@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : FES_HUMAN: (2020-09-09 )
MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSRAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQWQQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR
Atome Classification :
(420 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440........450----.----.----------.....460.......470..--.----.----.----.---.----480.....-.-.490....-----..-----.-----500.------.......-510-...-.-.-.-..520......----------.-------530.-......540-------.-----.---------.---------.------..---.-.----------------------550--------------------.-...-------------------.....560-------.-.......570......-.------580----.-----.--.----.---....590..-...-..600.-......610.......620.....-..-630.......640.......------650---.------.-.-..--.---------..--.--660.......670.......680.......690---...-----....700....---.-..710.-.-.....720.......730.......740.......750.......760...-....770.......780.......790.......800.....----..810.......820
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGFSSELCSPQG
H
G
V
L
Q
Q
M
Q
E
A
E
L
R
L
L
E
G
M
R
K
W
M
A
Q
R
V
KSD
R
E
Y
A
G
L
L
H
HMSLQDSGGQSRAISPDSP
I
S
Q
S
W
A
E
I
T
S
Q
T
E
G
L
S
R
L
L
R
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H
A
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DLNSG
P
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Y
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Y
Q
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ASKDK
D
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A
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D
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Y
V
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S
L
W
K
L
F
AHHN
R
Y
V
L
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R
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A
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A
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ARIQ
P
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Y
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QYGSAPDVPPCVTF
D
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LEEGEPLEPGEL
Q
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N
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RNEEENT
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HLGPGEPP
P
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QDDRHSTSS
S
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REGGRT
P
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IFRPKFS-LP
P
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R-L-E-G-EGFPS
I
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L
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LST-QQPLTKKS--------
G
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------
H
R---A-V----------------------P----------------------K-D
K
W
-------------------
V
LNH
E
D
L
--------
V
-
L
G
E
QIGRGN
F
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FSG-R------LR-----A-----D--
N
----
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---
L
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C
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VT---EK
N
-----
V
L
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SDFGMSR---E-EAD
G
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P
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WTAPEALNYGRYSSES
D
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TFSLGASPYPNLS-
N
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KGGRLP
C
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EL
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WAYEPGQRP
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----
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RHR
540
HHSearch
92.79
100%
-124
- C3 -
-
6JMF
1
A:
[3-374]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
Q
----
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R
H
-
5
PsiBlast_PDB
92.79
100%
-124
- C3 -
-
6JMF
1
A:
[3-374]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
Q
----
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----
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----------
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T
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L
Q
S
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R
H
-
541
HHSearch
92.67
100%
-120
- C3 -
-
3BKB
9
A:
[5-376]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
Q
----
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----
P
----------
L
H
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Q
L
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Y
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T
I
Y
Q
E
L
Q
S
I
R
K
R
H
-
2
PsiBlast_PDB
92.43
99%
-120
- C3 -
-
3BKB
9
A:
[4-376]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
Q
----
K
----
P
----------
L
H
E
Q
L
W
Y
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G
A
I
P
R
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A
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----
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---
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M
E
L
V
Q
G
G
D
F
L
T
F
L
R
------
T
-----
E
------
G
-
A
-
R
L
--
R
---------
V
K
--
T
--
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
K
N
-----
V
L
K
I
S
D
F
G
M
S
R
---
E
-
E
A
D
G
V
Y
-
A
-
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
----
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
-
3
PsiBlast_PDB
88.77
99%
-131
- C3 -
-
3CBL
3
A:
[2-376]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
P
E
V
Q
----
K
----
P
----------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
--
V
----
H
----
S
----
G
---
D
----
F
L
V
R
E
S
Q
----
Q
E
Y
V
L
S
V
--------------------
P
-
R
------
H
F
I
I
-----
N
--
L
Y
R
-
L
-------
F
P
S
I
P
L
L
I
D
----------
H
-------
L
L
S
T
-
Q
Q
P
L
------------------
V
---------
V
---------
L
------
H
R
---
A
-
V
----------------------
P
----------------------
K
-
D
K
W
-------------------
V
L
N
H
E
D
L
--------
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
-
R
------
L
R
-----
A
-----
D
--
N
----
T
---
L
V
A
V
K
S
C
R
E
-
T
L
P
-
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
K
-
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
------
T
-----
E
------
G
-
A
-
R
L
--
R
---------
V
K
--
T
--
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
K
N
-----
V
L
K
I
S
D
F
G
M
S
R
---
E
-
E
A
D
G
V
Y
-
A
-
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
----
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
-
4
PsiBlast_PDB
88.50
99%
-120
- C3 -
-
4E93
1
A:
[2-377]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
P
E
V
Q
----
K
----
P
----------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
--
V
----
H
----
S
----
G
---
D
----
F
L
V
R
E
S
Q
----
Q
E
Y
V
L
S
V
L
-----
W
D
-----
G
-----
L
P
-
R
------
H
F
I
I
Q
S
L
-
D
N
--
L
Y
R
-
L
-
E
-
G
-
E
G
F
P
S
I
P
L
L
I
D
----------
H
-------
L
L
S
T
-
Q
Q
P
L
T
K
K
S
--------
G
-----
V
---------
V
---------
L
------
H
R
---
A
-
V
----------------------
P
----------------------
K
-
D
K
W
-------------------
V
L
N
H
E
D
L
--------
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
-
R
------
L
R
-----
A
-----
D
--
N
----
T
---
L
V
A
V
K
S
C
R
E
-
T
L
P
-
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
K
-
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
------
T
-----
E
------
G
-
A
-
R
L
--
R
---------
V
K
--
T
--
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
K
N
-----
V
L
K
I
S
D
F
G
M
S
R
---
E
-----------------
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
----
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
R
542
HHSearch
88.42
100%
-132
- C3 -
-
3CBL
3
A:
[5-376]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
Q
----
K
----
P
----------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
--
V
----
H
----
S
----
G
---
D
----
F
L
V
R
E
S
Q
----
Q
E
Y
V
L
S
V
--------------------
P
-
R
------
H
F
I
I
-----
N
--
L
Y
R
-
L
-------
F
P
S
I
P
L
L
I
D
----------
H
-------
L
L
S
T
-
Q
Q
P
L
------------------
V
---------
V
---------
L
------
H
R
---
A
-
V
----------------------
P
----------------------
K
-
D
K
W
-------------------
V
L
N
H
E
D
L
--------
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
-
R
------
L
R
-----
A
-----
D
--
N
----
T
---
L
V
A
V
K
S
C
R
E
-
T
L
P
-
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
K
-
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
------
T
-----
E
------
G
-
A
-
R
L
--
R
---------
V
K
--
T
--
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
K
N
-----
V
L
K
I
S
D
F
G
M
S
R
---
E
-
E
A
D
G
V
Y
-
A
-
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
----
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
-
6
PsiBlast_PDB
87.59
99%
-128
- C3 -
-
3CD3
3
A:
[2-376]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
P
E
V
Q
----
K
----
P
----------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
--
V
----
H
----
S
----
G
---
D
----
F
L
V
R
E
S
-----
Q
E
Y
V
L
S
V
--------------------
P
-
R
------
H
F
I
I
-----
N
--
L
Y
R
-
L
-------
F
P
S
I
P
L
L
I
D
----------
H
-------
L
L
S
T
-
Q
Q
P
L
---
S
--------
G
-----
V
---------
V
---------
L
------
H
R
---
A
-
V
----------------------
P
----------------------
K
-
D
K
W
-------------------
V
L
N
H
E
D
L
--------
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
-
R
------
L
R
-----
A
-----
D
--
N
----
T
---
L
V
A
V
K
S
C
R
------
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
K
-
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
------
T
-----
E
------
G
-
A
-
R
L
--
R
---------
V
K
--
T
--
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
K
N
-----
V
L
K
I
S
D
F
G
M
S
R
---
E
-
E
A
D
G
V
Y
-
A
-
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
----
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
-
559
Fugue
80.11
99%
-100
- C3 -
-
3CD3
3
A:
[1-376]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
I
P
E
V
Q
----
K
----
P
----------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
--
V
----
H
----
S
----
G
---
D
----
F
L
V
R
E
S
Q
-----
E
Y
V
L
S
V
--------------------
P
-
R
------
H
F
I
I
-----
N
--
L
Y
R
-
L
-------
F
P
S
I
P
L
L
I
D
----------
H
-------
L
L
S
T
-
Q
Q
P
L
---
S
--------
G
-----
V
---------
V
---------
L
------
H
R
---
A
-
V
----------------------
P
----------------------
K
-
D
K
W
-------------------
V
L
N
H
E
D
L
--------
V
-
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
-
R
------
L
R
-----
A
-----
D
--
N
----
T
---
L
V
A
V
K
S
C
R
------
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
K
-
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
------
T
-----
E
------
G
-
A
-
R
L
--
R
---------
V
K
--
T
--
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
K
N
-----
V
L
K
I
S
D
F
G
M
S
R
---
E
-
E
A
D
G
V
A
-
A
--
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
----
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
-
539
HHSearch
62.53
100%
-203
- C- -
-
4DYL
-
FES_HUMAN
A:
[1-402]
M
G
F
S
S
E
L
C
S
P
Q
G
H
G
V
L
Q
Q
M
Q
E
A
E
L
R
L
L
E
G
M
R
K
W
M
A
Q
R
V
K
S
D
R
E
Y
A
G
L
L
H
H
M
------------
S
P
D
S
P
I
S
Q
S
W
A
E
I
T
S
Q
T
E
G
L
S
R
L
L
R
Q
H
A
E
D
L
N
S
G
P
L
S
K
L
S
L
L
I
R
E
R
Q
Q
L
R
K
T
Y
S
E
Q
W
Q
Q
L
Q
Q
E
L
T
K
T
H
S
Q
D
I
E
K
L
K
S
Q
Y
R
A
L
A
R
D
S
A
Q
A
K
R
K
Y
---------
D
K
A
K
D
K
Y
V
R
S
L
W
K
L
F
A
H
H
N
R
Y
V
L
G
V
R
A
A
Q
L
H
H
Q
H
H
H
Q
L
L
L
P
G
L
L
R
S
L
Q
D
L
H
E
E
M
A
C
I
L
K
E
I
L
Q
E
Y
L
E
I
S
S
L
V
Q
D
E
V
V
A
I
H
R
E
M
A
A
A
A
A
R
I
Q
P
E
A
E
Y
Q
G
F
L
R
Q
Y
G
S
A
P
D
V
P
P
C
V
T
F
D
E
S
L
------
L
E
P
G
E
L
Q
L
N
E
L
T
V
E
S
V
Q
H
T
L
T
S
V
T
D
E
L
A
V
A
T
E
M
V
F
R
R
Q
E
M
V
T
Q
L
Q
Q
E
L
R
N
E
E
E
N
T
H
P
R
E
R
V
Q
L
L
G
K
R
Q
V
L
Q
E
A
L
Q
G
L
Q
V
A
L
C
S
Q
A
K
L
Q
A
Q
Q
E
L
L
Q
T
K
L
E
H
L
G
P
G
E
P
P
P
V
L
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
62.53
100%
-203
- C- -
-
4DYL
-
FES_HUMAN
A:
[1-402]
M
G
F
S
S
E
L
C
S
P
Q
G
H
G
V
L
Q
Q
M
Q
E
A
E
L
R
L
L
E
G
M
R
K
W
M
A
Q
R
V
K
S
D
R
E
Y
A
G
L
L
H
H
M
------------
S
P
D
S
P
I
S
Q
S
W
A
E
I
T
S
Q
T
E
G
L
S
R
L
L
R
Q
H
A
E
D
L
N
S
G
P
L
S
K
L
S
L
L
I
R
E
R
Q
Q
L
R
K
T
Y
S
E
Q
W
Q
Q
L
Q
Q
E
L
T
K
T
H
S
Q
D
I
E
K
L
K
S
Q
Y
R
A
L
A
R
D
S
A
Q
A
K
R
K
Y
---------
D
K
A
K
D
K
Y
V
R
S
L
W
K
L
F
A
H
H
N
R
Y
V
L
G
V
R
A
A
Q
L
H
H
Q
H
H
H
Q
L
L
L
P
G
L
L
R
S
L
Q
D
L
H
E
E
M
A
C
I
L
K
E
I
L
Q
E
Y
L
E
I
S
S
L
V
Q
D
E
V
V
A
I
H
R
E
M
A
A
A
A
A
R
I
Q
P
E
A
E
Y
Q
G
F
L
R
Q
Y
G
S
A
P
D
V
P
P
C
V
T
F
D
E
S
L
------
L
E
P
G
E
L
Q
L
N
E
L
T
V
E
S
V
Q
H
T
L
T
S
V
T
D
E
L
A
V
A
T
E
M
V
F
R
R
Q
E
M
V
T
Q
L
Q
Q
E
L
R
N
E
E
E
N
T
H
P
R
E
R
V
Q
L
L
G
K
R
Q
V
L
Q
E
A
L
Q
G
L
Q
V
A
L
C
S
Q
A
K
L
Q
A
Q
Q
E
L
L
Q
T
K
L
E
H
L
G
P
G
E
P
P
P
V
L
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
549
HHSearch
62.25
36%
-2
- C3 -
-
1K9A
-
CSK_RAT
E:
[19-445]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
H
G
T
A
E
Q
D
L
P
F
C
K
--
G
D
V
L
T
I
V
A
V
T
K
D
P
N
W
Y
K
A
K
N
-
K
V
G
R
E
G
I
I
P
A
N
Y
----
V
----
Q
KREGVKAGTK
L
S
L
M
P
W
F
H
G
K
I
T
R
E
Q
A
E
R
L
L
YP
P
----
E
----
T
----
G
---
L
----
F
L
V
R
E
S
T
N
-
Y
P
G
D
Y
T
L
C
V
S
-----
C
E
-----
G
-----
K
V
-
E
------
H
Y
R
I
M
Y
H
-
A
S
--
K
L
S
-
I
D
E
-
E
-
V
Y
F
E
N
L
M
Q
L
V
E
----------
H
-------
Y
T
T
D
-
A
D
G
L
C
T
R
L
IKPKVMEG
T
-----
V
---------
A
---------
A
------
Q
D
---
E
-
F
----------------------
Y
----------------------
R
-
S
G
W
-------------------
A
L
N
M
K
E
L
--------
K
-
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
-
D
------
Y
R
--------------
G
----
N
---
K
V
A
V
K
C
I
K
N
-
D
----
A
T
A
Q
A
-
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
E
E
K
-
G
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
------
S
-----
R
------
G
-
R
S
V
L
--
G
---------
G
D
--
C
--
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
---
E
D
N
-----
V
A
K
V
S
D
F
G
L
T
K
---
E
-
A
S
S
T
------------
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
-
L
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
D
V
M
K
N
C
W
H
L
D
A
A
T
R
P
T
F
----
L
Q
L
R
E
Q
L
E
H
I
R
T
---
546
HHSearch
62.13
36%
23
- C3 -
-
2H8H
1
SRC_HUMAN
A:
[98-523]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
T
E
G
D
W
W
L
A
H
S
L
-
S
T
G
Q
T
G
Y
I
P
S
N
Y
VAPS
D
----
S
----------
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
--
L
----
N
AENP
R
----
G
---
T
----
F
L
V
R
E
S
E
T
-
T
K
G
A
Y
C
L
S
V
S
-----
D
F
DNAKG
L
-----
N
V
-
K
------
H
Y
K
I
R
K
L
D
S
G
--
G
F
Y
-
I
T
S
-
R
-
T
Q
F
N
S
L
Q
Q
L
V
A
----------
Y
-------
Y
S
K
H
-
A
D
G
L
C
H
R
L
--------
T
-----
T
---------
V
---------
C
PTSKPQ
T
Q
---
G
-
L
----------------------
A
----------------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
-
T
------
W
N
-----
G
-----
T
-------
T
---
R
V
A
I
K
T
L
K
P
-
G
T
---
M
S
P
E
A
-
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
------
G
-----
E
------
T
G
K
-
Y
L
--
R
---------
L
P
--
Q
--
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
D
N
E
Y
-
T
-
A
R
-
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
----
E
Y
L
Q
A
F
L
E
D
Y
F
T
---
544
HHSearch
61.88
36%
-4
- C3 -
-
1K9A
-
CSK_RAT
B:
[19-445]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
H
G
T
A
E
Q
D
L
P
F
C
K
--
G
D
V
L
T
I
V
A
V
T
K
D
P
N
W
Y
K
A
K
N
-
K
V
G
R
E
G
I
I
P
A
N
Y
----
V
----
Q
KREGVKAGTK
L
S
L
M
P
W
F
H
G
K
I
T
R
E
Q
A
E
R
L
L
--
Y
PP--
E
----
T
----
G
---
L
----
F
L
V
R
E
S
T
N
-
Y
P
G
D
Y
T
L
C
V
S
-----
C
E
-----
G
-----
K
V
-
E
------
H
Y
R
I
M
Y
H
-
A
S
--
K
L
S
-
I
D
E
-
E
-
V
Y
F
E
N
L
M
Q
L
V
E
----------
H
-------
Y
T
T
D
-
A
D
G
L
C
T
R
L
IKPKVMEG
T
-----
V
---------
A
---------
A
------
Q
D
---
E
-
F
----------------------
Y
----------------------
R
-
S
G
W
-------------------
A
L
N
M
K
E
L
--------
K
-
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
-
D
------
Y
R
--------------
G
----
N
---
K
V
A
V
K
C
I
K
N
-
D
----
A
T
A
Q
A
-
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
E
E
K
-
G
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
------
S
-----
R
------
G
-
R
S
V
L
--
G
---------
G
D
--
C
--
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
---
E
D
N
-----
V
A
K
V
S
D
F
G
L
T
K
---
E
-
A
-------------
G
K
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
-
L
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
D
V
M
K
N
C
W
H
L
D
A
A
T
R
P
T
F
----
L
Q
L
R
E
Q
L
E
H
I
R
T
---
22
Blastp_CBE
61.34
39%
-10
- C3 -
-
1OPL
1
ABL1_HUMAN
B:
[140-515]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
-
N
A
A
E
Y
L
--
L
----
S
----
S
----
G
ING
S
----
F
L
V
R
E
S
E
S
-
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
-----
G
-----
R
V
-
Y
------
H
Y
R
I
N
T
A
-
S
D
GK
L
Y
V
-
S
-
S
-
E
-
S
R
F
N
T
L
A
E
L
V
H
----------
H
HSTVADG
L
I
T
T
L
H
Y
P
A
P
---------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
11
PsiBlast_PDB
61.13
38%
6
- C3 -
-
1OPL
2
ABL1_HUMAN
A:
[131-515]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
N
Y
I
T
P
V
N
----
S
---------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
-
N
A
A
E
Y
L
--
L
----
S
----
S
----
G
ING
S
----
F
L
V
R
E
S
E
S
-
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
-----
G
-----
R
V
-
Y
------
H
Y
R
I
N
T
A
-
S
D
GK
L
Y
V
-
S
-
S
-
E
-
S
R
F
N
T
L
A
E
L
V
H
----------
H
HSTVADG
L
I
T
T
L
H
Y
P
A
P
K
R
N
--------
K
-----
P
---------
T
---------
V
------
Y
G
---
V
-
S
----------------------
P
----------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
9
PsiBlast_PDB
61.12
38%
4
- C3 -
-
1OPK
3
ABL1_MOUSE
A:
[92-476]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
N
Y
I
T
P
V
N
----
S
---------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
-
N
A
A
E
Y
L
--
L
----
S
----
S
----
G
ING
S
----
F
L
V
R
E
S
E
S
-
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
-----
G
-----
R
V
-
Y
------
H
Y
R
I
N
T
A
-
S
D
GK
L
Y
V
-
S
-
S
-
E
-
S
R
F
N
T
L
A
E
L
V
H
----------
H
HSTVADG
L
I
T
T
L
H
Y
P
A
P
K
R
N
--------
K
-----
P
---------
T
---------
I
------
Y
G
---
V
-
S
----------------------
P
----------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
547
HHSearch
60.85
36%
12
- C3 -
-
1Y57
1
SRC_HUMAN
A:
[17-440]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
T
E
G
D
W
W
L
A
H
S
L
-
S
T
G
Q
T
G
Y
I
P
S
N
Y
----
V
APSD
S
----------
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
--
L
----
N
AENP
R
----
G
---
T
----
F
L
V
R
E
S
E
T
-
T
K
G
A
Y
C
L
S
V
S
-----
D
F
-----
D
NAKGL
N
V
-
K
------
H
Y
K
I
R
K
L
D
S
G
--
G
F
Y
-
I
T
S
-
R
-
T
Q
F
N
S
L
Q
Q
L
V
A
----------
Y
-------
Y
S
K
H
-
A
D
G
L
C
H
R
L
--------
T
-----
T
---------
V
CPTSKP---
Q
------
T
Q
---
G
-
L
----------------------
A
----------------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
-
T
------
W
N
-----
G
-----
T
-------
T
---
R
V
A
I
K
T
L
K
P
-
G
T
---
M
S
P
E
A
-
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
------
G
-----
E
------
T
G
K
-
Y
L
--
R
---------
L
P
--
Q
--
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
D
N
E
Y
-
T
-
A
R
-
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
----
E
Y
L
Q
A
F
L
E
D
Y
F
T
---
10
PsiBlast_PDB
60.18
38%
2
- C3 -
-
2FO0
4
ABL1_HUMAN
A:
[89-473]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
N
Y
I
T
P
V
N
----
S
---------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
-
N
A
A
E
Y
L
--
L
----
S
----
S
----
G
ING
S
----
F
L
V
R
E
S
E
S
-
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
-----
G
-----
R
V
-
Y
------
H
Y
R
I
N
T
A
-
S
D
GK
L
Y
V
-
S
-
S
-
E
-
S
R
F
N
T
L
A
E
L
V
H
----------
H
HSTVADG
L
I
T
T
L
H
Y
P
A
P
K
R
N
--------
K
-----
P
---------
T
---------
V
------
Y
G
---
V
-
S
----------------------
P
----------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
548
HHSearch
59.98
36%
15
- C3 -
-
1FMK
-
SRC_HUMAN
A:
[98-521]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
T
E
G
D
W
W
L
A
H
S
L
-
S
T
G
Q
T
G
Y
I
P
S
N
Y
VAPS
D
----
S
----------
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
--
L
----
N
AENP
R
----
G
---
T
----
F
L
V
R
E
S
E
T
-
T
K
G
A
Y
C
L
S
V
S
-----
D
F
-----
D
NAKGL
N
V
-
K
------
H
Y
K
I
R
K
L
D
S
G
--
G
F
Y
-
I
-
T
S
R
-
T
Q
F
N
S
L
Q
Q
L
V
A
----------
Y
-------
Y
S
K
H
-
A
D
G
L
C
H
R
L
--------
T
-----
T
---------
V
CPTSKP---
Q
------
T
Q
---
G
-
L
----------------------
A
----------------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
-
T
------
W
N
-----
G
--------
T
----
T
---
R
V
A
I
K
T
L
K
P
-
G
T
---
M
S
P
E
A
-
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
------
G
-----
E
------
T
G
K
-
Y
L
--
R
---------
L
P
--
Q
--
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
----
E
Y
L
Q
A
F
L
E
D
Y
F
T
---
556
HHSearch
59.18
33%
10
- C3 -
-
4FL2
1
KSYK_HUMAN
A:
[162-633]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
A
----------
H
E
K
M
P
W
F
H
G
K
I
S
R
E
E
S
E
Q
I
V
--
L
IGSK
T
----
N
----
G
---
K
----
F
L
I
R
A
R
D
N
-
N
-
G
S
Y
A
L
C
L
L
-----
H
E
-----
G
-----
K
V
-
L
------
H
Y
R
I
D
K
D
K
T
G
--
K
L
S
-
I
-
P
-
E
G
K
K
F
D
T
L
W
Q
L
V
E
----------
H
-------
Y
S
Y
K
-
A
D
G
L
L
R
V
L
--------
T
-----
V
---------
P
---------
C
------
Q
K
IGT---QREALPMDTEVYESPYADPEEI
R
----------------------
P
-
K
E
V
-------------------
Y
L
D
R
K
L
L
--------
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
------
Y
Q
-----
M
-----
K
KV
V
----
K
---
T
V
A
V
K
I
L
K
N
-
E
A
N
D
P
A
L
K
D
E
-
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
--
A
-
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
------
Q
-----
N
------
R
---
H
V
--
K
---------
D
K
--
N
--
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
---
T
Q
H
-----
Y
A
K
I
S
D
F
G
L
S
K
---
A
-
L
R
A
D
E
N
-
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
--
554
HHSearch
59.01
35%
23
- C3 -
-
1OPK
3
ABL1_MOUSE
A:
[51-478]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
V
A
S
G
D
N
T
L
S
I
T
--
K
G
E
K
L
R
V
L
G
Y
N
H
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
G
W
V
P
S
N
Y
----
I
TPVN
S
----------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
--
S
----
S
GI--
N
----
G
---
S
----
F
L
V
R
E
S
E
S
-
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
-----
G
-----
R
V
-
Y
------
H
Y
R
I
N
T
A
S
D
G
K-
L
Y
V
-
S
-
S
-
E
-
S
R
F
N
T
L
A
E
L
V
H
----------
H
-------
H
S
T
V
-
A
D
G
L
I
T
T
L
--------
H
-----
Y
---------
P
APKRNKPTI
Y
------
G
V
---
S
-
P
----------------------
N
----------------------
Y
-
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
-
D
T
---
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
-----
C
------
N
R
Q
-
E
V
--
S
---------
A
V
--
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
---
545
HHSearch
58.17
33%
35
- C3 -
-
2HCK
1
HCK_HUMAN
B:
[10-429]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
A
I
H
H
E
--
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
S
-
G
E
-
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
VARV
D
----
S
----------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
PGNM
L
----
G
---
S
----
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
DYDPR
Q
G
-----
D
-----
T
V
-
K
------
H
Y
K
I
R
T
L
D
N
G
--
G
F
Y
I
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
PCMSS----
K
---------
P
------
Q
K
---
P
-
W
----------------------
E
----------------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----------
K
--
H
----
T
---
K
V
A
V
K
T
M
K
P
-
G
S
---
M
S
V
E
A
-
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
--
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
-----
D
------
E
G
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
G
A
-------------
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
--
137
Blastp_CBE
57.93
41%
17
- C3 -
-
2SRC
1
SRC_HUMAN
A:
[67-428]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
--
L
----
N
----
A
ENPR
G
---
T
----
F
L
V
R
E
S
E
T
T
K
-
G
A
Y
C
L
S
V
S
D----
F
D
NAK--
G
-----
L
N
V
K
------
H
Y
K
I
R
K
L
-
D
S
GG
F
Y
I
-
T
-
S
-
R
-
T
Q
F
N
S
L
Q
Q
L
V
A
YYSKHADGLC
H
-------
R
L
T
T
-
V
C
P
T
S
K
P
Q
-----------------------------------------
T
Q
---
G
-
L
----------------------
A
----------------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
-
T
------
W
N
-----
G
--------
T
----
T
---
R
V
A
I
K
T
L
K
P
G
T
M
S
-
P
E
---
A
-
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
--
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
------
G
-----
E
T-----
G
-
K
-
Y
L
--
R
---------
L
P
--
Q
--
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
D
N
E
Y
-
T
-
A
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
-------------------
557
HHSearch
57.72
32%
-4
- C3 -
-
4FL3
1
KSYK_HUMAN
A:
[161-631]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
A
----------
H
E
K
M
P
W
F
H
G
K
I
S
R
E
E
S
E
Q
I
V
--
L
IGSK
T
----
N
----
G
---
K
----
F
L
I
R
A
R
D
N
-
N
-
G
S
Y
A
L
C
L
L
-----
H
E
-----
G
-----
K
V
-
L
------
H
Y
R
I
D
K
D
K
T
G
--
K
L
S
-
I
-
P
-
E
G
K
K
F
D
T
L
W
Q
L
V
E
----------
H
-------
Y
S
Y
K
-
A
D
G
L
L
R
V
L
--------
T
-----
V
---------
P
---------
C
------
Q
K
--------------------------------------------------------REALPMDTEVFESPFADPE
E
I
R
P
K
E
V
YLDRKLLT
L
-
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
-
Y
------
Y
Q
-----
M
-----
K
KV
V
----
K
---
T
V
A
V
K
I
L
K
N
-
E
A
N
D
P
A
L
K
D
E
-
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
-
A
--
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
------
Q
-----
N
------
R
---
H
V
--
K
---------
D
K
--
N
--
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
---
T
Q
H
-----
Y
A
K
I
S
D
F
G
L
S
K
---
A
-
L
R
A
--------------
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----
A
A
V
E
L
R
L
R
N
Y
Y
Y
---
553
HHSearch
57.58
35%
24
- C3 -
-
2FO0
4
ABL1_HUMAN
A:
[48-474]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
V
A
S
G
D
N
--
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
G
W
V
P
S
N
Y
----
I
TPVN
S
----------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
--
S
----
S
GI--
N
----
G
---
S
----
F
L
V
R
E
S
E
S
-
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
-----
G
-----
R
V
-
Y
------
H
Y
R
I
N
T
A
S
D
G
--
K
L
Y
-
V
S
S
-
E
-
S
R
F
N
T
L
A
E
L
V
H
----------
H
-------
H
S
T
V
-
A
D
G
L
I
T
T
L
--------
H
-----
Y
PAPKRNKPT
V
---------
Y
------
G
V
---
S
-
P
----------------------
N
----------------------
Y
-
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
-
D
T
---
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
-----
C
------
N
R
Q
-
E
V
--
N
---------
A
V
--
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
----
7
PsiBlast_PDB
57.22
39%
-7
- C3 -
-
4XEY
1
ABL1_HUMAN
B:
[7-381]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
-
N
A
A
E
Y
L
--
L
----
S
----
S
----
G
ING
S
----
F
L
V
R
E
S
E
S
-
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
-----
G
-----
R
V
-
Y
------
H
Y
R
I
N
T
A
-
S
D
GK
L
Y
V
-------
S
R
F
N
T
L
A
E
L
V
H
----------
H
HSTVADG
L
I
T
T
L
H
Y
P
A
P
K
-------------------------------------------------------------------------------------------------Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
------
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
---
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
8
PsiBlast_PDB
56.87
38%
7
- C3 -
-
5MO4
2
ABL1_HUMAN
A:
[92-476]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
N
Y
I
T
P
V
N
----
S
---------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
-
N
A
A
E
Y
L
--
L
----
S
----
S
----
G
ING
S
----
F
L
V
R
E
S
E
S
-
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
-----
G
-----
R
V
-
Y
------
H
Y
R
I
N
T
A
-
S
D
GK
L
Y
V
-
S
-
S
-
E
-
S
R
F
N
T
L
A
E
L
V
H
----------
H
HSTVADG
L
I
T
T
L
H
Y
P
A
P
K
R
N
--------
K
-----
P
---------
T
---------
V
------
Y
G
---
V
-
S
----------------------
P
----------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D--
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
-------------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
552
HHSearch
56.47
38%
3
- C3 -
-
4XEY
1
ABL1_HUMAN
B:
[7-383]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
--
S
----
S
GI--
N
----
G
---
S
----
F
L
V
R
E
S
E
S
-
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
-----
G
-----
R
V
-
Y
------
H
Y
R
I
N
T
A
S
D
G
--
K
L
Y
-
V
-----
S
R
F
N
T
L
A
E
L
V
H
----------
H
-------
H
S
T
V
-
A
D
G
L
I
T
T
L
--------
H
-----
Y
PAPK---------------------------------------------------------------------------
Y
-
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
------
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
----
T
---
M
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
-----
C
------
N
R
Q
-
E
V
--
N
---------
A
V
--
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
---
307
Blastp_CBE
56.42
40%
-151
- C3 -
-
3PIZ
1
A:
[10-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
-----
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
-----------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
555
HHSearch
56.19
32%
1
- C3 -
-
4K2R
1
ZAP70_HUMAN
A:
[155-598]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
T
----
A
----------
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
--
Y
SGAQ
T
----
D
----
G
---
K
----
F
L
L
R
P
R
K
E
-
Q
-
G
T
Y
A
L
S
L
I
-----
Y
G
-----
K
-----
T
V
-
Y
------
H
Y
L
I
S
Q
D
K
A
G
--
K
Y
C
-
I
-
P
-
E
G
T
K
F
D
T
L
W
Q
L
V
E
----------
Y
-------
L
K
L
K
-
A
D
G
L
I
Y
C
L
--------
K
-----
E
ACPNS---------------------------D
K
----------------------
P
RPMPMDTSVYESPYSDPEELKD
K
-
K
L
F
-------------------
L
K
R
D
N
L
L
--------
I
-
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
-
V
------
Y
R
-----
M
RK---
K
--
Q
----
I
---
D
V
A
I
K
V
L
K
Q
-
G
T
E
-
K
A
D
T
E
E
-
M
M
R
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
Q
-
A
--
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
------
G
-----
K
------
R
-
E
-
E
I
--
P
---------
V
S
--
N
--
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
---
N
R
H
-----
Y
A
K
I
S
D
F
G
L
S
----------------------
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
----
L
T
V
E
Q
R
M
R
A
C
Y
Y
---
372
Blastp_CBE
56.05
37%
27
- C3 -
-
1QCF
1
HCK_HUMAN
A:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
T
L
-
D
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
E
D
N
E
Y
-
T
-
A
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
339
Blastp_CBE
55.97
37%
32
- C3 -
-
5H0E
1
HCK_HUMAN
A:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
T
L
-
D
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
E
D
N
E
Y
-
T
-
A
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
374
Blastp_CBE
55.92
40%
-149
- C3 -
-
5JRS
1
B:
[5-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
--
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
------
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----------------
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
--------------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
337
Blastp_CBE
55.84
37%
29
- C3 -
-
5H0H
1
HCK_HUMAN
A:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
T
L
-
D
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
E
D
N
E
Y
-
T
-
A
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
257
Blastp_CBE
55.58
40%
-162
- C3 -
-
5XYZ
1
BTK_HUMAN
A:
[4-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
-------
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
---
M
S
-
E
D
-------
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
----------------
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---------------------
F
P
V
R
W
S
P
P
E
V
L
M
---
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
341
Blastp_CBE
55.15
37%
31
- C3 -
-
5H09
1
HCK_HUMAN
A:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
T
L
-
D
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
E
D
N
E
Y
-
T
-
A
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
349
Blastp_CBE
55.04
37%
19
- C3 -
-
3VS6
1
HCK_HUMAN
A:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
T
L
-
D
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
---------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
369
Blastp_CBE
54.91
37%
24
- C3 -
-
2C0O
1
HCK_HUMAN
A:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
T
L
-
D
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
364
Blastp_CBE
54.84
37%
18
- C3 -
-
3VRY
1
HCK_HUMAN
B:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
T
L
-
D
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
---------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
371
Blastp_CBE
54.55
37%
28
- C3 -
-
2C0I
1
HCK_HUMAN
A:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
T
L
-
D
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
348
Blastp_CBE
54.56
37%
23
- C3 -
-
3VS6
1
HCK_HUMAN
B:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
T
L
-
D
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
---------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
360
Blastp_CBE
54.55
37%
27
- C3 -
-
3VS0
1
HCK_HUMAN
B:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
T
L
-
D
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
347
Blastp_CBE
54.36
37%
23
- C3 -
-
3VS7
1
HCK_HUMAN
A:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
T
L
-
D
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
550
HHSearch
54.09
35%
18
- C3 -
-
5MO4
2
ABL1_HUMAN
A:
[51-478]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
V
A
S
G
D
N
T
L
--
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
G
W
V
P
S
N
Y
----
I
TPVN
S
----------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
--
S
----
S
GI--
N
----
G
---
S
----
F
L
V
R
E
S
E
S
-
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
-----
G
-----
R
V
-
Y
------
H
Y
R
I
N
T
A
S
D
G
K-
L
Y
V
-
S
-
S
-
E
-
S
R
F
N
T
L
A
E
L
V
H
----------
H
-------
H
S
T
V
-
A
D
G
L
I
T
T
L
--------
H
-----
Y
PAPKRNKPT
V
---------
Y
------
G
V
---
S
-
P
----------------------
N
----------------------
Y
-
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
-
D
-----
E
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------
E
-----
C
------
N
R
Q
-
E
V
--
N
---------
A
V
--
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
-------------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
---
370
Blastp_CBE
54.09
37%
26
- C3 -
-
2C0I
1
HCK_HUMAN
B:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
T
L
-
D
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
41
Blastp_CBE
54.07
44%
-47
- C3 -
-
2Z60
1
ABL1_MOUSE
A:
[6-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
---
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
358
Blastp_CBE
54.05
37%
24
- C3 -
-
3VS1
1
HCK_HUMAN
B:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
T
L
-
D
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
367
Blastp_CBE
54.01
37%
31
- C3 -
-
2C0T
1
HCK_HUMAN
A:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
-------
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
356
Blastp_CBE
53.98
37%
23
- C3 -
-
3VS2
1
HCK_HUMAN
B:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
T
L
-
D
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
350
Blastp_CBE
53.86
37%
27
- C3 -
-
3VS5
1
HCK_HUMAN
B:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
-------
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
558
HHSearch
53.76
31%
15
- C3 -
-
2OZO
1
ZAP70_HUMAN
A:
[155-598]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----
T
----
A
----------
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
--
Y
SGAQ
T
----
D
----
G
---
K
----
F
L
L
R
P
R
K
E
-
Q
-
G
T
Y
A
L
S
L
I
-----
Y
G
-----
K
-----
T
V
-
Y
------
H
Y
L
I
S
Q
D
K
A
G
--
K
Y
C
-
I
-
P
-
E
G
T
K
F
D
T
L
W
Q
L
V
E
----------
Y
-------
L
K
L
K
-
A
D
G
L
I
Y
C
L
--------
K
EACPN----------------------------------------------------------MDTSVFESPFSDPEELKD----
K
-
K
L
F
-------------------
L
K
R
D
N
L
L
--------
I
-
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
-
V
------
Y
R
-----
M
RK---
K
--
Q
----
I
---
D
V
A
I
K
V
L
K
Q
-
G
T
E
-
K
A
D
T
E
E
-
M
M
R
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
Q
-
A
--
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
------
G
-----
K
------
R
-
E
-
E
I
--
P
---------
V
S
--
N
--
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
---
N
R
H
-----
Y
A
K
I
S
D
F
G
L
S
K
---
A
-
L
G
---------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
----
L
T
V
E
Q
R
M
R
A
C
Y
Y
---
368
Blastp_CBE
53.70
37%
23
- C3 -
-
2C0O
1
HCK_HUMAN
B:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
T
L
-
D
N
GG
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
92
Blastp_CBE
53.52
44%
-42
- C3 -
-
2QOH
1
ABL1_MOUSE
A:
[6-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
---
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
365
Blastp_CBE
53.47
37%
29
- C3 -
-
3VRY
1
HCK_HUMAN
A:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
-------
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
---------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
30
Blastp_CBE
53.44
44%
-49
- C3 -
-
3OY3
1
ABL1_MOUSE
B:
[6-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
351
Blastp_CBE
53.39
37%
38
- C3 -
-
3VS5
1
HCK_HUMAN
A:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
T
----G-
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
63
Blastp_CBE
53.18
44%
-46
- C3 -
-
2HZI
1
ABL1_HUMAN
B:
[10-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
----
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
109
Blastp_CBE
53.16
44%
-37
- C3 -
-
3HMI
1
ABL2_HUMAN
A:
[25-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
E
--
E
---------
V
T
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
V
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
----
A
E
T
H
Q
A
F
E
T
M
-----
353
Blastp_CBE
53.10
37%
31
- C3 -
-
3VS4
1
HCK_HUMAN
A:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
-------
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
E
--------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
98
Blastp_CBE
53.13
43%
-45
- C3 -
-
3DK3
1
ABL1_MOUSE
A:
[4-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
----
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
F
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
24
Blastp_CBE
53.12
44%
-38
- C3 -
-
3QRJ
1
ABL1_HUMAN
B:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
78
Blastp_CBE
53.11
44%
-46
- C3 -
-
1OPJ
2
ABL1_MOUSE
B:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
42
Blastp_CBE
53.10
44%
-45
- C3 -
-
3QRK
1
ABL1_HUMAN
A:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
91
Blastp_CBE
53.01
44%
-41
- C3 -
-
2QOH
1
ABL1_MOUSE
B:
[6-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
---
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
39
Blastp_CBE
52.99
44%
-45
- C3 -
-
3IK3
1
ABL1_MOUSE
B:
[6-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
214
Blastp_CBE
52.95
40%
-47
- C3 -
-
6S90
1
BTK_HUMAN
A:
[3-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
58
Blastp_CBE
52.95
44%
-42
- C3 -
-
3PYY
1
ABL1_HUMAN
A:
[19-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
----
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
366
Blastp_CBE
52.94
37%
36
- C3 -
-
2C0T
1
HCK_HUMAN
B:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
T
----G-
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
110
Blastp_CBE
52.90
44%
-48
- C3 -
-
3GVU
2
ABL2_HUMAN
A:
[25-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
E
--
E
---------
V
T
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
V
V
K
V
A
D
F
G
L
S
R
-------
G
D
T
Y
-
T
-----
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
----
A
E
T
H
Q
A
F
E
T
M
-----
27
Blastp_CBE
52.75
43%
-33
- C3 -
-
2G1T
1
ABL1_HUMAN
D:
[2-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
---
S
-
P
----------------------
N
----------------------
Y
-
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
38
Blastp_CBE
52.74
44%
-36
- C3 -
-
4ZOG
5
ABL1_HUMAN
A:
[5-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
64
Blastp_CBE
52.73
44%
-35
- C3 -
-
2HZI
1
ABL1_HUMAN
A:
[10-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
29
Blastp_CBE
52.64
43%
-35
- C3 -
-
2G1T
1
ABL1_HUMAN
B:
[5-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
----------------------
N
----------------------
Y
-
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
20
PsiBlast_PDB
52.64
43%
-48
- C3 -
-
3OY3
1
ABL1_MOUSE
A:
[6-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
334
Blastp_CBE
52.58
40%
-45
- C3 -
-
5BQ0
4
A:
[19-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
---------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
266
Blastp_CBE
52.58
40%
-44
- C3 -
-
5VFI
9
A:
[7-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
23
Blastp_CBE
52.61
44%
-40
- C3 -
-
4TWP
1
ABL1_HUMAN
B:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
84
Blastp_CBE
52.60
44%
-46
- C3 -
-
1FPU
1
ABL1_MOUSE
B:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---------
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
52
Blastp_CBE
52.59
44%
-43
- C3 -
-
6NPV
2
ABL1_HUMAN
A:
[19-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
------
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
172
Blastp_CBE
52.58
42%
-47
- C3 -
-
3SXS
1
A:
[5-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
E
E
I
--------
T
-
L
L
K
E
L
G
S
G
Q
F
G
V
V
K
L
G
-
K
------
W
K
-----
G
-----
Q
--
Y
----
D
----
V
A
V
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
-
K
E
-
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
------
S
-----
H
------
G
-
K
-
G
L
--
E
---------
P
S
--
Q
--
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
---
R
D
L
-----
C
V
K
V
S
D
F
G
M
T
R
---
Y
-
V
L
D
D
Q
Y
-
V
-
S
S
V
G
T
K
-
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
-
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
----
Q
Q
L
L
S
S
I
E
P
L
R
E
---
90
Blastp_CBE
52.56
44%
-43
- C3 -
-
3KF4
1
ABL1_MOUSE
A:
[6-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
------
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
54
Blastp_CBE
52.56
44%
-40
- C3 -
-
6NPU
2
ABL1_HUMAN
A:
[19-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
------
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
59
Blastp_CBE
52.55
44%
-43
- C3 -
-
3CS9
1
ABL1_HUMAN
D:
[10-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
------------------------
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
326
Blastp_CBE
52.45
43%
-40
- C3 -
-
4MKC
3
A:
[71-341]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-
Q
------
V
S
-----------
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
A
G
Y
-
Y
-
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
28
Blastp_CBE
52.49
43%
-34
- C3 -
-
2G1T
1
ABL1_HUMAN
C:
[7-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
127
Blastp_CBE
52.45
44%
-43
- C3 -
-
4M0Z
2
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
R
E
-
G
A
M
-
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
R
---
F
-
V
L
D
D
Q
Y
-
T
-
S
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
88
Blastp_CBE
52.42
44%
-38
- C3 -
-
3KFA
1
ABL1_MOUSE
A:
[6-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
203
Blastp_CBE
52.40
43%
-49
- C3 -
-
4FOD
2
A:
[37-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-
Q
------
V
S
-----------
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
A
---------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
357
Blastp_CBE
52.41
37%
35
- C3 -
-
3VS2
1
HCK_HUMAN
A:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
T
L
---G-
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
196
Blastp_CBE
52.40
43%
-54
- C3 -
-
4FOB
1
A:
[57-327]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-
Q
------
V
S
-----------
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPR--------------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
A
--------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
15
PsiBlast_PDB
52.37
43%
-37
- C3 -
-
2G1T
1
ABL1_HUMAN
A:
[7-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
86
Blastp_CBE
52.35
44%
-43
- C3 -
-
5HU9
13
ABL1_HUMAN
A:
[10-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
-----------
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
120
Blastp_CBE
52.33
44%
-45
- C3 -
-
2HYY
1
ABL1_HUMAN
A:
[8-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
-D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
--
A
VV
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
89
Blastp_CBE
52.33
44%
-43
- C3 -
-
3KF4
1
ABL1_MOUSE
B:
[6-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
---
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
126
Blastp_CBE
52.32
44%
-44
- C3 -
-
4M12
1
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
R
E
-
G
A
M
-
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
R
---
F
-
V
L
D
D
Q
Y
-
T
-
S
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
232
Blastp_CBE
52.28
43%
-59
- C3 -
-
4CCB
1
A:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-
Q
------
V
---------------
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPR--------------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
33
Blastp_CBE
52.30
43%
-38
- C3 -
-
2G2H
1
ABL1_HUMAN
B:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
76
Blastp_CBE
52.29
44%
-40
- C3 -
-
3K5V
2
ABL1_MOUSE
A:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D-
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
18
PsiBlast_PDB
52.28
43%
-42
- C3 -
-
4TWP
1
ABL1_HUMAN
A:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
-----
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
67
Blastp_CBE
52.26
44%
-37
- C3 -
-
6HD4
2
ABL1_MOUSE
B:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
---
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
40
Blastp_CBE
52.25
44%
-54
- C3 -
-
3IK3
1
ABL1_MOUSE
A:
[6-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
----------
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
359
Blastp_CBE
52.23
37%
27
- C3 -
-
3VS1
1
HCK_HUMAN
A:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
-----------
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
M
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
259
Blastp_CBE
52.21
40%
-43
- C3 -
-
6NFH
7
A:
[7-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
318
Blastp_CBE
52.18
40%
-39
- C3 -
-
5P9K
1
A:
[15-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
260
Blastp_CBE
52.11
40%
-43
- C3 -
-
6N9P
1
A:
[7-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
311
Blastp_CBE
52.17
40%
-41
- C3 -
-
4YHF
2
B:
[14-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
131
Blastp_CBE
52.15
44%
-43
- C3 -
-
4HCT
1
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
R
E
-
G
A
M
-
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
R
---
F
-
V
L
D
D
Q
Y
-
T
-
S
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
258
Blastp_CBE
52.14
40%
-41
- C3 -
-
6OMU
1
A:
[7-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
80
Blastp_CBE
52.13
44%
-35
- C3 -
-
1M52
3
ABL1_MOUSE
B:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
26
Blastp_CBE
52.12
43%
-40
- C3 -
-
3UE4
1
ABL1_HUMAN
B:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
--
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
195
Blastp_CBE
52.10
43%
-51
- C3 -
-
4FOC
1
A:
[57-327]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-
Q
------
V
S
-----------
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
----------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
87
Blastp_CBE
52.11
44%
-38
- C3 -
-
3KFA
1
ABL1_MOUSE
B:
[6-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
68
Blastp_CBE
52.10
44%
-40
- C3 -
-
6HD4
3
ABL1_MOUSE
A:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D-
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
343
Blastp_CBE
52.08
37%
29
- C3 -
-
4LUE
3
HCK_HUMAN
A:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
T
----G-
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
-
G
S
------
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
128
Blastp_CBE
52.06
44%
-46
- C3 -
-
4M0Y
2
A:
[5-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
R
E
-
G
A
M
-
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
R
---
F
-
V
L
D
D
Q
Y
-
T
-
S
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
48
Blastp_CBE
52.07
44%
-34
- C3 -
-
4WA9
1
ABL1_HUMAN
B:
[7-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
44
Blastp_CBE
52.06
44%
-38
- C3 -
-
3QRI
1
ABL1_HUMAN
A:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
19
PsiBlast_PDB
52.06
43%
-44
- C3 -
-
3QRJ
1
ABL1_HUMAN
A:
[12-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
-----
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
250
Blastp_CBE
52.03
43%
-52
- C3 -
-
2XB7
1
A:
[22-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-
Q
------
V
------------
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
--------------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
45
Blastp_CBE
52.03
44%
-41
- C3 -
-
2HIW
1
ABL1_HUMAN
B:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
50
Blastp_CBE
52.01
44%
-34
- C3 -
-
2F4J
1
ABL1_HUMAN
A:
[7-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
123
Blastp_CBE
52.00
44%
-45
- C3 -
-
4M15
2
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
R
E
-
G
A
M
-
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
R
---
F
-
V
L
D
D
Q
Y
-
T
-
S
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
388
Blastp_CBE
51.95
40%
-42
- C3 -
-
4OT5
3
A:
[20-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
A
------
R
-
H
-
A
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
383
Blastp_CBE
51.99
40%
-41
- C3 -
-
4RFZ
3
A:
[20-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
A
------
R
-
H
-
A
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
112
Blastp_CBE
51.96
44%
-44
- C3 -
-
2XYN
4
ABL2_HUMAN
B:
[26-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
--D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
E
--
E
---------
V
T
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
V
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
----
A
E
T
H
Q
A
F
E
T
M
-----
34
Blastp_CBE
51.96
43%
-33
- C3 -
-
2G2H
1
ABL1_HUMAN
A:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
386
Blastp_CBE
51.95
40%
-41
- C3 -
-
4OTQ
3
A:
[20-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
A
------
R
-
H
-
A
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
125
Blastp_CBE
51.93
44%
-46
- C3 -
-
4M13
1
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
R
E
-
G
A
M
-
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
R
---
F
-
V
L
D
D
Q
Y
-
T
-
S
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
323
Blastp_CBE
51.88
40%
-39
- C3 -
-
5P9F
6
A:
[15-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
263
Blastp_CBE
51.88
40%
-50
- C3 -
-
6DI3
1
A:
[7-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
--
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
------------
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
122
Blastp_CBE
51.88
44%
-43
- C3 -
-
4XLI
1
ABL2_MOUSE
A:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
----
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
S
-
R
E
--
E
---------
V
T
--
A
VV
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
V
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
----
A
E
T
H
Q
A
F
E
T
M
-----
46
Blastp_CBE
51.86
44%
-39
- C3 -
-
2HIW
1
ABL1_HUMAN
A:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
36
Blastp_CBE
51.86
43%
-34
- C3 -
-
2G2F
1
ABL1_HUMAN
A:
[7-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
132
Blastp_CBE
51.85
44%
-44
- C3 -
-
3T9T
3
A:
[3-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
R
E
-
G
A
M
-
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
T
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
R
---
F
-
V
L
D
D
Q
Y
-
T
-
S
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
71
Blastp_CBE
51.84
44%
-39
- C3 -
-
3MSS
2
ABL1_MOUSE
B:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
-------
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
-
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
322
Blastp_CBE
51.80
40%
-44
- C3 -
-
5P9G
1
A:
[15-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
82
Blastp_CBE
51.81
44%
-44
- C3 -
-
1IEP
1
ABL1_MOUSE
B:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
79
Blastp_CBE
51.81
44%
-36
- C3 -
-
1OPJ
2
ABL1_MOUSE
A:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
97
Blastp_CBE
51.80
43%
-44
- C3 -
-
3DK3
1
ABL1_MOUSE
B:
[4-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
----
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
F
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
330
Blastp_CBE
51.79
42%
-43
- C3 -
-
5AAA
1
A:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-
Q
------
V
---------------
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
124
Blastp_CBE
51.78
44%
-43
- C3 -
-
4M14
2
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
R
E
-
G
A
M
-
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
R
---
F
-
V
L
D
D
Q
Y
-
T
-
S
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
81
Blastp_CBE
51.77
44%
-34
- C3 -
-
1M52
1
ABL1_MOUSE
A:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
32
Blastp_CBE
51.76
43%
-30
- C3 -
-
2G2I
1
ABL1_HUMAN
A:
[4-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
P
----------------------
N
----------------------
Y
-
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
---
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
83
Blastp_CBE
51.75
44%
-41
- C3 -
-
1IEP
1
ABL1_MOUSE
A:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
324
Blastp_CBE
51.69
40%
-39
- C3 -
-
6NZM
2
D:
[16-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
177
Blastp_CBE
51.72
43%
-44
- C3 -
-
4ANS
1
A:
[45-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
-
Q
------
V
---------------
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
A
D
F
G
M
A
R
---
D
-
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
62
Blastp_CBE
51.71
44%
-36
- C3 -
-
3CS9
1
ABL1_HUMAN
A:
[10-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
----
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
361
Blastp_CBE
51.66
37%
42
- C3 -
-
3VS0
1
HCK_HUMAN
A:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
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R
D
S
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T
K
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Y
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L
S
V
R
------
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-----
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P
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QGDTVK
H
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F
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P
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R
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S
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S
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L
Q
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V
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K
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---------
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------
M
S
---
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K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
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K
K
L
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G
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------
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N
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--------
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----
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V
A
V
K
T
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K
----
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G
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L
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A
N
V
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L
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V
T
--
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P
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K
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L
L
D
F
L
K
------
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E
------
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-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
227
Blastp_CBE
51.70
43%
-44
- C3 -
-
4CMU
1
A:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-
Q
------
V
---------------
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
265
Blastp_CBE
51.69
40%
-40
- C3 -
-
6DI0
1
A:
[7-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
331
Blastp_CBE
51.64
42%
-43
- C3 -
-
5AA9
1
A:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-
Q
------
V
---------------
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
378
Blastp_CBE
51.68
40%
-40
- C3 -
-
6AUA
2
A:
[2-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
A
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
321
Blastp_CBE
51.66
40%
-40
- C3 -
-
5P9H
1
A:
[15-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
221
Blastp_CBE
51.65
43%
-44
- C3 -
-
5KZ0
1
A:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-
Q
------
V
---------------
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
382
Blastp_CBE
51.60
40%
-40
- C3 -
-
4RG0
1
A:
[20-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
A
------
R
-
H
-
A
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
111
Blastp_CBE
51.64
44%
-42
- C3 -
-
2XYN
4
ABL2_HUMAN
C:
[27-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
--
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
E
--
E
---------
V
T
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
V
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
----
A
E
T
H
Q
A
F
E
T
M
-----
66
Blastp_CBE
51.64
44%
-42
- C3 -
-
6HD6
2
ABL1_MOUSE
A:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
--
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
213
Blastp_CBE
51.63
40%
-38
- C3 -
-
6S90
1
B:
[3-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
43
Blastp_CBE
51.61
44%
-37
- C3 -
-
3QRI
1
ABL1_HUMAN
B:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
-----
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
117
Blastp_CBE
51.60
44%
-36
- C3 -
-
2HYY
1
ABL1_HUMAN
D:
[6-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
--
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
--
A
VV
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
175
Blastp_CBE
51.59
43%
-39
- C3 -
-
4CLJ
1
A:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-
Q
------
V
------------
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
225
Blastp_CBE
51.56
43%
-50
- C3 -
-
4CNH
2
B:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-
Q
------
V
------------
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPR--------------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
A
S
Y
-------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
85
Blastp_CBE
51.57
44%
-40
- C3 -
-
1FPU
1
ABL1_MOUSE
A:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
113
Blastp_CBE
51.56
44%
-42
- C3 -
-
2XYN
2
ABL2_HUMAN
A:
[26-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
--D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
E
--
E
---------
V
T
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
V
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
----
A
E
T
H
Q
A
F
E
T
M
-----
325
Blastp_CBE
51.53
40%
-41
- C3 -
-
6NZM
1
BTK_HUMAN
A:
[16-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
---
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
384
Blastp_CBE
51.47
40%
-41
- C3 -
-
4RFY
3
A:
[20-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
A
------
R
-
H
-
A
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
251
Blastp_CBE
51.49
43%
-43
- C3 -
-
4ANQ
1
A:
[45-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
-
Q
------
V
---------------
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
A
D
F
G
M
A
R
---
D
-
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
264
Blastp_CBE
51.48
40%
-43
- C3 -
-
6DI1
1
A:
[7-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
75
Blastp_CBE
51.47
44%
-38
- C3 -
-
3K5V
2
ABL1_MOUSE
B:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
---
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
197
Blastp_CBE
51.45
43%
-41
- C3 -
-
4CD0
1
A:
[45-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-
Q
------
V
------------
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
121
Blastp_CBE
51.42
44%
-34
- C3 -
-
4XLI
1
B:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
----
G
E
V
Y
V
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
S
-
R
E
--
E
---------
V
T
--
A
VV
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
V
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
----
A
E
T
H
Q
A
F
E
T
M
-----
119
Blastp_CBE
51.42
44%
-38
- C3 -
-
2HYY
1
ABL1_HUMAN
B:
[6-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
-
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
--
A
VV
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
96
Blastp_CBE
51.42
43%
-40
- C3 -
-
6BL8
1
ABL1_HUMAN
A:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
F
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
242
Blastp_CBE
51.39
43%
-46
- C3 -
-
4TT7
5
A:
[21-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
----
G
E
V
Y
E
G
-
Q
------
V
------------
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPR--------------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
A
S
----
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
176
Blastp_CBE
51.39
43%
-42
- C3 -
-
2YFX
1
A:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
-
Q
------
V
---------------
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
65
Blastp_CBE
51.39
44%
-36
- C3 -
-
6HD6
1
ABL1_MOUSE
B:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
---
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
118
Blastp_CBE
51.36
44%
-36
- C3 -
-
2HYY
1
ABL1_HUMAN
C:
[6-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
-
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
--
A
VV
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
---
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
230
Blastp_CBE
51.35
43%
-47
- C3 -
-
4CLI
1
A:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-
Q
------
V
---------------
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
373
Blastp_CBE
51.33
40%
-45
- C3 -
-
5T18
1
A:
[5-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----------------
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
229
Blastp_CBE
51.32
43%
-43
- C3 -
-
4CMO
1
A:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-
Q
------
V
---------------
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
219
Blastp_CBE
51.31
40%
-40
- C3 -
-
5KUP
4
A:
[4-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
220
Blastp_CBE
51.28
40%
-39
- C3 -
-
4RX5
4
A:
[4-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
104
Blastp_CBE
51.27
44%
-35
- C3 -
-
2HZ0
1
ABL1_HUMAN
A:
[6-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
--
A
VV
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
218
Blastp_CBE
51.17
40%
-38
- C3 -
-
5VGO
5
A:
[4-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
31
Blastp_CBE
51.19
43%
-38
- C3 -
-
2G2I
1
ABL1_HUMAN
B:
[7-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
----
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
16
PsiBlast_PDB
51.17
43%
-37
- C3 -
-
3UE4
1
ABL1_HUMAN
A:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
375
Blastp_CBE
51.16
40%
-41
- C3 -
-
5JRS
2
BTK_HUMAN
A:
[5-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----------------
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
303
Blastp_CBE
51.09
40%
-36
- C3 -
-
5J87
1
BTK_HUMAN
A:
[12-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
385
Blastp_CBE
51.10
40%
-42
- C3 -
-
4OTR
3
A:
[20-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
A
------
R
-
H
-
A
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
73
Blastp_CBE
51.09
44%
-34
- C3 -
-
3MS9
2
ABL1_MOUSE
B:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
---
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
93
Blastp_CBE
51.07
44%
-41
- C3 -
-
2E2B
1
ABL1_HUMAN
B:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
-----
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
----------
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
94
Blastp_CBE
51.05
44%
-37
- C3 -
-
2E2B
1
ABL1_HUMAN
A:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
----
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-----
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
201
Blastp_CBE
51.00
43%
-54
- C3 -
-
4FNZ
1
A:
[31-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
-
Q
------
V
S
-----
G
-----
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
---------------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
312
Blastp_CBE
50.99
40%
-41
- C3 -
-
4YHF
3
BTK_HUMAN
A:
[14-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
317
Blastp_CBE
50.98
40%
-47
- C3 -
-
5P9L
1
A:
[15-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
----
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
-------------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
301
Blastp_CBE
50.97
40%
-35
- C3 -
-
5J87
1
BTK_HUMAN
C:
[12-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
532
Blastp_CBE
50.95
41%
-8
- C3 -
-
2QOC
2
A:
[13-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
T
N
I
--------
S
-
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
-
R
------
L
K
LPS--
K
-----
K
--
E
----
I
---
S
V
A
I
K
T
L
K
V
-
G
Y
T
-
E
K
Q
R
R
D
-
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
-
K
S
-
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
------
K
-----
H
------
D
-
A
-
Q
F
--
T
---------
V
I
--
Q
--
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
----------------
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
-
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
----
E
Q
I
V
S
I
L
D
K
L
-----
327
Blastp_CBE
50.89
43%
-34
- C3 -
-
3L9P
4
A:
[71-341]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-
Q
------
V
S
-----
G
-----
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
A
G
Y
-
Y
-
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
69
Blastp_CBE
50.91
44%
-38
- C3 -
-
3MSS
2
ABL1_MOUSE
D:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
-------
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
-
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
25
Blastp_CBE
50.90
43%
-41
- C3 -
-
4YC8
3
ABL1_HUMAN
B:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
------
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
95
Blastp_CBE
50.89
43%
-43
- C3 -
-
6BL8
1
ABL1_HUMAN
B:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
---
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
F
-
T
-
A
H
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
37
Blastp_CBE
50.89
44%
-37
- C3 -
-
4ZOG
2
ABL1_HUMAN
B:
[6-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
---
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
17
PsiBlast_PDB
50.88
43%
-47
- C3 -
-
4YC8
3
ABL1_HUMAN
A:
[8-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
------
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
----
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
254
Blastp_CBE
50.86
43%
-49
- C3 -
-
6E0R
1
A:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
----
V
Y
E
G
-
Q
------
V
------------
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
-------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
247
Blastp_CBE
50.84
43%
-48
- C3 -
-
5FTQ
2
A:
[22-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-
Q
------
V
------------
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
----------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
-
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
233
Blastp_CBE
50.76
43%
-55
- C3 -
-
2XP2
1
A:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
-
Q
------
V
---------------
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPR--------------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
211
Blastp_CBE
50.76
43%
-44
- C3 -
-
3AOX
5
A:
[47-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
----
G
E
V
Y
E
G
-
Q
------
V
------------
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
A
---------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
199
Blastp_CBE
50.76
43%
-67
- C3 -
-
5IUH
1
A:
[31-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
-----
G
E
V
Y
E
G
-
Q
------
V
S
-----
G
--------
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPR--------------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
-------------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
72
Blastp_CBE
50.76
44%
-36
- C3 -
-
3MSS
2
ABL1_MOUSE
A:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
-------
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
-
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
223
Blastp_CBE
50.73
43%
-49
- C3 -
-
4CTC
1
A:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
----
G
E
V
Y
E
G
-
Q
------
V
---------------
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
534
Blastp_CBE
50.59
41%
-10
- C3 -
-
3FXX
1
A:
[40-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
T
N
I
--------
S
-
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
-
R
------
L
K
LPS--
K
-----
K
--
E
----
I
---
S
V
A
I
K
T
L
K
V
-
G
Y
T
-
E
K
Q
R
R
D
-
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
-
K
S
-
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
------
K
-----
H
------
D
-
A
-
Q
F
--
T
---------
V
I
--
Q
--
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
-----------
G
--
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
-
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
----
E
Q
I
V
S
I
L
D
K
L
-----
202
Blastp_CBE
50.59
43%
-64
- C3 -
-
6MX8
1
A:
[21-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
-
Q
------
V
------------
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP-------------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
-------------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
70
Blastp_CBE
50.51
44%
-37
- C3 -
-
3MSS
2
ABL1_MOUSE
C:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
-------
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
-
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
224
Blastp_CBE
50.49
43%
-45
- C3 -
-
4CTB
1
A:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
---
F
G
E
V
Y
E
G
-
Q
------
V
---------------
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
238
Blastp_CBE
50.48
44%
-43
- C3 -
-
3MJ2
1
A:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
R
E
-
G
A
M
-
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
R
---
F
-
V
L
D
D
Q
Y
-
T
-
S
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
A
I
-----
255
Blastp_CBE
50.46
40%
-37
- C3 -
-
3OCS
2
A:
[4-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
212
Blastp_CBE
50.40
40%
-36
- C3 -
-
6AUB
1
A:
[1-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
74
Blastp_CBE
50.33
44%
-38
- C3 -
-
3MS9
2
ABL1_MOUSE
A:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
-------
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
---
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
47
Blastp_CBE
50.24
44%
-39
- C3 -
-
3OXZ
1
ABL1_MOUSE
A:
[6-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
-------
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
----------------
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
244
Blastp_CBE
50.23
43%
-42
- C3 -
-
4Z55
3
A:
[43-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-
Q
------
V
------------
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP------------------
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
A
G
Y
-
Y
--
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
295
Blastp_CBE
50.20
44%
-55
- C3 -
-
4L7S
1
ITK_HUMAN
A:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
R
E
-
G
A
M
-
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
231
Blastp_CBE
50.18
43%
-41
- C3 -
-
4CCU
1
A:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
-
Q
------
V
---------------
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
215
Blastp_CBE
50.16
43%
-41
- C3 -
-
5AAC
1
A:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
-
Q
------
V
---------------
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
Y
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
216
Blastp_CBE
50.14
43%
-43
- C3 -
-
5A9U
1
A:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
-
Q
------
V
---------------
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
Y
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
115
Blastp_CBE
50.13
44%
-38
- C3 -
-
2HZ4
1
ABL1_HUMAN
B:
[6-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
-----
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
--
A
VV
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
342
Blastp_CBE
49.92
37%
28
- C3 -
-
4LUE
4
HCK_HUMAN
B:
[67-435]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
--
L
----
A
----
P
----
G
---
N
MLGS
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
------
D
-----
Y
-----
D
P
-
R
QGDTVK
H
Y
K
I
R
T
----G-
F
Y
I
-
S
-
P
-
R
-
S
T
F
S
T
L
Q
E
L
V
D
----------
H
-------
Y
K
K
G
-
N
D
G
L
C
Q
K
L
--------
S
-----
V
---------
P
---------
C
------
M
S
---
S
-
K
----------------------
P
QKPWE-----------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
-
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-
T
------
Y
N
-----
K
--------
H
----
T
---
K
V
A
V
K
T
M
K
----
P
---------
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
--
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
------
S
D----
E
------
G
-
S
-
K
Q
--
P
---------
L
P
--
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
---
A
S
L
-----
V
C
K
I
A
D
F
G
L
A
R
---
V
-
I
----------------
P
I
K
W
T
A
P
E
A
I
N
---
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
------------
300
Blastp_CBE
49.85
40%
-30
- C3 -
-
5J87
1
D:
[12-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
L
S
N
I
L
D
V
-----
228
Blastp_CBE
49.84
43%
-55
- C3 -
-
4CMT
1
A:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
-
Q
------
V
---------------
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPR--------------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
465
Blastp_CBE
49.83
42%
-22
- C3 -
-
5I9V
1
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
-----
S
--
S
GKKE
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VL------------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
102
Blastp_CBE
49.80
43%
-66
- C3 -
-
3DK7
1
ABL1_MOUSE
A:
[4-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
----
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
T
-
A
-
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
328
Blastp_CBE
49.78
42%
-40
- C3 -
-
5AAB
1
A:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
--
G
E
V
Y
E
G
-
Q
------
V
---------------
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
Y
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
55
Blastp_CBE
49.69
44%
-45
- C3 -
-
6NPE
3
ABL1_HUMAN
B:
[19-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
-------
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
198
Blastp_CBE
49.64
43%
-19
- C3 -
-
5IUI
1
A:
[31-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-
Q
------
V
S
-----
G
P----
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
A
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
410
Blastp_CBE
49.51
41%
-35
- C3 -
-
6BLN
2
A:
[4-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
------------
222
Blastp_CBE
49.53
43%
-50
- C3 -
-
5IMX
1
A:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-
Q
------
V
------------
S
--
P
----
L
---
Q
V
A
V
K
T
L
-----------
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
35
Blastp_CBE
49.51
43%
-38
- C3 -
-
2G2F
1
ABL1_HUMAN
B:
[9-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
-----
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
77
Blastp_CBE
49.50
44%
-39
- C3 -
-
2HZN
1
ABL1_MOUSE
A:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
---
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
--D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
329
Blastp_CBE
49.48
42%
-40
- C3 -
-
5AA8
1
A:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
-
Q
------
V
---------------
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
Y
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
53
Blastp_CBE
49.44
44%
-44
- C3 -
-
6NPU
5
ABL1_HUMAN
B:
[19-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
-------
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
---------------------
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
60
Blastp_CBE
49.42
44%
-42
- C3 -
-
3CS9
1
ABL1_HUMAN
C:
[10-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
-----
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
61
Blastp_CBE
49.36
44%
-35
- C3 -
-
3CS9
1
ABL1_HUMAN
B:
[10-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
---
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
57
Blastp_CBE
49.27
44%
-40
- C3 -
-
3PYY
3
ABL1_HUMAN
B:
[19-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
-------
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
---------------------
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
249
Blastp_CBE
49.23
43%
-51
- C3 -
-
2XBA
1
A:
[22-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
-------
V
Y
E
G
-
Q
------
V
------------
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
100
Blastp_CBE
49.23
44%
-65
- C3 -
-
3DK6
1
ABL1_MOUSE
A:
[4-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
--
G
Q
F
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
-----
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
T
-
A
-
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
236
Blastp_CBE
49.12
44%
-54
- C3 -
-
4MF1
1
B:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
----
A
M
-
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
R
---------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
A
I
-----
467
Blastp_CBE
49.08
41%
-2
- C3 -
-
6IN0
2
?
A:
[5-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
T
N
I
--------
S
-
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
-
R
------
L
K
LPS--
K
-----
K
--
E
----
I
---
S
V
A
I
K
T
L
K
V
-
G
Y
T
-
E
K
Q
R
R
D
-
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
-
K
S
-
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
------
K
-----
H
------
D
-
A
-
Q
F
--
T
---------
V
I
--
Q
--
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VL-------------------
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
-
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
----
E
Q
I
V
S
I
L
D
K
L
-----
253
Blastp_CBE
49.05
43%
-57
- C3 -
-
6EBW
1
A:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
--
F
G
E
V
Y
E
G
-
Q
------
V
S
-----------
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP-------------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-----------------
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
298
Blastp_CBE
49.03
44%
-57
- C3 -
-
4KIO
2
ITK_HUMAN
B:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
-----------
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
248
Blastp_CBE
49.05
43%
-16
- C3 -
-
5FTO
1
A:
[22-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-
Q
------
V
S
-----
G
M----
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
---------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
204
Blastp_CBE
49.03
43%
-48
- C3 -
-
4DCE
1
B:
[37-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
----
E
V
Y
E
G
-
Q
------
V
S
-----------
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
---------------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
12
PsiBlast_PDB
49.04
47%
-20
- C3 -
-
4UEU
1
?
A:
[3-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-
D
K
W
-------------------
E
I
P
R
S
E
I
--------
T
-
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
-
K
------
W
R
-----
N
-----
Y
--
N
----
I
---
E
V
A
V
K
T
L
K
E
G
T
M
S
-
V
E
---
E
-
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
-
K
E
-
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D-----
C
-----
E
------
G
-
H
-
T
V
--
N
---------
A
Q
--
A
--
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
N
-----
V
V
K
V
A
D
F
G
L
A
R
---
L
-
I
------------
A
K
-
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
-
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
----
A
E
T
L
H
A
L
E
T
M
-----
101
Blastp_CBE
49.03
43%
-65
- C3 -
-
3DK7
1
ABL1_MOUSE
B:
[4-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
----
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
T
-
A
-
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
411
Blastp_CBE
49.02
41%
-34
- C3 -
-
6BKW
4
A:
[4-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
------------
413
Blastp_CBE
48.96
41%
-37
- C3 -
-
6BKE
1
A:
[4-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
------------
200
Blastp_CBE
48.97
43%
-58
- C3 -
-
5IUG
1
A:
[31-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
----
G
E
V
Y
E
G
-
Q
------
V
------------
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP-----------------
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
------------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
51
Blastp_CBE
48.96
44%
-41
- C3 -
-
6NPV
5
ABL1_HUMAN
B:
[19-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
-------
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
---------------------
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
144
Blastp_CBE
48.87
44%
-59
- C3 -
-
3V8T
1
B:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
----
A
M
-
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
226
Blastp_CBE
48.83
43%
-43
- C3 -
-
4CNH
1
ALK_HUMAN
A:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
------
E
V
Y
E
G
-
Q
------
V
------------
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
510
Blastp_CBE
48.80
39%
-41
- C3 -
-
2ETM
1
FAK1_HUMAN
A:
[9-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
------
Y
M
-----
S
-----
P
--
E
----
N
PAL
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
R
---
Y
-
M
E
-------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
500
Blastp_CBE
48.79
39%
-30
- C3 -
-
4K9Y
1
A:
[10-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
------
Y
M
-----
S
-----
P
--
E
----
N
PAL
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
R
---
Y
-
M
E
D
S
T
Y
Y
K
-
A
S
K
G
--
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
493
Blastp_CBE
48.71
40%
-39
- C3 -
-
4C7T
1
A:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
------
M
S
-----
P
-----
E
--
N
PA--
M
---
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
F
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
A
T
D
-----
C
V
K
L
G
D
F
G
L
S
R
---
Y
-
M
---------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
147
Blastp_CBE
48.70
44%
-47
- C3 -
-
3V5L
1
ITK_HUMAN
C:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
R
E
-
G
A
M
-
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
155
Blastp_CBE
48.60
44%
-44
- C3 -
-
1SM2
1
ITK_HUMAN
A:
[1-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
R
E
-
G
A
M
-
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
146
Blastp_CBE
48.59
44%
-51
- C3 -
-
3V5L
1
D:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
-
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
R
---
A
M
-
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
-----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
474
Blastp_CBE
48.58
42%
-2
- C3 -
-
4UXL
1
A:
[33-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
--------
T
-
L
R
L
L
L
G
S
G
A
F
G
E
V
Y
E
G
-
T
AVDILG
V
G
-----
S
-----
G
--
E
----
I
---
K
V
A
V
K
T
L
K
K
-
G
S
T
-
D
Q
E
K
I
E
-
F
L
K
E
A
H
L
M
S
K
F
N
H
P
N
I
L
K
Q
L
G
V
C
L
-
L
N
-
E
P
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
------
K
-----
A
RMATFY
G
-
P
-
L
L
--
T
---------
L
V
--
D
--
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
---
V
K
D
YTSPR
I
V
K
I
G
D
F
G
L
A
R
---
D
-
I
Y
K
----------
E
G
L
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
Q
P
Y
P
A
H
S
-
N
L
D
V
L
N
Y
V
Q
T
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
----
H
R
I
Q
D
Q
L
Q
L
F
R
N
---
463
Blastp_CBE
48.57
42%
-28
- C3 -
-
5I9X
5
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
---------E---
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
------
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
412
Blastp_CBE
48.52
41%
-33
- C3 -
-
6BKH
1
A:
[5-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
-
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
-
K
------
W
R
-----
G
-----
Q
--
Y
----
D
----
V
A
I
K
M
I
K
E
G
S
M
S
-
E
D
---
E
-
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
------
E
-----
M
------
R
-
H
-
R
F
--
Q
---------
T
Q
--
Q
--
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
---
D
Q
G
-----
V
V
K
V
S
D
F
G
L
S
R
---
Y
-
V
L
D
D
E
Y
-
T
-
S
S
V
G
-
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
----
K
I
L
------------
516
Blastp_CBE
48.45
39%
-46
- C3 -
-
4GU6
1
B:
[10-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
------
Y
M
-----
S
-----
P
--
E
----
N
PAL
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
R
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
483
Blastp_CBE
48.49
40%
-42
- C3 -
-
4D58
1
?
B:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
------
M
S
-----
P
-----
E
--
N
PA--
M
---
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
F
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
A
T
D
-----
C
V
K
L
G
D
F
G
L
S
R
---
Y
-
M
---------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
417
Blastp_CBE
48.47
42%
-44
- C3 -
-
6Q7E
1
?
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
---------E---
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
148
Blastp_CBE
48.45
44%
-54
- C3 -
-
3V5L
1
ITK_HUMAN
B:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
----
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
R
------
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
434
Blastp_CBE
48.44
42%
-5
- C3 -
-
5NKH
1
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
-----
S
--
S
GKKE
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
-
T
-
T
S
G
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
426
Blastp_CBE
48.43
42%
-40
- C3 -
-
6HET
1
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
---------E---
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
205
Blastp_CBE
48.42
43%
-26
- C3 -
-
4DCE
1
ALK_HUMAN
A:
[37-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
-
Q
------
V
S
------P----
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
--------------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
496
Blastp_CBE
48.35
40%
-44
- C3 -
-
2JKK
1
?
A:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
------
M
S
-----
P
-----
E
--
N
PA--
M
---
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
F
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
A
T
D
-----
C
V
K
L
G
D
F
G
L
S
R
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
252
Blastp_CBE
48.40
43%
-51
- C3 -
-
6EDL
1
A:
[30-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
-
Q
------
V
S
-----------
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
----------------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
459
Blastp_CBE
48.37
42%
-21
- C3 -
-
5IA0
10
EPHA2_HUMAN
B:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
-----
S
---KE--
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VL-------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
154
Blastp_CBE
48.35
44%
-49
- C3 -
-
1SM2
1
B:
[2-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
R
E
-
G
A
M
-
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
152
Blastp_CBE
48.34
44%
-47
- C3 -
-
1SNU
1
B:
[2-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
R
E
-
G
A
M
-
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
299
Blastp_CBE
48.29
44%
-51
- C3 -
-
4KIO
2
ITK_HUMAN
A:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
--------
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
509
Blastp_CBE
48.26
39%
-44
- C3 -
-
2ETM
1
B:
[9-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
------
Y
M
-----
S
-----
P
--
E
----
N
PAL
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
R
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
490
Blastp_CBE
48.25
40%
-44
- C3 -
-
4D4S
1
B:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
------
M
S
-----
P
-----
E
--
N
PA--
M
---
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
F
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
A
T
D
-----
C
V
K
L
G
D
F
G
L
S
R
---
Y
-
M
---------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
507
Blastp_CBE
48.22
39%
-48
- C3 -
-
2IJM
1
B:
[9-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
------
Y
M
-----
S
-----
P
--
E
----
N
PAL
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
279
Blastp_CBE
48.21
43%
2
- C3 -
-
3LCS
3
A:
[48-318]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-
Q
------
V
S
-----
G
MPNDP
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
A
G
Y
-
Y
-
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
451
Blastp_CBE
48.19
42%
-26
- C3 -
-
5NK0
1
A:
[25-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
-----
S
--
S
GKKE
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
518
Blastp_CBE
48.12
39%
-42
- C3 -
-
3PXK
1
B:
[10-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
------
Y
M
-----
S
-----
P
--
E
----
N
PAL
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
G
L
-----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
508
Blastp_CBE
48.18
39%
-48
- C3 -
-
2IJM
1
FAK1_HUMAN
A:
[9-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
------
Y
M
-----
S
-----
P
--
E
----
N
PAL
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
435
Blastp_CBE
48.12
42%
3
- C3 -
-
5NKG
1
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
-----
S
--
S
GKKE
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
-
T
-
T
S
G
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
436
Blastp_CBE
48.11
42%
1
- C3 -
-
5NKF
1
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
--------
S
GKKE
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
-
T
-
T
S
G
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
153
Blastp_CBE
48.12
44%
-45
- C3 -
-
1SNU
1
ITK_HUMAN
A:
[1-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
R
E
-
G
A
M
-
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
421
Blastp_CBE
48.11
42%
-38
- C3 -
-
6HEY
1
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
-----
S
---E---
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
---------------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
471
Blastp_CBE
48.08
40%
-37
- C3 -
-
2JKM
1
A:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
------
M
S
-----
P
-----
E
--
N
PA--
M
---
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
R
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
488
Blastp_CBE
48.07
40%
-44
- C3 -
-
4D4V
2
B:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
------
M
S
-----
P
-----
E
--
N
PA--
M
---
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
F
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
A
T
D
-----
C
V
K
L
G
D
F
G
------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
103
Blastp_CBE
48.00
44%
-46
- C3 -
-
2HZ0
1
ABL1_HUMAN
B:
[6-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
------
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
----
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
--
A
VV
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
143
Blastp_CBE
47.98
44%
-52
- C3 -
-
3V8W
1
ITK_HUMAN
A:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
R
--
G
A
M
-
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
498
Blastp_CBE
47.96
39%
-43
- C3 -
-
4KAB
1
B:
[10-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
------
Y
M
-----
S
-----
P
--
E
-----PAL
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
R
---
Y
-
M
---------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
441
Blastp_CBE
47.93
42%
-20
- C3 -
-
5NKA
2
A:
[25-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
-----
S
--
S
GKKE
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
---------------------
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
437
Blastp_CBE
47.92
42%
-6
- C3 -
-
5NKE
1
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
-----
S
--
S
GKKE
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
-
T
-
T
S
G
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
452
Blastp_CBE
47.85
42%
-32
- C3 -
-
5NJZ
1
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
---------KKE-
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
----------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
472
Blastp_CBE
47.83
39%
-43
- C3 -
-
2JKQ
1
A:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
------
Y
M
-----
S
-----
P
--
E
----
N
PAL
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
517
Blastp_CBE
47.79
39%
-29
- C3 -
-
4GU6
1
FAK1_HUMAN
A:
[10-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
------
Y
M
-----
S
-------------
N
PAL
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
R
---
Y
-
M
E
D
S
T
Y
Y
K
-
A
S
K
G
--
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
149
Blastp_CBE
47.85
44%
-52
- C3 -
-
3V5L
1
ITK_HUMAN
A:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
-----
M
-
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
450
Blastp_CBE
47.84
42%
-16
- C3 -
-
5NK1
1
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
----------------KKE-
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
------
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
430
Blastp_CBE
47.83
42%
-12
- C3 -
-
6FNH
11
EPHA2_HUMAN
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
--------
S
GKKE
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-------------
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
497
Blastp_CBE
47.82
39%
-44
- C3 -
-
6I8Z
1
A:
[9-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
------
Y
M
-----
S
-----
P
--
E
----
N
PAL
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
R
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
105
Blastp_CBE
47.79
43%
-35
- C3 -
-
2V7A
1
ABL1_HUMAN
B:
[8-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
T
-
A
-
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
278
Blastp_CBE
47.78
43%
8
- C3 -
-
3LCT
3
A:
[48-318]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
-
Q
------
V
S
-----
G
MPNDP
S
--
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP
S
-----
Q
------
P
-
S
-
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
R
A
G
Y
-
Y
-
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
495
Blastp_CBE
47.73
40%
-46
- C3 -
-
2JKO
1
A:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
------
M
S
-----
P
-----
E
--
N
PA--
M
---
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
F
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
A
T
D
-----
C
V
K
L
G
D
F
G
L
-----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
296
Blastp_CBE
47.67
44%
-51
- C3 -
-
4KIO
3
D:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
-------
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
519
Blastp_CBE
47.65
39%
-42
- C3 -
-
3PXK
1
FAK1_HUMAN
A:
[10-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
------
Y
M
-----
S
-----
P
--
E
----
N
PAL
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
G
------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
489
Blastp_CBE
47.58
40%
-38
- C3 -
-
4D4V
2
FAK1_CHICK
A:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
------
M
S
-----
P
-----
E
--
N
PA--
M
---
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
F
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
A
T
D
-----
C
V
K
L
G
D
F
---------------------
G
--
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
21
Blastp_CBE
47.63
39%
-4
- C3 -
-
4XEY
1
ABL1_HUMAN
A:
[116-381]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
----
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
416
Blastp_CBE
47.59
42%
-40
- C3 -
-
6Q7F
1
?
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
---------E---
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
99
Blastp_CBE
47.58
44%
-62
- C3 -
-
3DK6
1
ABL1_MOUSE
B:
[5-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
-------
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
-----
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
S
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
T
-
A
-
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
473
Blastp_CBE
47.52
39%
-49
- C3 -
-
2J0M
1
?
B:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
------
Y
M
-----
S
-----
P
--
E
----
N
PAL
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
G
L
-----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
145
Blastp_CBE
47.56
44%
-55
- C3 -
-
3V8T
1
ITK_HUMAN
A:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
R
E
-
G
A
M
-
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
-------
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
538
Blastp_CBE
47.55
44%
-24
- C3 -
-
4MXZ
1
SRC_HUMAN
A:
[10-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
-
T
------
W
N
-----
G
--------
T
----
T
---
R
V
A
I
K
T
L
K
P
G
T
M
S
-
P
E
---
A
-
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
--
E
P
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
------
G
-----
E
T-----
G
-
K
-
Y
L
--
R
---------
L
P
--
Q
--
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
E
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
-------------------
107
Blastp_CBE
47.52
43%
-31
- C3 -
-
2GQG
2
ABL1_HUMAN
B:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
T
-
A
-
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
428
Blastp_CBE
47.51
42%
-25
- C3 -
-
6FNH
5
C:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
---------GKKE
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
445
Blastp_CBE
47.47
42%
-11
- C3 -
-
5NK6
1
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
----------------KKE-
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
-----
G
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
449
Blastp_CBE
47.46
42%
-15
- C3 -
-
5NK2
2
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
----------------KKE-
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
------
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
530
Blastp_CBE
47.38
42%
-32
- C3 -
-
2XYU
7
A:
[16-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
V
G
E
F
G
E
V
C
S
G
-
R
------
L
K
-----
V
-----
P
--
G
KRE-
I
---
C
V
A
I
K
T
L
K
A
-
G
Y
T
-
D
K
Q
R
R
D
-
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
-
K
C
-
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
R
------
K
-----
N
------
D
-
G
-
R
F
--
T
---------
V
I
--
Q
--
L
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
-------------------------
I
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
----
G
Q
I
V
N
M
L
D
K
L
-----
525
Blastp_CBE
47.43
42%
-31
- C3 -
-
2Y6O
1
A:
[22-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
V
G
E
F
G
E
V
C
S
G
-
R
------
L
K
-----
V
-----
P
--
G
KRE-
I
---
C
V
A
I
K
T
L
K
A
-
G
Y
T
-
D
K
Q
R
R
D
-
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
-
K
C
-
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
R
------
K
-----
N
------
D
-
G
-
R
F
--
T
---------
V
I
--
Q
--
L
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
-------------------------
I
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
----
G
Q
I
V
N
M
L
D
K
L
-----
514
Blastp_CBE
47.40
39%
-48
- C3 -
-
4KAO
1
B:
[10-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
------
Y
M
-----
S
-----
P
--------PAL
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
G
------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
442
Blastp_CBE
47.38
42%
-10
- C3 -
-
5NK9
1
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
----------------KKE-
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
-
T
-
T
--
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
502
Blastp_CBE
47.25
39%
-46
- C3 -
-
4K8A
1
FAK1_HUMAN
A:
[10-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
------
Y
M
-----
S
-----
P
--------PAL
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
G
------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
494
Blastp_CBE
47.29
40%
-41
- C3 -
-
4BRX
1
FAK1_CHICK
A:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
-
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
------
M
S
-----
P
-----
E
--
N
PA--
M
---
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
F
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
A
T
D
-----
C
V
K
L
G
D
F
G
L
S
R
---
Y
-
M
---------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
106
Blastp_CBE
47.28
43%
-34
- C3 -
-
2V7A
1
ABL1_HUMAN
A:
[7-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
T
-
A
-
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
439
Blastp_CBE
47.22
42%
-13
- C3 -
-
5NKC
2
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
----------------KKE-
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
---------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
515
Blastp_CBE
47.27
39%
-53
- C3 -
-
4KAO
1
FAK1_HUMAN
A:
[10-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
------
Y
M
-----
S
--------------PAL
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
G
------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
444
Blastp_CBE
47.25
42%
-15
- C3 -
-
5NK7
1
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
----------------KKE-
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
------
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
150
Blastp_CBE
47.22
44%
-57
- C3 -
-
3V5J
1
B:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
-----
M
-
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
108
Blastp_CBE
47.22
43%
-32
- C3 -
-
2GQG
2
ABL1_HUMAN
A:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
K
T
L
K
E
D
T
M
E
-
V
E
---
E
-
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
T
-
A
-
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
193
Blastp_CBE
47.21
39%
8
- C3 -
-
3LW0
3
IGF1R_HUMAN
B:
[8-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
A
R
E
K
I
--------
T
-
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
-
V
------
A
K
-----
G
VVKDE
P
--
E
----
T
---
R
V
A
I
K
T
V
N
E
-
A
A
S
-
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
-----
L
------
R
-
P
---PP
S
---------
L
S
--
K
--
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
-----
T
V
K
I
G
D
F
G
M
T
R
---
D
-
I
Y
E
T
D
Y
-
Y
-
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
-------
192
Blastp_CBE
47.17
39%
7
- C3 -
-
3LW0
3
IGF1R_HUMAN
C:
[8-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
A
R
E
K
I
--------
T
-
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
-
V
------
A
K
-----
G
VVKDE
P
--
E
----
T
---
R
V
A
I
K
T
V
N
E
-
A
A
S
-
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
-----
L
------
R
-
P
---PP
S
---------
L
S
--
K
--
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
-----
T
V
K
I
G
D
F
G
M
T
R
---
D
-
I
Y
E
T
D
Y
-
Y
-
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
-------
454
Blastp_CBE
47.15
42%
-10
- C3 -
-
5IA4
1
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
---------------KKE-
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
-
T
-
T
S
G
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
478
Blastp_CBE
47.11
40%
-42
- C3 -
-
6GCX
1
FAK1_CHICK
A:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
------
M
S
-----
P
-----
E
--
N
PA--
M
---
A
V
A
I
K
T
C
K
N
---
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
F
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
A
T
D
-----
C
V
K
L
G
D
F
G
L
S
R
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
443
Blastp_CBE
47.10
42%
-21
- C3 -
-
5NK8
1
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
----
G
E
V
Y
K
G
-
M
------
L
K
-----
T
-----
S
--
S
GKKE
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
13
PsiBlast_PDB
47.08
47%
-16
- C3 -
-
4CSV
1
?
A:
[5-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
I
P
R
S
E
I
--------
T
-
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
-
K
------
W
R
-----
N
-----
Y
--
N
----
I
---
E
V
A
V
K
T
L
K
E
G
T
M
S
-
V
E
---
E
-
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
-
K
E
-
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D-----
C
-----------------
V
--
N
---------
A
Q
--
A
--
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
N
-----
V
V
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
-
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
----
A
E
T
L
H
A
L
E
T
M
-----
499
Blastp_CBE
47.07
39%
-54
* C3 *
-
4KAB
1
FAK1_HUMAN
A:
[10-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
------
Y
M
-----
S
-----
P
--------PAL
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
-------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
446
Blastp_CBE
47.06
42%
-3
- C3 -
-
5NK5
1
A:
[25-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
---
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
-----
S
--
S
GKKE
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
-
T
-
T
-
G
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
440
Blastp_CBE
47.00
42%
-10
- C3 -
-
5NKB
3
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
----------------KKE-
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
-
T
-
T
--
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
455
Blastp_CBE
47.04
42%
-28
- C3 -
-
5IA3
1
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
---------------KKE-
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
---------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
521
Blastp_CBE
47.02
39%
-40
- C3 -
-
4I4F
2
A:
[12-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
------
Y
M
-----
S
--------------PAL
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
---------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
194
Blastp_CBE
47.00
39%
10
- C3 -
-
3LW0
2
IGF1R_HUMAN
A:
[8-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
A
R
E
K
I
--------
T
-
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
-
V
------
A
K
-----
G
VVKDE
P
--
E
----
T
---
R
V
A
I
K
T
V
N
E
-
A
A
S
-
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
-----
L
------
R
-
P
---PP
S
---------
L
S
--
K
--
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
-----
T
V
K
I
G
D
F
G
M
T
R
---
D
-
I
Y
E
T
D
Y
-
Y
-
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
-------
537
Blastp_CBE
46.99
44%
-22
- C3 -
-
4MXZ
1
SRC_HUMAN
B:
[11-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
-
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
-
T
------
W
N
-----
G
--------
T
----
T
---
R
V
A
I
K
T
L
K
P
G
T
M
S
-
P
E
---
A
-
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
--
E
P
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
------
G
-----
E
T-----
G
-
K
-
Y
L
--
R
---------
L
P
--
Q
--
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
---
E
N
L
-----
V
C
K
V
A
D
F
G
L
A
R
---
L
-
I
---------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
-------------------
475
Blastp_CBE
46.97
42%
0
- C3 -
-
3ZBF
1
A:
[33-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
--------
T
-
L
R
L
L
L
G
S
---
G
E
V
Y
E
G
-
T
AVDILG
V
G
-----
S
-----
G
--
E
----
I
---
K
V
A
V
K
T
L
K
K
-
G
S
T
-
D
Q
E
K
I
E
-
F
L
K
E
A
H
L
M
S
K
F
N
H
P
N
I
L
K
Q
L
G
V
C
L
-
L
N
-
E
P
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
------
K
-----
A
RMATFY
G
-
P
-
L
L
--
T
---------
L
V
--
D
--
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
---
V
K
D
YTSPR
I
V
K
I
G
D
F
G
L
A
R
---
D
-
I
Y
--------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
Q
P
Y
P
A
H
S
-
N
L
D
V
L
N
Y
V
Q
T
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
----
H
R
I
Q
D
Q
L
Q
L
F
R
N
---
462
Blastp_CBE
46.94
42%
-14
- C3 -
-
5I9Y
4
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
---------KKE-
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
-----------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
424
Blastp_CBE
46.93
42%
-29
- C3 -
-
6HEV
1
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
----------------KKE-
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
----------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
504
Blastp_CBE
46.92
39%
-47
- C3 -
-
4GU9
1
FAK1_HUMAN
A:
[10-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
------
Y
M
-----
S
-----
P
--------PAL
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
-------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
423
Blastp_CBE
46.90
42%
-28
- C3 -
-
6HEW
1
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
----------------KKE-
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
------------------
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
526
Blastp_CBE
46.89
42%
-26
- C3 -
-
2Y6M
3
A:
[22-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
V
G
E
F
G
E
V
C
S
G
-
R
------
L
K
-----
V
-----
P
--
G
KRE-
I
---
C
V
A
I
K
T
L
K
A
-
G
Y
T
-
D
K
Q
R
R
D
-
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
-
K
C
-
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
R
------
K
-----
N
------
D
-
G
-
R
F
--
T
---------
V
I
--
Q
--
L
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
--------------------------
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
----
G
Q
I
V
N
M
L
D
K
L
-----
332
Blastp_CBE
46.86
42%
-52
- C3 -
-
4FNY
1
A:
[31-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
-
Q
------
V
S
-----
G
--------
P
----
L
---
Q
V
A
V
K
T
L
P
E
-
V
C
S
-
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPRP-----------------
S
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
----------------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
482
Blastp_CBE
46.68
40%
-35
- C3 -
-
4D5H
1
FAK1_CHICK
A:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
------
M
S
-----
P
-----
E
--
N
PA--
M
---
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
F
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
A
T
D
-----
C
V
K
L
G
D
F
------------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
191
Blastp_CBE
46.65
39%
8
- C3 -
-
3LW0
2
D:
[8-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
A
R
E
K
I
--------
T
-
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
-
V
------
A
K
-----
G
VVKDE
P
--
E
----
T
---
R
V
A
I
K
T
V
N
E
-
A
A
S
-
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
-----
L
------
R
-
P
---PP
S
---------
L
S
--
K
--
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
-----
T
V
K
I
G
D
F
G
M
T
R
---
D
-
I
Y
E
T
D
Y
-
Y
-
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
-------
422
Blastp_CBE
46.63
42%
-29
- C3 -
-
6HEX
1
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
----------------KKE-
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
476
Blastp_CBE
46.59
39%
-50
- C3 -
-
3BZ3
1
A:
[4-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
------
Y
M
-----
S
-----
P
--------L--
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
R
---
Y
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
512
Blastp_CBE
46.54
44%
-34
- C3 -
-
3DKO
1
A:
[51-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
-
E
F
G
E
V
C
S
G
-
R
------
L
K
LPG--
K
-----
R
--
D
----
V
---
A
V
A
I
K
T
L
K
V
-
G
Y
T
-
E
K
Q
R
R
D
-
F
L
C
E
A
S
I
M
G
Q
F
D
H
P
N
V
V
H
L
E
G
V
V
T
-
R
G
-
K
P
V
M
I
V
I
E
F
M
E
N
G
A
L
D
A
F
L
R
------
K
-----
H
------
D
-
G
-
Q
F
--
T
---------
V
I
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
R
Y
L
A
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
-------------------------
P
V
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
-
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
A
P
M
D
C
P
A
G
L
H
Q
L
M
L
D
C
W
Q
K
E
R
A
E
R
P
K
F
----
E
Q
I
------------
427
Blastp_CBE
46.49
42%
-29
- C3 -
-
6HES
2
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
----------------KKE-
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
-----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
469
Blastp_CBE
46.47
42%
-17
- C3 -
-
1MQB
1
B:
[52-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
---------KE--
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VL------------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
433
Blastp_CBE
46.46
42%
-31
- C3 -
-
5NKI
1
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
----------------KKE-
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
282
Blastp_CBE
46.39
44%
-44
- C3 -
-
4QD6
2
B:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
--------
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
461
Blastp_CBE
46.37
42%
-18
- C3 -
-
5I9Z
1
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
--
G
E
V
Y
K
G
-
M
------
L
K
-----
T
---------KE--
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VL-------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
167
Blastp_CBE
46.34
39%
22
- C3 -
-
3I81
1
A:
[11-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
A
R
E
K
I
--------
T
-
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
-
V
------
A
K
-----
G
VVKDE
P
--
E
----
T
---
R
V
A
I
K
T
V
N
E
-
A
A
S
-
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
-----
L
------
R
-
P
-
E
---
E
NNPVLAPPS
L
S
--
K
--
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
-----
T
V
K
I
G
D
F
G
M
T
R
---
D
-
I
Y
E
T
D
Y
-
Y
-
R
-----
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
-------
522
Blastp_CBE
46.28
39%
-48
- C3 -
-
4I4E
1
A:
[12-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
------
Y
M
-----
S
-----
P
-------
N
PAL
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
-------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
209
Blastp_CBE
46.26
39%
12
- C3 -
-
3LVP
2
IGF1R_HUMAN
A:
[40-321]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
A
R
E
K
I
--------
T
-
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
-
V
------
A
K
-----
G
VVKDE
P
--
E
----
T
---
R
V
A
I
K
T
V
N
E
-
A
A
S
-
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
-----
L
------
R
-
P
-
E
M
--
E
PVLAPPS--
L
S
--
K
--
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
-----
T
V
K
I
G
D
F
G
M
T
R
---
D
-
I
Y
---------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
-------
456
Blastp_CBE
46.23
42%
14
- C3 -
-
5IA2
3
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
---------KE--
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
-
T
-
T
S
G
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
431
Blastp_CBE
46.22
42%
-27
- C3 -
-
6FNG
7
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
----------------KKE-
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
----------------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
470
Blastp_CBE
46.18
42%
-22
- C3 -
-
1MQB
1
EPHA2_HUMAN
A:
[52-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
---------KKE-
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
----------------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
447
Blastp_CBE
46.11
42%
16
- C3 -
-
5NK4
2
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
----------------KE--
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
-
T
-
T
S
G
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
458
Blastp_CBE
45.89
42%
-12
- C3 -
-
5IA0
6
C:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
---------GKKE
V
---
P
V
A
I
K
T
L
K
A
---
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
-----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
159
Blastp_CBE
45.83
39%
15
- C3 -
-
3QQU
1
IGF1R_HUMAN
B:
[3-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
----------------------
P
------------------------
D
E
W
-------------------
E
V
A
R
E
K
I
--------
T
-
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
-
V
------
A
K
-----
G
VVKDE
P
--
E
----
T
---
R
V
A
I
K
T
V
N
E
-
A
A
S
-
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
-----
L
------
R
--------PS-------
L
S
--
K
--
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
-----
T
V
K
I
G
D
F
G
M
T
R
---
D
-
I
Y
E
T
D
Y
-
Y
-
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
-------
457
Blastp_CBE
45.82
42%
5
- C3 -
-
5IA1
2
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
----------------KE--
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
----------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
528
Blastp_CBE
45.80
40%
-35
- C3 -
-
4EBV
3
A:
[35-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
------
M
S
-----
P
-----
E
--
N
PA--
L
---
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
G
L
----------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
161
Blastp_CBE
45.78
39%
23
- C3 -
-
4D2R
1
A:
[6-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
A
R
E
K
I
--------
T
-
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
-
V
------
A
K
-----
G
VVKDE
P
--
E
----
T
---
R
V
A
I
K
T
V
N
E
-
A
A
S
-
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
-----
L
------
R
-
P
-
E
M
--
E
NNPVLAPPS
L
S
--
K
--
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
-----
T
V
K
I
G
D
F
G
M
T
R
---
D
-
I
Y
E
T
D
Y
-
Y
-
R
K
--
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
-------
453
Blastp_CBE
45.73
42%
9
- C3 -
-
5IA5
2
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
-----
S
---KE--
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
-
T
-
T
S
G
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
158
Blastp_CBE
45.66
39%
16
- C3 -
-
3QQU
1
IGF1R_HUMAN
C:
[4-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------------------
D
E
W
-------------------
E
V
A
R
E
K
I
--------
T
-
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
-
V
------
A
K
-----
G
VVKDE
P
--
E
----
T
---
R
V
A
I
K
T
V
N
E
-
A
A
S
-
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
-----
L
------
R
-
P
-
E
M
---VLAPPS---
L
S
--
K
--
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
-----
T
V
K
I
G
D
F
G
M
T
R
---
D
-
I
Y
E
T
D
Y
-
Y
-
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
-------
438
Blastp_CBE
45.59
42%
10
- C3 -
-
5NKD
2
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
----------------KE--
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
------
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
277
Blastp_CBE
45.56
43%
-64
- C3 -
-
4JOA
1
A:
[48-318]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
--------
T
-
L
I
R
G
L
G
------
V
Y
E
G
-
Q
------
V
S
-------------------
L
---
Q
V
A
V
K
T
L
P
-----------
D
-
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
ETRPR-------------------
L
--
A
---------
M
L
--
D
--
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
-----
V
A
K
I
G
D
F
G
M
A
R
---
D
-
I
Y
------------
A
M
L
P
V
K
W
M
P
P
E
A
---
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------
283
Blastp_CBE
45.55
44%
-47
- C3 -
-
4QD6
2
ITK_HUMAN
A:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
-------
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
523
Blastp_CBE
45.49
39%
-43
- C3 -
-
1MP8
1
A:
[12-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
------
Y
M
-----
S
-----
P
--------PAL
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
--------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
429
Blastp_CBE
45.48
42%
20
- C3 -
-
6FNH
6
EPHA2_HUMAN
B:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
-----
S
---KE--
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
-----------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
527
Blastp_CBE
45.42
40%
-34
- C3 -
-
4EBW
1
A:
[35-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
------
M
S
--------------
N
PA--
L
---
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
G
L
----------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
536
Blastp_CBE
45.24
40%
21
- C3 -
-
4IBM
1
?
A:
[10-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
S
R
E
K
I
--------
T
-
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
-
N
------
A
R
DIIKG
E
-----
A
--
E
----
T
---
R
V
A
V
K
T
V
N
E
-
S
A
S
-
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
-
K
G
-
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
------
S
LRPEA
E
------
N
-
N
-
P
G
--
R
PPPT-----
L
Q
--
E
--
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
-----
T
V
K
I
G
D
F
G
M
T
R
---
D
-
I
Y
E
T
D
Y
-
Y
-
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
----
L
E
I
V
N
L
L
K
-------
561
Fugue
45.13
44%
-8
- C3 -
-
1BYG
1
CSK_HUMAN
A:
[15-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
-------------------
A
L
N
M
K
E
L
--------
K
-
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
-
D
------
Y
R
G------------------
N
---
K
V
A
V
K
C
I
K
-------
N
D
A
Q
A
-
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
---E
E
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
------
S
RG----------
R
-
S
-
V
L
--
G
---------
G
D
--
C
--
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
---
E
D
N
-----
V
A
K
V
S
D
F
G
-----------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L-
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
----
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
464
Blastp_CBE
45.15
42%
-2
- C3 -
-
5I9W
3
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
----------------KE--
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
-----------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
520
Blastp_CBE
45.14
39%
-39
- C3 -
-
4Q9S
1
A:
[12-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
-
I
------
Y
M
-----
S
-----
P
--------PAL
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
Y
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
--------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
170
Blastp_CBE
45.13
39%
14
- C3 -
-
1JQH
1
IGF1R_HUMAN
A:
[12-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
A
R
E
K
I
--------
T
-
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
-
V
------
A
K
-----
G
VVKDE
P
--
E
----
T
---
R
V
A
I
K
T
V
N
E
-
A
A
S
-
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
-----
L
------
R
-
P
-
E
----VLAPPS---
L
S
--
K
--
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
-----
T
V
K
I
G
D
F
G
M
T
-----------
Y
-
Y
-
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
-------
531
Blastp_CBE
45.06
39%
14
- C3 -
-
3D94
1
A:
[5-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
A
R
E
K
I
--------
T
-
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
-
V
------
A
K
-----
G
VVKDE
P
--
E
----
T
---
R
V
A
I
K
T
V
N
E
-
A
A
S
-
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
-----
L
------
R
--------PS-------
L
S
--
K
--
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
-----
T
V
K
I
G
D
F
G
M
T
R
---
D
-
I
Y
E
T
D
Y
-
Y
-
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
L
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
-------
49
Blastp_CBE
45.04
44%
-29
- C3 -
-
4WA9
1
ABL1_HUMAN
A:
[10-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
--------
T
-
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
-
V
------
W
K
-----
K
-----
Y
--
S
----
L
---
T
V
A
V
-------------------------
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
E
-
P
---
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
------------
E
------
C
-
N
-
R
Q
--
E
---------
V
N
AV
V
--
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
-----
L
V
K
V
A
D
F
G
L
S
R
---
L
-
M
T
G
D
T
Y
-
T
-
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----
448
Blastp_CBE
45.03
42%
8
- C3 -
-
5NK3
2
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
---------KE--
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
R
VLE
D
-
D
P
E
A
T
Y
-
T
----
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
420
Blastp_CBE
45.01
42%
4
- C3 -
-
6Q7B
1
?
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
---------KE--
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
------------------
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
169
Blastp_CBE
44.95
39%
12
- C3 -
-
1JQH
1
IGF1R_HUMAN
B:
[12-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
A
R
E
K
I
--------
T
-
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
-
V
------
A
K
-----
G
VVKDE
P
--
E
----
T
---
R
V
A
I
K
T
V
N
E
-
A
A
S
-
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
-----
L
------
R
-
P
------PPS------
L
S
--
K
--
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
-----
T
V
K
I
G
D
F
G
M
T
-----------
Y
-
Y
-
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
-------
415
Blastp_CBE
44.92
42%
1
- C3 -
-
6Q7G
1
?
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
---------KE--
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
168
Blastp_CBE
44.91
39%
15
- C3 -
-
1JQH
1
C:
[12-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
A
R
E
K
I
--------
T
-
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
-
V
------
A
K
-----
G
VVKDE
P
--
E
----
T
---
R
V
A
I
K
T
V
N
E
-
A
A
S
-
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
-----
L
------
R
-
P
-
E
----VLAPPS---
L
S
--
K
--
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
-----
T
V
K
I
G
D
F
G
M
T
-----------
Y
-
Y
-
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
-------
157
Blastp_CBE
44.90
39%
16
- C3 -
-
3QQU
1
D:
[4-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------------------------
D
E
W
-------------------
E
V
A
R
E
K
I
--------
T
-
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
-
V
------
A
K
-----
G
VVKDE
P
--
E
----
T
---
R
V
A
I
K
T
V
N
E
-
A
A
S
-
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
-----
L
------
R
-
P
-
E
M
---LAPPS----
L
S
--
K
--
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
-----
T
V
K
I
G
D
F
G
M
T
R
---
D
-
I
Y
E
T
D
Y
-
Y
-
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
-------
289
Blastp_CBE
44.80
44%
-38
- C3 -
-
4PPA
2
ITK_HUMAN
A:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
-----------
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
418
Blastp_CBE
44.83
42%
3
- C3 -
-
6Q7D
1
?
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
---------KE--
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
-----------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
181
Blastp_CBE
44.80
44%
10
- C3 -
-
3QGW
1
ITK_HUMAN
A:
[24-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
K
E
G
S
M
S
-
E
D
---
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
163
Blastp_CBE
44.76
39%
26
- C3 -
-
3NW6
1
A:
[11-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
A
R
E
K
I
--------
T
-
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
-
V
------
A
K
-----
G
VVKDE
P
--
E
----
T
---
R
V
A
I
K
T
V
N
E
-
A
A
S
-
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
-----
L
------
R
-
P
-
E
M
--
E
NNPVLAPPS
L
S
--
K
--
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
-----
T
V
K
I
G
D
F
G
M
T
R
---
D
-
I
Y
E
T
D
Y
-
Y
-
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
-------
239
Blastp_CBE
44.74
44%
-55
- C3 -
-
3MJ1
1
A:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
----------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
A
I
-----
419
Blastp_CBE
44.71
42%
7
- C3 -
-
6Q7C
1
?
A:
[23-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
---------KE--
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
------------------
G
--
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
460
Blastp_CBE
44.46
42%
8
- C3 -
-
5IA0
7
EPHA2_HUMAN
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
---------KE--
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
178
Blastp_CBE
44.44
44%
7
- C3 -
-
3QGY
1
B:
[23-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
K
E
G
S
M
S
-
E
D
---
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
286
Blastp_CBE
44.43
44%
-43
- C3 -
-
4PPB
2
B:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
-----------
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
425
Blastp_CBE
44.38
42%
2
- C3 -
-
6HEU
1
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
---------KE--
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
-----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
165
Blastp_CBE
44.28
39%
24
- C3 -
-
2OJ9
1
A:
[11-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
A
R
E
K
I
--------
T
-
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
-
V
------
A
K
-----
G
VVKDE
P
--
E
----
T
---
R
V
A
I
K
T
V
N
E
-
A
A
S
-
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
-----
L
------
R
-
P
-
E
----PPS------
L
S
--
K
--
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
-----
T
V
K
I
G
D
F
G
M
T
R
---
D
-
I
Y
E
T
D
Y
-
Y
-
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
-------
162
Blastp_CBE
44.28
39%
25
- C3 -
-
3NW7
1
A:
[11-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
A
R
E
K
I
--------
T
-
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
-
V
------
A
K
-----
G
VVKDE
P
--
E
----
T
---
R
V
A
I
K
T
V
N
E
-
A
A
S
-
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
-----
L
------
R
-
P
-
E
M
--
E
NNPVLAPPS
L
S
--
K
--
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
-----
T
V
K
I
G
D
F
G
M
T
R
---
D
-
I
Y
E
T
D
Y
-
Y
-
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
-------
293
Blastp_CBE
44.21
44%
-40
- C3 -
-
4MF0
2
ITK_HUMAN
A:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
-----
M
-
S
E
--
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
288
Blastp_CBE
44.21
44%
-41
- C3 -
-
4PPA
2
B:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
-----------
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
511
Blastp_CBE
44.11
39%
12
- C3 -
-
1K3A
1
A:
[3-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
A
R
E
K
I
--------
T
-
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
-
V
------
A
K
-----
G
VVKDE
P
--
E
----
T
---
R
V
A
I
K
T
V
N
E
-
A
A
S
-
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
------
S
-----
L
------
R
-
P
-
E
M
---PS-------
L
S
--
K
--
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
-----
T
V
K
I
G
D
F
G
M
T
R
---
D
I
E
T
D
------
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
L
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
-------
432
Blastp_CBE
44.11
42%
3
- C3 -
-
6FNF
1
A:
[25-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
-
M
------
L
K
-----
T
---------KE--
V
---
P
V
A
I
K
T
L
K
A
-
G
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
-
K
Y
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
------
E
-----
K
------
D
-
G
-
E
F
--
S
---------
V
L
--
Q
--
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
-----
V
C
K
V
S
D
F
G
L
S
-----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
----
A
D
I
V
S
I
L
D
K
L
-----
535
Blastp_CBE
44.04
40%
18
- C3 -
-
4IBM
1
?
B:
[10-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
S
R
E
K
I
--------
T
-
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
-
N
------
A
R
DIIKG
E
-----
A
--
E
----
T
---
R
V
A
V
K
T
V
N
E
-
S
A
S
-
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
-----
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
------
S
LRPEA
E
------
N
-
N
-
P
G
--
R
PPPT-----
L
Q
--
E
--
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
-----
T
V
K
I
G
D
F
G
M
T
R
---
D
-
I
Y
E
T
D
Y
-
Y
-
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
----
L
E
I
V
N
L
L
K
-------
287
Blastp_CBE
43.66
44%
-37
- C3 -
-
4PPB
2
ITK_HUMAN
A:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
-----------
E
D
-
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
529
Blastp_CBE
43.24
40%
24
- C3 -
-
1I44
1
A:
[10-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
S
R
E
K
I
--------
T
-
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
-
N
------
A
R
DIIKG
E
-----
A
--
E
----
T
---
R
V
A
V
K
T
V
N
E
-
S
A
S
-
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
-
K
G
-
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
------
S
LRPEA
E
------
N
-
N
-
P
G
--
R
PPPT-----
L
Q
--
E
--
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
-----
T
V
K
I
G
D
F
G
M
T
----------------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
----
L
E
I
V
N
L
L
K
-------
285
Blastp_CBE
42.32
44%
-43
- C3 -
-
4PPC
2
ITK_HUMAN
A:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
---------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
284
Blastp_CBE
41.49
44%
-44
- C3 -
-
4PPC
2
B:
[3-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
D
P
S
E
L
--------
T
-
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
-
Y
W-----
L
N
-----
K
-----
D
--
K
---------
V
A
I
K
T
I
---------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
----
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
------
T
-----
Q
------
R
-
G
-
L
F
--
A
---------
A
E
--
T
--
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
Q
-----
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
----
S
R
L
L
R
Q
L
A
E
I
-----
468
Blastp_CBE
41.25
40%
-8
- C3 -
-
2J0L
1
A:
[7-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
R
E
R
I
--------
E
-
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
------
M
S
-----
P
-----
E
--
N
PA--
M
---
A
V
A
I
K
T
C
K
N
-
C
T
S
-
D
S
V
R
E
K
-
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
-
E
--
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
------
V
-----
R
------
K
-
F
-
S
L
--
D
---------
L
A
--
S
--
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
-----
C
V
K
L
G
D
F
G
L
S
R
---
Y
-
M
E
D
S
T
K
-
A
-
S
K
G
K
L
---
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------