@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : IRAK4_HUMAN: (2020-09-11 )
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
Atome Classification :
(412 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190------.......200.-..-------.-..--.-210.......220..----.....230....--...240.......250-.....----...260.......270..-.-.-.----..280----.---.---.......290....------...300..--.-------.---.---.---.310.......-----320.--------......330.......340.....-..350........-.360-.-.----..------.-.-..370.......380--.-.....---.390-------------------.----........400.......410......-.-420.-.....-----..--430.......440.......450.......460
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNKPI
T
P
S
T
Y
V
R
C
L
N
V
G
L
I
R
K
L
S
D
FI
D
P
Q
E
G
W
K
K
L
A
V
A
I
KKPSGDDR
Y
N
Q
F
H
I
R
R
F
E
A
L
L
QTGKS
P
T
S
E
L
L
F
DWGTTNC
T
V
G
D
L
V
D
L
L
I
QNEFFA
P
A
S
L
LLPDAVPKTANTLPSKE
A
I
T
V
QQKQMPFCDKDR
T
L
M
T
P
V
Q
N
L
E
Q
SYMPPDSSSPENK
S
L
E
VSD
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
TNNFDERPISVGGNKM------GEGG
F
G
V
V
Y
K
G-YV-------N-N
T
--
T
-
V
A
V
K
K
L
A
A
M
VDI
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
KCQHE
N
L
V
E
L
LG-F-SSDGD----
D
L
C
L
V
Y
V
YMPNG
S
L
L
D
R
L
-S-C-L----DGT------P---P---L
S
W
H
M
R
C
K
IAQGAA------N
G
I
N
F
LHE--N-------H---
H
---
I
---
H
R
D
IKSA
N
I
L
L-----DEAF--------T
A
K
I
S
DFGL
A
R
A
S
E
K
F
A
Q
T
V
M
T
S
R-IVG--T
T
A
YMA
P
E
-
A
L-R-G-E----IT------P-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
IT--G-LPAVD---EH---------------------R----EP
Q
L
L
L
D
I
K
E
EIE
D
E
E
K
T
I
E
D
Y
I
D
K
KM-N-DA-D-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
KKNKRP
D
I
K
K
V
Q
Q
L
L
Q
E
MTAS
80
Blastp_CBE
89.05
98%
-96
- C1 -
-
6O95
1
IRAK4_HUMAN
D:
[18-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
---
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
532
HHSearch
88.24
100%
-95
- C1 -
-
6MOM
2
?
D:
[7-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
T
V
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
74
Blastp_CBE
88.01
98%
-98
- C1 -
-
6UYA
1
?
B:
[22-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
1
PsiBlast_PDB
87.78
100%
-103
- C1 -
-
6EG9
1
IRAK4_HUMAN
A:
[16-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
---
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
------------------
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
50
Blastp_CBE
87.75
99%
-91
- C1 -
-
6O8U
1
IRAK4_HUMAN
C:
[5-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
T
----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
87
Blastp_CBE
87.71
98%
-96
- C1 -
-
6O94
1
IRAK4_HUMAN
A:
[20-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
68
Blastp_CBE
87.45
98%
-95
- C1 -
-
6MOM
2
?
D:
[7-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
V
M
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
69
Blastp_CBE
87.36
98%
-97
- C1 -
-
6MOM
1
?
C:
[6-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
---
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
S
44
Blastp_CBE
87.27
99%
-95
- C1 -
-
6EGF
1
IRAK4_HUMAN
B:
[6-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
N
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
---------------
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
S
16
PsiBlast_PDB
87.21
99%
-107
- C1 -
-
6O8U
2
IRAK4_HUMAN
A:
[6-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
------
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
------
V
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
49
Blastp_CBE
87.17
99%
-94
- C1 -
-
6O8U
1
IRAK4_HUMAN
D:
[4-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
M
V
-
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
----
Q
T
V
M
--
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
143
Blastp_CBE
86.79
98%
-90
- C1 -
-
6N8G
1
IRAK4_HUMAN
A:
[1-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
----
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
86
Blastp_CBE
86.78
98%
-92
- C1 -
-
6O94
1
IRAK4_HUMAN
B:
[19-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
54
Blastp_CBE
86.77
99%
-96
- C1 -
-
5K7G
1
IRAK4_HUMAN
D:
[5-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
---
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
-----
T
V
M
--
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
6
PsiBlast_PDB
86.73
99%
-96
- C1 -
-
2NRU
1
IRAK4_HUMAN
A:
[11-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
T
V
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
76
Blastp_CBE
86.44
98%
-94
- C1 -
-
6O9D
1
IRAK4_HUMAN
D:
[21-315]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
------
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
--
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
71
Blastp_CBE
86.44
98%
-96
- C1 -
-
6MOM
1
?
A:
[7-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
S
28
Blastp_CBE
86.00
99%
-92
- C1 -
-
2NRU
1
IRAK4_HUMAN
D:
[11-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
T
V
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
51
Blastp_CBE
85.98
99%
-92
- C1 -
-
6O8U
1
IRAK4_HUMAN
B:
[2-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
D
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
------
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
-----
T
V
M
--
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
30
Blastp_CBE
85.97
99%
-93
- C1 -
-
2NRU
1
IRAK4_HUMAN
B:
[10-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
T
V
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
85
Blastp_CBE
85.88
98%
-89
- C1 -
-
6O94
1
IRAK4_HUMAN
C:
[20-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
------
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
22
Blastp_CBE
85.78
100%
-94
- C1 -
-
6EG9
1
IRAK4_HUMAN
B:
[17-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
---
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
-------------------
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
34
Blastp_CBE
85.71
99%
-90
- C1 -
-
5UIT
1
IRAK4_HUMAN
B:
[27-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
138
Blastp_CBE
85.56
99%
-100
- C1 -
-
6F3D
1
IRAK4_HUMAN
B:
[1-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
---
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
-----
T
V
M
--
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
70
Blastp_CBE
85.55
98%
-84
- C1 -
-
6MOM
2
?
B:
[7-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
---
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
21
Blastp_CBE
85.48
100%
-100
- C1 -
-
6EGA
1
IRAK4_HUMAN
B:
[16-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
-------------------
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
59
Blastp_CBE
85.47
99%
-94
- C1 -
-
5K75
1
IRAK4_HUMAN
C:
[5-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
-----
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
----
Q
T
V
M
--
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
29
Blastp_CBE
85.47
99%
-95
- C1 -
-
2NRU
1
IRAK4_HUMAN
C:
[11-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
T
V
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
58
Blastp_CBE
85.41
99%
-93
- C1 -
-
5K75
1
IRAK4_HUMAN
D:
[5-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
--
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
------
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
5
PsiBlast_PDB
85.36
99%
-93
- C1 -
-
2NRY
1
IRAK4_HUMAN
A:
[11-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
---
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
-----
T
V
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
55
Blastp_CBE
85.31
99%
-97
- C1 -
-
5K7G
1
IRAK4_HUMAN
C:
[5-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
---
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
-----
T
V
M
--
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
141
Blastp_CBE
85.22
98%
-94
- C1 -
-
6N8G
1
IRAK4_HUMAN
C:
[1-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
---
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
27
Blastp_CBE
84.91
99%
-97
- C1 -
-
2NRY
1
IRAK4_HUMAN
B:
[11-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
---
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
----
Q
T
V
M
-
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
56
Blastp_CBE
84.81
99%
-99
- C1 -
-
5K7G
1
IRAK4_HUMAN
B:
[6-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
---
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
--
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
---------------
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
57
Blastp_CBE
84.79
99%
-97
- C1 -
-
5K76
1
IRAK4_HUMAN
B:
[5-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
-----
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
-----
T
V
M
--
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
130
Blastp_CBE
84.70
98%
-97
- C1 -
-
2OIC
1
IRAK4_HUMAN
C:
[2-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
--------
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
----------
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
47
Blastp_CBE
84.65
99%
-92
- C1 -
-
6EGD
1
IRAK4_HUMAN
D:
[5-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
N
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
-------------------
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
25
Blastp_CBE
84.60
99%
-92
- C1 -
-
2NRY
1
IRAK4_HUMAN
D:
[11-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
-------------
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
----
T
V
M
-
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
S
78
Blastp_CBE
84.58
98%
-97
- C1 -
-
6O9D
1
IRAK4_HUMAN
B:
[20-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
----
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
-------
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
14
PsiBlast_PDB
84.58
99%
-107
- C1 -
-
5UIR
1
IRAK4_HUMAN
A:
[28-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
----
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
---
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
--------
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
--------
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
---
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
60
Blastp_CBE
84.53
99%
-104
- C1 -
-
5K75
1
IRAK4_HUMAN
B:
[4-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
------
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
------
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
--
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
----
Q
T
V
M
--
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
33
Blastp_CBE
84.28
99%
-93
- C1 -
-
6F3I
1
IRAK4_HUMAN
B:
[26-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
-------
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
-----
T
V
M
--
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
42
Blastp_CBE
84.06
98%
-100
- C1 -
-
5UIQ
1
IRAK4_HUMAN
C:
[27-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
--
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
--
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
132
Blastp_CBE
84.00
98%
-95
- C1 -
-
2OIC
1
IRAK4_HUMAN
A:
[4-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
---------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
---
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
31
Blastp_CBE
83.96
99%
-101
- C1 -
-
6RFJ
1
?
B:
[26-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
--------
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
------
T
V
M
--
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
139
Blastp_CBE
83.89
99%
-95
- C1 -
-
6F3D
1
IRAK4_HUMAN
A:
[1-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
-----
T
V
M
--
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
530
HHSearch
83.87
100%
-89
- C1 -
-
6EGE
1
IRAK4_HUMAN
D:
[7-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-------
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
N
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
T
V
M
T
S
--------
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
---
79
Blastp_CBE
83.81
98%
-90
- C1 -
-
6O9D
1
IRAK4_HUMAN
A:
[19-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
------
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
18
PsiBlast_PDB
83.79
99%
-103
- C1 -
-
5K75
1
IRAK4_HUMAN
A:
[5-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
---
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
------
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
--------
V
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
10
PsiBlast_PDB
83.75
99%
-86
- C1 -
-
5UIT
1
IRAK4_HUMAN
A:
[25-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
------
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
-----
T
V
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
12
PsiBlast_PDB
83.74
99%
-91
- C1 -
-
4RMZ
1
IRAK4_HUMAN
A:
[12-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
----
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
---
A
Q
T
V
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
45
Blastp_CBE
83.69
99%
-88
- C1 -
-
6EGE
1
IRAK4_HUMAN
D:
[5-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-------
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
N
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
T
V
M
T
S
--------
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
---
26
Blastp_CBE
83.48
99%
-93
- C1 -
-
2NRY
1
IRAK4_HUMAN
C:
[11-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
--------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
----
Q
T
V
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
137
Blastp_CBE
83.36
99%
-97
- C1 -
-
6F3G
1
IRAK4_HUMAN
B:
[1-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
-------
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
-------
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
----
Q
T
V
M
--
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
37
Blastp_CBE
83.27
99%
-101
- C1 -
-
5UIS
1
IRAK4_HUMAN
B:
[28-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-------
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
-------
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
-----
V
M
--
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
--
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
17
PsiBlast_PDB
83.26
99%
-96
- C1 -
-
5K72
1
IRAK4_HUMAN
A:
[5-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
-------
V
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
2
PsiBlast_PDB
83.26
100%
-94
- C1 -
-
6EGA
1
IRAK4_HUMAN
A:
[18-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
--
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
------
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
--
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
-------------------
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
38
Blastp_CBE
83.12
98%
-94
- C1 -
-
4RMZ
1
IRAK4_HUMAN
B:
[12-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
----
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
---
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
32
Blastp_CBE
83.02
99%
-97
- C1 -
-
6RFI
1
?
B:
[26-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
-------
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
------
T
V
M
--
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
62
Blastp_CBE
82.99
99%
-100
- C1 -
-
5K72
1
IRAK4_HUMAN
C:
[5-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
-----
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
--------
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
-----
T
V
M
--
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
24
Blastp_CBE
82.98
99%
-101
- C1 -
-
4U97
1
IRAK4_HUMAN
B:
[18-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
-------
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
N
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
------------
V
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
61
Blastp_CBE
82.97
99%
-102
- C1 -
-
5K72
1
IRAK4_HUMAN
D:
[5-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
-----
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
---------
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
-----
T
V
M
--
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
20
PsiBlast_PDB
82.93
99%
-97
- C1 -
-
5K7G
1
IRAK4_HUMAN
A:
[5-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
-------
V
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
131
Blastp_CBE
82.89
98%
-101
- C1 -
-
2OIC
1
IRAK4_HUMAN
B:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
--
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
--------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
---
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
11
PsiBlast_PDB
82.74
99%
-98
- C1 -
-
5UIS
1
IRAK4_HUMAN
A:
[28-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
--
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
---------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
--------
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
---
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
23
Blastp_CBE
82.56
99%
-103
- C1 -
-
4U9A
1
IRAK4_HUMAN
B:
[18-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
-------
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
N
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
------------
V
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
4
PsiBlast_PDB
82.52
99%
-105
- C1 -
-
4U9A
1
IRAK4_HUMAN
A:
[18-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
---------
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
N
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
--------
T
V
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
46
Blastp_CBE
82.51
99%
-102
- C1 -
-
6EGE
1
IRAK4_HUMAN
A:
[7-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
---------
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
N
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
-----------
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
53
Blastp_CBE
82.35
99%
-103
- C1 -
-
5K7I
1
IRAK4_HUMAN
A:
[5-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
--------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
--------
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
-----
T
V
M
--
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
64
Blastp_CBE
81.98
97%
-92
- C1 -
-
5W85
1
IRAK4_HUMAN
B:
[9-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
--
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
--------
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
127
Blastp_CBE
81.70
98%
-104
- C1 -
-
2OID
1
IRAK4_HUMAN
B:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
--
G
N
K
---------
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
---------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
---
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
48
Blastp_CBE
81.50
99%
-100
- C1 -
-
6EGD
1
IRAK4_HUMAN
A:
[7-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
--
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
-------
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
N
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
-------------------
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
36
Blastp_CBE
81.43
99%
-105
- C1 -
-
5UIS
1
IRAK4_HUMAN
C:
[25-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
--
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
------------
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
---------
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
------
V
M
--
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
---
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
19
PsiBlast_PDB
81.41
99%
-108
- C1 -
-
5K76
1
IRAK4_HUMAN
A:
[6-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
--
G
N
K
M
------
G
E
----
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
-------
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
-------
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
------
T
V
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
63
Blastp_CBE
81.38
99%
-95
- C1 -
-
5K72
1
IRAK4_HUMAN
B:
[6-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
---------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
--
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
---------------
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
3
PsiBlast_PDB
81.38
99%
-105
- C1 -
-
4U97
1
IRAK4_HUMAN
A:
[18-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
---------
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
N
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
--------
T
V
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
8
PsiBlast_PDB
81.17
99%
-97
- C1 -
-
6RFI
1
?
A:
[27-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
----
G
N
K
M
------
G
E
G
--
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
--------
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
-----
A
Q
T
V
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
13
PsiBlast_PDB
80.85
99%
-105
- C1 -
-
5UIQ
1
IRAK4_HUMAN
A:
[27-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
------
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
----------
T
--
T
-
V
A
V
K
K
L
A
A
-------------
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
--------
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
----
Q
T
V
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
9
PsiBlast_PDB
80.56
99%
-106
- C1 -
-
6RFJ
1
?
A:
[27-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
-----
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
--------
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
----------
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
-------
V
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
7
PsiBlast_PDB
79.81
99%
-111
- C1 -
-
6F3I
1
IRAK4_HUMAN
A:
[27-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
-----
G
N
K
M
------
G
E
----
V
V
Y
K
G
-
Y
V
----------
T
--
T
-
V
A
V
K
K
L
--------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
----------
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
-------
V
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
52
Blastp_CBE
79.72
99%
-106
- C1 -
-
5K7I
1
IRAK4_HUMAN
B:
[5-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
--
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
-------
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
----------
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
-----
T
V
M
--
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
125
Blastp_CBE
79.34
98%
-100
- C1 -
-
2OID
1
IRAK4_HUMAN
D:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
-
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
-------------------
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
126
Blastp_CBE
76.17
98%
-109
- C1 -
-
2OID
1
IRAK4_HUMAN
C:
[7-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
------
M
------
G
----
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
----------------------
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
---
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
35
Blastp_CBE
76.13
99%
-113
- C1 -
-
5UIS
1
IRAK4_HUMAN
D:
[28-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
--
D
E
R
P
------
K
M
------
G
E
G
--
G
V
V
Y
K
G
-
Y
V
-------------
T
-
V
A
V
K
K
L
------------------
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
----------
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
------
V
M
--
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
--
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
128
Blastp_CBE
75.76
98%
-97
- C1 -
-
2OID
1
IRAK4_HUMAN
A:
[5-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
-------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
----------------------
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
----------
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
75
Blastp_CBE
74.44
98%
-51
- C1 -
-
6UYA
1
?
A:
[20-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
---
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
83
Blastp_CBE
74.24
98%
-44
- C1 -
-
6O95
1
IRAK4_HUMAN
A:
[19-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
--
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
84
Blastp_CBE
73.90
98%
-47
- C1 -
-
6O94
1
IRAK4_HUMAN
D:
[20-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
------
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
15
PsiBlast_PDB
73.79
99%
-43
- C1 -
-
5UIU
1
IRAK4_HUMAN
A:
[28-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
-----
T
V
M
T
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
136
Blastp_CBE
73.68
98%
-44
- C1 -
-
4Y73
1
IRAK4_HUMAN
A:
[5-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
93
Blastp_CBE
73.58
98%
-51
- C1 -
-
5T1S
1
IRAK4_HUMAN
C:
[5-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
------
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
S
135
Blastp_CBE
73.47
98%
-49
- C1 -
-
4Y73
1
IRAK4_HUMAN
B:
[3-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
----
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
102
Blastp_CBE
73.24
98%
-46
- C1 -
-
4ZTN
1
IRAK4_HUMAN
C:
[5-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
------
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
S
133
Blastp_CBE
73.16
98%
-44
- C1 -
-
4Y73
1
IRAK4_HUMAN
D:
[6-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
96
Blastp_CBE
73.10
98%
-40
- C1 -
-
5KX8
1
IRAK4_HUMAN
D:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
91
Blastp_CBE
73.09
98%
-47
- C1 -
-
5T1T
1
IRAK4_HUMAN
A:
[4-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
---
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
72
Blastp_CBE
73.08
98%
-44
- C1 -
-
6UYA
1
?
D:
[19-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
---
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
81
Blastp_CBE
73.03
98%
-46
- C1 -
-
6O95
1
IRAK4_HUMAN
C:
[22-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
-------
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
88
Blastp_CBE
72.95
98%
-42
- C1 -
-
5T1T
1
IRAK4_HUMAN
D:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
142
Blastp_CBE
72.89
98%
-39
- C1 -
-
6N8G
1
IRAK4_HUMAN
B:
[1-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
39
Blastp_CBE
72.77
98%
-44
- C1 -
-
5UIU
1
IRAK4_HUMAN
B:
[27-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
89
Blastp_CBE
72.64
98%
-46
- C1 -
-
5T1T
1
IRAK4_HUMAN
C:
[5-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
S
134
Blastp_CBE
72.63
98%
-49
- C1 -
-
4Y73
1
IRAK4_HUMAN
C:
[6-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
S
82
Blastp_CBE
72.61
98%
-51
- C1 -
-
6O95
1
IRAK4_HUMAN
B:
[20-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
-----
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
--
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
104
Blastp_CBE
72.53
98%
-43
- C1 -
-
4ZTN
1
IRAK4_HUMAN
A:
[4-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
118
Blastp_CBE
72.50
98%
-47
- C1 -
-
4YO6
1
IRAK4_HUMAN
C:
[5-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
S
99
Blastp_CBE
72.12
98%
-42
- C1 -
-
5KX8
1
IRAK4_HUMAN
A:
[4-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
65
Blastp_CBE
72.02
97%
-37
- C1 -
-
5W85
1
IRAK4_HUMAN
A:
[9-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
-
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
--------
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
95
Blastp_CBE
71.96
98%
-48
- C1 -
-
5T1S
1
IRAK4_HUMAN
A:
[4-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
-----
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
------
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
108
Blastp_CBE
71.85
98%
-39
- C1 -
-
4ZTM
1
IRAK4_HUMAN
A:
[3-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
114
Blastp_CBE
71.80
98%
-44
- C1 -
-
4YP8
2
IRAK4_HUMAN
C:
[5-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
S
77
Blastp_CBE
71.79
98%
-44
- C1 -
-
6O9D
1
IRAK4_HUMAN
C:
[20-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
------
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
--
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
117
Blastp_CBE
71.69
98%
-42
- C1 -
-
4YO6
2
IRAK4_HUMAN
D:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
----
I
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
120
Blastp_CBE
71.55
98%
-39
- C1 -
-
4YO6
1
IRAK4_HUMAN
A:
[4-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
97
Blastp_CBE
71.36
98%
-40
- C1 -
-
5KX8
1
IRAK4_HUMAN
C:
[5-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
S
100
Blastp_CBE
71.30
98%
-38
- C1 -
-
5KX7
1
IRAK4_HUMAN
B:
[4-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
144
Blastp_CBE
71.28
99%
-42
- C1 -
-
6F3E
1
IRAK4_HUMAN
B:
[1-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
------
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
---
A
Q
V
M
--
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
109
Blastp_CBE
71.06
98%
-43
- C1 -
-
4ZTL
1
IRAK4_HUMAN
D:
[5-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
-
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
S
105
Blastp_CBE
70.97
98%
-40
- C1 -
-
4ZTM
1
IRAK4_HUMAN
D:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
-
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
112
Blastp_CBE
70.93
98%
-44
- C1 -
-
4ZTL
1
IRAK4_HUMAN
A:
[6-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
----
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
121
Blastp_CBE
70.83
98%
-47
- C1 -
-
4XS2
1
IRAK4_HUMAN
D:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
---
G
N
K
M
------
G
E
G
--
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
------
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
124
Blastp_CBE
70.82
98%
-47
- C1 -
-
4XS2
1
IRAK4_HUMAN
A:
[4-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
---
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
92
Blastp_CBE
70.79
98%
-44
- C1 -
-
5T1S
1
IRAK4_HUMAN
D:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
------------
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
110
Blastp_CBE
70.77
98%
-47
- C1 -
-
4ZTL
1
IRAK4_HUMAN
C:
[5-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
------
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
-------
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
S
129
Blastp_CBE
70.39
98%
-48
- C1 -
-
2OIC
1
IRAK4_HUMAN
D:
[2-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
--------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
S
106
Blastp_CBE
70.32
98%
-53
- C1 -
-
4ZTM
1
IRAK4_HUMAN
C:
[5-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
------
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
-------
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
S
101
Blastp_CBE
70.30
98%
-35
- C1 -
-
4ZTN
1
IRAK4_HUMAN
D:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
116
Blastp_CBE
70.26
98%
-40
- C1 -
-
4YP8
1
IRAK4_HUMAN
A:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
------
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
94
Blastp_CBE
70.24
98%
-53
- C1 -
-
5T1S
1
IRAK4_HUMAN
B:
[2-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
--------------
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
---
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
67
Blastp_CBE
70.20
97%
-43
- C1 -
-
5W84
1
IRAK4_HUMAN
A:
[10-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
-----
I
T
T
-------
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
90
Blastp_CBE
70.11
98%
-44
- C1 -
-
5T1T
1
IRAK4_HUMAN
B:
[2-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
---------------
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
---
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
107
Blastp_CBE
69.94
98%
-47
- C1 -
-
4ZTM
1
IRAK4_HUMAN
B:
[2-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
--------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
----
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
140
Blastp_CBE
69.92
98%
-38
- C1 -
-
6N8G
1
IRAK4_HUMAN
D:
[1-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
---------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
123
Blastp_CBE
69.90
98%
-48
- C1 -
-
4XS2
1
IRAK4_HUMAN
B:
[2-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
---
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
----
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
113
Blastp_CBE
69.36
98%
-39
- C1 -
-
4YP8
1
IRAK4_HUMAN
D:
[5-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
A
----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
41
Blastp_CBE
69.26
98%
-51
- C1 -
-
5UIQ
1
IRAK4_HUMAN
D:
[27-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
--------
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
--
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
---
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
--
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
103
Blastp_CBE
69.12
98%
-44
- C1 -
-
4ZTN
1
IRAK4_HUMAN
B:
[2-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
---------------
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
43
Blastp_CBE
69.02
98%
-43
- C1 -
-
5UIQ
1
IRAK4_HUMAN
B:
[27-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
---
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
----------
T
--
T
-
V
A
V
K
K
L
A
A
------
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
--
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
--
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
40
Blastp_CBE
68.96
98%
-45
- C1 -
-
5UIR
1
IRAK4_HUMAN
B:
[27-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
---
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
----------
T
--
T
-
V
A
V
K
K
L
A
A
------
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
--
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
-
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
146
Blastp_CBE
68.65
98%
-48
- C1 -
-
6F3G
1
IRAK4_HUMAN
A:
[1-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
--
N
K
M
------
G
E
---
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-----
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
--
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
---
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
73
Blastp_CBE
68.65
98%
-42
- C1 -
-
6UYA
1
?
C:
[19-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
---------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
--
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
---
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
122
Blastp_CBE
68.63
98%
-50
- C1 -
-
4XS2
1
IRAK4_HUMAN
C:
[5-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
------
T
T
E
----
E
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
--------
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
S
119
Blastp_CBE
68.19
98%
-41
- C1 -
-
4YO6
2
IRAK4_HUMAN
B:
[2-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
-----------------
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
----
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
115
Blastp_CBE
68.02
98%
-39
- C1 -
-
4YP8
1
IRAK4_HUMAN
B:
[2-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
----------------
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
----
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
145
Blastp_CBE
67.83
99%
-51
- C1 -
-
6F3E
1
IRAK4_HUMAN
A:
[1-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
--------------
L
K
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
---------
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
------
V
M
--
S
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
--
98
Blastp_CBE
67.65
98%
-46
- C1 -
-
5KX8
1
IRAK4_HUMAN
B:
[2-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
T
R
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
----------------
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
----
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
111
Blastp_CBE
65.65
98%
-49
- C1 -
-
4ZTL
1
IRAK4_HUMAN
B:
[6-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
--
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
K
L
A
--------------------
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
S
D
G
D
----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
----
A
Q
V
M
---
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
66
Blastp_CBE
63.83
97%
-45
- C1 -
-
5W84
1
IRAK4_HUMAN
B:
[13-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
P
I
S
V
G
G
N
K
M
------
G
E
G
G
F
G
V
V
Y
K
G
-
Y
V
-------
N
-
N
T
--
T
-
V
A
V
K
---------------------
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
-
F
-
S
----------
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-
S
-
C
-
L
----
D
G
T
------
P
---
P
---
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
------
N
G
I
N
F
L
H
E
--
N
-------
H
---
H
---
I
---
H
R
D
I
K
S
A
N
I
L
L
-----
D
E
A
F
--------
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
-----
R
-
I
V
G
--
T
T
A
Y
M
A
P
E
-
A
L
-
R
-
G
-
E
----
I
T
------
P
-
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
--
G
-
L
P
A
V
D
---
E
H
---------------------
R
----
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
-
N
-
D
A
-
D
-
S
T
S
V
E
-----
A
M
--
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
A
-
156
Blastp_CBE
58.61
39%
6
- C1 -
-
6CTH
1
?
A:
[5-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
L
N
E
L
A
K
V
T
S
N
F
N
A
E
------
N
K
L
------
G
E
G
G
F
G
S
V
Y
R
G
-
F
L
RD-----
S
-
D
T
--
Y
-
I
A
V
K
K
----
V
S
R
A
S
K
----
Q
G
I
K
E
Y
A
S
E
V
K
I
--
I
S
R
L
R
H
K
N
L
V
K
L
I
G
-
W
-
C
H
E
R
G
----
E
L
M
L
V
Y
E
F
M
A
N
G
S
L
D
S
H
I
-----
F
----
K
G
K
------
S
---
L
---
L
T
W
E
V
R
Y
R
I
V
K
D
L
A
------
S
A
L
L
Y
L
H
E
EG
D
-------
H
---
C
---
V
L--
H
R
D
I
K
T
S
N
I
M
L
-----
D
S
S
F
--------
N
A
K
L
G
D
F
G
L
A
R
L
V
D
-------
K
T
L
-
L
A
G
--
T
V
G
Y
M
A
P
E
-
C
L
S
S
-
G
-
K
----
A
S
------
K
-
E
-
S
D
V
Y
S
F
G
V
V
A
L
E
I
A
S
--
G
-
R
R
S
I
E
PKF
E
E
---------------------
S
----
E
A
L
L
L
V
P
W
V
W
E
S
Y
G
N
E
R
-
I
L
D
I
A
D
R
K
L
-
G
-
M
A
F
D
-
P
K
Q
L
E
-----
C
L
--
V
M
V
G
L
W
C
A
H
P
S
H
N
L
R
P
S
I
R
Q
V
I
Q
V
L
N
-----
158
Blastp_CBE
57.29
35%
-30
- C1 -
-
6BFN
1
IRAK1_HUMAN
A:
[16-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
S
R
G
T
H
N
F
S
E
E
------
L
K
I
------
G
E
G
G
F
G
C
V
Y
R
A
-
V
M
-------
R
-
N
T
--
V
-
Y
A
V
K
R
L
K
-----
E
W
T
----
A
V
K
Q
S
F
L
T
E
V
E
Q
--
L
S
R
F
R
H
P
N
I
V
D
F
A
G
-
Y
-
C
A
Q
N
G
----
F
Y
C
L
V
Y
G
F
L
P
N
G
S
L
E
D
R
L
-
H
-
C
Q
T
----
Q
A
C
------
P
---
P
---
L
S
W
P
Q
R
L
D
I
L
L
G
T
A
------
R
A
I
Q
F
L
H
Q
--
D
-------
S
---
P
SL-
I
---
H
G
D
I
K
S
S
N
V
L
L
-----
D
E
R
L
--------
T
P
K
L
G
D
F
G
L
A
R
F
S
-
R
---------T
V
R
G
--
T
L
A
Y
L
P
E
E
-
Y
I
-
K
T
G
-
R
----
L
A
------
V
-
D
-
T
D
T
F
S
F
G
V
V
V
L
E
T
L
A
--
G
-
Q
R
A
V
K
---
T
H
GARTKYLKDLVEEEAEEAGVA---------------
A
A
D
A
W
A
A
P
I
A
M
Q
I
Y
K
K
H
-
L
-
D
P
-
R
-
P
G
P
C
P
PELGL
G
L
--
G
Q
L
A
C
C
C
L
H
R
R
A
K
R
R
P
P
M
T
Q
V
Y
E
R
L
E
K
L
Q
A
-
159
Blastp_CBE
53.96
36%
-14
- C1 -
-
5XD6
1
CARK1_ARATH
B:
[16-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
R
D
I
T
D
N
Y
G
S
K
S
L
------
I
------
G
E
G
S
Y
G
R
V
F
Y
G
-
I
L
K------
S
-
G
K
--
A
-
A
A
I
K
K
L
D
-----
S
S
K
----
Q
P
D
Q
E
F
L
A
Q
V
S
M
--
V
S
R
L
R
Q
E
N
V
V
A
L
L
G
-
Y
-
C
V
D
G
P
----
L
R
V
L
A
Y
E
Y
A
P
N
G
S
L
H
D
I
L
-
H
-
G
-
R
----
K
G
V
KGAQPG
P
---
V
---
L
S
W
H
Q
R
V
K
I
A
V
G
A
A
------
R
G
L
E
Y
L
H
E
--
K
ANP----
H
---
V
---
I
---
H
R
D
I
K
S
S
N
V
L
L
-----
F
D
D
D
--------
V
A
K
I
A
D
F
D
L
S
----------------------
G
Y
H
A
P
E
Y
A
M
-
T
-
G
-
T
----
L
S
------
T
-
K
-
S
D
V
Y
S
F
G
V
V
L
L
E
L
L
T
--
G
-
R
K
P
V
D
---
H
T
LP-------------------
R
----
G
Q
Q
S
V
V
T
W
A
T
P
K
L
S
E
D
K
-
V
K
Q
C
V
D
A
R
L
-
N
G
E
Y
-
P
-
P
K
A
V
A
-----
K
L
--
A
A
V
A
A
L
C
V
Q
Y
E
A
D
F
R
P
N
M
S
I
V
V
K
A
L
Q
P
L
---
157
Blastp_CBE
53.79
35%
-24
- C1 -
-
6BFN
1
IRAK1_HUMAN
B:
[16-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
S
R
G
T
H
N
F
S
E
E
------
L
K
I
------
G
E
G
G
F
G
C
V
Y
R
A
-
V
M
-------
R
-
N
T
--
V
-
Y
A
V
K
R
L
K
-----
E
W
T
----
A
V
K
Q
S
F
L
T
E
V
E
Q
--
L
S
R
F
R
H
P
N
I
V
D
F
A
G
-
Y
-
C
A
Q
N
G
----
F
Y
C
L
V
Y
G
F
L
P
N
G
S
L
E
D
R
L
-
H
-
C
Q-------
C
------
P
---
P
---
L
S
W
P
Q
R
L
D
I
L
L
G
T
A
------
R
A
I
Q
F
L
H
Q
--
D
-------
S
---
P
SL-
I
---
H
G
D
I
K
S
S
N
V
L
L
-----
D
E
R
L
--------
T
P
K
L
G
D
F
G
L
A
R
F
S
-
R
---------T
V
R
G
--
T
L
A
Y
L
P
E
E
-
Y
I
-
K
T
G
-
R
----
L
A
------
V
-
D
-
T
D
T
F
S
F
G
V
V
V
L
E
T
L
A
--
G
-
Q
R
A
V
K
---
T
H
GARTKYLKDLVEEEAEEAGVA------------------
A
W
A
A
P
I
A
M
Q
I
Y
K
K
H
-
L
-
D
P
-
R
-
P
G
P
C
P
PELGL
G
L
--
G
Q
L
A
C
C
C
L
H
R
R
A
K
R
R
P
P
M
T
Q
V
Y
E
R
L
E
K
L
Q
A
-
207
Blastp_CBE
50.33
31%
-61
- C1 -
-
4PP7
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
------
G
S
G
S
F
G
T
V
Y
K
G
-
K
W
-------
H
-
G
D
----
V
A
V
K
M
L
N
--
V
T
A
P
T
P
----
Q
Q
L
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
K
-
P
----
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
-
I
----
E
T
K
------
F
---
E
---
M
I
--
K
L
I
D
I
A
R
Q
T
A
------
Q
G
M
D
Y
L
H
A
--
K
-------
S
---
I
---
I
---
H
R
D
L
K
S
N
N
I
F
L
-----
H
E
D
L
--------
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
-
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
-
R
-
M
-
Q
DKNP
Y
S
------
F
-
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
---
I
N
---------------------
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
-
K
V
-
R
-
S
N
C
P
K
-----
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
---------------
211
Blastp_CBE
49.96
31%
-61
- C1 -
-
4EHE
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
------
G
S
G
S
F
G
T
V
Y
K
G
-
K
W
-------
H
-
G
D
----
V
A
V
K
M
L
N
--
V
T
A
P
T
P
----
Q
Q
L
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
K
-
P
----
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
-
I
----
E
T
K
------
F
---
E
---
M
I
--
K
L
I
D
I
A
R
Q
T
A
------
Q
G
M
D
Y
L
H
A
--
K
-------
S
---
I
---
I
---
H
R
D
L
K
S
N
N
I
F
L
-----
H
E
D
L
--------
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
-
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
-
R
-
M
-
Q
DKNP
Y
S
------
F
-
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
---
I
N
---------------------
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
-
K
V
-
R
-
S
N
C
P
K
-----
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
---------------
202
Blastp_CBE
49.70
31%
-62
- C1 -
-
4MBJ
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
------
G
S
G
S
F
G
T
V
Y
K
G
-
K
W
-------
H
-
G
D
----
V
A
V
K
M
L
N
--
V
T
A
P
T
P
----
Q
Q
L
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
K
-
P
----
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
-
I
----
E
T
K
------
F
---
E
---
M
I
--
K
L
I
D
I
A
R
Q
T
A
------
Q
G
M
D
Y
L
H
A
--
K
-------
S
---
I
---
I
---
H
R
D
L
K
S
N
N
I
F
L
-----
H
E
D
L
--------
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
-
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
-
R
-
M
-
Q
DKNP
Y
S
------
F
-
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
---
I
N
---------------------
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
-
K
V
-
R
-
S
N
C
P
K
-----
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
---------------
181
Blastp_CBE
49.50
31%
-72
- C1 -
-
5VAL
1
B:
[18-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
------
G
S
G
S
F
G
T
V
Y
K
G
-
K
W
-------
H
-
G
D
----
V
A
V
K
M
L
N
--
V
T
A
P
T
P
----
Q
Q
L
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
K
-
P
----
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
-
I
----
E
T
K
------
F
---
E
---
M
I
--
K
L
I
D
I
A
R
Q
T
A
------
Q
G
M
D
Y
L
H
A
--
K
-------
S
---
I
---
I
---
H
R
D
L
K
S
N
N
I
F
L
-----
H
E
D
L
--------
T
V
K
I
G
D
F
G
L
------------------
G
--
S
I
L
W
M
A
P
E
-
V
I
-
R
-
M
--NP--
Y
S
------
F
-
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
---
I
N
---------------------
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
-
K
V
-
R
-
S
N
C
P
K
-----
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
---------------
162
Blastp_CBE
49.47
35%
-28
- C1 -
-
5LPY
1
A:
[7-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
F
A
D
L
L
Q
A
T
N
G
F
H
N
D
S
L
------
I
------
G
S
G
G
F
G
D
V
Y
K
A
-
I
L
K------
D
-
G
S
--
A
-
V
A
I
K
K
L
I
H
V
----
S
G
----
Q
G
D
R
E
F
M
A
E
M
E
T
--
I
G
K
I
K
H
R
N
L
V
P
L
L
G
-
Y
-
C
K
V
G
D
----
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
-
H
D
P
-
K
----
K
A
G
------
V
---
K
---
L
N
W
S
T
R
R
K
I
A
I
G
S
A
------
R
G
L
A
F
L
H
H
--
N
CSP----
H
---
I
---
I
---
H
R
D
M
K
S
S
N
V
L
L
-----
D
E
N
L
--------
E
A
R
V
S
D
F
G
M
A
R
L
M
S
A
M
D
H
L
V
T
----
L
A
G
--
T
P
G
Y
V
P
P
E
-
Y
Y
-
Q
-
F
-
R
----
C
S
------
T
-
K
-
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
--
G
-
K
R
P
T
D
SP-
D
---------------------------------
W
V
K
Q
H
---
A
K
L
R
I
S
D
V
F
D
P
E
L
-
M
-
K
E
-
D
P
A
L
E
I
E
-----
L
L
QH
L
K
V
A
V
A
C
L
D
D
R
A
W
R
R
P
T
M
V
Q
V
M
A
M
F
K
E
I
Q
A
-
160
Blastp_CBE
49.23
36%
11
- C1 -
-
5XD6
1
CARK1_ARATH
A:
[16-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
R
D
I
T
D
N
Y
G
S
K
S
L
------
I
------
G
E
G
S
Y
G
R
V
F
Y
G
-
I
L
K------
S
-
G
K
--
A
-
A
A
I
K
K
L
D
-----
S
S
K
----
Q
P
D
Q
E
F
L
A
Q
V
S
M
--
V
S
R
L
R
Q
E
N
V
V
A
L
L
G
-
Y
-
C
V
D
G
P
----
L
R
V
L
A
Y
E
Y
A
P
N
G
S
L
H
D
I
L
-
H
-
G
-
R
-------AQPG--
P
---
V
---
L
S
W
H
Q
R
V
K
I
A
V
G
A
A
------
R
G
L
E
Y
L
H
E
--
K
ANP----
H
---
V
---
I
---
H
R
D
I
K
S
S
N
V
L
L
-----
F
D
D
D
--------
V
A
K
I
A
D
F
D
L
S
N
Q
--------------------
G
Y
H
A
P
E
Y
A
M
-
T
-
G
------
L
S
------
T
-
K
-
S
D
V
Y
S
F
G
V
V
L
L
E
L
L
T
--
G
-
R
K
P
V
D
---
H
T
LP-------------------
R
----
G
Q
Q
S
V
V
T
W
A
T
P
K
L
S
E
D
K
-
V
K
Q
C
V
D
A
R
L
-
N
G
E
Y
-
P
-
P
K
A
V
A
-----
K
L
--
A
A
V
A
A
L
C
V
Q
Y
E
A
D
F
R
P
N
M
S
I
V
V
K
A
L
Q
P
L
---
254
Blastp_CBE
48.79
31%
-68
- C1 -
-
5HIE
1
BRAF_HUMAN
A:
[41-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
------
G
S
G
S
F
G
T
V
Y
K
G
-
K
W
-------
H
-
G
D
----
V
A
V
K
M
L
------
T
P
Q
----
Q
L
-
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
K
-
P
----
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
-
I
----
E
T
K
------
F
---
E
---
M
I
--
K
L
I
D
I
A
R
Q
T
A
------
Q
G
M
D
Y
L
H
A
--
K
-------
S
---
I
---
I
---
H
R
D
L
K
S
N
N
I
F
L
-----
H
E
D
L
--------
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
------------
G
--
S
I
L
W
M
A
P
E
-
V
I
-
R
-
M
-
Q
DKNP
Y
S
------
F
-
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
---
I
N
---------------------
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
-
K
V
-
R
-
S
N
C
P
K
-----
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
---------------
167
Blastp_CBE
48.76
35%
-14
- C1 -
-
5LPZ
1
A:
[7-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
F
A
D
L
L
Q
A
T
N
G
F
H
N
D
S
L
------
I
------
G
S
G
G
F
G
D
V
Y
K
A
-
I
L
K------
D
-
G
S
--
A
-
V
A
I
K
K
L
I
H
V
----
S
G
----
Q
G
D
R
E
F
M
A
E
M
E
T
--
I
G
K
I
K
H
R
N
L
V
P
L
L
G
-
Y
-
C
K
V
G
D
----
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
H
D
-
P
-
K
----
K
A
G
------
V
---
K
---
L
N
W
S
T
R
R
K
I
A
I
G
S
A
------
R
G
L
A
F
L
H
H
--
N
CSP----
H
---
I
---
I
---
H
R
D
M
K
S
S
N
V
L
L
-----
D
E
N
L
--------
E
A
R
V
S
D
F
G
M
A
R
L
M
S
A
M
D
H
L
V
T
----
L
A
G
--
T
P
G
Y
V
P
P
E
-
Y
Y
-
Q
-
S
F
R
----
C
S
------
T
-
K
-
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
--
G
-
K
R
P
T
D
SP----------------------------------
G
W
V
K
Q
H
---
A
K
L
R
I
S
D
V
F
D
P
E
L
-
M
-
K
E
-
D
P
A
L
E
I
E
-----
L
-QH
L
K
V
A
V
A
C
L
D
D
R
A
W
R
R
P
T
M
V
Q
V
M
A
M
F
K
E
I
Q
A
G
163
Blastp_CBE
48.59
35%
-26
- C1 -
-
5LPB
1
A:
[7-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
F
A
D
L
L
Q
A
T
N
G
F
H
N
D
S
L
------
I
------
G
S
G
G
F
G
D
V
Y
K
A
-
I
L
K------
D
-
G
S
--
A
-
V
A
I
K
K
L
I
H
V
----
S
G
----
Q
G
D
R
E
F
M
A
E
M
E
T
--
I
G
K
I
K
H
R
N
L
V
P
L
L
G
-
Y
-
C
K
V
G
D
----
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
-
H
D
P
--------
G
------
V
---
K
---
L
N
W
S
T
R
R
K
I
A
I
G
S
A
------
R
G
L
A
F
L
H
H
--
N
CSP----
H
---
I
---
I
---
H
R
D
M
K
S
S
N
V
L
L
-----
D
E
N
L
--------
E
A
R
V
S
D
F
G
M
A
R
L
M
S
A
M
D
H
L
V
T
----
L
A
G
--
T
P
G
Y
V
P
P
E
-
Y
Y
-
Q
-
F
-
R
----
C
S
------
T
-
K
-
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
--
G
-
K
R
P
T
D
SP-
D
F
--------------------------------
W
V
K
Q
H
---
A
K
L
R
I
S
D
V
F
D
P
E
L
-
M
-
K
E
-
D
P
A
L
E
I
E
-----
L
L
QH
L
K
V
A
V
A
C
L
D
D
R
A
W
R
R
P
T
M
V
Q
V
M
A
M
F
K
E
I
Q
A
-
213
Blastp_CBE
48.55
31%
-65
- C1 -
-
4E4X
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
------
G
S
G
S
F
G
T
V
Y
K
G
-
K
W
-------
H
-
G
D
----
V
A
V
K
M
L
N
--
V
T
A
P
T
P
----
Q
Q
L
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
K
-
P
----
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
-
I
----
E
T
K
------
F
---
E
---
M
I
--
K
L
I
D
I
A
R
Q
T
A
------
Q
G
M
D
Y
L
H
A
--
K
-------
S
---
I
---
I
---
H
R
D
L
K
S
N
N
I
F
L
-----
H
E
D
L
--------
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
-
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
-
R
-
M
-
Q
DKNP
Y
S
------
F
-
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
---
I
N
---------------------
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
-
K
V
-
R
-
S
N
C
P
K
-----
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
---------------
318
Blastp_CBE
48.39
32%
-5
- C1 -
-
3U4W
3
SRC_CHICK
A:
[14-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
R
Q
G
A
-
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
187
Blastp_CBE
48.11
31%
-56
- C1 -
-
3Q96
1
B:
[15-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
------
G
S
G
S
F
G
T
V
Y
K
G
-
K
W
-------
H
-
G
D
----
V
A
V
K
M
L
N
--
V
T
A
P
T
P
----
Q
Q
L
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
K
-
P
----
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
-
I
----
E
T
K
------
F
---
E
---
M
I
--
K
L
I
D
I
A
R
Q
T
A
------
Q
G
M
D
Y
L
H
A
--
K
-------
S
---
I
---
I
---
H
R
D
L
K
S
N
N
I
F
L
-----
H
E
D
L
--------
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
-----------
G
--
S
I
L
W
M
A
P
E
-
V
I
-
R
-
M
-
Q
DKNP
Y
S
------
F
-
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
---
I
N
---------------------
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
-
K
V
-
R
-
S
N
C
P
K
-----
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
---------------
165
Blastp_CBE
48.11
35%
-22
- C1 -
-
4OH4
1
BRI1_ARATH
A:
[32-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
F
A
D
L
L
Q
A
T
N
G
F
H
N
D
S
L
------
I
------
G
S
G
G
F
G
D
V
Y
K
A
-
I
L
K------
D
-
G
S
--
A
-
V
A
I
K
K
L
I
H
V
----
S
G
----
Q
G
D
R
E
F
M
A
E
M
E
T
--
I
G
K
I
K
H
R
N
L
V
P
L
L
G
-
Y
-
C
K
V
G
D
----
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
-
H
D--------------------
K
---
L
N
W
S
T
R
R
K
I
A
I
G
S
A
------
R
G
L
A
F
L
H
H
--
N
CSP----
H
---
I
---
I
---
H
R
D
M
K
S
S
N
V
L
L
-----
D
E
N
L
--------
E
A
R
V
S
D
F
G
M
A
R
L
M
S
A
M
D
H
L
V
T
----
L
A
G
--
T
P
G
Y
V
P
P
E
-
Y
Y
-
Q
-
F
-
R
----
C
S
------
T
-
K
-
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
--
G
-
K
R
P
T
D
SP-
D
F
---------------------
G
----
D
N
N
L
V
G
W
V
K
Q
H
---
A
K
L
R
I
S
D
V
F
D
P
E
L
-
M
-
K
E
-
D
P
A
L
E
I
E
-----
L
L
QH
L
K
V
A
V
A
C
L
D
D
R
A
W
R
R
P
T
M
V
Q
V
M
A
M
F
K
E
I
Q
A
G
243
Blastp_CBE
48.10
31%
-74
- C1 -
-
5C9C
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
------
G
S
G
S
F
G
T
V
Y
K
G
-
K
W
-------
H
-
G
D
----
V
A
V
K
M
L
N
--
V
T
A
P
T
P
----
Q
Q
L
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
K
-
P
----
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
-
I
----
E
T
K
------
F
---
E
---
M
I
--
K
L
I
D
I
A
R
Q
T
A
------
Q
G
M
D
Y
L
H
A
--
K
-------
S
---
I
---
I
---
H
R
D
L
K
S
N
N
I
F
L
-----
H
E
D
L
--------
T
V
K
I
G
D
F
G
L
---------------------
S
I
L
W
M
A
P
E
-
V
I
-
R
-
M
--NP--
Y
S
------
F
-
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
---
I
N
---------------------
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
-
K
V
-
R
-
S
N
C
P
K
-----
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
---------------
249
Blastp_CBE
48.02
31%
-67
- C1 -
-
4MNF
1
B:
[53-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
------
G
S
G
S
F
G
T
V
Y
K
G
-
K
W
-------
H
-
G
D
----
V
A
V
K
M
L
N
--
V
T
A
P
T
P
----
Q
Q
L
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
K
-
P
----
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
-
I
----
E
T
K
------
F
---
E
---
M
I
--
K
L
I
D
I
A
R
Q
T
A
------
Q
G
M
D
Y
L
H
A
--
K
-------
S
---
I
---
I
---
H
R
D
L
K
S
N
N
I
F
L
-----
H
E
D
L
--------
T
V
K
I
G
D
F
G
L
A
T
E
------------------
S
I
L
W
M
A
P
E
-
V
I
-
R
-
M
-
Q
DKNP
Y
S
------
F
-
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
---
I
N
---------------------
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
-
K
V
-
R
-
S
N
C
P
K
-----
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
---------------
214
Blastp_CBE
47.94
31%
-71
- C1 -
-
4E4X
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
------
G
S
G
S
F
G
T
V
Y
K
G
-
K
W
-------
H
-
G
D
----
V
A
V
K
M
L
N
--
V
T
A
P
T
P
----
Q
Q
L
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
K
-
P
----
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
-
I
----
E
T
K
------
F
---
E
---
M
I
--
K
L
I
D
I
A
R
Q
T
A
------
Q
G
M
D
Y
L
H
A
--
K
-------
S
---
I
---
I
---
H
R
D
L
K
S
N
N
I
F
L
-----
H
E
D
L
--------
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
--------
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
-
R
-
M
-
Q
DKNP
Y
S
------
F
-
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
---
I
N
---------------------
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
-
K
V
-
R
-
S
N
C
P
K
-----
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
---------------
201
Blastp_CBE
47.76
31%
-67
- C1 -
-
5FD2
1
BRAF_HUMAN
A:
[34-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
------
G
S
G
S
F
G
T
V
Y
K
G
-
K
W
-------
H
-
G
D
----
V
A
V
K
M
L
N
--
V
T
A
P
T
P
----
Q
Q
L
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
K
-
P
----
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
-
I
----
E
T
K
------
F
---
E
---
M
I
--
K
L
I
D
I
A
R
Q
T
A
------
Q
G
M
D
Y
L
H
A
--
K
-------
S
---
I
---
I
---
H
R
D
L
K
S
N
N
I
F
L
-----
H
E
D
L
--------
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
----------
S
G
--
S
I
L
W
M
A
P
E
-
V
I
-
R
-
M
-
Q
DKNP
Y
S
------
F
-
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
---
I
N
---------------------
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
-
K
V
-
R
-
S
N
C
P
K
-----
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
---------------
193
Blastp_CBE
47.23
31%
-59
- C1 -
-
4FC0
1
B:
[18-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
------
G
S
G
S
F
G
T
V
Y
K
G
-
K
W
-------
H
-
G
D
----
V
A
V
K
M
L
N
--
V
T
A
P
T
P
----
Q
Q
L
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
K
-
P
----
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
-
I
----
E
T
K
------
F
---
E
---
M
I
--
K
L
I
D
I
A
R
Q
T
A
------
Q
G
M
D
Y
L
H
A
--
K
-------
S
---
I
---
I
---
H
R
D
L
K
S
N
N
I
F
L
-----
H
E
D
L
--------
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
-----------
G
--
S
I
L
W
M
A
P
E
-
V
I
-
R
-
M
-
Q
DKNP
Y
S
------
F
-
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
---
I
N
---------------------
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
-
K
V
-
R
-
S
N
C
P
K
-----
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
---------------
445
Blastp_CBE
47.20
32%
-22
- C1 -
-
6F3F
1
SRC_MOUSE
A:
[194-444]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
---------
M
S
P
E
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
T
G
K
YLRL--
P
---
Q
---
L
V
-
D
M
S
A
Q
I
A
S
G
M
A
----------
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
R
Q
G
A
-
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
244
Blastp_CBE
47.19
31%
-64
- C1 -
-
5C9C
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
------
G
S
G
S
F
G
T
V
Y
K
G
-
K
W
-------
H
-
G
D
----
V
A
V
K
M
L
N
----
A
P
T
P
----
Q
Q
L
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
K
-
P
----
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
-
I
----
E
T
K
------
F
---
E
---
M
I
--
K
L
I
D
I
A
R
Q
T
A
------
Q
G
M
D
Y
L
H
A
--
K
-------
S
---
I
---
I
---
H
R
D
L
K
S
N
N
I
F
L
-----
H
E
D
L
--------
T
V
K
I
G
D
F
G
L
A
T
-------------------
S
I
L
W
M
A
P
E
-
V
I
-
R
-
M
-
Q
DKNP
Y
S
------
F
-
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
---
I
N
---------------------
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
-
K
V
-
R
-
S
N
C
P
K
-----
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
---------------
258
Blastp_CBE
47.02
31%
-69
- C1 -
-
3OMV
1
RAF1_HUMAN
A:
[43-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
------
G
S
G
S
F
G
T
V
Y
K
G
-
K
W
-------
H
-
G
D
----
V
A
V
K
I
L
K
-
V
V
D
P
T
P
E
----
Q
F
-
Q
A
F
R
N
E
V
A
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
-
M
T
K
-
D
----
N
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
-
H
-
V
-
Q
----
E
--------
T
---
K
---
F
Q
M
F
Q
L
I
D
I
A
R
Q
T
A
------
Q
G
M
D
Y
L
H
A
--
K
-------
N
---
I
---
I
---
H
R
D
M
K
S
N
N
I
F
L
-----
H
E
G
L
--------
T
V
K
I
G
D
F
G
L
A
T
V
-------------
P
T
G
--
S
V
L
W
M
A
P
E
-
V
I
-
R
-
M
-
Q
DNNP
F
S
------
F
-
Q
-
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
--
G
E
L
P
Y
S
H
---
I
N
---------------------
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
A
S
P
D
L
-
S
-
K
L
-
Y
-
K
N
C
P
K
-----
A
M
--
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
---------------
250
Blastp_CBE
46.99
31%
-62
- C1 -
-
4MNF
1
BRAF_HUMAN
A:
[53-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
------
G
S
G
S
F
G
T
V
Y
K
G
-
K
W
-------
H
-
G
D
----
V
A
V
K
M
L
N
--
V
T
A
P
T
P
----
Q
Q
L
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
K
-
P
----
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
-
I
----
E
T
K
------
F
---
E
---
M
I
--
K
L
I
D
I
A
R
Q
T
A
------
Q
G
M
D
Y
L
H
A
--
K
-------
S
---
I
---
I
---
H
R
D
L
K
S
N
N
I
F
L
-----
H
E
D
L
--------
T
V
K
I
G
D
F
G
L
A
T
E
------------------
S
I
L
W
M
A
P
E
-
V
I
-
R
-
M
-
Q
DKNP
Y
S
------
F
-
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
---
I
N
---------------------
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
-
K
V
-
R
-
S
N
C
P
K
-----
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
---------------
171
Blastp_CBE
46.95
31%
-60
- C1 -
-
1UWH
1
BRAF_HUMAN
A:
[13-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
------
G
S
G
S
F
G
T
V
Y
K
G
-
K
W
-------
H
-
G
D
----
V
A
V
K
M
L
N
--
V
T
A
P
T
P
----
Q
Q
L
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
-
A
P
----
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
-
I
----
E
T
K
------
F
---
E
---
M
I
--
K
L
I
D
I
A
R
Q
T
A
------
Q
G
M
D
Y
L
H
A
--
K
-------
S
---
I
---
I
---
H
R
D
L
K
S
N
N
I
F
L
-----
H
E
D
L
--------
T
V
K
I
G
D
F
G
L
A
T
V
-------------
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
-
R
-
M
-
Q
DKNP
Y
S
------
F
-
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
---
I
N
---------------------
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
-
K
V
-
R
-
S
N
C
P
K
-----
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
---------------
166
Blastp_CBE
46.46
35%
-16
- C1 -
-
5LPV
1
A:
[7-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
F
A
D
L
L
Q
A
T
N
G
F
H
N
D
S
L
------
I
------
G
S
G
G
F
G
D
V
Y
K
A
-
I
L
K------
D
-
G
S
--
A
-
V
A
I
K
K
L
I
H
V
----
S
G
----
Q
G
D
R
E
F
M
A
E
M
E
T
--
I
G
K
I
K
H
R
N
L
V
P
L
L
G
-
Y
-
C
K
V
G
D
----
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
-
H
D---------
G
------
V
---
K
---
L
N
W
S
T
R
R
K
I
A
I
G
S
A
------
R
G
L
A
F
L
H
H
--
N
CSP----
H
---
I
---
I
---
H
R
D
M
K
S
S
N
V
L
L
-----
D
E
N
L
--------
E
A
R
V
S
D
F
G
M
A
R
L
M
S
A
M
D
H
L
V
T
----
L
A
G
--
T
P
G
Y
V
P
P
E
-
Y
Y
-
Q
-
S
F
R
----
C
S
------
T
-
K
-
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
--
G
-
K
R
P
T
D
SP-
D
F
---------------------
G
---------
G
W
V
K
Q
H
---
A
K
L
R
I
S
D
V
F
D
P
E
L
-
M
-
K
E
-
D
P
A
L
E
I
E
-----
L
L
QH
L
K
V
A
V
A
C
L
D
D
R
A
W
R
R
P
T
M
V
Q
V
M
A
M
F
K
E
I
Q
A
-
369
Blastp_CBE
46.38
32%
-6
- C1 -
-
3EN5
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
350
Blastp_CBE
46.31
32%
-1
- C1 -
-
4O2P
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
---
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
-----------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
442
Blastp_CBE
46.17
32%
-8
- C1 -
-
4K11
1
SRC_HUMAN
A:
[189-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
T
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
R
Q
G
A
-
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
343
Blastp_CBE
46.16
32%
-10
- C1 -
-
5J5S
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
----------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
388
Blastp_CBE
46.05
32%
-10
- C1 -
-
3SVV
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
---
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
-
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
C
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
534
HHSearch
46.00
30%
17
- C1 -
-
5FM3
1
A:
[69-351]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
T
L
------
G
E
G
E
F
G
K
V
V
K
A
-
T
A
FHLKGRA
G
-
Y
T
--
T
-
V
A
V
K
M
L
K
E
N
A
S
---
P
----
S
E
L
R
D
L
L
S
E
F
N
V
--
L
K
Q
V
N
H
P
H
V
I
K
L
Y
G
-
A
-
C
S
Q
D
G
----
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
-
R
-
E
-
S
-----------------
A
---
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
------
Q
G
M
Q
Y
L
A
E
--
M
-------
K
---
L
---
V
---
H
R
D
L
A
A
R
N
I
L
V
-----
A
E
G
R
--------
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
-
G
R
I
--
P
V
K
W
M
A
I
E
-
S
L
-
F
-
D
H
I
----
Y
T
------
T
-
Q
-
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L-
G
-
G
N
P
Y
P
---
G
I
---------------------
P
----
P
E
R
-
L
F
N
L
---
L
K
T
--
G
H
--------
R
-
M
-
E
R
-
P
-
D
N
C
S
E
-----
E
M
--
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
--
394
Blastp_CBE
45.96
32%
-12
- C1 -
-
3GEQ
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
A
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
216
Blastp_CBE
45.93
31%
-59
- C1 -
-
4E26
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
------
G
S
G
S
F
G
T
V
Y
K
G
-
K
W
-------
H
-
G
D
----
V
A
V
K
M
L
N
--
V
T
A
P
T
P
----
Q
Q
L
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
K
-
P
----
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
-
I
----
E
T
K
------
F
---
E
---
M
I
--
K
L
I
D
I
A
R
Q
T
A
------
Q
G
M
D
Y
L
H
A
--
K
-------
S
---
I
---
I
---
H
R
D
L
K
S
N
N
I
F
L
-----
H
E
D
L
--------
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
------
F
E
Q
-
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
-
R
-
M
-
Q
DKNP
Y
S
------
F
-
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
---
I
N
---------------------
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
-
K
V
-
R
-
S
N
C
P
K
-----
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
---------------
342
Blastp_CBE
45.87
32%
-4
- C1 -
-
5J5S
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
--
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
----------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
276
Blastp_CBE
45.85
32%
-7
- C1 -
-
2PL0
1
LCK_HUMAN
A:
[30-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
Q
-----
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
R
E
G
A
-
K
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
------
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
347
Blastp_CBE
45.79
32%
-5
- C1 -
-
4U5J
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------
G
A
-
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
341
Blastp_CBE
45.79
32%
-7
- C1 -
-
5K9I
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
------------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
353
Blastp_CBE
45.71
32%
-11
- C1 -
-
4DGG
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
---------------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
--------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
164
Blastp_CBE
45.69
35%
1
- C1 -
-
4OH4
1
B:
[32-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
F
A
D
L
L
Q
A
T
N
G
F
H
N
D
S
L
------
I
------
G
S
G
G
F
G
D
V
Y
K
A
-
I
L
K------
D
-
G
S
--
A
-
V
A
I
K
K
L
I
H
-------------
D
R
E
F
M
A
E
M
E
T
--
I
G
K
I
K
H
R
N
L
V
P
L
L
G
-
Y
-
C
K
V
G
D
----
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
-
H
-----------------
V
---
K
---
L
N
W
S
T
R
R
K
I
A
I
G
S
A
------
R
G
L
A
F
L
H
H
--
N
CSP----
H
---
I
---
I
---
H
R
D
M
K
S
S
N
V
L
L
-----
D
E
N
L
--------
E
A
R
V
S
D
F
G
M
A
R
L
M
S
A
M
D
H
L
V
T
----
L
A
G
--
T
P
G
Y
V
P
P
E
-
Y
Y
-
Q
-
F
-
R
----
C
S
------
T
-
K
-
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
--
G
-
K
R
P
T
D
SP-
D
F
---------------------
G
----
D
N
N
L
V
G
W
V
K
Q
H
---
A
K
L
R
I
S
D
V
F
D
P
E
L
-
M
-
K
E
-
D
P
A
L
E
I
E
-----
L
L
QH
L
K
V
A
V
A
C
L
D
D
R
A
W
R
R
P
T
M
V
Q
V
M
A
M
F
K
E
I
Q
A
G
441
Blastp_CBE
45.65
32%
-0
- C1 -
-
2H8H
1
SRC_HUMAN
A:
[274-524]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
T
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
R
Q
G
A
-
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
372
Blastp_CBE
45.62
32%
-11
- C1 -
-
3EN4
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
---
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
------------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
212
Blastp_CBE
45.50
31%
-65
- C1 -
-
4EHE
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
------
G
S
G
S
F
G
T
V
Y
K
G
-
K
W
-------
H
-
G
D
----
V
A
V
K
M
L
N
--
V
T
A
P
T
P
----
Q
Q
L
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
K
-
P
----
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
-
I
----
E
T
K
------
F
---
E
---
M
I
--
K
L
I
D
I
A
R
Q
T
A
------
Q
G
M
D
Y
L
H
A
--
K
-------
S
---
I
---
I
---
H
R
D
L
K
S
N
N
I
F
L
-----
H
E
D
L
--------
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
-----------
S
G
--
S
I
L
W
M
A
P
E
-
V
I
-
R
-
M
-
Q
DKNP
Y
S
------
F
-
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
---
I
N
---------------------
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
-
K
V
-
R
-
S
N
C
P
K
-----
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
---------------
439
Blastp_CBE
45.47
31%
-9
- C1 -
-
2SRC
1
SRC_HUMAN
A:
[191-441]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
---------
M
S
P
E
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
T
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
R
Q
G
A
-
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
348
Blastp_CBE
45.43
32%
-7
- C1 -
-
4U5J
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------
G
A
-
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
229
Blastp_CBE
45.40
31%
-54
- C1 -
-
3PRI
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
------
G
S
G
S
F
G
T
V
Y
K
G
-
K
W
-------
H
-
G
D
----
V
A
V
K
M
L
N
--
V
T
A
P
T
P
----
Q
Q
L
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
K
-
P
----
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
-
I
----
E
T
K
------
F
---
E
---
M
I
--
K
L
I
D
I
A
R
Q
T
A
------
Q
G
M
D
Y
L
H
A
--
K
-------
S
---
I
---
I
---
H
R
D
L
K
S
N
N
I
F
L
-----
H
E
D
L
--------
T
V
K
I
G
D
F
G
L
A
T
V
-------------
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
-
R
-
M
-
Q
DKNP
Y
S
------
F
-
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
---
I
N
---------------------
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
-
K
V
-
R
-
S
N
C
P
K
-----
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
---------------
228
Blastp_CBE
45.37
31%
-54
- C1 -
-
3PRI
1
B:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
------
G
S
G
S
F
G
T
V
Y
K
G
-
K
W
-------
H
-
G
D
----
V
A
V
K
M
L
N
--
V
T
A
P
T
P
----
Q
Q
L
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
K
-
P
----
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
-
I
----
E
T
K
------
F
---
E
---
M
I
--
K
L
I
D
I
A
R
Q
T
A
------
Q
G
M
D
Y
L
H
A
--
K
-------
S
---
I
---
I
---
H
R
D
L
K
S
N
N
I
F
L
-----
H
E
D
L
--------
T
V
K
I
G
D
F
G
L
A
T
V
-------------
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
-
R
-
M
-
Q
DKNP
Y
S
------
F
-
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
---
I
N
---------------------
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
-
K
V
-
R
-
S
N
C
P
K
-----
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
---------------
371
Blastp_CBE
45.34
32%
-14
- C1 -
-
3EN4
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
-----------
A
-
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
393
Blastp_CBE
45.33
32%
-14
- C1 -
-
3GEQ
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
A
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
-----------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
366
Blastp_CBE
45.19
32%
-7
- C1 -
-
3F6X
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
------
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-----------
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
344
Blastp_CBE
45.18
32%
-7
- C1 -
-
4YBK
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
-------------
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
390
Blastp_CBE
45.04
31%
-5
- C1 -
-
2ZVA
1
LYN_MOUSE
A:
[19-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
-
N
S
--
T
K
V
A
V
K
T
L
K
P
G
T
M
S
V
---------
Q
A
F
L
E
E
A
N
L
--
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
-
V
-
V
T
K
E
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
G
------
K
---
V
---
L
L
P
K
L
I
D
F
S
A
Q
-
I
A
------
E
G
M
A
Y
I
E
R
--
K
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
V
L
V
-----
S
E
S
L
--------
M
C
K
I
A
D
F
G
L
A
R
V
I
E
----
T
A
R
E
G
A
-
K
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
C
----
F
T
------
I
-
K
-
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
--
Y
-
G
K
I
P
Y
---
P
G
---------------------
R
----
T
N
A
---
D
V
M
S
A
L
S
------
Q
G
Y
R
M
P
R
M
-
E
-
N
C
-
P
-----
D
-----
E
L
--
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
---
354
Blastp_CBE
45.01
32%
-6
- C1 -
-
4DGG
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
------------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
339
Blastp_CBE
45.00
32%
-12
- C1 -
-
5XP5
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------
G
A
-
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
336
Blastp_CBE
44.97
32%
-7
- C1 -
-
5XP7
2
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
317
Blastp_CBE
44.96
32%
-8
- C1 -
-
3U51
2
SRC_CHICK
A:
[14-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
------------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
440
Blastp_CBE
44.94
31%
-12
- C1 -
-
1Y57
1
SRC_HUMAN
A:
[191-441]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
---------
M
S
P
E
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
T
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
R
Q
G
A
-
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
519
Blastp_CBE
44.89
31%
-6
- C1 -
-
3VS3
1
HCK_HUMAN
B:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
E
-----------
K
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
526
Blastp_CBE
44.78
31%
-2
- C1 -
-
3VS0
1
HCK_HUMAN
A:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
522
Blastp_CBE
44.78
31%
-6
- C1 -
-
3VS2
1
HCK_HUMAN
A:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
358
Blastp_CBE
44.67
32%
-14
- C1 -
-
3UQG
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
-----------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
520
Blastp_CBE
44.63
31%
-10
- C1 -
-
3VS3
1
HCK_HUMAN
A:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
319
Blastp_CBE
44.60
32%
-25
- C1 -
-
1YOM
1
SRC_HUMAN
B:
[22-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
T
G
K
YLRL--
P
---
Q
---
L
V
-
D
M
S
A
Q
I
A
S
G
M
A
----------
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
-------------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
443
Blastp_CBE
44.57
31%
-6
- C1 -
-
1KSW
1
SRC_HUMAN
A:
[191-441]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
---------
M
S
P
E
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
T
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
R
Q
G
A
-
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
313
Blastp_CBE
44.50
32%
-3
- C1 -
-
4MXO
1
SRC_HUMAN
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
T
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
516
Blastp_CBE
44.42
31%
-5
- C1 -
-
3VS5
1
HCK_HUMAN
A:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
375
Blastp_CBE
44.44
32%
-7
- C1 -
-
3DQX
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-------
Q
G
A
-
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
349
Blastp_CBE
44.42
32%
-12
- C1 -
-
4O2P
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
-
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
518
Blastp_CBE
44.43
31%
-5
- C1 -
-
3VS4
1
HCK_HUMAN
A:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
E
------------
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
515
Blastp_CBE
44.40
31%
-1
- C1 -
-
3VS5
1
HCK_HUMAN
B:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
208
Blastp_CBE
44.42
31%
-65
- C1 -
-
4PP7
1
BRAF_HUMAN
A:
[41-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
------
G
S
G
S
F
G
T
V
Y
K
G
-
K
W
-------
H
-
G
D
----
V
A
V
K
M
L
N
--
V
T
A
P
T
P
----
Q
Q
L
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
K
-
P
----
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
-
I
----
E
T
K
------
F
---
E
---
M
I
--
K
L
I
D
I
A
R
Q
T
A
------
Q
G
M
D
Y
L
H
A
--
K
-------
S
---
I
---
I
---
H
R
D
L
K
S
N
N
I
F
L
-----
H
E
D
L
--------
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
--------
L
S
G
--
S
I
L
W
M
A
P
E
-
V
I
-
R
-
M
-
Q
DKNP
Y
S
------
F
-
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
---
I
N
---------------------
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
-
K
V
-
R
-
S
N
C
P
K
-----
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
---------------
398
Blastp_CBE
44.40
31%
-8
- C1 -
-
6HVE
1
?
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
338
Blastp_CBE
44.34
32%
-5
- C1 -
-
5XP5
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------
G
A
-
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
389
Blastp_CBE
44.32
32%
-1
- C1 -
-
3SVV
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
-
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
C
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
-------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
261
Blastp_CBE
44.21
32%
2
- C1 -
-
2OF4
1
LCK_HUMAN
A:
[20-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
-----
Q
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
R
E
G
A
-
K
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
------
G
Y
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
365
Blastp_CBE
44.16
32%
0
- C1 -
-
3F6X
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
-
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
------------
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
529
Blastp_CBE
44.15
31%
-7
- C1 -
-
3VRY
1
HCK_HUMAN
B:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
414
Blastp_CBE
44.10
31%
-10
- C1 -
-
5T0P
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
C
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
-----------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
436
Blastp_CBE
44.09
31%
-9
- C1 -
-
2HWP
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
-
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
-------------------
F
L
Q
-
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
--
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
-------------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
392
Blastp_CBE
44.06
31%
-11
- C1 -
-
2ZV8
1
LYN_MOUSE
A:
[19-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
-
N
S
--
T
K
V
A
V
K
T
L
K
P
G
T
M
S
V
---------
Q
A
F
L
E
E
A
N
L
--
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
-
V
-
V
T
K
E
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
G
------
K
---
V
---
L
L
P
K
L
I
D
F
S
A
Q
-
I
A
------
E
G
M
A
Y
I
E
R
--
K
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
V
L
V
-----
S
E
S
L
--------
M
C
K
I
A
D
F
G
L
A
R
V
I
-------
R
E
G
A
-
K
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
C
----
F
T
------
I
-
K
-
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
--
Y
-
G
K
I
P
Y
---
P
G
---------------------
R
----
T
N
A
---
D
V
M
S
A
L
S
------
Q
G
Y
R
M
P
R
M
-
E
-
N
C
-
P
-----
D
-----
E
L
--
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
---
364
Blastp_CBE
44.03
32%
-6
- C1 -
-
3F6X
1
SRC_CHICK
C:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
-----
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-----------
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
376
Blastp_CBE
43.97
32%
-12
- C1 -
-
3DQX
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------
G
A
-
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
357
Blastp_CBE
43.95
32%
-9
- C1 -
-
3UQG
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
----
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
-----
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
-----------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
305
Blastp_CBE
43.95
32%
-4
* C1 *
-
2BDJ
1
SRC_HUMAN
A:
[18-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
T
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
-
266
Blastp_CBE
43.95
32%
-2
- C1 -
-
3BYU
1
LCK_HUMAN
A:
[26-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
Q
-----
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
----------------
K
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
------
G
Y
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
335
Blastp_CBE
43.94
32%
-9
- C1 -
-
4MCV
1
SRC_CHICK
A:
[17-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
265
Blastp_CBE
43.91
32%
-3
- C1 -
-
2OFV
1
LCK_HUMAN
A:
[25-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
Q
-----
G
-----------
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
---------------------
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
------
G
Y
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
363
Blastp_CBE
43.87
32%
-9
- C1 -
-
3F6X
1
SRC_CHICK
D:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-----------
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
420
Blastp_CBE
43.85
31%
-13
- C1 -
-
3TZ9
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
-------------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
267
Blastp_CBE
43.85
32%
-1
- C1 -
-
3BYS
1
LCK_HUMAN
A:
[26-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
Q
-----
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
---------------------
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
------
G
Y
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
377
Blastp_CBE
43.81
32%
-12
- C1 -
-
3D7T
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
------------
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
359
Blastp_CBE
43.79
32%
-0
- C1 -
-
3UQF
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
--------
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
----------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
316
Blastp_CBE
43.79
32%
-4
- C1 -
-
3U51
1
SRC_CHICK
B:
[14-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
----------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
307
Blastp_CBE
43.78
32%
-8
- C1 -
-
2BDF
1
SRC_HUMAN
A:
[18-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
T
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
514
Blastp_CBE
43.73
31%
-7
- C1 -
-
3VS6
1
HCK_HUMAN
A:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
503
Blastp_CBE
43.72
31%
2
- C1 -
-
5H0G
1
HCK_HUMAN
A:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
A
R
E
G
A
-
K
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
521
Blastp_CBE
43.69
31%
-12
- C1 -
-
3VS2
1
HCK_HUMAN
B:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
340
Blastp_CBE
43.71
32%
-8
- C1 -
-
5K9I
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
--------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
296
Blastp_CBE
43.69
31%
4
- C1 -
-
3MPM
2
LCK_HUMAN
A:
[16-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
-----
Q
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
N
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
R
-----
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
------
G
Y
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
505
Blastp_CBE
43.60
31%
2
- C1 -
-
5H0B
1
HCK_HUMAN
A:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
A
R
E
G
A
-
K
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
423
Blastp_CBE
43.59
31%
-10
- C1 -
-
3TZ8
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
-----------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
506
Blastp_CBE
43.58
31%
1
- C1 -
-
5H09
1
HCK_HUMAN
A:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
A
R
E
G
A
-
K
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
477
Blastp_CBE
43.53
31%
-6
- C1 -
-
5ZJ6
1
HCK_HUMAN
B:
[33-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
A
R
E
G
A
-
K
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
------
373
Blastp_CBE
43.50
32%
-8
- C1 -
-
3EL8
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
--------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
279
Blastp_CBE
43.51
32%
-4
- C1 -
-
2OG8
1
LCK_HUMAN
A:
[15-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
-----
Q
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
---------------------
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
------
G
Y
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
314
Blastp_CBE
43.50
32%
-4
- C1 -
-
4MXO
1
SRC_HUMAN
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
T
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
306
Blastp_CBE
43.45
32%
-4
- C1 -
-
2BDF
1
SRC_HUMAN
B:
[18-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
T
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
---------
A
-
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
263
Blastp_CBE
43.42
32%
1
- C1 -
-
3B2W
1
LCK_HUMAN
A:
[25-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
Q
-----
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
--
G
A
-
K
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
------
G
Y
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
312
Blastp_CBE
43.41
32%
-12
- C1 -
-
6ATE
1
SRC_HUMAN
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
-------
P
E
--------
A
F
--
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
T
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
391
Blastp_CBE
43.36
31%
-7
- C1 -
-
2ZV9
1
LYN_MOUSE
A:
[19-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
-
N
S
--
T
K
V
A
V
K
T
L
K
P
G
T
M
S
V
---------
Q
A
F
L
E
E
A
N
L
--
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
-
V
-
V
T
K
E
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
G
------
K
---
V
---
L
L
P
K
L
I
D
F
S
A
Q
-
I
A
------
E
G
M
A
Y
I
E
R
--
K
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
V
L
V
-----
S
E
S
L
--------
M
C
K
I
A
D
F
G
L
A
R
V
I
--------
E
G
A
-
K
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
C
----
F
T
------
I
-
K
-
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
--
Y
-
G
K
I
P
Y
---
P
G
---------------------
R
----
T
N
A
---
D
V
M
S
A
L
S
------
Q
G
Y
R
M
P
R
M
-
E
-
N
C
-
P
-----
D
-----
E
L
--
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
---
361
Blastp_CBE
43.34
32%
-2
- C1 -
-
3G6G
2
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
---------------
G
A
-
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
415
Blastp_CBE
43.33
31%
-13
- C1 -
-
5T0P
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
C
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
-----------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
524
Blastp_CBE
43.30
31%
-5
- C1 -
-
3VS1
1
HCK_HUMAN
A:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
422
Blastp_CBE
43.31
31%
-8
- C1 -
-
3TZ8
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
----------------
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
331
Blastp_CBE
43.30
32%
-8
- C1 -
-
3G6H
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
426
Blastp_CBE
43.28
31%
-7
- C1 -
-
3G5D
2
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
---
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
----
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
--------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
327
Blastp_CBE
43.26
31%
-5
- C1 -
-
4MXY
1
SRC_HUMAN
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
T
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
325
Blastp_CBE
43.26
31%
-5
- C1 -
-
4MXZ
1
SRC_HUMAN
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
T
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
360
Blastp_CBE
43.25
32%
-8
- C1 -
-
3UQF
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
--------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
502
Blastp_CBE
43.21
31%
-1
- C1 -
-
5H0H
1
HCK_HUMAN
A:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
A
R
E
G
A
-
K
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
379
Blastp_CBE
43.21
32%
-4
- C1 -
-
2OIQ
3
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
-------------
G
A
-
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
295
Blastp_CBE
43.21
31%
2
- C1 -
-
4C3F
1
LCK_HUMAN
A:
[16-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
-----
Q
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
N
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
R
-----
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
------
G
Y
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
418
Blastp_CBE
43.20
31%
-3
- C1 -
-
5SWH
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
C
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
----------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
478
Blastp_CBE
43.13
31%
-6
- C1 -
-
5ZJ6
1
HCK_HUMAN
A:
[33-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
A
R
E
G
A
-
K
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
------
337
Blastp_CBE
43.15
32%
-4
- C1 -
-
5XP7
2
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
507
Blastp_CBE
43.14
31%
-20
- C1 -
-
4LUE
3
HCK_HUMAN
B:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
-----------------
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
-
A
I
-
N
--------
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
408
Blastp_CBE
43.13
31%
-15
- C1 -
-
3F3W
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
-----------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
513
Blastp_CBE
43.07
31%
-0
- C1 -
-
3VS6
1
HCK_HUMAN
B:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
401
Blastp_CBE
43.09
31%
-17
- C1 -
-
5D11
2
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
------------------
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
--------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
407
Blastp_CBE
43.07
31%
-7
- C1 -
-
3F3W
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
-----------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
310
Blastp_CBE
43.02
32%
-6
- C1 -
-
4MXX
1
SRC_HUMAN
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
T
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
T
D
F
G
L
A
R
L
I
E
------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
551
Fugue
43.01
31%
-10
- C1 -
-
1BYG
1
CSK_HUMAN
A:
[15-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
---------------------
N
M
K
E
L
K
L
L
Q
T
I
------
G
K
G
E
F
G
D
V
M
L
G
-
D
Y
RG--------
N
--
K
-
V
A
V
K
C
I
K
------------
N
D
A
Q
A
F
L
A
E
A
S
V
--
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
-
V
I
V
--
E
E
----
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
-
R
-
S
-
R
G-----
R
------
S
---
V
---
L
G
G
D
C
L
L
K
F
S
L
D
V
C
------
E
A
M
E
Y
L
E
G
--
N
-------
N
---
F
---
V
---
H
R
D
L
A
A
R
N
V
L
V
-----
S
E
D
N
--------
V
A
K
V
S
D
F
G
--------------------LL
P
V
K
W
T
A
P
E
-
A
L
-
R
E
K
-
K
----
F
S
------
T
-
K
-
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
FG
R
-
V
P
Y
P
R
---
I
P
---------------------
L
-----
K
D
V
V
P
R
V
E
K
-------------
G
Y
K
M
-
D
-
A
P
-
D
-
G
C
P
-
P
-----
A
V
--
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
525
Blastp_CBE
42.99
31%
-0
- C1 -
-
3VS0
1
HCK_HUMAN
B:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
467
Blastp_CBE
42.95
31%
-6
- C1 -
-
2HK5
1
HCK_HUMAN
A:
[22-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
A
R
E
G
A
-
K
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
------
432
Blastp_CBE
42.93
31%
-13
- C1 -
-
3F3T
2
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
-----------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
387
Blastp_CBE
42.90
32%
-17
- C1 -
-
1YOL
1
SRC_HUMAN
A:
[22-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
--
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
T
G
K
YLRL--
P
---
Q
---
L
V
-
D
M
S
A
Q
I
A
S
G
M
A
----------
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
------------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
264
Blastp_CBE
42.89
32%
-7
- C1 -
-
2OFV
1
?
B:
[25-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
Q
-----
G
---------
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
---------------
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
-------
I
Q
N
L
E
-------
G
Y
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
386
Blastp_CBE
42.86
32%
-16
- C1 -
-
1YOL
1
SRC_HUMAN
B:
[22-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
--
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
T
G
K
YLRL--
P
---
Q
---
L
V
-
D
M
S
A
Q
I
A
S
G
M
A
----------
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
------------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
419
Blastp_CBE
42.85
31%
-0
- C1 -
-
5SWH
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
C
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
----------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
352
Blastp_CBE
42.81
32%
-5
- C1 -
-
4FIC
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
---
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
-----------------
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
------------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
511
Blastp_CBE
42.80
31%
0
- C1 -
-
3VS7
1
HCK_HUMAN
B:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
-------------------
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
400
Blastp_CBE
42.79
31%
-7
- C1 -
-
5D12
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
------
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
384
Blastp_CBE
42.78
32%
-10
- C1 -
-
3OEZ
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
------------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
471
Blastp_CBE
42.75
31%
-1
- C1 -
-
2HCK
1
HCK_HUMAN
B:
[189-426]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
G
A
K
F
P
--------------
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
504
Blastp_CBE
42.74
31%
1
- C1 -
-
5H0E
1
HCK_HUMAN
A:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
A
R
E
G
A
-
K
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
427
Blastp_CBE
42.67
31%
-9
- C1 -
-
3G5D
2
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
---
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
------
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
--------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
262
Blastp_CBE
42.61
32%
4
- C1 -
-
2OF2
1
LCK_HUMAN
A:
[20-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
-----
Q
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
Y
T
A
R
E
G
A
-
K
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
------
G
Y
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
430
Blastp_CBE
42.56
31%
-12
- C1 -
-
3F3U
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
---
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
-----------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
334
Blastp_CBE
42.56
32%
-7
- C1 -
-
4MCV
1
SRC_CHICK
B:
[17-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
-
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
------------
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
362
Blastp_CBE
42.51
32%
-1
- C1 -
-
3G6G
3
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
--------------
G
A
-
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
512
Blastp_CBE
42.38
31%
-1
- C1 -
-
3VS7
1
HCK_HUMAN
A:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
------------------
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
374
Blastp_CBE
42.33
32%
-6
- C1 -
-
3EL7
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
--
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
-
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-------
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
----------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
431
Blastp_CBE
42.28
31%
-11
- C1 -
-
3F3U
2
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
-----------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
351
Blastp_CBE
42.23
32%
-10
- C1 -
-
4FIC
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
-----------------------
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
------------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
416
Blastp_CBE
42.12
31%
-4
- C1 -
-
5SYS
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
C
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
----------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
382
Blastp_CBE
42.05
32%
-3
- C1 -
-
3QLF
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
---
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
----------------
A
-
K
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
429
Blastp_CBE
42.04
31%
-5
- C1 -
-
3F3V
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
-----------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
385
Blastp_CBE
42.00
32%
-9
- C1 -
-
3OEZ
2
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
-----------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
380
Blastp_CBE
41.97
32%
-16
- C1 -
-
3QLG
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
-----
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
--------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
278
Blastp_CBE
41.97
32%
-3
- C1 -
-
2OG8
1
?
B:
[15-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
-----
Q
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
--------------------
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
------
G
Y
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
417
Blastp_CBE
41.93
31%
-8
- C1 -
-
5SYS
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
C
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
----------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
381
Blastp_CBE
41.92
32%
-6
- C1 -
-
3QLG
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
------------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
402
Blastp_CBE
41.91
31%
-14
- C1 -
-
5D11
2
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
--------------
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
-----------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
333
Blastp_CBE
41.88
32%
-6
- C1 -
-
4LGG
1
SRC_CHICK
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
--
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
----------------
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
-----
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
--------------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
329
Blastp_CBE
41.86
32%
-6
- C1 -
-
4LGH
1
SRC_CHICK
B:
[16-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
-
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
-------------------
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
474
Blastp_CBE
41.82
31%
2
- C1 -
-
1AD5
1
HCK_HUMAN
A:
[189-426]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
G
A
K
F
P
--------------
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
413
Blastp_CBE
41.82
31%
1
- C1 -
-
5TEH
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
C
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
------------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
410
Blastp_CBE
41.78
31%
-10
- C1 -
-
2QQ7
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
-
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
--------------------
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
397
Blastp_CBE
41.77
31%
-9
- C1 -
-
6HVE
1
?
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
--------------------
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
--------------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
311
Blastp_CBE
41.67
31%
-20
- C1 -
-
5XY1
1
LYN_HUMAN
A:
[19-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
-
N
S
--
T
K
V
A
V
K
T
L
K
P
G
T
M
S
V
---------
Q
A
F
L
E
E
A
N
L
--
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
-
V
-
V
T
R
E
E
----
P
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
G
------
K
---
V
---
L
L
P
K
L
I
D
F
S
A
Q
-
I
A
------
E
G
M
A
Y
I
E
R
--
K
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
V
L
V
-----
S
E
S
L
--------
M
C
K
I
A
D
F
G
L
A
R
V
-------------
K
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
C
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
------------------------------------------------
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
T
A
L
S
-
Q
-
G
Y
-
R
-
M
P
R
V
E
NCPD-
E
L
--
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
---
320
Blastp_CBE
41.62
32%
-25
- C1 -
-
1YOM
1
SRC_HUMAN
A:
[22-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
T
G
K
YLRL--
P
---
Q
---
L
V
-
D
M
S
A
Q
I
A
S
G
M
A
----------
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
--------------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
435
Blastp_CBE
41.50
31%
-17
- C1 -
-
2HWP
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
---
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
-----------------------
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
---------------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
396
Blastp_CBE
41.45
31%
-11
- C1 -
-
6HVF
3
?
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
--
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
-------------------
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
--------------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
412
Blastp_CBE
41.42
31%
-5
- C1 -
-
5TEH
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
C
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
-----------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
383
Blastp_CBE
41.40
32%
-16
- C1 -
-
3QLF
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
------------------
L
Q
E
A
Q
V
--
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
-------------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
428
Blastp_CBE
41.38
31%
-14
- C1 -
-
3F3V
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
-----------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
510
Blastp_CBE
41.32
31%
-7
- C1 -
-
4LUD
1
HCK_HUMAN
A:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
----
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
----
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
473
Blastp_CBE
41.27
31%
3
- C1 -
-
1AD5
1
HCK_HUMAN
B:
[189-426]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
G
A
K
F
P
--------------
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
523
Blastp_CBE
41.25
31%
-1
- C1 -
-
3VS1
1
HCK_HUMAN
B:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
508
Blastp_CBE
41.21
31%
3
- C1 -
-
4LUE
3
HCK_HUMAN
A:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
--------------
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
370
Blastp_CBE
41.10
32%
-7
- C1 -
-
3EN5
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
-
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
-----------------------
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
-------------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
509
Blastp_CBE
41.07
31%
1
- C1 -
-
4LUD
2
HCK_HUMAN
B:
[195-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
---
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
I
-----------------
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
438
Blastp_CBE
41.05
31%
-3
- C1 -
-
2HWO
2
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
-
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
----------------
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
-------
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
----------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
292
Blastp_CBE
40.98
31%
-20
- C1 -
-
2ZM4
2
LCK_HUMAN
A:
[26-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
Q
-----
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
E
G
A
K
-
F
----
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
------
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
479
Blastp_CBE
40.92
31%
-24
- C1 -
-
3D7T
1
CSK_HUMAN
A:
[20-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
------
G
K
G
E
F
G
D
V
M
L
G
-
D
Y
-------
R
-
G
N
--
K
-
V
A
V
K
C
------
I
K
N
D
----
A
T
A
Q
A
F
L
A
E
A
S
V
--
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
-
V
E
E
K
G
----
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
-
R
-
S
------
R
G
R
------
S
---
V
---
L
G
G
D
C
L
L
K
F
S
L
D
V
C
------
E
A
M
E
Y
L
E
G
--
N
-------
N
---
F
---
V
---
H
R
D
L
A
A
R
N
V
L
V
-----
S
E
D
N
--------
V
A
K
V
S
D
F
G
----------------------
P
V
K
W
T
A
P
E
-
A
L
-
R
E
A
-
A
----
F
S
------
T
-
K
-
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
------------
F
G
---------------------
R
----
V
P
Y
P
R
I
P
L
K
D
V
V
P
R
V
E
K
G
Y
------
K
M
---
D
A
-
P
-
D
G
C
P
P
-----
A
V
--
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
---
330
Blastp_CBE
40.87
32%
-7
- C1 -
-
4LGH
1
SRC_CHICK
A:
[16-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
--
G
E
V
W
M
G
-
T
W
-------
N
-
G
---
T
R
V
A
I
K
T
L
---------------------
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
--------------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
332
Blastp_CBE
40.73
32%
-0
- C1 -
-
4LGG
1
B:
[5-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
------
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
--------------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
271
Blastp_CBE
40.64
31%
-14
- C1 -
-
3KMM
1
LCK_HUMAN
A:
[29-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
-----
Q
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
E
G
A
K
-
F
----
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
------
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
403
Blastp_CBE
40.63
31%
-7
- C1 -
-
5D10
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
----------------------
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
482
Blastp_CBE
40.62
31%
-20
- C1 -
-
1BYG
1
CSK_HUMAN
A:
[29-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
------
G
K
G
E
F
G
D
V
M
L
G
-
D
Y
-------
R
-
G
N
--
K
-
V
A
V
K
C
------
I
K
N
D
------
A
Q
A
F
L
A
E
A
S
V
--
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
-
V
E
E
------
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
-
R
-
S
------
R
G
R
------
S
---
V
---
L
G
G
D
C
L
L
K
F
S
L
D
V
C
------
E
A
M
E
Y
L
E
G
--
N
-------
N
---
F
---
V
---
H
R
D
L
A
A
R
N
V
L
V
-----
S
E
D
N
--------
V
A
K
V
S
D
F
G
L
----------------
L
----
P
V
K
W
T
A
P
E
-
A
L
-
R
E
K
-
K
----
F
S
------
T
-
K
-
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
----
F
G
R
V
P
---
Y
P
---------------------
R
----
I
P
--
L
K
D
V
V
P
R
V
E
K
G
Y
K
M
------------
D
A
-
P
-
D
G
C
P
P
-----
A
V
--
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
---
395
Blastp_CBE
40.57
31%
-2
- C1 -
-
6HVF
2
?
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
--
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
-------------------
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
------------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
367
Blastp_CBE
40.46
32%
-3
- C1 -
-
3EN7
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
---
G
E
V
W
M
G
-
T
W
-------
N
-----
T
R
V
A
I
K
T
L
K
P
----------------
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
--------------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
288
Blastp_CBE
40.33
31%
-16
- C1 -
-
3AC3
1
LCK_HUMAN
A:
[26-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
Q
-----
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
E
G
A
K
-
F
----
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
------
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
324
Blastp_CBE
40.18
31%
-22
- C1 -
-
3DQW
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
Q
G
A
K
-
F
----
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
409
Blastp_CBE
40.17
31%
-12
- C1 -
-
2QQ7
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
--
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
----------------------
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
322
Blastp_CBE
40.02
31%
-20
- C1 -
-
3DQW
1
SRC_CHICK
C:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
Q
G
A
K
-
F
----
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
472
Blastp_CBE
39.91
31%
5
- C1 -
-
2HCK
1
HCK_HUMAN
A:
[189-426]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-------
K
-
H
T
--
K
-
V
A
V
K
T
M
K
P
G
-
S
M
S
V
E
--------
A
F
L
A
E
A
N
V
--
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
-
V
-
V
T
K
-
E
----
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
S
------
K
QPL
P
---
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
----------
F
I
E
Q
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
L
--------
V
C
K
I
A
D
F
G
L
A
R
V
G
A
K
F
P
--------------
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
S
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
------------
Y
G
---------------------
R
----
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
------
R
M
-
P
-
R
P
-
E
-
N
C
P
-
E
-----
E
L
--
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---
309
Blastp_CBE
39.91
32%
-1
- C1 -
-
4MXX
1
SRC_HUMAN
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
T
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
T
D
F
G
L
-----------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
444
Blastp_CBE
39.88
31%
-16
- C1 -
-
2DQ7
1
FYN_HUMAN
X:
[16-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
N
G
Q
F
G
E
V
W
M
G
-
T
W
-------
N
G
N
T
--
K
-
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
S
F
L
E
E
A
Q
I
--
M
K
K
L
K
H
D
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
-
K
-
D
-
G
----
E
G
R
------
A
-------
L
K
L
P
N
L
V
D
M
A
A
Q
V
A
------
A
G
M
A
Y
I
E
R
--
M
-------
N
---
Y
---
I
---
H
R
D
L
R
S
A
N
I
L
V
-----
G
N
G
L
--------
I
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
Q
G
A
K
-
F
----
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
V
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
N
N
R
E
V
L
E
Q
V
E
R
G
Y
------
R
M
-
P
-
C
P
-
Q
-
D
C
P
I
------
S
L
--
H
E
L
M
I
H
C
W
K
K
D
P
E
E
R
P
T
F
E
Y
L
Q
S
F
L
E
D
----
315
Blastp_CBE
39.67
31%
-8
- C1 -
-
1QPD
1
?
A:
[20-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
A
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
-----
Q
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
A
E
T
A
R
E
G
A
K
-
F
----
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
------
G
Y
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
283
Blastp_CBE
39.67
31%
-16
- C1 -
-
3ACK
2
LCK_HUMAN
A:
[26-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
Q
-----
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
E
G
A
K
-
F
----
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
------
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
287
Blastp_CBE
39.65
31%
-17
- C1 -
-
3AC4
2
LCK_HUMAN
A:
[26-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
Q
-----
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
E
G
A
K
-
F
----
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
------
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
368
Blastp_CBE
39.62
32%
-10
- C1 -
-
3EN6
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
--
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
----------------------
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
--------
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
------------------------
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
399
Blastp_CBE
39.60
31%
-2
- C1 -
-
5D12
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
--------
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
-----------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
272
Blastp_CBE
39.57
31%
-15
- C1 -
-
1QPJ
1
LCK_HUMAN
A:
[20-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
-----
Q
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
E
G
A
K
-
F
----
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
------
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
269
Blastp_CBE
39.56
31%
-10
- C1 -
-
3BYO
1
?
A:
[20-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
-----
Q
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
E
G
A
K
-
F
----
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
------
G
Y
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
291
Blastp_CBE
39.37
31%
-20
- C1 -
-
2ZYB
1
LCK_HUMAN
A:
[26-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
Q
-----
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
E
G
A
K
-
F
----
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
------
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
323
Blastp_CBE
39.36
31%
-20
- C1 -
-
3DQW
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
Q
G
A
K
-
F
----
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
273
Blastp_CBE
39.33
31%
-11
- C1 -
-
1QPE
1
LCK_HUMAN
A:
[20-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
-----
Q
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
E
G
A
K
-
F
----
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
------
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
289
Blastp_CBE
39.29
31%
-16
- C1 -
-
3AC2
3
LCK_HUMAN
A:
[26-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
Q
-----
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
E
G
A
K
-
F
----
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
------
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
321
Blastp_CBE
39.28
31%
-16
- C1 -
-
3DQW
1
SRC_CHICK
D:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
C
F
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
F
L
Q
E
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
Q
G
A
K
-
F
----
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
275
Blastp_CBE
39.27
31%
-14
- C1 -
-
3KXZ
1
LCK_HUMAN
A:
[28-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
-----
Q
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
E
G
A
K
-
F
----
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
------
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
285
Blastp_CBE
39.07
31%
-11
- C1 -
-
3AC8
1
LCK_HUMAN
A:
[26-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
Q
-----
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
E
G
A
K
-
F
----
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
------
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
284
Blastp_CBE
39.05
31%
-12
- C1 -
-
3ACJ
2
LCK_HUMAN
A:
[26-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
Q
-----
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
E
G
A
K
-
F
----
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
------
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
290
Blastp_CBE
39.00
31%
-16
- C1 -
-
3AC1
3
LCK_HUMAN
A:
[26-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
Q
-----
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
E
G
A
K
-
F
----
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
------
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
437
Blastp_CBE
38.92
31%
-7
- C1 -
-
2HWO
2
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
--
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
----------------------
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
--------------------
F
---
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
404
Blastp_CBE
38.85
31%
-7
- C1 -
-
5D10
1
SRC_CHICK
A:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
----
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
P
G
T
-
M
S
P
E
--------
A
----
A
Q
V
--
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
------------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
286
Blastp_CBE
38.84
31%
-13
- C1 -
-
3AC5
2
LCK_HUMAN
A:
[26-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
Q
-----
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
E
G
A
K
-
F
----
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
------
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
293
Blastp_CBE
38.83
31%
-12
- C1 -
-
2ZM1
2
LCK_HUMAN
A:
[26-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
Q
-----
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
E
G
A
K
-
F
----
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
------
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
277
Blastp_CBE
38.68
31%
-12
- C1 -
-
3BYM
1
LCK_HUMAN
A:
[21-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
-----
Q
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
E
G
A
K
-
F
----
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
------
G
Y
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
280
Blastp_CBE
38.35
31%
-14
- C1 -
-
3AD6
2
LCK_HUMAN
A:
[26-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
Q
-----
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
E
G
A
K
-
F
----
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
------
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
274
Blastp_CBE
38.31
31%
-12
- C1 -
-
1QPC
2
?
A:
[20-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
-----
Q
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
E
G
A
K
-
F
----
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
------
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
281
Blastp_CBE
38.10
31%
-15
- C1 -
-
3AD5
3
LCK_HUMAN
A:
[26-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
Q
-----
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
E
G
A
K
-
F
----
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
------
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
405
Blastp_CBE
37.87
31%
-6
- C1 -
-
3LOK
1
SRC_CHICK
B:
[25-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
------
G
Q
G
--
G
E
V
W
M
G
-
T
W
-------
N
-
G
T
--
T
R
V
A
I
K
T
L
K
--------------------------
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
-
V
-
V
S
E
-
E
----
P
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-
G
-
E
----
M
G
K
------
Y
-------
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
------
S
G
M
A
Y
V
E
R
--
M
-------
N
---
Y
---
V
---
H
R
D
L
R
A
A
N
I
L
V
-----
G
E
N
L
--------
V
C
K
V
A
D
F
G
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
-
Y
-
G
-
R
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
------------
K
G
---------------------
R
----
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
--------
M
-
P
C
-
P
-
P
E
C
P
E
-----
S
L
--
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
282
Blastp_CBE
37.78
31%
-14
- C1 -
-
3AD4
3
LCK_HUMAN
A:
[26-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
Q
-----
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
E
G
A
K
-
F
----
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
------
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
496
Blastp_CBE
37.29
35%
-16
- C1 -
-
3Q4T
7
AVR2A_HUMAN
B:
[35-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
F
G
C
V
W
K
A
-
Q
L
-------
L
-
N
E
--
Y
-
V
A
V
K
-------
I
F
P
I
----
Q
D
K
Q
S
W
Q
N
E
Y
E
V
YS
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
-
A
-
E
K
R
G
T
SVDV
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
-
K
----------
A
------
N
---
V
---
V
S
W
N
E
L
C
H
I
A
E
T
M
A
------
R
G
L
A
Y
L
H
E
--
D
IPGLKDG
H
---
K
PAI
S
---
H
R
D
I
K
S
K
N
V
L
L
-----
K
N
N
L
--------
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
--
T
H
G
-
Q
V
G
--
T
R
R
Y
M
A
P
E
-
V
L
-
E
-
G
-
A
----
I
N
FQRDAF
L
-
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
--
R
-
C
T
A
A
D
---
G
P
---------------------
V
----
D
-
E
Y
M
L
P
F
E
E
E
I
-
G
Q
H
P
S
L
E
D
-----------------------------------------------------------
494
Blastp_CBE
37.21
35%
-12
- C1 -
-
3SOC
4
AVR2A_HUMAN
B:
[35-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
F
G
C
V
W
K
A
-
Q
L
-------
L
-
N
E
--
Y
-
V
A
V
K
-------
I
F
P
I
----
Q
D
K
Q
S
W
Q
N
E
Y
E
V
YS
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
-
A
-
E
K
R
G
T
SVDV
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
-
K
----------
A
------
N
---
V
---
V
S
W
N
E
L
C
H
I
A
E
T
M
A
------
R
G
L
A
Y
L
H
E
--
D
IPGLKDG
H
---
K
PAI
S
---
H
R
D
I
K
S
K
N
V
L
L
-----
K
N
N
L
--------
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
--
T
H
G
-
Q
V
G
--
T
R
R
Y
M
A
P
E
-
V
L
-
E
-
G
-
A
----
I
N
FQRDAF
L
-
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
--
R
-
C
T
A
A
D
---
G
P
---------------------
V
----
D
-
E
Y
M
L
P
F
E
E
E
I
-
G
Q
H
P
S
L
E
D
-----------------------------------------------------------
256
Blastp_CBE
36.84
37%
-62
- C1 -
-
3PPZ
1
CTR1_ARATH
A:
[44-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
------
G
A
G
S
F
G
T
V
H
R
A
-
E
W
-------
H
-
G
S
--
D
-
V
A
V
K
I
L
M
E
-----
A
E
----
R
V
-
N
E
F
L
R
E
V
A
I
--
M
K
R
L
R
H
P
N
I
V
L
F
M
G
-
A
-
V
T
Q
P
P
----
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
-
H
-
K
-
S
----
G
A
R
------
E
---
Q
---
L
D
E
R
R
R
L
S
M
A
Y
D
V
A
------
K
G
M
N
Y
L
H
N
--
R
-------
N
---
P
PI-
V
---
H
R
D
L
K
S
P
N
L
L
V
-----
D
K
K
Y
--------
T
V
K
V
C
D
F
G
L
S
R
L
K
A
S
F
-----
L
S
K
-
A
A
G
--
T
P
E
W
M
A
P
E
-
V
L
-
R
-
D
-
E
----
P
S
N-----
E
-
K
-
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
36.81
31%
-17
- C1 -
-
6PDJ
2
?
A:
[29-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
G
H
T
--
K
-
V
A
V
K
S
L
K
Q
-----
G
S
----
M
S
P
D
A
F
L
A
E
A
N
L
--
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
-
V
-
V
T
Q
-
E
----
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
-
K
-
T
-
P
----
S
G
I
------
K
-------
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
------
E
G
M
A
F
I
E
E
--
R
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
I
L
V
-----
S
D
T
L
--------
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
T
A
R
E
G
A
K
-
F
----
P
I
K
W
T
A
P
E
-
A
I
-
N
Y
G
-
T
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
------------
H
G
---------------------
R
----
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
------
R
M
-
V
-
R
P
-
D
-
N
C
P
-
E
-----
E
L
--
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
---
259
Blastp_CBE
36.59
37%
-62
- C1 -
-
3P86
1
CTR1_ARATH
A:
[44-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
------
G
A
G
S
F
G
T
V
H
R
A
-
E
W
-------
H
-
G
S
--
D
-
V
A
V
K
I
L
M
E
Q
-
D
F
H
A
E
----
R
V
-
N
E
F
L
R
E
V
A
I
--
M
K
R
L
R
H
P
N
I
V
L
F
M
G
-
A
-
V
T
Q
P
P
----
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
-
H
-
K
-
S
----
G
A
R
------
E
---
Q
---
L
D
E
R
R
R
L
S
M
A
Y
D
V
A
------
K
G
M
N
Y
L
H
N
--
R
-------
N
---
P
PI-
V
---
H
R
N
L
K
S
P
N
L
L
V
-----
D
K
K
Y
--------
T
V
K
V
C
D
F
--------------------
G
--
T
P
E
W
M
A
P
E
-
V
L
-
R
-
D
-
E
----
P
S
N-----
E
-
K
-
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
------------------------------------------------------------------------------------------------------------------------
497
Blastp_CBE
36.17
35%
-3
- C1 -
-
3Q4T
11
AVR2A_HUMAN
A:
[35-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
F
G
C
V
W
K
A
-
Q
L
-------
L
-
N
E
--
Y
-
V
A
V
K
-------
I
F
P
I
----
Q
D
K
Q
S
W
Q
N
E
Y
E
V
YS
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
-
A
-
E
K
R
G
T
SVDV
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
-
K
----------
A
------
N
---
V
---
V
S
W
N
E
L
C
H
I
A
E
T
M
A
------
R
G
L
A
Y
L
H
E
--
D
IPGLKDG
H
---
K
PAI
S
---
H
R
D
I
K
S
K
N
V
L
L
-----
K
N
N
L
--------
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
G
D
T
H
G
-
Q
V
G
--
T
R
R
Y
M
A
P
E
-
V
L
-
E
-
G
-
A
----
I
N
FQRDAF
L
-
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
--
R
-
C
T
A
A
D
---
G
P
---------------------
V
----
D
-
E
Y
M
L
P
F
E
E
E
I
-
G
Q
H
P
S
L
E
D
-----------------------------------------------------------
493
Blastp_CBE
36.16
35%
-11
- C1 -
-
4ASX
3
AVR2A_HUMAN
A:
[35-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
F
G
C
V
W
K
A
-
Q
L
-------
L
-
N
E
--
Y
-
V
A
V
K
-------
I
F
P
I
----
Q
D
K
Q
S
W
Q
N
E
Y
E
V
YS
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
-
A
-
E
K
R
G
T
SVDV
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
-
K
----------
A
------
N
---
V
---
V
S
W
N
E
L
C
H
I
A
E
T
M
A
------
R
G
L
A
Y
L
H
E
--
D
IPGLKDG
H
---
K
PAI
S
---
H
R
D
I
K
S
K
N
V
L
L
-----
K
N
N
L
--------
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
G
-
T
H
G
-
Q
V
G
--
T
R
R
Y
M
A
P
E
-
V
L
-
E
-
G
-
A
----
I
N
FQRDAF
L
-
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
--
R
-
C
T
A
A
D
---
G
P
---------------------
V
----
D
-
E
Y
M
L
P
F
E
E
E
I
-
G
Q
H
P
S
L
E
D
-----------------------------------------------------------
492
Blastp_CBE
35.81
35%
-4
- C1 -
-
4ASX
6
AVR2A_HUMAN
B:
[35-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
F
G
C
V
W
K
A
-
Q
L
-------
L
-
N
E
--
Y
-
V
A
V
K
-------
I
F
P
I
----
Q
D
K
Q
S
W
Q
N
E
Y
E
V
YS
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
-
A
-
E
K
R
G
T
SVDV
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
-
K
----------
A
------
N
---
V
---
V
S
W
N
E
L
C
H
I
A
E
T
M
A
------
R
G
L
A
Y
L
H
E
--
D
IPGLKDG
H
---
K
PAI
S
---
H
R
D
I
K
S
K
N
V
L
L
-----
K
N
N
L
--------
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
G
D
T
H
G
-
Q
V
G
--
T
R
R
Y
M
A
P
E
-
V
L
-
E
-
G
-
A
----
I
N
FQRDAF
L
-
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
--
R
-
C
T
A
A
D
---
G
P
---------------------
V
----
D
-
E
Y
M
L
P
F
E
E
E
I
-
G
Q
H
P
S
L
E
D
-----------------------------------------------------------
495
Blastp_CBE
35.77
35%
1
- C1 -
-
3SOC
7
AVR2A_HUMAN
A:
[35-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
F
G
C
V
W
K
A
-
Q
L
-------
L
-
N
E
--
Y
-
V
A
V
K
-------
I
F
P
I
----
Q
D
K
Q
S
W
Q
N
E
Y
E
V
YS
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
-
A
-
E
K
R
G
T
SVDV
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
-
K
----------
A
------
N
---
V
---
V
S
W
N
E
L
C
H
I
A
E
T
M
A
------
R
G
L
A
Y
L
H
E
--
D
IPGLKDG
H
---
K
PAI
S
---
H
R
D
I
K
S
K
N
V
L
L
-----
K
N
N
L
--------
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
G
D
T
H
G
-
Q
V
G
--
T
R
R
Y
M
A
P
E
-
V
L
-
E
-
G
-
A
----
I
N
FQRDAF
L
-
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
--
R
-
C
T
A
A
D
---
G
P
---------------------
V
----
D
-
E
Y
M
L
P
F
E
E
E
I
-
G
Q
H
P
S
L
E
D
-----------------------------------------------------------
469
Blastp_CBE
34.56
33%
-20
- C1 -
-
4YZM
1
B:
[26-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
------
G
K
G
G
F
G
L
V
H
K
G
-
R
L
VK-----
D
-
K
S
--
V
-
V
A
I
K
S
L
I
-
L
----
G
E
TEMI
E
K
F
Q
E
F
Q
R
E
V
F
I
--
M
S
N
L
N
H
P
N
I
V
K
L
Y
G
-
L
-
M
H
N
P
P
----
R
M
V
M
E
L
V
--
P
C
G
D
L
Y
H
R
L
-----
L
----
D
K
A
------
H
---
P
---
I
K
W
S
V
K
L
R
L
M
L
D
I
A
------
L
G
I
E
Y
M
Q
N
--
Q
-------
N
---
P
PI-
V
---
H
R
D
L
R
S
P
N
I
L
L
QSLDE
N
A
P
V
--------
C
A
K
V
A
D
F
G
L
S
Q
--------------
L
L
G
--
N
F
Q
W
M
A
P
E
-
T
I
-
G
-
A
--ES--
Y
T
------
E
-
K
-
A
D
T
Y
S
F
A
M
I
L
Y
T
I
L
T
--
G
-
E
G
P
F
D
---
E
Y
----------------------------------------------------------------------------------------------------------
470
Blastp_CBE
33.61
33%
-23
- C1 -
-
4YZM
1
ROCO4_DICDI
A:
[26-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
------
G
K
G
G
F
G
L
V
H
K
G
-
R
L
VK-----
D
-
K
S
--
V
-
V
A
I
K
S
L
I
-
L
------TEMI
E
K
F
Q
E
F
Q
R
E
V
F
I
--
M
S
N
L
N
H
P
N
I
V
K
L
Y
G
-
L
-
M
H
N
P
P
----
R
M
V
M
E
L
V
--
P
C
G
D
L
Y
H
R
L
-----
L
----
D
K
A
------
H
---
P
---
I
K
W
S
V
K
L
R
L
M
L
D
I
A
------
L
G
I
E
Y
M
Q
N
--
Q
-------
N
---
P
PI-
V
---
H
R
D
L
R
S
P
N
I
L
L
QSLDE
N
A
P
V
--------
C
A
K
V
A
D
F
G
L
S
Q
Q
--------------
L
G
--
N
F
Q
W
M
A
P
E
-
T
I
-
G
-
A
-
E
E---
Y
T
------
E
-
K
-
A
D
T
Y
S
F
A
M
I
L
Y
T
I
L
T
--
G
-
E
G
P
F
D
---
E
Y
----------------------------------------------------------------------------------------------------------
468
Blastp_CBE
33.59
33%
-12
- C1 -
-
4YZN
1
A:
[26-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
------
G
K
G
G
F
G
L
V
H
K
G
-
R
L
VK-----
D
-
K
S
--
V
-
V
A
I
K
S
L
I
-
L
-----
E
TEMI
E
K
F
Q
E
F
Q
R
E
V
F
I
--
M
S
N
L
N
H
P
N
I
V
K
L
Y
G
-
L
-
M
H
N
P
P
----
R
M
V
M
E
L
V
--
P
C
G
D
L
Y
H
R
L
-----
L
----
D
K
A
------
H
---
P
---
I
K
W
S
V
K
L
R
L
M
L
D
I
A
------
L
G
I
E
Y
M
Q
N
--
Q
-------
N
---
P
PI-
V
---
H
R
D
L
R
S
P
N
I
L
L
QSLDE
N
A
P
V
--------
C
A
K
V
A
D
F
G
L
S
Q
Q
S
-----
V
H
S
V
S
G
-
L
L
G
--
N
F
Q
W
M
A
P
E
-
T
I
-
G
-
A
-
E
EES-
Y
T
------
E
-
K
-
A
D
T
Y
S
F
A
M
I
L
Y
T
I
L
T
--
G
-
E
G
P
F
D
---
E
Y
----------------------------------------------------------------------------------------------------------
168
Blastp_CBE
33.23
35%
-8
- C1 -
-
4Q5J
1
B:
[32-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
F
A
D
L
L
Q
A
T
N
G
F
H
N
D
S
L
------
I
------
G
S
G
G
F
G
D
V
Y
K
A
-
I
L
K------
D
-
G
S
--
A
-
V
A
I
K
K
L
I
H
-------------
D
R
E
F
A
E
E
M
-
T
--
I
G
K
I
K
H
R
N
L
V
P
L
L
G
-
Y
-
C
K
V
G
D
----
E
R
L
L
V
Y
E
F
-
K
Y
G
S
L
E
D
V
L
H
D
-
P
-----------------------
L
N
W
S
T
R
R
K
I
A
I
G
S
A
------
R
G
L
A
F
L
H
H
--
N
CSP----
H
---
I
---
I
---
H
R
D
-
K
S
S
N
V
L
L
-----
D
E
N
L
--------
E
A
R
V
S
D
F
G
-
A
R
L
S
---
A
D
H
L
V
T
M
D
-
L
A
G
--
T
P
G
Y
V
P
P
E
-
Y
Y
-
Q
-
F
-
R
----
C
S
------
T
-
K
-
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
--
G
-
K
R
P
T
D
SP-
D
F
---------------------
G
----
D
N
N
L
V
G
W
V
K
Q
H
---
A
K
L
R
I
S
D
V
F
D
P
E
L
-
K
-
E
D
-
P
-
A
L
E
I
E
-----
L
L
QH
L
K
V
A
V
A
C
L
D
D
R
A
W
R
R
P
---
T
V
Q
V
A
F
K
E
I
Q
A
G
489
Blastp_CBE
33.08
35%
-76
- C1 -
-
3DTC
1
M3K9_HUMAN
A:
[15-210]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
------
G
I
G
G
F
G
K
V
Y
R
A
-
F
W
-------
I
-
G
D
--
E
-
V
A
V
K
A
A
--------------
T
I
E
N
V
R
Q
E
A
K
L
--
F
A
M
L
K
H
P
N
I
I
A
L
R
G
-
V
-
C
L
K
E
------
L
C
L
V
M
E
F
A
R
G
G
P
-
L
N
R
V
-
L
-
S
-
G
----
K
R
I
------
P
---
P
DIL
V
N
W
A
V
Q
I
------
A
------
R
G
M
N
Y
L
H
D
--
E
-------
A
IVP
I
---
I
---
H
R
D
L
K
S
S
N
I
L
I
-----
L
Q
K
V
ENGDLSNK
I
L
K
I
T
D
F
G
L
------------------
G
--
A
Y
A
W
M
A
P
E
-
V
I
-
R
-
A
-
S
----
M
F
------
S
-
K
G
S
D
V
W
S
Y
G
V
L
L
W
E
L
L
T
--
G
---------------------------------------------------------------------------------------------------------------------
460
Blastp_CBE
33.01
32%
-13
- C1 -
-
4F1T
2
A:
[26-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
------
G
K
G
G
F
G
L
V
H
K
G
-
R
L
VK-----
D
-
K
S
--
V
-
V
A
I
K
S
L
I
--------TEMI
E
K
F
Q
E
F
Q
R
E
V
F
I
--
M
S
N
L
N
H
P
N
I
V
K
L
Y
G
-
L
-
M
H
N
P
P
----
R
M
V
M
E
F
V
--
P
C
G
D
L
Y
H
R
L
-----
L
----
D
K
A
------
H
---
P
---
I
K
W
S
V
K
L
R
L
M
L
D
I
A
------
L
G
I
E
Y
M
Q
N
--
Q
-------
N
---
P
PI-
V
---
H
R
D
L
R
S
P
N
I
F
L
QSLDE
N
A
P
V
--------
C
A
K
V
A
D
F
G
L
S
Q
Q
S
-----
V
H
S
V
S
G
-
L
L
G
--
N
F
Q
W
M
A
P
E
-
T
I
-
G
-
A
-
E
EES-
Y
T
------
E
-
K
-
A
D
T
Y
S
F
A
M
I
L
Y
T
I
L
T
--
G
-
E
G
P
F
D
---
E
Y
----------------------------------------------------------------------------------------------------------
169
Blastp_CBE
32.90
35%
-1
- C1 -
-
4Q5J
1
BRI1_ARATH
A:
[32-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
F
A
D
L
L
Q
A
T
N
G
F
H
N
D
S
L
------
I
------
G
S
G
G
F
G
D
V
Y
K
A
-
I
L
K------
D
-
G
S
--
A
-
V
A
I
K
K
L
I
H
V
----
S
-------
D
R
E
F
A
E
E
M
-
T
--
I
G
K
I
K
H
R
N
L
V
P
L
L
G
-
Y
-
C
K
V
G
D
----
E
R
L
L
V
Y
E
F
-
K
Y
G
S
L
E
D
V
L
H
D
--------------------------
N
W
S
T
R
R
K
I
A
I
G
S
A
------
R
G
L
A
F
L
H
H
--
N
CSP----
H
---
I
---
I
---
H
R
D
-
K
S
S
N
V
L
L
-----
D
E
N
L
--------
E
A
R
V
S
D
F
G
-
A
R
L
S
---
A
D
H
L
V
T
M
D
-
L
A
G
--
T
P
G
Y
V
P
P
E
-
Y
Y
-
Q
-
F
-
R
----
C
S
------
T
-
K
-
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
--
G
-
K
R
P
T
D
SP-
D
F
---------------------
G
----
D
N
N
L
V
G
W
V
K
Q
H
---
A
K
L
R
I
S
D
V
F
D
P
E
L
-
K
-
E
D
-
P
-
A
L
E
I
E
-----
L
L
QH
L
K
V
A
V
A
C
L
D
D
R
A
W
R
R
P
---
T
V
Q
V
A
F
K
E
I
Q
A
G
446
Blastp_CBE
32.22
34%
-16
- C1 -
-
4UYA
1
M3K21_HUMAN
A:
[19-234]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
H
V
A
F
E
R
L
ELKELI
G
A
---
G
Q
V
Y
R
A
-
T
W
-------
Q
-
G
Q
--
E
-
V
A
V
K
----------
A
----
A
A
A
E
S
V
R
R
E
A
R
L
--
F
A
M
L
R
H
P
N
I
I
E
L
R
G
-
V
-
C
L
Q
Q
P
----
H
L
C
L
V
L
E
F
A
R
G
G
A
-
L
N
R
A
-
L
-
A
-
G
----
R
R
I
------
P
---
P
------
H
V
L
V
N
W
A
V
Q
I
A
------
R
G
M
L
Y
L
H
E
--
E
-------
A
---
F
---
V
PIL
H
R
D
L
K
S
S
N
I
L
L
-----
L
E
K
I
EHDICNK-
T
L
K
I
T
D
F
--------------------
G
--
A
Y
A
W
M
A
P
E
-
V
I
-
K
-
S
-
S
----
L
F
------
S
-
K
G
S
D
I
W
S
Y
G
V
L
L
W
E
L
L
T
--
G
---------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
31.76
31%
0
- C1 -
-
4FIE
1
PAK4_HUMAN
A:
[46-345]
--------------------------------------------------------------------------------------------------------------------------------------------------
P
P
G
P
R
S
----
P
Q
R
V
S
H
E
Q
F
R
A
----
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
------
G
E
G
S
T
G
I
V
C
I
A
-
T
V
-------
R
-
S
S
GK
L
-
V
A
V
K
K
M
----
D
L
R
K
Q
----
Q
R
R
E
L
L
F
N
E
V
V
I
--
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
-
S
-
Y
L
V
G
D
----
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
----------------------------
H
T
R
M
N
E
E
Q
I
A
A
VCLAVL
Q
A
L
S
V
L
H
A
--
Q
-------
G
---
V
---
I
---
H
R
D
I
K
S
D
S
I
L
L
-----
T
H
D
G
--------
R
V
K
L
S
D
F
G
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
--
T
P
Y
W
M
A
P
E
-
L
I
S
R
-
L
-
P
----
Y
G
------
P
-
E
-
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
--
G
-
E
P
------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
31.68
37%
-68
- C1 -
-
3A4O
1
X:
[20-206]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
------
G
A
G
Q
F
G
E
V
W
M
G
-
Y
Y
-------
N
-
N
S
--
T
K
V
A
V
K
T
L
K
P
G
T
M
S
V
---------
Q
A
F
L
E
E
A
N
L
--
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
-
V
-
V
T
R
E
E
----
P
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
-
K
-
S
-
D
----
E
G
G
------
K
---
V
---
L
L
P
K
L
I
D
F
S
A
Q
-
I
A
------
E
G
M
A
Y
I
E
R
--
K
-------
N
---
Y
---
I
---
H
R
D
L
R
A
A
N
V
L
V
-----
S
E
S
L
--------
M
C
K
I
A
D
F
G
L
A
R
V
---------
E
G
A
-
K
F
---
P
I
K
W
T
A
P
E
-
A
I
-
N
F
G
-
C
----
F
T
------
I
-
K
-
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
31.64
31%
1
- C1 -
-
4FIE
1
PAK4_HUMAN
B:
[46-345]
--------------------------------------------------------------------------------------------------------------------------------------------------
P
P
G
P
R
S
----
P
Q
R
V
S
H
E
Q
F
R
A
----
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
------
G
E
G
S
T
G
I
V
C
I
A
-
T
V
-------
R
-
S
S
GK
L
-
V
A
V
K
K
M
----
D
L
R
K
Q
----
Q
R
R
E
L
L
F
N
E
V
V
I
--
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
-
S
-
Y
L
V
G
D
----
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
----------------------------
H
T
R
M
N
E
E
Q
I
A
A
VCLAVL
Q
A
L
S
V
L
H
A
--
Q
-------
G
---
V
---
I
---
H
R
D
I
K
S
D
S
I
L
L
-----
T
H
D
G
--------
R
V
K
L
S
D
F
G
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
--
T
P
Y
W
M
A
P
E
-
L
I
S
R
-
L
-
P
----
Y
G
------
P
-
E
-
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
--
G
-
E
P
------------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
30.25
31%
-8
- C1 -
-
5VEF
1
?
A:
[28-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
----
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
------
G
E
G
S
T
G
I
V
C
I
A
-
T
V
-------
R
-
S
S
GK
L
-
V
A
V
K
K
M
----
D
L
R
K
Q
----
Q
R
R
E
L
L
F
N
E
V
V
I
--
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
-
S
-
Y
L
V
G
D
----
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
----------------------------
H
T
R
M
N
E
E
Q
I
A
A
VCLAVL
Q
A
L
S
V
L
H
A
--
Q
-------
G
---
V
---
I
---
H
R
D
I
K
S
D
S
I
L
L
-----
T
H
D
G
--------
R
V
K
L
S
D
F
G
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
--
T
P
Y
W
M
A
P
E
-
L
I
S
R
-
L
-
P
----
Y
G
------
P
-
E
-
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
--
G
-
E
P
------------------------------------------------------------------------------------------------------------------
456
Blastp_CBE
30.20
31%
-7
- C1 -
-
4FIG
1
?
B:
[53-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
----
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
------
G
E
G
S
T
G
I
V
C
I
A
-
T
V
-------
R
-
S
S
GK
L
-
V
A
V
K
K
M
----
D
L
R
K
Q
----
Q
R
R
E
L
L
F
N
E
V
V
I
--
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
-
S
-
Y
L
V
G
D
----
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
----------------------------
H
T
R
M
N
E
E
Q
I
A
A
VCLAVL
Q
A
L
S
V
L
H
A
--
Q
-------
G
---
V
---
I
---
H
R
D
I
K
S
D
S
I
L
L
-----
T
H
D
G
--------
R
V
K
L
S
D
F
G
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
--
T
P
Y
W
M
A
P
E
-
L
I
S
R
-
L
-
P
----
Y
G
------
P
-
E
-
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
--
G
-
E
P
------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
29.95
31%
-11
- C1 -
-
5VEE
1
PAK4_HUMAN
A:
[28-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
----
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
------
G
E
G
S
T
G
I
V
C
I
A
-
T
V
-------
R
-
S
S
GK
L
-
V
A
V
K
K
M
----
D
L
R
K
Q
----
Q
R
R
E
L
L
F
N
E
V
V
I
--
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
-
S
-
Y
L
V
G
D
----
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
----------------------------
H
T
R
M
N
E
E
Q
I
A
A
VCLAVL
Q
A
L
S
V
L
H
A
--
Q
-------
G
---
V
---
I
---
H
R
D
I
K
S
D
S
I
L
L
-----
T
H
D
G
--------
R
V
K
L
S
D
F
G
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
--
T
P
Y
W
M
A
P
E
-
L
I
S
R
-
L
-
P
----
Y
G
------
P
-
E
-
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
--
G
-
E
P
------------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
29.89
31%
-9
- C1 -
-
4FIF
1
PAK4_HUMAN
A:
[51-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
R
V
S
H
E
Q
F
R
A
----
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
------
G
E
G
S
T
G
I
V
C
I
A
-
T
V
-------
R
-
S
S
GK
L
-
V
A
V
K
K
M
----
D
L
R
K
Q
----
Q
R
R
E
L
L
F
N
E
V
V
I
--
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
-
S
-
Y
L
V
G
D
----
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
----------------------------
H
T
R
M
N
E
E
Q
I
A
A
VCLAVL
Q
A
L
S
V
L
H
A
--
Q
-------
G
---
V
---
I
---
H
R
D
I
K
S
D
S
I
L
L
-----
T
H
D
G
--------
R
V
K
L
S
D
F
G
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
--
T
P
Y
W
M
A
P
E
-
L
I
S
R
-
L
-
P
----
Y
G
------
P
-
E
-
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
--
G
-
E
P
------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
29.75
31%
-11
- C1 -
-
4JDI
1
A:
[55-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
----
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
------
G
E
G
S
T
G
I
V
C
I
A
-
T
V
-------
R
-
S
S
GK
L
-
V
A
V
K
K
M
----
D
L
R
K
Q
----
Q
R
R
E
L
L
F
N
E
V
V
I
--
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
-
S
-
Y
L
V
G
D
----
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
----------------------------
H
T
R
M
N
E
E
Q
I
A
A
VCLAVL
Q
A
L
S
V
L
H
A
--
Q
-------
G
---
V
---
I
---
H
R
D
I
K
S
D
S
I
L
L
-----
T
H
D
G
--------
R
V
K
L
S
D
F
G
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
--
T
P
Y
W
M
A
P
E
-
L
I
S
R
-
L
-
P
----
Y
G
------
P
-
E
-
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
--
G
-
E
P
------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
29.74
31%
-12
- C1 -
-
5UPK
1
?
B:
[55-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
----
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
------
G
E
G
S
T
G
I
V
C
I
A
-
T
V
-------
R
-
S
S
GK
L
-
V
A
V
K
K
M
----
D
L
R
K
Q
----
Q
R
R
E
L
L
F
N
E
V
V
I
--
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
-
S
-
Y
L
V
G
D
----
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
----------------------------
H
T
R
M
N
E
E
Q
I
A
A
VCLAVL
Q
A
L
S
V
L
H
A
--
Q
-------
G
---
V
---
I
---
H
R
D
I
K
S
D
S
I
L
L
-----
T
H
D
G
--------
R
V
K
L
S
D
F
G
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
--
T
P
Y
W
M
A
P
E
-
L
I
S
R
-
L
-
P
----
Y
G
------
P
-
E
-
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
--
G
-
E
P
------------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
29.61
31%
-11
- C1 -
-
2Q0N
6
A:
[8-223]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
----
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
------
G
E
G
S
T
G
I
V
C
I
A
-
T
V
-------
R
-
S
S
GK
L
-
V
A
V
K
K
M
----
D
L
R
K
Q
----
Q
R
R
E
L
L
F
N
E
V
V
I
--
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
-
S
-
Y
L
V
G
D
----
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
----------------------------
H
T
R
M
N
E
E
Q
I
A
A
VCLAVL
Q
A
L
S
V
L
H
A
--
Q
-------
G
---
V
---
I
---
H
R
D
I
K
S
D
S
I
L
L
-----
T
H
D
G
--------
R
V
K
L
S
D
F
G
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
--
T
P
Y
W
M
A
P
E
-
L
I
S
R
-
L
-
P
----
Y
G
------
P
-
E
-
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
--
G
-
E
P
------------------------------------------------------------------------------------------------------------------
499
Blastp_CBE
29.38
33%
11
- C1 -
-
2XIK
2
STK25_HUMAN
A:
[25-214]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
I
------
G
K
G
S
F
G
E
V
Y
K
G
-
I
D
-------
N
-
H
T
KE
V
-
V
A
I
K
I
I
D
L
E
E
A
E
-
E
I
----
E
D
I
Q
Q
---
E
I
T
V
--
L
S
Q
C
D
S
P
Y
I
T
R
Y
F
G
-
S
-
Y
L
K
S
T
----
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
-
K
----------
P
------
G
---
P
---
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
------
K
G
L
D
Y
L
H
S
--
E
-------
R
---
K
---
I
---
H
R
D
I
K
A
A
N
V
L
L
-----
S
E
Q
G
--------
D
V
K
L
A
D
F
G
V
A
---
G
Q
L
T
D
T
Q
I
K
R
N
-
F
V
G
--
T
P
F
W
M
A
P
E
-
V
I
-
K
-
Q
-
S
----
A
Y
------
D
F
K
-
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
--
G
-
E
P
------------------------------------------------------------------------------------------------------------------
161
Blastp_CBE
29.38
35%
19
- C1 -
-
3UIM
1
BAK1_ARATH
A:
[15-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
L
K
R
F
S
L
R
E
L
Q
V
A
S
D
N
F
N
K
-------
N
I
L
------
G
R
G
G
F
G
K
V
Y
K
G
-
R
L
-------
A
-
D
G
--
L
-
V
A
V
K
R
L
K
---
E
E
R
---------
L
Q
F
Q
T
E
V
E
M
--
I
S
M
A
V
H
R
N
L
L
R
L
R
G
-
F
-
C
M
T
P
T
----
E
R
L
L
V
Y
P
Y
M
A
N
G
S
V
A
----
S
-
C
-
L
RERP
E
S
Q
------
P
---
P
---
L
D
W
P
K
R
Q
R
I
A
L
G
S
A
------
R
G
L
A
Y
L
H
D
--
H
CDP----
K
---
I
---
I
---
H
R
D
V
K
A
A
N
I
L
L
-----
D
E
E
F
--------
E
A
V
V
G
D
F
G
L
A
K
L
M
D
-
Y
K
D
H
V
A
V
R
G
-
I
------
G
H
I
A
P
E
-
Y
L
-
S
T
G
-
K
----
S
S
------
E
-
K
-
T
D
V
F
G
Y
G
V
M
L
L
E
L
I
T
--
G
-
Q
R
A
F
D
---
L
A
---------------------
R
LAND
D
D
V
M
L
L
D
W
V
K
G
L
L
-
K
E
K
K
L
E
A
L
V
D
V
D
L
Q
G
-
N
Y
-
K
-
D
E
E
V
E
-----
Q
L
--
I
Q
V
A
L
L
C
T
Q
S
S
P
M
E
R
P
K
M
S
E
V
V
R
M
L
E
-----
481
Blastp_CBE
29.35
31%
-6
- C1 -
-
2CDZ
1
A:
[11-225]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
E
Q
F
R
A
----
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
------
G
E
G
S
T
G
I
V
C
I
A
-
T
V
-------
R
---GK
L
-
V
A
V
K
K
M
----
D
L
R
K
Q
----
Q
R
R
E
L
L
F
N
E
V
V
I
--
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
-
S
-
Y
L
V
G
D
----
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
----------------------------
H
T
R
M
N
E
E
Q
I
A
A
VCLAVL
Q
A
L
S
V
L
H
A
--
Q
-------
G
---
V
---
I
---
H
R
D
I
K
S
D
S
I
L
L
-----
T
H
D
G
--------
R
V
K
L
S
D
F
G
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
--
T
P
Y
W
M
A
P
E
-
L
I
S
R
-
L
-
P
----
Y
G
------
P
-
E
-
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
--
G
-
E
P
------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
28.70
31%
-7
- C1 -
-
4FIF
1
B:
[52-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
V
S
H
E
Q
F
R
A
----
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
------
G
E
G
S
T
G
I
V
C
I
A
-
T
V
-------
R
-
S
S
GK
L
-
V
A
V
K
K
M
----
D
L
R
K
Q
----
Q
R
R
E
L
L
F
N
E
V
V
I
--
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
-
S
-
Y
L
V
G
D
----
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
----------------------------
H
T
R
M
N
E
E
Q
I
A
A
VCLAVL
Q
A
L
S
V
L
H
A
--
Q
-------
G
---
V
---
I
---
H
R
D
I
K
S
D
S
I
L
L
-----
T
H
D
G
--------
R
V
K
L
S
D
F
G
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
--
T
P
Y
W
M
A
P
E
-
L
I
S
R
-
L
-
P
----
Y
G
------
P
-
E
-
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
--
G
-
E
P
------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
28.64
31%
-9
- C1 -
-
2J0I
4
A:
[12-225]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
----
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
------
G
E
G
S
T
G
I
V
C
I
A
-
T
V
-------
R
-
S
S
GK
L
-
V
A
V
K
K
M
----
D
L
R
K
Q
----
Q
R
R
E
L
L
F
N
E
V
V
I
--
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
-
S
-
Y
L
V
G
D
----
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
----------------------------
H
T
R
M
N
E
E
Q
I
A
A
VCLAVL
Q
A
L
S
V
L
H
A
--
Q
-------
G
---
V
---
I
---
H
R
D
I
K
S
D
S
I
L
L
-----
T
H
D
G
--------
R
V
K
L
S
D
F
G
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
--
T
P
Y
W
M
A
P
E
-
L
I
S
R
-
L
-
P
----
Y
G
------
P
-
E
-
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
--
G
-
E
P
------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
28.62
31%
-7
- C1 -
-
4FIG
1
?
A:
[53-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
----
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
------
G
E
G
S
T
G
I
V
C
I
A
-
T
V
-------
R
-
S
S
GK
L
-
V
A
V
K
K
M
----
D
L
R
K
Q
----
Q
R
R
E
L
L
F
N
E
V
V
I
--
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
-
S
-
Y
L
V
G
D
----
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
----------------------------
H
T
R
M
N
E
E
Q
I
A
A
VCLAVL
Q
A
L
S
V
L
H
A
--
Q
-------
G
---
V
---
I
---
H
R
D
I
K
S
D
S
I
L
L
-----
T
H
D
G
--------
R
V
K
L
S
D
F
G
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
--
T
P
Y
W
M
A
P
E
-
L
I
S
R
-
L
-
P
----
Y
G
------
P
-
E
-
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
--
G
-
E
P
------------------------------------------------------------------------------------------------------------------
449
Blastp_CBE
28.31
31%
-9
- C1 -
-
5VED
1
A:
[28-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
----
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
------
G
E
G
S
T
G
I
V
C
I
A
-
T
V
-------
R
-
S
S
GK
L
-
V
A
V
K
K
M
----
D
L
R
K
Q
----
Q
R
R
E
L
L
F
N
E
V
V
I
--
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
-
S
-
Y
L
V
G
D
----
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
-
T
----------------------------
H
T
R
M
N
E
E
Q
I
A
A
VCLAVL
Q
A
L
S
V
L
H
A
--
Q
-------
G
---
V
---
I
---
H
R
D
I
K
S
D
S
I
L
L
-----
T
H
D
G
--------
R
V
K
L
S
D
F
G
F
C
---
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
--
T
P
Y
W
M
A
P
E
-
L
I
S
R
-
L
-
P
----
Y
G
------
P
-
E
-
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
--
G
-
E
P
------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
27.16
31%
-4
- C1 -
-
5FD2
1
B:
[23-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
R
I
------
G
S
G
S
F
G
T
V
Y
K
G
-
K
W
-------
H
-
G
D
----
V
A
V
K
M
L
N
-----------------
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
-
S
T
K
-
P
----
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
-
H
-
I
-
I
----
E
T
K
------
F
---
E
---
M
I
--
K
L
I
D
I
A
R
Q
T
A
------
Q
G
M
D
Y
L
H
A
--
K
-------
S
---
I
---
I
---
H
R
D
L
K
S
N
N
I
F
L
-----
H
E
D
L
--------
T
V
K
I
G
D
F
G
L
------------------
G
--
S
I
L
W
M
A
P
E
-
V
I
-
R
-
M
-
Q
DKNP
Y
S
------
F
-
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
--
G
Q
L
P
Y
S
N
---
I
N
---------------------
N
----
R
D
Q
I
I
F
M
V
G
----------
R
G
Y
L
S
P
D
L
-
S
-
K
V
-
R
-
S
N
C
P
K
-----
A
M
--
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
---------------
-
* C *
-
-
:
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------