@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GSK3A_HUMAN: (2020-09-10 )
MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS
Atome Classification :
(498 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.------.....------.160.......170.......180.......190.......200.......210.-..-....220.......230.......240.......250.......260.......270...-----....---280.......290.......300.......310.......320.......330.......340.--.---......350...---.---....360.......370..---.....380.......390.......400.....-..410.......420.......430..--.....440.......450.......460.......470.......480.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPG
V
K
LGRDSG
K
V
T
T
V
V
A
TLGQGPERSQE
V
A
Y
T
D
I
K
V
I
GNGS
F
G
V
V
Y
Q
A
R
L
A
E
T
R
E
L
V
A
I
K
K
V
L
Q
D------KRFK
N
------
R
E
L
Q
I
M
R
K
LDHC
N
I
V
R
L
R
Y
F
F
YSSGEK
K
D
E
L
Y
L
N
L
V
L
E
Y
V
P
E
T
V
Y
R
V
A
R
H
FTKA
K
-
L
T
-
I
P
I
L
Y
V
K
V
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
SQGVCHRDIKPQ
N
L
L
VDPD
T
A
V
L
K
LCDFG
S
A
K
Q
L
VRGEP-----
N
V
S
Y
---
I
C
S
R
Y
YRA
P
E
L
I
F
GATDYTSSID
V
W
S
A
G
C
V
L
A
E
L
L
LGQPIFPGD
S
G
V
D
Q
L
V
E
I
I
K
V
LGTP
T
-
R
E
--
Q
---
I
R
EMNPN-YTEF---K---FPQIKAH
P
W
T
K
V
FKSRT
P
P
---
E
A
I
A
L
C
S
S
L
L
EYTPSSRL
S
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
C
L
GTQLPNNRPLPPLFNFSAG
E
L
S
IQP--SL
N
A
I
L
IPPHLRSPAGT
T
T
LTPSSQALTETPTSSDWQSTDATPTLTNSS
125
Blastp_CBE
96.10
85%
-128
- C2 -
-
1H8F
2
GSK3B_HUMAN
A:
[1-352]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
G
------
K
A
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
A
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
----------------------------------
124
Blastp_CBE
95.38
85%
-129
- C2 -
-
1H8F
2
GSK3B_HUMAN
B:
[1-350]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
G
------
K
A
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
A
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
101
Blastp_CBE
95.09
86%
-127
- C2 -
-
3SD0
2
GSK3B_HUMAN
B:
[1-349]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
46
Blastp_CBE
94.77
83%
-125
- C2 -
-
1J1C
1
GSK3B_HUMAN
B:
[28-386]
------------------------------------------------------------------------------------------
V
S
R
D
K
D
G
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
----------------------------------
66
Blastp_CBE
94.67
85%
-128
- C2 -
-
4NM5
5
GSK3B_HUMAN
A:
[16-371]
------------------------------------------------------------------------------------------
V
S
R
D
K
D
G
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
12
PsiBlast_PDB
94.63
82%
-120
- C2 -
-
3I4B
1
GSK3B_HUMAN
A:
[20-379]
------------------------------------------------------------------------------------------
V
S
R
D
K
D
G
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
-----------------------------------
113
Blastp_CBE
94.44
86%
-127
- C2 -
-
2OW3
1
GSK3B_HUMAN
B:
[1-352]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
----------------------------------
120
Blastp_CBE
94.40
86%
-128
- C2 -
-
6HK3
5
GSK3B_HUMAN
A:
[1-349]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
119
Blastp_CBE
94.39
86%
-127
- C2 -
-
6HK3
4
GSK3B_HUMAN
B:
[1-349]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
20
PsiBlast_PDB
94.29
82%
-128
- C2 -
-
1J1C
1
GSK3B_HUMAN
A:
[35-388]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
A
A
--------------------------------
117
Blastp_CBE
94.28
86%
-127
- C2 -
-
6HK4
10
GSK3B_HUMAN
B:
[1-349]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
129
Blastp_CBE
94.05
85%
-128
- C2 -
-
1O9U
1
GSK3B_HUMAN
A:
[1-349]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
G
------
K
A
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
A
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
A
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
47
Blastp_CBE
94.04
83%
-121
- C2 -
-
1J1B
1
GSK3B_HUMAN
B:
[28-386]
------------------------------------------------------------------------------------------
V
S
R
D
K
D
G
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
----------------------------------
60
Blastp_CBE
94.02
81%
-125
- C2 -
-
4NM0
7
GSK3B_HUMAN
A:
[26-383]
----------------------------------------------------------------------------------------
M
K
V
S
R
D
---
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
115
Blastp_CBE
93.94
86%
-127
- C2 -
-
1UV5
1
GSK3B_HUMAN
A:
[1-348]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
G
------
K
A
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
55
Blastp_CBE
93.93
84%
-133
- C2 -
-
2O5K
1
GSK3B_HUMAN
A:
[14-363]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
79
Blastp_CBE
93.90
83%
-128
- C2 -
-
4J71
1
GSK3B_HUMAN
B:
[40-387]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
19
PsiBlast_PDB
93.84
82%
-127
- C2 -
-
1J1B
1
GSK3B_HUMAN
A:
[35-388]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
A
A
--------------------------------
63
Blastp_CBE
93.80
83%
-125
- C2 -
-
3SAY
3
GSK3B_HUMAN
B:
[35-382]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
35
Blastp_CBE
93.74
83%
-125
- C2 -
-
6H0U
3
GSK3B_HUMAN
B:
[36-383]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
118
Blastp_CBE
93.67
86%
-125
- C2 -
-
6HK4
9
GSK3B_HUMAN
A:
[1-349]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
98
Blastp_CBE
93.66
86%
-123
- C2 -
-
4B7T
1
GSK3B_HUMAN
A:
[1-349]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
108
Blastp_CBE
93.56
86%
-132
- C2 -
-
5F94
1
GSK3B_HUMAN
A:
[1-346]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
---------------------------------------
36
Blastp_CBE
93.29
83%
-123
- C2 -
-
6H0U
4
GSK3B_HUMAN
A:
[36-383]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
107
Blastp_CBE
93.27
86%
-127
- C2 -
-
5F94
1
GSK3B_HUMAN
B:
[2-348]
---------------------------------------------------------------------------------------------------
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
14
PsiBlast_PDB
93.22
82%
-130
- C2 -
-
6GJO
1
GSK3B_HUMAN
A:
[29-377]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
80
Blastp_CBE
93.07
83%
-129
- C2 -
-
4J71
1
GSK3B_HUMAN
A:
[40-387]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
96
Blastp_CBE
92.95
84%
-123
- C2 -
-
3ZRK
2
GSK3B_HUMAN
B:
[14-362]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
92
Blastp_CBE
92.92
84%
-123
- C2 -
-
3ZRM
2
GSK3B_HUMAN
B:
[14-361]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
70
Blastp_CBE
92.41
83%
-122
- C2 -
-
5OY4
1
GSK3B_HUMAN
A:
[36-385]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
-----------------------------------
94
Blastp_CBE
92.32
84%
-122
- C2 -
-
3ZRL
3
GSK3B_HUMAN
B:
[14-361]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
77
Blastp_CBE
91.92
83%
-123
- C2 -
-
5HLN
3
GSK3B_HUMAN
B:
[41-387]
---------------------------------------------------------------------------------------------------
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
25
Blastp_CBE
91.85
76%
-129
- C2 -
-
4ACC
2
GSK3B_HUMAN
B:
[80-429]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
5
PsiBlast_PDB
91.83
75%
-125
- C2 -
-
4ACH
1
GSK3B_HUMAN
A:
[80-429]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
121
Blastp_CBE
91.77
86%
-120
- C2 -
-
3ZDI
1
GSK3B_HUMAN
A:
[2-349]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
22
Blastp_CBE
91.74
76%
-126
- C2 -
-
4ACH
1
GSK3B_HUMAN
B:
[80-429]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
33
Blastp_CBE
91.55
83%
-120
- C2 -
-
3I4B
1
GSK3B_HUMAN
B:
[30-376]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
126
Blastp_CBE
91.51
86%
-123
- C2 -
-
6HK7
3
GSK3B_HUMAN
A:
[1-346]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
---------------------------------------
2
PsiBlast_PDB
91.49
75%
-126
- C2 -
-
4ACC
3
GSK3B_HUMAN
A:
[80-429]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
23
Blastp_CBE
91.23
76%
-123
- C2 -
-
4ACG
1
GSK3B_HUMAN
B:
[80-429]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
3
PsiBlast_PDB
91.22
75%
-126
- C2 -
-
4ACD
1
GSK3B_HUMAN
A:
[80-429]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
99
Blastp_CBE
91.04
84%
-122
- C2 -
-
4AFJ
5
GSK3B_HUMAN
B:
[8-358]
------------------------------------------------------------------------------------------------
G
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
----------
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
67
Blastp_CBE
91.02
83%
-128
- C2 -
-
6V6L
1
?
A:
[37-384]
---------------------------------------------------------------------------------------------------
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
----------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
44
Blastp_CBE
90.94
83%
-122
- C2 -
-
2JLD
1
GSK3B_HUMAN
B:
[35-384]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
-------
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
24
Blastp_CBE
90.81
76%
-125
- C2 -
-
4ACD
1
GSK3B_HUMAN
B:
[80-429]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
42
Blastp_CBE
90.72
83%
-127
- C2 -
-
3M1S
1
GSK3B_HUMAN
B:
[35-384]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
-------
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
4
PsiBlast_PDB
90.72
75%
-122
- C2 -
-
4ACG
1
GSK3B_HUMAN
A:
[80-429]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
62
Blastp_CBE
89.45
85%
-134
- C2 -
-
4NM3
6
GSK3B_HUMAN
A:
[28-383]
------------------------------------------------------------------------------------------
V
S
R
----
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
--
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
539
HHSearch
89.27
87%
-134
- C2 -
-
1J1B
1
GSK3B_HUMAN
A:
[50-379]
----------------------------------------------------------------------------------------------------------------
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
-----------------------------------------
65
Blastp_CBE
88.56
85%
-126
- C2 -
-
4NM7
5
GSK3B_HUMAN
A:
[16-371]
------------------------------------------------------------------------------------------
V
S
R
D
---
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
--
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
114
Blastp_CBE
88.48
86%
-131
- C2 -
-
2OW3
1
GSK3B_HUMAN
A:
[1-351]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
----
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
-----------------------------------
78
Blastp_CBE
88.04
83%
-134
- C2 -
-
5HLN
3
GSK3B_HUMAN
A:
[38-388]
------------------------------------------------------------------------------------------------
G
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
43
Blastp_CBE
88.02
83%
-130
- C2 -
-
3M1S
1
GSK3B_HUMAN
A:
[35-385]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
-----
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
-----------------------------------
106
Blastp_CBE
87.79
86%
-128
- C2 -
-
5F95
1
GSK3B_HUMAN
A:
[1-348]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
----
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
69
Blastp_CBE
87.59
83%
-116
- C2 -
-
5OY4
1
GSK3B_HUMAN
B:
[30-384]
--------------------------------------------------------------------------------------------
R
D
K
D
G
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
-
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
38
Blastp_CBE
87.54
83%
-126
- C2 -
-
4PTE
1
GSK3B_HUMAN
B:
[57-406]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
---
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
-----------------------------------
105
Blastp_CBE
87.52
86%
-128
- C2 -
-
5F95
1
GSK3B_HUMAN
B:
[1-348]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-------------------
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
39
Blastp_CBE
87.50
83%
-130
- C2 -
-
4PTC
1
GSK3B_HUMAN
B:
[56-406]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
-----------------------------------
41
Blastp_CBE
87.44
83%
-127
- C2 -
-
3PUP
1
GSK3B_HUMAN
A:
[35-382]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
-
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
15
PsiBlast_PDB
87.30
82%
-136
- C2 -
-
4PTC
1
GSK3B_HUMAN
A:
[57-402]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
---------------------------------------
71
Blastp_CBE
87.17
83%
-132
- C2 -
-
5KPM
1
GSK3B_HUMAN
B:
[40-388]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
---
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
16
PsiBlast_PDB
87.06
82%
-129
- C2 -
-
4PTE
1
GSK3B_HUMAN
A:
[57-403]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
--------
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
40
Blastp_CBE
87.00
83%
-126
- C2 -
-
3PUP
1
GSK3B_HUMAN
B:
[35-383]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
-
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
97
Blastp_CBE
86.96
84%
-124
- C2 -
-
3ZRK
3
GSK3B_HUMAN
A:
[14-362]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
--
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
----
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
64
Blastp_CBE
86.90
83%
-130
- C2 -
-
3SAY
4
GSK3B_HUMAN
A:
[35-384]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
--
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
68
Blastp_CBE
86.78
83%
-129
- C2 -
-
6B8J
2
GSK3B_HUMAN
A:
[37-384]
---------------------------------------------------------------------------------------------------
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
---
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
95
Blastp_CBE
86.74
84%
-124
- C2 -
-
3ZRL
2
GSK3B_HUMAN
A:
[14-362]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
--
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
----
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
72
Blastp_CBE
86.74
83%
-133
- C2 -
-
5KPM
1
GSK3B_HUMAN
A:
[40-387]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
---
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
76
Blastp_CBE
86.64
83%
-123
- C2 -
-
5KPK
1
GSK3B_HUMAN
A:
[39-388]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
---
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
45
Blastp_CBE
86.63
83%
-124
- C2 -
-
2JLD
1
GSK3B_HUMAN
A:
[35-385]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
-
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
-----------------------------------
93
Blastp_CBE
86.62
84%
-126
- C2 -
-
3ZRM
2
GSK3B_HUMAN
A:
[14-361]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
--
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
----
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
75
Blastp_CBE
86.60
83%
-129
- C2 -
-
5KPK
1
GSK3B_HUMAN
B:
[39-387]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
11
PsiBlast_PDB
86.59
82%
-129
- C2 -
-
1Q5K
1
GSK3B_HUMAN
A:
[29-378]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
--
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
----
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
540
HHSearch
86.36
87%
-141
- C2 -
-
4NM3
6
GSK3B_HUMAN
A:
[50-383]
----------------------------------------------------------------------------------------------------------------
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
--
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
34
Blastp_CBE
86.22
83%
-123
- C2 -
-
1Q5K
1
GSK3B_HUMAN
B:
[29-378]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
----
E
F
---
K
---
F
P
---
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
112
Blastp_CBE
86.21
85%
-136
- C2 -
-
5K5N
1
GSK3B_HUMAN
A:
[22-368]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
---
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
-----------
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
---------
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
52
Blastp_CBE
86.19
83%
-125
- C2 -
-
1PYX
1
GSK3B_HUMAN
A:
[37-388]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-----
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
-----
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
----------------------------------
31
Blastp_CBE
86.14
83%
-135
- C2 -
-
6GJO
1
GSK3B_HUMAN
B:
[29-377]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
------
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
127
Blastp_CBE
86.13
86%
-130
- C2 -
-
3F88
1
GSK3B_HUMAN
B:
[1-349]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
------
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
---
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
100
Blastp_CBE
86.13
84%
-123
- C2 -
-
4AFJ
4
GSK3B_HUMAN
A:
[10-358]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
---------
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
--
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
----
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
73
Blastp_CBE
85.56
83%
-128
- C2 -
-
5KPL
1
GSK3B_HUMAN
B:
[40-387]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
---
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
------------
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
7
PsiBlast_PDB
85.56
78%
-128
- C2 -
-
1Q3W
1
GSK3B_HUMAN
A:
[39-390]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
----
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
--------
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
----------------------------------
116
Blastp_CBE
85.43
86%
-128
- C2 -
-
3GB2
1
GSK3B_HUMAN
A:
[5-353]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-----
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
----
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
122
Blastp_CBE
85.42
86%
-131
- C2 -
-
3F7Z
1
GSK3B_HUMAN
B:
[2-350]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
------
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
----------
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
128
Blastp_CBE
85.30
86%
-123
- C2 -
-
3F88
1
GSK3B_HUMAN
A:
[1-349]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
------
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
---
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
111
Blastp_CBE
85.11
85%
-131
- C2 -
-
5K5N
1
GSK3B_HUMAN
B:
[22-369]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
---
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
-----------
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-------------
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
49
Blastp_CBE
85.01
83%
-129
- C2 -
-
3DU8
1
GSK3B_HUMAN
B:
[37-387]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
------
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
-------------
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
-----------------------------------
74
Blastp_CBE
84.82
83%
-128
- C2 -
-
5KPL
1
GSK3B_HUMAN
A:
[40-388]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
--
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
--------------
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
29
Blastp_CBE
84.81
79%
-127
- C2 -
-
1Q3W
1
GSK3B_HUMAN
B:
[39-387]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
---
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
---------
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
50
Blastp_CBE
84.70
83%
-128
- C2 -
-
3DU8
1
GSK3B_HUMAN
A:
[37-384]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
------
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
-------------
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
10
PsiBlast_PDB
84.60
78%
-127
- C2 -
-
3Q3B
1
GSK3B_HUMAN
A:
[39-390]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
----
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
--------
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
----------------------------------
51
Blastp_CBE
84.47
83%
-128
- C2 -
-
1PYX
1
GSK3B_HUMAN
B:
[37-385]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-----
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
-------
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
26
Blastp_CBE
84.35
79%
-125
- C2 -
-
3Q3B
1
GSK3B_HUMAN
B:
[39-387]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
---
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
---------
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
110
Blastp_CBE
84.34
82%
-133
- C2 -
-
5HLP
1
GSK3B_HUMAN
A:
[40-386]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-----
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
----
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
6
PsiBlast_PDB
84.26
78%
-132
- C2 -
-
1Q3D
1
GSK3B_HUMAN
A:
[39-389]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
------
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
-------------
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
-----------------------------------
30
Blastp_CBE
84.24
79%
-130
- C2 -
-
1Q3D
1
GSK3B_HUMAN
B:
[39-387]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
-------------
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
17
PsiBlast_PDB
84.17
82%
-135
- C2 -
-
4PTG
1
GSK3B_HUMAN
A:
[57-403]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
------
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
---------------
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
104
Blastp_CBE
84.03
84%
-120
- C2 -
-
6GN1
1
GSK3B_HUMAN
A:
[11-358]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-----
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
---------
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
103
Blastp_CBE
83.94
84%
-119
- C2 -
-
6GN1
1
GSK3B_HUMAN
B:
[11-358]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-----
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
---------
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
123
Blastp_CBE
83.85
86%
-121
- C2 -
-
3F7Z
1
GSK3B_HUMAN
A:
[2-350]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
---
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
--------------
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
58
Blastp_CBE
83.65
83%
-134
- C2 -
-
5T31
1
GSK3B_HUMAN
B:
[36-382]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
------
V
Y
L
N
L
V
L
E
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
--------------
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
109
Blastp_CBE
83.60
82%
-130
- C2 -
-
5HLP
1
GSK3B_HUMAN
B:
[40-387]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
-----
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-------------
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
21
Blastp_CBE
83.43
78%
-140
- C2 -
-
4IQ6
1
GSK3B_HUMAN
B:
[43-388]
---------------------------------------------------------------------------------------------------
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
------
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
---------------
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
37
Blastp_CBE
83.41
83%
-132
- C2 -
-
4PTG
1
GSK3B_HUMAN
B:
[58-406]
---------------------------------------------------------------------------------------------------
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
--------------------
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
-----------------------------------
9
PsiBlast_PDB
83.15
78%
-127
- C2 -
-
1Q4L
1
GSK3B_HUMAN
A:
[39-390]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
---
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
--------------
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
----------------------------------
32
Blastp_CBE
83.11
83%
-131
- C2 -
-
3L1S
1
GSK3B_HUMAN
B:
[30-376]
--------------------------------------------------------------------------------------------------
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
--
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
----------------------
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
59
Blastp_CBE
82.52
83%
-134
- C2 -
-
5T31
1
GSK3B_HUMAN
A:
[35-381]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
---
K
D
E
V
Y
L
N
L
V
L
E
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
----------------
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
---------------------------------------
543
HHSearch
82.31
89%
-132
- C2 -
-
4B7T
1
GSK3B_HUMAN
A:
[14-317]
--------------------------------------------------------------------------------------------------------------
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
-----------------------------------------------------------------------
27
Blastp_CBE
82.16
79%
-125
- C2 -
-
1Q4L
1
GSK3B_HUMAN
B:
[39-387]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
---
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
---------------
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
13
PsiBlast_PDB
81.51
82%
-127
- C2 -
-
3L1S
1
GSK3B_HUMAN
A:
[22-378]
------------------------------------------------------------------------------------------
V
S
R
D
---
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
-------
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
---------------------
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
85
Blastp_CBE
79.88
82%
-128
- C2 -
-
4DIT
1
GSK3B_HUMAN
A:
[13-365]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
----
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
----
I
---
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
-----------------------
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
A
---------------------------------
1
PsiBlast_PDB
79.86
77%
-134
- C2 -
-
4IQ6
1
GSK3B_HUMAN
A:
[43-388]
---------------------------------------------------------------------------------------------------
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
--------
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
---------------------
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
--------------------------------------
541
HHSearch
79.29
88%
-125
- C2 -
-
4AFJ
4
GSK3B_HUMAN
A:
[20-337]
------------------------------------------------------------------------------------------------------------
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
---------
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
--
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
----
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
-----------------------------------------------------------
131
Blastp_CBE
64.87
47%
-144
- C2 -
-
3EB0
3
?
A:
[13-373]
--------------------------------------------------------------------------------------------------------------------------
K
T
L
G
T
G
-
F
G
I
V
C
E
V
F
D
I
E
S
G
K
R
F
A
L
K
K
V
L
Q
D
------
P
R
Y
K
N
------
R
E
L
D
I
M
K
V
L
D
H
V
N
I
I
K
L
V
D
Y
F
Y
T
T
-----
N
K
Y
L
N
V
I
M
E
Y
V
P
D
T
L
H
K
V
L
K
S
F
I
R
S
G
-
R
S
-
I
P
M
N
L
I
S
I
Y
I
Y
Q
L
F
R
A
V
G
F
I
H
S
L
G
I
C
H
R
D
I
K
P
Q
N
L
L
V
N
S
K
D
N
T
L
K
L
C
D
F
G
S
A
K
K
L
I
P
S
E
P
-----
S
V
A
Y
---
I
C
S
R
F
Y
R
A
P
E
L
M
L
G
A
T
E
Y
T
P
S
I
D
L
W
S
I
G
C
V
F
G
E
L
I
L
G
K
P
L
F
S
G
E
T
S
I
D
Q
L
V
R
I
I
Q
I
M
G
T
P
T
-
K
E
--
Q
---
M
I
R
M
N
P
H
-
Y
--
V
---
R
---
F
P
T
L
K
A
K
D
W
R
K
I
L
P
E
G
T
P
S
---
L
A
I
D
L
L
E
Q
I
L
R
Y
E
P
D
L
R
I
N
P
Y
E
A
M
A
H
P
F
F
D
H
L
R
N
S
----------
I
P
Q
L
F
N
F
S
P
Y
E
L
S
I
I
P
GN
V
L
N
R
I
L
-------------------------------------------
61
Blastp_CBE
62.69
85%
-28
- C2 -
-
4NU1
4
GSK3B_MOUSE
A:
[6-383]
------------------------------------------------------------------------------------------
V
S
R
D
K
D
G
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
K
--
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
-
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
-----
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
-
Y
T
E
F
---
K
---
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
-
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
--
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
281
Blastp_CBE
41.95
36%
-57
- C2 -
-
6Q48
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------STAI--
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-----------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
409
Blastp_CBE
41.49
36%
-58
- C2 -
-
4EK6
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------STAI--
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
---------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
508
Blastp_CBE
41.31
36%
-41
- C2 -
-
2A4L
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------AI----
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
466
Blastp_CBE
40.86
36%
-51
- C2 -
-
2VTA
3
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------STAI--
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
451
Blastp_CBE
40.49
36%
-63
- C2 -
-
2W05
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------STAI--
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
------------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
551
HHSearch
40.41
33%
-13
- C2 -
-
5BYZ
7
MK07_HUMAN
A:
[5-307]
-------------------------------------------------------------------------------------------------------------------
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
FDVVTN
A
K
R
T
L
------
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
----
S
-
Q
P
-
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
-
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQYF
M
T
E
Y
---
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
-
P
A
--
V
---
I
Q
A
V
G
A
E
-
R
V
R
A
YIQ
S
---
L
P
P
R
Q
P
V
P
W
E
T
-
V
Y
P
G
A
D
R
---
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
-
D
P
D
---------------------------------------------------------------------------
546
HHSearch
40.30
33%
-12
- C2 -
-
4IC7
1
MK07_HUMAN
A:
[54-357]
-------------------------------------------------------------------------------------------------------------------
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
FDVVTN
A
K
R
T
L
------
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
----
S
-
Q
P
-
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
-
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQYF
M
T
E
Y
---
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
-
P
A
--
V
---
I
Q
A
V
G
A
E
-
R
V
R
A
---
Y
IQS
L
P
P
R
Q
P
V
P
W
E
T
-
V
Y
P
G
A
D
R
---
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
-
D
P
D
D
--------------------------------------------------------------------------
488
Blastp_CBE
40.30
36%
-31
- C2 -
-
2C6I
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
465
Blastp_CBE
40.20
36%
-47
- C2 -
-
2VTH
2
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------STAI--
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
473
Blastp_CBE
40.25
36%
-24
- C2 -
-
2R3R
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
435
Blastp_CBE
40.20
36%
-22
- C2 -
-
3F5X
2
CDK2_HUMAN
C:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
273
Blastp_CBE
40.04
36%
-36
- C2 -
-
6Q4J
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------STAI--
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-------
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
512
Blastp_CBE
39.91
36%
-24
- C2 -
-
1Y8Y
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
497
Blastp_CBE
39.89
36%
-18
- C2 -
-
2C5O
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
550
HHSearch
39.88
33%
-16
- C2 -
-
4ZSG
6
MK07_HUMAN
A:
[6-308]
-------------------------------------------------------------------------------------------------------------------
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
FDVVTN
A
K
R
T
L
------
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
----
S
-
Q
P
-
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
-
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQYF
M
T
E
Y
---
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
-
P
A
--
V
---
I
Q
A
V
G
A
E
-
R
V
R
A
YIQ
S
---
L
P
P
R
Q
P
V
P
W
E
T
-
V
Y
P
G
A
D
R
---
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
-
D
P
D
---------------------------------------------------------------------------
393
Blastp_CBE
39.87
36%
-17
- C2 -
-
4FX3
1
CDK2_HUMAN
C:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
457
Blastp_CBE
39.77
36%
-50
- C2 -
-
2VTQ
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------STAI--
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
443
Blastp_CBE
39.77
36%
-20
- C2 -
-
2XMY
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
---
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
386
Blastp_CBE
39.73
36%
-41
- C2 -
-
5ANI
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------STAI--
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
384
Blastp_CBE
39.72
36%
-48
- C2 -
-
5ANK
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------STAI--
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
----------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
-------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
487
Blastp_CBE
39.64
36%
-23
- C2 -
-
2C6K
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
401
Blastp_CBE
39.69
36%
-27
- C2 -
-
4FKQ
2
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
429
Blastp_CBE
39.64
36%
-31
- C2 -
-
3LFQ
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------STAI--
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
499
Blastp_CBE
39.55
36%
-15
- C2 -
-
2C5N
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
377
Blastp_CBE
39.58
36%
-31
- C2 -
-
5JQ5
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------STAI--
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
425
Blastp_CBE
39.56
36%
-34
- C2 -
-
3SW4
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
485
Blastp_CBE
39.55
36%
-25
- C2 -
-
2C6M
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
459
Blastp_CBE
39.54
36%
-33
- C2 -
-
2VTO
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--------------HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
480
Blastp_CBE
39.51
36%
-58
- C2 -
-
2FVD
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------------
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
--
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
436
Blastp_CBE
39.49
36%
-15
- C2 -
-
3F5X
2
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
-
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
490
Blastp_CBE
39.46
36%
-23
- C2 -
-
2C68
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
468
Blastp_CBE
39.45
36%
-24
- C2 -
-
2UZO
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
434
Blastp_CBE
39.43
36%
-30
- C2 -
-
3FZ1
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-----------HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
404
Blastp_CBE
39.38
36%
-19
- C2 -
-
4FKL
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
363
Blastp_CBE
39.38
36%
-19
- C2 -
-
3PXZ
3
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
491
Blastp_CBE
39.37
36%
-27
- C2 -
-
2C5Y
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-------------
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
361
Blastp_CBE
39.34
36%
-20
- C2 -
-
3PY1
4
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
471
Blastp_CBE
39.33
36%
-12
- C2 -
-
2UUE
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
486
Blastp_CBE
39.26
36%
-25
- C2 -
-
2C6L
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
476
Blastp_CBE
39.28
36%
-22
- C2 -
-
2R3F
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
469
Blastp_CBE
39.21
36%
-41
- C2 -
-
2UZN
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
293
Blastp_CBE
39.26
36%
-40
- C2 -
-
3RPY
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
406
Blastp_CBE
39.19
36%
-27
- C2 -
-
4FKI
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
--------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
279
Blastp_CBE
39.19
36%
-23
- C2 -
-
6Q4A
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-----------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
-
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
285
Blastp_CBE
39.21
36%
-21
- C2 -
-
4GCJ
5
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
505
Blastp_CBE
39.20
36%
-22
- C2 -
-
2B54
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
274
Blastp_CBE
39.19
36%
-25
- C2 -
-
6Q4H
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-----------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-------
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
462
Blastp_CBE
39.13
36%
-22
- C2 -
-
2VTL
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
385
Blastp_CBE
39.18
36%
-23
- C2 -
-
5ANJ
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
-----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
442
Blastp_CBE
39.15
36%
-17
- C2 -
-
2XNB
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
447
Blastp_CBE
39.14
36%
-16
- C2 -
-
2WEV
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
392
Blastp_CBE
39.13
36%
-18
- C2 -
-
4KD1
2
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
467
Blastp_CBE
39.05
36%
-20
- C2 -
-
2V0D
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
484
Blastp_CBE
39.03
36%
-21
- C2 -
-
2C6O
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
402
Blastp_CBE
39.08
36%
-36
- C2 -
-
4FKP
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
449
Blastp_CBE
39.06
36%
-41
- C2 -
-
2W17
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
-
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-----------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
-
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
427
Blastp_CBE
39.05
36%
-24
- C2 -
-
3NS9
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-------------
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
547
HHSearch
38.95
33%
-32
- C2 -
-
4B99
1
MK07_HUMAN
A:
[53-355]
-------------------------------------------------------------------------------------------------------------------
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
FDVVTN
A
K
R
T
L
------
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
----
S
-
Q
P
-
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
-
C
E
L
K
I
G
D
F
G
M
A
R
G
L
-----QYF--
M
T
E
Y
---
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
-
P
A
--
V
---
I
Q
-----R
V
R
A
Y
IQ-
S
---
L
P
P
R
Q
P
V
P
W
E
T
-
V
Y
P
G
A
D
R
---
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
-
D
P
D
---------------------------------------------------------------------------
461
Blastp_CBE
39.04
36%
-20
- C2 -
-
2VTM
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
420
Blastp_CBE
39.03
36%
-27
- C2 -
-
3ULI
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-----------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
----------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
445
Blastp_CBE
38.95
36%
-17
- C2 -
-
2X1N
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
307
Blastp_CBE
39.00
36%
-43
- C2 -
-
3RAL
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
507
Blastp_CBE
38.99
36%
-41
- C2 -
-
2B52
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
-----------------HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
444
Blastp_CBE
38.98
36%
-15
- C2 -
-
2X1N
1
CDK2_HUMAN
C:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
289
Blastp_CBE
38.95
36%
-40
- C2 -
-
3S1H
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
450
Blastp_CBE
38.94
36%
-29
- C2 -
-
2W06
2
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
464
Blastp_CBE
38.92
36%
-29
- C2 -
-
2VTI
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
531
Blastp_CBE
38.83
36%
-31
- C2 -
-
1KE9
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
470
Blastp_CBE
38.83
36%
-14
- C2 -
-
2UUE
1
CDK2_HUMAN
C:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
500
Blastp_CBE
38.80
36%
-43
- C2 -
-
2BTS
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------STAI--
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
411
Blastp_CBE
38.87
36%
-18
- C2 -
-
4EK4
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
496
Blastp_CBE
38.79
36%
-8
- C2 -
-
2C5O
1
CDK2_HUMAN
C:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
407
Blastp_CBE
38.83
36%
-27
- C2 -
-
4FKG
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
--------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
395
Blastp_CBE
38.82
36%
-33
- C2 -
-
4FKW
2
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
314
Blastp_CBE
38.80
36%
-24
- C2 -
-
3R9D
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
474
Blastp_CBE
38.79
36%
-19
* C2 *
-
2R3H
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
481
Blastp_CBE
38.77
36%
-14
- C2 -
-
2EXM
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
537
Blastp_CBE
38.67
36%
-17
- C2 -
-
1JSV
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------TAI---
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
510
Blastp_CBE
38.74
36%
-16
- C2 -
-
1YKR
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
452
Blastp_CBE
38.73
36%
-36
- C2 -
-
2VV9
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
514
Blastp_CBE
38.63
36%
-26
- C2 -
-
1W0X
1
CDK2_HUMAN
C:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
387
Blastp_CBE
38.71
36%
-51
- C2 -
-
5ANG
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------STAI--
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
432
Blastp_CBE
38.65
36%
-20
- C2 -
-
3IGG
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
424
Blastp_CBE
38.65
36%
-40
- C2 -
-
3SW7
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
489
Blastp_CBE
38.63
36%
-21
- C2 -
-
2C69
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
272
Blastp_CBE
38.69
36%
-23
- C2 -
-
6Q4K
3
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
498
Blastp_CBE
38.60
36%
-12
- C2 -
-
2C5N
1
CDK2_HUMAN
C:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
492
Blastp_CBE
38.67
36%
-9
- C2 -
-
2C5X
1
CDK2_HUMAN
C:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
321
Blastp_CBE
38.65
36%
-23
- C2 -
-
3R83
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
394
Blastp_CBE
38.64
36%
-14
- C2 -
-
4FX3
2
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
418
Blastp_CBE
38.59
36%
-20
- C2 -
-
3UNK
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
337
Blastp_CBE
38.63
36%
-24
- C2 -
-
3QZF
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
535
Blastp_CBE
38.53
36%
-28
- C2 -
-
1KE5
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
483
Blastp_CBE
38.61
36%
-22
- C2 -
-
2CLX
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
391
Blastp_CBE
38.60
36%
-24
- C2 -
-
4LYN
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
308
Blastp_CBE
38.59
36%
-44
- C2 -
-
3RAK
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
506
Blastp_CBE
38.50
36%
-27
- C2 -
-
2B53
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
410
Blastp_CBE
38.54
36%
-19
- C2 -
-
4EK5
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
350
Blastp_CBE
38.53
36%
-31
- C2 -
-
3QTR
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
475
Blastp_CBE
38.46
36%
-16
- C2 -
-
2R3G
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------TAI---
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
349
Blastp_CBE
38.50
36%
-28
- C2 -
-
3QTS
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
495
Blastp_CBE
38.42
36%
-11
- C2 -
-
2C5V
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
380
Blastp_CBE
38.49
36%
-24
- C2 -
-
5IEV
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
399
Blastp_CBE
38.42
36%
-34
- C2 -
-
4FKS
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
524
Blastp_CBE
38.37
36%
-24
- C2 -
-
1PXL
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
527
Blastp_CBE
38.45
36%
-21
- C2 -
-
1PXI
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
320
Blastp_CBE
38.42
36%
-24
- C2 -
-
3R8L
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
501
Blastp_CBE
38.40
36%
-31
- C2 -
-
2BTR
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------TAI---
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
-----------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
529
Blastp_CBE
38.31
36%
-41
- C2 -
-
1P2A
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------AI----
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
523
Blastp_CBE
38.39
36%
-17
- C2 -
-
1PXM
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
456
Blastp_CBE
38.37
36%
-19
- C2 -
-
2VTR
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
284
Blastp_CBE
38.35
36%
-39
- C2 -
-
6GUH
3
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------STAI--
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
---------------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
478
Blastp_CBE
38.34
36%
-15
- C2 -
-
2I40
1
CDK2_HUMAN
C:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
509
Blastp_CBE
38.33
36%
-22
- C2 -
-
2A0C
1
CDK2_HUMAN
X:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
533
Blastp_CBE
38.32
36%
-28
- C2 -
-
1KE7
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
222
Blastp_CBE
38.31
36%
-36
- C2 -
-
3EZV
1
CDK2_HUMAN
A:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
328
Blastp_CBE
38.30
36%
-20
- C2 -
-
3R71
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
502
Blastp_CBE
38.21
36%
-34
- C2 -
-
2BHH
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
460
Blastp_CBE
38.27
36%
-30
- C2 -
-
2VTN
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
430
Blastp_CBE
38.21
36%
-33
- C2 -
-
3LFN
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
---------------HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
295
Blastp_CBE
38.26
36%
-26
- C2 -
-
3RPR
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
528
Blastp_CBE
38.17
36%
-19
- C2 -
-
1PF8
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
515
Blastp_CBE
38.25
36%
-26
- C2 -
-
1VYZ
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------TAI---
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-----------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
286
Blastp_CBE
38.23
36%
-13
- C2 -
-
4EZ7
7
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
446
Blastp_CBE
38.17
36%
-10
- C2 -
-
2WEV
1
CDK2_HUMAN
C:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
417
Blastp_CBE
38.18
36%
-27
- C2 -
-
3WBL
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
-
T
G
E
V
V
A
L
K
K
I
R
L
-----------
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
303
Blastp_CBE
38.22
36%
-22
- C2 -
-
3RK9
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
299
Blastp_CBE
38.21
36%
-43
- C2 -
-
3RMF
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
405
Blastp_CBE
38.14
36%
-34
- C2 -
-
4FKJ
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
253
Blastp_CBE
38.18
36%
-25
- C2 -
-
6Q4G
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
E
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-----------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
378
Blastp_CBE
38.14
36%
-22
- C2 -
-
5IEY
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
----------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
344
Blastp_CBE
38.17
36%
-21
- C2 -
-
3QU0
4
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
342
Blastp_CBE
38.14
36%
-23
- C2 -
-
3QWK
5
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
458
Blastp_CBE
38.12
36%
-28
- C2 -
-
2VTP
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
362
Blastp_CBE
38.10
36%
-23
- C2 -
-
3PY0
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
228
Blastp_CBE
38.08
36%
-26
- C2 -
-
3PJ8
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
400
Blastp_CBE
38.09
36%
-30
- C2 -
-
4FKR
2
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
211
Blastp_CBE
38.08
35%
-2
- C2 -
-
3NIZ
1
?
A:
[23-307]
----------------------------------------------------------------------------------------------------------------------
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
S
Q
G
R
-
I
V
A
L
K
R
I
R
------------
G
IPSTAI
R
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
I
H
S
------
E
R
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
---
L
D
E
N
K
-
T
G
-
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
S
D
G
A
-
L
K
L
A
D
F
G
L
A
R
A
F
--
G
I
P
-----
V
R
--HE-
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
G
K
P
L
F
P
G
V
T
D
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
WP
Q
---
V
Q
E
L
-
P
L
-
W
K
Q
R
---
T
---
F
Q
V
F
E
K
K
P
W
S
S
I
I
P
G
F
C
-
Q
---
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
--------------------------------------------------------------------------------
372
Blastp_CBE
38.05
36%
-25
- C2 -
-
5K4J
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
---------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
381
Blastp_CBE
38.04
36%
-28
- C2 -
-
5FP6
2
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
354
Blastp_CBE
38.03
36%
-20
- C2 -
-
3QQL
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
526
Blastp_CBE
38.01
36%
-17
- C2 -
-
1PXJ
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
525
Blastp_CBE
37.92
36%
-18
- C2 -
-
1PXK
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
294
Blastp_CBE
38.00
36%
-19
- C2 -
-
3RPV
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
343
Blastp_CBE
37.98
36%
-20
- C2 -
-
3QWJ
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
329
Blastp_CBE
37.97
36%
-16
- C2 -
-
3R6X
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
493
Blastp_CBE
37.81
36%
-11
- C2 -
-
2C5X
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
532
Blastp_CBE
37.94
36%
-21
- C2 -
-
1KE8
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
--------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
357
Blastp_CBE
37.92
36%
-22
- C2 -
-
3QQH
4
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
397
Blastp_CBE
37.91
36%
-18
- C2 -
-
4FKU
3
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
322
Blastp_CBE
37.88
36%
-20
- C2 -
-
3R7Y
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
310
Blastp_CBE
37.90
36%
-24
- C2 -
-
3RAH
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
477
Blastp_CBE
37.83
36%
-33
- C2 -
-
2J9M
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
396
Blastp_CBE
37.89
36%
-26
- C2 -
-
4FKV
2
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
----------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
312
Blastp_CBE
37.88
36%
-27
- C2 -
-
3R9N
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
388
Blastp_CBE
37.87
36%
-21
- C2 -
-
5ANE
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
482
Blastp_CBE
37.80
36%
-32
- C2 -
-
2DUV
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------I-----
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
--------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
373
Blastp_CBE
37.85
36%
-33
- C2 -
-
6INL
1
?
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------TAI---
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
339
Blastp_CBE
37.83
36%
-19
- C2 -
-
3QXO
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
311
Blastp_CBE
37.81
36%
-27
- C2 -
-
3R9O
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
416
Blastp_CBE
37.80
36%
-32
- C2 -
-
4ACM
3
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
415
Blastp_CBE
37.77
36%
-36
- C2 -
-
4BGH
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
323
Blastp_CBE
37.75
36%
-19
- C2 -
-
3R7V
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
340
Blastp_CBE
37.71
36%
-20
- C2 -
-
3QX4
3
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
277
Blastp_CBE
37.73
36%
-22
- C2 -
-
6Q4C
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
520
Blastp_CBE
37.72
36%
-19
- C2 -
-
1PXP
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
334
Blastp_CBE
37.71
36%
-18
- C2 -
-
3QZI
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
419
Blastp_CBE
37.66
36%
-21
- C2 -
-
3UNJ
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
353
Blastp_CBE
37.69
36%
-20
- C2 -
-
3QRT
3
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
318
Blastp_CBE
37.68
36%
-22
- C2 -
-
3R8P
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
390
Blastp_CBE
37.64
36%
-24
- C2 -
-
5A14
2
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
414
Blastp_CBE
37.67
36%
-31
- C2 -
-
4BZD
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
327
Blastp_CBE
37.66
36%
-19
- C2 -
-
3R73
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
534
Blastp_CBE
37.57
36%
-22
- C2 -
-
1KE6
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
360
Blastp_CBE
37.64
36%
-19
- C2 -
-
3QL8
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
355
Blastp_CBE
37.62
36%
-18
- C2 -
-
3QQK
6
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
304
Blastp_CBE
37.61
36%
-21
- C2 -
-
3RK7
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
351
Blastp_CBE
37.60
36%
-20
- C2 -
-
3QTQ
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
356
Blastp_CBE
37.54
36%
-19
- C2 -
-
3QQJ
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
455
Blastp_CBE
37.57
36%
-20
- C2 -
-
2VTS
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--------------HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
306
Blastp_CBE
37.55
36%
-20
- C2 -
-
3RJC
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
403
Blastp_CBE
37.50
36%
-23
- C2 -
-
4FKO
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
317
Blastp_CBE
37.54
36%
-20
- C2 -
-
3R8U
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
479
Blastp_CBE
37.52
36%
-21
- C2 -
-
2I40
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
---
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
423
Blastp_CBE
37.46
36%
-21
- C2 -
-
3TI1
9
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
511
Blastp_CBE
37.42
36%
-27
- C2 -
-
1Y91
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
----------
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
326
Blastp_CBE
37.50
36%
-18
- C2 -
-
3R7E
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
316
Blastp_CBE
37.46
36%
-21
- C2 -
-
3R8V
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
330
Blastp_CBE
37.48
36%
-16
- C2 -
-
3R28
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
134
Blastp_CBE
37.46
37%
-32
- C2 -
-
5OO1
1
CDK2_HUMAN
A:
[9-294]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
----
E
N
K
L
Y
L
------
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
504
Blastp_CBE
37.38
36%
-29
- C2 -
-
2B55
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-------------
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
359
Blastp_CBE
37.42
36%
-18
- C2 -
-
3QQF
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
302
Blastp_CBE
37.45
36%
-20
- C2 -
-
3RKB
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
300
Blastp_CBE
37.42
36%
-19
- C2 -
-
3RM7
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
454
Blastp_CBE
37.41
36%
-33
- C2 -
-
2VTT
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------TAI---
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
336
Blastp_CBE
37.38
36%
-17
- C2 -
-
3QZG
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
298
Blastp_CBE
37.38
36%
-19
- C2 -
-
3RNI
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
431
Blastp_CBE
37.37
36%
-24
- C2 -
-
3LE6
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
389
Blastp_CBE
37.36
36%
-25
- C2 -
-
5AND
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
347
Blastp_CBE
37.32
36%
-18
- C2 -
-
3QTW
6
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
366
Blastp_CBE
37.35
36%
-19
- C2 -
-
3PXQ
4
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
313
Blastp_CBE
37.34
36%
-17
- C2 -
-
3R9H
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
422
Blastp_CBE
37.29
36%
-17
- C2 -
-
3TIY
12
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
364
Blastp_CBE
37.29
36%
-19
- C2 -
-
3PXY
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
283
Blastp_CBE
37.32
36%
-20
- C2 -
-
6GUK
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------TAI---
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
---------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
305
Blastp_CBE
37.31
36%
-20
- C2 -
-
3RK5
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
358
Blastp_CBE
37.27
36%
-18
- C2 -
-
3QQG
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
379
Blastp_CBE
37.30
36%
-17
- C2 -
-
5IEX
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----------
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
252
Blastp_CBE
37.29
37%
-34
- C2 -
-
1GII
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
----
E
N
K
L
Y
L
------
V
F
E
H
V
H
Q
D
L
K
T
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
292
Blastp_CBE
37.28
36%
-28
- C2 -
-
3RZB
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
324
Blastp_CBE
37.27
36%
-26
- C2 -
-
3R7U
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
421
Blastp_CBE
37.24
36%
-19
- C2 -
-
3TIZ
9
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
345
Blastp_CBE
37.23
36%
-20
- C2 -
-
3QTZ
3
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
494
Blastp_CBE
37.15
36%
-5
- C2 -
-
2C5V
1
CDK2_HUMAN
C:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
278
Blastp_CBE
37.22
36%
-20
- C2 -
-
6Q4B
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
348
Blastp_CBE
37.20
36%
-16
- C2 -
-
3QTU
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
352
Blastp_CBE
37.18
36%
-19
- C2 -
-
3QRU
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
398
Blastp_CBE
37.16
36%
-17
- C2 -
-
4FKT
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
408
Blastp_CBE
37.15
36%
-19
- C2 -
-
4EK8
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
413
Blastp_CBE
37.09
36%
-19
- C2 -
-
4D1X
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------TAI---
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
----------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
332
Blastp_CBE
37.08
36%
-16
- C2 -
-
3R1S
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
516
Blastp_CBE
37.06
36%
-25
- C2 -
-
1V1K
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------TAI---
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
521
Blastp_CBE
37.03
36%
-17
- C2 -
-
1PXO
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
291
Blastp_CBE
37.00
36%
-19
- C2 -
-
3S00
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
338
Blastp_CBE
36.96
36%
-20
- C2 -
-
3QXP
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
472
Blastp_CBE
36.93
36%
-22
- C2 -
-
2R64
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
287
Blastp_CBE
36.91
36%
-19
- C2 -
-
4EZ3
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
433
Blastp_CBE
36.89
36%
-19
- C2 -
-
3IG7
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
-------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
438
Blastp_CBE
36.88
36%
-15
- C2 -
-
3EOC
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
282
Blastp_CBE
36.87
36%
-29
- C2 -
-
6Q3B
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
439
Blastp_CBE
36.86
36%
-13
- C2 -
-
3EJ1
1
CDK2_HUMAN
C:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
437
Blastp_CBE
36.80
36%
-19
- C2 -
-
3EOC
1
CDK2_HUMAN
C:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
441
Blastp_CBE
36.75
36%
-14
- C2 -
-
3EID
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
T--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
376
Blastp_CBE
36.80
36%
-17
- C2 -
-
5JQ8
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
522
Blastp_CBE
36.67
36%
-19
- C2 -
-
1PXN
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
440
Blastp_CBE
36.75
36%
-17
- C2 -
-
3EJ1
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
346
Blastp_CBE
36.67
36%
-14
- C2 -
-
3QTX
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
315
Blastp_CBE
36.70
36%
-19
- C2 -
-
3R8Z
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
---------THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
223
Blastp_CBE
36.67
36%
-23
- C2 -
-
3EZR
2
CDK2_HUMAN
A:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
-------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
453
Blastp_CBE
36.62
36%
-27
- C2 -
-
2VU3
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------TAI---
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
----
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
518
Blastp_CBE
36.56
36%
-29
- C2 -
-
1R78
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------TAI---
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
513
Blastp_CBE
36.47
36%
-22
- C2 -
-
1WCC
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
412
Blastp_CBE
36.44
36%
-40
- C2 -
-
4D1Z
2
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------AI----
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
288
Blastp_CBE
36.39
36%
-21
- C2 -
-
3SQQ
2
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
-------------
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
426
Blastp_CBE
36.32
36%
-26
- C2 -
-
3S2P
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
448
Blastp_CBE
36.31
36%
-20
- C2 -
-
2W1H
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
319
Blastp_CBE
36.00
36%
-22
- C2 -
-
3R8M
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-----------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
132
Blastp_CBE
35.86
37%
-3
- C2 -
-
5OSM
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------
P
L
G
S
M
E
-
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
----
E
N
K
L
Y
L
------
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
519
Blastp_CBE
35.82
36%
-39
- C2 -
-
1PYE
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------TAI---
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
--------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
-----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
517
Blastp_CBE
35.76
36%
-26
- C2 -
-
1URW
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------TAI---
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
382
Blastp_CBE
35.63
36%
-32
- C2 -
-
5FP5
3
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------TAI---
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
-----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
275
Blastp_CBE
35.62
36%
-18
- C2 -
-
6Q4E
3
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-----------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
251
Blastp_CBE
35.43
37%
-25
- C2 -
-
1GIJ
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------AI----
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
----
E
N
K
L
Y
L
------
V
F
E
H
V
H
Q
D
L
K
T
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
290
Blastp_CBE
35.41
36%
-19
- C2 -
-
3S0O
1
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
--
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
168
Blastp_CBE
35.33
36%
-25
- C2 -
-
6GUC
1
CDK2_HUMAN
C:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
157
Blastp_CBE
35.16
36%
-15
- C2 -
-
1H1S
1
CDK2_HUMAN
C:
[5-294]
-----------------------------------------------------------------------------------------------------------------
S
M
E
-
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
236
Blastp_CBE
35.07
36%
-21
- C2 -
-
3DDP
1
CDK2_HUMAN
C:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
383
Blastp_CBE
35.02
36%
-33
- C2 -
-
5D1J
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
---------------I-----
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
262
Blastp_CBE
35.02
36%
-19
- C2 -
-
2UZB
1
CDK2_HUMAN
C:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
261
Blastp_CBE
34.87
36%
-18
- C2 -
-
2UZD
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
259
Blastp_CBE
34.82
36%
-16
- C2 -
-
2UZE
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
143
Blastp_CBE
34.84
36%
-13
- C2 -
-
4CFV
1
CDK2_HUMAN
A:
[3-294]
---------------------------------------------------------------------------------------------------------------
P
G
S
M
E
-
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
133
Blastp_CBE
34.82
37%
-10
- C2 -
-
5OO3
1
CDK2_HUMAN
A:
[7-294]
-------------------------------------------------------------------------------------------------------------------
E
-
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
----
E
N
K
L
Y
L
------
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
146
Blastp_CBE
34.80
36%
-17
- C2 -
-
5NEV
1
?
C:
[5-294]
-----------------------------------------------------------------------------------------------------------------
S
M
E
-
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
196
Blastp_CBE
34.79
36%
-20
- C2 -
-
4BCN
1
CDK2_HUMAN
A:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
244
Blastp_CBE
34.75
36%
-18
- C2 -
-
1QMZ
1
CDK2_HUMAN
C:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
230
Blastp_CBE
34.73
36%
-19
- C2 -
-
5LMK
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
216
Blastp_CBE
34.73
36%
-17
- C2 -
-
1E9H
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
159
Blastp_CBE
34.71
36%
-15
- C2 -
-
1H1R
1
CDK2_HUMAN
C:
[5-294]
-----------------------------------------------------------------------------------------------------------------
S
M
E
-
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
204
Blastp_CBE
34.60
36%
-17
- C2 -
-
3BHV
2
CDK2_HUMAN
A:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
161
Blastp_CBE
34.59
36%
-16
- C2 -
-
1H1Q
1
CDK2_HUMAN
C:
[5-294]
-----------------------------------------------------------------------------------------------------------------
S
M
E
-
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
276
Blastp_CBE
34.58
36%
-12
- C2 -
-
6Q4D
6
CDK2_HUMAN
A:
[12-297]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------PSTAI-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
226
Blastp_CBE
34.56
36%
-13
- C2 -
-
4I3Z
3
CDK2_HUMAN
C:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
220
Blastp_CBE
34.55
36%
-14
- C2 -
-
3QHR
6
CDK2_HUMAN
A:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
227
Blastp_CBE
34.53
36%
-12
- C2 -
-
4I3Z
4
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
206
Blastp_CBE
34.53
36%
-17
- C2 -
-
3BHU
1
CDK2_HUMAN
A:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
184
Blastp_CBE
34.53
36%
-34
- C2 -
-
4EOQ
1
CDK2_HUMAN
C:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
------------------------------------
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
167
Blastp_CBE
34.52
36%
-22
- C2 -
-
6GUE
1
CDK2_HUMAN
C:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
-------
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
---
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
263
Blastp_CBE
34.51
36%
-16
- C2 -
-
2UZB
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
241
Blastp_CBE
34.48
36%
-19
- C2 -
-
2CCI
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
165
Blastp_CBE
34.46
36%
-17
- C2 -
-
6GUF
1
CDK2_HUMAN
C:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
267
Blastp_CBE
34.43
36%
-15
- C2 -
-
2C6T
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
151
Blastp_CBE
34.44
36%
-15
- C2 -
-
4CFX
1
CDK2_HUMAN
A:
[5-294]
-----------------------------------------------------------------------------------------------------------------
S
M
E
-
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
148
Blastp_CBE
34.43
36%
-13
- C2 -
-
5CYI
1
CDK2_HUMAN
C:
[5-294]
-----------------------------------------------------------------------------------------------------------------
S
M
E
-
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
271
Blastp_CBE
34.40
36%
-20
- C2 -
-
1FQ1
1
CDK2_HUMAN
B:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
147
Blastp_CBE
34.38
36%
-14
- C2 -
-
5NEV
1
CDK2_HUMAN
A:
[5-294]
-----------------------------------------------------------------------------------------------------------------
S
M
E
-
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
255
Blastp_CBE
34.37
36%
-14
- C2 -
-
4II5
2
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
370
Blastp_CBE
34.31
36%
-19
- C2 -
-
2IW6
1
CDK2_HUMAN
C:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
----
K
T
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
254
Blastp_CBE
34.29
36%
-13
- C2 -
-
4II5
3
CDK2_HUMAN
C:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
209
Blastp_CBE
34.29
36%
-19
- C2 -
-
4EOS
1
CDK2_HUMAN
C:
[7-292]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
530
Blastp_CBE
34.30
36%
-32
- C2 -
-
1OIQ
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------------TAI---
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
-----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
152
Blastp_CBE
34.29
36%
-15
- C2 -
-
4CFW
1
CDK2_HUMAN
C:
[4-294]
----------------------------------------------------------------------------------------------------------------
G
S
M
E
-
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
245
Blastp_CBE
34.28
36%
-18
- C2 -
-
1QMZ
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
130
Blastp_CBE
34.25
47%
-6
- C2 -
-
3EB0
3
?
C:
[7-373]
--------------------------------------------------------------------------------------------------------------------------
K
T
L
G
T
G
S
F
G
I
V
C
E
V
F
D
I
E
S
G
K
R
F
A
L
K
K
V
L
Q
D
------
P
R
Y
K
N
------
R
E
L
D
I
M
K
V
L
D
H
V
N
I
I
K
L
V
D
Y
F
Y
T
T
G
D
E
E
-----
N
V
I
M
E
Y
V
P
D
T
L
H
K
V
L
K
S
F
I
R
S
G
-
R
S
-
I
P
M
N
L
I
S
I
Y
I
Y
Q
L
F
R
A
V
G
F
I
H
S
L
G
I
C
H
R
D
I
K
P
Q
N
L
L
V
N
S
K
D
N
T
L
K
L
C
D
F
G
S
A
K
K
L
I
P
S
E
P
-----
S
V
A
----
I
C
S
R
F
Y
R
A
P
E
L
M
L
G
A
T
E
Y
T
P
S
I
D
L
W
S
I
G
C
V
F
G
E
L
I
L
G
K
P
L
F
S
G
E
T
S
I
D
Q
L
V
R
I
I
Q
I
M
G
T
P
T
-
K
E
--
Q
---
M
I
R
M
N
P
H
-
Y
T
E
V
---
R
---
F
--
L
K
A
K
D
W
R
K
I
L
P
E
G
T
P
S
---
L
A
I
D
L
L
E
Q
I
L
R
Y
E
P
D
L
R
I
N
P
Y
E
A
M
A
H
P
F
F
D
H
L
R
N
S
Y
E
S
E
V
---------
F
N
F
S
P
Y
E
L
S
I
I
P
GN
V
L
N
R
I
L
-------------------------------------------
162
Blastp_CBE
34.20
36%
-14
- C2 -
-
1H1Q
1
CDK2_HUMAN
A:
[5-294]
-----------------------------------------------------------------------------------------------------------------
S
M
E
-
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
178
Blastp_CBE
34.19
36%
-15
- C2 -
-
1OI9
1
CDK2_HUMAN
C:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
153
Blastp_CBE
34.19
36%
-16
- C2 -
-
4CFW
1
CDK2_HUMAN
A:
[4-294]
----------------------------------------------------------------------------------------------------------------
G
S
M
E
-
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
269
Blastp_CBE
34.18
36%
-19
- C2 -
-
1JST
1
CDK2_HUMAN
C:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
218
Blastp_CBE
34.16
36%
-11
- C2 -
-
3QHW
2
CDK2_HUMAN
A:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
217
Blastp_CBE
34.14
36%
-14
- C2 -
-
3QHW
3
CDK2_HUMAN
C:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
163
Blastp_CBE
34.12
36%
-10
- C2 -
-
1H1P
1
CDK2_HUMAN
C:
[5-294]
-----------------------------------------------------------------------------------------------------------------
S
M
E
-
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
195
Blastp_CBE
34.11
36%
-15
- C2 -
-
4BCN
1
CDK2_HUMAN
C:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
257
Blastp_CBE
34.10
36%
-16
- C2 -
-
2UZL
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
219
Blastp_CBE
34.09
36%
-13
- C2 -
-
3QHR
2
CDK2_HUMAN
C:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
246
Blastp_CBE
34.08
36%
-18
- C2 -
-
1P5E
1
CDK2_HUMAN
C:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
214
Blastp_CBE
34.07
36%
-14
- C2 -
-
1PKD
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
149
Blastp_CBE
34.04
36%
-12
- C2 -
-
5CYI
1
CDK2_HUMAN
A:
[5-294]
-----------------------------------------------------------------------------------------------------------------
S
M
E
-
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
249
Blastp_CBE
34.03
36%
-17
- C2 -
-
1GY3
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
243
Blastp_CBE
34.01
36%
-16
- C2 -
-
2CCH
3
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
240
Blastp_CBE
33.99
36%
-19
- C2 -
-
2CCI
1
CDK2_HUMAN
C:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
235
Blastp_CBE
33.95
36%
-19
- C2 -
-
3DDQ
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
213
Blastp_CBE
33.94
36%
-20
- C2 -
-
1PKD
1
CDK2_HUMAN
C:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
260
Blastp_CBE
33.93
36%
-17
- C2 -
-
2UZD
1
CDK2_HUMAN
C:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
155
Blastp_CBE
33.87
36%
-10
- C2 -
-
4CFM
1
CDK2_HUMAN
A:
[5-294]
-----------------------------------------------------------------------------------------------------------------
S
M
E
-
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
140
Blastp_CBE
33.87
36%
-12
- C2 -
-
2IW8
1
CDK2_HUMAN
A:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
H
V
D
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
239
Blastp_CBE
33.83
36%
-14
- C2 -
-
2G9X
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
237
Blastp_CBE
33.83
36%
-17
- C2 -
-
3DDP
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
170
Blastp_CBE
33.83
36%
-22
- C2 -
-
6GUB
1
?
C:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
-----
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
231
Blastp_CBE
33.82
36%
-17
- C2 -
-
5L2W
2
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
242
Blastp_CBE
33.80
36%
-13
- C2 -
-
2CCH
1
CDK2_HUMAN
C:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
248
Blastp_CBE
33.78
36%
-15
- C2 -
-
1GY3
2
CDK2_HUMAN
C:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
256
Blastp_CBE
33.77
36%
-15
- C2 -
-
2UZL
1
CDK2_HUMAN
C:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
247
Blastp_CBE
33.76
36%
-14
- C2 -
-
1P5E
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
266
Blastp_CBE
33.72
36%
-16
- C2 -
-
2C6T
1
CDK2_HUMAN
C:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
150
Blastp_CBE
33.73
36%
-13
- C2 -
-
4CFX
1
CDK2_HUMAN
C:
[5-294]
-----------------------------------------------------------------------------------------------------------------
S
M
E
-
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
172
Blastp_CBE
33.72
36%
-14
- C2 -
-
4CFN
1
CDK2_HUMAN
C:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
145
Blastp_CBE
33.66
36%
-12
- C2 -
-
4CFU
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------
P
P
G
S
M
E
-
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
215
Blastp_CBE
33.65
36%
-17
- C2 -
-
1E9H
1
CDK2_HUMAN
C:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
270
Blastp_CBE
33.64
36%
-20
- C2 -
-
1JST
1
CDK2_HUMAN
A:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
186
Blastp_CBE
33.62
36%
-23
- C2 -
-
4BCQ
1
CDK2_HUMAN
C:
[7-292]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
158
Blastp_CBE
33.57
36%
-15
- C2 -
-
1H1S
1
CDK2_HUMAN
A:
[5-294]
-----------------------------------------------------------------------------------------------------------------
S
M
E
-
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
208
Blastp_CBE
33.54
36%
-18
- C2 -
-
3BHT
1
CDK2_HUMAN
A:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
199
Blastp_CBE
33.55
36%
-14
- C2 -
-
3TNW
1
CDK2_HUMAN
C:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
192
Blastp_CBE
33.54
36%
-14
- C2 -
-
4BCP
1
CDK2_HUMAN
A:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
164
Blastp_CBE
33.53
36%
-11
- C2 -
-
1H1P
1
CDK2_HUMAN
A:
[5-294]
-----------------------------------------------------------------------------------------------------------------
S
M
E
-
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
160
Blastp_CBE
33.46
36%
-11
- C2 -
-
1H1R
1
CDK2_HUMAN
A:
[5-294]
-----------------------------------------------------------------------------------------------------------------
S
M
E
-
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
194
Blastp_CBE
33.32
36%
-11
- C2 -
-
4BCO
1
CDK2_HUMAN
A:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
141
Blastp_CBE
33.32
36%
-16
- C2 -
-
6GUE
1
CDK2_HUMAN
A:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
N
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
198
Blastp_CBE
33.31
36%
-18
- C2 -
-
4BCK
2
CDK2_HUMAN
A:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
258
Blastp_CBE
33.28
36%
-16
- C2 -
-
2UZE
1
CDK2_HUMAN
C:
[4-289]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
179
Blastp_CBE
33.24
36%
-17
- C2 -
-
1OI9
1
CDK2_HUMAN
A:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
188
Blastp_CBE
33.15
36%
-15
- C2 -
-
4BCM
1
CDK2_HUMAN
C:
[7-292]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
197
Blastp_CBE
33.14
36%
-22
- C2 -
-
4BCK
1
CDK2_HUMAN
C:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
238
Blastp_CBE
33.12
36%
-25
- C2 -
-
2G9X
1
CDK2_HUMAN
C:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
------------------------------------
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
200
Blastp_CBE
33.12
36%
-22
- C2 -
-
3TNW
1
CDK2_HUMAN
A:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
225
Blastp_CBE
33.09
36%
-18
- C2 -
-
4EOR
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
174
Blastp_CBE
33.05
36%
-11
- C2 -
-
1OIY
1
CDK2_HUMAN
C:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
233
Blastp_CBE
32.94
36%
-14
- C2 -
-
3DOG
1
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
229
Blastp_CBE
32.89
36%
-12
- C2 -
-
6GVA
3
CDK2_HUMAN
A:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
173
Blastp_CBE
32.83
36%
-21
- C2 -
-
4CFN
1
CDK2_HUMAN
A:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
187
Blastp_CBE
32.81
36%
-24
- C2 -
-
4BCQ
1
CDK2_HUMAN
A:
[7-292]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
-----
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
181
Blastp_CBE
32.81
36%
-17
- C2 -
-
1OGU
1
CDK2_HUMAN
A:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
169
Blastp_CBE
32.78
36%
-21
- C2 -
-
6GUC
1
CDK2_HUMAN
A:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
202
Blastp_CBE
32.71
36%
-20
- C2 -
-
3MY5
3
CDK2_HUMAN
A:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
371
Blastp_CBE
32.67
36%
-17
- C2 -
-
2IW6
1
CDK2_HUMAN
A:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
----
K
T
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
144
Blastp_CBE
32.65
36%
-23
- C2 -
-
4CFU
1
CDK2_HUMAN
C:
[3-294]
---------------------------------------------------------------------------------------------------------------
P
G
S
M
E
-
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
--------------------------------------
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
177
Blastp_CBE
32.56
36%
-19
- C2 -
-
1OIU
1
CDK2_HUMAN
A:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
171
Blastp_CBE
32.52
36%
-20
- C2 -
-
6GUB
1
CDK2_HUMAN
A:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
203
Blastp_CBE
32.47
36%
-27
- C2 -
-
3BHV
1
CDK2_HUMAN
C:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
--------------------------------------
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
207
Blastp_CBE
32.45
36%
-24
- C2 -
-
3BHT
1
CDK2_HUMAN
C:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
--------------------------------------
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
193
Blastp_CBE
32.39
36%
-28
- C2 -
-
4BCO
1
CDK2_HUMAN
C:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
---------------------------------------
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
185
Blastp_CBE
32.29
36%
-18
- C2 -
-
4EOQ
1
CDK2_HUMAN
A:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
191
Blastp_CBE
32.28
36%
-25
- C2 -
-
4BCP
1
CDK2_HUMAN
C:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
--------------------------------------
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
369
Blastp_CBE
32.06
36%
-14
- C2 -
-
2IW9
1
CDK2_HUMAN
A:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
----
K
T
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
224
Blastp_CBE
32.06
36%
-29
- C2 -
-
4EOR
1
CDK2_HUMAN
C:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
------------------------------------
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
175
Blastp_CBE
32.04
36%
-20
- C2 -
-
1OIY
1
CDK2_HUMAN
A:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
205
Blastp_CBE
31.99
36%
-26
- C2 -
-
3BHU
1
CDK2_HUMAN
C:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
--------------------------------------
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
166
Blastp_CBE
31.89
36%
-20
- C2 -
-
6GUF
1
CDK2_HUMAN
A:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
189
Blastp_CBE
31.74
36%
-17
- C2 -
-
4BCM
1
CDK2_HUMAN
A:
[7-292]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
210
Blastp_CBE
31.71
36%
-14
- C2 -
-
4EOS
1
CDK2_HUMAN
A:
[7-292]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---------
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
-
Y
K
P
----
S
---
F
P
K
W
A
R
Q
D
F
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
180
Blastp_CBE
31.65
36%
-23
- C2 -
-
1OGU
1
CDK2_HUMAN
C:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
--------------------------------------
S
K
V
----
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
201
Blastp_CBE
31.25
36%
-30
- C2 -
-
3MY5
1
CDK2_HUMAN
C:
[6-291]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
----------------------------------------------
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
232
Blastp_CBE
31.19
36%
-21
- C2 -
-
3DOG
1
CDK2_HUMAN
C:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
----------------------------------------------
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
234
Blastp_CBE
30.79
36%
-27
- C2 -
-
3DDQ
1
CDK2_HUMAN
C:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
-----------------------------------------------
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
368
Blastp_CBE
30.58
36%
-22
- C2 -
-
2IW9
1
CDK2_HUMAN
C:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
----
K
T
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--------------------------------------------
V
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
212
Blastp_CBE
30.53
36%
-29
- C2 -
-
5LMK
1
?
C:
[5-290]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
-----------------------------------------------
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
139
Blastp_CBE
30.48
36%
-28
- C2 -
-
2IW8
1
CDK2_HUMAN
C:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
H
V
D
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
-----------------------------------------------
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
142
Blastp_CBE
30.45
36%
-27
- C2 -
-
4CFV
1
CDK2_HUMAN
C:
[5-294]
-----------------------------------------------------------------------------------------------------------------
S
M
E
-
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
----------------------------------------------
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
176
Blastp_CBE
30.36
36%
-30
- C2 -
-
1OIU
1
CDK2_HUMAN
C:
[8-293]
----------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
-----------------------------------------------
P
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
154
Blastp_CBE
30.16
36%
-20
- C2 -
-
4CFM
1
CDK2_HUMAN
C:
[5-294]
-----------------------------------------------------------------------------------------------------------------
S
M
E
-
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
T
E
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
V
P
-----
V
R
T
Y
HE-
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
----------------------------------------------
P
LDE
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
--------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------------------------------------------------------------------