@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : FGFR1_HUMAN: (2020-09-09 )
MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
Atome Classification :
(448 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......-470........480.......490.......500.......510.....-..520.......530.......540.......550-.-.-----.....560.......570..----------.....580...-....--.590-..----.---....600.......610.......620.......630---.......640.......650.......660.......670.......680.......690....-...700.....-.-.710.....-------...720.......730.......740.......750......-.760.......770.......780.......790.......800.......810.......820
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MW
S
W
K
C
L
L
F
W
A
V
L
V
T
A
T
L
CTARPSPTLPEQAQPWGAP
V
E
V
E
S
FLVHP
G
D
L
L
Q
L
R
C
R
L
R
D
D
V
Q
S
I
N
W
L
R
D
G
V
Q
L
AESNRTRITG
E
E
V
E
V
QDSVPADS
G
L
Y
A
C
VTSSPSGSD
T
T
Y
F
S
V
NVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWT
S
P
E
K
M
E
K
K
L
HAVPAA
K
T
V
K
F
KCPSSGTPN
P
T
L
R
W
L
KNGKEFKPDHRIG
G
Y
K
V
R
Y
A
T
W
S
I
I
M
D
SVVPSDKG
N
Y
T
C
I
V
ENEYGSI
N
H
T
Y
Q
L
D
V
VERSPHR
P
I
L
QAGLPAN
K
T
V
ALGSN
V
E
F
M
C
K
VYSDP
Q
P
H
I
Q
W
L
K
H
IEVNGSKIGPDNL
P
Y
V
Q
I
L
K
TAGVNTTDK
E
M
E
V
L
H
L
RNVSFEDAG
E
Y
T
C
LAGNSIGL
S
H
H
S
A
W
L
T
V
L
E
A
L
E
ERPAVMTS
P
L
Y
L
E
I
I
I
YC
T
G
A
F
L
I
S
C
M
V
G
S
V
I
V
Y
K
MKSGTKK
S
D
F
H
S
Q
M
A
V
H
K
L
A
K
SIPL
R
R
Q
V
T
VSADSSASMNS
G
V
L
L
V
RPSRLSSSGT
P
M
L
AGVSEYELPEDP-R-WELPRD
R
L
V
LGKPLGEGC
F
G
Q
V
V
L
A
E
AIGLDKDKP
N
R
V
T
K
V
A
V
K
M
L
K-SDA
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
GK
H
K
N
I
I
N
L
L
G
A
CT-Q-D-----G
P
L
Y
V
I
V
E
YASKG
N
L
R
E
Y
L
Q
----------ARRPPG-LEYC-YNPS--H
N
P
E
-
E
Q----L---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
AAR
N
V
L
VT---ED
N
V
M
K
I
A
D
FGL
A
R
D
I
H
H
I
D
Y
Y
K
KTTNGRL
P
V
K
WM
A
P
E
A
L
F
D
R
I
Y
THQ
S
D
V
W
S
F
G
V
L
L
W
E
I
F
TL-GGSPYPGV
P
V
E
-
E
-
L
F
-
K
L
L
KEG-------HRMDKPSN
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
AVPSQR
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
LTSNQ
E
Y
L
DLSM
P
L
D
QYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRH
P
A
Q
L
ANGGLKRR
19
PsiBlast_PDB
95.57
99%
-124
- C6 -
-
3KY2
-
FGFR1_HUMAN
A:
[9-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
G
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
-
L
E
Y
S
-
Y
N
P
S
--
H
N
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
----------------------------------------------------------
56
Blastp_CBE
94.53
99%
-123
- C6 -
-
4RWJ
1
FGFR1_HUMAN
A:
[9-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
G
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
-
L
E
Y
S
-
Y
N
P
S
--
H
N
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
----------------------------------------------------------
105
Blastp_CBE
94.46
99%
-128
- C6 -
-
5VND
9
B:
[4-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
---------------
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
95
Blastp_CBE
94.44
99%
-116
- C6 -
-
4RWK
1
FGFR1_HUMAN
A:
[9-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
G
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
-
L
E
Y
S
-
Y
N
P
S
--
H
N
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
----------------------------------------------------------
10
PsiBlast_PDB
94.44
99%
-127
- C6 -
-
5AM6
1
FGFR1_HUMAN
A:
[2-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
G
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
---------------
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
3
PsiBlast_PDB
94.06
97%
-130
- C6 -
-
3GQI
2
A:
[16-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
-
L
E
F
S
-
F
N
P
S
--
H
N
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
Y
L
D
L
S
----------------------------------------------------
53
Blastp_CBE
93.96
99%
-122
- C6 -
-
4UWB
4
FGFR1_HUMAN
A:
[8-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
-
L
E
Y
S
---
P
S
--
H
N
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
-
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
14
PsiBlast_PDB
93.87
98%
-128
- C6 -
-
5AM7
1
FGFR1_HUMAN
A:
[3-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
--------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
----------------------------------------------------------
4
PsiBlast_PDB
93.79
99%
-119
- C6 -
-
3TT0
1
FGFR1_HUMAN
A:
[54-358]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
-
L
E
Y
S
-
Y
N
P
S
--
H
N
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
39
Blastp_CBE
93.56
99%
-137
- C6 -
-
5O4A
2
FGFR1_HUMAN
A:
[8-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
---------------
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
----------------------------------------------------------
51
Blastp_CBE
93.54
99%
-119
- C6 -
-
4UWC
10
FGFR1_HUMAN
A:
[9-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
-
L
E
Y
S
-
Y
-
P
S
--
H
N
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
18
PsiBlast_PDB
93.46
99%
-123
- C6 -
-
3JS2
1
FGFR1_HUMAN
A:
[16-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
-
L
----------
H
N
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
43
Blastp_CBE
93.39
99%
-130
- C6 -
-
5EW8
1
FGFR1_HUMAN
A:
[8-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
---------------
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
35
Blastp_CBE
93.02
99%
-127
- C6 -
-
6ITJ
1
?
B:
[2-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
-
L
E
Y
S
-
Y
-------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
-----
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
-------------------------------------------------------------
106
Blastp_CBE
92.97
99%
-120
- C6 -
-
5VND
10
FGFR1_HUMAN
A:
[7-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
-
L
E
Y
S
-
Y
N
P
S
--
H
N
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
-
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
38
Blastp_CBE
92.94
99%
-132
- C6 -
-
5O4A
1
B:
[4-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
--
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
-
L
E
Y
S
-
Y
--------
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
-----------------------------------------------------------
50
Blastp_CBE
92.65
99%
-121
- C6 -
-
4UWC
9
B:
[3-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
--
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
-
L
E
Y
S
-
Y
-----
H
N
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
----------------------------------------------------------
110
Blastp_CBE
92.51
99%
-134
- C6 -
-
3C4F
1
FGFR1_HUMAN
A:
[1-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
----------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
580
HHSearch
92.28
99%
-122
- C6 -
-
3TT0
1
FGFR1_HUMAN
A:
[58-355]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
-
L
E
Y
S
-
Y
N
P
S
--
H
N
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
------------------------------------------------------------
104
Blastp_CBE
92.24
99%
-134
- C6 -
-
5ZV2
1
FGFR1_HUMAN
A:
[4-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
-------------------
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
--
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
------------------------------------------------------------
47
Blastp_CBE
92.21
99%
-127
- C6 -
-
4V04
7
FGFR1_HUMAN
A:
[7-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
-
L
E
Y
S
---
P
S
--
H
N
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
--------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
45
Blastp_CBE
92.19
99%
-130
- C6 -
-
4V05
4
FGFR1_HUMAN
A:
[8-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
---------------
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
17
PsiBlast_PDB
92.19
99%
-130
- C6 -
-
6ITJ
1
?
A:
[8-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
----------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
108
Blastp_CBE
92.17
99%
-134
- C6 -
-
3RHX
5
FGFR1_HUMAN
A:
[5-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
----------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
----------------------------------------------------------
97
Blastp_CBE
91.98
99%
-122
- C6 -
-
5A4C
6
FGFR1_HUMAN
A:
[6-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
--
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
-
L
E
Y
S
-
Y
N
P
S
--
H
N
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
577
HHSearch
91.88
100%
-120
- C6 -
-
5A46
2
B:
[22-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
L
--
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
-------------
H
N
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
42
Blastp_CBE
91.89
99%
-125
- C6 -
-
5EW8
1
B:
[5-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
------------------
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
--
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
21
Blastp_CBE
91.88
100%
-120
- C6 -
-
5A46
2
B:
[22-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
L
--
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
-------------
H
N
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
15
PsiBlast_PDB
91.85
99%
-130
- C6 -
-
4ZSA
1
FGFR1_HUMAN
A:
[8-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
----------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
46
Blastp_CBE
91.72
99%
-128
- C6 -
-
4V04
6
B:
[2-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
------------------
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
--------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
55
Blastp_CBE
91.71
99%
-134
- C6 -
-
4RWJ
1
B:
[11-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
---------
Y
K
K
T
T
-
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
-----------------------------------------------------------
34
Blastp_CBE
91.71
99%
-128
- C6 -
-
5AM7
1
B:
[3-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
--------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-----
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
------------------------------------------------------------
59
Blastp_CBE
91.67
99%
-131
- C6 -
-
4NKA
2
B:
[2-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
--
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
------------------
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
------
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
1
PsiBlast_PDB
91.62
100%
-130
- C6 -
-
5A46
4
FGFR1_HUMAN
A:
[28-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
-
L
-------------
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
---
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
70
Blastp_CBE
91.55
99%
-125
- C6 -
-
3JS2
1
B:
[11-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
------------------
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
------------------------------------------------------------
109
Blastp_CBE
91.42
99%
-127
- C6 -
-
3C4F
1
B:
[1-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
----------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
52
Blastp_CBE
91.41
99%
-116
- C6 -
-
4UWB
3
B:
[3-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
--
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
-
L
E
Y
S
-
Y
-----
H
N
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
41
Blastp_CBE
91.39
99%
-133
- C6 -
-
5O49
1
FGFR1_HUMAN
A:
[8-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
----------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
----------------------------------------------------------
98
Blastp_CBE
91.29
99%
-128
- C6 -
-
6P69
2
B:
[5-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
----
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
----------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
------------------------------------------------------------
36
Blastp_CBE
91.28
99%
-137
- C6 -
-
5Z0S
1
B:
[7-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
----
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
----------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
-
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
-------------------------------------------------------------
6
PsiBlast_PDB
91.28
99%
-136
- C6 -
-
1FGI
1
FGFR1_HUMAN
A:
[9-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
----
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
----------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
------------------------------------------------------------
16
PsiBlast_PDB
91.26
99%
-137
- C6 -
-
5Z0S
1
FGFR1_HUMAN
A:
[7-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
--
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
----------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
------------------------------------------------------------
102
Blastp_CBE
91.12
99%
-136
- C6 -
-
6P68
1
FGFR1_HUMAN
A:
[6-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
----------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
---
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
-----------------------------------------------------------
101
Blastp_CBE
91.09
99%
-136
- C6 -
-
6P68
1
FGFR1_HUMAN
B:
[6-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
-----------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
---
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
-----------------------------------------------------------
581
HHSearch
91.07
99%
-133
- C6 -
-
5EW8
1
B:
[6-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
------------------
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
--
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
--------------------------------------------------------------
44
Blastp_CBE
91.06
99%
-128
- C6 -
-
4V05
3
B:
[3-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
---
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
------------------
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
----
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
----------------------------------------------------------
37
Blastp_CBE
91.02
99%
-136
- C6 -
-
4ZSA
1
B:
[5-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
----------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
-------------------------------------------------------------
54
Blastp_CBE
91.00
99%
-127
- C6 -
-
4RWL
1
B:
[10-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
---
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
------------------
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
----------------------------------------------------------
61
Blastp_CBE
90.98
99%
-131
- C6 -
-
4NK9
2
B:
[4-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
--
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
-------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
--------
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
40
Blastp_CBE
90.98
99%
-131
- C6 -
-
5O49
1
B:
[4-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
---
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
-----------------
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
13
PsiBlast_PDB
90.86
99%
-133
- C6 -
-
6NVL
1
FGFR1_HUMAN
A:
[7-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
-------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--------
Y
Y
K
K
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
62
Blastp_CBE
90.73
99%
-135
- C6 -
-
4NK9
5
FGFR1_HUMAN
A:
[8-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
-
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
------------------
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
-------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
103
Blastp_CBE
90.65
99%
-137
- C6 -
-
5ZV2
1
B:
[2-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
-----------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-------
D
Y
Y
K
K
T
---
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
----------------------------------------------------------
159
Blastp_CBE
90.55
84%
-123
- C6 -
-
5EG3
1
A:
[22-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
G
---------
N
--
R
V
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
F
F
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
T
N
E
E
-
L
D
L
S
Q
P
--------------------------------------------------
122
Blastp_CBE
90.47
87%
-127
- C6 -
-
4J98
1
FGFR2_HUMAN
B:
[17-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
G
-
M
E
Y
S
-
Y
D
I
N
--
R
V
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
Q
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
60
Blastp_CBE
90.35
99%
-133
- C6 -
-
4NKA
3
FGFR1_HUMAN
A:
[8-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
----
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
----------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
-------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
26
Blastp_CBE
90.35
99%
-138
- C6 -
-
5B7V
1
B:
[7-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
D
--
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
-----------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-----
D
Y
Y
K
K
T
T
-
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
------------------------------------------------------------
100
Blastp_CBE
90.33
99%
-133
- C6 -
-
6P68
1
C:
[7-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
----------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
---
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
-----------------------------------------------------------
11
PsiBlast_PDB
90.32
99%
-131
- C6 -
-
5B7V
1
FGFR1_HUMAN
A:
[9-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
----
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
---------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
-----------------------------------------------------------
99
Blastp_CBE
90.19
99%
-123
- C6 -
-
6P69
3
FGFR1_HUMAN
A:
[6-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
----
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
----------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
96
Blastp_CBE
90.08
99%
-123
- C6 -
-
5A4C
7
B:
[1-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
---
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
------------------
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
-----
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
2
PsiBlast_PDB
90.06
99%
-120
- C6 -
-
3GQL
1
FGFR1_HUMAN
A:
[15-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
------------------
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
------------
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
Y
L
D
L
S
M
P
L
D
------------------------------------------------
155
Blastp_CBE
89.96
86%
-126
- C6 -
-
5UI0
1
B:
[18-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
G
-
M
E
Y
S
-
Y
D
I
N
--
R
V
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
M
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
T
------------------------------------------------------------
66
Blastp_CBE
89.95
99%
-142
- C6 -
-
4F64
3
FGFR1_HUMAN
A:
[8-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
----
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
----------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
------------------------------------------------------------
7
PsiBlast_PDB
89.95
99%
-138
- C6 -
-
1AGW
1
FGFR1_HUMAN
A:
[9-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
----
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
----------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
------------------------------------------------------------
8
PsiBlast_PDB
89.85
99%
-141
- C6 -
-
2FGI
1
FGFR1_HUMAN
A:
[9-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
----
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
-------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
-
D
I
H
H
I
D
Y
Y
K
K
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
------------------------------------------------------------
147
Blastp_CBE
89.84
87%
-122
- C6 -
-
4J96
1
FGFR2_HUMAN
B:
[18-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
G
-
M
E
Y
S
-
Y
D
I
N
--
R
V
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
M
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
T
N
-----------------------------------------------------------
94
Blastp_CBE
89.70
99%
-129
- C6 -
-
4RWK
1
B:
[11-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
---------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
-----
I
D
Y
Y
K
K
T
--
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
-----------------------------------------------------------
64
Blastp_CBE
89.47
99%
-136
- C6 -
-
4F65
6
FGFR1_HUMAN
A:
[8-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
--
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
---------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
----------
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
49
Blastp_CBE
89.43
99%
-135
- C6 -
-
4V01
7
FGFR1_HUMAN
A:
[9-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
----
G
Q
V
V
L
A
E
A
I
G
L
--
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
-------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
--------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
22
Blastp_CBE
89.30
99%
-137
- C6 -
-
3GQL
1
C:
[15-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
------------------
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
Y
--------------------------------------------------------
68
Blastp_CBE
89.23
99%
-139
- C6 -
-
4F63
3
FGFR1_HUMAN
A:
[8-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
----
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
----------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
------------------------------------------------------------
74
Blastp_CBE
89.09
99%
-126
- C6 -
-
6C1O
1
FGFR1_HUMAN
A:
[10-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
-------
Y
N
P
S
--
H
N
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
63
Blastp_CBE
89.06
99%
-133
- C6 -
-
4F65
4
B:
[4-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
---
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
--------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
-------
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
-----------------------------------------------------------
162
Blastp_CBE
88.98
83%
-128
- C6 -
-
4K33
1
A:
[25-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
A
D
P
-
K
-
W
E
L
S
R
A
R
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
I
G
I
D
K
D
R
A
A
K
P
V
T
V
A
V
K
M
L
K
-
D
D
A
T
D
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
G
-----
G
P
L
Y
V
L
V
E
Y
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
P
G
-
L
D
Y
S
-
F
D
T
S
-------
E
Q
----
L
---
T
F
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
V
H
N
L
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
H
D
L
Y
M
I
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
V
L
-
T
V
T
-------------------------------------------------------------
27
Blastp_CBE
88.94
99%
-134
- C6 -
-
5AM6
1
B:
[3-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
----------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
------------------------------------------------------------
80
Blastp_CBE
88.84
99%
-133
- C6 -
-
6C19
1
FGFR1_HUMAN
A:
[10-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
----
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
---
E
Y
S
-
Y
N
P
S
-----
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
72
Blastp_CBE
88.83
99%
-133
- C6 -
-
6MZQ
1
FGFR1_HUMAN
A:
[10-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
-
L
E
Y
S
-
Y
N
P
S
-----
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
-
Q
E
---------------------------------------------------------
82
Blastp_CBE
88.82
99%
-128
- C6 -
-
6C18
1
FGFR1_HUMAN
A:
[11-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
----
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
----
S
-
Y
N
P
S
--
H
N
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
76
Blastp_CBE
88.80
99%
-128
- C6 -
-
6C1C
1
FGFR1_HUMAN
A:
[11-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
-----
S
-
Y
N
P
S
--
H
N
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
143
Blastp_CBE
88.78
87%
-131
- C6 -
-
4J99
1
B:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
G
-
M
E
Y
S
-
Y
D
----------
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
T
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
84
Blastp_CBE
88.75
99%
-130
- C6 -
-
5UR1
1
FGFR1_HUMAN
A:
[10-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
-
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
-------
Y
N
P
S
--
H
N
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
29
Blastp_CBE
88.72
99%
-141
- C6 -
-
1FGI
1
B:
[6-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
----
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
---------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
-------------------------------------------------------------
142
Blastp_CBE
88.65
87%
-131
- C6 -
-
4J99
1
?
C:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
G
-
M
E
Y
S
-
Y
D
----------
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
T
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
180
Blastp_CBE
88.66
74%
-135
- C6 -
-
4QRC
1
A:
[24-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
P
-
L
-
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-----
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
P
G
-
P
D
L
S
-
P
D
G
P
--
R
S
S
E
-
G
P
----
L
---
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
-
L
A
V
-------------------------------------------------------------
48
Blastp_CBE
88.65
99%
-133
- C6 -
-
4V01
6
B:
[5-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
V
L
A
E
A
I
G
L
D
---
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
--------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
--------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
-----------------------------------------------------------
30
Blastp_CBE
88.65
99%
-139
- C6 -
-
1AGW
1
B:
[6-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
----
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
---------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
-------------------------------------------------------------
92
Blastp_CBE
88.55
99%
-143
- C6 -
-
4WUN
1
B:
[7-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
-------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
------------------------------------------------------------
23
Blastp_CBE
88.47
99%
-132
- C6 -
-
3GQL
1
FGFR1_HUMAN
B:
[15-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
---------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
93
Blastp_CBE
88.38
99%
-128
- C6 -
-
4WUN
1
FGFR1_HUMAN
A:
[11-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
--
L
E
Y
S
-
Y
N
P
S
--
H
N
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
12
PsiBlast_PDB
88.38
99%
-128
- C6 -
-
6MZW
1
FGFR1_HUMAN
A:
[10-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
-
L
E
Y
S
-
Y
N
P
S
----
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
118
Blastp_CBE
88.31
87%
-125
- C6 -
-
3B2T
1
B:
[1-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
L
A
G
V
S
E
Y
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
----
F
G
Q
V
V
M
A
E
A
V
G
I
--
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
-------------------
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
177
Blastp_CBE
88.29
74%
-135
- C6 -
-
6JPJ
1
A:
[12-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
P
-
L
-
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-----
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
P
G
-
P
D
L
S
-
P
D
G
P
--
R
S
S
E
-
G
P
----
L
---
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
-
L
A
V
S
E
-----------------------------------------------------------
161
Blastp_CBE
88.22
86%
-122
- C6 -
-
5UGX
1
FGFR2_HUMAN
A:
[24-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
G
-
M
E
Y
S
-
Y
D
I
N
--
R
V
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
V
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
124
Blastp_CBE
88.15
86%
-127
- C6 -
-
2PVF
1
A:
[23-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
---
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
G
-
M
E
Y
S
-
Y
-----------
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
T
------------------------------------------------------------
139
Blastp_CBE
88.10
87%
-131
- C6 -
-
2PVY
1
?
B:
[18-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
G
-------
D
I
N
--
R
V
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
--
Y
Y
K
----
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
78
Blastp_CBE
88.07
99%
-143
- C6 -
-
6C1B
1
FGFR1_HUMAN
A:
[11-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
-----------------
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
154
Blastp_CBE
87.93
87%
-135
- C6 -
-
5UGL
1
A:
[24-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
----------------
R
V
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
V
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
83
Blastp_CBE
87.90
99%
-146
- C6 -
-
5UR1
1
B:
[10-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
--
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
--------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
-----------------------------------------------------------
65
Blastp_CBE
87.85
99%
-136
- C6 -
-
4F64
3
B:
[5-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
----
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
---------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
-------------------------------------------------------------
57
Blastp_CBE
87.73
99%
-134
- C6 -
-
4NKS
1
B:
[5-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
-
G
Q
V
V
L
A
E
A
I
G
L
----
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
---------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
-------------------------------------------------------------
107
Blastp_CBE
87.72
99%
-130
- C6 -
-
3RHX
3
B:
[2-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
----
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
---------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
-------------------------------------------------------------
183
Blastp_CBE
87.64
74%
-137
- C6 -
-
4UXQ
1
A:
[8-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
L
P
L
D
P
-
L
-
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-----
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
P
------------------
G
P
----
L
---
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
-
L
A
V
-------------------------------------------------------------
75
Blastp_CBE
87.56
99%
-146
- C6 -
-
6C1C
1
B:
[9-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
-
F
G
Q
V
V
L
A
E
A
I
G
L
--
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
--------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
-----------------------------------------------------------
151
Blastp_CBE
87.52
87%
-126
- C6 -
-
2PWL
1
FGFR2_HUMAN
B:
[24-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
G
-----------------
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
T
------------------------------------------------------------
119
Blastp_CBE
87.50
87%
-124
- C6 -
-
3B2T
1
FGFR2_HUMAN
A:
[7-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
---
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
-------------------
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
T
N
Q
E
---------------------------------------------------------
32
Blastp_CBE
87.44
99%
-149
- C6 -
-
6NVL
1
FGFR1_HUMAN
C:
[9-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
D
---
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
--
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
----
H
H
I
D
Y
Y
K
K
T
-----
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
-------------------------------------------------------------
67
Blastp_CBE
87.38
99%
-135
- C6 -
-
4F63
3
B:
[5-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
-
G
Q
V
V
L
A
E
A
I
G
L
----
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
---------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
-------------------------------------------------------------
114
Blastp_CBE
87.33
87%
-133
- C6 -
-
3RI1
1
?
A:
[13-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
------------------
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
T
------------------------------------------------------------
71
Blastp_CBE
87.33
99%
-149
- C6 -
-
6MZQ
1
B:
[8-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
---------------------------
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
-------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
-------------------------------------------------------------
127
Blastp_CBE
87.24
87%
-126
- C6 -
-
4J97
1
B:
[24-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
---
G
Q
V
V
M
A
E
A
V
G
I
D
-----
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
G
--------
I
N
--
R
V
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
136
Blastp_CBE
87.22
87%
-133
- C6 -
-
2PZP
1
FGFR2_HUMAN
A:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
E
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
-----------------
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
T
N
-----------------------------------------------------------
125
Blastp_CBE
87.21
87%
-127
- C6 -
-
4J97
1
?
D:
[22-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
-----
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
-------------
R
V
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
140
Blastp_CBE
87.20
87%
-129
- C6 -
-
2PVY
1
?
A:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
G
-
M
-----
D
I
N
--
R
V
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
58
Blastp_CBE
87.15
99%
-140
- C6 -
-
4NKS
1
FGFR1_HUMAN
A:
[9-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
-------
N
R
V
T
K
V
A
V
K
M
L
K
--
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
-------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
------------------------------------------------------------
86
Blastp_CBE
87.07
99%
-144
- C6 -
-
5UQ0
1
FGFR1_HUMAN
A:
[10-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
--
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
--
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
-------------------
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
--
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
---------------------------------------------------------
24
Blastp_CBE
87.01
99%
-135
- C6 -
-
3TT0
4
B:
[52-356]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
---------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
-----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
-----------------------------------------------------------
150
Blastp_CBE
86.99
87%
-130
- C6 -
-
2PY3
1
FGFR2_HUMAN
A:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
----
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
-----------------
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
T
N
-----------------------------------------------------------
138
Blastp_CBE
86.99
87%
-133
- C6 -
-
2PVY
1
?
C:
[18-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
G
-
M
E
----------
V
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
--
Y
Y
K
---
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
28
Blastp_CBE
86.92
99%
-131
- C6 -
-
2FGI
1
B:
[6-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
----
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
---------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
-------------------------------------------------------------
135
Blastp_CBE
86.91
87%
-129
- C6 -
-
2PZP
1
B:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
E
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
G
---------------
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
T
N
-----------------------------------------------------------
152
Blastp_CBE
86.88
87%
-122
- C6 -
-
2PWL
1
FGFR2_HUMAN
A:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
-------------------
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
149
Blastp_CBE
86.77
87%
-128
- C6 -
-
2PY3
1
B:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
----
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
G
---------------
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
T
N
-----------------------------------------------------------
33
Blastp_CBE
86.74
99%
-149
- C6 -
-
6NVL
1
FGFR1_HUMAN
B:
[5-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
-------
Q
V
V
L
A
E
A
I
G
L
--
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
-
L
---------------
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
-------------------------------------------------------------
178
Blastp_CBE
86.70
74%
-138
- C6 -
-
6IUP
2
?
A:
[21-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
L
P
L
D
P
-
L
-
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
---
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-----
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
-----------
P
--
R
S
S
E
-
G
P
----
L
---
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
-
L
A
V
-------------------------------------------------------------
126
Blastp_CBE
86.68
87%
-125
- C6 -
-
4J97
1
?
C:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
---
F
G
Q
V
V
M
A
E
A
V
G
I
D
-----
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
---------
I
N
--
R
V
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
25
Blastp_CBE
86.58
99%
-152
- C6 -
-
6MZW
1
B:
[9-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
--
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
--------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
--------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
------------------------------------------------------------
160
Blastp_CBE
86.56
86%
-130
- C6 -
-
5UGX
1
B:
[24-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
G
-
M
------
I
N
--
R
V
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
V
----------
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
193
Blastp_CBE
86.44
76%
-134
- C6 -
-
4XCU
1
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
P
-
L
-
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-----
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
P
G
-------------
S
S
E
-
G
P
----
L
---
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
-
L
A
V
S
------------------------------------------------------------
137
Blastp_CBE
86.44
87%
-134
- C6 -
-
2PVY
1
?
D:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
G
-------------
V
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
131
Blastp_CBE
86.44
87%
-129
- C6 -
-
4J95
1
?
B:
[24-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
--------------------
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
141
Blastp_CBE
86.42
87%
-132
- C6 -
-
4J99
1
?
D:
[21-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
---------------------
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
T
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
132
Blastp_CBE
86.41
87%
-132
- C6 -
-
4J95
1
FGFR2_HUMAN
A:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
--------------------
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
----
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
31
Blastp_CBE
86.36
99%
-138
- C6 -
-
6NVL
1
D:
[15-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
--------
Q
V
V
L
A
E
A
I
G
L
--
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
--
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
---------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
P
G
-
L
E
Y
S
-
Y
N
P
S
--
H
N
P
E
-
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
---------
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
------------------------------------------------------------
134
Blastp_CBE
86.33
87%
-137
- C6 -
-
2Q0B
1
FGFR2_HUMAN
A:
[24-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
-----
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
-----------------
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
T
------------------------------------------------------------
145
Blastp_CBE
86.24
87%
-133
- C6 -
-
2PZ5
1
B:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
T
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
------------------
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
T
N
-----------------------------------------------------------
146
Blastp_CBE
86.12
87%
-133
- C6 -
-
2PZ5
1
FGFR2_HUMAN
A:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
T
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
-----------------
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
T
N
-----------------------------------------------------------
73
Blastp_CBE
86.00
99%
-140
- C6 -
-
6C1O
1
B:
[10-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
--
F
G
Q
V
V
L
A
E
A
I
G
L
---
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
P
--------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
-----------------------------------------------------------
120
Blastp_CBE
85.93
87%
-133
- C6 -
-
2PZR
1
B:
[23-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
----------------
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
R
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
T
N
-----------------------------------------------------------
128
Blastp_CBE
85.91
87%
-128
- C6 -
-
4J97
1
FGFR2_HUMAN
A:
[24-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
---
G
Q
V
V
M
A
E
A
V
G
I
--
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
G
--------------
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
133
Blastp_CBE
85.90
87%
-135
- C6 -
-
2Q0B
1
B:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
-----
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
----------------
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
T
N
-----------------------------------------------------------
115
Blastp_CBE
85.89
86%
-125
- C6 -
-
3CLY
1
FGFR2_HUMAN
A:
[24-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
------------------
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
T
N
E
E
Y
L
D
L
-----------------------------------------------------
121
Blastp_CBE
85.85
87%
-135
- C6 -
-
2PZR
1
FGFR2_HUMAN
A:
[24-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
----------------
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
R
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
T
------------------------------------------------------------
184
Blastp_CBE
85.84
75%
-158
- C6 -
-
5NWZ
1
B:
[8-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
P
-
L
-
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-----
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
P
-------------------
P
----
L
---
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
-----------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
-
L
A
V
S
E
-----------------------------------------------------------
583
HHSearch
85.79
87%
-113
- C6 -
-
6AGX
1
?
D:
[3-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
G
-
M
E
Y
S
-
Y
D
I
N
--
R
V
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
---------------------------------------------------------------
130
Blastp_CBE
85.73
87%
-128
- C6 -
-
4J95
1
?
C:
[24-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
---------------------
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
113
Blastp_CBE
85.63
87%
-132
- C6 -
-
3RI1
1
FGFR2_HUMAN
B:
[13-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
---
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
------------------
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
T
N
-----------------------------------------------------------
158
Blastp_CBE
85.62
86%
-130
- C6 -
-
5UHN
1
FGFR2_HUMAN
A:
[25-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
------------------
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
187
Blastp_CBE
85.57
75%
-156
- C6 -
-
5NUD
1
FGFR4_HUMAN
A:
[7-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
P
-
L
-
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-----
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
--------------------
P
----
L
---
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
-----------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
-
L
A
V
S
E
E
----------------------------------------------------------
144
Blastp_CBE
85.56
87%
-135
- C6 -
-
4J99
1
FGFR2_HUMAN
A:
[22-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
--------------------
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
--
D
Y
Y
K
--
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
79
Blastp_CBE
85.55
99%
-138
- C6 -
-
6C19
1
B:
[10-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
--------------------
E
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
------------------------------------------------------------
185
Blastp_CBE
85.36
75%
-155
- C6 -
-
5NWZ
1
FGFR4_HUMAN
A:
[8-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
P
-
L
-
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-----
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
P
G
-
P
D
L
--------------
P
----
L
---
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
-
L
A
V
S
E
-----------------------------------------------------------
179
Blastp_CBE
85.26
74%
-156
- C6 -
-
6IUO
1
?
A:
[14-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
A
G
L
V
S
L
D
L
P
L
D
P
-
L
-
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
--
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-----
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
P
------------------
G
P
----
L
---
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
-
L
A
V
-------------------------------------------------------------
153
Blastp_CBE
85.17
87%
-142
- C6 -
-
5UGL
1
?
B:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
-------------------------
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
V
I
-----------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
189
Blastp_CBE
85.11
76%
-146
- C6 -
-
6NVJ
1
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
P
-
L
-
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-----
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
P
G
-------------
S
S
E
-
G
P
----
L
---
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
-
L
A
V
S
------------------------------------------------------------
77
Blastp_CBE
85.11
99%
-149
- C6 -
-
6C1B
1
B:
[9-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
--------
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
---------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
------------------------------------------------------------
186
Blastp_CBE
85.08
75%
-160
- C6 -
-
5NUD
1
B:
[7-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
P
-
L
-
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-----
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
P
-------------------
P
----
L
---
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
------------------
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
-
L
A
V
-------------------------------------------------------------
191
Blastp_CBE
85.04
76%
-147
- C6 -
-
6NVH
1
A:
[5-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
P
-
L
-
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-----
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
P
G
-------------
S
S
E
-
G
P
----
L
---
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
---------------
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
-
L
A
V
-------------------------------------------------------------
81
Blastp_CBE
84.83
99%
-144
- C6 -
-
6C18
1
B:
[12-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
----
G
Q
V
V
L
A
E
A
I
G
L
--
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
---------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
--------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
------------------------------------------------------------
129
Blastp_CBE
84.79
87%
-137
- C6 -
-
4J95
2
?
D:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
---------------------
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
-----------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
192
Blastp_CBE
84.75
76%
-149
- C6 -
-
6NVG
1
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
P
-
L
-
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-----
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
P
G
-------------
S
S
E
-
G
P
----
L
---
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
-
L
A
V
S
------------------------------------------------------------
171
Blastp_CBE
84.65
74%
-143
- C6 -
-
4TYJ
2
A:
[5-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
L
V
S
L
D
L
P
L
D
P
-
L
-
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-----
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
--------------------
P
----
L
---
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
---------------
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
-
L
A
V
S
E
E
----------------------------------------------------------
116
Blastp_CBE
84.60
88%
-124
- C6 -
-
1OEC
1
A:
[15-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
---
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
--------------------
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
85
Blastp_CBE
84.01
99%
-147
- C6 -
-
5UQ0
1
B:
[9-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
P
-
R
-
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
------
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
----------
A
R
R
---------------------
Q
----
L
---
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
--
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
-
A
L
T
S
------------------------------------------------------------
175
Blastp_CBE
83.94
74%
-150
- C6 -
-
4R6V
1
A:
[14-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
L
A
G
L
V
S
L
D
L
P
L
D
P
-
L
-
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
-----
D
Q
A
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-----
G
P
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
P
------------------
G
P
----
L
---
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
-----------------
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
-
L
A
V
-------------------------------------------------------------
167
Blastp_CBE
83.91
74%
-151
- C6 -
-
4QQC
1
A:
[14-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
L
A
G
L
V
S
L
D
L
P
L
D
P
-
L
-
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
-----
D
Q
A
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-----
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
P
------------------
G
P
----
L
---
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
-
L
A
V
-------------------------------------------------------------
188
Blastp_CBE
83.82
76%
-148
- C6 -
-
6NVK
1
A:
[5-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
P
-
L
-
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-----
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
P
G
-------------
S
S
E
-
G
P
----
L
---
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
-
L
A
V
-------------------------------------------------------------
176
Blastp_CBE
83.77
74%
-149
- C6 -
-
4QQ5
1
A:
[14-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
L
A
G
L
V
S
L
D
L
P
L
D
P
-
L
-
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
-----
D
Q
A
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-----
G
P
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
P
------------------
G
P
----
L
---
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
-
L
A
V
-------------------------------------------------------------
170
Blastp_CBE
83.72
74%
-154
- C6 -
-
5XFF
1
A:
[11-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
P
-
L
-
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-----
G
P
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
P
G
-
P
----------------
P
----
L
---
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
-
L
A
V
-------------------------------------------------------------
190
Blastp_CBE
83.38
76%
-147
- C6 -
-
6NVI
1
A:
[5-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
P
-
L
-
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
----
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-----
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
P
---------------
S
E
-
G
P
----
L
---
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
-------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
-
L
A
V
-------------------------------------------------------------
172
Blastp_CBE
83.09
74%
-133
- C6 -
-
4TYI
1
A:
[5-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
L
V
S
L
D
L
P
L
D
P
-
L
-
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-----
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
P
-------------------
P
----
L
---
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
--------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
-
L
A
V
-------------------------------------------------------------
157
Blastp_CBE
83.04
86%
-134
- C6 -
-
5UHN
2
B:
[25-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
---------------------
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
-----------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
169
Blastp_CBE
82.06
74%
-149
- C6 -
-
5XFJ
1
A:
[11-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
P
-
L
-
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
-
D
---
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-----
G
P
L
Y
V
I
M
E
C
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
P
G
-
P
----------------
P
----
L
---
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
-
L
A
V
-------------------------------------------------------------
168
Blastp_CBE
81.38
74%
-141
- C6 -
-
5JKG
1
A:
[11-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
P
-
L
-
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
D
P
A
R
P
D
Q
A
S
T
V
A
V
K
M
L
K
-
D
---
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-----
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
----------
A
R
R
P
P
G
-
P
----------------
P
----
L
---
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
-
L
A
V
-------------------------------------------------------------
590
HHSearch
77.47
56%
-123
- C6 -
-
6FEK
3
A:
[15-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
-
K
-
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
K
G
R
--
A
G
Y
T
T
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-----
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
----------
E
S
R
K
V
G
-
P
----------
G
P
D
E
-
R
A
----
L
---
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
F
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-----------------------------------------------------------------
246
Blastp_CBE
77.33
52%
-121
- C6 -
-
6NEC
2
C:
[2-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
S
L
S
V
D
A
F
K
I
L
E
D
P
-
K
-
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
R
A
G
Y
T
T
-
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-----
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
----------
E
S
R
K
V
----------------
E
-
R
A
----
L
---
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
---------
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-
V
---------------------------------------------------------------
248
Blastp_CBE
76.62
52%
-128
- C6 -
-
2IVS
4
B:
[2-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
S
L
S
V
D
A
F
K
I
---
P
-
K
-
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
R
A
G
Y
T
T
-
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-----
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
----------
E
S
R
K
-------------------
R
A
----
L
---
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
-----------
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-
V
---------------------------------------------------------------
304
Blastp_CBE
76.24
49%
-101
- C6 -
-
1T46
1
?
A:
[11-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
-
K
-
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
--
D
A
A
M
T
V
A
V
K
M
L
K
-
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-----
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
D
S
F
-----------------
L
A
----
L
---
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
-
S
E
S
T
N
-----------------------------------------------------------
309
Blastp_CBE
76.04
49%
-104
- C6 -
-
6ITV
1
?
A:
[29-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
-
K
-
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
--
D
A
A
M
T
V
A
V
K
M
L
K
-
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-----
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
D
S
-------------
E
D
D
E
-
L
A
----
L
---
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
-
S
E
S
T
N
H
----------------------------------------------------------
270
Blastp_CBE
75.58
50%
-97
- C6 -
-
6GQK
1
?
A:
[29-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
-
K
-
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
G
L
I
K
S
--
D
A
A
M
T
V
A
V
K
M
L
K
-
P
S
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
D
E
F
-
V
P
Y
K
-
V
A
P
E
--
D
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
N
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
K
Q
I
-
S
E
S
-------------------------------------------------------------
310
Blastp_CBE
75.45
49%
-107
- C6 -
-
6KLA
1
?
A:
[29-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
-
K
-
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
--
D
A
A
M
T
V
A
V
K
M
L
K
-
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-----
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
D
S
-------------
E
D
D
E
-
L
A
----
L
---
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
-
S
E
S
-------------------------------------------------------------
306
Blastp_CBE
75.38
49%
-100
- C6 -
-
4U0I
1
A:
[13-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
-
K
-
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
-----
A
A
M
T
V
A
V
K
M
L
K
-
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-----
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
D
S
F
-
I
C
S
-------------
L
A
----
L
---
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
-
S
E
S
T
N
-----------------------------------------------------------
249
Blastp_CBE
75.22
52%
-120
- C6 -
-
2IVS
5
RET_HUMAN
A:
[14-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
P
-
K
-
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
R
A
G
Y
T
T
-
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-----
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
----------
E
S
R
K
V
G
-
P
G
Y
L
------------
R
A
----
L
---
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-
V
---------------------------------------------------------------
247
Blastp_CBE
75.08
52%
-115
- C6 -
-
6NEC
3
RET_HUMAN
A:
[14-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
P
-
K
-
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
R
A
G
Y
T
T
-
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-----
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
----------
E
S
R
K
V
G
-
P
G
Y
L
-
G
-------
D
E
-
R
A
----
L
---
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-
V
---------------------------------------------------------------
202
Blastp_CBE
74.99
56%
-115
- C6 -
-
3KRJ
1
A:
[34-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
N
E
-
K
-
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
--
D
A
V
L
K
V
A
V
K
M
L
K
-
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
P
P
G
------------------
Q
----
L
---
S
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
---------------------------------------------------------------------
164
Blastp_CBE
74.91
86%
-81
- C6 -
-
6AGX
1
?
C:
[1-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
---------
N
----
R
V
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
-----
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
315
Blastp_CBE
74.75
49%
-106
- C6 -
-
3G0F
1
?
B:
[34-331]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
-
K
-
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
--
D
A
A
M
T
V
A
V
K
M
L
K
-
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-----
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
D
S
F
-----------------------
L
---
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
H
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
-
S
E
--------------------------------------------------------------
295
Blastp_CBE
74.72
50%
-102
- C6 -
-
6HH1
1
?
A:
[11-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
-
K
-
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
--
D
A
A
M
T
V
A
V
K
M
L
K
-
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-----
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
D
S
F
-
I
--
C
-
S
K
T
S
--
P
A
I
E
-
L
A
----
L
---
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
-
S
---------------------------------------------------------------
266
Blastp_CBE
74.62
50%
-98
- C6 -
-
6GQM
2
A:
[29-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
-
K
-
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
G
L
I
K
S
--
D
A
A
M
T
V
A
V
K
M
L
K
-
P
S
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
D
E
F
-
V
P
Y
---------
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
N
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
K
Q
I
-
S
E
S
-------------------------------------------------------------
285
Blastp_CBE
74.59
49%
-105
- C6 -
-
5GRN
1
A:
[39-341]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
R
-
W
E
F
P
R
D
G
L
V
L
G
R
V
L
G
S
G
A
F
G
K
V
V
E
G
T
A
Y
G
L
S
R
S
Q
P
--
V
M
K
V
A
V
K
M
L
K
-
P
T
A
R
S
S
E
K
Q
A
L
M
S
E
L
K
I
M
T
H
L
G
P
H
L
N
I
V
N
L
L
G
A
C
T
-
K
-
S
-----
G
P
I
Y
I
I
T
E
Y
C
F
Y
G
D
L
V
N
Y
L
H
----------
K
N
R
D
S
F
-
L
S
-----------
N
S
-
E
G
----
L
---
T
L
L
D
L
L
S
F
T
Y
Q
V
A
R
G
M
E
F
L
A
S
K
N
C
V
H
R
D
L
A
A
R
N
V
L
L
A
---
Q
G
K
I
V
K
I
C
D
F
G
L
A
R
D
I
M
H
D
S
N
Y
V
S
K
G
S
T
F
L
P
V
K
W
M
A
P
E
S
I
F
D
N
L
Y
T
T
L
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
G
T
P
Y
P
G
M
M
V
D
-
S
-
T
F
Y
N
K
I
K
S
G
-------
Y
R
M
A
K
P
D
H
A
T
S
E
V
Y
E
I
M
V
K
C
W
N
S
E
P
E
K
R
P
S
F
Y
H
L
S
E
I
V
E
N
L
L
-
P
G
Q
Y
------------------------------------------------------------
594
HHSearch
74.57
55%
-121
- C6 -
-
4CKJ
16
A:
[15-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
-
K
-
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
K
G
R
--
A
G
Y
T
T
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-----
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
----------
E
S
R
K
V
------------------
R
A
----
L
---
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-
V
---------------------------------------------------------------
312
Blastp_CBE
74.56
49%
-100
- C6 -
-
6ITT
2
?
A:
[29-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
-
K
-
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
--
D
A
A
M
T
V
A
V
K
M
L
K
-
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-----
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
D
S
-------------
E
D
D
E
-
L
A
----
L
---
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
-
S
E
S
T
------------------------------------------------------------
314
Blastp_CBE
74.54
51%
-112
- C6 -
-
2I1M
1
A:
[34-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
N
E
-
K
-
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
--
D
A
V
L
K
V
A
V
K
M
L
K
-
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
-----------
R
K
S
R
V
-
L
E
T
---
D
---------
S
T
----
A
---
S
T
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
---------------------------------------------------------------------
595
HHSearch
74.46
51%
-101
- C6 -
-
6HH1
1
?
A:
[12-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
H
-
K
-
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
--
D
A
A
M
T
V
A
V
K
M
L
K
-
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-----
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
D
S
F
-
I
C
S
---
K
T
S
--
P
A
I
E
-
L
A
----
L
---
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
-
S
K
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
------------------------------------------------------------------
579
HHSearch
74.34
55%
-124
- C6 -
-
5FM3
1
A:
[55-351]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
P
-
K
-
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
K
G
R
--
A
G
Y
T
T
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-----
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
----------
E
S
----------------------
A
----
L
---
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-----------------------------------------------------------------
316
Blastp_CBE
74.28
49%
-104
- C6 -
-
3G0F
1
?
A:
[34-331]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
-
K
-
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
--
D
A
A
M
T
V
A
V
K
M
L
K
-
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-----
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
D
S
F
-----------------------
L
---
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
H
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
-
S
E
--------------------------------------------------------------
204
Blastp_CBE
74.10
56%
-115
- C6 -
-
2I0Y
1
?
A:
[26-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
N
E
-
K
-
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
--
D
A
V
L
K
V
A
V
K
M
L
K
-
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
---------------------
Q
----
L
---
S
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
---------------------------------------------------------------------
271
Blastp_CBE
73.99
50%
-96
- C6 -
-
6GQJ
1
?
B:
[29-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
-
K
-
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
G
L
I
K
S
--
D
A
A
M
T
V
A
V
K
M
L
K
-
P
S
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
D
E
F
-
V
P
-----------
Y
K
-
D
F
----
L
---
T
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
N
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
K
Q
I
-
S
E
S
-------------------------------------------------------------
205
Blastp_CBE
73.98
56%
-113
- C6 -
-
2I0V
1
A:
[34-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
N
E
-
K
-
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
--
D
A
V
L
K
V
A
V
K
M
L
K
-
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
---------------------
Q
----
L
---
S
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
---------------------------------------------------------------------
317
Blastp_CBE
73.97
50%
-117
- C6 -
-
3LCD
1
?
A:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
N
E
-
K
-
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
--
D
A
V
L
K
V
A
V
K
M
L
K
-
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
A
E
A
D
-
L
D
---------------
P
----
L
---
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
--
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
---------------------------------------------------------------------
297
Blastp_CBE
73.91
49%
-108
- C6 -
-
6T2W
1
?
A:
[27-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
N
E
-
K
-
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
--
D
A
V
L
K
V
A
V
K
M
L
K
-
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
A
E
A
M
-
L
---------------
R
P
----
L
---
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
---------------------------------------------------------------------
269
Blastp_CBE
73.85
50%
-99
- C6 -
-
6GQK
1
?
B:
[29-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
-
K
-
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
G
L
I
K
S
--
D
A
A
M
T
V
A
V
K
M
L
K
-
P
S
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
D
E
F
-
V
P
Y
K
-
V
----------
D
F
----
L
---
T
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
N
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
K
Q
I
-
S
E
S
-------------------------------------------------------------
201
Blastp_CBE
73.75
56%
-115
- C6 -
-
3KRL
1
A:
[18-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
N
E
-
K
-
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
--
D
A
V
L
K
V
A
V
K
M
L
K
-
S
T
A
-
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
---------------------
Q
----
L
---
S
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
---------------------------------------------------------------------
305
Blastp_CBE
73.74
51%
-110
- C6 -
-
3BEA
1
A:
[34-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
N
E
-
K
-
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
--
D
A
V
L
K
V
A
V
K
M
L
K
-
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
-----------
R
K
S
R
V
-
L
---------------
S
T
----
L
---
S
T
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
---------------------------------------------------------------------
268
Blastp_CBE
73.68
50%
-97
- C6 -
-
6GQL
1
KIT_HUMAN
A:
[29-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
-
K
-
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
G
L
I
K
S
--
D
A
A
M
T
V
A
V
K
M
L
K
-
P
S
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
D
E
F
-
V
P
Y
---------
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
N
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
K
Q
I
-
S
E
S
-------------------------------------------------------------
272
Blastp_CBE
73.27
50%
-95
- C6 -
-
6GQJ
1
?
A:
[29-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
-
K
-
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
G
L
I
K
S
--
D
A
A
M
T
V
A
V
K
M
L
K
-
P
S
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
D
E
F
-
V
P
Y
K
----------
K
-
D
F
----
L
---
T
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
N
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
K
Q
I
-
S
E
S
-------------------------------------------------------------
308
Blastp_CBE
72.91
49%
-105
- C6 -
-
1PKG
1
KIT_HUMAN
A:
[27-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
-
K
-
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
--
D
A
A
M
T
V
A
V
K
M
L
K
-
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-----
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
D
S
F
-
I
C
S
K
-------------
A
----
L
---
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
------------------------------------------------------------------
265
Blastp_CBE
72.73
50%
-97
- C6 -
-
6GQM
1
?
B:
[31-325]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
H
-
K
-
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
G
L
I
K
S
--
D
A
A
M
T
V
A
V
K
M
L
K
-
P
S
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
D
E
F
-
V
P
Y
K
----------
K
-
D
F
----
L
---
T
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
N
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
K
Q
I
-
S
E
S
-------------------------------------------------------------
267
Blastp_CBE
72.56
50%
-98
- C6 -
-
6GQL
1
KIT_HUMAN
B:
[31-325]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
H
-
K
-
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
G
L
I
K
S
--
D
A
A
M
T
V
A
V
K
M
L
K
-
P
S
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
D
E
F
-
V
P
Y
K
-------------
F
----
L
---
T
L
E
H
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
N
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
K
Q
I
-
S
E
S
-------------------------------------------------------------
166
Blastp_CBE
72.46
86%
-77
- C6 -
-
6AGX
1
FGFR2_HUMAN
A:
[1-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
--------
I
N
----
R
V
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
-----
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
203
Blastp_CBE
72.11
56%
-114
- C6 -
-
3DPK
1
A:
[30-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
N
E
-
K
-
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
-----
A
V
L
K
V
A
V
K
M
L
K
-
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
-----------------------
Q
----
L
---
S
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
----
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
---------------------------------------------------------------------
336
Blastp_CBE
72.00
41%
-119
- C6 -
-
3NW6
1
A:
[13-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
-
Q
-
G
-----
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
----------
S
L
R
P
----
E
M
E
-
N
N
P
V
--
L
A
P
P
-----------
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
R
F
V
M
E
G
-------
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
---------------------------------------------------------------------
335
Blastp_CBE
71.59
41%
-120
- C6 -
-
3NW7
1
A:
[13-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
-
Q
-
G
-----
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
----------
S
L
R
P
----
E
M
E
-
N
N
P
V
--
L
A
P
P
-----------
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
R
F
V
M
E
G
-------
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
---------------------------------------------------------------------
303
Blastp_CBE
71.45
49%
-52
- C6 -
-
6MOB
1
KIT_HUMAN
A:
[10-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
-
K
-
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
--
D
A
A
M
T
V
A
V
K
M
L
K
-
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-----
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
D
S
F
-
I
C
S
K
-
T
S
P
A
IM
E
D
D
E
-
L
A
----
L
---
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
-
S
E
--------------------------------------------------------------
355
Blastp_CBE
71.35
41%
-125
- C6 -
-
3LW0
2
IGF1R_HUMAN
A:
[10-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
-
Q
-
G
-----
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
----------
S
L
R
P
----------------
P
P
-----------
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
R
F
V
M
E
G
-------
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
---------------------------------------------------------------------
307
Blastp_CBE
71.30
49%
-108
- C6 -
-
1PKG
1
B:
[27-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
-
K
-
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
--
D
A
A
M
T
V
A
V
K
M
L
K
-
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-----
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
D
S
F
-
I
C
--------------------
L
---
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
-------------
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
-
S
---------------------------------------------------------------
163
Blastp_CBE
71.12
86%
-53
- C6 -
-
6AGX
1
?
D:
[1-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
G
-
M
E
S
D
-
I
N
----
R
V
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
352
Blastp_CBE
70.99
41%
-123
- C6 -
-
3LW0
2
D:
[10-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
-
Q
-
G
-----
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
----------
S
L
R
P
----------------
P
P
-----------
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
R
F
V
M
E
G
-------
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
---------------------------------------------------------------------
354
Blastp_CBE
70.97
41%
-123
- C6 -
-
3LW0
3
IGF1R_HUMAN
B:
[10-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
-
Q
-
G
-----
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
----------
S
L
R
P
----------------
P
P
-----------
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
R
F
V
M
E
G
-------
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
---------------------------------------------------------------------
341
Blastp_CBE
70.84
41%
-125
- C6 -
-
3I81
1
A:
[13-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
-
Q
-
G
-----
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
----------
S
L
R
P
----
E
-
E
-
N
N
P
V
--
L
A
P
P
-----------
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
-----
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
R
F
V
M
E
G
-------
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
---------------------------------------------------------------------
258
Blastp_CBE
70.80
52%
-99
- C6 -
-
2IVU
3
A:
[2-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
S
L
S
V
D
A
F
K
I
L
-
D
P
-
K
-
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
R
A
G
Y
T
T
-
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-----
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
----------
E
S
R
--------------------
R
A
----
L
---
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
-
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-
V
---------------------------------------------------------------
353
Blastp_CBE
70.76
41%
-123
- C6 -
-
3LW0
3
IGF1R_HUMAN
C:
[10-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
-
Q
-
G
-----
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
----------
S
L
R
P
----------------
P
P
-----------
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
R
F
V
M
E
G
-------
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
---------------------------------------------------------------------
165
Blastp_CBE
70.67
86%
-55
- C6 -
-
6AGX
1
B:
[1-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
-
K
-
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
----------
A
R
R
P
P
G
-
M
E
S
D
-
I
N
----
R
V
P
E
-
E
Q
----
M
---
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
-
T
L
T
-------------------------------------------------------------
276
Blastp_CBE
70.25
49%
-42
- C6 -
-
4HVS
1
A:
[34-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
-
K
-
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
G
L
I
K
S
--
D
A
A
M
T
V
A
V
K
M
L
K
-
P
S
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
D
S
F
-
H
S
S
D
-
T
S
P
A
SM
E
D
D
E
-
N
A
----
L
---
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
S
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
K
Q
I
-
S
E
S
-------------------------------------------------------------
260
Blastp_CBE
70.22
52%
-107
- C6 -
-
5AMN
8
A:
[2-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
S
L
S
V
D
A
F
K
I
--
D
P
-
K
-
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
R
A
G
Y
T
T
-
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-----
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
----------
E
S
R
K
V
----------------
E
-
R
A
----
L
---
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
E
E
D
S
V
Y
-
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-
V
---------------------------------------------------------------
585
HHSearch
70.16
40%
-129
- C6 -
-
3BKB
7
A:
[108-374]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
-------
N
T
L
V
A
V
K
S
C
R
-
E
T
L
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
-
K
-----
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
----------
T
E
G
--------------------
A
R
----
L
---
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
-
G
A
S
P
Y
P
N
L
S
N
Q
-
Q
-
T
R
-
E
F
V
E
K
G
-------
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
-
K
---------------------------------------------------------------
263
Blastp_CBE
70.14
51%
-99
- C6 -
-
6NE7
3
A:
[2-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
S
L
S
V
D
A
F
K
I
L
E
D
P
-
K
-
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
R
A
G
Y
T
T
-
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-----
G
P
L
L
L
I
V
E
Y
A
K
Y
A
S
L
R
G
F
L
R
----------
E
S
R
K
V
G
---------------
E
-
R
A
----
L
---
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
E
E
D
S
V
Y
-
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-
V
---------------------------------------------------------------
313
Blastp_CBE
69.94
49%
-56
- C6 -
-
3G0E
1
?
A:
[34-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
-
K
-
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
--
D
A
A
M
T
V
A
V
K
M
L
K
-
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-----
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
D
S
F
-
I
C
S
K
-
T
S
P
A
IM
E
D
D
E
-
L
A
----
L
---
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
-
S
E
S
-------------------------------------------------------------
420
Blastp_CBE
69.82
39%
-132
- C6 -
-
3IK3
1
ABL1_MOUSE
B:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
544
Blastp_CBE
69.79
39%
-136
- C6 -
-
2HYY
1
ABL1_HUMAN
D:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
--
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------------------------------------------------------------
495
Blastp_CBE
69.71
38%
-143
- C6 -
-
4ZOG
2
ABL1_HUMAN
B:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
--
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
593
HHSearch
69.70
56%
-51
- C6 -
-
4ASE
1
A:
[58-347]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
--
T
A
T
C
R
T
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
-
P
G----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
----------
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
E
F
C
-
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
---------------------------------------------------------------
589
HHSearch
69.69
56%
-50
- C6 -
-
4ASD
1
A:
[58-347]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
--
T
A
T
C
R
T
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
-
P
G----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
----------
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
E
F
C
-
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
---------------------------------------------------------------
332
Blastp_CBE
69.62
41%
-118
- C6 -
-
3QQU
1
IGF1R_HUMAN
C:
[7-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
-
Q
-
G
-----
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
----------
S
L
R
P
----
E
M
-----
V
--
L
A
P
P
-----------
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
R
F
V
M
E
G
-------
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
---------------------------------------------------------------------
298
Blastp_CBE
69.57
49%
-62
- C6 -
-
6IL3
13
A:
[47-355]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
D
N
E
Y
F
Y
V
D
F
R
E
Y
E
Y
--
D
L
-
K
-
W
E
F
P
R
E
N
L
E
F
G
K
V
L
G
S
G
A
F
G
K
V
M
N
A
T
A
Y
G
I
S
K
T
G
V
S
--
I
Q
V
A
V
K
M
L
K
-
E
K
A
D
S
S
E
R
E
A
L
M
S
E
L
K
M
M
T
Q
L
G
S
H
E
N
I
V
N
L
L
G
A
C
T
-
L
-
S
-----
G
P
I
Y
L
I
F
E
Y
C
C
Y
G
D
L
L
N
Y
L
R
----------
S
K
R
E
K
F
S-----------------------NVL
T
F
E
D
L
L
C
F
A
Y
Q
V
A
K
G
M
E
F
L
E
F
K
S
C
V
H
R
D
L
A
A
R
N
V
L
V
T
---
H
G
K
V
V
K
I
C
D
F
G
L
A
R
D
I
M
S
D
S
N
Y
V
V
R
G
N
A
R
L
P
V
K
W
M
A
P
E
S
L
F
E
G
I
Y
T
I
K
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
V
N
P
Y
P
G
I
P
V
D
A
N
-
F
Y
-
K
L
I
Q
N
G
-------
F
K
M
D
Q
P
F
Y
A
T
E
E
I
Y
I
I
M
Q
S
C
W
A
F
D
S
R
K
R
P
S
F
P
N
L
T
S
F
L
---------------------------------------------------------------------
520
Blastp_CBE
69.56
38%
-135
- C6 -
-
2G1T
1
ABL1_HUMAN
B:
[5-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
338
Blastp_CBE
69.54
41%
-119
- C6 -
-
2OJ9
1
A:
[13-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
-
Q
-
G
-----
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
----------
S
L
R
P
----
E
-----------
P
P
-----------
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
R
F
V
M
E
G
-------
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
---------------------------------------------------------------------
560
Blastp_CBE
69.52
39%
-138
- C6 -
-
6BL8
1
ABL1_HUMAN
A:
[2-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
F
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
P
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
587
HHSearch
69.46
37%
-116
- C6 -
-
6BRJ
1
DDR1_HUMAN
A:
[568-872]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
-----------
L
L
V
A
V
K
I
L
R
-
P
D
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
-
Q
-
D
-----
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
----------
A
H
Q
L
E
D
-----------------
P
T
----
I
---
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
-
Q
-
V
I
-
E
N
A
G
E
F
FRDQGRQ
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
-----------------------------------------------------------------
452
Blastp_CBE
69.46
39%
-139
- C6 -
-
6HD6
2
ABL1_MOUSE
A:
[8-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
--
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
259
Blastp_CBE
69.46
52%
-96
- C6 -
-
2IVT
3
A:
[2-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
S
L
S
V
D
A
F
K
I
---
P
-
K
-
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
R
A
G
Y
T
T
-
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-----
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
----------
E
S
R
K
V
------------------
R
A
----
L
---
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
-
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-
V
---------------------------------------------------------------
254
Blastp_CBE
69.43
52%
-107
- C6 -
-
2X2M
5
B:
[2-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
S
L
S
V
D
A
F
K
I
---
P
-
K
-
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
----
K
V
V
K
A
T
A
F
H
L
-
K
G
R
A
G
Y
T
T
-
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-----
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
----------
E
S
----------------------
A
----
L
---
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
-
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-
V
---------------------------------------------------------------
535
Blastp_CBE
69.38
39%
-134
- C6 -
-
3CS9
1
ABL1_HUMAN
D:
[10-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
---------
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------------------------------------------------------------
257
Blastp_CBE
69.38
52%
-99
- C6 -
-
2X2K
4
A:
[2-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
S
L
S
V
D
A
F
K
I
---
P
-
K
-
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
R
A
G
Y
T
T
-
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-----
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
----------
E
S
R
K
V
------------------
R
A
----
L
---
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
-
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-
V
---------------------------------------------------------------
491
Blastp_CBE
69.36
39%
-141
- C6 -
-
4TWP
1
ABL1_HUMAN
B:
[2-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
253
Blastp_CBE
69.34
52%
-95
- C6 -
-
4CKJ
17
A:
[2-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
S
L
S
V
D
A
F
K
I
L
E
D
P
-
K
-
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
R
A
G
Y
T
T
-
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-----
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
----------
E
S
R
K
V
------------------
R
A
----
L
---
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
-
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-
V
---------------------------------------------------------------
540
Blastp_CBE
69.24
39%
-136
- C6 -
-
2HZI
1
ABL1_HUMAN
A:
[10-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------------------------------------------------------------
462
Blastp_CBE
69.24
39%
-136
- C6 -
-
3K5V
2
ABL1_MOUSE
A:
[8-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
-
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
466
Blastp_CBE
69.23
39%
-133
- C6 -
-
1M52
3
ABL1_MOUSE
B:
[10-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
299
Blastp_CBE
69.22
49%
-67
- C6 -
-
6IG8
2
?
A:
[19-315]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
N
E
-
K
-
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
--
D
A
V
L
K
V
A
V
K
M
L
K
-
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
A
E
A
M
-
L
G
P
S
-
L
---------G
R
P
----
L
---
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
---------------------------------------------------------------------
557
Blastp_CBE
69.17
38%
-139
- C6 -
-
3PYY
1
ABL1_HUMAN
A:
[18-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-----
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
-------------------------------------------------------------
518
Blastp_CBE
69.20
38%
-135
- C6 -
-
2G1T
1
ABL1_HUMAN
D:
[5-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
296
Blastp_CBE
69.18
49%
-72
- C6 -
-
5X02
1
A:
[24-332]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
D
N
E
Y
F
Y
V
D
F
R
E
Y
E
Y
--
D
L
-
K
-
W
E
F
P
R
E
N
L
E
F
G
K
V
L
G
S
G
A
F
G
K
V
M
N
A
T
A
Y
G
I
S
K
T
G
V
S
--
I
Q
V
A
V
K
M
L
K
-
E
K
A
D
S
S
E
R
E
A
L
M
S
E
L
K
M
M
T
Q
L
G
S
H
E
N
I
V
N
L
L
G
A
C
T
-
L
-
S
-----
G
P
I
Y
L
I
F
E
Y
C
C
Y
G
D
L
L
N
Y
L
R
----------
S
K
R
E
K
F
S-----------------------VL-
T
F
E
D
L
L
C
F
A
Y
Q
V
A
K
G
M
E
F
L
E
F
K
S
C
V
H
R
D
L
A
A
R
N
V
L
V
T
---
H
G
K
V
V
K
I
C
D
F
G
L
A
R
D
I
M
S
D
S
N
Y
V
V
R
G
N
A
R
L
P
V
K
W
M
A
P
E
S
L
F
E
G
I
Y
T
I
K
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
V
N
P
Y
P
G
I
P
V
D
A
N
-
F
Y
-
K
L
I
Q
N
G
-------
F
K
M
D
Q
P
F
Y
A
T
E
E
I
Y
I
I
M
Q
S
C
W
A
F
D
S
R
K
R
P
S
F
P
N
L
T
S
F
L
---------------------------------------------------------------------
290
Blastp_CBE
69.17
49%
-63
- C6 -
-
6N33
1
A:
[38-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
N
E
-
K
-
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
--
D
A
V
L
K
V
A
V
K
M
L
K
-
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
----------
R
K
A
E
A
M
-
L
G
P
S
-
L
S
--------G
R
P
----
L
---
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
F
L
---------------------------------------------------------------------
454
Blastp_CBE
69.14
39%
-137
- C6 -
-
6HD4
3
ABL1_MOUSE
A:
[8-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
-
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
256
Blastp_CBE
69.14
52%
-97
- C6 -
-
2X2L
5
A:
[2-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
S
L
S
V
D
A
F
K
I
L
--
P
-
K
-
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
R
A
G
Y
T
T
-
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-----
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
----------
E
S
R
K
V
------------------
R
A
----
L
---
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
-
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-
V
---------------------------------------------------------------
478
Blastp_CBE
69.11
39%
-133
- C6 -
-
2QOH
1
ABL1_MOUSE
B:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
----
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
496
Blastp_CBE
69.13
38%
-136
- C6 -
-
4ZOG
5
ABL1_HUMAN
A:
[5-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
293
Blastp_CBE
69.11
49%
-67
- C6 -
-
4HW7
1
A:
[38-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
N
E
-
K
-
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
--
D
A
V
L
K
V
A
V
K
M
L
K
-
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
----------
R
K
A
E
A
M
-
L
G
P
S
-----------G
R
P
----
L
---
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
F
L
---------------------------------------------------------------------
555
Blastp_CBE
69.06
38%
-138
- C6 -
-
6NPE
2
ABL1_HUMAN
A:
[18-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
--------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
-------------------------------------------------------------
262
Blastp_CBE
69.08
51%
-99
- C6 -
-
6NJA
3
A:
[2-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
S
L
S
V
D
A
F
K
I
L
E
D
P
-
K
-
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
R
A
G
Y
T
T
-
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-----
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
----------
E
S
R
K
V
----------------
E
-
R
A
----
L
---
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
E
E
D
S
V
Y
-
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-
V
---------------------------------------------------------------
553
Blastp_CBE
69.06
38%
-141
- C6 -
-
6NPU
2
ABL1_HUMAN
A:
[18-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
--------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
-------------------------------------------------------------
449
Blastp_CBE
69.05
38%
-76
- C6 -
-
3LCS
3
A:
[44-333]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
M
P
N
D
-
P
S
P
L
-
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-----
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
----------
E
T
R
P
---------
R
P
S
--
Q
--
P
-
S
S
----
L
---
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
-
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
-------------------------------------------------
411
Blastp_CBE
69.02
39%
-128
- C6 -
-
3OY3
1
ABL1_MOUSE
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
492
Blastp_CBE
68.94
39%
-142
- C6 -
-
4TWP
1
ABL1_HUMAN
A:
[2-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
------
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
475
Blastp_CBE
68.94
39%
-128
- C6 -
-
3KFA
1
ABL1_MOUSE
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
311
Blastp_CBE
68.92
49%
-56
- C6 -
-
6ITT
2
?
B:
[29-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
H
-
K
-
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
--
D
A
A
M
T
V
A
V
K
M
L
K
-
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-----
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
R
-------------M-
E
D
D
E
-
L
A
----
L
---
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
-
S
E
S
T
------------------------------------------------------------
387
Blastp_CBE
68.90
37%
-112
- C6 -
-
3EKN
1
A:
[13-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
S
-
K
-
G
-----
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
----------
S
L
R
P
----
E
A
E
-
N
N
P
G
--
R
P
P
P
-----------
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
K
F
V
M
D
G
-------
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
-------------------
D
D
L
H
P
S
F
P
E
V
---------------------------------------
516
Blastp_CBE
68.89
38%
-140
- C6 -
-
3UE4
1
ABL1_HUMAN
B:
[8-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
--
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
292
Blastp_CBE
68.88
49%
-65
- C6 -
-
4R7H
1
A:
[38-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
N
E
-
K
-
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
--
D
A
V
L
K
V
A
V
K
M
L
K
-
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
----------
R
K
A
E
A
M
-
L
G
P
S
-
L
---------G
R
P
----
L
---
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
F
L
---------------------------------------------------------------------
519
Blastp_CBE
68.86
38%
-136
- C6 -
-
2G1T
1
ABL1_HUMAN
C:
[7-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
448
Blastp_CBE
68.85
38%
-74
- C6 -
-
3LCT
3
A:
[44-334]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
M
P
N
D
-
P
S
P
L
-
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-----
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
----------
E
T
R
P
---------
R
P
S
--
Q
--
P
-
S
S
----
L
---
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
-
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
-
E
-----------------------------------------------
551
Blastp_CBE
68.80
38%
-138
- C6 -
-
6NPV
2
ABL1_HUMAN
A:
[18-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
--------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
-------------------------------------------------------------
530
Blastp_CBE
68.78
38%
-130
- C6 -
-
2G2H
1
ABL1_HUMAN
A:
[8-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
291
Blastp_CBE
68.74
49%
-66
- C6 -
-
4R7I
1
?
A:
[38-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
N
E
-
K
-
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
--
D
A
V
L
K
V
A
V
K
M
L
K
-
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
----------
R
K
A
E
A
M
-
L
G
P
S
-
L
S
--------G
R
P
----
L
---
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
F
L
---------------------------------------------------------------------
474
Blastp_CBE
68.70
39%
-127
- C6 -
-
3KFA
1
ABL1_MOUSE
B:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
264
Blastp_CBE
68.71
51%
-95
- C6 -
-
4CKI
9
A:
[2-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
S
L
S
V
D
A
F
K
I
L
E
D
P
-
K
-
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
R
A
G
Y
T
T
-
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-----
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
----------
E
S
R
K
V
---------------
D
E
-
R
A
----
L
---
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
E
E
D
S
V
Y
-
K
R
S
Q
G
R
I
P
V
K
W
T
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-
V
---------------------------------------------------------------
464
Blastp_CBE
68.70
39%
-135
- C6 -
-
1OPJ
2
ABL1_MOUSE
B:
[8-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
433
Blastp_CBE
68.65
38%
-75
- C6 -
-
4CNH
2
B:
[26-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
--------
S
P
L
-
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-----
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
----------
E
T
R
P
---------
R
-------
P
-
S
S
----
L
---
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
S
Y
-----
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
-
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
-
E
-----------------------------------------------
255
Blastp_CBE
68.63
52%
-105
- C6 -
-
2X2M
4
RET_HUMAN
A:
[2-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
S
L
S
V
D
A
F
K
I
L
-
D
P
-
K
-
W
E
F
P
R
K
N
L
V
L
G
K
T
L
--
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
R
A
G
Y
T
T
-
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-----
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
----------
E
S
---------------------
R
A
----
L
---
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
-
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-
V
---------------------------------------------------------------
479
Blastp_CBE
68.62
39%
-132
- C6 -
-
2QOH
1
ABL1_MOUSE
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
---
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
548
Blastp_CBE
68.59
38%
-134
- C6 -
-
4XEY
1
ABL1_HUMAN
B:
[96-386]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
V
Y
G
V
S
----
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
------
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
----
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
549
Blastp_CBE
68.58
38%
-133
- C6 -
-
4XEY
1
ABL1_HUMAN
A:
[116-386]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
----
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
421
Blastp_CBE
68.55
39%
-137
- C6 -
-
3IK3
1
ABL1_MOUSE
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
-------
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
410
Blastp_CBE
68.57
39%
-127
- C6 -
-
3OY3
1
ABL1_MOUSE
B:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
301
Blastp_CBE
68.55
50%
-70
- C6 -
-
4XUF
1
B:
[1-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
-
K
-
W
E
F
P
R
E
N
L
E
F
G
K
V
L
G
S
G
A
F
G
K
V
M
N
A
T
A
Y
G
I
S
K
T
G
V
S
--
I
Q
V
A
V
K
M
L
K
-
E
K
A
D
S
S
E
R
E
A
L
M
S
E
L
K
M
M
T
Q
L
G
S
H
E
N
I
V
N
L
L
G
A
C
T
-
L
-
S
-----
G
P
I
Y
L
I
F
E
Y
C
C
Y
G
D
L
L
N
Y
L
R
----------
S
K
R
---------------------------NVL
T
F
E
D
L
L
C
F
A
Y
Q
V
A
K
G
M
E
F
L
E
F
K
S
C
V
H
R
D
L
A
A
R
N
V
L
V
T
---
H
G
K
V
V
K
I
C
D
F
G
L
A
R
D
I
M
S
D
S
N
Y
V
V
R
G
N
A
R
L
P
V
K
W
M
A
P
E
S
L
F
E
G
I
Y
T
I
K
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
V
N
P
Y
P
G
I
P
V
D
A
N
-
F
Y
-
K
L
I
Q
N
G
-------
F
K
M
D
Q
P
F
Y
A
T
E
E
I
Y
I
I
M
Q
S
C
W
A
F
D
S
R
K
R
P
S
F
P
N
L
T
S
F
L
---------------------------------------------------------------------
422
Blastp_CBE
68.54
39%
-133
- C6 -
-
2Z60
1
ABL1_MOUSE
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
---
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
386
Blastp_CBE
68.51
40%
-111
- C6 -
-
4IBM
1
?
A:
[12-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
S
-
K
-
G
-----
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
----------
S
L
R
P
----
E
A
E
-
N
N
P
G
--
R
P
P
P
-----------
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
K
F
V
M
D
G
-------
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
---------------------------------------------------------------------
529
Blastp_CBE
68.44
38%
-134
- C6 -
-
2G2H
1
ABL1_HUMAN
B:
[8-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
477
Blastp_CBE
68.43
39%
-135
- C6 -
-
3KF4
1
ABL1_MOUSE
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
--------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
532
Blastp_CBE
68.29
38%
-130
- C6 -
-
2G2F
1
ABL1_HUMAN
A:
[7-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
481
Blastp_CBE
68.29
39%
-144
- C6 -
-
3QRJ
1
ABL1_HUMAN
A:
[12-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
------
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------------------------------------------------------------------
538
Blastp_CBE
68.24
39%
-138
- C6 -
-
3CS9
1
ABL1_HUMAN
A:
[10-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-----
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------------------------------------------------------------
586
HHSearch
68.23
37%
-108
- C6 -
-
6BSD
1
DDR1_HUMAN
A:
[567-872]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
--------
P
L
L
V
A
V
K
I
L
R
-
P
D
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
-
Q
-
D
-----
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
----------
A
H
Q
L
E
D
-
K
A
------------
G
-
P
T
----
I
---
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
--
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
-
Q
-
V
I
-
E
N
A
G
E
F
FRDQGRQ
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
-----------------------------------------------------------------
333
Blastp_CBE
68.20
41%
-120
- C6 -
-
3QQU
1
IGF1R_HUMAN
B:
[7-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
-
Q
-
G
-----
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
----------
S
L
R
------------------
P
-----------
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
R
F
V
M
E
G
-------
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
---------------------------------------------------------------------
499
Blastp_CBE
68.16
39%
-133
- C6 -
-
3QRK
1
ABL1_HUMAN
A:
[8-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
------------------------------------------------------------------
542
Blastp_CBE
68.14
39%
-142
- C6 -
-
2HZ4
1
ABL1_HUMAN
B:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
-----
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------------------------------------------------------------
445
Blastp_CBE
68.17
38%
-80
- C6 -
-
4CD0
1
A:
[41-332]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
--------
S
P
L
-
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-----
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
----------
E
T
R
P
---------
R
P
S
--
Q
--
P
-
S
S
----
L
---
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
-
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
-
E
Y
----------------------------------------------
547
Blastp_CBE
68.12
39%
-131
- C6 -
-
2HYY
1
ABL1_HUMAN
A:
[8-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
--
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------------------------------------------------------------
453
Blastp_CBE
68.16
39%
-135
- C6 -
-
6HD4
2
ABL1_MOUSE
B:
[8-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
----
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
514
Blastp_CBE
68.14
38%
-142
- C6 -
-
4YC8
3
ABL1_HUMAN
B:
[8-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
------
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
469
Blastp_CBE
68.12
39%
-131
- C6 -
-
1IEP
1
ABL1_MOUSE
A:
[8-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
---------------------------------------------------------------
521
Blastp_CBE
68.11
38%
-136
- C6 -
-
2G1T
1
ABL1_HUMAN
A:
[7-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
528
Blastp_CBE
68.00
38%
-124
- C6 -
-
2G2I
1
ABL1_HUMAN
A:
[5-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
---
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
467
Blastp_CBE
68.00
39%
-131
- C6 -
-
1M52
1
ABL1_MOUSE
A:
[10-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
459
Blastp_CBE
67.99
39%
-135
- C6 -
-
3MS9
2
ABL1_MOUSE
B:
[8-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
----
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
---------------------------------------------------------------
482
Blastp_CBE
67.97
40%
-133
- C6 -
-
3HMI
1
ABL2_HUMAN
A:
[26-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
----
V
G
V
W
K
K
Y
S
---
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-----
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
E
E
----
V
---
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
D
L
L
E
K
G
-------
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
--------------------------------------------------------------------------
334
Blastp_CBE
67.96
41%
-125
- C6 -
-
3QQU
1
IGF1R_HUMAN
A:
[7-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
-
Q
-
G
-----
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
----------
S
L
R
-----------------
P
P
-----------
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
R
F
V
M
E
G
-------
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
---------------------------------------------------------------------
392
Blastp_CBE
67.92
37%
-116
- C6 -
-
1I44
1
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
S
-
K
-
G
-----
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
----------
S
L
R
P
----
E
A
E
-
N
N
P
G
--
R
P
P
P
-----------
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
----------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
K
F
V
M
D
G
-------
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-------------------
D
D
L
H
P
S
F
P
E
V
---------------------------------------
331
Blastp_CBE
67.92
41%
-119
- C6 -
-
3QQU
1
D:
[7-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
-
Q
-
G
-----
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
----------
S
L
R
P
----
E
M
--------
L
A
P
P
-----------
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
R
F
V
M
E
G
-------
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
---------------------------------------------------------------------
300
Blastp_CBE
67.92
49%
-66
- C6 -
-
3LCO
1
A:
[19-315]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
N
E
-
K
-
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
--
D
A
V
L
K
V
A
V
K
M
L
K
-
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-----
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
----------
R
K
A
E
A
M
-
L
G
P
S
-----------G
R
P
----
L
---
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
----
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
---------------------------------------------------------------------
487
Blastp_CBE
67.91
38%
-77
- C6 -
-
4MKC
3
A:
[67-358]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
-------
S
P
L
-
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-----
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
----------
E
T
R
P
---------
R
P
S
--
Q
--
P
-
S
S
----
L
---
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
-
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
-
E
Y
----------------------------------------------
442
Blastp_CBE
67.88
38%
-79
- C6 -
-
4CLJ
1
A:
[26-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
--------
S
P
L
-
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-----
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
----------
E
T
R
P
---------
R
P
S
--
Q
--
P
-
S
S
----
L
---
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
-
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
-
E
Y
----------------------------------------------
534
Blastp_CBE
67.84
39%
-122
- C6 -
-
2HZ0
1
ABL1_HUMAN
A:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------------------------------------------------------------
501
Blastp_CBE
67.84
39%
-131
- C6 -
-
3QRI
1
ABL1_HUMAN
A:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------------------------------------------------------------
476
Blastp_CBE
67.83
39%
-135
- C6 -
-
3KF4
1
ABL1_MOUSE
B:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
----
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
513
Blastp_CBE
67.82
38%
-126
- C6 -
-
2HIW
1
ABL1_HUMAN
A:
[5-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
--------------------------------------------------------------
517
Blastp_CBE
67.72
38%
-130
- C6 -
-
3UE4
1
ABL1_HUMAN
A:
[8-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
446
Blastp_CBE
67.69
38%
-83
- C6 -
-
3AOX
5
A:
[43-334]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
E
G
Q
V
--------
S
P
L
-
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-----
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
----------
E
T
R
P
---------
R
P
S
--
Q
--
P
-
S
S
----
L
---
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
-
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
-
E
Y
----------------------------------------------
215
Blastp_CBE
67.71
55%
-18
- C6 -
-
6GQP
1
?
A:
[16-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-
V
A
P
E
--
D
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
------------------------------------------------------------
400
Blastp_CBE
67.69
38%
-85
- C6 -
-
5AA9
1
A:
[26-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
---------
P
L
-
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-----
L
P
R
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
----------
E
T
R
P
---------
R
P
S
--
Q
--
P
-
S
S
----
L
---
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
-
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
-
E
Y
----------------------------------------------
497
Blastp_CBE
67.63
38%
-135
- C6 -
-
4WA9
1
ABL1_HUMAN
B:
[7-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
213
Blastp_CBE
67.65
55%
-11
- C6 -
-
3VNT
4
A:
[17-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
---------
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
------------------------------------------------------------
261
Blastp_CBE
67.63
51%
-99
- C6 -
-
2IVV
3
A:
[2-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
S
L
S
V
D
A
F
K
I
-----
K
-
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
R
A
G
Y
T
T
-
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-----
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
----------
E
S
R
--------------------------
L
---
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
S
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
-
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-
V
---------------------------------------------------------------
545
Blastp_CBE
67.58
39%
-135
- C6 -
-
2HYY
1
ABL1_HUMAN
C:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
-
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
---
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------------------------------------------------------------
480
Blastp_CBE
67.62
39%
-130
- C6 -
-
3QRJ
1
ABL1_HUMAN
B:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------------------------------------------------------------
461
Blastp_CBE
67.59
39%
-133
- C6 -
-
3K5V
2
ABL1_MOUSE
B:
[8-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
----
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
465
Blastp_CBE
67.58
39%
-128
- C6 -
-
1OPJ
2
ABL1_MOUSE
A:
[8-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
444
Blastp_CBE
67.51
38%
-82
- C6 -
-
4Z55
3
A:
[39-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
--------
S
P
L
-
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-----
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
----------
E
T
R
P
---------
R
P
--------------
L
---
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
-
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
-
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
-------------------------------------------------
539
Blastp_CBE
67.48
39%
-147
- C6 -
-
2HZI
1
ABL1_HUMAN
B:
[10-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
-----
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------------------------------------------------------------
216
Blastp_CBE
67.43
55%
-12
- C6 -
-
6GQO
1
A:
[15-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-
V
A
P
E
--
D
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
------------------------------------------------------------
218
Blastp_CBE
67.41
55%
-10
- C6 -
-
3U6J
1
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
--
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-
V
A
P
E
--
D
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
Q
Q
D
---------------------------------------------------------
515
Blastp_CBE
67.35
38%
-145
- C6 -
-
4YC8
3
ABL1_HUMAN
A:
[8-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
------
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
-----
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
559
Blastp_CBE
67.36
39%
-137
- C6 -
-
6BL8
1
ABL1_HUMAN
B:
[2-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
---
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
F
T
A
H
-
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
P
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
429
Blastp_CBE
67.35
38%
-83
- C6 -
-
5KZ0
1
A:
[26-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
---------
P
L
-
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-----
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
----------
E
T
R
P
---------
R
P
S
--
Q
--
P
-
S
S
----
L
---
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
-
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
-
E
Y
----------------------------------------------
524
Blastp_CBE
67.25
38%
-129
- C6 -
-
2F4J
1
ABL1_HUMAN
A:
[4-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
455
Blastp_CBE
67.25
39%
-137
- C6 -
-
3MSS
2
ABL1_MOUSE
D:
[5-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
---------------------------------------------------------------
210
Blastp_CBE
67.23
55%
-15
- C6 -
-
4AG8
1
A:
[15-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
----------
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
------------------------------------------------------------
463
Blastp_CBE
67.21
39%
-121
- C6 -
-
2HZN
1
ABL1_MOUSE
A:
[8-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
---
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
---
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
546
Blastp_CBE
67.20
39%
-131
- C6 -
-
2HYY
1
ABL1_HUMAN
B:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
-
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------------------------------------------------------------
212
Blastp_CBE
67.15
55%
-12
- C6 -
-
3VO3
2
A:
[17-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-------
D
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
------------------------------------------------------------
468
Blastp_CBE
67.10
39%
-125
- C6 -
-
1IEP
1
ABL1_MOUSE
B:
[8-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
---------------------------------------------------------------
500
Blastp_CBE
67.09
39%
-140
- C6 -
-
3QRI
1
ABL1_HUMAN
B:
[10-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
------
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------------------------------------------------------------
424
Blastp_CBE
67.07
40%
-141
- C6 -
-
4XLI
1
ABL2_MOUSE
A:
[2-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
----
V
G
V
W
K
---
K
Y
S
L
T
V
A
V
K
T
L
K
-----
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-----
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
S
R
-
E
E
----
V
---
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
D
L
L
E
K
G
-------
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
--------------------------------------------------------------------------
536
Blastp_CBE
67.02
39%
-147
- C6 -
-
3CS9
1
ABL1_HUMAN
C:
[9-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
------
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
-------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------------------------------------------------------------
456
Blastp_CBE
67.02
39%
-136
- C6 -
-
3MSS
2
ABL1_MOUSE
C:
[5-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
---------------------------------------------------------------
552
Blastp_CBE
66.98
38%
-149
- C6 -
-
6NPU
5
ABL1_HUMAN
B:
[19-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
----------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
488
Blastp_CBE
66.89
38%
-72
- C6 -
-
3L9P
4
A:
[67-357]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
------
S
P
L
-
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-----
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
----------
E
T
R
P
---------
R
P
S
--
Q
--
P
-
S
S
----
L
---
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
-
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
-
E
-----------------------------------------------
423
Blastp_CBE
66.89
40%
-139
- C6 -
-
4XLI
1
B:
[2-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
----
G
E
V
Y
----
V
G
V
W
K
---
K
Y
S
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-----
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
S
R
-
E
E
----
V
---
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
D
L
L
E
K
G
-------
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
--------------------------------------------------------------------------
211
Blastp_CBE
66.83
55%
-15
- C6 -
-
2XIR
1
A:
[15-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
----------
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
------------------------------------------------------------
531
Blastp_CBE
66.84
38%
-128
- C6 -
-
2G2F
1
ABL1_HUMAN
B:
[9-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
-----
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
206
Blastp_CBE
66.83
55%
-15
- C6 -
-
3WZE
2
A:
[7-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-------
D
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
-
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
-------------------------------------------------------------
214
Blastp_CBE
66.82
55%
-14
- C6 -
-
6GQQ
1
A:
[15-312]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-
V
A
P
E
--
D
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
-------------------------------------------------------------
554
Blastp_CBE
66.77
38%
-150
- C6 -
-
6NPE
3
ABL1_HUMAN
B:
[19-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
523
Blastp_CBE
66.81
39%
-130
- C6 -
-
5HU9
13
ABL1_HUMAN
A:
[7-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
---------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------------------------------------------------------------
280
Blastp_CBE
66.80
48%
-27
- C6 -
-
3VHK
2
A:
[17-365]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
SKRNEFVPYK-------------------------YKDF
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
------------------------------------------------------------
512
Blastp_CBE
66.79
38%
-124
- C6 -
-
2HIW
1
ABL1_HUMAN
B:
[5-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
--------------------------------------------------------------
458
Blastp_CBE
66.78
39%
-136
- C6 -
-
3MSS
2
ABL1_MOUSE
A:
[5-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
---------------------------------------------------------------
457
Blastp_CBE
66.77
39%
-137
- C6 -
-
3MSS
2
ABL1_MOUSE
B:
[5-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
---------------------------------------------------------------
451
Blastp_CBE
66.74
39%
-131
- C6 -
-
6HD6
1
ABL1_MOUSE
B:
[8-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
----
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
220
Blastp_CBE
66.69
55%
-12
- C6 -
-
4ASD
1
A:
[52-350]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
----------
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
------------------------------------------------------------
319
Blastp_CBE
66.62
47%
-114
- C6 -
-
6MWE
1
B:
[23-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
N
F
G
Q
V
L
K
A
R
I
-----
K
K
D
G
L
R
M
D
A
A
I
K
R
---------------
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
-
H
-
R
-----
G
Y
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
----------
K
S
R
V
L
E
-
T
D
P
A
-
F
A
I
A
--
N
S
T
A
-
S
T
----
L
---
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
---
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
G
Q
---
E
V
---
K
T
M
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
-
G
G
T
P
Y
C
G
M
T
C
A
-
E
-
L
Y
-
E
K
L
P
Q
G
-------
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
-----------------------------------------------------------------
527
Blastp_CBE
66.61
38%
-128
- C6 -
-
2G2I
1
ABL1_HUMAN
B:
[7-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
----
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
-------------------------------------------------------------
537
Blastp_CBE
66.52
39%
-151
* C6 *
-
3CS9
1
ABL1_HUMAN
B:
[10-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
----
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
-------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------------------------------------------------------------
460
Blastp_CBE
66.53
39%
-130
- C6 -
-
3MS9
2
ABL1_MOUSE
A:
[8-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
--
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
---------------------------------------------------------------
404
Blastp_CBE
66.55
38%
-85
- C6 -
-
4ANS
1
A:
[41-332]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
Q
V
---------
P
L
-
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-----
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
----------
E
T
R
P
---------
R
P
S
--
Q
--
P
-
S
S
----
L
---
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
-
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
-
E
Y
----------------------------------------------
450
Blastp_CBE
66.53
39%
-140
- C6 -
-
3OXZ
1
ABL1_MOUSE
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
-----------
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
219
Blastp_CBE
66.52
55%
-15
- C6 -
-
4ASE
1
A:
[52-350]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
----------
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
------------------------------------------------------------
484
Blastp_CBE
66.51
40%
-132
- C6 -
-
2XYN
4
ABL2_HUMAN
C:
[27-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
----
V
G
V
W
K
K
Y
S
---
L
T
V
A
V
K
T
L
K
---
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-----
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
E
E
----
V
---
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
D
L
L
E
K
G
-------
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
--------------------------------------------------------------------------
550
Blastp_CBE
66.50
38%
-145
- C6 -
-
6NPV
5
ABL1_HUMAN
B:
[19-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
----------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
302
Blastp_CBE
66.46
50%
-71
- C6 -
-
4XUF
1
FLT3_HUMAN
A:
[1-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
-
K
-
W
E
F
P
R
E
N
L
E
F
G
K
V
L
G
S
G
A
F
G
K
V
M
N
A
T
A
Y
G
I
S
K
T
G
V
S
--
I
Q
V
A
V
K
M
L
K
-
E
---
S
S
E
R
E
A
L
M
S
E
L
K
M
M
T
Q
L
G
S
H
E
N
I
V
N
L
L
G
A
C
T
-
L
-
S
-----
G
P
I
Y
L
I
F
E
Y
C
C
Y
G
D
L
L
N
Y
L
R
----------
S
K
R
---------------------------L--
T
F
E
D
L
L
C
F
A
Y
Q
V
A
K
G
M
E
F
L
E
F
K
S
C
V
H
R
D
L
A
A
R
N
V
L
V
T
---
H
G
K
V
V
K
I
C
D
F
G
L
A
R
D
I
M
S
D
S
N
Y
V
V
R
G
N
A
R
L
P
V
K
W
M
A
P
E
S
L
F
E
G
I
Y
T
I
K
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
V
N
P
Y
P
G
I
P
V
D
A
N
-
F
Y
-
K
L
I
Q
N
G
-------
F
K
M
D
Q
P
F
Y
A
T
E
E
I
Y
I
I
M
Q
S
C
W
A
F
D
S
R
K
R
P
S
F
P
N
L
T
S
F
L
---------------------------------------------------------------------
471
Blastp_CBE
66.41
39%
-121
- C6 -
-
1FPU
1
ABL1_MOUSE
A:
[8-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
--------------------------------------------------------------
273
Blastp_CBE
66.36
52%
-70
- C6 -
-
6FEK
4
A:
[2-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
S
L
S
V
D
A
F
K
I
L
A
A
P
-
K
-
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
R
A
G
Y
T
T
-
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-----
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
----------
E
S
R
K
V
G
--------
P
G
--
P
D
-
E
-
R
A
----
L
---
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
E
E
-
D
F
V
K
R
S
-
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-
V
---------------------------------------------------------------
502
Blastp_CBE
66.32
38%
-131
- C6 -
-
2E2B
1
ABL1_HUMAN
B:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
------
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
-------
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------------------------------------------------------------
221
Blastp_CBE
66.31
55%
-9
- C6 -
-
4AGD
1
A:
[52-350]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
----------
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
------------------------------------------------------------
485
Blastp_CBE
66.26
40%
-132
- C6 -
-
2XYN
4
ABL2_HUMAN
B:
[26-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
----
V
G
V
W
K
K
Y
S
---
L
T
V
A
V
K
T
L
---
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-----
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
E
E
----
V
---
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
D
L
L
E
K
G
-------
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
--------------------------------------------------------------------------
403
Blastp_CBE
66.26
38%
-84
- C6 -
-
4ANQ
1
A:
[41-332]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
Q
V
---------
P
L
-
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-----
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
----------
E
T
R
P
---------
R
P
S
--
Q
--
P
-
S
S
----
L
---
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
-
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
-
E
Y
----------------------------------------------
238
Blastp_CBE
66.15
55%
-17
- C6 -
-
3B8R
2
VGFR2_HUMAN
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
-----
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-
V
A
P
E
--
D
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
-----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
Q
Q
D
---------------------------------------------------------
470
Blastp_CBE
66.13
39%
-121
- C6 -
-
1FPU
1
ABL1_MOUSE
B:
[8-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
------
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
--------------------------------------------------------------
222
Blastp_CBE
66.11
55%
-17
- C6 -
-
4AGC
1
A:
[52-350]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
----------
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
------------------------------------------------------------
503
Blastp_CBE
66.10
38%
-129
- C6 -
-
2E2B
1
ABL1_HUMAN
A:
[8-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
-----
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
----
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
413
Blastp_CBE
66.06
38%
-87
- C6 -
-
6EDL
1
A:
[26-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
-------
S
P
L
-
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-----
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
----------
E
T
R
P
---------
R
P
S
--
Q
--
P
-
S
S
----
L
---
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
----------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
-
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
-------------------------------------------------
486
Blastp_CBE
66.02
40%
-134
- C6 -
-
2XYN
2
ABL2_HUMAN
A:
[26-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
----
V
G
V
W
K
K
Y
S
---
L
T
V
A
V
K
T
L
---
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-----
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
E
E
----
V
---
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
D
L
L
E
K
G
-------
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
--------------------------------------------------------------------------
320
Blastp_CBE
65.85
47%
-119
- C6 -
-
6MWE
1
TIE2_HUMAN
A:
[23-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
N
F
G
Q
V
L
K
A
R
I
-----
K
K
D
G
L
R
M
D
A
A
I
K
R
M
--------------
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
-
H
-
R
-----
G
Y
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
----------
K
S
R
V
L
E
-
T
D
P
A
-
F
A
I
A
--
N
S
T
A
-
S
T
----
L
---
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
---
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
G
Q
---
E
V
Y
--
K
T
M
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
-
G
G
T
P
Y
C
G
M
T
C
A
-
E
-
L
Y
-
E
K
L
P
Q
G
-------
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
-----------------------------------------------------------------
428
Blastp_CBE
65.84
38%
-76
- C6 -
-
4TT7
5
A:
[17-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
E
G
Q
V
--------
S
P
L
-
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-----
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
----------
E
T
R
P
---------
R
-------
P
-
S
S
----
L
---
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
S
--
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
-
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
-
E
-----------------------------------------------
244
Blastp_CBE
65.73
55%
-13
- C6 -
-
2QU5
1
A:
[6-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-
V
A
P
E
--
D
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
-------------
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
Q
Q
----------------------------------------------------------
325
Blastp_CBE
65.68
47%
-127
- C6 -
-
2OO8
1
X:
[29-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
V
L
K
A
R
I
----------
R
M
D
A
A
I
K
R
M
K
-
E
---
K
D
D
H
R
D
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
-
H
----------
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
----------
K
S
R
V
L
E
-
T
D
P
A
-
F
A
I
A
--
N
S
T
A
-
S
T
----
L
---
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
---
E
N
Y
V
A
K
I
A
D
F
G
L
--------------
M
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
-
G
G
T
P
Y
C
G
M
T
C
A
-
E
-
L
Y
-
E
K
L
P
Q
G
-------
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
-----------------------------------------------------------------
217
Blastp_CBE
65.62
55%
-13
- C6 -
-
3EWH
2
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
---
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-
V
A
P
E
--
D
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
----
D
P
D
Y
V
-----
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
Q
Q
D
---------------------------------------------------------
207
Blastp_CBE
65.62
55%
-22
- C6 -
-
3WZD
10
A:
[7-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
----
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-
V
A
P
E
--
D
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
-------------------------------------------------------------
209
Blastp_CBE
65.61
55%
-20
- C6 -
-
5EW3
1
VGFR2_HUMAN
A:
[16-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-
V
--------
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
------------------------------------------------------------
321
Blastp_CBE
65.54
47%
-122
- C6 -
-
3L8P
1
A:
[23-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
N
F
G
Q
V
L
K
A
R
I
-----
K
K
D
G
L
R
M
D
A
A
I
K
R
M
------------
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
-
H
-
R
-----
G
Y
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
----------
K
S
R
V
L
E
-
T
D
P
A
-
F
A
I
A
--
N
S
T
A
-
S
T
----
L
---
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
---
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
G
Q
---
E
V
Y
V
K
K
-----
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
-
G
G
T
P
Y
C
G
M
T
C
A
-
E
-
L
Y
-
E
K
L
P
Q
G
-------
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
-----------------------------------------------------------------
556
Blastp_CBE
65.49
38%
-145
- C6 -
-
3PYY
3
ABL1_HUMAN
B:
[19-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
----------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
245
Blastp_CBE
65.45
55%
-14
- C6 -
-
2P2H
1
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
----
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-
V
A
P
E
--
D
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
---------------
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
Q
Q
D
---------------------------------------------------------
239
Blastp_CBE
65.40
55%
-17
- C6 -
-
3B8Q
1
B:
[6-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
---------
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
--------------------------------------------------------------
384
Blastp_CBE
65.39
41%
-127
- C6 -
-
4CSV
1
?
A:
[5-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
-------
Y
E
G
K
W
R
N
Y
N
I
E
V
A
V
K
T
L
K
-
E
G
T
M
--
S
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
L
Y
G
V
C
T
-
K
-
E
-----
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
----------
D
---------
C
-------
V
N
--------------
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
N
V
V
K
V
A
D
F
G
------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
-
G
Q
V
P
Y
P
G
M
S
G
S
-
E
-
V
I
-
E
Q
V
E
R
G
-------
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
-----------------------------------------------------------------
318
Blastp_CBE
65.32
43%
-80
- C6 -
-
4RT7
1
A:
[56-400]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
--
D
L
-
K
-
W
E
F
P
R
E
N
L
E
F
G
K
V
L
G
S
G
A
F
G
K
V
M
N
A
T
A
Y
G
I
S
--
G
V
S
--
I
Q
V
A
V
K
M
L
K
----
D
S
S
E
R
E
A
L
M
S
E
L
K
M
M
T
Q
L
G
S
H
E
N
I
V
N
L
L
G
A
C
T
-
L
-
S
-----
G
P
I
Y
L
I
F
E
Y
C
C
Y
G
D
L
L
N
Y
L
R
----------
S
K
R
---------------------------NVL
T
F
E
D
L
L
C
F
A
Y
Q
V
A
K
G
M
E
F
L
E
F
K
S
C
V
H
R
D
L
A
A
R
N
V
L
V
T
---
H
G
K
V
V
K
I
C
D
F
G
L
A
R
D
I
M
S
D
S
N
Y
V
V
R
G
N
A
R
L
P
V
K
W
M
A
P
E
S
L
F
E
G
I
Y
T
I
K
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
V
N
P
Y
P
G
I
P
V
D
A
N
-
F
Y
-
K
L
I
Q
N
G
-------
F
K
M
D
Q
P
F
Y
A
T
E
E
I
Y
I
I
M
Q
S
C
W
A
F
D
S
R
K
R
P
S
F
P
N
L
T
S
F
L
---------------------------------------------------------------------
237
Blastp_CBE
65.31
55%
-22
- C6 -
-
3B8R
1
B:
[7-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
----
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
---------
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
-----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
--------------------------------------------------------------
241
Blastp_CBE
65.28
55%
-11
- C6 -
-
2RL5
1
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-
V
A
P
E
--
D
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
--------------
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
Q
Q
D
---------------------------------------------------------
287
Blastp_CBE
65.25
49%
-22
- C6 -
-
3VHE
1
A:
[10-354]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
SKRNEFVPYK-----------------------
D
L
YKDF
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-----------------------------------------------------------------
224
Blastp_CBE
65.19
56%
-16
- C6 -
-
3EFL
1
VGFR2_HUMAN
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
---
T
C
R
T
--
V
A
V
K
M
L
K
-
E
--
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-
V
A
P
E
--
D
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
Q
Q
D
---------------------------------------------------------
294
Blastp_CBE
65.08
49%
-65
- C6 -
-
6JQR
5
?
A:
[14-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
D
N
E
Y
F
Y
V
D
F
R
E
Y
E
Y
--
D
L
-
K
-
W
E
F
P
R
E
N
L
E
F
G
K
V
L
G
S
G
A
F
G
K
V
M
N
A
T
A
Y
G
I
S
---
V
S
--
I
Q
V
A
V
K
M
L
K
-
E
--
D
S
S
E
R
E
A
L
M
S
E
L
K
M
M
T
Q
L
G
S
H
E
N
I
V
N
L
L
G
A
C
T
-
L
-
S
-----
G
P
I
Y
L
I
F
E
Y
C
C
Y
G
D
L
L
N
Y
L
R
----------
S
K
R
E
K
F
S-----------------------NVL
T
F
E
D
L
L
C
F
A
Y
Q
V
A
K
G
M
E
F
L
E
F
K
S
C
V
H
R
D
L
A
A
R
N
V
L
V
T
---
H
G
K
V
V
K
I
C
D
F
------
M
S
D
S
N
Y
V
V
R
G
N
A
R
L
P
V
K
W
M
A
P
E
S
L
F
E
G
I
Y
T
I
K
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
V
N
P
Y
P
G
I
P
V
D
A
N
-
F
Y
-
K
L
I
Q
N
G
-------
F
K
M
D
Q
P
F
Y
A
T
E
E
I
Y
I
I
M
Q
S
C
W
A
F
D
S
R
K
R
P
S
F
P
N
L
T
S
F
L
---------------------------------------------------------------------
240
Blastp_CBE
64.89
55%
-13
- C6 -
-
3B8Q
1
VGFR2_HUMAN
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-
V
A
P
E
--
D
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
Q
Q
D
---------------------------------------------------------
236
Blastp_CBE
64.80
55%
-13
- C6 -
-
3BE2
1
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
---
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-
V
A
P
E
--
D
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
Q
Q
D
---------------------------------------------------------
235
Blastp_CBE
64.79
55%
-12
- C6 -
-
3CP9
1
VGFR2_HUMAN
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
------
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-
V
A
P
E
--
D
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
Q
Q
D
---------------------------------------------------------
440
Blastp_CBE
64.72
38%
-86
- C6 -
-
4CCB
1
A:
[26-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
---------
P
L
-
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-----
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
----------
E
T
R
P
---------
R
-------
P
-
S
S
----
L
---
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
-
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
-
E
-----------------------------------------------
483
Blastp_CBE
64.56
40%
-131
- C6 -
-
3GVU
2
ABL2_HUMAN
A:
[26-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
----
V
G
V
W
K
K
Y
S
---
L
T
V
A
V
K
T
L
K
-
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-----
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
E
E
----
V
---
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
----
G
D
T
Y
T
----
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
D
L
L
E
K
G
-------
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
--------------------------------------------------------------------------
229
Blastp_CBE
64.56
55%
-9
- C6 -
-
3DTW
1
VGFR2_HUMAN
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
--
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-
V
A
P
E
--
D
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
Q
Q
D
---------------------------------------------------------
233
Blastp_CBE
64.54
55%
-17
- C6 -
-
3CPB
1
VGFR2_HUMAN
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
------
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-
V
A
P
E
--
D
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
Q
Q
D
---------------------------------------------------------
231
Blastp_CBE
64.21
55%
-18
- C6 -
-
3CPC
1
VGFR2_HUMAN
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
------
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-
V
A
P
E
--
D
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
Q
Q
D
---------------------------------------------------------
226
Blastp_CBE
64.21
56%
-24
- C6 -
-
2P2I
1
VGFR2_HUMAN
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
---
T
C
R
T
--
V
A
V
K
M
L
-----
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-
V
A
P
E
--
D
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
Q
Q
D
---------------------------------------------------------
383
Blastp_CBE
64.07
41%
-119
- C6 -
-
4UEU
1
?
A:
[3-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
D
--
K
-
W
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
-------
Y
E
G
K
W
R
N
Y
N
I
E
V
A
V
K
T
L
K
-
E
G
T
M
--
S
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
L
Y
G
V
C
T
-
K
-
E
-----
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
----------
D
---------
C
-
E
G
H
T
--
V
N
--------------
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
-----------
A
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
-
G
Q
V
P
Y
P
G
M
S
G
S
-
E
-
V
I
-
E
Q
V
E
R
G
-------
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
-----------------------------------------------------------------
208
Blastp_CBE
63.99
55%
-21
- C6 -
-
5EW3
1
B:
[15-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
----
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
-----------
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
---------------------------------------------------------------
533
Blastp_CBE
63.71
39%
-143
- C6 -
-
2HZ0
1
ABL1_HUMAN
B:
[3-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
-
K
-
W
E
M
E
R
T
D
I
T
M
K
H
K
L
------
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
K
T
L
-----
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-----------------------------------------------------------------
228
Blastp_CBE
63.62
55%
-20
- C6 -
-
3DTW
1
B:
[6-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
----
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
---------
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
----------------
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
--------------------------------------------------------------
324
Blastp_CBE
63.36
47%
-129
- C6 -
-
2OSC
1
A:
[30-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
L
K
A
R
I
-----------
M
D
A
A
I
K
R
M
K
-----
K
D
D
H
R
D
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
-
H
----------
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
----------
K
S
R
V
L
E
-
T
D
P
A
-
F
A
I
A
--
N
S
T
A
-
S
T
----
L
---
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
---
E
N
Y
V
A
K
I
A
D
F
G
L
--------------
M
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
-
G
G
T
P
Y
C
G
M
T
C
A
-
E
-
L
Y
-
E
K
L
P
Q
G
-------
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
-----------------------------------------------------------------
225
Blastp_CBE
63.29
56%
-20
- C6 -
-
2P2I
1
B:
[6-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
-----
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-------------
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
--------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
------------------------------------------------------------
327
Blastp_CBE
63.05
46%
-116
- C6 -
-
2WQB
1
A:
[30-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
--
G
Q
V
L
K
A
R
I
-----
K
K
D
G
L
R
M
D
A
A
I
K
R
M
K
--------------
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
-
H
-
R
-----
G
Y
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
----------
K
S
R
V
L
E
-
T
D
P
A
-
F
A
I
A
--
N
S
T
A
-
S
T
----
L
---
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
N
L
A
A
R
N
I
L
V
G
---
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
G
Q
---
E
V
Y
V
K
K
T
-
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
-
G
G
T
P
Y
C
G
M
T
C
A
-
E
-
L
Y
-
E
K
L
P
Q
G
-------
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
-----------------------------------------------------------------
498
Blastp_CBE
62.88
38%
-132
- C6 -
-
4WA9
1
ABL1_HUMAN
A:
[10-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
--
E
G
V
W
----
K
K
Y
S
L
T
-
V
A
V
-----------------------
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-----
P
---
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----------
E
---------
C
---------
N
R
-
Q
E
----
V
---
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
-
Q
E
S
S
------------------------------------------------------------
223
Blastp_CBE
62.83
56%
-24
- C6 -
-
3EFL
1
B:
[7-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
----
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-------------
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
---------------------------------------------------------------
322
Blastp_CBE
62.77
47%
-128
- C6 -
-
2P4I
1
B:
[29-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
V
L
K
A
R
I
----------
R
M
D
A
A
I
K
R
M
K
-
E
---
K
D
D
H
R
D
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
-
H
----------
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
----------
K
S
R
V
L
E
-
T
D
P
A
-
F
A
I
A
--
N
S
T
A
-
S
T
----
L
---
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
---
E
N
Y
V
A
K
I
A
D
F
G
L
---------------
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
-
G
G
T
P
Y
C
G
M
T
C
A
-
E
-
L
Y
-
E
K
L
P
Q
G
-------
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
-----------------------------------------------------------------
230
Blastp_CBE
62.75
55%
-20
- C6 -
-
3CPC
1
B:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
-----
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
----
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
-----------
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
---------------------------------------------------------------
243
Blastp_CBE
62.68
55%
-14
- C6 -
-
2QU6
1
VGFR2_HUMAN
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
-----
G
Q
V
I
E
A
D
A
F
G
I
D
K
--
T
C
R
T
--
V
A
V
K
M
L
K
----
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-
V
A
P
E
--
D
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
Q
Q
D
---------------------------------------------------------
288
Blastp_CBE
62.66
47%
-4
- C6 -
-
3HNG
1
A:
[14-360]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
A
R
E
R
L
K
L
G
K
S
L
G
R
G
A
F
G
K
V
V
Q
A
S
A
F
G
I
K
K
S
P
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
A
S
E
Y
K
A
L
M
T
E
L
K
I
L
T
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
Q
-
G
-----
G
P
L
M
V
I
V
E
Y
C
K
Y
G
N
L
S
N
Y
L
K
----------
S
K
R
------------------
K
-
E
P
----
I
---
T
M
E
D
L
I
S
Y
S
F
Q
V
A
R
G
M
E
F
L
S
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
N
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
N
P
D
Y
V
R
K
--
T
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
I
Y
S
T
K
S
D
V
W
S
Y
G
V
L
L
W
E
I
F
S
L
-
G
G
S
P
Y
P
G
V
Q
M
D
-
E
-
D
F
C
S
R
L
R
E
G
-------
M
R
M
R
A
P
E
Y
S
T
P
E
I
Y
Q
I
M
L
D
C
W
H
R
D
P
K
E
R
P
R
F
A
E
L
V
E
K
L
G
D
L
L
-----------------------------------------------------------------
234
Blastp_CBE
62.56
55%
-22
- C6 -
-
3CP9
1
B:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
----
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
-
V
--------
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
-----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
---------------------------------------------------------------
242
Blastp_CBE
62.39
55%
-14
- C6 -
-
2QU6
1
B:
[8-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
----
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
---------------
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
---------------------------------------------------------------
286
Blastp_CBE
62.38
49%
-6
- C6 -
-
3VID
1
A:
[8-352]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
SKRNEFVPYK------------------
E
A
P
E
-
D
L
YKDF
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
-------
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-----------------------------------------------------------------
232
Blastp_CBE
62.30
55%
-22
- C6 -
-
3CPB
1
B:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
-----
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
----
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
K
----------
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
---------------------------------------------------------------
282
Blastp_CBE
61.61
48%
-35
- C6 -
-
1Y6A
1
A:
[15-362]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
----
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
-----
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
SKRNEFVPY--------------------------DF--
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
--------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
-------------------------------------------------------------
323
Blastp_CBE
60.89
47%
-129
- C6 -
-
2P4I
1
TIE2_HUMAN
A:
[31-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
A
R
I
----------
R
M
D
A
A
I
K
R
---------------
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
-
H
----------
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
----------
K
S
R
V
L
E
-
T
D
P
A
-
F
A
I
A
--
N
S
T
A
-
S
T
----
L
---
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
---
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
--------
V
K
K
T
M
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
-
G
G
T
P
Y
C
G
M
T
C
A
-
E
-
L
Y
-
E
K
L
P
Q
G
-------
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
-----------------------------------------------------------------
281
Blastp_CBE
60.85
48%
-19
- C6 -
-
1Y6B
1
A:
[15-363]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
---
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
SKRNEFVPY--------------------------F---
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
--------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
------------------------------------------------------------
326
Blastp_CBE
60.27
46%
-136
- C6 -
-
4X3J
1
A:
[37-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
A
------------
R
M
D
A
A
I
K
-----------------
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
---------------
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
----------
K
S
R
V
L
E
-
T
D
P
A
-
F
A
I
A
--
N
S
T
A
-
S
T
----
L
---
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
N
L
A
A
R
N
I
L
V
G
---
E
N
Y
V
A
K
I
A
D
F
G
------------------
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
-
G
G
T
P
Y
C
G
M
T
C
A
-
E
-
L
Y
-
E
K
L
P
Q
G
-------
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
-----------------------------------------------------------------
227
Blastp_CBE
59.30
56%
-22
- C6 -
-
1YWN
1
A:
[15-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
-----
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
---------------
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
-----
I
K
D
P
D
V
R
K
--
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
Q
Q
D
---------------------------------------------------------
252
Blastp_CBE
59.06
56%
-12
- C6 -
-
2OH4
1
A:
[16-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
N
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
--
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
----------
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
K
D
P
D
V
R
K
--
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
Q
Q
D
---------------------------------------------------------
278
Blastp_CBE
58.58
52%
-64
- C6 -
-
5FM3
1
A:
[49-352]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
F
K
I
L
E
D
P
-
K
-
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
R
A
G
Y
T
T
-
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-----
G
P
L
L
L
I
V
E
Y
A
-
K
G
S
L
R
G
F
L
R
----------
E
S
R
--------------------------
L
---
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
--
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
T
T
-
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-
V
---------------------------------------------------------------
396
Blastp_CBE
58.29
41%
-15
- C6 -
-
5U6B
1
UFO_HUMAN
C:
[10-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
E
K
L
-
R
D
V
M
V
D
R
H
K
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
---
L
N
Q
D
--
D
S
I
L
K
V
A
V
K
T
M
K
I
A
I
C
T
R
S
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
-
D
H
P
N
V
M
R
L
I
G
V
C
F
-
Q
--P----
A
P
V
-
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
L
----------
Y
S
R
L
-
G
-
D
Q
P
V
-
Y
L
P
T
--
Q
M
-----------------
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
---
E
N
M
S
V
C
V
A
D
F
G
L
S
K
----------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
-
G
Q
T
P
Y
P
G
V
E
N
S
-
E
-
I
Y
-
D
Y
L
R
Q
G
-------
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
R
E
D
L
E
N
T
L
K
A
L
P
P
A
-----------------------------------------------------------
398
Blastp_CBE
58.25
41%
-17
- C6 -
-
5U6B
1
UFO_HUMAN
A:
[10-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
E
K
L
-
R
D
V
M
V
D
R
H
K
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
---
L
N
Q
D
--
D
S
I
L
K
V
A
V
K
T
M
K
I
A
I
C
T
R
S
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
-
D
H
P
N
V
M
R
L
I
G
V
C
F
-
Q
--P----
A
P
V
-
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
L
----------
Y
S
R
L
-
G
-
D
Q
P
V
-
Y
L
P
T
--
Q
M
-----------------
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
---
E
N
M
S
V
C
V
A
D
F
G
L
S
K
----------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
-
G
Q
T
P
Y
P
G
V
E
N
S
-
E
-
I
Y
-
D
Y
L
R
Q
G
-------
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
R
E
D
L
E
N
T
L
K
A
L
P
P
A
-----------------------------------------------------------
279
Blastp_CBE
58.05
52%
-65
- C6 -
-
5FM2
1
A:
[52-352]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
L
E
D
P
-
K
-
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
R
A
G
Y
T
T
-
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-----
G
P
L
L
L
I
V
E
Y
A
-
K
G
S
L
R
G
F
L
R
----------
E
S
R
--------------------------
L
---
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
--
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
T
T
-
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-
V
---------------------------------------------------------------
397
Blastp_CBE
57.68
41%
8
- C6 -
-
5U6B
1
UFO_HUMAN
B:
[6-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
S
E
-
E
L
K
E
K
L
-
R
D
V
M
V
D
R
H
K
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
---
L
N
Q
----
S
I
L
K
V
A
V
K
T
M
K
I
A
I
C
T
R
S
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
-
D
H
P
N
V
M
R
L
I
G
V
C
F
----RESFP
A
P
V
-
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
L
----------
Y
S
R
L
-
G
-
D
Q
P
V
-
Y
L
P
T
--
Q
M
-----------------
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
---
E
N
M
S
V
C
V
A
D
F
G
L
S
K
K
I
Y
N
G
D
Y
Y
---
R
I
A
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
-
G
Q
T
P
Y
P
G
V
E
N
S
-
E
-
I
Y
-
D
Y
L
R
Q
G
-------
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
R
E
D
L
E
N
T
L
K
A
L
P
-------------------------------------------------------------
395
Blastp_CBE
57.54
41%
9
- C6 -
-
5U6B
1
D:
[6-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
S
E
-
E
L
K
E
K
L
-
R
D
V
M
V
D
R
H
K
V
A
L
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
Q
---
L
N
Q
----
S
I
L
K
V
A
V
K
T
M
K
I
A
I
C
T
R
S
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
-
D
H
P
N
V
M
R
L
I
G
V
C
F
----RESFP
A
P
V
-
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
L
----------
Y
S
R
L
-
G
-
D
Q
P
V
-
Y
L
P
T
--
Q
M
-----------------
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
---
E
N
M
S
V
C
V
A
D
F
G
L
S
K
K
I
Y
N
G
D
Y
Y
---
R
I
A
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
-
G
Q
T
P
Y
P
G
V
E
N
S
-
E
-
I
Y
-
D
Y
L
R
Q
G
-------
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
R
E
D
L
E
N
T
L
K
A
L
P
-------------------------------------------------------------
511
Blastp_CBE
55.45
37%
-44
- C6 -
-
1RQQ
1
INSR_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
S
-
K
-
G
-----
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
----------
S
L
R
P
----
E
A
E
-
N
N
P
G
--
R
P
P
P
-----------
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
K
F
V
M
D
G
-------
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
-------------------
D
D
L
H
P
S
F
P
E
V
---------------------------------------
526
Blastp_CBE
55.05
37%
-41
- C6 -
-
1GAG
1
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
S
-
K
-
G
-----
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
----------
S
L
R
P
----
E
A
E
-
N
N
P
G
--
R
P
P
P
-----------
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
K
F
V
M
D
G
-------
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-------------------
D
D
L
H
P
S
F
P
E
V
---------------------------------------
522
Blastp_CBE
54.98
37%
-43
- C6 -
-
2Z8C
1
A:
[9-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
S
-
K
-
G
-----
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
----------
S
L
R
P
----
E
A
E
-
N
N
P
G
--
R
P
P
P
-----------
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
K
F
V
M
D
G
-------
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-------------------
D
D
L
H
P
S
F
P
E
V
---------------------------------------
525
Blastp_CBE
54.93
37%
-41
- C6 -
-
1IR3
1
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
S
-
K
-
G
-----
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
----------
S
L
R
P
----
E
A
E
-
N
N
P
G
--
R
P
P
P
-----------
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
K
F
V
M
D
G
-------
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-------------------
D
D
L
H
P
S
F
P
E
V
---------------------------------------
510
Blastp_CBE
54.92
37%
-42
- C6 -
-
1RQQ
1
B:
[12-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
S
-
K
-
G
-----
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
----------
S
L
R
P
----
E
A
E
-
N
N
P
G
--
R
P
P
P
-----------
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
K
F
V
M
D
G
-------
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
-------------------
D
D
L
H
P
S
F
P
E
V
---------------------------------------
275
Blastp_CBE
54.40
55%
-20
- C6 -
-
3C7Q
1
A:
[17-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
---
T
A
T
R
T
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
----
E
F
V
P
Y
--------
K
-
D
F
----
L
---
T
L
E
H
L
I
Y
C
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
-
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
---
D
P
D
V
R
K
--
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-
Q
A
N
A
Q
Q
D
---------------------------------------------------------
558
Blastp_CBE
54.13
39%
-53
- C6 -
-
4XLV
1
?
A:
[34-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
N
A
R
D
I
I
K
G
E
A
E
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
S
-
K
-
G
-----
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
----------
S
L
R
P
----
E
A
E
-
N
N
P
G
--
R
P
P
P
-----------
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
K
F
V
M
D
G
-------
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
------------------------------------------------------------------------
277
Blastp_CBE
50.31
55%
-6
- C6 -
-
3CJF
1
A:
[15-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
N
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
---
T
A
T
R
T
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
-------
F
V
P
Y
--
K
D
----
D
----
F
---
L
T
L
E
H
L
I
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
-
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
-
D
F
G
-
A
R
D
I
Y
K
D
P
D
------------
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
-
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-----------------------------------------------------------------
274
Blastp_CBE
49.88
55%
4
- C6 -
-
3CJG
1
A:
[15-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
K
-
W
E
F
P
R
D
R
L
N
L
G
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
D
K
---
T
A
T
R
T
V
A
V
K
M
L
K
-
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-----
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
----------
S
K
R
N
E
F
-
V
P
Y
-----
K
--
D
L
Y
K
-
D
F
----
L
---
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
-
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
--------------
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
-----------------------------------------------------------------