V
------
L
H
Y
R
I
D
K
D
K
T
-
G
--
K
L
S
-
I
-
P
-
E
G
K
K
F
D
T
L
W
Q
L
V
E
H
Y
S
Y
K
A
D
-
G
L
L
-------
R
V
----
L
T
-----
V
P
-----
C
-----
Q
------------
K
IGTQREALPMDTEVYESPYADPEEIR
P
K
-----
E
V
-------------------
Y
L
-------
D
R
K
L
L
-
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
----
Q
----
M
KKV----
V
K
-
T
------
V
A
V
K
I
L
K
N
E
A
N
D
P
A
L
K
D
E
-
L
L
A
-
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
--
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
--------
H
-----------------
V
K
-
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
---
V
T
Q
H
-----
Y
A
K
I
S
D
F
G
L
S
K
---
A
-
L
R
A
D
E
N
YY
K
-
A
Q
-
T
H
-
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
-
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
-
474
Blastp_CBE
64.98
42%
-134
- C2 -
-
1SM2
1
ITK_HUMAN
A:
[13-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
----
L
----
N
-------
K
D
-
K
------
V
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---
F
I
E
-
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
R
------
G
-
L
-----------------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
Q
-----
V
I
K
V
S
D
F
G
---------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
-----
397
Blastp_CBE
64.81
42%
-135
- C2 -
-
4MF1
1
B:
[15-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
--
G
L
V
H
L
G
Y
W
----
L
----
N
-------
K
D
-
K
------
V
A
I
K
T
I
---
A
M
-
S
E
E
D
---
F
I
E
-
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
R
------
G
-
L
-----------------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
R
-----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----
127
Blastp_CBE
64.70
38%
33
- C2 -
-
4LUE
4
HCK_HUMAN
B:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
-----G-
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
---------
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
------------------
P
I
K
W
T
A
P
E
A
I
N
---
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
492
Blastp_CBE
64.57
42%
-134
- C2 -
-
3QGW
1
B:
[35-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
----
L
----
N
-------
K
D
-
K
------
V
A
I
K
T
I
K
E
G
S
M
-
S
E
--
D
D
-
F
I
E
-
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
R
------
G
-
L
-----------------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
Q
-----
V
I
K
V
S
D
----------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
-----
131
Blastp_CBE
64.47
38%
42
- C2 -
-
3VS7
1
HCK_HUMAN
B:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
-------
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
------------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
128
Blastp_CBE
64.37
38%
45
- C2 -
-
4LUE
3
HCK_HUMAN
A:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
R
T
-----G-
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
------
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
398
Blastp_CBE
64.07
42%
-137
- C2 -
-
4MF1
1
ITK_HUMAN
A:
[15-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
--
G
L
V
H
L
G
Y
W
----
L
----
N
-------
K
D
-
K
------
V
A
I
K
T
I
---
A
M
-
S
E
E
D
---
F
I
E
-
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
R
------
G
-
L
-----------------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
Q
-----
V
I
K
V
S
D
F
G
M
--------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----
490
Blastp_CBE
64.04
42%
-126
- C2 -
-
3QGY
1
B:
[35-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
----
L
----
N
-------
K
D
-
K
------
V
A
I
K
T
I
K
E
G
S
M
-
S
E
--
D
D
-
F
I
E
-
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
R
------
G
-
L
-----------------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
-----
472
Blastp_CBE
63.93
42%
-134
- C2 -
-
1SNU
1
ITK_HUMAN
A:
[13-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
----
L
----
N
-------
K
D
-
K
------
V
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---
F
I
E
-
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
R
------
G
-
L
-----------------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
Q
-----
V
I
K
V
S
D
F
G
---------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
-
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
-----
129
Blastp_CBE
62.73
38%
38
- C2 -
-
4LUD
3
HCK_HUMAN
B:
[67-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
----
L
----
A
----
P
G
N
MLGS
F
M
I
R
D
S
E
T
---
S
Y
S
L
S
V
R
-----
D
Y
-----
D
-----
P
R
QGDTV-
K
H
Y
K
I
-----------------------
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
-
G
L
C
-------
Q
K
L
S
V
P
C
M
-----
S
S
-----
K
-----
P
------------
Q
--------------------------
K
P
WEKD-
A
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
--
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
-
S
-----------------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
536
HHSearch
62.62
33%
20
- C2 -
-
4K2R
1
ZAP70_HUMAN
A:
[155-600]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
----
Y
SGAQ
T
----
D
G
K
----
F
L
L
R
P
R
K
-
E
Q
G
T
Y
A
L
S
L
I
-----
Y
G
-----
K
-----
T
V
------
Y
H
Y
L
I
S
Q
D
K
A
-
G
--
K
Y
C
-
I
-
P
-
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
-
G
L
I
-----------
Y
C
L
K
-----
E
A
-----
C
-----
P
NSDKP-------
R
PMPMDTSVYESPYSDPEELKD-----
K
K
-----
L
F
-------------------
L
K
-------
R
D
N
L
L
-
I
-
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
----
R
MRK-
K
-------
Q
I
-
D
------
V
A
I
K
V
L
K
Q
G
T
E
-
K
A
D
T
E
E
-
M
M
R
-
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
--
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
-
K
R
------
E
-
E
-----------------
I
P
-
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
---
V
N
R
H
-----
Y
A
K
I
S
D
F
G
L
S
------------------------
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
-
K
-
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
-
528
Blastp_CBE
61.94
43%
-51
- C2 -
-
2OF4
1
LCK_HUMAN
A:
[5-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-----
E
W
-------------------
E
V
-------
P
R
E
T
L
-
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
----
N
----
G
-------
H
T
-
K
------
V
A
V
K
S
L
K
Q
G
---
S
M
S
P
D
A
-
F
L
A
-
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
--
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
S
------
G
I
K
-----------------
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
D
T
L
-----
S
C
K
I
A
D
F
G
L
A
R
---
L
-
I
E
D
N
E
Y
--
T
-
A
R
-
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
-
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
--------
478
Blastp_CBE
61.93
42%
-139
- C2 -
-
3V8T
1
ITK_HUMAN
A:
[15-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
---
G
L
V
H
L
G
Y
W
----
L
----
N
-------
K
D
-
K
------
V
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---
F
I
E
-
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
R
------
G
-
L
-----------------
F
A
-
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
Q
-----
V
I
K
V
S
D
F
G
M
--------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
--------
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
-----
515
Blastp_CBE
61.42
43%
-52
- C2 -
-
3B2W
1
LCK_HUMAN
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
V
-------
P
R
E
T
L
-
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
----
N
----
G
-------
H
T
-
K
------
V
A
V
K
S
L
K
Q
G
---
S
M
S
P
D
A
-
F
L
A
-
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
--
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
S
------
G
I
K
-----------------
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
D
T
L
-----
S
C
K
I
A
D
F
G
L
A
R
---
L
-
I
E
D
N
E
Y
--
T
-
A
---
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
-
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
--------
23
Blastp_CBE
61.39
45%
-52
- C2 -
-
3CS9
1
ABL1_HUMAN
D:
[10-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--------------------
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
537
HHSearch
61.23
33%
23
- C2 -
-
2OZO
1
ZAP70_HUMAN
A:
[154-600]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
----
Y
SGAQ
T
----
D
G
K
----
F
L
L
R
P
R
K
-
E
Q
G
T
Y
A
L
S
L
I
-----
Y
G
-----
K
-----
T
V
------
Y
H
Y
L
I
S
Q
D
K
A
-
G
--
K
Y
C
-
I
-
P
-
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
-
G
L
I
-----------
Y
C
L
K
-----
E
A
-----
C
PN----------------
M
DTSVFESPFSDPEELKD---------
K
K
-----
L
F
-------------------
L
K
-------
R
D
N
L
L
-
I
-
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
----
R
----
M
RKK----
Q
I
-
D
------
V
A
I
K
V
L
K
Q
G
T
E
-
K
A
D
T
E
E
-
M
M
R
-
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
--
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
-
K
R
------
E
-
E
-----------------
I
P
-
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
---
V
N
R
H
-----
Y
A
K
I
S
D
F
G
L
S
K
---
A
-
L
G
-----------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
-
K
-
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
-
529
Blastp_CBE
61.05
43%
-49
- C2 -
-
2OF2
1
LCK_HUMAN
A:
[5-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-----
E
W
-------------------
E
V
-------
P
R
E
T
L
-
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
----
N
----
G
-------
H
T
-
K
------
V
A
V
K
S
L
K
Q
G
---
S
M
S
P
D
A
-
F
L
A
-
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
--
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
S
------
G
I
K
-----------------
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
D
T
L
-----
S
C
K
I
A
D
F
G
L
A
R
---
L
-
I
E
D
N
E
Y
--
T
-
A
R
-
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
-
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
--------
518
Blastp_CBE
60.85
43%
-59
- C2 -
-
3BYU
1
LCK_HUMAN
A:
[11-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-----
E
W
-------------------
E
V
-------
P
R
E
T
L
-
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
----
N
----
G
-------
H
T
-
K
------
V
A
V
K
S
L
K
Q
G
---
S
M
S
P
D
A
-
F
L
A
-
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
--
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
S
------
G
I
K
-----------------
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
D
T
L
-----
S
C
K
I
A
D
F
G
L
------------------------
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
-
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
--------
249
Blastp_CBE
60.59
46%
-67
- C2 -
-
5D11
2
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
-------------
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
279
Blastp_CBE
60.55
45%
-28
- C2 -
-
5ZJ6
1
HCK_HUMAN
A:
[15-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----
W
-----
E
------------
K
--------------------------
D
A
------
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
---
K
S
------
D
-
E
GSK--------------
Q
P
-
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
E
D
N
E
Y
--
T
-
A
R
-
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
502
Blastp_CBE
60.22
43%
-68
- C2 -
-
2OG8
1
LCK_HUMAN
A:
[2-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
-------------------
E
V
-------
P
R
E
T
L
-
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
----
N
----
G
-------
H
T
-
K
------
V
A
V
K
S
L
K
Q
G
---
S
M
S
P
D
A
-
F
L
A
-
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
--
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
S
------
G
I
K
-----------------
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
D
T
L
-----
S
C
K
I
A
D
F
G
L
--------------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
-
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
--------
250
Blastp_CBE
60.20
46%
-64
- C2 -
-
5D11
2
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
-------
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
278
Blastp_CBE
60.09
45%
-28
- C2 -
-
5ZJ6
1
HCK_HUMAN
B:
[15-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----
W
-----
E
------------
K
--------------------------
D
A
------
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
---
K
S
------
D
-
E
GSK--------------
Q
P
-
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
E
D
N
E
Y
--
T
-
A
R
-
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
273
Blastp_CBE
59.98
45%
-27
- C2 -
-
2HK5
1
HCK_HUMAN
A:
[4-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----
W
-----
E
------------
K
--------------------------
D
A
------
W
-------------------
E
I
-------
P
R
E
S
L
-
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
----
N
----
K
-------
H
T
-
K
------
V
A
V
K
T
M
K
---
P
-
G
S
M
S
V
E
A
F
L
A
-
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
---
K
S
------
D
-
E
GSK--------------
Q
P
-
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
E
D
N
E
Y
--
T
-
A
R
-
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
-
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
--------
501
Blastp_CBE
59.97
43%
-59
- C2 -
-
2OG8
1
?
B:
[2-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
-------------------
E
V
-------
P
R
E
T
L
-
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
----
N
----
G
-------
H
T
-
K
------
V
A
V
K
S
L
K
Q
G
---
S
M
S
P
D
A
-
F
L
A
-
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
--
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
S
------
G
I
K
-----------------
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
D
T
L
-----
S
C
K
I
A
D
F
G
L
A
-------------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
-
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
--------
519
Blastp_CBE
59.82
43%
-61
- C2 -
-
3BYS
1
LCK_HUMAN
A:
[11-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-----
E
W
-------------------
E
V
-------
P
R
E
T
L
-
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
----
N
----
G
-------
H
T
-
K
------
V
A
V
K
S
L
K
Q
G
---
S
M
S
P
D
A
-
F
L
A
-
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
--
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
S
------
G
I
K
-----------------
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
D
T
L
-----
S
C
K
I
A
D
F
G
L
--------------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
-
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
--------
258
Blastp_CBE
59.38
46%
-62
- C2 -
-
2QQ7
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
---------------
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
244
Blastp_CBE
59.38
46%
-66
- C2 -
-
6HVF
3
?
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
--------------
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
87
Blastp_CBE
59.37
45%
-7
- C2 -
-
3MSS
2
ABL1_MOUSE
B:
[5-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
--------
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
-
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
365
Blastp_CBE
59.32
46%
-69
- C2 -
-
2HWO
2
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
-
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
--------
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
----
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
29
Blastp_CBE
59.26
45%
-8
- C2 -
-
3OY3
1
ABL1_MOUSE
B:
[3-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
28
Blastp_CBE
59.26
45%
-9
- C2 -
-
3QRJ
1
ABL1_HUMAN
A:
[12-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
-------
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
329
Blastp_CBE
59.16
46%
-16
- C2 -
-
3DQX
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
-----------
Q
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
107
Blastp_CBE
59.16
45%
-3
- C2 -
-
2QOH
1
ABL1_MOUSE
A:
[3-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
-----
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
215
Blastp_CBE
59.13
42%
-30
- C2 -
-
4D4V
2
B:
[7-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
M
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
F
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
A
T
D
-----
C
V
K
L
G
D
F
G
--------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
67
Blastp_CBE
59.15
45%
-5
- C2 -
-
6NPE
2
ABL1_HUMAN
A:
[18-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
-------
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
39
Blastp_CBE
59.13
45%
-2
- C2 -
-
3QRK
1
ABL1_HUMAN
A:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
287
Blastp_CBE
59.11
46%
-69
- C2 -
-
3QLF
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
-------------
L
Q
-
E
A
Q
V
M
K
K
I
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
---------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
306
Blastp_CBE
59.08
46%
-71
- C2 -
-
4FIC
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
---------
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
51
Blastp_CBE
58.90
45%
-5
- C2 -
-
4TWP
1
ABL1_HUMAN
A:
[2-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
-------
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
42
Blastp_CBE
58.85
45%
-9
- C2 -
-
3IK3
1
ABL1_MOUSE
B:
[3-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
507
Blastp_CBE
58.83
39%
21
- C2 -
-
4HVS
1
A:
[35-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-----
P
------------
Y
--------------------------
D
H
-----
K
W
-------------------
E
F
-------
P
R
N
R
L
-
S
-
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
----
Q
----
G
LIKSDA-
A
M
-
T
------
V
A
V
K
M
L
K
P
S
A
H
-
S
T
E
R
E
A
-
L
M
S
-
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
H
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
R
------
D
-
S
FHSSDTSPASMEDDENA
L
D
-
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
---
T
H
G
R
-----
I
T
K
I
C
D
F
G
L
A
R
---
D
I
K
N
D
S
N
Y
--
V
-
D
K
-
G
N
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
-
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
S
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
--------
360
Blastp_CBE
58.76
46%
-59
- C2 -
-
2QLQ
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
-------------------
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
72
Blastp_CBE
58.82
45%
1
- C2 -
-
2G2I
1
ABL1_HUMAN
B:
[7-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
----
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
P
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
26
Blastp_CBE
58.79
45%
-6
- C2 -
-
2HZI
1
ABL1_HUMAN
B:
[10-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
------
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
83
Blastp_CBE
58.76
45%
-4
- C2 -
-
6HD4
2
ABL1_MOUSE
B:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
-----
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
70
Blastp_CBE
58.76
45%
-2
- C2 -
-
4WA9
1
ABL1_HUMAN
B:
[7-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
69
Blastp_CBE
58.76
45%
-7
- C2 -
-
3PYY
1
ABL1_HUMAN
A:
[18-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
------
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
50
Blastp_CBE
58.73
45%
-7
- C2 -
-
4TWP
1
ABL1_HUMAN
B:
[2-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
243
Blastp_CBE
58.67
46%
-61
- C2 -
-
6HVF
2
?
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
--------------
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
-----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
44
Blastp_CBE
58.69
45%
-6
- C2 -
-
2Z60
1
ABL1_MOUSE
A:
[3-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
-----
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
27
Blastp_CBE
58.67
45%
-4
- C2 -
-
3QRJ
1
ABL1_HUMAN
B:
[11-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
251
Blastp_CBE
58.65
46%
-68
- C2 -
-
5D10
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
------------------
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
--------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
171
Blastp_CBE
58.63
41%
-8
- C2 -
-
4K9Y
1
A:
[8-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-------------------
E
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
R
---
Y
-
M
E
D
S
T
Y
--
Y
-
K
A
-
S
K
-
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
94
Blastp_CBE
58.64
45%
-4
- C2 -
-
1OPJ
2
ABL1_MOUSE
B:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
74
Blastp_CBE
58.63
45%
0
- C2 -
-
2G2H
1
ABL1_HUMAN
B:
[8-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
P
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
217
Blastp_CBE
58.61
42%
-25
- C2 -
-
4D4S
1
B:
[7-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
M
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
F
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
A
T
D
-----
C
V
K
L
G
D
F
G
L
S
R
---
Y
-
M
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
407
Blastp_CBE
58.59
40%
19
- C2 -
-
6GQM
2
A:
[30-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-----
P
------------
Y
--------------------------
D
H
-----
K
W
-------------------
E
F
-------
P
R
N
R
L
-
S
-
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
----
Q
----
G
LIKSDA-
A
M
-
T
------
V
A
V
K
M
L
K
P
S
A
H
-
S
T
E
R
E
A
-
L
M
S
-
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
H
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
R
------
D
-
E
FVPYLYKDF--------
L
T
-
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
---
T
H
G
N
-----
I
T
K
I
C
D
F
G
L
A
R
---
D
I
K
N
D
S
N
Y
--
V
-
D
K
-
G
N
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
-
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
--------
303
Blastp_CBE
58.57
46%
-26
- C2 -
-
4O2P
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
-----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
104
Blastp_CBE
58.56
45%
-4
- C2 -
-
3KF4
1
ABL1_MOUSE
B:
[3-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
---
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
85
Blastp_CBE
58.55
45%
-7
- C2 -
-
3MSS
2
ABL1_MOUSE
D:
[5-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
--------
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
-
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
113
Blastp_CBE
58.53
45%
-4
- C2 -
-
3DK3
1
ABL1_MOUSE
A:
[5-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
------
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
F
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
227
Blastp_CBE
58.47
43%
-17
- C2 -
-
4H1J
1
A:
[21-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
A
R
E
D
V
-
V
-
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
----
T
----
N
HKGE---
K
I
-
N
------
V
A
V
K
T
C
K
K
D
C
T
-
L
D
N
K
E
K
-
F
M
S
-
E
A
V
I
M
K
N
L
-
D
H
P
H
I
V
K
L
I
G
I
-
I
E
E
-
E
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
------
N
-
S
-----------------
L
K
-
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
---
A
S
P
E
-----
C
V
K
L
G
D
F
G
L
S
R
----------------
A
-
S
V
-
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
-
E
-
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
-------
88
Blastp_CBE
58.47
45%
-7
- C2 -
-
3MSS
2
ABL1_MOUSE
A:
[5-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
--------
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
-
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
105
Blastp_CBE
58.45
45%
-4
- C2 -
-
3KF4
1
ABL1_MOUSE
A:
[3-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
-------
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
89
Blastp_CBE
58.45
45%
-4
- C2 -
-
3MS9
2
ABL1_MOUSE
B:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
---
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
210
Blastp_CBE
58.42
42%
-26
- C2 -
-
4D58
1
?
B:
[7-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
M
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
F
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
A
T
D
-----
C
V
K
L
G
D
F
G
L
S
R
---
Y
-
M
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
96
Blastp_CBE
58.44
45%
-4
- C2 -
-
1M52
3
ABL1_MOUSE
B:
[10-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
314
Blastp_CBE
58.38
46%
-21
- C2 -
-
3UQF
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
78
Blastp_CBE
58.43
45%
1
- C2 -
-
2F4J
1
ABL1_HUMAN
A:
[4-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
P
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
330
Blastp_CBE
58.37
46%
-16
- C2 -
-
3DQX
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
------------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
106
Blastp_CBE
58.41
45%
-1
- C2 -
-
2QOH
1
ABL1_MOUSE
B:
[3-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
-----
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
40
Blastp_CBE
58.42
45%
-3
- C2 -
-
3QRI
1
ABL1_HUMAN
B:
[10-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
-------
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
261
Blastp_CBE
58.37
46%
-19
- C2 -
-
4MXO
1
SRC_HUMAN
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
T
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
-----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
63
Blastp_CBE
58.41
45%
-8
- C2 -
-
6NPV
2
ABL1_HUMAN
A:
[18-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
-------
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
293
Blastp_CBE
58.40
46%
-19
- C2 -
-
5XP5
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
------------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
30
Blastp_CBE
58.38
45%
-5
- C2 -
-
3OY3
1
ABL1_MOUSE
A:
[3-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
230
Blastp_CBE
58.34
47%
-20
- C2 -
-
4MXY
1
SRC_HUMAN
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
L
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
T
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
-----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
228
Blastp_CBE
58.34
47%
-20
- C2 -
-
4MXZ
1
SRC_HUMAN
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
L
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
T
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
-----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
97
Blastp_CBE
58.37
45%
0
- C2 -
-
1M52
1
ABL1_MOUSE
A:
[10-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
302
Blastp_CBE
58.36
46%
-16
- C2 -
-
4U5J
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
------------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
158
Blastp_CBE
58.34
45%
-1
- C2 -
-
3HMI
1
ABL2_HUMAN
A:
[26-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
E
-
E
-----------------
V
T
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
V
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
--------
409
Blastp_CBE
58.33
40%
18
- C2 -
-
6GQL
1
KIT_HUMAN
A:
[30-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-----
P
------------
Y
--------------------------
D
H
-----
K
W
-------------------
E
F
-------
P
R
N
R
L
-
S
-
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
----
Q
----
G
LIKSDA-
A
M
-
T
------
V
A
V
K
M
L
K
P
S
A
H
-
S
T
E
R
E
A
-
L
M
S
-
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
H
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
R
------
D
-
E
FVPYLYKDF--------
L
T
-
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
---
T
H
G
N
-----
I
T
K
I
C
D
F
G
L
A
R
---
D
I
K
N
D
S
N
Y
--
V
-
D
K
-
G
N
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
-
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
--------
82
Blastp_CBE
58.30
45%
-4
- C2 -
-
6HD6
2
ABL1_MOUSE
A:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
----
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
277
Blastp_CBE
58.26
46%
-12
- C2 -
-
3U4W
4
A:
[2-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
D
N
E
Y
--
T
-
A
R
-
Q
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
173
Blastp_CBE
58.22
41%
-36
- C2 -
-
4K8A
1
FAK1_HUMAN
A:
[7-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
-------------------
E
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSP------
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
--------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
112
Blastp_CBE
58.22
45%
-9
- C2 -
-
3DK3
1
ABL1_MOUSE
B:
[5-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
------
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
F
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
222
Blastp_CBE
58.18
42%
-28
- C2 -
-
2JKO
1
A:
[7-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
M
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
F
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
A
T
D
-----
C
V
K
L
G
D
F
G
L
-------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
189
Blastp_CBE
58.20
42%
-36
- C2 -
-
4KAO
1
B:
[10-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSP------
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
--------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
14
PsiBlast_PDB
58.18
44%
2
- C2 -
-
3CS9
1
ABL1_HUMAN
A:
[10-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
------
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
54
Blastp_CBE
58.17
45%
1
- C2 -
-
3UE4
1
ABL1_HUMAN
B:
[8-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
--
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
325
Blastp_CBE
58.14
46%
-19
- C2 -
-
3EN4
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-----------------
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
41
Blastp_CBE
58.13
45%
-0
- C2 -
-
3QRI
1
ABL1_HUMAN
A:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
353
Blastp_CBE
58.06
46%
-25
- C2 -
-
3G5D
2
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
-------
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
102
Blastp_CBE
58.12
45%
-4
- C2 -
-
3KFA
1
ABL1_MOUSE
B:
[3-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
245
Blastp_CBE
58.11
46%
-61
- C2 -
-
6HVE
1
?
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-------------
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
254
Blastp_CBE
58.09
46%
-65
- C2 -
-
3LOK
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
---
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
-----------------
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
357
Blastp_CBE
58.02
46%
-23
- C2 -
-
3F3U
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
--
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
312
Blastp_CBE
58.03
46%
-18
- C2 -
-
3UQG
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
92
Blastp_CBE
58.08
45%
-2
- C2 -
-
3K5V
2
ABL1_MOUSE
A:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
---
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
95
Blastp_CBE
58.07
45%
-2
- C2 -
-
1OPJ
2
ABL1_MOUSE
A:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
58
Blastp_CBE
58.06
45%
6
- C2 -
-
2G1T
1
ABL1_HUMAN
B:
[5-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
55
Blastp_CBE
58.06
45%
-0
- C2 -
-
3UE4
1
ABL1_HUMAN
A:
[8-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
182
Blastp_CBE
58.05
42%
-22
- C2 -
-
2IJM
1
FAK1_HUMAN
A:
[9-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
262
Blastp_CBE
58.03
46%
-20
- C2 -
-
4MXO
1
SRC_HUMAN
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
T
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
48
Blastp_CBE
58.02
45%
4
- C2 -
-
4ZOG
5
ABL1_HUMAN
A:
[5-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
223
Blastp_CBE
58.01
42%
-23
- C2 -
-
2JKK
1
?
A:
[7-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
M
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
F
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
A
T
D
-----
C
V
K
L
G
D
F
G
L
S
R
-----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
34
Blastp_CBE
58.00
45%
0
- C2 -
-
2HYY
1
ABL1_HUMAN
D:
[6-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
----
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
256
Blastp_CBE
57.99
46%
-20
- C2 -
-
3F3W
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
91
Blastp_CBE
57.98
45%
-3
- C2 -
-
3K5V
2
ABL1_MOUSE
B:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
-----
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
170
Blastp_CBE
57.95
41%
-40
- C2 -
-
4KAB
1
FAK1_HUMAN
A:
[5-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
-----
D
Y
-------------------
E
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSP------
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
---------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
159
Blastp_CBE
57.95
45%
-5
- C2 -
-
3GVU
2
ABL2_HUMAN
A:
[26-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
E
-
E
-----------------
V
T
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
V
V
K
V
A
D
F
G
L
S
R
-------
G
D
T
Y
--
T
-------
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
--------
485
Blastp_CBE
57.86
44%
-30
* C2 *
-
5XY1
1
LYN_HUMAN
A:
[7-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
I
-
K
-
L
V
K
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
----
N
----
N
-------
S
T
-
K
------
V
A
V
K
T
L
K
---
P
-
G
T
M
S
V
Q
A
F
L
E
-
E
A
N
L
M
K
T
L
-
Q
H
D
K
L
V
R
L
Y
A
V
V
T
R
E
-
E
P
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
---
K
S
------
D
-
E
GGK--------------
V
L
-
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
---
S
E
S
L
-----
M
C
K
I
A
D
F
G
L
A
R
---
V
------------------
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
-
T
-
N
A
D
V
M
T
A
L
S
Q
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
--------
292
Blastp_CBE
57.87
46%
-17
- C2 -
-
5XP5
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
------------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
344
Blastp_CBE
57.91
46%
-18
- C2 -
-
4MCV
1
SRC_CHICK
A:
[5-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
290
Blastp_CBE
57.90
46%
-15
- C2 -
-
5XP7
2
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
361
Blastp_CBE
57.82
46%
-66
- C2 -
-
2QLQ
2
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
------------------
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
---
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
220
Blastp_CBE
57.88
42%
-18
- C2 -
-
4C7T
1
A:
[7-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
M
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
F
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
A
T
D
-----
C
V
K
L
G
D
F
G
L
S
R
---
Y
-
M
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
246
Blastp_CBE
57.87
46%
-23
- C2 -
-
6HVE
1
?
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
84
Blastp_CBE
57.86
45%
-1
- C2 -
-
6HD4
3
ABL1_MOUSE
A:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
---
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
349
Blastp_CBE
57.85
46%
-20
- C2 -
-
3TZ8
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
------------------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
177
Blastp_CBE
57.80
42%
-18
- C2 -
-
2JKQ
1
A:
[7-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
172
Blastp_CBE
57.84
41%
-18
- C2 -
-
4K8A
1
B:
[7-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
-------------------
E
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
R
---
Y
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
294
Blastp_CBE
57.83
46%
-22
- C2 -
-
5K9I
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
81
Blastp_CBE
57.82
45%
-3
- C2 -
-
6HD6
1
ABL1_MOUSE
B:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
-----
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
73
Blastp_CBE
57.82
45%
6
- C2 -
-
2G2I
1
ABL1_HUMAN
A:
[5-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
---
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
P
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
103
Blastp_CBE
57.81
45%
-1
- C2 -
-
3KFA
1
ABL1_MOUSE
A:
[3-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
98
Blastp_CBE
57.80
45%
-3
- C2 -
-
1IEP
1
ABL1_MOUSE
B:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
358
Blastp_CBE
57.79
46%
-23
- C2 -
-
3F3U
2
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
110
Blastp_CBE
57.78
45%
-5
- C2 -
-
6BL8
1
ABL1_HUMAN
B:
[2-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
---
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
F
--
T
-
A
H
--
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
411
Blastp_CBE
57.70
40%
18
- C2 -
-
6GQK
1
?
A:
[30-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-----
P
------------
Y
--------------------------
D
H
-----
K
W
-------------------
E
F
-------
P
R
N
R
L
-
S
-
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
----
Q
----
G
LIKSDA-
A
M
-
T
------
V
A
V
K
M
L
K
P
S
A
H
-
S
T
E
R
E
A
-
L
M
S
-
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
H
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
R
------
D
-
E
FVPYKVAPEDLYKDF--
L
T
-
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
---
T
H
G
N
-----
I
T
K
I
C
D
F
G
L
A
R
---
D
I
K
N
D
S
N
Y
--
V
-
D
K
-
G
N
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
-
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
--------
232
Blastp_CBE
57.77
41%
-19
- C2 -
-
2J0J
1
FAK1_CHICK
A:
[379-649]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-----
P
------------
S
--------------------------
T
R
-----
D
Y
-------------------
E
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
M
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
F
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
R
---
Y
-
M
E
D
---------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
36
Blastp_CBE
57.76
45%
-4
- C2 -
-
2HYY
1
ABL1_HUMAN
B:
[6-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
-
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
99
Blastp_CBE
57.75
45%
-3
- C2 -
-
1IEP
1
ABL1_MOUSE
A:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
61
Blastp_CBE
57.75
45%
-1
- C2 -
-
2HIW
1
ABL1_HUMAN
A:
[5-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
291
Blastp_CBE
57.70
46%
-17
- C2 -
-
5XP7
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
-----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
216
Blastp_CBE
57.74
42%
-20
- C2 -
-
4D4V
2
FAK1_CHICK
A:
[7-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
M
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
F
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
A
T
D
-----
C
V
K
L
G
D
F
-------------------------
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
100
Blastp_CBE
57.73
45%
-2
- C2 -
-
1FPU
1
ABL1_MOUSE
B:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---------
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
338
Blastp_CBE
57.67
46%
-16
- C2 -
-
3SVV
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
C
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
59
Blastp_CBE
57.73
45%
3
- C2 -
-
2G1T
1
ABL1_HUMAN
A:
[7-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
289
Blastp_CBE
57.71
46%
-19
- C2 -
-
3OEZ
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
I
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
184
Blastp_CBE
57.70
42%
-8
- C2 -
-
2ETM
1
FAK1_HUMAN
A:
[9-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
R
---
Y
-
M
E
---------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
180
Blastp_CBE
57.67
42%
-20
- C2 -
-
6I8Z
1
A:
[9-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
R
-----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
161
Blastp_CBE
57.67
45%
-5
- C2 -
-
2XYN
4
ABL2_HUMAN
B:
[26-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
--
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
E
-
E
-----------------
V
T
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
V
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
--------
80
Blastp_CBE
57.68
45%
-7
- C2 -
-
2E2B
1
ABL1_HUMAN
A:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
------
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-----
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
350
Blastp_CBE
57.61
46%
-21
- C2 -
-
3TZ8
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
86
Blastp_CBE
57.67
45%
-4
- C2 -
-
3MSS
2
ABL1_MOUSE
C:
[5-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
--------
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
-
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
236
Blastp_CBE
57.63
41%
-19
- C2 -
-
2J0K
1
FAK1_CHICK
B:
[379-649]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-----
P
------------
S
--------------------------
T
R
-----
D
Y
-------------------
E
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
M
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
F
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
A
T
D
-----
C
V
K
L
G
D
F
G
L
S
R
-----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
199
Blastp_CBE
57.65
43%
-16
- C2 -
-
3FZS
1
A:
[5-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
A
R
E
D
V
-
V
-
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
----
T
----
N
HKGE---
K
I
-
N
------
V
A
V
K
T
C
K
K
D
C
T
-
L
D
N
K
E
K
-
F
M
S
-
E
A
V
I
M
K
N
L
-
D
H
P
H
I
V
K
L
I
G
I
-
I
E
E
-
E
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
------
N
-
S
-----------------
L
K
-
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
---
A
S
P
E
-----
C
V
K
L
G
D
F
G
--------------------------
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
-
E
-
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
-------
197
Blastp_CBE
57.62
43%
-16
- C2 -
-
3H3C
1
A:
[5-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
A
R
E
D
V
-
V
-
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
----
T
----
N
HKGE---
K
I
-
N
------
V
A
V
K
T
C
K
K
D
C
T
-
L
D
N
K
E
K
-
F
M
S
-
E
A
V
I
M
K
N
L
-
D
H
P
H
I
V
K
L
I
G
I
-
I
E
E
-
E
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
------
N
-
S
-----------------
L
K
-
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
---
A
S
P
E
-----
C
V
K
L
G
D
F
G
L
-----------------------
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
-
E
-
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
-------
160
Blastp_CBE
57.64
45%
-8
- C2 -
-
2XYN
4
ABL2_HUMAN
C:
[27-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
--
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
E
-
E
-----------------
V
T
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
V
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
--------
175
Blastp_CBE
57.63
41%
-36
- C2 -
-
4GU9
1
FAK1_HUMAN
A:
[7-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
-------------------
E
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSP------
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
---------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
121
Blastp_CBE
57.62
45%
-6
- C2 -
-
4XLI
1
ABL2_MOUSE
A:
[2-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
------
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
S
R
------
E
-
E
-----------------
V
T
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
V
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
--------
333
Blastp_CBE
57.61
46%
-16
- C2 -
-
2OIQ
2
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
---------------------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
75
Blastp_CBE
57.60
45%
6
- C2 -
-
2G2H
1
ABL1_HUMAN
A:
[8-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
P
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
363
Blastp_CBE
57.53
46%
-70
- C2 -
-
2HWP
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
---
V
K
L
G
Q
G
C
-
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
--------------
F
L
Q
--
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
---
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
---------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
364
Blastp_CBE
57.59
46%
-60
- C2 -
-
2HWO
2
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
------------------
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
362
Blastp_CBE
57.58
46%
-74
- C2 -
-
2HWP
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
-------------------
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
-----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
65
Blastp_CBE
57.57
45%
-3
- C2 -
-
6NPU
2
ABL1_HUMAN
A:
[18-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
-------
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
162
Blastp_CBE
57.56
45%
-8
- C2 -
-
2XYN
2
ABL2_HUMAN
A:
[26-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
--
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
E
-
E
-----------------
V
T
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
V
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
--------
406
Blastp_CBE
57.48
40%
26
- C2 -
-
6GQM
1
?
B:
[31-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
Y
--------------------------
D
H
-----
K
W
-------------------
E
F
-------
P
R
N
R
L
-
S
-
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
----
Q
----
G
LIKSDA-
A
M
-
T
------
V
A
V
K
M
L
K
P
S
A
H
-
S
T
E
R
E
A
-
L
M
S
-
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
H
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
R
------
D
-
E
FVPYKKDF---------
L
T
-
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
---
T
H
G
N
-----
I
T
K
I
C
D
F
G
L
A
R
---
D
I
K
N
D
S
N
Y
--
V
-
D
K
-
G
N
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
-
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
--------
368
Blastp_CBE
57.48
46%
-17
- C2 -
-
5T0P
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
C
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
239
Blastp_CBE
57.54
46%
-13
- C2 -
-
2BDF
1
SRC_HUMAN
B:
[6-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
T
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
--------------
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
174
Blastp_CBE
57.53
41%
-30
- C2 -
-
4GU9
1
B:
[8-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-------------------
E
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSP------
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
R
---
Y
-
M
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
307
Blastp_CBE
57.52
46%
-13
- C2 -
-
4DGG
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-------A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
317
Blastp_CBE
57.50
46%
-16
- C2 -
-
3F6X
1
SRC_CHICK
D:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
---------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
359
Blastp_CBE
57.49
46%
-24
- C2 -
-
3F3T
2
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
56
Blastp_CBE
57.48
45%
9
- C2 -
-
2G1T
1
ABL1_HUMAN
D:
[5-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
255
Blastp_CBE
57.42
46%
-19
- C2 -
-
3F3W
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
513
Blastp_CBE
57.35
41%
11
- C2 -
-
4UXL
1
A:
[30-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-------
P
R
E
K
L
-
T
-
L
R
L
L
L
G
S
G
A
F
G
E
V
Y
E
G
T
A
----
V
----
D
ILGVGSG
E
I
-
K
------
V
A
V
K
T
L
K
K
G
S
T
-
D
Q
E
K
I
E
-
F
L
K
-
E
A
H
L
M
S
K
F
-
N
H
P
N
I
L
K
Q
L
G
V
C
L
L
N
-
E
P
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
-
A
R
MATFYG
P
-
L
-----------------
L
T
-
L
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
---
S
V
K
D
YTSPR
I
V
K
I
G
D
F
G
L
A
R
---
D
I
Y
K
------------
E
-
G
L
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
Q
P
Y
P
A
H
-
S
-
N
L
D
V
L
N
Y
V
Q
T
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
Q
L
Q
L
F
R
----
90
Blastp_CBE
57.43
45%
-7
- C2 -
-
3MS9
2
ABL1_MOUSE
A:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
--------
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
---
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
60
Blastp_CBE
57.42
45%
5
- C2 -
-
2HIW
1
ABL1_HUMAN
B:
[5-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
257
Blastp_CBE
57.41
46%
-59
- C2 -
-
2QQ7
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
------------------
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
--------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
209
Blastp_CBE
57.40
42%
-24
- C2 -
-
4D5H
1
FAK1_CHICK
A:
[7-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
M
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
F
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
A
T
D
-----
C
V
K
L
G
D
F
--------------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
234
Blastp_CBE
57.36
46%
-16
- C2 -
-
3GEQ
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
354
Blastp_CBE
57.33
46%
-23
- C2 -
-
3G5D
2
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
---------
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
301
Blastp_CBE
57.37
46%
-8
- C2 -
-
4U5J
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
------------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
233
Blastp_CBE
57.33
46%
-17
- C2 -
-
3GEQ
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
194
Blastp_CBE
57.36
42%
-15
- C2 -
-
3PXK
1
FAK1_HUMAN
A:
[10-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
--------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
13
PsiBlast_PDB
57.35
44%
1
- C2 -
-
2HZI
1
ABL1_HUMAN
A:
[10-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
242
Blastp_CBE
57.30
46%
-17
- C2 -
-
4MXX
1
SRC_HUMAN
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
T
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
T
D
F
G
L
A
R
---
L
-
I
E
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
46
Blastp_CBE
57.34
45%
-3
- C2 -
-
2HZ0
1
ABL1_HUMAN
A:
[6-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
221
Blastp_CBE
57.31
42%
-16
- C2 -
-
4BRX
1
FAK1_CHICK
A:
[7-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
-
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
M
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
F
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
A
T
D
-----
C
V
K
L
G
D
F
G
L
S
R
---
Y
-
M
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
37
Blastp_CBE
57.33
45%
-4
- C2 -
-
2HYY
1
ABL1_HUMAN
A:
[8-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
-
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
35
Blastp_CBE
57.31
45%
-3
- C2 -
-
2HYY
1
ABL1_HUMAN
C:
[6-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
-
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
---
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
187
Blastp_CBE
57.30
42%
-38
- C2 -
-
4I4E
1
A:
[12-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSP-
N
----
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
---------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
322
Blastp_CBE
57.29
46%
-73
- C2 -
-
3EN6
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
--
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
------------------
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-----
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
-----------------------------
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
200
Blastp_CBE
57.28
43%
-15
- C2 -
-
3FZR
1
A:
[5-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
A
R
E
D
V
-
V
-
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
----
T
----
N
HKGE---
K
I
-
N
------
V
A
V
K
T
C
K
K
D
C
T
-
L
D
N
K
E
K
-
F
M
S
-
E
A
V
I
M
K
N
L
-
D
H
P
H
I
V
K
L
I
G
I
-
I
E
E
-
E
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
------
N
-
S
-----------------
L
K
-
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
---
A
S
P
E
-----
C
V
K
L
G
D
F
G
L
S
R
---------------------
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
-
E
-
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
-------
319
Blastp_CBE
57.19
46%
-16
- C2 -
-
3F6X
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
-
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
----------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
101
Blastp_CBE
57.23
45%
2
- C2 -
-
1FPU
1
ABL1_MOUSE
A:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
226
Blastp_CBE
57.19
43%
-16
- C2 -
-
4H1M
1
A:
[21-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
A
R
E
D
V
-
V
-
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
----
T
----
N
HKGE---
K
I
-
N
------
V
A
V
K
T
C
K
K
D
C
T
-
L
D
N
K
E
K
-
F
M
S
-
E
A
V
I
M
K
N
L
-
D
H
P
H
I
V
K
L
I
G
I
-
I
E
E
-
E
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
------
N
-
S
-----------------
L
K
-
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
---
A
S
P
E
-----
C
V
K
L
G
D
F
G
L
S
------------------------
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
-
E
-
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
-------
169
Blastp_CBE
57.22
41%
-17
- C2 -
-
4KAB
1
B:
[7-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
-------------------
E
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE-----
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
R
---
Y
-
M
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
205
Blastp_CBE
57.20
42%
-17
- C2 -
-
6GCX
1
FAK1_CHICK
A:
[7-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
M
-
A
------
V
A
I
K
T
C
K
N
--
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
F
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
A
T
D
-----
C
V
K
L
G
D
F
G
L
S
R
-----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
43
Blastp_CBE
57.19
45%
-8
- C2 -
-
3IK3
1
ABL1_MOUSE
A:
[3-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
----------
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
327
Blastp_CBE
57.09
46%
-12
- C2 -
-
3EL8
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
248
Blastp_CBE
57.14
46%
-16
- C2 -
-
5D12
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
---------
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
-----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
238
Blastp_CBE
57.09
46%
-18
- C2 -
-
2BDJ
1
SRC_HUMAN
A:
[6-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
T
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
231
Blastp_CBE
57.09
47%
-21
- C2 -
-
4MXY
1
SRC_HUMAN
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
L
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
T
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
57
Blastp_CBE
57.12
45%
8
- C2 -
-
2G1T
1
ABL1_HUMAN
C:
[7-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
311
Blastp_CBE
57.11
46%
-20
- C2 -
-
3UQG
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
----
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
--------
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
176
Blastp_CBE
57.10
42%
-14
- C2 -
-
2JKM
1
A:
[7-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
M
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
R
-----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
229
Blastp_CBE
57.09
47%
-21
- C2 -
-
4MXZ
1
SRC_HUMAN
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
L
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
T
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
79
Blastp_CBE
57.07
45%
-7
- C2 -
-
2E2B
1
ABL1_HUMAN
B:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
-------
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
----------
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
369
Blastp_CBE
57.06
46%
-18
- C2 -
-
5T0P
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
C
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
347
Blastp_CBE
57.05
46%
-20
- C2 -
-
3TZ9
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
---------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
410
Blastp_CBE
56.97
40%
22
- C2 -
-
6GQK
1
?
B:
[30-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-----
P
------------
Y
--------------------------
D
H
-----
K
W
-------------------
E
F
-------
P
R
N
R
L
-
S
-
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
----
Q
----
G
LIKSDA-
A
M
-
T
------
V
A
V
K
M
L
K
P
S
A
H
-
S
T
E
R
E
A
-
L
M
S
-
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
H
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
R
------
D
-
E
FVPYKVDF---------
L
T
-
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
---
T
H
G
N
-----
I
T
K
I
C
D
F
G
L
A
R
---
D
I
K
N
D
S
N
Y
--
V
-
D
K
-
G
N
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
-
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
--------
181
Blastp_CBE
56.97
42%
-19
- C2 -
-
2IJM
1
B:
[9-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
506
Blastp_CBE
56.86
42%
-1
- C2 -
-
6IN0
2
?
A:
[5-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------
D
A
T
N
I
-
S
-
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
----
K
LPSK
K
-------
E
I
-
S
------
V
A
I
K
T
L
K
V
G
Y
T
-
E
K
Q
R
R
D
-
F
L
G
-
E
A
S
I
M
G
Q
F
-
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
-
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
-
H
D
------
A
-
Q
-----------------
F
T
-
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VL---------------------
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
-
S
-
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
------------
198
Blastp_CBE
56.93
43%
-13
- C2 -
-
3FZT
1
A:
[5-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
A
R
E
D
V
-
V
-
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
----
T
----
N
HKGE---
K
I
-
N
------
V
A
V
K
T
C
K
K
D
C
T
-
L
D
N
K
E
K
-
F
M
S
-
E
A
V
I
M
K
N
L
-
D
H
P
H
I
V
K
L
I
G
I
-
I
E
E
-
E
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
------
N
-
S
-----------------
L
K
-
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
---
A
S
P
E
-----
C
V
K
L
G
D
F
G
L
S
R
---------------------
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
-
E
-
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
-------
468
Blastp_CBE
56.83
43%
-9
- C2 -
-
2ZV8
1
LYN_MOUSE
A:
[5-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----
A
W
-------------------
E
I
-------
P
R
E
S
I
-
K
-
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
----
N
----
N
-------
S
T
-
K
------
V
A
V
K
T
L
K
---
P
-
G
T
M
S
V
Q
A
F
L
E
-
E
A
N
L
M
K
T
L
-
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
G
K
-----------------
V
L
-
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
---
S
E
S
L
-----
M
C
K
I
A
D
F
G
L
A
R
---
V
-
I
----------
R
-
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
-
T
-
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
--------
225
Blastp_CBE
56.88
43%
-23
- C2 -
-
5TO8
1
A:
[10-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
A
R
E
D
V
-
V
-
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
----
T
----
N
HKGE---
K
I
-
N
------
V
A
V
K
T
C
K
K
D
C
T
---
N
K
E
K
-
F
M
S
-
E
A
V
I
M
K
N
L
-
D
H
P
H
I
V
K
L
I
G
I
-
I
---
E
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
------
N
-
S
-----------------
L
K
-
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
--
C
V
H
R
D
I
A
V
R
N
I
L
V
---
A
S
P
E
-----
C
V
K
L
G
D
F
G
L
S
R
-------------------------
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
-
E
-
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
-------
253
Blastp_CBE
56.86
46%
-64
- C2 -
-
3LOK
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
--------------------
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
--------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
76
Blastp_CBE
56.89
45%
8
- C2 -
-
2G2F
1
ABL1_HUMAN
B:
[9-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
-----
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
P
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
47
Blastp_CBE
56.89
45%
-1
- C2 -
-
4ZOG
2
ABL1_HUMAN
B:
[6-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
----
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
178
Blastp_CBE
56.86
42%
-24
- C2 -
-
2J0M
1
?
B:
[7-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
L
-------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
12
PsiBlast_PDB
56.88
50%
-17
- C2 -
-
4CSV
1
?
A:
[5-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
------
W
-------------------
E
I
-------
P
R
S
E
I
-
T
-
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
----
R
----
N
Y------
N
I
-
E
------
V
A
V
K
T
L
K
E
G
T
----
M
S
V
E
E
F
L
Q
-
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
-
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C----------------------------
V
N
-
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
N
-----
V
V
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
-
S
-
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
-------------
356
Blastp_CBE
56.87
46%
-18
- C2 -
-
3F3V
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
372
Blastp_CBE
56.79
46%
-19
- C2 -
-
5SYS
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
373
Blastp_CBE
56.85
46%
-19
- C2 -
-
5SYS
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
297
Blastp_CBE
56.83
46%
-18
- C2 -
-
5J5S
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
193
Blastp_CBE
56.82
42%
-16
- C2 -
-
3PXK
1
B:
[10-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
L
-------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
517
Blastp_CBE
56.71
43%
-59
- C2 -
-
2OFV
1
LCK_HUMAN
A:
[10-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-----
E
W
-------------------
E
V
-------
P
R
E
T
L
-
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
----
N
----
G
-------
H
T
-
K
------
V
A
V
K
S
L
K
Q
G
-----------
L
A
-
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
--
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
S
------
G
I
K
-----------------
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
D
T
L
-----
S
C
K
I
A
D
F
G
L
A
--------------------------
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
-
T
-
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
--------
343
Blastp_CBE
56.80
46%
-14
- C2 -
-
4MCV
1
SRC_CHICK
B:
[5-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
--
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
----------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
21
Blastp_CBE
56.79
40%
-0
- C2 -
-
4XEY
1
ABL1_HUMAN
A:
[116-378]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
----
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
413
Blastp_CBE
56.77
40%
27
- C2 -
-
6GQJ
1
?
A:
[30-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-----
P
------------
Y
--------------------------
D
H
-----
K
W
-------------------
E
F
-------
P
R
N
R
L
-
S
-
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
----
Q
----
G
LIKSDA-
A
M
-
T
------
V
A
V
K
M
L
K
P
S
A
H
-
S
T
E
R
E
A
-
L
M
S
-
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
H
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
R
------
D
-
E
FVPYKKDF---------
L
T
-
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
---
T
H
G
N
-----
I
T
K
I
C
D
F
G
L
A
R
---
D
I
K
N
D
S
N
Y
--
V
-
D
K
-
G
N
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
-
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
--------
183
Blastp_CBE
56.73
42%
-15
- C2 -
-
2ETM
1
B:
[9-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
R
-----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
201
Blastp_CBE
56.71
43%
-13
- C2 -
-
3FZP
1
A:
[5-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
A
R
E
D
V
-
V
-
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
----
T
----
N
HKGE---
K
I
-
N
------
V
A
V
K
T
C
K
K
D
C
T
-
L
D
N
K
E
K
-
F
M
S
-
E
A
V
I
M
K
N
L
-
D
H
P
H
I
V
K
L
I
G
I
-
I
E
E
-
E
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
------
N
-
S
-----------------
L
K
-
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
---
A
S
P
E
-----
C
V
K
L
G
D
F
G
------------------------
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
-
E
-
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
-------
179
Blastp_CBE
56.70
42%
-31
- C2 -
-
3BZ3
1
A:
[4-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSP---------------
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
R
---
Y
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
497
Blastp_CBE
56.60
42%
-0
- C2 -
-
4MKC
3
A:
[68-334]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
P
R
K
N
I
-
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----
S
----------------SPLQ--
V
A
V
K
T
L
P
E
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
-
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-
T
R
PRPSQP
S
-
S
-----------------
L
A
-
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
G
Y
Y
--
R
-
K
G
-
G
C
-
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
-
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
--------------
274
Blastp_CBE
56.66
46%
-21
- C2 -
-
3G6H
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
--------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
188
Blastp_CBE
56.63
42%
-30
- C2 -
-
1MP8
1
A:
[12-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSP------
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
----------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
49
Blastp_CBE
56.61
45%
-10
- C2 -
-
3OXZ
1
ABL1_MOUSE
A:
[3-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
--------
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
-----------------
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
489
Blastp_CBE
56.60
42%
-14
- C2 -
-
4Z55
3
A:
[40-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
P
R
K
N
I
-
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
---------------------SPLQ--
V
A
V
K
T
L
P
E
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
-
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-
T
R
PRP-----------------------
L
A
-
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
G
Y
Y
----
K
G
-
G
C
-
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
-
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
--------------
111
Blastp_CBE
56.55
45%
4
- C2 -
-
6BL8
1
ABL1_HUMAN
A:
[2-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
F
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
202
Blastp_CBE
56.54
43%
-17
- C2 -
-
3ET7
1
A:
[5-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
A
R
E
D
V
-
V
-
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
----
T
----
N
HKGE---
K
I
-
N
------
V
A
V
K
T
C
K
K
D
C
T
-
L
D
N
K
E
K
-
F
M
S
-
E
A
V
I
M
K
N
L
-
D
H
P
H
I
V
K
L
I
G
I
-
I
E
E
-
E
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
------
N
-
S
-----------------
L
K
-
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
---
A
S
P
E
-----
C
V
K
L
G
D
F
G
L
S
R
---------------------
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
-
E
-
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
-------
318
Blastp_CBE
56.51
46%
-10
- C2 -
-
3F6X
1
SRC_CHICK
C:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-----
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
---------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
412
Blastp_CBE
56.49
40%
42
- C2 -
-
6GQJ
1
?
B:
[30-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-----
P
------------
Y
--------------------------
D
H
-----
K
W
-------------------
E
F
-------
P
R
N
R
L
-
S
-
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
----
Q
----
G
LIKSDA-
A
M
-
T
------
V
A
V
K
M
L
K
P
S
A
H
-
S
T
E
R
E
A
-
L
M
S
-
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
H
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
R
------
D
-
E
FVPYKDF----------
L
T
-
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
---
T
H
G
N
-----
I
T
K
I
C
D
F
G
L
A
R
---
D
I
K
N
D
S
N
Y
--
V
-
D
K
-
G
N
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
-
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
--------
375
Blastp_CBE
56.41
46%
-13
- C2 -
-
5SWH
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
514
Blastp_CBE
56.37
41%
17
- C2 -
-
3ZBF
1
A:
[30-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-------
P
R
E
K
L
-
T
-
L
R
L
L
L
G
S
---
G
E
V
Y
E
G
T
A
----
V
----
D
ILGVGSG
E
I
-
K
------
V
A
V
K
T
L
K
K
G
S
T
-
D
Q
E
K
I
E
-
F
L
K
-
E
A
H
L
M
S
K
F
-
N
H
P
N
I
L
K
Q
L
G
V
C
L
L
N
-
E
P
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
-
A
R
MATFYG
P
-
L
-----------------
L
T
-
L
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
---
S
V
K
D
YTSPR
I
V
K
I
G
D
F
G
L
A
R
---
D
I
Y
-----------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
Q
P
Y
P
A
H
-
S
-
N
L
D
V
L
N
Y
V
Q
T
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
Q
L
Q
L
F
R
----
466
Blastp_CBE
56.36
43%
-2
- C2 -
-
2ZVA
1
LYN_MOUSE
A:
[5-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----
A
W
-------------------
E
I
-------
P
R
E
S
I
-
K
-
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
----
N
----
N
-------
S
T
-
K
------
V
A
V
K
T
L
K
---
P
-
G
T
M
S
V
Q
A
F
L
E
-
E
A
N
L
M
K
T
L
-
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
G
K
-----------------
V
L
-
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
---
S
E
S
L
-----
M
C
K
I
A
D
F
G
L
A
R
---
V
-
I
E
------
T
-
A
R
-
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
-
T
-
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
--------
120
Blastp_CBE
56.41
45%
0
- C2 -
-
4XLI
1
B:
[2-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
----
G
E
V
Y
V
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
S
R
------
E
-
E
-----------------
V
T
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
V
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
--------
498
Blastp_CBE
56.30
42%
-1
- C2 -
-
3L9P
4
A:
[68-334]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
P
R
K
N
I
-
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----
S
----
G
-----------SPLQ--
V
A
V
K
T
L
P
E
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
-
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-
T
R
PRPSQP
S
-
S
-----------------
L
A
-
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
G
Y
Y
--
R
-
K
G
-
G
C
-
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
-
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
--------------
288
Blastp_CBE
56.37
46%
-16
- C2 -
-
3OEZ
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
I
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
53
Blastp_CBE
56.36
45%
-1
- C2 -
-
4YC8
3
ABL1_HUMAN
A:
[8-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
------
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
------
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
316
Blastp_CBE
56.30
46%
-11
- C2 -
-
3G6G
2
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
----------------------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
241
Blastp_CBE
56.35
46%
-11
- C2 -
-
4MXX
1
SRC_HUMAN
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
T
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
T
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
434
Blastp_CBE
56.34
44%
15
- C2 -
-
5NKG
1
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-------
S
S
-
G
KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
--
T
-
T
S
-
G
G
-
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
185
Blastp_CBE
56.33
42%
-27
- C2 -
-
4Q9S
1
A:
[12-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSP------
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
----------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
326
Blastp_CBE
56.32
46%
-21
- C2 -
-
3EN4
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
---
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
524
Blastp_CBE
56.22
42%
-7
- C2 -
-
4FOD
2
A:
[34-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
P
R
K
N
I
-
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----
S
----------------SPLQ--
V
A
V
K
T
L
P
E
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
-
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-
T
R
PRPSQP
S
-
S
-----------------
L
A
-
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
-----------
C
-
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
-
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
--------------
11
PsiBlast_PDB
56.30
50%
-2
- C2 -
-
4UEU
1
?
A:
[3-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
--------------------------
D
K
------
W
-------------------
E
I
-------
P
R
S
E
I
-
T
-
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
----
R
----
N
Y------
N
I
-
E
------
V
A
V
K
T
L
K
E
G
T
----
M
S
V
E
E
F
L
Q
-
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
-
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
E
G
------
H
-
T
-----------------
V
N
-
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
N
-----
V
V
K
V
A
D
F
G
L
A
R
---
L
-
I
---------------
A
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
-
S
-
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
-------------
394
Blastp_CBE
56.26
46%
-27
- C2 -
-
2DQ7
1
X:
[4-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
Q
-
L
I
K
R
L
G
N
G
Q
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
N
T
-
K
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
S
F
L
E
-
E
A
Q
I
M
K
K
L
-
K
H
D
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
D
-
G
E
------
G
-
R
A----------------
L
K
-
L
P
N
L
V
D
M
A
A
Q
V
A
A
G
M
A
Y
I
E
R
M
N
Y
I
H
R
D
L
R
S
A
N
I
L
V
---
G
N
G
L
-----
I
C
K
I
A
D
F
G
L
A
R
---
L
-
I
E
D
N
E
T
--
A
-
R
Q
-
G
A
-
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
V
T
K
G
R
V
P
Y
P
G
M
-
N
-
N
R
E
V
L
E
Q
V
E
R
G
Y
R
M
P
C
P
Q
D
C
P
I
S
L
H
E
L
M
I
H
C
W
K
K
D
P
E
E
R
P
T
F
E
Y
L
Q
S
F
L
--------
331
Blastp_CBE
56.19
46%
-11
- C2 -
-
3D7T
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
----------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
300
Blastp_CBE
56.22
46%
-12
- C2 -
-
4YBJ
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
340
Blastp_CBE
56.21
47%
-7
- C2 -
-
5D7V
3
PTK6_HUMAN
C:
[6-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
F
-
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
----
K
----
D
-------
R
V
-
Q
------
V
A
I
K
V
I
S
R
D
---
N
L
L
H
Q
Q
-
M
L
Q
S
E
I
Q
A
M
K
K
L
-
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
-
D
P
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
-
S
D
------
E
-
K
V----------------
L
P
-
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
---
G
E
N
T
-----
L
C
K
V
G
D
F
G
L
A
R
---
L
-
I
K
E
D
V
Y
--
L
-
S
H
-
D
--
H
N
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
-
S
-
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
-------
320
Blastp_CBE
56.15
46%
-14
- C2 -
-
3F6X
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
---------
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
---------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
284
Blastp_CBE
56.19
46%
-11
- C2 -
-
3QLG
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
---------
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
I
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
367
Blastp_CBE
56.17
47%
-13
- C2 -
-
6CZ3
1
PTK6_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
F
-
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
----
K
----
D
-------
R
V
-
Q
------
V
A
I
K
V
I
S
R
D
---
N
L
L
H
Q
Q
-
M
L
Q
S
E
I
Q
A
M
K
K
L
-
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
-
D
P
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
-
S
D
------
E
-
K
V----------------
L
P
-
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
---
G
E
N
T
-----
L
C
K
V
G
D
F
G
L
A
R
---
L
-
I
K
E
D
V
Y
--
L
-
S
H
-
D
--
H
N
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
-
S
-
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
C
F
K
A
L
R
E
R
L
S
-------
408
Blastp_CBE
56.16
40%
35
- C2 -
-
6GQL
1
KIT_HUMAN
B:
[31-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
Y
--------------------------
D
H
-----
K
W
-------------------
E
F
-------
P
R
N
R
L
-
S
-
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
----
Q
----
G
LIKSDA-
A
M
-
T
------
V
A
V
K
M
L
K
P
S
A
H
-
S
T
E
R
E
A
-
L
M
S
-
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
H
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
R
------
D
-
E
FVPYKF-----------
L
T
-
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
---
T
H
G
N
-----
I
T
K
I
C
D
F
G
L
A
R
---
D
I
K
N
D
S
N
Y
--
V
-
D
K
-
G
N
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
-
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
--------
286
Blastp_CBE
56.15
46%
-13
- C2 -
-
3QLF
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
---
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
I
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
-------------------------
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
224
Blastp_CBE
56.13
43%
-21
- C2 -
-
5TOB
1
A:
[10-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
A
R
E
D
V
-
V
-
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
----
T
-----HKGE---
K
I
-
N
------
V
A
V
K
T
C
K
------
D
N
K
E
K
-
F
M
S
-
E
A
V
I
M
K
N
L
-
D
H
P
H
I
V
K
L
I
G
I
-
I
---
E
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
-
N
K
------
N
-
S
-----------------
L
K
-
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
---
A
S
P
E
-----
C
V
K
L
G
D
F
G
---------------------------
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
-
E
-
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
-------
195
Blastp_CBE
56.12
42%
-20
- C2 -
-
4EBW
1
A:
[35-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MS--
N
----
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
L
------------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
516
Blastp_CBE
56.01
43%
-56
- C2 -
-
2OFV
1
?
B:
[10-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-----
E
W
-------------------
E
V
-------
P
R
E
T
L
-
K
-
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
----
N
----
G
-------
H
T
-
K
------
V
A
V
K
S
L
K
Q
G
--------
A
-
F
L
A
-
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
--
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
-
P
S
------
G
I
K
-----------------
L
T
-
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
D
T
L
-----
S
C
K
I
A
D
F
G
L
A
R
---
L
-
I
E
D
----------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
---------
I
Q
N
L
E
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
--------
366
Blastp_CBE
56.09
47%
-10
- C2 -
-
6CZ4
1
PTK6_HUMAN
A:
[10-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
F
-
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
----
K
----
D
-------
R
V
-
Q
------
V
A
I
K
V
I
S
R
D
---
N
L
L
H
Q
Q
-
M
L
Q
S
E
I
Q
A
M
K
K
L
-
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
-
D
P
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
-
S
D
------
E
-
K
V----------------
L
P
-
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
---
G
E
N
T
-----
L
C
K
V
G
D
F
G
L
A
R
---
L
-
I
K
E
D
V
Y
--
L
-
S
H
-------
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
-
S
-
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
C
F
K
A
L
R
E
R
L
S
-------
374
Blastp_CBE
56.06
46%
-13
- C2 -
-
5SWH
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
503
Blastp_CBE
56.05
42%
-3
- C2 -
-
4CLJ
1
A:
[27-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
P
R
K
N
I
-
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
---------------------SPLQ--
V
A
V
K
T
L
P
E
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
-
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-
T
R
PRPSQP
S
-
S
-----------------
L
A
-
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
---------
G
-
G
C
-
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
-
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
--------------
38
Blastp_CBE
56.04
45%
0
- C2 -
-
5HU9
13
ABL1_HUMAN
A:
[7-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
-------------
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
467
Blastp_CBE
56.01
43%
-7
- C2 -
-
2ZV9
1
LYN_MOUSE
A:
[5-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----
A
W
-------------------
E
I
-------
P
R
E
S
I
-
K
-
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
----
N
----
N
-------
S
T
-
K
------
V
A
V
K
T
L
K
---
P
-
G
T
M
S
V
Q
A
F
L
E
-
E
A
N
L
M
K
T
L
-
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
------
G
G
K
-----------------
V
L
-
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
---
S
E
S
L
-----
M
C
K
I
A
D
F
G
L
A
R
---
V
-
I
------------
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
-
T
-
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
--------
495
Blastp_CBE
55.91
42%
19
- C2 -
-
3LCT
3
A:
[45-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
P
R
K
N
I
-
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----
S
----
G
-------
M
P
-
N
DPSPLQ
V
A
V
K
T
L
P
E
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
-
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-
T
R
PRPSQP
S
-
S
-----------------
L
A
-
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
G
Y
Y
--
R
-
K
G
-
G
C
-
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
-
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
--------------
282
Blastp_CBE
55.99
47%
-12
- C2 -
-
5H2U
4
PTK6_HUMAN
B:
[6-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
F
-
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
----
K
----
D
-------
R
V
-
Q
------
V
A
I
K
V
I
S
R
D
---
N
L
L
H
Q
Q
-
M
L
Q
S
E
I
Q
A
M
K
K
L
-
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
-
D
P
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
--
S
D
------
E
-
K
V----------------
L
P
-
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
---
G
E
N
T
-----
L
C
K
V
G
D
F
G
L
A
R
---
L
-
I
K
E
D
V
Y
--
L
-
S
H
-
D
--
H
N
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
-
S
-
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
-------
379
Blastp_CBE
55.91
46%
-27
- C2 -
-
3DQW
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
D
N
E
T
--
A
-
R
Q
-
G
A
-
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
116
Blastp_CBE
55.95
45%
-18
- C2 -
-
2GQG
2
ABL1_HUMAN
B:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
T
--
A
-
H
A
-
G
A
-
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
196
Blastp_CBE
55.91
42%
-14
- C2 -
-
4EBV
3
A:
[35-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
L
------------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
508
Blastp_CBE
55.81
42%
-3
- C2 -
-
4CD0
1
A:
[42-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
P
R
K
N
I
-
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
---------------------SPLQ--
V
A
V
K
T
L
P
E
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
-
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-
T
R
PRPSQP
S
-
S
-----------------
L
A
-
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
---------
G
-
G
C
-
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
-
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
--------------
313
Blastp_CBE
55.84
46%
-11
- C2 -
-
3UQF
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
-----------
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
378
Blastp_CBE
55.88
46%
-26
- C2 -
-
3DQW
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
D
N
E
T
--
A
-
R
Q
-
G
A
-
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
190
Blastp_CBE
55.84
42%
-7
- C2 -
-
4KAO
1
FAK1_HUMAN
A:
[10-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MS-------
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
--------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
352
Blastp_CBE
55.86
46%
-18
- C2 -
-
3TZ7
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
341
Blastp_CBE
55.85
47%
-7
- C2 -
-
5D7V
3
PTK6_HUMAN
B:
[6-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
F
-
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
----
K
----
D
-------
R
V
-
Q
------
V
A
I
K
V
I
S
R
D
---
N
L
L
H
Q
Q
-
M
L
Q
S
E
I
Q
A
M
K
K
L
-
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
-
D
P
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
-
S
D
------
E
-
K
V----------------
L
P
-
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
---
G
E
N
T
-----
L
C
K
V
G
D
F
G
L
A
R
---
L
-
I
K
E
D
V
Y
--
L
-
S
H
-
D
--
H
N
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
-
S
-
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
-------
24
Blastp_CBE
55.84
45%
-2
- C2 -
-
3CS9
1
ABL1_HUMAN
C:
[9-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
-------
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
52
Blastp_CBE
55.82
45%
4
- C2 -
-
4YC8
3
ABL1_HUMAN
B:
[8-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
------
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
337
Blastp_CBE
55.81
46%
-20
- C2 -
-
3SVV
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
--
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
C
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
--------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
108
Blastp_CBE
55.79
45%
-26
- C2 -
-
2V7A
1
ABL1_HUMAN
B:
[8-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
T
--
A
-
H
A
-
G
A
-
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
299
Blastp_CBE
55.76
46%
-14
- C2 -
-
4YBJ
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
---------
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
275
Blastp_CBE
55.75
46%
-14
- C2 -
-
3U51
1
B:
[3-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
496
Blastp_CBE
55.65
42%
19
- C2 -
-
3LCS
3
A:
[45-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
P
R
K
N
I
-
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----
S
----
G
-------
M
P
-
N
DPSPLQ
V
A
V
K
T
L
P
E
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
-
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-
T
R
PRPSQP
S
-
S
-----------------
L
A
-
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
G
Y
Y
--
R
-
K
G
-
G
C
-
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
-
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
--------------
308
Blastp_CBE
55.73
46%
-12
- C2 -
-
4DGG
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
93
Blastp_CBE
55.71
45%
2
- C2 -
-
2HZN
1
ABL1_MOUSE
A:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
---
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
--
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
309
Blastp_CBE
55.70
46%
-13
- C2 -
-
4AGW
2
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
66
Blastp_CBE
55.68
45%
-10
- C2 -
-
6NPE
3
ABL1_HUMAN
B:
[19-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
--------
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
351
Blastp_CBE
55.67
46%
-18
- C2 -
-
3TZ7
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
310
Blastp_CBE
55.65
46%
-11
- C2 -
-
4AGW
3
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
285
Blastp_CBE
55.59
46%
-13
- C2 -
-
3QLG
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
I
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
32
Blastp_CBE
55.59
45%
3
- C2 -
-
2HZ4
1
ABL1_HUMAN
B:
[6-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
-----
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
25
Blastp_CBE
55.59
45%
-2
- C2 -
-
3CS9
1
ABL1_HUMAN
B:
[10-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
---
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
295
Blastp_CBE
55.58
46%
-13
- C2 -
-
5K9I
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
339
Blastp_CBE
55.57
47%
-7
- C2 -
-
5D7V
3
PTK6_HUMAN
D:
[6-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
F
-
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
----
K
----
D
-------
R
V
-
Q
------
V
A
I
K
V
I
S
R
D
---
N
L
L
H
Q
Q
-
M
L
Q
S
E
I
Q
A
M
K
K
L
-
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
-
D
P
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
-
S
D
------
E
-
K
V----------------
L
P
-
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
---
G
E
N
T
-----
L
C
K
V
G
D
F
G
L
A
R
---
L
-
I
K
E
D
V
Y
--
L
-
S
H
-
D
--
H
N
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
-
S
-
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
-------
510
Blastp_CBE
55.54
42%
-6
- C2 -
-
4FOB
1
A:
[54-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
P
R
K
N
I
-
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----
S
----------------SPLQ--
V
A
V
K
T
L
P
E
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
-
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-
T
R
PRP---
S
-
S
-----------------
L
A
-
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
----------
G
C
-
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
-
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
--------------
381
Blastp_CBE
55.51
47%
-50
- C2 -
-
4LGG
1
SRC_CHICK
A:
[10-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
--
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
-------
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
435
Blastp_CBE
55.48
44%
18
- C2 -
-
5NKF
1
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
--------
S
-
G
KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
--
T
-
T
S
-
G
G
-
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
45
Blastp_CBE
55.47
45%
-10
- C2 -
-
2HZ0
1
ABL1_HUMAN
B:
[3-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
------
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
------
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
--------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
458
Blastp_CBE
55.37
44%
-6
- C2 -
-
5IA0
10
EPHA2_HUMAN
B:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-------
S
---KEVP--
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VL---------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
192
Blastp_CBE
55.43
42%
2
- C2 -
-
4GU6
1
FAK1_HUMAN
A:
[10-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MS--
N
----
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
R
---
Y
-
M
E
D
S
T
Y
--
Y
-
K
A
-
S
K
-
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
334
Blastp_CBE
55.40
47%
-7
- C2 -
-
5DA3
3
PTK6_HUMAN
A:
[6-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
F
-
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
----
K
----
D
-------
R
V
-
Q
------
V
A
I
K
V
I
S
R
D
---
N
L
L
H
-
Q
-
M
L
Q
S
E
I
Q
A
M
K
K
L
-
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
-
D
P
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
-
S
D
------
E
-
K
V----------------
L
P
-
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
---
G
E
N
T
-----
L
C
K
V
G
D
F
G
L
A
R
---
L
-
I
K
E
D
V
Y
--
L
-
S
H
-
D
--
H
N
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
-
S
-
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
-------
376
Blastp_CBE
55.38
46%
-28
- C2 -
-
3DQW
1
SRC_CHICK
D:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
D
N
E
T
--
A
-
R
Q
-
G
A
-
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
260
Blastp_CBE
55.37
46%
-16
- C2 -
-
6ATE
1
SRC_HUMAN
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
----------
P
E
A
F
---
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
T
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
509
Blastp_CBE
55.35
42%
-10
- C2 -
-
4FOC
1
A:
[54-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
P
R
K
N
I
-
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----
S
----------------SPLQ--
V
A
V
K
T
L
P
E
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
-
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-
T
R
PRPSQP
S
-
S
-----------------
L
A
-
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
------------
C
-
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
-
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
--------------
315
Blastp_CBE
55.32
46%
-10
- C2 -
-
3G6G
2
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
-----------------------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
346
Blastp_CBE
55.27
46%
-9
- C2 -
-
1YOM
1
SRC_HUMAN
A:
[10-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
-
E
T
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
186
Blastp_CBE
55.26
42%
-8
- C2 -
-
4I4F
2
A:
[12-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MS-------
P
-------
A
L
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
Y
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
-----------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
281
Blastp_CBE
55.21
47%
-8
- C2 -
-
5H2U
4
PTK6_HUMAN
C:
[6-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
F
-
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
----
K
----
D
-------
R
V
-
Q
------
V
A
I
K
V
I
S
R
D
---
N
L
L
H
Q
Q
-
M
L
Q
S
E
I
Q
A
M
K
K
L
-
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
-
D
P
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
--
S
D
------
E
-
K
V----------------
L
P
-
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
---
G
E
N
T
-----
L
C
K
V
G
D
F
G
L
A
R
---
L
-
I
K
E
D
V
Y
--
L
-
S
H
-
D
--
H
N
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
-
S
-
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
-------
342
Blastp_CBE
55.24
47%
-5
- C2 -
-
5D7V
3
PTK6_HUMAN
A:
[6-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
F
-
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
----
K
----
D
-------
R
V
-
Q
------
V
A
I
K
V
I
S
R
D
---
N
L
L
H
Q
Q
-
M
L
Q
S
E
I
Q
A
M
K
K
L
-
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
-
D
P
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
-
S
D
------
E
-
K
V----------------
L
P
-
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
---
G
E
N
T
-----
L
C
K
V
G
D
F
G
L
A
R
---
L
-
I
K
E
D
V
Y
--
L
-
S
H
-
D
--
H
N
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
-
S
-
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
-------
283
Blastp_CBE
55.22
47%
-11
- C2 -
-
5H2U
4
PTK6_HUMAN
A:
[6-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
F
-
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
----
K
----
D
-------
R
V
-
Q
------
V
A
I
K
V
I
S
R
D
---
N
L
L
H
Q
Q
-
M
L
Q
S
E
I
Q
A
M
K
K
L
-
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
-
D
P
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
--
S
D
------
E
-
K
V----------------
L
P
-
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
---
G
E
N
T
-----
L
C
K
V
G
D
F
G
L
A
R
---
L
-
I
K
E
D
V
Y
--
L
-
S
H
-
D
--
H
N
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
-
S
-
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
-------
276
Blastp_CBE
55.21
46%
-15
- C2 -
-
3U51
1
SRC_CHICK
A:
[3-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
462
Blastp_CBE
55.20
44%
-4
- C2 -
-
5I9X
5
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-----------EVP---
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
--------
G
-
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
328
Blastp_CBE
55.09
46%
-13
- C2 -
-
3EL7
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
--
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
----
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
456
Blastp_CBE
55.01
44%
-16
- C2 -
-
5IA1
2
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
---------------------KEVP--
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
469
Blastp_CBE
55.00
44%
-8
- C2 -
-
1MQB
1
B:
[50-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-----------KEVP--
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VL-------------------
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
271
Blastp_CBE
54.99
46%
-5
- C2 -
-
1YOL
1
SRC_HUMAN
B:
[10-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
-
E
T
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
-----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
345
Blastp_CBE
54.96
46%
-12
- C2 -
-
1YOM
1
SRC_HUMAN
B:
[10-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
-
E
T
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
---------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
428
Blastp_CBE
54.94
44%
13
- C2 -
-
6FNH
6
EPHA2_HUMAN
B:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-------
S
---KEVP--
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
------------
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
455
Blastp_CBE
54.90
44%
15
- C2 -
-
5IA2
3
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-----------KEVP--
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
--
T
-
T
S
-
G
G
-
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
446
Blastp_CBE
54.80
44%
15
- C2 -
-
5NK4
2
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
---------------------KEVP--
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
--
T
-
T
S
-
G
G
-
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
370
Blastp_CBE
54.87
46%
-15
- C2 -
-
5TEH
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
452
Blastp_CBE
54.78
44%
13
- C2 -
-
5IA5
2
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-------
S
---KEVP--
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
--
T
-
T
S
-
G
G
-
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
118
Blastp_CBE
54.80
46%
-28
- C2 -
-
3DK7
1
ABL1_MOUSE
B:
[5-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
------
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
T
--
A
-
H
A
-
G
A
-
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
117
Blastp_CBE
54.79
45%
-18
- C2 -
-
2GQG
2
ABL1_HUMAN
A:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------
N
--------------------------
Y
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
T
--
A
-
H
A
-
G
A
-
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
64
Blastp_CBE
54.78
45%
-7
- C2 -
-
6NPU
5
ABL1_HUMAN
B:
[19-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
--------
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
-----------------------
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
527
Blastp_CBE
54.66
42%
-5
- C2 -
-
3AOX
5
A:
[44-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
P
R
K
N
I
-
T
-
L
I
R
G
L
G
----
G
E
V
Y
E
G
Q
V
---------------------SPLQ--
V
A
V
K
T
L
P
E
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
-
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-
T
R
PRPSQP
S
-
S
-----------------
L
A
-
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
-----------
C
-
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
-
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
--------------
109
Blastp_CBE
54.72
45%
-20
- C2 -
-
2V7A
1
ABL1_HUMAN
A:
[7-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
E
D
T
--
M
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
T
--
A
-
H
A
-
G
A
-
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
115
Blastp_CBE
54.65
46%
-25
- C2 -
-
3DK6
1
ABL1_MOUSE
A:
[5-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
--
G
Q
F
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
-------
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
T
--
A
-
H
A
-
G
A
-
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
272
Blastp_CBE
54.66
46%
-5
- C2 -
-
1YOL
1
SRC_HUMAN
A:
[10-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
-
E
T
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
-----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
62
Blastp_CBE
54.65
45%
-5
- C2 -
-
6NPV
5
ABL1_HUMAN
B:
[19-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
--------
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
-----------------------
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
119
Blastp_CBE
54.63
46%
-23
- C2 -
-
3DK7
1
ABL1_MOUSE
A:
[5-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
K
------
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
T
--
A
-
H
A
-
G
A
-
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
252
Blastp_CBE
54.60
46%
-18
- C2 -
-
5D10
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
----
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A-----
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
-----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
296
Blastp_CBE
54.53
46%
-11
- C2 -
-
5J5S
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
--
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
552
Fugue
54.51
44%
-3
- C2 -
-
1BYG
1
CSK_HUMAN
A:
[15-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
-------------------
A
L
-------
N
M
K
E
L
-
K
-
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
RG----------------
N
-
K
------
V
A
V
K
C
I
K
------
N
D
A
Q
A
-
F
L
A
-
E
A
S
V
M
T
Q
L
-
R
H
S
N
L
V
Q
L
L
G
V
I
V
--E
E
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
-
R
G
R-----
S
-
V
-----------------
L
G
-
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
---
S
E
D
N
-----
V
A
K
V
S
D
F
G
-------------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
-
P
L-
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
521
Blastp_CBE
54.41
42%
-26
- C2 -
-
5IUH
1
A:
[28-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
P
R
K
N
I
-
T
-
L
I
R
G
L
-----
G
E
V
Y
E
G
Q
V
----
S
----
G
-----------PLQ---
V
A
V
K
T
L
P
E
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
-
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-
T
R
PRP---
S
-
S
-----------------
L
A
-
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
--------------------
C
-
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
-
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
--------------
520
Blastp_CBE
54.37
42%
15
- C2 -
-
5IUI
1
A:
[28-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
P
R
K
N
I
-
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----
S
----
G
-----------PSPLQ-
V
A
V
K
T
L
P
E
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
-
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-
T
R
PRPSQP
S
-
S
-----------------
L
A
-
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
A
--------
G
-
G
C
-
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
-
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
--------------
464
Blastp_CBE
54.37
44%
12
- C2 -
-
5I9V
1
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-------
S
S
-
G
KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VL-------------------
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
504
Blastp_CBE
54.45
42%
4
- C2 -
-
2YFX
1
A:
[27-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
P
R
K
N
I
-
T
-
L
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
Q
V
---------------------PLQ---
V
A
V
K
T
L
P
E
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
-
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-
T
R
PRPSQP
S
-
S
-----------------
L
A
-
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
R
---------
G
-
G
C
-
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
-
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
--------------
247
Blastp_CBE
54.43
46%
-25
- C2 -
-
5D12
1
SRC_CHICK
B:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
-----------
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
377
Blastp_CBE
54.42
46%
-27
- C2 -
-
3DQW
1
SRC_CHICK
C:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
D
N
E
T
--
A
-
R
Q
-
G
A
-
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
420
Blastp_CBE
54.41
44%
-13
- C2 -
-
6HEY
1
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-------
S
---EVP---
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
----------------------
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
453
Blastp_CBE
54.37
44%
21
- C2 -
-
5IA4
1
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----------------KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
--
T
-
T
S
-
G
G
-
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
371
Blastp_CBE
54.35
46%
-15
- C2 -
-
5TEH
1
SRC_CHICK
A:
[13-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
-------
P
R
E
S
L
-
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
436
Blastp_CBE
54.34
44%
24
- C2 -
-
5NKE
1
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-------
S
S
-
G
KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
--
T
-
T
S
-
G
G
-
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
463
Blastp_CBE
54.30
44%
-17
- C2 -
-
5I9W
3
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
---------------------KEVP--
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
-------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
460
Blastp_CBE
54.28
44%
-3
- C2 -
-
5I9Z
1
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
--
G
E
V
Y
K
G
M
L
----
K
----
T
-----------KEVP--
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VL---------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
280
Blastp_CBE
54.19
47%
-8
- C2 -
-
5H2U
4
PTK6_HUMAN
D:
[6-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
F
-
T
-
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
----
K
----
D
-------
R
V
-
Q
------
V
A
I
K
V
I
S
R
D
---
N
L
L
H
Q
Q
-
M
L
Q
S
E
I
Q
A
M
K
K
L
-
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
G
-
D
P
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
--
S
D
------
E
-
K
V----------------
L
P
-
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
---
G
E
N
T
-----
L
C
K
V
G
D
F
G
L
A
R
---
L
-
I
K
E
D
V
Y
--
L
-
S
H
-
D
--
H
N
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
-
S
-
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
-------
505
Blastp_CBE
54.10
42%
8
- C2 -
-
4ANS
1
A:
[42-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
P
R
K
N
I
-
T
-
L
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
Q
V
---------------------PLQ---
V
A
V
K
T
L
P
E
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
-
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-
T
R
PRPSQP
S
-
S
-----------------
L
A
-
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
-----
V
A
K
I
A
D
F
G
M
A
R
---
D
I
Y
R
---------
G
-
G
C
-
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
-
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
--------------
499
Blastp_CBE
54.01
44%
-17
- C2 -
-
3DKO
1
A:
[50-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
G
A
-
E
F
G
E
V
C
S
G
R
L
----
K
LPGK
R
-------
D
V
-
A
------
V
A
I
K
T
L
K
V
G
Y
T
-
E
K
Q
R
R
D
-
F
L
C
-
E
A
S
I
M
G
Q
F
-
D
H
P
N
V
V
H
L
E
G
V
V
T
R
G
-
K
P
V
M
I
V
I
E
F
M
E
N
G
A
L
D
A
F
L
R
K
-
H
D
------
G
-
Q
-----------------
F
T
-
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
R
Y
L
A
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
---------------------------
P
V
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
-
S
-
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
A
P
M
D
C
P
A
G
L
H
Q
L
M
L
D
C
W
Q
K
E
R
A
E
R
P
K
F
E
Q
I
------------
416
Blastp_CBE
54.00
44%
-14
- C2 -
-
6Q7E
1
?
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-----------EVP---
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
--------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
68
Blastp_CBE
53.99
45%
-6
- C2 -
-
3PYY
3
ABL1_HUMAN
B:
[19-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
--------
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
-----------------------
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
429
Blastp_CBE
53.87
44%
20
- C2 -
-
6FNH
11
EPHA2_HUMAN
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
--------
S
-
G
KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
---------------
G
-
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
439
Blastp_CBE
53.85
44%
8
- C2 -
-
5NKB
3
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
---------------------KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
--
T
-
T
---
G
-
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
459
Blastp_CBE
53.82
44%
-6
- C2 -
-
5IA0
7
EPHA2_HUMAN
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-----------KEVP--
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
--------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
441
Blastp_CBE
53.78
44%
13
- C2 -
-
5NK9
1
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
---------------------KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
--
T
-
T
---
G
-
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
451
Blastp_CBE
53.72
44%
8
- C2 -
-
5NJZ
1
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-----------KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
425
Blastp_CBE
53.67
44%
-15
- C2 -
-
6HET
1
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-----------EVP---
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
--------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
414
Blastp_CBE
53.66
44%
-12
- C2 -
-
6Q7G
1
?
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-----------KEVP--
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
--------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
448
Blastp_CBE
53.62
44%
17
- C2 -
-
5NK2
2
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
---------------------KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
--------
G
-
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
419
Blastp_CBE
53.53
44%
-9
- C2 -
-
6Q7B
1
?
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-----------KEVP--
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
--------------------
G
-
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
431
Blastp_CBE
53.60
44%
-10
- C2 -
-
6FNF
1
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-----------KEVP--
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
445
Blastp_CBE
53.54
44%
18
- C2 -
-
5NK5
1
A:
[23-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
---
F
G
E
V
Y
K
G
M
L
----
K
----
T
-------
S
S
-
G
KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
--
T
-
T
--
G
G
-
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
418
Blastp_CBE
53.53
44%
-15
- C2 -
-
6Q7C
1
?
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
--
F
G
E
V
Y
K
G
M
L
----
K
----
T
-----------KEVP--
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
--------------------
G
-
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
437
Blastp_CBE
53.52
44%
14
- C2 -
-
5NKD
2
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
---------------------KEVP--
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
--------
G
-
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
417
Blastp_CBE
53.51
44%
-10
- C2 -
-
6Q7D
1
?
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-----------KEVP--
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
-------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
405
Blastp_CBE
53.50
44%
0
- C2 -
-
3A4O
1
LYN_HUMAN
X:
[6-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D----
A
W
-------------------
E
I
-------
P
R
E
S
I
-
K
-
L
V
K
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
----
N
----
N
-------
S
T
-
K
------
V
A
V
K
T
L
K
---
P
-
G
T
M
S
V
Q
A
F
L
E
-
E
A
N
L
M
K
T
L
-
Q
H
D
K
L
V
R
L
Y
A
V
V
T
R
E
-
E
P
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
---
K
S
------
D
-
E
GGK--------------
V
L
-
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
---
S
E
S
L
-----
M
C
K
I
A
D
F
G
L
A
R
---
V
--------------
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
-
T
-
N
A
D
V
M
T
A
L
S
Q
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
--------
203
Blastp_CBE
53.47
42%
-8
- C2 -
-
2J0L
1
A:
[7-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
Q
R
E
R
I
-
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
MSPE
N
----
P
-------
A
M
-
A
------
V
A
I
K
T
C
K
N
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
-
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
K
------
F
-
S
-----------------
L
D
-
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
R
---
Y
-
M
E
D
S
T
K
--
A
-
S
K
-
G
---
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
-
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
-----
454
Blastp_CBE
53.41
44%
5
- C2 -
-
5IA3
1
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----------------KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
-----------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
461
Blastp_CBE
53.32
44%
17
- C2 -
-
5I9Y
4
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-----------KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
-------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
443
Blastp_CBE
53.32
44%
13
- C2 -
-
5NK7
1
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
---------------------KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
--------
G
-
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
114
Blastp_CBE
53.37
46%
-24
- C2 -
-
3DK6
1
ABL1_MOUSE
B:
[5-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
-------
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
K
T
L
-------
E
V
E
-
E
-
F
L
K
-
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
S
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
T
--
A
-
H
A
-
G
A
-
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
424
Blastp_CBE
53.32
44%
-11
- C2 -
-
6HEU
1
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-----------KEVP--
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
449
Blastp_CBE
53.26
44%
15
- C2 -
-
5NK1
1
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
---------------------KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
--------
G
-
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
444
Blastp_CBE
53.14
44%
18
- C2 -
-
5NK6
1
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
---------------------KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
-------
G
G
-
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
380
Blastp_CBE
53.10
47%
-3
- C2 -
-
4LGG
1
B:
[6-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
----
N
----
G
-------
T
T
-
R
------
V
A
I
K
T
L
K
---
P
-
G
T
M
S
P
E
A
F
L
Q
-
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
E
--
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
M
------
G
-
K
Y----------------
L
R
-
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
---
G
E
N
L
-----
V
C
K
V
A
D
----------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
-
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
--------
415
Blastp_CBE
53.05
44%
-12
- C2 -
-
6Q7F
1
?
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-----------EVP---
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
---------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
450
Blastp_CBE
52.95
44%
14
- C2 -
-
5NK0
1
A:
[23-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-------
S
S
-
G
KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
--------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
447
Blastp_CBE
52.89
44%
9
- C2 -
-
5NK3
2
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-----------KEVP--
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
--
T
-----
G
-
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
427
Blastp_CBE
52.82
44%
14
- C2 -
-
6FNH
5
C:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
----------
G
KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
--------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
438
Blastp_CBE
52.70
44%
19
- C2 -
-
5NKC
2
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
---------------------KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
----------
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
525
Blastp_CBE
52.66
42%
-2
- C2 -
-
4DCE
1
B:
[34-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
P
R
K
N
I
-
T
-
L
I
R
G
L
G
H
----
E
V
Y
E
G
Q
V
----
S
----------------SPLQ--
V
A
V
K
T
L
P
E
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
-
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-
T
R
PRPSQP
S
-
S
-----------------
L
A
-
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
-----
V
A
K
I
G
D
F
----------------------
G
C
-
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
-
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
--------------
523
Blastp_CBE
52.62
42%
-1
- C2 -
-
4FNZ
1
A:
[28-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
P
R
K
N
I
-
T
-
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
----
S
----
G
-----------SPLQ--
V
A
V
K
T
L
P
E
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
-
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-
T
R
PRPSQP
S
-
S
-----------------
L
A
-
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
-----
V
A
K
I
G
D
F
----------------------
G
C
-
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
-
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
--------------
522
Blastp_CBE
52.41
42%
-1
- C2 -
-
5IUG
1
A:
[28-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
P
R
K
N
I
-
T
-
L
I
R
G
L
G
----
G
E
V
Y
E
G
Q
V
---------------------SPLQ--
V
A
V
K
T
L
P
E
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
-
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-
T
R
PRP-----
S
-----------------
L
A
-
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
-------------------
G
C
-
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
-
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
--------------
423
Blastp_CBE
52.30
44%
9
- C2 -
-
6HEV
1
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
---------------------KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
470
Blastp_CBE
52.06
44%
15
- C2 -
-
1MQB
1
EPHA2_HUMAN
A:
[50-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-----------KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
-----------------------
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
442
Blastp_CBE
51.92
44%
16
- C2 -
-
5NK8
1
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
----
G
E
V
Y
K
G
M
L
----
K
----
T
-------
S
S
-
G
KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
---------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
440
Blastp_CBE
51.79
44%
18
- C2 -
-
5NKA
2
A:
[23-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
-------
S
S
-
G
KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
-----------------------
G
-
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
432
Blastp_CBE
51.79
44%
10
- C2 -
-
5NKI
1
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
---------------------KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
---------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
421
Blastp_CBE
51.62
44%
12
- C2 -
-
6HEX
1
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
---------------------KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
--------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
71
Blastp_CBE
51.57
45%
11
- C2 -
-
4WA9
1
ABL1_HUMAN
A:
[10-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
-------
E
R
T
D
I
-
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----
K
----
K
-------
Y
S
L
T
------
V
A
V
-------------------------
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
---
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
------
Q
-
E
-----------------
V
N
-
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
--
T
-
A
H
-
A
G
-
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
-
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
--------
426
Blastp_CBE
51.43
44%
13
- C2 -
-
6HES
1
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
---------------------KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
422
Blastp_CBE
51.31
44%
18
- C2 -
-
6HEW
1
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
---------------------KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
--------------------
G
-
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
526
Blastp_CBE
51.19
42%
23
- C2 -
-
4DCE
1
ALK_HUMAN
A:
[34-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
P
R
K
N
I
-
T
-
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
----
S
----------------PSPLQ-
V
A
V
K
T
L
P
E
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
-
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-
T
R
PRPSQP
S
-
S
-----------------
L
A
-
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
-----
V
A
K
I
G
D
F
--------------------
G
-
G
C
-
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
-
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
--------------
457
Blastp_CBE
51.18
44%
18
- C2 -
-
5IA0
6
C:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
----
K
----
T
----------
G
KKEVP-
V
A
I
K
T
L
K
A
--
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
430
Blastp_CBE
51.17
44%
17
- C2 -
-
6FNG
6
A:
[23-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
---------------------KKEVP-
V
A
I
K
T
L
K
A
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
-
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
D
------
G
-
E
-----------------
F
S
-
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
-----------------------
K
-
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
-
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
------------
494
Blastp_CBE
50.38
42%
-23
- C2 -
-
4JOA
1
A:
[45-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
P
R
K
N
I
-
T
-
L
I
R
G
L
G
------
V
Y
E
G
Q
V
----
S
----------------LQ----
V
A
V
K
T
L
P
----------
D
-
F
L
M
-
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-
T
R
PR------------------------
L
A
-
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
I
Y
---------------
A
M
L
P
V
K
W
M
P
P
E
A
---
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
-
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
--------------
383
Blastp_CBE
45.65
44%
8
- C2 -
-
5MJA
1
EPHB1_HUMAN
A:
[32-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
I
G
A
G
E
F
G
E
V
Y
K
G
R
L
----
K
LPG-
K
-------
R
E
-
I
------
V
A
I
K
T
L
K
A
G
Y
S
-
E
K
Q
R
R
D
-
F
L
S
-
E
A
S
I
M
G
Q
F
-
D
H
R
N
I
I
R
L
E
G
V
V
T
K
S
-
R
P
V
M
I
I
T
E
F
M
E
N
G
A
L
D
S
F
L
R
Q
-
N
D
------
G
-
Q
-----------------
F
T
-
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
S
E
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
YL-
Q
-
D
D
T
S
D
P
--------------
V
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
-
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
A
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
S
R
P
R
F
A
E
I
V
N
T
L
--------
382
Blastp_CBE
45.37
44%
6
- C2 -
-
5MJA
1
B:
[32-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
I
G
A
G
E
F
G
E
V
Y
K
G
R
L
----
K
LPG-
K
-------
R
E
-
I
------
V
A
I
K
T
L
K
A
G
Y
S
-
E
K
Q
R
R
D
-
F
L
S
-
E
A
S
I
M
G
Q
F
-
D
H
R
N
I
I
R
L
E
G
V
V
T
K
S
-
R
P
V
M
I
I
T
E
F
M
E
N
G
A
L
D
S
F
L
R
Q
-
N
D
------
G
-
Q
-----------------
F
T
-
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
S
E
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
YL-
Q
---------
T
-
T
S
-
S
L
G
G
K
I
P
V
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
-
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
A
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
S
R
P
R
F
A
E
I
V
N
T
L
--------
404
Blastp_CBE
45.09
44%
8
- C2 -
-
5MJB
1
EPHB1_HUMAN
A:
[32-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
I
G
A
G
E
F
G
E
V
Y
K
G
R
L
----
K
LPG-
K
-------
R
E
-
I
------
V
A
I
K
T
L
K
A
G
Y
S
-
E
K
Q
R
R
D
-
F
L
S
-
E
A
S
I
M
G
Q
F
-
D
H
R
N
I
I
R
L
E
G
V
V
T
K
S
-
R
P
V
M
I
I
T
E
F
M
E
N
C
A
L
D
S
F
L
R
Q
-
N
D
------
G
-
Q
-----------------
F
T
-
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
S
E
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
---
N
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
YL-
Q
---------
T
-
T
S
-
S
L
G
G
K
I
P
V
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
-
S
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
A
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
S
R
P
R
F
A
E
I
V
N
T
L
--------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------