@TOME V3
(Feb 2022)
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Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : FGFR3_HUMAN: (2020-09-09 )
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
Atome Classification :
(466 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460-.-......470.......480.......490..-.....500..-.....510.......520.......530.......540....-.-.-.550.......560.......570..-----......580....--..----.590...-------....600.......610.......620....---...630.......640.......650.......660.......670.......680.......690........700.-..-.....710-----.........720.......730.......740.......750.......760.......770.......780.......790.......800....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGA
P
A
C
A
L
A
L
C
V
A
V
A
I
VAGASSESLG
T
E
Q
R
V
VGRAAEVPGPEPGQQ
E
Q
L
V
FGSG
D
A
V
E
L
SCPPPGGGPMG
P
T
V
W
V
KDGTGLVPSE
R
V
LV
G
P
Q
R
L
Q
V
L
NASHEDS
G
A
Y
S
C
R
Q
R
L
T
Q
R
V
L
C
H
F
S
V
R
V
TDAPSSGDDEDGED
E
A
E
DTGVDTGAPYWT
R
P
E
R
MDK
K
L
L
AVPAA
N
T
V
R
F
RCPAAGNPTP
S
I
S
W
L
KN
G
R
E
FRGEHRIG
G
I
K
L
R
H
Q
Q
W
S
L
V
M
E
S
VVPSDRG
N
Y
T
C
V
V
ENKFGS
I
R
Q
T
Y
T
L
D
V
L
ERSPHR
P
I
L
QAGLPANQ
T
A
VLGSD
V
E
F
H
C
K
VYSDA
Q
P
H
I
Q
W
L
K
HVEVNGSKVGPDGT
P
Y
V
T
V
L
KTAGANTTDK
E
L
E
V
L
S
L
HNVTFEDAG
E
Y
T
C
LAGNSIGFSHH
S
A
W
L
V
V
LPA
E
E
E
L
VEADEA
G
S
V
Y
A
G
I
L
S
Y
G
V
G
F
F
L
F
I
L
V
V
A
A
V
T
L
C
RLRSPPKKGLGS
P
T
V
H
K
I
S
RFP
L
K
R
Q
V
SLESNASMSSNT
P
L
V
R
I
A
R
LSSGEGPTLAN
V
S
ELELPAD-P-KWELSR
A
R
L
TLGKPLGEGC
F
G
Q
V
V
M
A
E
AIGI-DKDRAAK
P
V
T
-
V
A
V
K
M
LKDDATD
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
GK
H
K
N
I
I
N
L
L
G
A
CT-Q-G-
G
P
L
Y
V
L
V
EYAAKG
N
L
R
E
F
L
R
AR-RPP-----GLDYSFDTCKP
P
E
--EQ----L
T
F
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
AAR
N
V
L
VT---ED
N
V
M
K
I
A
D
FGL
A
R
D
VHNLD
Y
Y
K
KTTNGRL
P
V
K
WM
A
P
E
A
L
F
D
R
V
Y
THQ
S
D
V
W
S
F
G
V
L
L
W
E
I
F
TL-GGSPYPGI
P
V
E
-
E
-
L
F
-
K
L
L
KEG-------HRMDKPANC
T
H
D
L
Y
M
I
M
R
E
C
W
HAAPSQR
P
T
F
K
Q
L
V
E
D
L
D
R
V
L
T
VTSTD
E
Y
LDLSA
P
F
E
QYSPGGQDTPSSSSSGDDS
V
F
AHDLLPPAPPSSGGSRT
2
PsiBlast_PDB
91.37
98%
-131
- C4 -
-
4K33
1
A:
[25-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
A
D
-
P
-
K
W
E
L
S
R
A
R
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
I
G
I
-
D
K
D
R
A
A
K
P
V
T
-
V
A
V
K
M
L
K
D
D
A
T
D
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
G
-
G
P
L
Y
V
L
V
E
Y
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
P
-----
G
L
D
Y
S
F
D
T
S
------
E
Q
----
L
T
F
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
V
H
N
L
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
H
D
L
Y
M
I
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
V
L
T
V
T
---------------------------------------------------
26
Blastp_CBE
89.03
85%
-129
- C4 -
-
4J98
1
FGFR2_HUMAN
B:
[17-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
-----
G
M
E
Y
S
Y
D
I
N
R
V
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
Q
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
13
PsiBlast_PDB
88.71
84%
-123
- C4 -
-
4J98
-
FGFR2_HUMAN
A:
[17-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
-----
G
M
E
Y
S
Y
D
I
N
R
V
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
Q
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
10
PsiBlast_PDB
88.23
82%
-124
- C4 -
-
5EG3
1
A:
[22-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
-----
G
-------
N
R
V
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
F
F
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
E
E
Y
L
D
L
S
Q
-----------------------------------------
50
Blastp_CBE
88.12
84%
-129
- C4 -
-
5UI0
1
B:
[18-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
-----
G
M
E
Y
S
Y
D
I
N
R
V
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
M
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
--------------------------------------------------
69
Blastp_CBE
87.99
83%
-128
- C4 -
-
4RWJ
1
FGFR1_HUMAN
A:
[9-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
G
V
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
L
E
Y
S
Y
N
P
S
H
N
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
------------------------------------------------
124
Blastp_CBE
87.84
83%
-126
- C4 -
-
4UWB
4
FGFR1_HUMAN
A:
[8-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
L
E
Y
S
--
P
S
H
N
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
-
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
40
Blastp_CBE
87.56
85%
-124
- C4 -
-
4J96
1
FGFR2_HUMAN
B:
[18-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
-----
G
M
E
Y
S
Y
D
I
N
R
V
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
M
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------------
66
Blastp_CBE
87.55
83%
-123
- C4 -
-
3TT0
1
FGFR1_HUMAN
A:
[54-358]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
L
E
Y
S
Y
N
P
S
H
N
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
140
Blastp_CBE
87.39
83%
-132
- C4 -
-
5AM7
1
FGFR1_HUMAN
A:
[3-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
----------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
------------------------------------------------
19
PsiBlast_PDB
87.34
84%
-122
- C4 -
-
4J96
-
FGFR2_HUMAN
A:
[17-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
---------
S
Y
D
I
N
R
V
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
M
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------------
77
Blastp_CBE
87.29
83%
-131
- C4 -
-
5AM6
1
FGFR1_HUMAN
A:
[2-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
G
V
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
-----------
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
138
Blastp_CBE
87.25
83%
-120
- C4 -
-
4RWK
1
FGFR1_HUMAN
A:
[9-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
G
V
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
L
E
Y
S
Y
N
P
S
H
N
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
------------------------------------------------
39
Blastp_CBE
87.17
85%
-134
- C4 -
-
4J99
1
B:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
-----
G
M
E
Y
S
Y
D
---------
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
T
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
155
Blastp_CBE
87.16
83%
-131
- C4 -
-
5VND
9
B:
[4-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
-----------
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
157
Blastp_CBE
87.15
81%
-133
- C4 -
-
3GQI
2
A:
[16-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
L
E
F
S
F
N
P
S
H
N
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-
L
D
L
S
M
-----------------------------------------
38
Blastp_CBE
87.04
85%
-132
- C4 -
-
4J99
1
?
C:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
-----
G
M
E
Y
S
Y
D
---------
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
T
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
122
Blastp_CBE
86.87
83%
-122
- C4 -
-
4UWC
10
FGFR1_HUMAN
A:
[9-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
L
E
Y
S
Y
-
P
S
H
N
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
183
Blastp_CBE
86.81
76%
-136
- C4 -
-
4QRC
1
A:
[24-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
-
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
A
R
P
D
Q
A
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
P
-----
G
P
D
L
S
P
D
G
P
R
S
S
E
--
G
P
----
L
S
F
P
V
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
---------------------------------------------------
110
Blastp_CBE
86.73
83%
-133
- C4 -
-
5EW8
1
FGFR1_HUMAN
A:
[8-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
-----------
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
174
Blastp_CBE
86.69
77%
-137
- C4 -
-
6JPJ
1
A:
[12-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
-
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
A
R
P
D
Q
A
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
P
-----
G
P
D
L
S
P
D
G
P
R
S
S
E
--
G
P
----
L
S
F
P
V
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
S
E
-------------------------------------------------
73
Blastp_CBE
86.69
83%
-125
- C4 -
-
3JS2
1
FGFR1_HUMAN
A:
[16-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
L
-------
H
N
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
149
Blastp_CBE
86.63
83%
-137
- C4 -
-
3RHX
5
FGFR1_HUMAN
A:
[5-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
-----------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
------------------------------------------------
88
Blastp_CBE
86.59
83%
-133
- C4 -
-
6ITJ
1
?
A:
[8-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
-----------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
121
Blastp_CBE
86.50
83%
-124
- C4 -
-
4UWC
9
B:
[3-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
L
E
Y
S
Y
---
H
N
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
------------------------------------------------
156
Blastp_CBE
86.46
83%
-122
- C4 -
-
5VND
10
FGFR1_HUMAN
A:
[7-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
L
E
Y
S
Y
N
P
S
H
N
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
-
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
106
Blastp_CBE
86.42
83%
-140
- C4 -
-
5O4A
2
FGFR1_HUMAN
A:
[8-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
-----------
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
------------------------------------------------
161
Blastp_CBE
86.40
83%
-136
- C4 -
-
3C4F
1
FGFR1_HUMAN
A:
[1-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
-----------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
24
Blastp_CBE
86.29
86%
-127
- C4 -
-
3B2T
1
B:
[1-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
L
A
G
V
S
E
Y
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
----
F
G
Q
V
V
M
A
E
A
V
G
I
---
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
---------------------
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
55
Blastp_CBE
86.08
84%
-123
- C4 -
-
5UGX
1
FGFR2_HUMAN
A:
[24-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
-----
G
M
E
Y
S
Y
D
I
N
R
V
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
V
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
118
Blastp_CBE
86.03
83%
-130
- C4 -
-
4V04
7
FGFR1_HUMAN
A:
[7-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
L
E
Y
S
--
P
S
H
N
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
--------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
9
PsiBlast_PDB
86.03
85%
-134
- C4 -
-
3RI1
1
?
A:
[13-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
--------------------
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
--------------------------------------------------
87
Blastp_CBE
86.00
83%
-131
- C4 -
-
6ITJ
1
?
B:
[2-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
L
E
Y
S
Y
-----
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
-----
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------
72
Blastp_CBE
85.86
83%
-126
- C4 -
-
3JS2
1
B:
[11-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
--------------------
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------
112
Blastp_CBE
85.85
83%
-134
- C4 -
-
4ZSA
1
FGFR1_HUMAN
A:
[8-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
-----------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
105
Blastp_CBE
85.85
83%
-136
- C4 -
-
5O4A
1
B:
[4-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
L
E
Y
S
Y
------
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-------------------------------------------------
150
Blastp_CBE
85.80
83%
-131
- C4 -
-
6P69
2
B:
[5-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
-----------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------
159
Blastp_CBE
85.69
83%
-138
- C4 -
-
5ZV2
1
FGFR1_HUMAN
A:
[4-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
---------------------
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
--
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------
160
Blastp_CBE
85.56
83%
-130
- C4 -
-
3C4F
1
B:
[1-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
-----------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
108
Blastp_CBE
85.46
83%
-135
- C4 -
-
5O49
1
FGFR1_HUMAN
A:
[8-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
-----------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
------------------------------------------------
49
Blastp_CBE
85.45
85%
-136
- C4 -
-
5UGL
1
A:
[24-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
------------------
R
V
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
V
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
45
Blastp_CBE
85.44
85%
-127
- C4 -
-
2PWL
1
FGFR2_HUMAN
B:
[24-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
-----
G
--------------
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
--------------------------------------------------
142
Blastp_CBE
85.40
83%
-124
- C4 -
-
5A4C
6
FGFR1_HUMAN
A:
[6-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
--
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
L
E
Y
S
Y
N
P
S
H
N
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
116
Blastp_CBE
85.40
83%
-134
- C4 -
-
4V05
4
FGFR1_HUMAN
A:
[8-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
-----------
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
29
Blastp_CBE
85.38
85%
-128
- C4 -
-
4J97
1
B:
[24-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
---
G
Q
V
V
M
A
E
A
V
G
I
-
D
-----
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
-----
G
------
I
N
R
V
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
37
Blastp_CBE
85.36
85%
-134
- C4 -
-
4J99
1
?
D:
[21-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
-----------------------
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
T
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
177
Blastp_CBE
85.34
77%
-141
- C4 -
-
6IUP
2
?
A:
[21-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
L
P
L
D
-
P
-
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
A
R
P
D
Q
A
S
T
-
V
A
V
K
M
L
K
--
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
--------------
P
R
S
S
E
--
G
P
----
L
S
F
P
V
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
---------------------------------------------------
139
Blastp_CBE
85.32
83%
-132
- C4 -
-
5AM7
1
B:
[3-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
----------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-----
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------
117
Blastp_CBE
85.24
83%
-131
- C4 -
-
4V04
6
B:
[2-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
--------------------
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
--------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
99
Blastp_CBE
85.20
83%
-140
- C4 -
-
5Z0S
1
B:
[7-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
-----------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
-
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------
111
Blastp_CBE
85.15
83%
-139
- C4 -
-
4ZSA
1
B:
[5-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
-----------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------
11
PsiBlast_PDB
85.10
85%
-126
- C4 -
-
3B2T
1
FGFR2_HUMAN
A:
[7-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
---
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
---------------------
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
Q
E
-----------------------------------------------
109
Blastp_CBE
85.08
83%
-129
- C4 -
-
5EW8
1
B:
[5-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
--------------------
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
--
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
566
HHSearch
85.07
87%
-115
- C4 -
-
6AGX
1
?
D:
[4-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
-----
G
M
E
Y
S
Y
D
I
N
R
V
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
-----------------------------------------------------
561
HHSearch
84.93
84%
-126
- C4 -
-
3TT0
1
FGFR1_HUMAN
A:
[61-355]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
L
E
Y
S
Y
N
P
S
H
N
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------
6
PsiBlast_PDB
84.92
83%
-131
- C4 -
-
2PVF
1
A:
[23-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
---
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
-----
G
M
E
Y
S
Y
----------
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
--------------------------------------------------
27
Blastp_CBE
84.89
85%
-128
- C4 -
-
4J97
1
?
D:
[22-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
-----
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
--------------
R
V
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
36
Blastp_CBE
84.85
85%
-134
- C4 -
-
2PVY
1
?
B:
[18-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
-----
G
-----
D
I
N
R
V
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
--
Y
Y
K
----
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
16
PsiBlast_PDB
84.80
84%
-132
- C4 -
-
2PVY
1
?
A:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
-----
G
M
----
D
I
N
R
V
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
127
Blastp_CBE
84.77
83%
-135
- C4 -
-
4NKA
2
B:
[2-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
--------------------
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
------
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
151
Blastp_CBE
84.60
83%
-129
- C4 -
-
6P69
3
FGFR1_HUMAN
A:
[6-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
-----------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
33
Blastp_CBE
84.59
85%
-129
- C4 -
-
2PZP
1
B:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
E
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
-----
G
-----------
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------------
23
Blastp_CBE
84.58
86%
-133
- C4 -
-
3RI1
1
FGFR2_HUMAN
B:
[13-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
---
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
--------------------
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------------
20
PsiBlast_PDB
84.55
84%
-123
- C4 -
-
2PWL
1
FGFR2_HUMAN
A:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
---------------------
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
565
HHSearch
84.44
84%
-138
- C4 -
-
5EW8
1
B:
[9-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
--------------------
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
--
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
----------------------------------------------------
41
Blastp_CBE
84.48
85%
-136
- C4 -
-
2Q0B
1
B:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
-----
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
-----------------
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------------
75
Blastp_CBE
84.47
83%
-136
- C4 -
-
5B7V
1
FGFR1_HUMAN
A:
[9-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
----
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
----------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-------------------------------------------------
32
Blastp_CBE
84.44
85%
-132
- C4 -
-
4J95
1
?
B:
[24-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
----------------------
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
18
PsiBlast_PDB
84.44
84%
-138
- C4 -
-
4J99
1
FGFR2_HUMAN
A:
[22-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
----------------------
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
--
D
Y
Y
K
--
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
68
Blastp_CBE
84.43
83%
-137
- C4 -
-
4RWJ
1
B:
[11-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
---------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
---------
Y
K
K
T
T
-
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-------------------------------------------------
107
Blastp_CBE
84.42
83%
-135
- C4 -
-
5O49
1
B:
[4-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
---
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
--------------
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
82
Blastp_CBE
84.40
83%
-138
- C4 -
-
1FGI
1
FGFR1_HUMAN
A:
[9-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
-----------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------
185
Blastp_CBE
84.36
77%
-139
- C4 -
-
4UXQ
1
A:
[8-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
L
P
L
D
-
P
-
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
A
R
P
D
Q
A
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
P
--------------------
G
P
----
L
S
F
P
V
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
---------------------------------------------------
123
Blastp_CBE
84.28
83%
-118
- C4 -
-
4UWB
3
B:
[3-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
L
E
Y
S
Y
---
H
N
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
115
Blastp_CBE
84.27
83%
-132
- C4 -
-
4V05
3
B:
[3-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
---
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
--------------------
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
----
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
------------------------------------------------
100
Blastp_CBE
84.25
83%
-139
- C4 -
-
5Z0S
1
FGFR1_HUMAN
A:
[7-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
-----------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------
31
Blastp_CBE
84.23
85%
-131
- C4 -
-
4J95
1
?
C:
[24-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
-----------------------
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
3
PsiBlast_PDB
84.23
79%
-134
- C4 -
-
5A46
4
FGFR1_HUMAN
A:
[28-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
L
----------
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
---
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
46
Blastp_CBE
84.20
85%
-129
- C4 -
-
2PY3
1
B:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
----
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
-----
G
-----------
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------------
17
PsiBlast_PDB
84.18
84%
-134
- C4 -
-
4J95
1
FGFR2_HUMAN
A:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
----------------------
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
----
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
25
Blastp_CBE
84.14
85%
-134
- C4 -
-
2PZR
1
B:
[23-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
-----------------
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
R
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------------
15
PsiBlast_PDB
84.13
84%
-131
- C4 -
-
4J97
1
FGFR2_HUMAN
A:
[24-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
---
G
Q
V
V
M
A
E
A
V
G
I
---
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
-----
G
----------
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
74
Blastp_CBE
84.10
83%
-141
- C4 -
-
5B7V
1
B:
[7-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
-
D
--
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
------------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-----
D
Y
Y
K
K
T
T
-
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------
43
Blastp_CBE
84.09
85%
-135
- C4 -
-
2PZ5
1
B:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
T
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
--------------------
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------------
154
Blastp_CBE
84.08
83%
-141
- C4 -
-
6P68
1
FGFR1_HUMAN
A:
[6-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
-----------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
---
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-------------------------------------------------
42
Blastp_CBE
84.06
85%
-139
- C4 -
-
2Q0B
1
FGFR2_HUMAN
A:
[24-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
-----
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
------------------
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
--------------------------------------------------
21
Blastp_CBE
84.06
79%
-121
- C4 -
-
5A46
2
B:
[22-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
--------------
H
N
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
5
PsiBlast_PDB
84.06
84%
-127
- C4 -
-
3CLY
1
FGFR2_HUMAN
A:
[24-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
-------------------
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
E
E
Y
L
D
L
-------------------------------------------
134
Blastp_CBE
84.02
83%
-144
- C4 -
-
4F64
3
FGFR1_HUMAN
A:
[8-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
-----------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------
129
Blastp_CBE
84.00
83%
-134
- C4 -
-
4NK9
2
B:
[4-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
---------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
--------
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
558
HHSearch
83.97
83%
-124
- C4 -
-
5A46
2
B:
[29-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
--------------
H
N
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
152
Blastp_CBE
83.95
83%
-138
- C4 -
-
6P68
1
C:
[7-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
-----------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
---
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-------------------------------------------------
67
Blastp_CBE
83.95
83%
-131
- C4 -
-
4RWL
1
B:
[10-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
---
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
--------------------
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
------------------------------------------------
130
Blastp_CBE
83.89
83%
-138
- C4 -
-
4NK9
5
FGFR1_HUMAN
A:
[8-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
-
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
--------------------
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
-------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
84
Blastp_CBE
83.85
83%
-141
- C4 -
-
1AGW
1
FGFR1_HUMAN
A:
[9-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
-----------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------
28
Blastp_CBE
83.84
85%
-128
- C4 -
-
4J97
1
?
C:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
---
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
-----
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
------------
I
N
R
V
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
35
Blastp_CBE
83.80
85%
-135
- C4 -
-
2PVY
1
?
C:
[18-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
-----
G
M
E
-------
V
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
--
Y
Y
K
---
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
153
Blastp_CBE
83.77
83%
-140
- C4 -
-
6P68
1
FGFR1_HUMAN
B:
[6-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
------------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
---
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-------------------------------------------------
14
PsiBlast_PDB
83.72
84%
-134
- C4 -
-
2PZP
1
FGFR2_HUMAN
A:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
E
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
------------------
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------------
62
Blastp_CBE
83.64
83%
-138
- C4 -
-
6NVL
1
FGFR1_HUMAN
A:
[7-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
---------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--------
Y
Y
K
K
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
53
Blastp_CBE
83.64
84%
-132
- C4 -
-
5UHN
1
FGFR2_HUMAN
A:
[25-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
-------------------
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
128
Blastp_CBE
83.58
83%
-137
- C4 -
-
4NKA
3
FGFR1_HUMAN
A:
[8-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
----
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
-----------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
-------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
30
Blastp_CBE
83.52
85%
-140
- C4 -
-
4J95
2
?
D:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
-----------------------
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
-----------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
44
Blastp_CBE
83.51
85%
-133
- C4 -
-
2PZ5
1
FGFR2_HUMAN
A:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
T
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
------------------
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------------
34
Blastp_CBE
83.50
85%
-137
- C4 -
-
2PVY
1
?
D:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
-----
G
---------
V
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
8
PsiBlast_PDB
83.50
85%
-126
- C4 -
-
1OEC
1
A:
[15-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
----
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
----------------------
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
192
Blastp_CBE
83.48
78%
-137
- C4 -
-
4XCU
1
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
-
P
-
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
A
R
P
D
Q
A
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
P
-----
G
---------
S
S
E
--
G
P
----
L
S
F
P
V
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
S
--------------------------------------------------
47
Blastp_CBE
83.47
85%
-132
- C4 -
-
2PY3
1
FGFR2_HUMAN
A:
[24-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
----
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
------------------
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
-------------------------------------------------
136
Blastp_CBE
83.46
83%
-142
- C4 -
-
4F63
3
FGFR1_HUMAN
A:
[8-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
-----------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------
158
Blastp_CBE
83.43
83%
-140
- C4 -
-
5ZV2
1
B:
[2-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
------------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-------
D
Y
Y
K
K
T
---
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-------------------------------------------------
54
Blastp_CBE
83.39
84%
-133
- C4 -
-
5UGX
1
B:
[24-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
-----
G
M
-----
I
N
R
V
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
V
----------
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
141
Blastp_CBE
83.33
83%
-127
- C4 -
-
5A4C
7
B:
[3-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
---
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
--------------------
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
-----
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
48
Blastp_CBE
83.32
85%
-145
- C4 -
-
5UGL
1
?
B:
[23-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
---------------------------
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
V
I
-----------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
12
PsiBlast_PDB
83.29
84%
-136
- C4 -
-
2PZR
1
FGFR2_HUMAN
A:
[24-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
-----------------
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
R
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
--------------------------------------------------
92
Blastp_CBE
83.20
83%
-132
- C4 -
-
6C1C
1
FGFR1_HUMAN
A:
[11-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
---------
S
Y
N
P
S
H
N
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
137
Blastp_CBE
83.15
83%
-133
- C4 -
-
4RWK
1
B:
[11-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
-----------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
-----
I
D
Y
Y
K
K
T
--
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-------------------------------------------------
179
Blastp_CBE
83.07
78%
-162
- C4 -
-
5NWZ
1
B:
[8-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
-
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
A
R
P
D
Q
A
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
P
---------------------
P
----
L
S
F
P
V
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
-----------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
S
E
-------------------------------------------------
119
Blastp_CBE
83.07
83%
-136
- C4 -
-
4V01
6
B:
[5-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
V
L
A
E
A
I
G
L
-
D
---
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
----------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
--------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-------------------------------------------------
80
Blastp_CBE
83.00
83%
-143
- C4 -
-
2FGI
1
FGFR1_HUMAN
A:
[9-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
---------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
-
D
I
H
H
I
D
Y
Y
K
K
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------
98
Blastp_CBE
82.96
83%
-133
- C4 -
-
6C18
1
FGFR1_HUMAN
A:
[11-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
----
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
---
S
Y
N
P
S
H
N
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
131
Blastp_CBE
82.83
83%
-137
- C4 -
-
4F65
4
B:
[4-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
---
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
----------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
-------
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-------------------------------------------------
181
Blastp_CBE
82.81
78%
-164
- C4 -
-
5NUD
1
B:
[6-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
L
P
L
D
-
P
-
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
A
R
P
D
Q
A
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
P
---------------------
P
----
L
S
F
P
V
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
------------------
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
---------------------------------------------------
132
Blastp_CBE
82.78
83%
-139
- C4 -
-
4F65
6
FGFR1_HUMAN
A:
[8-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
----------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
----------
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
76
Blastp_CBE
82.77
83%
-137
- C4 -
-
5AM6
1
B:
[3-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
-----------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------
102
Blastp_CBE
82.76
83%
-137
- C4 -
-
5UR1
1
FGFR1_HUMAN
A:
[10-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
-
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
----------
Y
N
P
S
H
N
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
120
Blastp_CBE
82.66
83%
-139
- C4 -
-
4V01
7
FGFR1_HUMAN
A:
[9-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
----
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
---------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
--------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
170
Blastp_CBE
82.53
78%
-146
- C4 -
-
4TYJ
2
A:
[5-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
L
V
S
L
D
L
P
L
D
-
P
-
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
A
R
P
D
Q
A
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
----------------------
P
----
L
S
F
P
V
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
---------------
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
S
E
E
------------------------------------------------
175
Blastp_CBE
82.41
76%
-150
- C4 -
-
4R6V
1
A:
[13-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
L
L
A
G
L
V
S
L
D
L
P
L
D
-
P
-
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
------
D
Q
A
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-
G
P
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
P
--------------------
G
P
----
L
S
F
P
V
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
-----------------
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
---------------------------------------------------
169
Blastp_CBE
82.37
77%
-151
- C4 -
-
4QQC
1
A:
[13-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
L
L
A
G
L
V
S
L
D
L
P
L
D
-
P
-
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
------
D
Q
A
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
P
--------------------
G
P
----
L
S
F
P
V
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
---------------------------------------------------
182
Blastp_CBE
82.26
78%
-159
- C4 -
-
5NUD
1
FGFR4_HUMAN
A:
[7-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
-
P
-
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
A
R
P
D
Q
A
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
----------------------
P
----
L
S
F
P
V
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
-----------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
S
E
E
------------------------------------------------
188
Blastp_CBE
82.23
78%
-149
- C4 -
-
6NVJ
1
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
-
P
-
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
A
R
P
D
Q
A
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
P
-----
G
---------
S
S
E
--
G
P
----
L
S
F
P
V
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
S
--------------------------------------------------
190
Blastp_CBE
82.24
78%
-152
- C4 -
-
6NVH
1
A:
[5-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
-
P
-
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
A
R
P
D
Q
A
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
P
-----
G
---------
S
S
E
--
G
P
----
L
S
F
P
V
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
---------------
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
---------------------------------------------------
90
Blastp_CBE
82.23
83%
-132
- C4 -
-
6C1O
1
FGFR1_HUMAN
A:
[10-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
----------
Y
N
P
S
H
N
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
94
Blastp_CBE
82.16
83%
-150
- C4 -
-
6C1B
1
FGFR1_HUMAN
A:
[11-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
------------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
86
Blastp_CBE
82.15
83%
-136
- C4 -
-
6MZQ
1
FGFR1_HUMAN
A:
[10-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
L
E
Y
S
Y
N
P
S
---
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
-
Q
E
-----------------------------------------------
81
Blastp_CBE
82.11
83%
-145
- C4 -
-
1FGI
1
B:
[6-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
-----------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------
133
Blastp_CBE
82.03
83%
-140
- C4 -
-
4F64
3
B:
[5-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
-----------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------
180
Blastp_CBE
82.01
78%
-158
- C4 -
-
5NWZ
1
FGFR4_HUMAN
A:
[8-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
D
-
P
-
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
A
R
P
D
Q
A
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
P
-----
G
P
D
L
------------
P
----
L
S
F
P
V
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
S
E
-------------------------------------------------
52
Blastp_CBE
81.89
84%
-137
- C4 -
-
5UHN
2
B:
[25-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
-----------------------
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
-----------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
96
Blastp_CBE
81.84
83%
-135
- C4 -
-
6C19
1
FGFR1_HUMAN
A:
[10-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
----
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-------
E
Y
S
Y
N
P
S
---
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
178
Blastp_CBE
81.82
77%
-160
- C4 -
-
6IUO
1
?
A:
[15-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
G
L
V
S
L
D
L
P
L
D
-
P
-
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
---
A
R
P
D
Q
A
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
P
--------------------
G
P
----
L
S
F
P
V
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
---------------------------------------------------
83
Blastp_CBE
81.82
83%
-141
- C4 -
-
1AGW
1
B:
[6-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
-----------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------
114
Blastp_CBE
81.78
83%
-132
- C4 -
-
4WUN
1
FGFR1_HUMAN
A:
[11-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
------
L
E
Y
S
Y
N
P
S
H
N
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
57
Blastp_CBE
81.75
82%
-136
- C4 -
-
3GQL
1
FGFR1_HUMAN
B:
[15-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
----------------
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
135
Blastp_CBE
81.74
83%
-141
- C4 -
-
4F63
3
B:
[5-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
-
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
-----------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------
60
Blastp_CBE
81.73
83%
-153
- C4 -
-
6NVL
1
FGFR1_HUMAN
C:
[9-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
-
D
---
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
--
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
---------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
----
H
H
I
D
Y
Y
K
K
T
-----
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------
56
Blastp_CBE
81.62
82%
-142
- C4 -
-
3GQL
1
C:
[15-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
--------------------
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
Y
----------------------------------------------
101
Blastp_CBE
81.59
83%
-150
- C4 -
-
5UR1
1
B:
[10-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
----------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-------------------------------------------------
176
Blastp_CBE
81.56
76%
-150
- C4 -
-
4QQ5
1
A:
[12-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
P
L
L
A
G
L
V
S
L
D
L
P
L
D
-
P
-
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
------
D
Q
A
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-
G
P
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
P
--------------------
G
P
----
L
S
F
P
V
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
---------------------------------------------------
64
Blastp_CBE
81.46
83%
-131
- C4 -
-
6MZW
1
FGFR1_HUMAN
A:
[10-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
L
E
Y
S
Y
N
P
S
--
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
125
Blastp_CBE
81.39
83%
-138
- C4 -
-
4NKS
1
B:
[5-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
-
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
-----------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------
191
Blastp_CBE
81.33
78%
-153
- C4 -
-
6NVG
1
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
-
P
-
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
A
R
P
D
Q
A
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
P
-----
G
---------
S
S
E
--
G
P
----
L
S
F
P
V
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
S
--------------------------------------------------
148
Blastp_CBE
81.32
83%
-134
- C4 -
-
3RHX
3
B:
[2-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
-----------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------
85
Blastp_CBE
81.30
83%
-153
- C4 -
-
6MZQ
1
B:
[8-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
------------------------------
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
-------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------
91
Blastp_CBE
81.19
83%
-151
- C4 -
-
6C1C
1
B:
[9-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
-
F
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
----------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-------------------------------------------------
113
Blastp_CBE
81.18
83%
-147
- C4 -
-
4WUN
1
B:
[7-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
----
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
---------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------
167
Blastp_CBE
80.95
77%
-157
- C4 -
-
5XFF
1
A:
[11-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
-
P
-
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
A
R
P
D
Q
A
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-
G
P
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
P
-----
G
P
--------------
P
----
L
S
F
P
V
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
---------------------------------------------------
79
Blastp_CBE
80.94
83%
-135
- C4 -
-
2FGI
1
B:
[6-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
-----------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------
126
Blastp_CBE
80.59
83%
-144
- C4 -
-
4NKS
1
FGFR1_HUMAN
A:
[9-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
--------
N
R
V
T
K
-
V
A
V
K
M
L
K
-
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
---------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------
65
Blastp_CBE
80.57
83%
-138
- C4 -
-
3TT0
4
B:
[52-356]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
-----------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
-----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-------------------------------------------------
59
Blastp_CBE
80.54
83%
-140
- C4 -
-
6NVL
1
D:
[15-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
K
--------
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
--
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-----
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
L
E
Y
S
Y
N
P
S
H
N
P
E
--
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
---------
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------
104
Blastp_CBE
80.50
83%
-148
- C4 -
-
5UQ0
1
FGFR1_HUMAN
A:
[10-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
--
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
--
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
---------------------
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
--
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-----------------------------------------------
63
Blastp_CBE
80.45
83%
-156
- C4 -
-
6MZW
1
B:
[9-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
----------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
--------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------
189
Blastp_CBE
80.30
78%
-151
- C4 -
-
6NVI
1
A:
[5-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
-
P
-
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
----
Q
V
V
R
A
E
A
F
G
M
-
D
P
A
R
P
D
Q
A
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
P
----------------
S
E
--
G
P
----
L
S
F
P
V
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
-------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
---------------------------------------------------
95
Blastp_CBE
80.22
83%
-142
- C4 -
-
6C19
1
B:
[10-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
----------------------
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------
61
Blastp_CBE
80.17
83%
-151
- C4 -
-
6NVL
1
FGFR1_HUMAN
B:
[5-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
-------
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
P
-----
G
L
-------------
E
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
---------------------------------------------------
187
Blastp_CBE
80.06
78%
-151
- C4 -
-
6NVK
1
A:
[5-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
-
P
-
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
A
R
P
D
Q
A
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
P
-----
G
---------
S
S
E
--
G
P
----
L
S
F
P
V
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
---------------------------------------------------
171
Blastp_CBE
80.03
78%
-134
- C4 -
-
4TYI
1
A:
[5-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
L
V
S
L
D
L
P
L
D
-
P
-
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
A
R
P
D
Q
A
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
P
---------------------
P
----
L
S
F
P
V
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
--------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
---------------------------------------------------
166
Blastp_CBE
79.65
77%
-146
- C4 -
-
5JKG
1
A:
[11-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
-
P
-
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
A
R
P
D
Q
A
S
T
-
V
A
V
K
M
L
K
D
---
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
P
-----
G
P
--------------
P
----
L
S
F
P
V
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
---------------------------------------------------
168
Blastp_CBE
79.57
77%
-153
- C4 -
-
5XFJ
1
A:
[11-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
P
L
D
-
P
-
L
W
E
F
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
A
R
P
D
Q
A
S
T
-
V
A
V
K
M
L
K
D
---
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
-
E
-
G
P
L
Y
V
I
M
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
-
R
P
P
-----
G
P
--------------
P
----
L
S
F
P
V
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
S
L
L
R
E
G
-------
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
---------------------------------------------------
93
Blastp_CBE
79.36
83%
-152
- C4 -
-
6C1B
1
B:
[9-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
---------
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
-----------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------
89
Blastp_CBE
79.32
83%
-145
- C4 -
-
6C1O
1
B:
[10-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
--
F
G
Q
V
V
L
A
E
A
I
G
L
----
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
P
----------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
-------------------------------------------------
97
Blastp_CBE
79.30
83%
-149
- C4 -
-
6C18
1
B:
[12-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
----
G
Q
V
V
L
A
E
A
I
G
L
---
D
K
P
N
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
-----------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
--------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------
103
Blastp_CBE
78.54
83%
-150
- C4 -
-
5UQ0
1
B:
[9-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
P
E
D
-
P
-
R
W
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
-------
R
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-
R
-----------------------
Q
----
L
S
S
K
D
L
V
-------
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
P
V
K
W
M
A
P
E
A
L
--
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
--------------------------------------------------
574
HHSearch
75.60
56%
-125
- C4 -
-
6FEK
3
A:
[15-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
P
-
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
--
R
A
G
Y
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
-
R
K
V
-----
G
P
-------
G
P
D
E
--
R
A
----
L
T
M
G
D
L
I
-------
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
F
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
-----------------------------------------------------
293
Blastp_CBE
75.21
50%
-100
- C4 -
-
6HH1
1
?
A:
[1-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
N
Y
V
Y
I
D
P
T
Q
L
P
Y
D
-
H
-
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
-
I
K
S
D
A
A
--
M
T
-
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
D
S
-----
F
I
--
C
S
K
T
S
P
A
I
E
--
L
A
----
L
D
L
E
D
L
L
-------
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
-----------------------------------------------------
258
Blastp_CBE
74.86
48%
-95
- C4 -
-
6GQK
1
?
A:
[21-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
S
Y
I
D
P
T
Q
L
P
Y
D
-
H
-
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
G
L
-
I
K
S
D
A
A
--
M
T
-
V
A
V
K
M
L
K
P
S
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
D
E
-----
F
V
P
Y
K
V
A
P
E
D
L
Y
K
--
D
F
----
L
T
L
E
H
L
L
-------
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
N
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
K
Q
I
S
E
S
---------------------------------------------------
163
Blastp_CBE
74.72
86%
-84
- C4 -
-
6AGX
1
?
C:
[1-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
--------------
N
R
V
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
-----
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
202
Blastp_CBE
74.66
52%
-110
- C4 -
-
3KRJ
1
A:
[14-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
W
K
I
I
E
S
Y
E
G
N
S
Y
T
F
I
D
P
T
Q
L
P
Y
N
-
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
-
G
K
E
D
A
V
--
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
P
P
-----
G
---------------
Q
----
L
S
S
R
D
L
L
-------
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
----------------------------------------------------------
254
Blastp_CBE
74.62
48%
-100
- C4 -
-
6GQM
2
A:
[23-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
I
D
P
T
Q
L
P
Y
D
-
H
-
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
G
L
-
I
K
S
D
A
A
--
M
T
-
V
A
V
K
M
L
K
P
S
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
D
E
-----
F
V
P
Y
------
L
Y
K
--
D
F
----
L
T
L
E
H
L
L
-------
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
N
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
K
Q
I
S
E
S
---------------------------------------------------
292
Blastp_CBE
74.31
49%
-107
- C4 -
-
6T2W
1
?
A:
[7-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
W
K
I
I
E
S
Y
--
N
S
Y
T
F
I
D
P
T
Q
L
P
Y
N
-
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
-
G
K
E
D
A
V
--
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
A
E
A
-----
M
L
-------------
R
P
----
L
E
L
R
D
L
L
-------
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
----------------------------------------------------------
206
Blastp_CBE
74.29
52%
-123
- C4 -
-
6NEC
2
C:
[1-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
S
L
S
V
D
A
F
K
I
L
E
D
-
P
-
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
--
K
G
R
A
G
Y
-
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
-
R
K
V
-----------------
E
--
R
A
----
L
T
M
G
D
L
I
-------
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
---------
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
-----------------------------------------------------
256
Blastp_CBE
74.11
48%
-98
- C4 -
-
6GQL
1
KIT_HUMAN
A:
[22-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
S
Y
I
D
P
T
Q
L
P
Y
D
-
H
-
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
G
L
-
I
K
S
D
A
A
--
M
T
-
V
A
V
K
M
L
K
P
S
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
D
E
-----
F
V
P
Y
------
L
Y
K
--
D
F
----
L
T
L
E
H
L
L
-------
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
N
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
K
Q
I
S
E
S
---------------------------------------------------
209
Blastp_CBE
73.63
52%
-121
- C4 -
-
2IVS
5
RET_HUMAN
A:
[14-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
P
-
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
--
K
G
R
A
G
Y
-
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
-
R
K
V
-----
G
P
G
Y
L
----------
R
A
----
L
T
M
G
D
L
I
-------
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
-----------------------------------------------------
204
Blastp_CBE
73.52
52%
-116
- C4 -
-
2I0Y
1
?
A:
[14-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
W
K
I
I
E
S
Y
E
--
S
Y
T
F
I
---------
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
-
G
K
E
D
A
V
--
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
-----------------------
Q
----
L
S
S
R
D
L
L
-------
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
----------------------------------------------------------
269
Blastp_CBE
73.35
48%
-43
- C4 -
-
4HVS
1
A:
[14-332]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
W
K
V
V
E
E
S
N
G
N
N
Y
S
Y
I
D
P
T
Q
L
P
Y
D
-
H
-
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
G
L
-
I
K
S
D
A
A
--
M
T
-
V
A
V
K
M
L
K
P
S
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
D
S
FH---
S
S
D
T
S
P
A
S
M
E
D
D
E
--
N
A
----
L
D
L
E
D
L
L
-------
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
S
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
K
Q
I
S
E
S
---------------------------------------------------
205
Blastp_CBE
73.26
52%
-108
- C4 -
-
2I0V
1
A:
[14-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
W
K
I
I
E
S
Y
E
G
N
S
Y
T
F
I
D
P
T
Q
L
P
Y
N
-
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
-
G
K
E
D
A
V
--
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
-----------------------
Q
----
L
S
S
R
D
L
L
-------
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
----------------------------------------------------------
165
Blastp_CBE
73.09
86%
-79
- C4 -
-
6AGX
1
FGFR2_HUMAN
A:
[1-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
-------------
I
N
R
V
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
-----
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
261
Blastp_CBE
72.89
48%
-95
- C4 -
-
6GQJ
1
?
A:
[21-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
S
Y
I
D
P
T
Q
L
P
Y
D
-
H
-
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
G
L
-
I
K
S
D
A
A
--
M
T
-
V
A
V
K
M
L
K
P
S
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
D
E
-----
F
V
P
Y
K
-------
K
--
D
F
----
L
T
L
E
H
L
L
-------
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
N
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
K
Q
I
S
E
S
---------------------------------------------------
207
Blastp_CBE
72.88
52%
-116
- C4 -
-
6NEC
3
RET_HUMAN
A:
[14-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-
P
-
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
--
K
G
R
A
G
Y
-
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
-
R
K
V
-----
G
P
G
Y
L
G
-----
D
E
--
R
A
----
L
T
M
G
D
L
I
-------
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
-----------------------------------------------------
201
Blastp_CBE
72.84
52%
-122
- C4 -
-
3KRL
1
A:
[14-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
W
K
I
I
----------------
P
Y
N
-
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
-
G
K
E
D
A
V
--
L
K
-
V
A
V
K
M
L
K
S
T
A
-
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
-----------------------
Q
----
L
S
S
R
D
L
L
-------
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
----------------------------------------------------------
291
Blastp_CBE
72.67
49%
-118
- C4 -
-
3LCD
1
?
A:
[24-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
S
Y
T
F
I
D
P
T
Q
L
P
Y
N
-
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
-
G
K
E
D
A
V
--
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
A
E
A
-----
D
L
D
-------------
P
----
L
E
L
R
D
L
L
-------
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
--
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
----------------------------------------------------------
575
HHSearch
72.46
55%
-125
- C4 -
-
4CKJ
16
A:
[16-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
--
R
A
G
Y
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
-
R
K
V
--------------------
R
A
----
L
T
M
G
D
L
I
-------
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
-----------------------------------------------------
208
Blastp_CBE
72.45
52%
-130
- C4 -
-
2IVS
4
B:
[1-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
S
L
S
V
D
A
F
K
I
----
P
-
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
--
K
G
R
A
G
Y
-
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
-
R
K
---------------------
R
A
----
L
T
M
G
D
L
I
-------
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
-----------
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
-----------------------------------------------------
260
Blastp_CBE
72.41
48%
-95
- C4 -
-
6GQJ
1
?
B:
[26-325]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
L
P
Y
D
-
H
-
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
G
L
-
I
K
S
D
A
A
--
M
T
-
V
A
V
K
M
L
K
P
S
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
D
E
-----
F
V
P
--------
Y
K
--
D
F
----
L
T
L
E
H
L
L
-------
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
N
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
K
Q
I
S
E
S
---------------------------------------------------
257
Blastp_CBE
72.18
48%
-99
- C4 -
-
6GQK
1
?
B:
[26-325]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
L
P
Y
D
-
H
-
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
G
L
-
I
K
S
D
A
A
--
M
T
-
V
A
V
K
M
L
K
P
S
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
D
E
-----
F
V
P
Y
K
V
---------
D
F
----
L
T
L
E
H
L
L
-------
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
N
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
K
Q
I
S
E
S
---------------------------------------------------
255
Blastp_CBE
71.91
48%
-102
- C4 -
-
6GQL
1
KIT_HUMAN
B:
[31-325]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
-
H
-
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
G
L
-
I
K
S
D
A
A
--
M
T
-
V
A
V
K
M
L
K
P
S
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
D
E
-----
F
V
P
Y
K
-----------
F
----
L
T
L
E
H
L
L
-------
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
N
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
K
Q
I
S
E
S
---------------------------------------------------
295
Blastp_CBE
71.78
49%
-76
- C4 -
-
3BEA
1
A:
[14-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
W
K
I
I
E
S
Y
E
G
N
S
Y
T
F
I
D
P
T
Q
L
P
Y
N
-
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
-
G
K
E
D
A
V
--
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
S
R
V
L
--------------------
S
T
----
L
S
T
R
D
L
L
-------
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
----------------------------------------------------------
567
HHSearch
71.73
56%
-56
- C4 -
-
4ASD
1
A:
[58-349]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
--
T
A
T
C
R
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
-------
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
E
F
C
-
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
---------------------------------------------------
253
Blastp_CBE
71.55
48%
-101
- C4 -
-
6GQM
1
?
B:
[31-325]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
-
H
-
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
G
L
-
I
K
S
D
A
A
--
M
T
-
V
A
V
K
M
L
K
P
S
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
D
E
-----
F
V
P
Y
K
-------
K
--
D
F
----
L
T
L
E
H
L
L
-------
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
N
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
S
S
P
E
Y
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
K
Q
I
S
E
S
---------------------------------------------------
560
HHSearch
71.38
55%
-130
- C4 -
-
5FM3
1
A:
[57-352]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
--
R
A
G
Y
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
-------------------------
A
----
L
T
M
G
D
L
I
-------
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
-----------------------------------------------------
162
Blastp_CBE
71.13
86%
-53
- C4 -
-
6AGX
1
?
D:
[1-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
-----
G
M
E
S
S
-
D
I
N
R
V
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
572
HHSearch
71.04
56%
-56
- C4 -
-
4ASE
1
A:
[58-348]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
--
T
A
T
C
R
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
-
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
-------
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
E
F
C
-
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
----------------------------------------------------
203
Blastp_CBE
70.85
52%
-116
- C4 -
-
3DPK
1
A:
[14-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
W
K
I
I
E
S
----
S
Y
T
F
I
D
----
P
Y
N
-
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
-
G
---
A
V
--
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
--------------------------
Q
----
L
S
S
R
D
L
L
-------
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
----
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
----------------------------------------------------------
164
Blastp_CBE
70.48
86%
-51
- C4 -
-
6AGX
1
B:
[1-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
-
P
-
K
W
E
F
P
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
D
K
P
K
E
A
V
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
-
D
-
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
-
R
P
P
-----
G
M
E
S
S
-
D
I
N
R
V
P
E
--
E
Q
----
M
T
F
K
D
L
V
-------
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
-
E
-
L
F
-
K
L
L
K
E
G
-------
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
---------------------------------------------------
309
Blastp_CBE
70.27
49%
-69
- C4 -
-
2I1M
1
A:
[14-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
W
K
I
I
E
S
Y
--
N
S
Y
T
F
I
D
P
T
Q
L
P
Y
N
-
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
-
G
K
E
D
A
V
--
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
S
R
V
L
-----
E
T
D
-------
S
T
A
--
S
T
-------
R
D
L
L
-------
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
----------------------------------------------------------
214
Blastp_CBE
69.93
54%
-13
- C4 -
-
6GQO
1
A:
[15-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
V
A
P
E
D
L
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------
300
Blastp_CBE
69.91
49%
-71
- C4 -
-
6IG8
2
?
A:
[1-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
S
Y
E
----
T
F
I
D
P
T
Q
L
P
Y
N
-
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
-
G
K
E
D
A
V
--
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
A
E
A
-----
M
L
G
P
S
L
-------G-
R
P
----
L
E
L
R
D
L
L
-------
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
----------------------------------------------------------
289
Blastp_CBE
69.86
49%
-72
- C4 -
-
4R7H
1
A:
[18-334]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
W
K
I
I
E
-----
S
Y
T
F
I
D
P
T
Q
L
P
Y
N
-
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
-
G
K
E
D
A
V
--
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
R
K
-
A
E
A
-----
M
L
G
P
S
L
-------G-
R
P
----
L
E
L
R
D
L
L
-------
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
F
L
----------------------------------------------------------
226
Blastp_CBE
69.37
54%
-13
- C4 -
-
3VNT
4
A:
[17-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
------
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------
287
Blastp_CBE
69.36
49%
-63
- C4 -
-
6N33
1
A:
[36-334]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
L
P
Y
N
-
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
-
G
K
E
D
A
V
--
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
R
K
-
A
E
A
-----
M
L
G
P
S
L
S
------G-
R
P
----
L
E
L
R
D
L
L
-------
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
F
L
----------------------------------------------------------
290
Blastp_CBE
69.35
49%
-69
- C4 -
-
4HW7
1
A:
[36-334]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
L
P
Y
N
-
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
-
G
K
E
D
A
V
--
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
R
K
-
A
E
A
-----
M
L
G
P
S
--------G-
R
P
----
L
E
L
R
D
L
L
-------
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
F
L
----------------------------------------------------------
305
Blastp_CBE
69.30
48%
-64
- C4 -
-
6KLA
1
?
A:
[18-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
N
N
Y
V
Y
I
D
P
T
Q
L
P
Y
D
-
H
-
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
-
I
K
S
D
A
A
--
M
T
-
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
D
----------
S
-----------------
E
D
D
E
L
A
LDLEDLL
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
-----------------------------------------------------
288
Blastp_CBE
69.18
49%
-70
- C4 -
-
4R7I
1
?
A:
[37-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
L
P
Y
N
-
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
-
G
K
E
D
A
V
--
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
R
K
-
A
E
A
-----
M
L
G
P
S
L
S
------G-
R
P
----
L
E
L
R
D
L
L
-------
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
F
L
----------------------------------------------------------
557
Blastp_CBE
69.17
38%
-129
- C4 -
-
1OPK
3
ABL1_MOUSE
A:
[203-484]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
I
Y
G
V
S
----
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
297
Blastp_CBE
69.16
50%
-112
- C4 -
-
4XUF
1
FLT3_HUMAN
A:
[1-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
L
-
K
W
E
F
P
R
E
N
L
E
F
G
K
V
L
G
S
G
A
F
G
K
V
M
N
A
T
A
Y
G
I
-
S
K
T
G
V
S
--
I
Q
-
V
A
V
K
M
L
K
E
---
S
S
E
R
E
A
L
M
S
E
L
K
M
M
T
Q
L
G
S
H
E
N
I
V
N
L
L
G
A
C
T
-
L
-
S
-
G
P
I
Y
L
I
F
E
Y
C
C
Y
G
D
L
L
N
Y
L
R
S
K
-
R
----------------------------
L
T
F
E
D
L
L
-------
C
F
A
Y
Q
V
A
K
G
M
E
F
L
E
F
K
S
C
V
H
R
D
L
A
A
R
N
V
L
V
T
---
H
G
K
V
V
K
I
C
D
F
G
L
A
R
D
I
M
S
D
S
N
Y
V
V
R
G
N
A
R
L
P
V
K
W
M
A
P
E
S
L
F
E
G
I
Y
T
I
K
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
V
N
P
Y
P
G
I
P
V
D
A
N
-
F
Y
-
K
L
I
Q
N
G
-------
F
K
M
D
Q
P
F
Y
A
T
E
E
I
Y
I
I
M
Q
S
C
W
A
F
D
S
R
K
R
P
S
F
P
N
L
T
S
F
L
----------------------------------------------------------
299
Blastp_CBE
69.13
48%
-56
- C4 -
-
1T46
1
?
A:
[1-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
N
Y
V
Y
I
D
P
T
Q
L
P
Y
D
-
H
-
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
-
I
K
S
D
A
A
--
M
T
-
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
D
----------
S
F
--------------------
L
A
LDLEDLL
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
-----------------------------------------------------
312
Blastp_CBE
68.89
50%
-64
- C4 -
-
6ITV
1
?
A:
[29-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
-
H
-
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
-
I
K
S
D
A
A
--
M
T
-
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
D
----------
S
-----------------
E
D
D
E
L
A
LDLEDLL
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
-----------------------------------------------------
304
Blastp_CBE
68.87
50%
-62
- C4 -
-
6MOB
1
KIT_HUMAN
A:
[10-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
-
H
-
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
-
I
K
S
D
A
A
--
M
T
-
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
D
----------
S
F
I
C
S
K
T
S
P
--
A
I
----
M
E
D
D
E
L
A
LDLEDLL
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
-----------------------------------------------------
484
Blastp_CBE
68.82
38%
-134
- C4 -
-
3K5V
2
ABL1_MOUSE
A:
[8-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
-
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
212
Blastp_CBE
68.82
54%
-15
- C4 -
-
6GQQ
1
A:
[15-312]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
V
A
P
E
D
L
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
---------------------------------------------------
474
Blastp_CBE
68.75
38%
-137
- C4 -
-
6HD6
2
ABL1_MOUSE
A:
[8-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
--
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
314
Blastp_CBE
68.75
48%
-72
- C4 -
-
3G0F
1
?
A:
[25-330]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
Y
V
Y
I
D
P
T
Q
L
P
Y
D
-
H
-
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
-
I
K
S
D
A
A
--
M
T
-
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
D
----------
S
F
----------------------LDLEDLL
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
H
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
-----------------------------------------------------
313
Blastp_CBE
68.73
48%
-71
- C4 -
-
3G0F
1
?
B:
[23-330]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
N
N
Y
V
Y
I
D
P
T
Q
L
P
Y
D
-
H
-
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
-
I
K
S
D
A
A
--
M
T
-
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
D
----------
S
F
----------------------LDLEDLL
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
H
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
-----------------------------------------------------
476
Blastp_CBE
68.67
38%
-135
- C4 -
-
6HD4
3
ABL1_MOUSE
A:
[8-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
-
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
511
Blastp_CBE
68.60
38%
-133
- C4 -
-
2G1T
1
ABL1_HUMAN
B:
[5-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------
417
Blastp_CBE
68.63
38%
-129
- C4 -
-
3IK3
1
ABL1_MOUSE
B:
[3-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
225
Blastp_CBE
68.60
54%
-13
- C4 -
-
3VO3
2
A:
[17-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
----
D
L
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------
416
Blastp_CBE
68.58
38%
-125
* C4 *
-
3OY3
1
ABL1_MOUSE
A:
[3-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
220
Blastp_CBE
68.54
54%
-14
- C4 -
-
4ASD
1
A:
[52-350]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
-------
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------
218
Blastp_CBE
68.49
54%
-17
- C4 -
-
2XIR
1
A:
[15-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
-------
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------
217
Blastp_CBE
68.44
54%
-17
- C4 -
-
4AG8
1
A:
[15-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
-------
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------
488
Blastp_CBE
68.43
38%
-131
- C4 -
-
1M52
3
ABL1_MOUSE
B:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
------------------------------------------------
470
Blastp_CBE
68.40
38%
-130
- C4 -
-
2QOH
1
ABL1_MOUSE
B:
[3-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
---
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
301
Blastp_CBE
68.39
49%
-66
- C4 -
-
3LCO
1
A:
[2-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
Y
T
F
I
D
P
T
Q
L
P
Y
N
-
E
-
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
-
G
K
E
D
A
V
--
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
-
H
-
G
-
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
A
E
A
-----
M
L
G
P
S
--------G-
R
P
----
L
E
L
R
D
L
L
-------
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
----
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
-
F
Y
-
K
L
V
K
D
G
-------
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
----------------------------------------------------------
219
Blastp_CBE
68.38
54%
-18
- C4 -
-
4ASE
1
A:
[52-350]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
-------
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------
486
Blastp_CBE
68.37
38%
-133
- C4 -
-
1OPJ
2
ABL1_MOUSE
B:
[8-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
303
Blastp_CBE
68.35
49%
-76
- C4 -
-
6IL3
12
A:
[59-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
Y
D
-
L
-
K
W
E
F
P
R
E
N
L
E
F
G
K
V
L
G
S
G
A
F
G
K
V
M
N
A
T
A
Y
G
I
-
S
K
--
T
G
V
S
I
Q
-
V
A
V
K
M
L
K
E
K
A
D
S
S
E
R
E
A
L
M
S
E
L
K
M
M
T
Q
L
G
S
H
E
N
I
V
N
L
L
G
A
C
T
-
L
-
S
-
G
P
I
Y
L
I
F
E
Y
C
C
Y
G
D
L
L
N
Y
L
R
S
K
-
R
E
K
-----
F
S
---------------NV--
L
T
F
E
D
L
L
-------
C
F
A
Y
Q
V
A
K
G
M
E
F
L
E
F
K
S
C
V
H
R
D
L
A
A
R
N
V
L
V
T
---
H
G
K
V
V
K
I
C
D
F
G
L
A
R
D
I
M
S
D
S
N
Y
V
V
R
G
N
A
R
L
P
V
K
W
M
A
P
E
S
L
F
E
G
I
Y
T
I
K
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
V
N
P
Y
P
G
I
P
V
D
A
N
-
F
Y
-
K
L
I
Q
N
G
-------
F
K
M
D
Q
P
F
Y
A
T
E
E
I
Y
I
I
M
Q
S
C
W
A
F
D
S
R
K
R
P
S
F
P
N
L
T
S
F
L
----------------------------------------------------------
224
Blastp_CBE
68.32
54%
-12
- C4 -
-
3U6J
1
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
--
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
V
A
P
E
D
L
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------
210
Blastp_CBE
68.31
54%
-16
- C4 -
-
3WZE
2
A:
[7-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
----
D
L
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
-
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
---------------------------------------------------
538
Blastp_CBE
68.30
39%
-134
- C4 -
-
2HYY
1
ABL1_HUMAN
D:
[6-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
--
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
------------------------------------------------------
509
Blastp_CBE
68.26
38%
-132
- C4 -
-
2G1T
1
ABL1_HUMAN
D:
[5-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------
213
Blastp_CBE
68.22
54%
-19
- C4 -
-
6GQP
1
?
A:
[16-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
V
A
P
E
D
L
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------
298
Blastp_CBE
68.11
48%
-62
- C4 -
-
4U0I
1
A:
[3-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
N
Y
V
Y
I
D
P
T
Q
L
P
Y
D
-
H
-
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
-
I
---
A
A
--
M
T
-
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
D
----------
S
F
I
C
S
-----------------
L
A
LDLEDLL
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
-----------------------------------------------------
501
Blastp_CBE
68.07
38%
-131
- C4 -
-
4XEY
1
ABL1_HUMAN
B:
[96-389]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
V
Y
G
V
S
----
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
------
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
---
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
415
Blastp_CBE
68.03
38%
-125
- C4 -
-
3OY3
1
ABL1_MOUSE
B:
[3-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
222
Blastp_CBE
68.03
54%
-20
- C4 -
-
4AGC
1
A:
[52-350]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
-------
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------
519
Blastp_CBE
68.01
38%
-128
- C4 -
-
2G2H
1
ABL1_HUMAN
A:
[8-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
542
Blastp_CBE
68.00
39%
-132
- C4 -
-
3QRK
1
ABL1_HUMAN
A:
[8-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-------------------------------------------------------
308
Blastp_CBE
67.97
48%
-58
- C4 -
-
3G0E
1
?
A:
[23-330]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
N
N
Y
V
Y
I
D
P
T
Q
L
P
Y
D
-
H
-
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
-
I
K
S
D
A
A
--
M
T
-
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
D
----------
S
F
I
C
S
K
T
S
P
--
A
I
----
M
E
D
D
E
L
A
LDLEDLL
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
-----------------------------------------------------
475
Blastp_CBE
67.93
38%
-134
- C4 -
-
6HD4
2
ABL1_MOUSE
B:
[8-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
---
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
495
Blastp_CBE
67.87
38%
-139
- C4 -
-
4ZOG
2
ABL1_HUMAN
B:
[6-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
--
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
------------------------------------------------
420
Blastp_CBE
67.82
38%
-87
- C4 -
-
5KZ0
1
A:
[26-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
-----------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
------------------------------------
483
Blastp_CBE
67.78
38%
-131
- C4 -
-
3K5V
2
ABL1_MOUSE
B:
[8-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
---
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
307
Blastp_CBE
67.78
48%
-65
- C4 -
-
6ITT
2
?
A:
[18-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
N
N
Y
V
Y
I
D
P
T
Q
L
P
Y
D
-
H
-
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
-
I
K
S
D
A
A
--
M
T
-
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
D
----------
S
-----------------
E
D
D
E
L
A
LDLEDLL
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
-----------------------------------------------------
471
Blastp_CBE
67.64
38%
-132
- C4 -
-
2QOH
1
ABL1_MOUSE
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
---
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
--------------------------------------------------
508
Blastp_CBE
67.63
38%
-125
- C4 -
-
2HIW
1
ABL1_HUMAN
A:
[5-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
----------------------------------------------------
505
Blastp_CBE
67.58
38%
-137
- C4 -
-
3UE4
1
ABL1_HUMAN
B:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
--
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------
467
Blastp_CBE
67.58
38%
-124
- C4 -
-
3KFA
1
ABL1_MOUSE
A:
[3-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
437
Blastp_CBE
67.56
38%
-90
- C4 -
-
4FOD
2
A:
[33-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
---------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
G
P
----------------------------------
461
Blastp_CBE
67.51
39%
-140
- C4 -
-
4TWP
1
ABL1_HUMAN
B:
[2-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
--------------------------------------------------
510
Blastp_CBE
67.52
38%
-131
- C4 -
-
2G1T
1
ABL1_HUMAN
C:
[7-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
302
Blastp_CBE
67.51
49%
-75
- C4 -
-
5X02
1
A:
[36-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
Y
D
-
L
-
K
W
E
F
P
R
E
N
L
E
F
G
K
V
L
G
S
G
A
F
G
K
V
M
N
A
T
A
Y
G
I
-
S
K
--
T
G
V
S
I
Q
-
V
A
V
K
M
L
K
E
K
A
D
S
S
E
R
E
A
L
M
S
E
L
K
M
M
T
Q
L
G
S
H
E
N
I
V
N
L
L
G
A
C
T
-
L
-
S
-
G
P
I
Y
L
I
F
E
Y
C
C
Y
G
D
L
L
N
Y
L
R
S
K
-
R
E
K
-----
F
S
---------------V---
L
T
F
E
D
L
L
-------
C
F
A
Y
Q
V
A
K
G
M
E
F
L
E
F
K
S
C
V
H
R
D
L
A
A
R
N
V
L
V
T
---
H
G
K
V
V
K
I
C
D
F
G
L
A
R
D
I
M
S
D
S
N
Y
V
V
R
G
N
A
R
L
P
V
K
W
M
A
P
E
S
L
F
E
G
I
Y
T
I
K
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
V
N
P
Y
P
G
I
P
V
D
A
N
-
F
Y
-
K
L
I
Q
N
G
-------
F
K
M
D
Q
P
F
Y
A
T
E
E
I
Y
I
I
M
Q
S
C
W
A
F
D
S
R
K
R
P
S
F
P
N
L
T
S
F
L
----------------------------------------------------------
491
Blastp_CBE
67.45
38%
-130
- C4 -
-
1IEP
1
ABL1_MOUSE
A:
[8-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-----------------------------------------------------
552
Blastp_CBE
67.44
39%
-133
- C4 -
-
2HZI
1
ABL1_HUMAN
A:
[10-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
------------------------------------------------------
534
Blastp_CBE
67.39
38%
-138
- C4 -
-
3PYY
1
ABL1_HUMAN
A:
[18-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
----
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
---------------------------------------------------
361
Blastp_CBE
67.42
41%
-111
- C4 -
-
4IBM
1
?
A:
[11-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
G
E
A
E
--
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
S
-
K
-
G
-
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
-
R
P
E
-----
A
E
N
---
N
P
G
R
P
P
P
---------
T
L
Q
E
M
I
-------
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
K
F
V
M
D
G
-------
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
----------------------------------------------------------
506
Blastp_CBE
67.41
38%
-128
- C4 -
-
3UE4
1
ABL1_HUMAN
A:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------
481
Blastp_CBE
67.39
38%
-134
- C4 -
-
3MS9
2
ABL1_MOUSE
B:
[8-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
---
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-----------------------------------------------------
496
Blastp_CBE
67.35
38%
-133
- C4 -
-
4ZOG
5
ABL1_HUMAN
A:
[5-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
--------------------------------------------------
262
Blastp_CBE
67.31
52%
-95
- C4 -
-
4CKJ
17
A:
[1-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
S
L
S
V
D
A
F
K
I
L
E
D
-
P
-
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
--
K
G
R
A
G
Y
-
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
-
R
K
V
--------------------
R
A
----
L
T
M
G
D
L
I
-------
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
-
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
-----------------------------------------------------
466
Blastp_CBE
67.29
38%
-122
- C4 -
-
3KFA
1
ABL1_MOUSE
B:
[3-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
452
Blastp_CBE
67.26
38%
-85
- C4 -
-
4CD0
1
A:
[41-332]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
------------------------------------
419
Blastp_CBE
67.26
38%
-131
- C4 -
-
2Z60
1
ABL1_MOUSE
A:
[3-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
---
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
547
Blastp_CBE
67.23
39%
-132
- C4 -
-
3CS9
1
ABL1_HUMAN
D:
[10-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
--------
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
------------------------------------------------------
424
Blastp_CBE
67.22
38%
-87
- C4 -
-
4CNH
2
B:
[26-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
---P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
S
Y
-----
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
--------------------------------------
459
Blastp_CBE
67.21
38%
-79
- C4 -
-
3LCT
3
A:
[44-334]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
M
-
P
N
D
--
P
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
--------------------------------------
267
Blastp_CBE
67.20
52%
-99
- C4 -
-
2IVU
3
A:
[1-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
S
L
S
V
D
A
F
K
I
L
-
D
-
P
-
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
--
K
G
R
A
G
Y
-
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
-
R
----------------------
R
A
----
L
T
M
G
D
L
I
-------
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
-
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
-----------------------------------------------------
522
Blastp_CBE
67.14
38%
-86
- C4 -
-
4MKC
3
A:
[67-358]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
---------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
------------------------------------
544
Blastp_CBE
67.13
39%
-130
- C4 -
-
3QRI
1
ABL1_HUMAN
A:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
------------------------------------------------------
487
Blastp_CBE
67.16
38%
-128
- C4 -
-
1OPJ
2
ABL1_MOUSE
A:
[8-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
556
Blastp_CBE
67.10
38%
-147
- C4 -
-
5MO4
2
ABL1_HUMAN
A:
[203-484]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
V
Y
G
V
S
----
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
--
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
-------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
426
Blastp_CBE
67.14
38%
-91
- C4 -
-
4CMU
1
A:
[26-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
-----------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
--------------------------------------
512
Blastp_CBE
67.13
38%
-133
- C4 -
-
2G1T
1
ABL1_HUMAN
A:
[7-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------
266
Blastp_CBE
67.10
52%
-99
- C4 -
-
2X2K
4
A:
[1-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
S
L
S
V
D
A
F
K
I
----
P
-
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
--
K
G
R
A
G
Y
-
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
-
R
K
V
--------------------
R
A
----
L
T
M
G
D
L
I
-------
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
-
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
-----------------------------------------------------
473
Blastp_CBE
67.09
38%
-129
- C4 -
-
6HD6
1
ABL1_MOUSE
B:
[8-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
---
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
521
Blastp_CBE
67.07
38%
-125
- C4 -
-
2G2F
1
ABL1_HUMAN
A:
[7-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
440
Blastp_CBE
67.05
38%
-88
- C4 -
-
4CLJ
1
A:
[26-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
------------------------------------
460
Blastp_CBE
67.04
38%
-81
- C4 -
-
3LCS
3
A:
[44-333]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
M
-
P
N
D
--
P
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
---------------------------------------
430
Blastp_CBE
66.99
38%
-88
- C4 -
-
4CCU
1
A:
[26-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
-----------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
------------------------------------
268
Blastp_CBE
67.01
52%
-95
- C4 -
-
2IVT
3
A:
[1-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
S
L
S
V
D
A
F
K
I
----
P
-
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
--
K
G
R
A
G
Y
-
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
-
R
K
V
--------------------
R
A
----
L
T
M
G
D
L
I
-------
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
-
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
-----------------------------------------------------
428
Blastp_CBE
66.99
38%
-90
- C4 -
-
4CMO
1
A:
[26-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
-----------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
------------------------------------
540
Blastp_CBE
66.96
39%
-129
- C4 -
-
2HYY
1
ABL1_HUMAN
B:
[6-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
-
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
------------------------------------------------------
515
Blastp_CBE
66.90
38%
-126
- C4 -
-
2F4J
1
ABL1_HUMAN
A:
[4-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
429
Blastp_CBE
66.90
38%
-87
- C4 -
-
4CLI
1
A:
[26-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
-----------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
--------------------------------------
404
Blastp_CBE
66.84
39%
-88
- C4 -
-
4ANS
1
A:
[41-332]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
Q
V
-----------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
------------------------------------
489
Blastp_CBE
66.80
38%
-130
- C4 -
-
1M52
1
ABL1_MOUSE
A:
[10-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------
296
Blastp_CBE
66.80
50%
-61
- C4 -
-
4XUF
1
B:
[1-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
L
-
K
W
E
F
P
R
E
N
L
E
F
G
K
V
L
G
S
G
A
F
G
K
V
M
N
A
T
A
Y
G
I
-
S
K
T
G
V
S
--
I
Q
-
V
A
V
K
M
L
K
E
K
A
D
S
S
E
R
E
A
L
M
S
E
L
K
M
M
T
Q
L
G
S
H
E
N
I
V
N
L
L
G
A
C
T
-
L
-
S
-
G
P
I
Y
L
I
F
E
Y
C
C
Y
G
D
L
L
N
Y
L
R
S
K
-
R
------------------------NV--
L
T
F
E
D
L
L
-------
C
F
A
Y
Q
V
A
K
G
M
E
F
L
E
F
K
S
C
V
H
R
D
L
A
A
R
N
V
L
V
T
---
H
G
K
V
V
K
I
C
D
F
G
L
A
R
D
I
M
S
D
S
N
Y
V
V
R
G
N
A
R
L
P
V
K
W
M
A
P
E
S
L
F
E
G
I
Y
T
I
K
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
V
N
P
Y
P
G
I
P
V
D
A
N
-
F
Y
-
K
L
I
Q
N
G
-------
F
K
M
D
Q
P
F
Y
A
T
E
E
I
Y
I
I
M
Q
S
C
W
A
F
D
S
R
K
R
P
S
F
P
N
L
T
S
F
L
----------------------------------------------------------
518
Blastp_CBE
66.74
38%
-131
- C4 -
-
2G2H
1
ABL1_HUMAN
B:
[8-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
402
Blastp_CBE
66.75
38%
-89
- C4 -
-
5AAB
1
A:
[26-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
--
G
E
V
Y
E
G
Q
V
-----------
P
L
Q
-
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
------------------------------------
468
Blastp_CBE
66.74
38%
-135
- C4 -
-
3KF4
1
ABL1_MOUSE
B:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
---
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
--------------------------------------------------
553
Blastp_CBE
66.69
39%
-136
- C4 -
-
4AT5
2
A:
[9-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
----
K
----
I
L
-
V
A
V
K
T
L
K
D
-
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
F
Y
G
V
C
V
-
E
-
G
-
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
-
G
P
D
-----
A
V
L
M
A
--
E
G
N
P
P
T
--
E
-----
L
T
Q
S
Q
M
L
-------
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
N
-
E
-
V
I
-
E
C
I
T
Q
G
-------
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
----------------------------------------------------------------
507
Blastp_CBE
66.72
38%
-121
- C4 -
-
2HIW
1
ABL1_HUMAN
B:
[5-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
----------------------------------------------------
564
HHSearch
66.65
37%
-119
- C4 -
-
6BRJ
1
DDR1_HUMAN
A:
[568-872]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
------------
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
-
Q
-
D
-
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
-
Q
L
E
-----
D
--------------
P
T
----
I
S
Y
P
M
L
L
-------
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
-
Q
-
V
I
-
E
N
A
G
E
F
FRDQGRQ
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
------------------------------------------------------
265
Blastp_CBE
66.69
52%
-97
- C4 -
-
2X2L
5
A:
[1-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
S
L
S
V
D
A
F
K
I
L
---
P
-
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
--
K
G
R
A
G
Y
-
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
-
R
K
V
--------------------
R
A
----
L
T
M
G
D
L
I
-------
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
-
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
-----------------------------------------------------
523
Blastp_CBE
66.64
38%
-83
- C4 -
-
3L9P
4
A:
[67-357]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
--------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
--------------------------------------
405
Blastp_CBE
66.66
39%
-90
- C4 -
-
4ANQ
1
A:
[41-332]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
Q
V
-----------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
------------------------------------
503
Blastp_CBE
66.64
38%
-140
- C4 -
-
4YC8
3
ABL1_HUMAN
B:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
------
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------
490
Blastp_CBE
66.67
38%
-124
- C4 -
-
1IEP
1
ABL1_MOUSE
B:
[8-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-----------------------------------------------------
400
Blastp_CBE
66.66
38%
-90
- C4 -
-
5AA9
1
A:
[26-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
-----------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
------------------------------------
493
Blastp_CBE
66.65
38%
-122
- C4 -
-
1FPU
1
ABL1_MOUSE
A:
[8-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
----------------------------------------------------
221
Blastp_CBE
66.64
54%
-11
- C4 -
-
4AGD
1
A:
[52-350]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
-------
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------
550
Blastp_CBE
66.63
39%
-134
- C4 -
-
3CS9
1
ABL1_HUMAN
A:
[10-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
----
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
------------------------------------------------------
211
Blastp_CBE
66.59
54%
-26
- C4 -
-
3WZD
10
A:
[7-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
----
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
V
A
P
E
D
L
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
---------------------------------------------------
563
HHSearch
66.55
37%
-111
- C4 -
-
6BSD
1
DDR1_HUMAN
A:
[567-872]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---------
P
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
-
Q
-
D
-
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
-
Q
L
E
-----
D
K
A
---------
G
--
P
T
----
I
S
Y
P
M
L
L
-------
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
--
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
-
Q
-
V
I
-
E
N
A
G
E
F
FRDQGRQ
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
------------------------------------------------------
541
Blastp_CBE
66.54
39%
-129
- C4 -
-
2HYY
1
ABL1_HUMAN
A:
[8-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
-
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
------------------------------------------------------
530
Blastp_CBE
66.51
38%
-140
- C4 -
-
6NPU
2
ABL1_HUMAN
A:
[18-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
-------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
---------------------------------------------------
408
Blastp_CBE
66.48
38%
-89
- C4 -
-
5FTO
1
A:
[18-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
M
-------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
------------------------------------
539
Blastp_CBE
66.47
39%
-134
- C4 -
-
2HYY
1
ABL1_HUMAN
C:
[6-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
-
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
---
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
------------------------------------------------------
536
Blastp_CBE
66.39
39%
-139
- C4 -
-
2HZ4
1
ABL1_HUMAN
B:
[6-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
-----
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
------------------------------------------------------
456
Blastp_CBE
66.38
39%
-128
- C4 -
-
3QRJ
1
ABL1_HUMAN
B:
[11-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
------------------------------------------------------
532
Blastp_CBE
66.34
38%
-138
- C4 -
-
6NPE
2
ABL1_HUMAN
A:
[18-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
-------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
---------------------------------------------------
454
Blastp_CBE
66.33
38%
-88
- C4 -
-
5A9U
1
A:
[26-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
-----------
P
L
Q
-
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
------------------------------------
407
Blastp_CBE
66.31
38%
-89
- C4 -
-
5FTQ
2
A:
[18-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
-
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
------------------------------------
281
Blastp_CBE
66.31
48%
-9
- C4 -
-
3VHE
1
A:
[10-358]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
FVPYK---------------
D
L
YKDF
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------
517
Blastp_CBE
66.30
38%
-123
- C4 -
-
2G2I
1
ABL1_HUMAN
A:
[5-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
---
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------
418
Blastp_CBE
66.29
38%
-134
- C4 -
-
3IK3
1
ABL1_MOUSE
A:
[3-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
-------
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
306
Blastp_CBE
66.27
48%
-61
- C4 -
-
6ITT
2
?
B:
[20-325]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
Y
V
Y
I
D
P
T
Q
L
P
Y
D
-
H
-
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
-
I
K
S
D
A
A
--
M
T
-
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
----------------------------
M
E
D
D
E
L
A
LDLEDLL
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
-----------------------------------------------------
399
Blastp_CBE
66.26
38%
-86
- C4 -
-
5AAA
1
A:
[26-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
-----------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
--------------------------------------
403
Blastp_CBE
66.22
38%
-86
- C4 -
-
5AA8
1
A:
[26-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
-----------
P
L
Q
-
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
------------------------------------
551
Blastp_CBE
66.15
39%
-146
- C4 -
-
2HZI
1
ABL1_HUMAN
B:
[10-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
----
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
------------------------------------------------------
546
Blastp_CBE
66.13
39%
-120
- C4 -
-
2HZ0
1
ABL1_HUMAN
A:
[6-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
------------------------------------------------------
485
Blastp_CBE
66.07
38%
-122
- C4 -
-
2HZN
1
ABL1_MOUSE
A:
[8-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
---
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
--
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
--------------------------------------------------
441
Blastp_CBE
66.04
38%
-87
- C4 -
-
2YFX
1
A:
[26-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
Q
V
-----------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
--------------------------------------
264
Blastp_CBE
66.06
52%
-104
- C4 -
-
2X2M
4
RET_HUMAN
A:
[1-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
S
L
S
V
D
A
F
K
I
L
-
D
-
P
-
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
--
G
E
F
G
K
V
V
K
A
T
A
F
H
L
--
K
G
R
A
G
Y
-
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
------------------------
R
A
----
L
T
M
G
D
L
I
-------
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
-
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
-----------------------------------------------------
423
Blastp_CBE
66.04
38%
-90
- C4 -
-
4CTB
1
A:
[26-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
---
F
G
E
V
Y
E
G
Q
V
-----------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
------------------------------------
469
Blastp_CBE
66.03
38%
-133
- C4 -
-
3KF4
1
ABL1_MOUSE
A:
[3-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
-------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
318
Blastp_CBE
66.02
45%
-110
- C4 -
-
6MWE
1
TIE2_HUMAN
A:
[23-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
N
F
G
Q
V
L
K
A
R
---
I
-
K
K
D
--
G
L
R
M
D
-
A
A
I
K
R
M
-------------
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
-
H
-
R
-
G
Y
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
-
R
V
L
-----
E
T
D
P
A
F
A
I
A
N
S
T
A
--
S
T
----
L
S
S
Q
Q
L
L
-------
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
---
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
---
G
Q
E
V
Y
--
K
T
M
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
-
G
G
T
P
Y
C
G
M
T
C
A
-
E
-
L
Y
-
E
K
L
P
Q
G
-------
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
--
Y
V
N
-
T
T
L
Y
E
K
F
T
Y
A
G
I
D
C
S
A
E
E
-------------------------
492
Blastp_CBE
66.01
38%
-121
- C4 -
-
1FPU
1
ABL1_MOUSE
B:
[8-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
------
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
----------------------------------------------------
431
Blastp_CBE
65.99
38%
-90
- C4 -
-
4CCB
1
A:
[26-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
-----------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
---P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
--------------------------------------
472
Blastp_CBE
65.96
38%
-84
- C4 -
-
4Z55
3
A:
[39-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
----------
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
-
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
---------------------------------------
494
Blastp_CBE
65.95
38%
-85
- C4 -
-
3AOX
5
A:
[43-334]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
E
G
Q
V
----------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
------------------------------------
479
Blastp_CBE
65.88
38%
-135
- C4 -
-
3MSS
2
ABL1_MOUSE
B:
[5-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
--------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-----------------------------------------------------
453
Blastp_CBE
65.86
38%
-88
- C4 -
-
5AAC
1
A:
[26-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
-----------
P
L
Q
-
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
------------------------------------
457
Blastp_CBE
65.85
39%
-143
- C4 -
-
3QRJ
1
ABL1_HUMAN
A:
[12-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
-----
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
-------------------------------------------------------
392
Blastp_CBE
65.83
41%
-140
- C4 -
-
4XLI
1
B:
[2-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
----
G
E
V
Y
----
V
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
--------------------
E
C
S
R
--
E
E
----
V
T
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
D
L
L
E
K
G
-------
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
---------------------------------------------------------------
571
HHSearch
65.82
40%
-130
- C4 -
-
3BKB
7
A:
[108-374]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
L
N
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
--------
N
T
L
-
V
A
V
K
S
C
R
E
T
L
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
-
K
-
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
-
G
----------------------
A
R
----
L
R
V
K
T
L
L
-------
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
-
G
A
S
P
Y
P
N
L
S
N
Q
-
Q
-
T
R
-
E
F
V
E
K
G
-------
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
-----------------------------------------------------
502
Blastp_CBE
65.80
38%
-131
- C4 -
-
4XEY
1
ABL1_HUMAN
A:
[116-388]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
----
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
------------------------------------------------
528
Blastp_CBE
65.69
38%
-137
- C4 -
-
6NPV
2
ABL1_HUMAN
A:
[18-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
-------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
---------------------------------------------------
406
Blastp_CBE
65.70
38%
-92
- C4 -
-
6MX8
1
A:
[17-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
----------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
--P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
-------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
--------------------------------------
513
Blastp_CBE
65.69
38%
-91
- C4 -
-
4FOC
1
A:
[53-345]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
---------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
G
-----------------------------------
463
Blastp_CBE
65.67
38%
-131
- C4 -
-
4WA9
1
ABL1_HUMAN
B:
[7-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
271
Blastp_CBE
65.66
52%
-98
- C4 -
-
2IVV
3
A:
[1-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
S
L
S
V
D
A
F
K
I
------
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
--
K
G
R
A
G
Y
-
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
-
R
----------------------------
L
T
M
G
D
L
I
-------
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
S
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
-
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
-----------------------------------------------------
478
Blastp_CBE
65.60
38%
-135
- C4 -
-
3MSS
2
ABL1_MOUSE
C:
[5-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
--------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-----------------------------------------------------
263
Blastp_CBE
65.58
52%
-106
- C4 -
-
2X2M
5
B:
[1-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
S
L
S
V
D
A
F
K
I
----
P
-
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
----
K
V
V
K
A
T
A
F
H
L
--
K
G
R
A
G
Y
-
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
-------------------------
A
----
L
T
M
G
D
L
I
-------
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
-
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
-----------------------------------------------------
223
Blastp_CBE
65.57
54%
-17
- C4 -
-
3EWH
2
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
---
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
V
A
P
E
D
L
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
----
D
P
D
Y
V
-----
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------
316
Blastp_CBE
65.55
46%
-62
- C4 -
-
5GRN
1
A:
[39-337]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
R
W
E
F
P
R
D
G
L
V
L
G
R
V
L
G
S
G
A
F
G
K
V
V
E
G
T
A
Y
G
L
-
S
--
R
S
Q
P
V
M
K
-
V
A
V
K
M
L
K
P
T
A
R
S
S
E
K
Q
A
L
M
S
E
L
K
I
M
T
H
L
G
P
H
L
N
I
V
N
L
L
G
A
C
T
-
K
-
S
-
G
P
I
Y
I
I
T
E
Y
C
F
Y
G
D
L
V
N
Y
L
H
K
N
-
R
D
S
-----
F
L
S
----------NS
E
G
----
L
T
L
L
D
L
L
-------
S
F
T
Y
Q
V
A
R
G
M
E
F
L
A
S
K
N
C
V
H
R
D
L
A
A
R
N
V
L
L
A
---
Q
G
K
I
V
K
I
C
D
F
G
L
A
R
D
I
M
H
D
S
N
Y
V
S
K
G
S
T
F
L
P
V
K
W
M
A
P
E
S
I
F
D
N
L
Y
T
T
L
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
G
T
P
Y
P
G
M
M
V
D
-
S
-
T
F
Y
N
K
I
K
S
G
-------
Y
R
M
A
K
P
D
H
A
T
S
E
V
Y
E
I
M
V
K
C
W
N
S
E
P
E
K
R
P
S
F
Y
H
L
S
E
I
V
E
N
L
L
------------------------------------------------------
245
Blastp_CBE
65.54
54%
-20
- C4 -
-
3B8R
2
VGFR2_HUMAN
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
-----
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
V
A
P
E
D
L
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
-----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------
477
Blastp_CBE
65.49
38%
-136
- C4 -
-
3MSS
2
ABL1_MOUSE
D:
[5-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
--------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-----------------------------------------------------
270
Blastp_CBE
65.47
53%
-69
- C4 -
-
6FEK
4
A:
[1-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
S
L
S
V
D
A
F
K
I
L
A
A
-
P
-
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
--
K
G
R
A
G
Y
-
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
-
R
K
V
-----
G
-------
P
G
P
D
E
--
R
A
----
L
T
M
G
D
L
I
-------
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
E
E
-
D
F
V
K
R
S
-
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
-----------------------------------------------------
248
Blastp_CBE
65.47
54%
-15
- C4 -
-
2RL5
1
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
V
A
P
E
D
L
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
--------------
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------
526
Blastp_CBE
65.46
39%
-129
- C4 -
-
5HU9
13
ABL1_HUMAN
A:
[7-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
---------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
------------------------------------------------------
396
Blastp_CBE
65.44
41%
-134
- C4 -
-
2XYN
4
ABL2_HUMAN
C:
[27-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
----
V
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
--
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
E
E
----
V
T
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
D
L
L
E
K
G
-------
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
---------------------------------------------------------------
362
Blastp_CBE
65.41
40%
-117
- C4 -
-
3EKN
1
A:
[12-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
G
E
A
E
--
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
S
-
K
-
G
-
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
-
R
P
E
-----
A
E
N
---
N
P
G
R
P
P
P
---------
T
L
Q
E
M
I
-------
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
K
F
V
M
D
G
-------
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
----------------------------------------------------------
520
Blastp_CBE
65.23
38%
-127
- C4 -
-
2G2F
1
ABL1_HUMAN
B:
[9-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
-----
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------
284
Blastp_CBE
65.23
48%
-10
- C4 -
-
3VHK
2
A:
[17-365]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
FVPYK-----------------YKDF
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------
393
Blastp_CBE
65.20
41%
-141
- C4 -
-
4XLI
1
ABL2_MOUSE
A:
[2-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
----
V
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
----
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
--------------------
E
C
S
R
--
E
E
----
V
T
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
D
L
L
E
K
G
-------
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
---------------------------------------------------------------
311
Blastp_CBE
65.20
50%
-53
- C4 -
-
1PKG
1
KIT_HUMAN
A:
[27-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
-
H
-
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
-
I
K
S
D
A
A
--
M
T
-
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
D
----------
S
F
I
C
S
K
-----------------
A
LDLEDLL
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
-------------------------------------------------------
398
Blastp_CBE
65.19
41%
-137
- C4 -
-
2XYN
2
ABL2_HUMAN
A:
[26-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
----
V
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
--
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
E
E
----
V
T
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
D
L
L
E
K
G
-------
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
---------------------------------------------------------------
410
Blastp_CBE
65.17
38%
-85
- C4 -
-
2XB7
1
A:
[18-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
--------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
------------------------------------
251
Blastp_CBE
65.15
54%
-17
- C4 -
-
2QU5
1
A:
[6-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
V
A
P
E
D
L
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
-------------
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
------------------------------------------------
462
Blastp_CBE
65.12
39%
-141
- C4 -
-
4TWP
1
ABL1_HUMAN
A:
[2-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
-----
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
--------------------------------------------------
230
Blastp_CBE
65.11
55%
-27
- C4 -
-
2P2I
1
VGFR2_HUMAN
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
---
T
C
R
--
T
-
V
A
V
K
M
L
----
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
V
A
P
E
D
L
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------
514
Blastp_CBE
65.08
38%
-89
- C4 -
-
4FOB
1
A:
[53-345]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
---------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
---P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
G
-----------------------------------
216
Blastp_CBE
65.02
54%
-25
- C4 -
-
5EW3
1
VGFR2_HUMAN
A:
[16-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
V
------
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------
243
Blastp_CBE
65.00
54%
-17
- C4 -
-
3BE2
1
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
---
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
V
A
P
E
D
L
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------
504
Blastp_CBE
64.91
38%
-144
- C4 -
-
4YC8
3
ABL1_HUMAN
A:
[8-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
------
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
----
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
--------------------------------------------------
397
Blastp_CBE
64.89
41%
-135
- C4 -
-
2XYN
4
ABL2_HUMAN
B:
[26-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
----
V
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
--
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
E
E
----
V
T
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
D
L
L
E
K
G
-------
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
---------------------------------------------------------------
480
Blastp_CBE
64.86
38%
-134
- C4 -
-
3MSS
2
ABL1_MOUSE
A:
[5-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
--------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-----------------------------------------------------
427
Blastp_CBE
64.83
38%
-89
- C4 -
-
4CMT
1
A:
[26-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
-----------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
---P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
--------------------------------------
394
Blastp_CBE
64.83
41%
-134
- C4 -
-
3HMI
1
ABL2_HUMAN
A:
[26-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
----
V
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
E
E
----
V
T
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
D
L
L
E
K
G
-------
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
---------------------------------------------------------------
498
Blastp_CBE
64.78
38%
-127
- C4 -
-
2E2B
1
ABL1_HUMAN
A:
[8-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
----
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
----
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-------------------------------------------------
366
Blastp_CBE
64.80
40%
-123
- C4 -
-
1I44
1
A:
[11-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
G
E
A
E
--
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
S
-
K
-
G
-
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
-
R
P
E
-----
A
E
N
---
N
P
G
R
P
P
P
---------
T
L
Q
E
M
I
-------
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
----------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
K
F
V
M
D
G
-------
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
----------------------------------------------------------
252
Blastp_CBE
64.78
54%
-18
- C4 -
-
2P2H
1
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
----
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
V
A
P
E
D
L
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
---------------
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------
228
Blastp_CBE
64.70
55%
-20
- C4 -
-
3EFL
1
VGFR2_HUMAN
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
-
D
---
T
C
R
--
T
-
V
A
V
K
M
L
K
E
--
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
V
A
P
E
D
L
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------
412
Blastp_CBE
64.64
38%
-94
- C4 -
-
6EDL
1
A:
[26-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
V
S
---------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
----------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
---------------------------------------
482
Blastp_CBE
64.57
38%
-130
- C4 -
-
3MS9
2
ABL1_MOUSE
A:
[8-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
--------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
--
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-----------------------------------------------------
422
Blastp_CBE
64.58
38%
-87
- C4 -
-
4CTC
1
A:
[26-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
E
G
Q
V
-----------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
------------------------------------
246
Blastp_CBE
64.57
54%
-21
- C4 -
-
3B8Q
1
B:
[6-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
------
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
----------------------------------------------------
432
Blastp_CBE
64.55
38%
-90
- C4 -
-
2XP2
1
A:
[26-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
Q
V
-----------
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
---P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
--------------------------------------
242
Blastp_CBE
64.51
54%
-14
- C4 -
-
3CP9
1
VGFR2_HUMAN
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
------
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
V
A
P
E
D
L
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------
421
Blastp_CBE
64.48
38%
-91
- C4 -
-
5IMX
1
A:
[26-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
----------
S
P
L
Q
-
V
A
V
K
T
L
---------
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
----------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
--------------------------------------
317
Blastp_CBE
64.45
45%
-104
- C4 -
-
6MWE
1
B:
[23-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
N
F
G
Q
V
L
K
A
R
---
I
-
K
K
D
--
G
L
R
M
D
-
A
A
I
K
R
--------------
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
-
H
-
R
-
G
Y
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
-
R
V
L
-----
E
T
D
P
A
F
A
I
A
N
S
T
A
--
S
T
----
L
S
S
Q
Q
L
L
-------
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
---
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
---
G
Q
E
V
---
K
T
M
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
-
G
G
T
P
Y
C
G
M
T
C
A
-
E
-
L
Y
-
E
K
L
P
Q
G
-------
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
--
Y
V
N
-
T
T
L
Y
E
K
F
T
Y
A
G
I
D
C
S
A
E
E
-------------------------
413
Blastp_CBE
64.42
38%
-90
- C4 -
-
6EBW
1
A:
[26-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
--
F
G
E
V
Y
E
G
Q
V
S
---------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
--P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
--------------
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
---------------------------------------
244
Blastp_CBE
64.42
54%
-26
- C4 -
-
3B8R
1
B:
[7-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
---
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
------
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
-----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
----------------------------------------------------
548
Blastp_CBE
64.40
39%
-148
- C4 -
-
3CS9
1
ABL1_HUMAN
C:
[9-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
-----
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
-------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
------------------------------------------------------
414
Blastp_CBE
64.33
38%
-93
- C4 -
-
6E0R
1
A:
[26-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
----
V
Y
E
G
Q
V
----------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
-----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
---------------------------------------
259
Blastp_CBE
64.33
53%
-76
- C4 -
-
5AMN
8
A:
[1-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
S
L
S
V
D
A
F
K
I
--
D
-
P
-
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
--
K
G
R
A
G
Y
-
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
-
R
K
V
-----------------
E
--
R
A
----
L
T
M
G
D
L
I
-------
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
E
E
-
D
S
V
K
R
S
-
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
-----------------------------------------------------
319
Blastp_CBE
64.30
45%
-112
- C4 -
-
3L8P
1
A:
[23-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
N
F
G
Q
V
L
K
A
R
---
I
-
K
K
D
--
G
L
R
M
D
-
A
A
I
K
R
M
-----------
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
-
H
-
R
-
G
Y
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
-
R
V
L
-----
E
T
D
P
A
F
A
I
A
N
S
T
A
--
S
T
----
L
S
S
Q
Q
L
L
-------
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
---
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
---
G
Q
E
V
Y
V
K
K
-----
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
-
G
G
T
P
Y
C
G
M
T
C
A
-
E
-
L
Y
-
E
K
L
P
Q
G
-------
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
--
Y
V
N
-
T
T
L
Y
E
K
F
T
Y
A
G
I
D
C
S
A
E
--------------------------
465
Blastp_CBE
64.29
38%
-138
- C4 -
-
3OXZ
1
ABL1_MOUSE
A:
[3-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
--------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
Q
E
----
V
S
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
-----------
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
247
Blastp_CBE
64.23
54%
-16
- C4 -
-
3B8Q
1
VGFR2_HUMAN
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
V
A
P
E
D
L
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------
323
Blastp_CBE
64.20
45%
-122
- C4 -
-
2OO8
1
X:
[29-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
V
L
K
A
R
---
I
--------
R
M
D
-
A
A
I
K
R
M
K
E
---
K
D
D
H
R
D
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
-
H
------
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
-
R
V
L
-----
E
T
D
P
A
F
A
I
A
N
S
T
A
--
S
T
----
L
S
S
Q
Q
L
L
-------
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
---
E
N
Y
V
A
K
I
A
D
F
G
L
--------------
M
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
-
G
G
T
P
Y
C
G
M
T
C
A
-
E
-
L
Y
-
E
K
L
P
Q
G
-------
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
--
Y
V
N
-
T
T
L
Y
E
K
F
T
Y
A
G
I
D
------------------------------
395
Blastp_CBE
64.19
41%
-133
- C4 -
-
3GVU
2
ABL2_HUMAN
A:
[26-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
----
V
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
L
-
E
-
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
--
R
--
E
E
----
V
T
A
V
V
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
----
G
D
T
Y
T
----
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
D
L
L
E
K
G
-------
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
---------------------------------------------------------------
543
Blastp_CBE
64.18
39%
-137
- C4 -
-
3QRI
1
ABL1_HUMAN
B:
[10-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
-----
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
------------------------------------------------------
310
Blastp_CBE
64.12
50%
-65
- C4 -
-
1PKG
1
B:
[27-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
P
Y
D
-
H
-
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
-
I
K
S
D
A
A
--
M
T
-
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
-
I
-
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
D
----------
S
F
I
C
--------------------LDLEDLL
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
-------------
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
-
F
Y
-
K
M
I
K
E
G
-------
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
-----------------------------------------------------
516
Blastp_CBE
64.11
38%
-128
- C4 -
-
2G2I
1
ABL1_HUMAN
B:
[7-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
----
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
---------------------------------------------------
425
Blastp_CBE
64.10
38%
-88
- C4 -
-
4CNH
1
ALK_HUMAN
A:
[26-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
------
E
V
Y
E
G
Q
V
----------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
------------------------------------
529
Blastp_CBE
64.04
38%
-147
- C4 -
-
6NPU
5
ABL1_HUMAN
B:
[19-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
--------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
----------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
549
Blastp_CBE
63.80
39%
-149
- C4 -
-
3CS9
1
ABL1_HUMAN
B:
[10-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
---
T
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
-------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
------------------------------------------------------
229
Blastp_CBE
63.80
55%
-25
- C4 -
-
2P2I
1
B:
[6-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
----
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
-----------
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
--------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------
371
Blastp_CBE
63.61
39%
-142
- C4 -
-
4CSV
1
?
A:
[5-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
N
Y
-
N
-------
I
E
-
V
A
V
K
T
L
K
E
G
T
M
S
--
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
L
Y
G
V
C
T
-
K
-
E
-
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
------------------
D
C
------------
V
N
A
Q
A
L
L
-------
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
N
V
V
K
V
A
D
F
G
------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
-
G
Q
V
P
Y
P
G
M
S
G
S
-
E
-
V
I
-
E
Q
V
E
R
G
-------
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
------------------------------------------------------
409
Blastp_CBE
63.56
38%
-92
- C4 -
-
2XBA
1
A:
[18-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
-------
V
Y
E
G
Q
V
----------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
P
S
Q
P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
----------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
-
Y
------------------------------------
294
Blastp_CBE
63.52
49%
-80
- C4 -
-
6JQR
5
?
A:
[26-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
E
Y
D
-
L
-
K
W
E
F
P
R
E
N
L
E
F
G
K
V
L
G
S
G
A
F
G
K
V
M
N
A
T
A
Y
G
I
-
S
-----
V
S
I
Q
-
V
A
V
K
M
L
K
E
--
D
S
S
E
R
E
A
L
M
S
E
L
K
M
M
T
Q
L
G
S
H
E
N
I
V
N
L
L
G
A
C
T
-
L
-
S
-
G
P
I
Y
L
I
F
E
Y
C
C
Y
G
D
L
L
N
Y
L
R
S
K
-
R
E
K
-----
F
S
---------------NV--
L
T
F
E
D
L
L
-------
C
F
A
Y
Q
V
A
K
G
M
E
F
L
E
F
K
S
C
V
H
R
D
L
A
A
R
N
V
L
V
T
---
H
G
K
V
V
K
I
C
D
F
------
M
S
D
S
N
Y
V
V
R
G
N
A
R
L
P
V
K
W
M
A
P
E
S
L
F
E
G
I
Y
T
I
K
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
V
N
P
Y
P
G
I
P
V
D
A
N
-
F
Y
-
K
L
I
Q
N
G
-------
F
K
M
D
Q
P
F
Y
A
T
E
E
I
Y
I
I
M
Q
S
C
W
A
F
D
S
R
K
R
P
S
F
P
N
L
T
S
F
L
----------------------------------------------------------
275
Blastp_CBE
63.44
52%
-65
- C4 -
-
4CKI
9
A:
[1-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
S
L
S
V
D
A
F
K
I
L
E
D
-
P
-
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
--
K
G
R
A
G
Y
-
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
-
R
K
V
----------------
D
E
--
R
A
----
L
T
M
G
D
L
I
-------
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
E
E
-
D
S
V
K
R
S
-
Q
G
R
I
P
V
K
W
T
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
-----------------------------------------------------
324
Blastp_CBE
63.31
44%
-111
- C4 -
-
2WQB
1
A:
[30-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
--
G
Q
V
L
K
A
R
---
I
-
K
K
D
--
G
L
R
M
D
-
A
A
I
K
R
M
K
-------------
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
-
H
-
R
-
G
Y
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
-
R
V
L
-----
E
T
D
P
A
F
A
I
A
N
S
T
A
--
S
T
----
L
S
S
Q
Q
L
L
-------
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
N
L
A
A
R
N
I
L
V
G
---
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
---
G
Q
E
V
Y
V
K
K
T
-
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
-
G
G
T
P
Y
C
G
M
T
C
A
-
E
-
L
Y
-
E
K
L
P
Q
G
-------
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
--
Y
V
N
-
T
T
L
Y
E
K
F
T
Y
A
G
I
D
C
S
A
---------------------------
240
Blastp_CBE
63.29
54%
-18
- C4 -
-
3CPB
1
VGFR2_HUMAN
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
------
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
V
A
P
E
D
L
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------
370
Blastp_CBE
63.28
39%
-132
- C4 -
-
4UEU
1
?
A:
[5-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
N
Y
-
N
-------
I
E
-
V
A
V
K
T
L
K
E
G
T
M
S
--
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
L
Y
G
V
C
T
-
K
-
E
-
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
------------------
D
C
E
G
----
H
T
----
V
N
A
Q
A
L
L
-------
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
-----------
A
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
-
G
Q
V
P
Y
P
G
M
S
G
S
-
E
-
V
I
-
E
Q
V
E
R
G
-------
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
------------------------------------------------------
527
Blastp_CBE
63.19
38%
-143
- C4 -
-
6NPV
5
ABL1_HUMAN
B:
[19-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
--------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
----------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
442
Blastp_CBE
63.23
38%
-80
- C4 -
-
4TT7
5
A:
[17-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
E
G
Q
V
----------
S
P
L
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
-
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
P
---------------
R
---P-
S
S
----
L
A
M
L
D
L
L
-------
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
S
--
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
-
E
-
V
L
-
E
F
V
T
S
G
-------
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
---
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
--------------------------------------
215
Blastp_CBE
63.19
54%
-26
- C4 -
-
5EW3
1
B:
[15-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
----
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
--------
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
-----------------------------------------------------
273
Blastp_CBE
63.11
52%
-70
- C4 -
-
6NE7
3
A:
[1-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
S
L
S
V
D
A
F
K
I
L
E
D
-
P
-
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
--
K
G
R
A
G
Y
-
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-
G
P
L
L
L
I
V
E
Y
A
K
Y
A
S
L
R
G
F
L
R
E
S
-
R
K
V
-----
G
-----------
E
--
R
A
----
L
T
M
G
D
L
I
-------
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
E
E
-
D
S
V
K
R
S
-
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
-----------------------------------------------------
272
Blastp_CBE
63.06
52%
-69
- C4 -
-
6NJA
3
A:
[1-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
S
L
S
V
D
A
F
K
I
L
E
D
-
P
-
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
--
K
G
R
A
G
Y
-
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
-
R
K
V
-----------------
E
--
R
A
----
L
T
M
G
D
L
I
-------
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
E
E
-
D
S
V
K
R
S
-
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
-----------------------------------------------------
236
Blastp_CBE
63.04
54%
-13
- C4 -
-
3DTW
1
VGFR2_HUMAN
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
--
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
V
A
P
E
D
L
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------
227
Blastp_CBE
63.03
55%
-31
- C4 -
-
3EFL
1
B:
[7-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
---
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
-----------
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
-----------------------------------------------------
533
Blastp_CBE
63.02
38%
-143
- C4 -
-
3PYY
3
ABL1_HUMAN
B:
[19-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
--------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
----------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
286
Blastp_CBE
63.00
47%
-16
- C4 -
-
3HNG
1
A:
[14-360]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
A
S
-
K
W
E
F
A
R
E
R
L
K
L
G
K
S
L
G
R
G
A
F
G
K
V
V
Q
A
S
A
F
G
I
-
K
K
S
P
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
A
S
E
Y
K
A
L
M
T
E
L
K
I
L
T
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
Q
-
G
-
G
P
L
M
V
I
V
E
Y
C
K
Y
G
N
L
S
N
Y
L
K
S
K
-
R
--------------------K-
E
P
----
I
T
M
E
D
L
I
-------
S
Y
S
F
Q
V
A
R
G
M
E
F
L
S
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
N
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
N
P
D
Y
V
R
K
--
T
R
L
P
L
K
W
M
A
P
E
S
I
F
D
K
I
Y
S
T
K
S
D
V
W
S
Y
G
V
L
L
W
E
I
F
S
L
-
G
G
S
P
Y
P
G
V
Q
M
D
-
E
-
D
F
C
S
R
L
R
E
G
-------
M
R
M
R
A
P
E
Y
S
T
P
E
I
Y
Q
I
M
L
D
C
W
H
R
D
P
K
E
R
P
R
F
A
E
L
V
E
K
L
G
D
L
L
------------------------------------------------------
497
Blastp_CBE
62.96
38%
-130
- C4 -
-
2E2B
1
ABL1_HUMAN
B:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
-----
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
-------
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
------------------------------------------------------
337
Blastp_CBE
62.96
40%
-50
- C4 -
-
3LW0
2
IGF1R_HUMAN
A:
[9-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
D
---
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
-
Q
-
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
-
R
P
----------------
P
P
----------
S
L
S
K
M
I
-------
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
R
F
V
M
E
G
-------
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
----------------------------------------------------------
335
Blastp_CBE
62.87
40%
-51
- C4 -
-
3LW0
3
IGF1R_HUMAN
C:
[9-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
D
---
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
-
Q
-
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
-
R
P
----------------
P
P
----------
S
L
S
K
M
I
-------
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
R
F
V
M
E
G
-------
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
----------------------------------------------------------
344
Blastp_CBE
62.84
40%
-38
- C4 -
-
3NW6
1
A:
[7-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
V
P
-
D
-
E
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
D
---
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
-
Q
-
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
-
R
P
E
-----
M
E
N
N
P
--
V
L
A
P
P
----------
S
L
S
K
M
I
-------
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
R
F
V
M
E
G
-------
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
----------------------------------------------------------
241
Blastp_CBE
62.83
54%
-26
- C4 -
-
3CP9
1
B:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
---
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
V
------
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
-----------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
-----------------------------------------------------
336
Blastp_CBE
62.80
40%
-50
- C4 -
-
3LW0
3
IGF1R_HUMAN
B:
[9-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
D
---
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
-
Q
-
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
-
R
P
----------------
P
P
----------
S
L
S
K
M
I
-------
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
R
F
V
M
E
G
-------
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
----------------------------------------------------------
531
Blastp_CBE
62.81
38%
-147
- C4 -
-
6NPE
3
ABL1_HUMAN
B:
[19-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
--------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
235
Blastp_CBE
62.80
54%
-24
- C4 -
-
3DTW
1
B:
[6-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
---
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
------
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
----------------
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
----------------------------------------------------
238
Blastp_CBE
62.77
54%
-20
- C4 -
-
3CPC
1
VGFR2_HUMAN
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
------
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
V
A
P
E
D
L
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------
249
Blastp_CBE
62.60
54%
-19
- C4 -
-
2QU6
1
B:
[8-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
----
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
-------------
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
-------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
-----------------------------------------------------
334
Blastp_CBE
62.56
40%
-49
- C4 -
-
3LW0
2
D:
[9-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
D
---
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
-
Q
-
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
-
R
P
----------------
P
P
----------
S
L
S
K
M
I
-------
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
R
F
V
M
E
G
-------
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
----------------------------------------------------------
282
Blastp_CBE
62.53
48%
-34
- C4 -
-
1Y6B
1
A:
[15-363]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
--
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
FVPY------------------F---
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
--------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------
280
Blastp_CBE
62.46
48%
2
- C4 -
-
3VID
1
A:
[8-356]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
FVPYK---------
E
A
P
E
--
D
L
YKDF
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
-------
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------
320
Blastp_CBE
62.30
45%
-122
- C4 -
-
2P4I
1
B:
[29-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
V
L
K
A
R
---
I
--------
R
M
D
-
A
A
I
K
R
M
K
E
---
K
D
D
H
R
D
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
-
H
------
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
-
R
V
L
-----
E
T
D
P
A
F
A
I
A
N
S
T
A
--
S
T
----
L
S
S
Q
Q
L
L
-------
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
---
E
N
Y
V
A
K
I
A
D
F
G
L
---------------
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
-
G
G
T
P
Y
C
G
M
T
C
A
-
E
-
L
Y
-
E
K
L
P
Q
G
-------
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
--
Y
V
N
-
T
T
L
Y
E
K
F
T
Y
A
G
I
D
------------------------------
322
Blastp_CBE
62.28
45%
-124
- C4 -
-
2OSC
1
A:
[30-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
L
K
A
R
---
I
---------
M
D
-
A
A
I
K
R
M
K
----
K
D
D
H
R
D
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
-
H
------
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
-
R
V
L
-----
E
T
D
P
A
F
A
I
A
N
S
T
A
--
S
T
----
L
S
S
Q
Q
L
L
-------
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
---
E
N
Y
V
A
K
I
A
D
F
G
L
--------------
M
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
-
G
G
T
P
Y
C
G
M
T
C
A
-
E
-
L
Y
-
E
K
L
P
Q
G
-------
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
--
Y
V
N
-
T
T
L
Y
E
K
F
T
Y
A
G
I
-------------------------------
250
Blastp_CBE
62.24
54%
-18
- C4 -
-
2QU6
1
VGFR2_HUMAN
A:
[6-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
-----
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
--
T
C
R
--
T
-
V
A
V
K
M
L
K
---
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
V
A
P
E
D
L
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
-------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------
237
Blastp_CBE
62.07
54%
-26
- C4 -
-
3CPC
1
B:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
-----
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
---
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
--------
Y
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
-----------------------------------------------------
239
Blastp_CBE
61.83
54%
-27
- C4 -
-
3CPB
1
B:
[6-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
-----
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
---
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
-------
K
--
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
------------------
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
-----------------------------------------------------
351
Blastp_CBE
61.81
40%
-47
- C4 -
-
3I81
1
A:
[12-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
D
---
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
S
-
Q
-
G
-
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
-
R
P
E
------
E
N
N
P
--
V
L
A
P
P
----------
S
L
S
K
M
I
-------
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
-----
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
R
F
V
M
E
G
-------
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
----------------------------------------------------------
545
Blastp_CBE
61.36
39%
-141
- C4 -
-
2HZ0
1
ABL1_HUMAN
B:
[3-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
-
D
-
K
W
E
M
E
R
T
D
I
T
M
K
H
K
L
------
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
K
T
L
----
M
E
--
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
------------------------------------------------------
464
Blastp_CBE
61.09
38%
-130
- C4 -
-
4WA9
1
ABL1_HUMAN
A:
[10-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
----
G
V
-
W
K
K
Y
S
---
L
T
-
V
A
V
----------------------
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
---
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
------------------
C
N
R
Q
E
--
V
N
----
A
V
V
--
L
L
-------
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
-
Q
-
V
Y
-
E
L
L
E
K
D
-------
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------------------------------------
283
Blastp_CBE
60.73
48%
-22
- C4 -
-
1Y6A
1
A:
[15-362]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
----
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
----
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
FVPY------------------DF--
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
--------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
---------------------------------------------------
555
Blastp_CBE
60.66
39%
-69
- C4 -
-
4AT3
1
A:
[9-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
C---
K
----
I
L
-
V
A
V
K
T
L
---
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
F
Y
G
V
C
V
-
E
-
G
-
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
-
G
P
D
-----
A
V
L
M
A
----
N
P
P
T
--
E
-----
L
T
Q
S
Q
M
L
-------
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
L
L
V
K
I
G
D
F
G
M
S
R
--
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
N
-
E
-
V
I
-
E
C
I
T
Q
G
-------
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
----------------------------------------------------------------
321
Blastp_CBE
60.45
45%
-122
- C4 -
-
2P4I
1
TIE2_HUMAN
A:
[31-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
A
R
---
I
--------
R
M
D
-
A
A
I
K
R
--------------
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
-
H
------
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
-
R
V
L
-----
E
T
D
P
A
F
A
I
A
N
S
T
A
--
S
T
----
L
S
S
Q
Q
L
L
-------
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
---
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
--------
V
K
K
T
M
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
-
G
G
T
P
Y
C
G
M
T
C
A
-
E
-
L
Y
-
E
K
L
P
Q
G
-------
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
--
Y
V
N
-
T
T
L
Y
E
K
F
T
Y
A
G
I
D
------------------------------
234
Blastp_CBE
60.37
55%
-10
- C4 -
-
2OH4
1
A:
[16-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
N
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
-------------YKDF
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
K
D
P
D
V
R
K
--
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------
554
Blastp_CBE
60.30
39%
-62
- C4 -
-
4AT4
1
A:
[9-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
C---
K
----
I
L
-
V
A
V
K
T
L
K
D
-
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
F
Y
G
V
C
V
-
E
-
G
-
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
-
G
P
D
-----
A
V
L
M
A
-----
P
P
T
--
E
-----
L
T
Q
S
Q
M
L
-------
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
N
-
E
-
V
I
-
E
C
I
T
Q
G
-------
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
----------------------------------------------------------------
233
Blastp_CBE
59.84
55%
-26
- C4 -
-
1YWN
1
A:
[15-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
C
R
--
T
-
V
A
V
K
M
L
----
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
-------------
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
-----
I
K
D
P
D
V
R
K
--
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------
325
Blastp_CBE
59.51
45%
-131
- C4 -
-
4X3J
1
A:
[37-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
A
-------------
R
M
D
-
A
A
I
K
----------------
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
-----------
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
-
R
V
L
-----
E
T
D
P
A
F
A
I
A
N
S
T
A
--
S
T
----
L
S
S
Q
Q
L
L
-------
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
N
L
A
A
R
N
I
L
V
G
---
E
N
Y
V
A
K
I
A
D
F
G
------------------
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
-
G
G
T
P
Y
C
G
M
T
C
A
-
E
-
L
Y
-
E
K
L
P
Q
G
-------
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
--
Y
V
N
-
T
T
L
Y
E
K
F
T
Y
A
G
I
D
------------------------------
278
Blastp_CBE
56.40
52%
-64
- C4 -
-
5FM3
1
A:
[49-352]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
F
K
I
L
E
D
-
P
-
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
--
K
G
R
A
G
Y
-
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-
G
P
L
L
L
I
V
E
Y
A
-
K
G
S
L
R
G
F
L
R
E
S
-
R
----------------------------
L
T
M
G
D
L
I
-------
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
--
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
T
T
-
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
-----------------------------------------------------
279
Blastp_CBE
56.18
52%
-65
- C4 -
-
5FM2
1
A:
[52-352]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
L
E
D
-
P
-
K
W
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
--
K
G
R
A
G
Y
-
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
-
D
-
G
P
L
L
L
I
V
E
Y
A
-
K
G
S
L
R
G
F
L
R
E
S
-
R
----------------------------
L
T
M
G
D
L
I
-------
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
--
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
T
T
-
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
-
R
-
L
F
-
N
L
L
K
T
G
-------
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
-----------------------------------------------------
499
Blastp_CBE
55.35
40%
-54
- C4 -
-
1IR3
1
A:
[11-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
G
E
A
E
--
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
S
-
K
-
G
-
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
-
R
P
E
-----
A
E
N
---
N
P
G
R
P
P
P
---------
T
L
Q
E
M
I
-------
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
K
F
V
M
D
G
-------
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
----------------------------------------------------------
455
Blastp_CBE
55.04
40%
-54
- C4 -
-
2Z8C
1
A:
[8-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
G
E
A
E
--
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
S
-
K
-
G
-
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
-
R
P
E
-----
A
E
N
---
N
P
G
R
P
P
P
---------
T
L
Q
E
M
I
-------
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
K
F
V
M
D
G
-------
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
----------------------------------------------------------
500
Blastp_CBE
54.89
40%
-52
- C4 -
-
1GAG
1
A:
[11-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
G
E
A
E
--
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
S
-
K
-
G
-
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
-
R
P
E
-----
A
E
N
---
N
P
G
R
P
P
P
---------
T
L
Q
E
M
I
-------
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
K
F
V
M
D
G
-------
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
----------------------------------------------------------
451
Blastp_CBE
54.84
40%
-55
- C4 -
-
1RQQ
1
INSR_HUMAN
A:
[11-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
G
E
A
E
--
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
S
-
K
-
G
-
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
-
R
P
E
-----
A
E
N
---
N
P
G
R
P
P
P
---------
T
L
Q
E
M
I
-------
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
K
F
V
M
D
G
-------
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
----------------------------------------------------------
450
Blastp_CBE
54.41
40%
-53
- C4 -
-
1RQQ
1
B:
[11-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
G
E
A
E
--
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
S
-
K
-
G
-
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
-
R
P
E
-----
A
E
N
---
N
P
G
R
P
P
P
---------
T
L
Q
E
M
I
-------
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
D
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
-
Q
-
V
L
-
K
F
V
M
D
G
-------
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
----------------------------------------------------------
277
Blastp_CBE
54.30
54%
-22
- C4 -
-
3C7Q
1
A:
[17-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
R
---
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
---------K-
D
F
----
L
T
L
E
H
L
I
-------
Y
C
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
-
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
---
D
P
D
V
R
K
--
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
-----------------------------------------------
276
Blastp_CBE
53.15
55%
-2
- C4 -
-
3CJF
1
A:
[15-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
N
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
R
---
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
-
D
--------
D
F
----
L
T
L
E
H
L
I
-------
Y
C
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
-
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
-
D
F
-
L
A
R
D
I
Y
K
D
P
------------
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
-
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------
274
Blastp_CBE
51.79
55%
-2
- C4 -
-
3CJG
1
A:
[15-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Y
D
-
A
S
K
W
E
F
P
R
D
R
L
N
L
G
K
P
L
G
R
---
G
Q
V
I
E
A
D
A
F
G
I
-
D
K
T
A
T
R
---
T
-
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
-
K
P
G
-
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
-
R
N
E
-----
F
V
P
Y
K
-
D
L
Y
K
-----
D
F
----
L
T
L
E
H
L
I
-------
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
-
I
H
R
D
L
A
A
R
N
I
L
L
S
---
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
--------------
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
A
S
P
Y
P
G
V
K
I
D
-
E
-
E
F
C
R
R
L
K
E
G
-------
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
--------------------------------------------------
-
* C *
-
-
:
----------------------------------------------------------------------------------
-
* C *
-
-
:
----------------------------------------------------------------------------------