@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KCC1G_HUMAN: (2020-09-11 )
MGRKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFAKSKWRQAFNAAAVVHHMRKLHMNLHSPGVRPEVENRPPETQASETSRPSSPEITITEAPVLDHSVALPALTQLPCQHGRRPTAPGGRSLNCLVNGSLHISSSLVPMHQGSLAAGPCGCCSSCLNIGSKGKSSYCSEPTLLKKANKKQNFKSEVMVPVKASGSSHCRAGQTGVCLIM
Atome Classification :
(318 SA)
.........10..--.--.....20..-.....---.30.......-.40........50...----------.-----.---..------.60-------..----.---.-----..---.---..70....---.-.-.-------.80........90.----.......100.......110-.----.-.....120.......130.......140.......150..-.-..---..-160......---.-170.--.----..-.-..--..-180.......190-----.------.---..---.-.-.-.-200.......210.......220-.---.----...-------.----------...230.......240..-.....250.......260.......270--.......---..280--.....-.-.290..-.....-300.......310.......320-.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGRKE
E
D
D
C
S
S
W
K
--
K
--
Q
TTN
I
R
K
T
F
-
I
F
M
E
V
---LGSG
A
F
S
E
V
F
-
L
V
K
Q
R
LTG
K
L
F
A
L
K
C
I
----------K-----K---SP------AF--------RD----S---
S
-----
L
E
---
N
---
E
I
A
V
L
K
K
I---K-H-E-------N
I
V
T
L
E
D
I
Y
ESTT
H
----
Y
Y
L
V
M
Q
L
VSG
G
E
L
F
D
R
I
L
ER-G----V-YTE
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
ENG
I
V
HRDLKPE
N
L
L
Y
LTP-E-EN---
S
K
-
I
M
I
T
DFGL
S
---
K
-
M
--
E
--Q----NG-
I
-
M
S--TA-CGTPGYV
A
P
E
V
L
------A------Q---KP---Y-S-K-A-
V
D
C
W
S
I
G
V
I
T
Y
I
L
LCGYPP
F
Y
---
E
---
E
----
T
E
S
-------
K
----------
L
F
E
K
I
K
E
G
Y
Y
EFESP
F
W
D
-
D
I
S
E
S
A
K
D
F
I
C
H
L
L
EKDPNER
Y
T
C
E
K
----
A
LSHPWI---DGNTA--LHRDI-Y-PS
V
S
L
Q
-
I
Q
K
N
F
-
A
K
S
K
W
R
Q
A
F
N
A
A
A
V
V
H
H
M
R
K
L
H
M
-NLHSPGVRPEVENRPPETQASETSRPSSP
E
I
T
I
TEAPVLDHSVA
L
P
A
L
T
QL
P
C
QHGRRPTAPGG
R
S
L
N
C
L
V
NG
S
L
H
I
SS
S
L
VPMHQGSLAAG
P
C
G
C
C
S
S
C
L
NIGSKGKSSYCSE
P
T
L
L
K
KANKKQNFKSE
V
M
V
P
V
KASGSSHCRAGQ
T
G
V
C
L
IM
583
HHSearch
90.13
100%
-123
- C3 -
-
2JAM
3
KCC1G_HUMAN
B:
[4-289]
-------------------
T
T
N
I
R
K
T
F
-
I
F
M
E
V
---
L
G
S
G
A
F
S
E
V
F
-
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
----------
K
-----
K
---------------------------
S
---
S
-----
L
E
---
N
---
E
I
A
V
L
K
K
I
---
K
-
H
-
E
-------
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
----
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
-
G
----
V
-
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
-
E
-
E
N
---
S
K
-
I
M
I
T
D
F
G
L
S
---
K
-
M
--
E
--
Q
----
N
G
-
I
-
M
S
--
T
A
-
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
---
K
P
---
Y
-
S
-
K
-
A
-
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
---
E
---
E
----
T
E
S
-------
K
----------
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
-
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
----
A
L
S
H
P
W
I
---
D
G
N
T
A
--
L
H
R
D
I
-
Y
-
P
S
V
S
L
Q
-
I
Q
K
N
F
-
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
90.13
100%
-123
- C3 -
-
2JAM
3
KCC1G_HUMAN
B:
[4-289]
-------------------
T
T
N
I
R
K
T
F
-
I
F
M
E
V
---
L
G
S
G
A
F
S
E
V
F
-
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
----------
K
-----
K
---------------------------
S
---
S
-----
L
E
---
N
---
E
I
A
V
L
K
K
I
---
K
-
H
-
E
-------
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
----
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
-
G
----
V
-
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
-
E
-
E
N
---
S
K
-
I
M
I
T
D
F
G
L
S
---
K
-
M
--
E
--
Q
----
N
G
-
I
-
M
S
--
T
A
-
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
---
K
P
---
Y
-
S
-
K
-
A
-
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
---
E
---
E
----
T
E
S
-------
K
----------
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
-
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
----
A
L
S
H
P
W
I
---
D
G
N
T
A
--
L
H
R
D
I
-
Y
-
P
S
V
S
L
Q
-
I
Q
K
N
F
-
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
89.85
100%
-124
- C3 -
-
2JAM
3
KCC1G_HUMAN
A:
[6-290]
---------------------
N
I
R
K
T
F
-
I
F
M
E
V
---
L
G
S
G
A
F
S
E
V
F
-
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
----------
K
-----
K
---------------------------
S
---
S
-----
L
E
---
N
---
E
I
A
V
L
K
K
I
---
K
-
H
-
E
-------
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
----
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
-
G
----
V
-
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
-
E
-
E
N
---
S
K
-
I
M
I
T
D
F
G
L
S
---
K
-
M
--
E
--
Q
----
N
G
-
I
-
M
S
--
T
A
-
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
---
K
P
---
Y
-
S
-
K
-
A
-
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
---
E
---
E
----
T
E
S
-------
K
----------
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
-
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
----
A
L
S
H
P
W
I
---
D
G
N
T
A
--
L
H
R
D
I
-
Y
-
P
S
V
S
L
Q
-
I
Q
K
N
F
-
A
K
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
80.12
75%
-48
- C3 -
-
6T6F
1
?
A:
[5-317]
-----------
W
K
--
K
--
Q
A
E
D
I
K
K
I
F
-
E
F
K
E
T
---
L
G
T
G
A
F
S
E
V
V
-
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P---------
K
-----
K
---
A
L
------
K
G
--------
K
E
----
S
---
S
-----
I
E
---
N
---
E
I
A
V
L
R
K
I
---
K
-
H
-
E
-------
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
----
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
-
G
----
F
-
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
Q
-
D
-
E
E
---
S
K
-
I
M
I
S
D
F
G
L
S
-------------------------------
P
G
Y
V
A
P
E
V
L
------
A
------
Q
---
K
P
---
Y
-
S
-
K
-
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
---
E
----
N
D
S
-------
K
----------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
----
A
A
R
H
P
W
I
---
A
G
D
T
A
--
L
N
K
N
I
-
H
-
E
S
V
S
A
Q
-
I
R
K
N
F
-
A
K
---------------
M
R
K
L
H
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
78.91
75%
-49
- C3 -
-
6T6F
1
?
B:
[5-317]
-----------
W
K
--
K
--
Q
A
E
D
I
K
K
I
F
-
E
F
K
E
T
---
L
G
T
G
A
F
S
E
V
V
-
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P---------
K
-----
K
---
A
L
------
K
G
--------
K
E
----
S
---
S
-----
I
E
---
N
---
E
I
A
V
L
R
K
I
---
K
-
H
-
E
-------
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
----
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
-
G
----
F
-
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
Q
-
D
-
E
E
---
S
K
-
I
M
I
S
D
F
G
---------------------------------
P
G
Y
V
A
P
E
V
L
------
A
------
Q
---
K
P
---
Y
-
S
-
K
-
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
---
E
----
N
D
S
-------
K
----------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
----
A
A
R
H
P
W
I
---
A
G
D
T
A
--
L
N
K
N
I
-
H
-
E
S
V
S
A
Q
-
I
R
K
N
F
-
A
K
---------------
M
R
K
L
H
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
77.92
73%
-52
- C3 -
-
2JC6
1
KCC1D_HUMAN
A:
[12-314]
----------
S
W
K
--
K
--
Q
A
E
D
I
K
K
I
F
-
E
F
K
E
T
---
L
G
T
G
A
F
S
E
V
V
-
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P---------
K
-----
K
---
A
-----------------------
S
---
S
-----
I
E
---
N
---
E
I
A
V
L
R
K
I
---
K
-
H
-
E
-------
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
----
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
-
G
----
F
-
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
Q
-
D
-
E
E
---
S
K
-
I
M
I
S
------------------------------------
P
G
Y
V
A
P
E
V
L
------
A
------
Q
---
K
P
---
Y
-
S
-
K
-
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
---
E
----
N
D
S
-------
K
----------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
----
A
A
R
H
P
W
I
---
A
G
D
T
A
--
L
N
K
N
I
-
H
-
E
S
V
S
A
Q
-
I
R
K
N
F
-
A
K
S
K
W
R
Q
A
F
N
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.55
70%
-60
- C3 -
-
1A06
-
KCC1A_RAT
A:
[11-316]
---------------
K
--
Q
A
E
D
I
R
D
I
Y
-
D
F
R
D
V
---
L
G
T
G
A
F
S
E
V
I
-
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A---------
K
--------------------------------------------
E
---
N
---
E
I
A
V
L
H
K
I
---
K
-
H
-
P
-------
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
-
G
----
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
-
E
D
---
S
K
-
I
M
I
S
D
F
----------------------------------
P
G
Y
V
A
P
E
V
L
------
A
------
Q
---
K
P
---
Y
-
S
-
K
-
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
---
E
----
N
D
A
-------
K
----------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
----
A
L
Q
H
P
W
I
---
A
G
D
T
A
--
L
D
K
N
I
-
H
-
Q
S
V
S
E
Q
-
I
K
K
N
F
-
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
H
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
77.32
73%
-53
- C3 -
-
2JC6
1
KCC1D_HUMAN
C:
[12-314]
----------
S
W
K
--
K
--
Q
A
E
D
I
K
K
I
F
-
E
F
K
E
T
---
L
G
T
G
A
F
S
E
V
V
-
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P---------
K
-----
K
---
A
---------------------------
S
-----
I
E
---
N
---
E
I
A
V
L
R
K
I
---
K
-
H
-
E
-------
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
----
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
-
G
----
F
-
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
Q
-
D
-
E
E
---
S
K
-
I
M
I
S
------------------------------------
P
G
Y
V
A
P
E
V
L
------
A
------
Q
---
K
P
---
Y
-
S
-
K
-
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
---
E
----
N
D
S
-------
K
----------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
----
A
A
R
H
P
W
I
---
A
G
D
T
A
--
L
N
K
N
I
-
H
-
E
S
V
S
A
Q
-
I
R
K
N
F
-
A
K
S
K
W
R
Q
A
F
N
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.93
70%
-42
- C3 -
-
4FG9
1
KCC1A_HUMAN
A:
[11-314]
---------------
K
--
Q
A
E
D
I
R
D
I
Y
-
D
F
R
D
V
---
L
G
T
G
A
F
S
E
V
I
-
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A---------
K
-----
E
--------------------------------------
E
---
N
---
E
I
A
V
L
H
K
I
---
K
-
H
-
P
-------
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
-
G
----
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
-
E
D
---
S
K
-
I
M
I
S
D
F
----------------------------------
P
G
Y
V
A
P
E
V
L
------
A
------
Q
---
K
P
---
Y
-
S
-
K
-
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
---
E
----
N
D
A
-------
K
----------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
----
A
L
Q
H
P
W
I
---
A
G
D
T
A
--
L
D
K
N
I
-
H
-
Q
S
V
S
E
Q
-
I
K
K
N
F
-
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
73.70
71%
-49
- C3 -
-
4FG9
1
KCC1A_HUMAN
B:
[14-314]
--------------------
E
D
I
R
D
I
Y
-
D
F
R
D
V
---
L
G
T
G
A
F
S
E
V
I
-
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A---------
K
----------------------------------------------------
E
I
A
V
L
H
K
I
---
K
-
H
-
P
-------
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
-
G
----
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
-
E
D
---
S
K
-
I
M
I
S
D
F
----------------------
V
-
L
S
--
T
A
-
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
---
K
P
---
Y
-
S
-
K
-
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
---
E
----
N
D
A
-------
K
----------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
----
A
L
Q
H
P
W
I
---
A
G
D
T
A
--
L
D
K
N
I
-
H
-
Q
S
V
S
E
Q
-
I
K
K
N
F
-
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
72.81
70%
-57
- C3 -
-
4FG8
1
KCC1A_HUMAN
A:
[11-299]
---------------
K
--
Q
A
E
D
I
R
D
I
Y
-
D
F
R
D
V
---
L
G
T
G
A
F
S
E
V
I
-
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A---------
K
--------------------------------------------
E
---
N
---
E
I
A
V
L
H
K
I
---
K
-
H
-
P
-------
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
-
G
----
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
-
E
D
---
S
K
-
I
M
I
S
D
F
---------------------------------
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
---
K
P
---
Y
-
S
-
K
-
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
---
E
----
N
D
A
-------
K
----------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
----
A
L
Q
H
P
W
I
---
A
G
D
T
A
--
L
D
K
N
I
-
H
-
Q
S
V
S
E
Q
-
I
K
K
N
F
-
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
71.21
70%
-32
- C3 -
-
4FG8
1
KCC1A_HUMAN
B:
[14-299]
--------------------
E
D
I
R
D
I
Y
-
D
F
R
D
V
---
L
G
T
G
A
F
S
E
V
I
-
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A---------
K
------------------------------------------------
N
---
E
I
A
V
L
H
K
I
---
K
-
H
-
P
-------
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
-
G
----
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
-
E
D
---
S
K
-
I
M
I
S
D
F
G
-------------------
G
S
V
-
L
S
--
T
A
-
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
---
K
P
---
Y
-
S
-
K
-
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
---
E
----
N
D
A
-------
K
----------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
----
A
L
Q
H
P
W
I
---
A
G
D
T
A
--
L
D
K
N
I
-
H
-
Q
S
V
S
E
Q
-
I
K
K
N
F
-
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
70.46
69%
-56
- C3 -
-
4FG7
1
KCC1A_HUMAN
A:
[11-277]
---------------
K
--
Q
A
E
D
I
R
D
I
Y
-
D
F
R
D
V
---
L
G
T
G
A
F
S
E
V
I
-
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A-----------------------------------------------
S
-----
M
E
---
N
---
E
I
A
V
L
H
K
I
---
K
-
H
-
P
-------
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
----
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
-
G
----
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
-
D
-
E
D
---
S
K
-
I
M
I
S
D
F
G
L
S
---
K
-
M
--
E
--
D
----
P
------------
G
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
---
K
------
S
-
K
-
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
---
E
----
N
D
A
-------
K
----------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
-
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
----
A
L
Q
H
P
W
I
---
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
68.00
37%
-18
- C3 -
-
3MFS
1
CSKP_HUMAN
A:
[30-320]
-------------------------------
E
V
---
I
G
K
G
A
F
S
V
V
R
-
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
----------
D
VAKFT
S
---
S
P
------
G
L
--------
S
T
----
E
---
D
-----
L
K
---
R
---
E
A
S
I
C
H
M
L
---
K
-
H
-
P
-------
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
-
A
DAGF
V
-
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
-
E
-
N
S
---
A
P
-
V
K
L
G
D
F
G
V
A
I--
Q
-
L
--
G
--
E
----
S
G
-
L
-
V
A
--
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
------
K
------
R
---
E
P
---
Y
-
G
-
K
-
P
-
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
-------
G
----
T
K
E
-------
R
----------
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
----
A
L
N
H
P
W
L
---
K
E
R
D
R
--
Y
A
Y
K
I
-
H
L
P
E
T
V
E
Q
-
L
R
K
F
N
-
A
R
R
K
L
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
67.60
44%
-104
- C3 -
-
2YIT
1
CHK2_HUMAN
A:
[8-278]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
G
A
C
G
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
------------
L
------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
G
--
E
----
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
341
Blastp_CBE
67.54
36%
-18
- C3 -
-
3C0G
1
CSKP_HUMAN
B:
[30-335]
-------------------------------
E
V
---
I
G
K
G
P
F
S
V
V
R
-
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
----------
D
VAKFT
S
---
S
P
------
G
L
--------
S
T
----
E
---
D
-----
L
K
---
R
---
E
A
S
I
C
H
M
L
---
K
-
H
-
P
-------
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
-
A
DAGF
V
-
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
-
E
-
N
S
---
A
P
-
V
K
L
G
G
F
G
V
A
I--
Q
-
L
--
G
--
E
----
S
G
-
L
-
V
A
--
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
------
K
------
R
---
E
P
---
Y
-
G
-
K
-
P
-
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
---
G
--------
T
K
E
-------
R
----------
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
----
A
L
N
H
P
W
L
---
K
E
R
D
R
--
Y
A
Y
K
I
-
H
L
P
E
T
V
E
Q
-
L
R
K
F
N
-
A
R
R
K
L
K
G
A
V
L
A
A
V
S
S
H
K
F
N
S
F
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
67.31
44%
-102
- C3 -
-
2WTD
4
CHK2_HUMAN
A:
[14-284]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
----
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
----
P
------
A
L
------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
----------
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
342
Blastp_CBE
67.17
36%
-15
- C3 -
-
3C0G
1
CSKP_HUMAN
A:
[30-335]
-------------------------------
E
V
---
I
G
K
G
P
F
S
V
V
R
-
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
----------
D
VAKFT
S
---
S
P
------
G
L
--------
S
T
----
E
---
D
-----
L
K
---
R
---
E
A
S
I
C
H
M
L
---
K
-
H
-
P
-------
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
-
A
DAGF
V
-
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
-
E
-
N
S
---
A
P
-
V
K
L
G
G
F
G
V
A
I--
Q
-
L
--
G
--
E
----
S
G
-
L
-
V
A
--
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
------
K
------
R
---
E
P
---
Y
-
G
-
K
-
P
-
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
---
G
--------
T
K
E
-------
R
----------
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
----
A
L
N
H
P
W
L
---
K
E
R
D
R
--
Y
A
Y
K
I
-
H
L
P
E
T
V
E
Q
-
L
R
K
F
N
-
A
R
R
K
L
K
--
V
L
A
A
V
------
S
F
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
67.09
37%
-15
- C3 -
-
3MFU
1
CSKP_HUMAN
A:
[30-320]
-------------------------------
E
V
---
I
G
K
G
A
F
S
V
V
R
-
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
----------
D
VAKFT
S
---
S
P
------
G
L
--------
S
T
----
E
---
D
-----
L
K
---
R
---
E
A
S
I
C
H
M
L
---
K
-
H
-
P
-------
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
----
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
-
A
DAGF
V
-
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
-
E
-
N
S
---
A
P
-
V
K
L
G
D
F
G
V
A
I--
Q
-
L
--
G
--
E
----
S
G
-
L
-
V
A
--
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
------
K
------
R
---
E
P
---
Y
-
G
-
K
-
P
-
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
-------
G
----
T
K
E
-------
R
----------
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
-
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
----
A
L
N
H
P
W
L
---
K
E
R
D
R
--
Y
A
Y
K
I
-
H
L
P
E
T
V
E
Q
-
L
R
K
F
N
-
A
R
R
K
L
K
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
67.04
44%
-94
- C3 -
-
4A9T
4
CHK2_HUMAN
A:
[14-284]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
---
G
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
----
P
------
A
L
------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
G
--
E
----
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
67.00
44%
-100
- C3 -
-
2W7X
3
CHK2_HUMAN
A:
[8-278]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
G
A
-
G
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
-------------------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
G
--
E
----
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
66.82
41%
-103
- C3 -
-
4MVF
2
CDPK2_PLAFK
A:
[55-379]
----------------------
L
E
D
K
Y
-
I
I
D
E
K
---
L
G
Q
G
T
Y
G
C
V
Y
-
K
G
I
D
K
V
T
N
Q
L
Y
A
I
K
E
E
----------
K
-----
K
---
D
R
------
L
K
--------
N
I
----
N
---
R
-----
F
F
---
Q
---
E
I
E
I
M
K
K
L
---
D
-
H
-
P
-------
N
I
V
K
L
Y
E
T
Y
E
N
D
N
Y
----
I
Y
L
I
M
E
L
C
S
G
R
E
L
F
D
S
I
I
E
N
-
G
----
S
-
F
T
E
K
N
A
A
T
I
M
K
Q
I
F
S
A
I
F
Y
L
H
S
L
N
I
V
H
R
D
L
K
P
E
N
F
L
F
Q
S
E
-
N
-
K
D
---
S
L
-
L
K
I
I
D
F
G
L
S
---
K
-
N
--
L
------------------------------------------------
K
----
Y
-
D
-
K
-
K
-
C
D
I
W
S
S
G
V
I
M
Y
T
L
L
C
G
Y
P
P
F
Y
-------------------------------------------
C
F
Y
E
N
D
W
G
-
S
I
S
S
D
A
K
N
L
I
T
K
L
L
T
Y
N
P
N
E
R
C
T
I
E
E
----
A
L
N
H
P
W
I
---
T
Q
M
T
K
--
S
--
H
V
E
L
-
S
S
T
L
L
K
-
N
L
K
N
F
-
K
K
E
N
E
L
K
K
I
A
L
T
I
I
A
K
H
L
C
D
V
E
I
N
N
L
R
N
I
F
I
A
L
D
V
D
N
---------------------------------------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
66.78
44%
-98
- C3 -
-
4BDI
6
CHK2_HUMAN
A:
[14-284]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
----
G
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
-----------
A
L
------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
G
--
E
----
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
66.75
44%
-99
- C3 -
-
4BDF
3
CHK2_HUMAN
A:
[14-284]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
----
G
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
-------------------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
G
--
E
----
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Blastp_CBE
66.65
44%
-99
- C3 -
-
2XK9
1
CHK2_HUMAN
A:
[7-277]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
G
A
-
G
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
-------------------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
G
--
E
----
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
66.56
44%
-99
- C3 -
-
2YIR
1
CHK2_HUMAN
A:
[8-278]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
G
A
C
G
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
------------
L
------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
G
--
E
----
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
66.55
44%
-98
- C3 -
-
2XBJ
1
CHK2_HUMAN
A:
[14-284]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
G
A
-
G
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
-----------
A
L
------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
----------
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
66.50
44%
-101
- C3 -
-
2YCQ
1
CHK2_HUMAN
A:
[8-278]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
G
A
C
G
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
-------------------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
G
--
E
----
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
66.48
44%
-98
- C3 -
-
4BDK
4
CHK2_HUMAN
A:
[14-284]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
----
G
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
-----------
A
L
------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
G
--
E
----
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
66.47
44%
-97
- C3 -
-
2YCF
1
CHK2_HUMAN
A:
[8-278]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
G
A
C
G
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
-------------------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
G
--
E
----
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
66.30
44%
-102
- C3 -
-
2WTI
3
CHK2_HUMAN
A:
[14-284]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
----
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
----
P
------
A
L
------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
-----
E
----
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
66.28
44%
-103
- C3 -
-
2W0J
1
CHK2_HUMAN
A:
[8-279]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
---
G
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
-------------------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
----------
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Blastp_CBE
66.15
44%
-101
- C3 -
-
4BDG
2
CHK2_HUMAN
A:
[14-284]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
---
G
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
-------------------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
G
--
E
----
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
66.08
44%
-96
- C3 -
-
2XM9
1
CHK2_HUMAN
A:
[14-284]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
---
G
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
----
P
------
A
L
------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
G
--
E
----
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Blastp_CBE
66.05
44%
-100
- C3 -
-
2YCR
1
CHK2_HUMAN
A:
[8-278]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
---
G
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
-------------------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
G
--
E
----
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
65.93
44%
-97
- C3 -
-
4A9R
2
CHK2_HUMAN
A:
[14-284]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
------
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
----
P
------
A
L
------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
G
--
E
----
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
65.82
44%
-101
- C3 -
-
4A9S
1
CHK2_HUMAN
A:
[14-284]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
------
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
----
P
------
A
L
------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
----------
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
65.81
44%
-102
- C3 -
-
4A9U
10
CHK2_HUMAN
A:
[14-284]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
----
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
---
D
P
------
A
L
------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
----------
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
65.66
44%
-99
- C3 -
-
2YIQ
1
CHK2_HUMAN
A:
[8-278]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
----
G
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
-------------------------------------
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
G
--
E
----
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
65.60
44%
-103
- C3 -
-
2WTJ
5
CHK2_HUMAN
A:
[14-284]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
----
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
----
P
------
A
L
------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
-----
E
----
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
65.26
44%
-101
- C3 -
-
2WTC
1
CHK2_HUMAN
A:
[14-284]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
----
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
----
P
------
A
L
------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
----------
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
65.10
44%
-107
- C3 -
-
4BDH
4
CHK2_HUMAN
A:
[14-284]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
------
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
-------------------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
G
--
E
----
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Blastp_CBE
64.97
44%
-104
- C3 -
-
2YCS
1
CHK2_HUMAN
A:
[8-278]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
---
G
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
-------------------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
----------
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
64.28
44%
-110
- C3 -
-
4BDD
3
CHK2_HUMAN
A:
[14-284]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
------
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
-------------------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
----------
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
64.18
44%
-106
- C3 -
-
4BDA
8
CHK2_HUMAN
A:
[14-284]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
----
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
-------------------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
-----
E
----
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
64.13
44%
-106
- C3 -
-
4BDB
10
CHK2_HUMAN
A:
[14-284]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
------
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
------------
L
------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
-----
E
----
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
64.02
44%
-106
- C3 -
-
4BDE
5
CHK2_HUMAN
A:
[14-284]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
------
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
-----------
A
L
------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
----------
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
63.99
44%
-106
- C3 -
-
4BDJ
1
CHK2_HUMAN
A:
[14-284]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
-----
G
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
-------------------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
-----
E
----
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
63.25
38%
10
- C3 -
-
2CKE
1
DAPK2_HUMAN
A:
[18-302]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
K
-
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
----------
K
-----
K
RQ-
S
R
------
A
S
--------
R
R
GVSR
E
---
E
-----
I
E
---
R
---
E
V
S
I
L
R
Q
V
---
L
-
H
-
H
-------
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
-
E
----
S
-
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
-
K
N
IPI
P
H
-
I
K
L
I
D
F
G
L
A
---
H
-
E
--
I
--
E
----
D
G
-
V
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
-
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
----
A
L
R
H
P
W
I
TPV
D
N
Q
Q
A
--
M
V
R
R
--
E
-
S
V
V
N
L
E
N
F
R
K
Q
Y
-
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
63.18
44%
-102
- C3 -
-
2CN8
1
CHK2_HUMAN
A:
[14-284]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
----
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
-------------------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
----------
T
S
-
L
-
M
R
--
T
L
-
C
--
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H---------
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
63.03
45%
-61
- C3 -
-
5JZN
1
DCLK1_HUMAN
A:
[27-279]
------------------------------------
I
G
D
G
N
F
A
V
V
K
-
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
----------
K
-----
K
---
S
K
------
C
R
G-------
K
E
----
H
---
M
-----
I
Q
---
N
---
E
V
S
I
L
R
R
V
---
K
-
H
-
P
-------
N
I
V
L
L
I
E
E
M
D
V
P
T
E
----
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
S
T
-
N
----
K
-
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
-
Q
-
D
G
---
S
K
S
L
K
L
G
D
F
G
L
A
---
T
-
I
-----
V
----
D
G
-
P
-
L
Y
--
T
V
-
C
G
T
P
T
Y
V
A
P
E
I
I
------
A
------
E
---
T
G
---
Y
-
G
-
L
-
K
-
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
---
G
---
S
------
D
-------
Q
EV--------
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
-
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
V
Q
----
V
L
E
H
P
W
V
---
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
62.92
40%
-22
- C3 -
-
4YZB
1
?
B:
[37-335]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
----------
S
-----
K
---
R
-----------------
Q
K
----
T
---
D
-----
K
E
---
L
---
L
L
K
E
V
E
L
L
KKL
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
N
K
-
R
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
S
----
T
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
F
-------
D
----------
I
L
K
K
V
E
K
G
K
F
T
F
D
L
P
Q
W
K
-
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
S
A
R
D
----
A
L
E
H
E
W
L
---
K
T
--------
S
I
D
V
-
P
S
L
E
S
T
-
I
L
-
N
I
-
R
Q
F
Q
G
T
Q
K
L
A
A
A
A
L
L
Y
M
G
S
K
L
T
T
-
N
---------------------------------------------------------------------------------------------------------------------------------------------------------
47
Blastp_CBE
62.73
42%
4
- C3 -
-
3SOA
1
KCC2A_HUMAN
A:
[7-303]
--------------------
T
R
F
T
E
E
Y
-
Q
L
F
E
E
---
L
G
K
G
--
S
V
V
R
-
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
NT--------
K
-----
K
---
L
S
------
A
R
--------
D
H
----
Q
---
K
-----
L
E
---
R
---
E
A
R
I
C
R
L
L
---
K
-
H
-
P
-------
N
I
V
R
L
H
D
S
I
S
E
E
G
H
----
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
-
L
-
K
G
---
A
A
-
V
K
L
A
D
F
G
L
A
IEV
E
-
G
--
E
--
Q
----
Q
A
-
W
-
F
G
--
F
A
--
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
---
D
P
---
Y
-
G
-
K
-
P
-
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
----
D
Q
H
-------
R
----------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
----
A
L
K
H
P
W
I
---
S
H
R
S
T
--
V
A
S
C
M
-
H
-
R
Q
E
T
V
D
-
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
376
Blastp_CBE
62.70
35%
-130
- C3 -
-
5TX3
2
MELK_HUMAN
B:
[6-267]
---------------
K
--
D
Y
D
E
L
L
K
Y
Y
-
E
L
H
E
T
---
I
G
-----
K
V
K
-
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
----------
D
-----
K
--------------------------------------
K
---
T
---
E
I
E
A
L
K
N
L
---
R
-
H
-
Q
-------
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
-
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
----
D
-
E
Y
---
H
K
-
L
K
L
I
D
---------------------------------
G
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
---------L
G
-
S
-
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
----
N
V
M
-------
A
----------
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
----
L
L
N
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
62.61
41%
-94
- C3 -
-
3ZXT
1
DAPK1_HUMAN
D:
[17-275]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
-----------------------------
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
---------------------
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
62.60
44%
-4
- C3 -
-
2V7O
3
KCC2G_HUMAN
A:
[27-291]
--------------------
T
R
F
T
D
D
Y
-
Q
L
F
E
E
---
L
G
K
G
-
F
S
V
V
R
-
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
NT--------
K
-----
K
---
L
S
------
A
R
--------
D
H
----
Q
---
K
-----
L
E
---
R
---
E
A
R
I
C
R
L
L
---
K
-
H
-
P
-------
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
C
-
K
G
---
A
A
-
V
K
L
A
D
F
G
L
A
IEV
Q
-
G
--
E
--
Q
----
Q
A
-
W
-
F
G
--
F
A
--
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
---
D
P
---
Y
-
G
-
K
-
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
----
D
Q
H
-------
K
----------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
----
A
L
K
H
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
164
Blastp_CBE
62.56
38%
11
- C3 -
-
2CKE
1
DAPK2_HUMAN
B:
[18-302]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
K
-
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
----------
K
-----
K
RQ-
S
R
------
A
S
--------
R
R
GVSR
E
---
E
-----
I
E
---
R
---
E
V
S
I
L
R
Q
V
---
L
-
H
-
H
-------
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
-
E
----
S
-
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
-
K
N
IPI
P
H
-
I
K
L
I
D
F
G
L
A
---
H
-
E
--
I
--
E
----
D
G
-
V
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
-
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
----
A
L
R
H
P
W
I
TPV
D
N
Q
Q
A
--
M
V
R
R
--
E
-
S
V
V
N
L
E
N
F
R
K
Q
Y
-
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
62.37
42%
2
- C3 -
-
3BHH
1
KCC2B_HUMAN
B:
[6-293]
--------------------------
Y
-
Q
L
Y
E
D
---
I
G
K
---
S
V
V
R
-
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
NT--------
K
-----
K
---
L
S
------
A
R
--------
D
H
----
Q
---
K
-----
L
E
---
R
---
E
A
R
I
C
R
L
L
---
K
-
H
-
S
-------
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
C
-
K
G
---
A
A
-
V
K
L
A
D
F
G
L
A
IEV
Q
-
G
--
D
--
Q
----
Q
A
-
W
-
F
G
--
F
A
--
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
---
E
A
---
Y
-
G
-
K
-
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
----
D
Q
H
-------
K
----------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
----
A
L
K
H
P
W
V
---
C
Q
R
S
T
--
V
A
S
M
M
-
H
-
R
Q
E
T
V
E
-
C
L
K
K
F
N
A
R
R
K
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
175
Blastp_CBE
62.22
39%
-69
- C3 -
-
4JG8
1
A:
[41-308]
-------------------------------
E
D
---
I
G
V
G
S
Y
S
V
C
K
-
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
----------
D
-----
K
---
S
K
----------------
R
D
----
P
---
T
-----
E
E
---
I
---
E
I
-
L
L
R
Y
G
---
Q
-
H
-
P
-------
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
----
V
Y
V
V
M
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
-
K
----
F
-
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
-
S
-
G
N
P--
E
S
-
I
R
I
C
D
F
G
F
A
---
K
-
Q
LR
A
--
E
----
N
G
-
L
-
L
M
--
T
P
-
C
Y
T
A
N
F
V
A
P
E
V
L
------
E
------
R
---
Q
G
---
Y
-
D
-
A
-
A
-
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
NGP
D
---
D
----
T
P
E
-------
E
----------
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
-
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
----
V
L
R
H
P
W
I
----------
V
H
W
D
Q
-
L
-
P
Q
Y
Q
L
N
-
R
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
62.20
39%
-68
- C3 -
-
4D9U
1
A:
[28-295]
-------------------------------
E
D
---
I
G
V
G
S
Y
S
V
C
K
-
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
----------
D
-----
K
---
S
K
----------------
R
D
----
P
---
T
-----
E
E
---
I
---
E
I
-
L
L
R
Y
G
---
Q
-
H
-
P
-------
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
----
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
-
K
----
F
-
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
-
S
-
G
N
P--
E
S
-
I
R
I
C
D
F
G
F
A
---
K
-
Q
LR
A
--
E
----
N
G
-
L
-
L
M
--
T
P
-
C
Y
T
A
N
F
V
A
P
E
V
L
------
E
------
R
---
Q
G
---
Y
-
D
-
A
-
A
-
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
NGP
D
---
D
----
T
P
E
-------
E
----------
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
-
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
----
V
L
R
H
P
W
I
----------
V
H
W
D
Q
-
L
-
P
Q
Y
Q
L
N
-
R
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
62.18
40%
-71
- C3 -
-
3F3Z
5
?
A:
[6-266]
---------------------
D
I
N
Q
Y
Y
-
T
L
E
N
T
---
I
G
R
G
S
W
G
E
V
K
-
I
A
V
Q
K
G
T
R
I
R
R
A
A
K
K
I
----------
P
-----
K
---
Y
F
------
V
E
--------
D
V
----
D
---
R
-----
F
K
---
Q
---
E
I
E
I
M
K
S
L
---
D
-
H
-
P
-------
N
I
I
R
L
Y
E
T
F
E
D
N
T
D
----
I
Y
L
V
M
E
L
C
T
G
G
E
L
F
E
R
V
V
H
K
-
R
----
V
-
F
R
E
S
D
A
A
R
I
M
K
D
V
L
S
A
V
A
Y
C
H
K
L
N
V
A
H
R
D
L
K
P
E
N
F
L
F
L
T
D
-
S
-
P
D
---
S
P
-
L
K
L
I
D
F
G
L
A
---
A
-
R
--
F
--
K
----
P
G
K
M
-
M
R
--
T
K
-
V
G
T
P
Y
Y
V
S
P
Q
V
L
-------------
E
---
G
L
---
Y
-
G
-
P
-
E
-
C
D
E
W
S
A
G
V
M
M
Y
V
L
L
C
G
Y
P
P
F
S
---
A
---
P
----
T
D
E
-------
V
----------
M
L
-
K
I
R
E
G
T
F
T
F
P
E
K
D
W
L
-
N
V
S
P
Q
A
E
S
L
I
R
R
L
L
T
K
S
P
K
Q
R
I
T
S
L
Q
----
A
L
E
H
E
W
F
---
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
62.16
40%
-20
- C3 -
-
4YZB
1
?
A:
[37-335]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
----------
S
-----
K
---
R
-----------------
Q
K
----
T
---
D
-----
K
E
---
L
---
L
L
K
E
V
E
L
L
KKL
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
N
K
-
R
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
S
----
T
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
F
-------
D
----------
I
L
K
K
V
E
K
G
K
F
T
F
D
L
P
Q
W
K
-
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
S
A
R
D
----
A
L
E
H
E
W
L
---
K
T
------
T
D
S
I
D
V
-
P
S
L
E
S
T
-
I
L
-
N
I
-
R
Q
F
Q
G
T
Q
K
L
A
A
A
A
L
L
Y
M
G
S
K
L
T
T
-
N
---------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
61.96
35%
-58
- C3 -
-
5TWL
1
MELK_HUMAN
A:
[3-264]
---------------
K
--
D
Y
D
E
L
L
K
Y
Y
-
E
L
H
E
T
---
I
G
T
G
G
F
A
K
V
K
-
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
----------
D
-----
K
---
N
T
------
L
G
--------
S
D
L---
P
---
R
-----
I
K
---
T
---
E
I
E
A
L
K
N
L
---
R
-
H
-
Q
-------
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
-
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
----
D
-
E
Y
---
H
K
-
L
K
L
I
D
F
G
L
-----------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
---
K
S
---
Y
L
G
-
S
-
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
----
N
V
M
-------
A
----------
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
----
L
L
N
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
61.86
42%
1
- C3 -
-
3BHH
1
KCC2B_HUMAN
A:
[6-293]
--------------------------
Y
-
Q
L
Y
E
D
---
I
G
----
S
V
V
R
-
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
NT--------
K
-----
K
---
L
S
------
A
R
--------
D
H
----
Q
---
K
-----
L
E
---
R
---
E
A
R
I
C
R
L
L
---
K
-
H
-
S
-------
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
C
-
K
G
---
A
A
-
V
K
L
A
D
F
G
L
A
IEV
Q
-
G
--
D
--
Q
----
Q
A
-
W
-
F
G
--
F
A
--
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
---
E
A
---
Y
-
G
-
K
-
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
----
D
Q
H
-------
K
----------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
----
A
L
K
H
P
W
V
---
C
Q
R
S
T
--
V
A
S
M
M
-
H
-
R
Q
E
T
V
E
-
C
L
K
K
F
N
A
R
R
K
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
372
Blastp_CBE
61.85
35%
-67
- C3 -
-
4BFM
1
MELK_MOUSE
A:
[2-263]
---------------
K
--
D
Y
D
E
L
L
K
Y
Y
-
E
L
Y
E
T
---
I
G
T
G
G
F
A
K
V
K
-
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
----------
D
-----
K
---
N
A
------
L
G
--------
S
D
L---
P
---
R
-----
V
K
---
T
---
E
I
D
A
L
K
S
L
---
R
-
H
-
Q
-------
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
-
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
----
D
-
E
N
---
H
K
-
L
K
L
I
D
F
G
L
C
AK--------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
------
Q
-----------------
G
-
S
-
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
----
N
V
M
-------
A
----------
L
Y
K
K
I
M
R
G
K
Y
E
V
--
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
R
N
----
L
L
N
H
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
61.84
44%
-109
- C3 -
-
2XM8
1
CHK2_HUMAN
A:
[14-284]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
-----
G
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------------------------------------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
----------
T
S
-
L
-
M
R
--
T
L
-
C
G
---
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
208
Blastp_CBE
61.80
39%
-64
- C3 -
-
4JG7
1
A:
[41-308]
-------------------------------
E
D
---
I
G
V
--
Y
S
V
C
K
-
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
----------
D
-----
K
---
S
K
----------------
R
D
----
P
---
T
-----
E
E
---
I
---
E
I
-
L
L
R
Y
G
---
Q
-
H
-
P
-------
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
----
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
-
K
----
F
-
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
-
S
-
G
N
P--
E
S
-
I
R
I
C
D
F
G
F
A
---
K
-
Q
LR
A
--
E
----
N
G
-
L
-
L
M
--
T
P
-
C
Y
T
A
N
F
V
A
P
E
V
L
------
E
------
R
---
Q
G
---
Y
-
D
-
A
-
A
-
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
NGP
D
---
D
----
T
P
E
-------
E
----------
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
-
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
----
V
L
R
H
P
W
I
----------
V
H
W
D
Q
-
L
-
P
Q
Y
Q
L
N
-
R
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
61.79
39%
13
- C3 -
-
2YAA
1
DAPK2_MOUSE
A:
[18-302]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
K
-
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
----------
K
-----
K
RQ-
S
R
------
A
S
--------
R
R
GVCR
E
---
E
-----
I
E
---
R
---
E
V
S
I
L
R
Q
V
---
L
-
H
-
P
-------
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
-
E
----
S
-
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
-
K
N
IPI
P
H
-
I
K
L
I
D
F
G
L
A
---
H
-
E
--
I
--
E
----
D
G
-
V
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
-
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
----
A
L
R
H
P
W
I
TPV
D
T
Q
Q
A
--
M
V
R
R
--
E
-
S
V
V
N
L
E
N
F
K
K
Q
Y
-
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
219
Blastp_CBE
61.68
40%
-11
- C3 -
-
4YUQ
1
?
A:
[37-335]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
----------
S
-----
K
---
R
Q
-------------------------------------
L
---
L
L
K
E
V
E
L
L
KKL
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
N
K
-
R
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
S
----
T
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
F
-------
D
----------
I
L
K
K
V
E
K
G
K
F
T
F
D
L
P
Q
W
K
-
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
S
A
R
D
----
A
L
E
H
E
W
L
---
K
T
T
D
-----
D
S
I
D
V
-
P
S
L
E
S
T
-
I
L
-
N
I
-
R
Q
F
Q
G
T
Q
K
L
A
A
A
A
L
L
Y
M
G
S
K
L
T
T
-
N
---------------------------------------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
61.68
38%
13
- C3 -
-
2CKE
1
DAPK2_HUMAN
D:
[18-302]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
K
-
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
----------
K
-----
K
RQ-
S
R
------
A
S
--------
R
R
GVSR
E
---
E
-----
I
E
---
R
---
E
V
S
I
L
R
Q
V
---
L
-
H
-
H
-------
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
-
E
----
S
-
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
-
K
N
IPI
P
H
-
I
K
L
I
D
F
G
L
A
---
H
-
E
--
I
--
E
----
D
G
-
V
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
-
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
----
A
L
R
H
P
W
I
TPV
D
N
Q
Q
A
--
M
V
R
R
--
E
-
S
V
V
N
L
E
N
F
R
K
Q
Y
-
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
61.63
44%
-43
- C3 -
-
2CN5
1
CHK2_HUMAN
A:
[14-284]
----------------------
L
R
D
E
Y
-
I
M
S
K
T
---
L
G
S
G
A
C
G
E
V
K
-
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
----------
S
-----
K
R------------------------------
N
-----
V
E
---
T
---
E
I
E
I
L
K
K
L
---
N
-
H
-
P
-------
C
I
I
K
I
K
N
F
F
D
A
E
-
D
----
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
-
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
-
E
-
E
D
---
C
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
G
--
E
----
T
S
-
L
-
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
------
V
------
S
VGT
A
G
---
Y
-
N
-
R
-
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
---
E
H--
R
----
T
Q
V
-------
S
----------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
-
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
----
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
374
Blastp_CBE
61.58
35%
-68
- C3 -
-
4UMT
2
MELK_HUMAN
A:
[23-283]
------------------
D
Y
D
E
L
L
K
Y
Y
-
E
L
H
E
T
---
I
G
T
G
G
F
A
K
V
K
-
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
----------
D
-----
K
---
N
T
------
L
G
--------
S
D
L---
P
---
R
-----
I
K
---
T
---
E
I
E
A
L
K
N
L
---
R
-
H
-
Q
-------
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
-
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
----
D
-
E
Y
---
H
K
-
L
K
L
I
D
F
G
L
-----------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
---
K
S
---
Y
L
G
-
S
-
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
----
T
A
A
-------
A
----------
L
V
A
K
I
M
R
G
K
Y
D
V
--
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
----
L
L
N
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
152
Blastp_CBE
61.53
39%
8
- C3 -
-
2YAA
1
DAPK2_MOUSE
B:
[18-302]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
K
-
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
----------
K
-----
K
RQ-
S
R
------
A
S
--------
R
R
GVCR
E
---
E
-----
I
E
---
R
---
E
V
S
I
L
R
Q
V
---
L
-
H
-
P
-------
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
-
E
----
S
-
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
-
K
N
IPI
P
H
-
I
K
L
I
D
F
G
L
A
---
H
-
E
--
I
--
E
----
D
G
-
V
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
-
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
----
A
L
R
H
P
W
I
TPV
D
T
Q
Q
A
--
M
V
R
R
--
E
-
S
V
V
N
L
E
N
F
K
K
Q
Y
-
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
61.41
45%
-65
- C3 -
-
5JZJ
1
B:
[44-296]
------------------------------------
I
G
D
G
N
F
A
V
V
K
-
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
----------
K
-----
K
---
S
K
------
C
R
G-------
K
E
----
H
---
M
-----
I
Q
---
N
---
E
V
S
I
L
R
R
V
---
K
-
H
-
P
-------
N
I
V
L
L
I
E
E
M
D
V
P
T
E
----
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
S
T
-
N
----
K
-
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
-
Q
-
D
G
---
S
K
S
L
K
L
G
D
F
G
L
A
---
T
-
I
-----
V
----
D
G
-
P
-
L
Y
--
T
V
-
C
G
T
P
T
Y
V
A
P
E
I
I
------
A
------
E
---
T
G
---
Y
-
G
-
L
-
K
-
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
-----------------------EV--------
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
-
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
V
Q
----
V
L
E
H
P
W
V
---
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
61.33
45%
-61
- C3 -
-
5JZJ
2
DCLK1_HUMAN
A:
[44-296]
------------------------------------
I
G
D
G
N
F
A
V
V
K
-
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
----------
K
-----
K
---
S
K
------
C
R
G-------
K
E
----
H
---
M
-----
I
Q
---
N
---
E
V
S
I
L
R
R
V
---
K
-
H
-
P
-------
N
I
V
L
L
I
E
E
M
D
V
P
T
E
----
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
S
T
-
N
----
K
-
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
-
Q
-
D
G
---
S
K
S
L
K
L
G
D
F
G
L
A
---
T
-
I
-----
V
----
D
G
-
P
-
L
Y
--
T
V
-
C
G
T
P
T
Y
V
A
P
E
I
I
------
A
------
E
---
T
G
---
Y
-
G
-
L
-
K
-
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
---
G
---
S
---------------EV--------
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
-
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
V
Q
----
V
L
E
H
P
W
V
---
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
218
Blastp_CBE
61.24
40%
-12
- C3 -
-
4YUQ
1
?
B:
[37-335]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
----------
S
-----
K
---
R
Q
-----------------------------------------
L
L
K
E
V
E
L
L
KKL
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
N
K
-
R
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
S
----
T
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
F
-------
D
----------
I
L
K
K
V
E
K
G
K
F
T
F
D
L
P
Q
W
K
-
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
S
A
R
D
----
A
L
E
H
E
W
L
---
K
T
T
D
-----
D
S
I
D
V
-
P
S
L
E
S
T
-
I
L
-
N
I
-
R
Q
F
Q
G
T
Q
K
L
A
A
A
A
L
L
Y
M
G
S
K
L
T
T
-
N
---------------------------------------------------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
61.20
40%
-11
- C3 -
-
4YSJ
1
?
A:
[37-335]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
----------
S
-----
K
---
R
------------------------------------------
L
L
K
E
V
E
L
L
KKL
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
N
K
-
R
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
S
----
T
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
F
-------
D
----------
I
L
K
K
V
E
K
G
K
F
T
F
D
L
P
Q
W
K
-
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
S
A
R
D
----
A
L
E
H
E
W
L
---
K
T
T
-------
S
I
D
V
-
P
S
L
E
S
T
-
I
L
-
N
I
-
R
Q
F
Q
G
T
Q
K
L
A
A
A
A
L
L
Y
M
G
S
K
L
T
T
-
N
---------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
61.20
45%
-61
- C3 -
-
5JZN
1
B:
[27-279]
------------------------------------
I
G
D
G
N
F
A
V
V
K
-
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
----------
K
-----
K
---
S
K
------
C
R
G-------
K
E
----
H
---
M
-----
I
Q
---
N
---
E
V
S
I
L
R
R
V
---
K
-
H
-
P
-------
N
I
V
L
L
I
E
E
M
D
V
P
T
E
----
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
S
T
-
N
----
K
-
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
-
Q
-
D
G
---
S
K
S
L
K
L
G
D
F
G
L
A
---
T
-
I
-----
V
----
D
G
-
P
-
L
Y
--
T
V
-
C
G
T
P
T
Y
V
A
P
E
I
I
------
A
------
E
---
T
G
---
Y
-
G
-
L
-
K
-
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
---
G
---
S
--------------
Q
EV--------
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
-
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
V
Q
----
V
L
E
H
P
W
V
---
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
369
Blastp_CBE
61.15
39%
-52
- C3 -
-
2HW7
1
MKNK2_HUMAN
A:
[19-301]
-------------------------------
D
V
---
L
G
E
G
A
H
A
R
V
Q
-
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
----------
E
-----
K
---
Q
P
------
G
H
--------
I
R
----
S
---
R
-----
V
F
---
R
---
E
V
E
M
L
Y
Q
C
---
Q
G
H
-
R
-------
N
V
L
E
L
I
E
F
F
E
E
E
D
R
----
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
-
R
----
H
-
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
-
N
-
Q
V
---
S
P
-
V
K
I
C
D
F
G
-------------------------------
G
S
A
E
Y
M
A
P
E
V
V
EAFSE-
E
------
A
---
S
I
---
Y
-
D
-
K
-
R
-
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
V
---
G
---
R
----
C
----------CGACPACQNM
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
-
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
----
V
L
Q
H
P
W
V
---
Q
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
61.06
40%
-8
- C3 -
-
4YSJ
1
?
B:
[37-335]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
----------
S
-----
K
---
R
------------------------------------------
L
L
K
E
V
E
L
L
KKL
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
N
K
-
R
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
S
----
T
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
F
-------
D
----------
I
L
K
K
V
E
K
G
K
F
T
F
D
L
P
Q
W
K
-
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
S
A
R
D
----
A
L
E
H
E
W
L
---
K
T
T
D
A
----
D
S
I
D
V
-
P
S
L
E
S
T
-
I
L
-
N
I
-
R
Q
F
Q
G
T
Q
K
L
A
A
A
A
L
L
Y
M
G
S
K
L
T
T
-
N
---------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
61.01
48%
-12
- C3 -
-
3LIJ
1
?
A:
[45-301]
------------------------------------
L
G
S
---
G
E
V
L
-
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
----------
R
-----
K
-------------S-------
S
N
----
S
---
K
-----
L
L
---
E
---
E
V
A
V
L
K
L
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
----
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
-
M
----
K
-
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
E
-
K
D
---
A
L
-
I
K
I
V
D
F
G
L
S
---
A
-
V
F-
E
--
N
----
Q
K
-
K
-
M
K
--
E
R
-
L
G
T
A
Y
Y
I
A
P
E
V
L
-------------
R
---
K
K
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
---
G
---
Q
----
T
D
Q
-------
E
----------
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
-
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
----
A
L
E
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
60.98
39%
-59
- C3 -
-
6CK6
1
MKNK2_HUMAN
A:
[19-301]
-------------------------------
D
V
---
L
G
E
G
A
H
A
R
V
Q
-
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
----------
E
-----
K
---
Q
P
------
G
H
--------
I
R
----
S
---
R
-----
V
F
---
R
---
E
V
E
M
L
Y
Q
C
---
Q
G
H
-
R
-------
N
V
L
E
L
I
E
F
F
E
E
E
D
R
----
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
-
R
----
H
-
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
-
N
-
Q
V
---
S
P
-
V
K
I
C
D
F
G
-------------------------------
G
S
A
E
Y
M
A
P
E
V
V
EAFSE-
E
------
A
---
S
I
---
Y
-
D
-
K
-
R
-
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
V
---
G
---
R
----
C
----------CGACPACQNM
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
-
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
----
V
L
Q
H
P
W
V
---
Q
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
60.92
35%
-70
- C3 -
-
4CQG
1
MELK_MOUSE
A:
[2-263]
---------------
K
--
D
Y
D
E
L
L
K
Y
Y
-
E
L
Y
E
T
---
I
G
T
G
G
F
A
K
V
K
-
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
----------
D
-----
K
---
N
A
------
L
G
--------
S
D
L---
P
---
R
-----
V
K
---
T
---
E
I
D
A
L
K
S
L
---
R
-
H
-
Q
-------
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
-
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
----
D
-
E
N
---
H
K
-
L
K
L
I
D
F
G
L
C
AK--------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
------
Q
-----------------
G
-
S
-
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
----
N
V
M
-------
A
----------
L
Y
K
K
I
M
R
G
K
Y
E
V
--
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
R
N
----
L
L
N
H
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
60.90
44%
-29
- C3 -
-
3IGO
8
?
A:
[29-295]
--------------------------------
M
---
L
G
K
G
S
F
G
E
V
L
-
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
----------
N
-----
K
---
A
S
------
A
K
--------
N
K
T---
S
---
T
-----
I
L
---
R
---
E
V
E
L
L
K
K
L
---
D
-
H
-
P
-------
N
I
M
K
L
F
E
I
L
E
D
S
S
S
----
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
-
K
----
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
-
E
-
K
D
---
C
D
-
I
K
I
I
D
F
G
L
S
---
T
C
F
--
Q
--
Q
----
N
T
------------
T
A
Y
Y
I
A
P
E
V
L
-------------
R
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
---
G
---
K
----
N
E
Y
-------
D
----------
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
-
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
----
C
L
E
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
60.88
38%
15
- C3 -
-
2CKE
1
DAPK2_HUMAN
C:
[18-302]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
K
-
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
----------
K
-----
K
RQ-
S
R
------
A
S
--------
R
R
GVSR
E
---
E
-----
I
E
---
R
---
E
V
S
I
L
R
Q
V
---
L
-
H
-
H
-------
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
-
E
----
S
-
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
---
D
-
K
N
IPI
P
H
-
I
K
L
I
D
F
G
L
A
---
H
-
E
--
I
--
E
----
D
G
-
V
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
-
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
----
A
L
R
H
P
W
I
TPV
D
N
Q
Q
A
--
M
V
R
R
--
E
-
S
V
V
N
L
E
N
F
R
K
Q
Y
-
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
60.83
35%
-53
* C3 *
-
5TVT
1
MELK_HUMAN
A:
[3-264]
---------------
K
--
D
Y
D
E
L
L
K
Y
Y
-
E
L
H
E
T
---
I
G
T
G
G
F
A
K
V
K
-
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
----------
D
-----
K
---
N
T
------
L
G
--------
S
D
L---
P
---
R
-----
I
K
---
T
---
E
I
E
A
L
K
N
L
---
R
-
H
-
Q
-------
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
-
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
----
D
-
E
Y
---
H
K
-
L
K
L
I
D
F
G
L
C
AK---------------------------
G
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
---
K
S
---
Y
L
G
-
S
-
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
----
N
V
M
-------
A
----------
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
----
L
L
N
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
60.76
39%
-68
- C3 -
-
5O1S
2
A:
[50-317]
-------------------------------
E
D
---
I
-----
S
V
C
K
-
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
----------
D
-----
K
---
S
K
----------------
R
D
----
P
---
T
-----
E
E
---
I
---
E
I
-
L
L
R
Y
G
---
Q
-
H
-
P
-------
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
----
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
-
K
----
F
-
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
-
S
-
G
N
---
P
E
S
I
R
I
C
D
F
G
F
A
---
K
-
Q
LR
A
--
E
----
N
G
-
L
-
L
M
--
T
P
-
C
---
N
F
V
A
P
E
V
L
------
E
------
R
---
Q
G
---
Y
-
D
-
A
-
A
-
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
NGP
D
---
D
----
T
P
E
-------
E
----------
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
-
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
----
V
L
R
H
P
W
I
----------
V
H
W
D
Q
-
L
-
P
Q
Y
Q
L
N
-
R
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
60.76
45%
-19
- C3 -
-
5T6A
1
?
A:
[74-357]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
-----
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
60.71
39%
-65
- C3 -
-
4M8T
1
A:
[41-308]
-------------------------------
E
D
---
I
G
V
G
S
Y
S
V
C
K
-
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
----------
D
-----
K
---
S
K
----------------
R
D
----
P
---
T
-----
E
E
---
I
---
E
I
-
L
L
R
Y
G
---
Q
-
H
-
P
-------
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
----
V
Y
V
V
M
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
-
K
----
F
-
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
-
S
-
G
N
P--
E
S
-
I
R
I
C
D
F
G
F
A
---
K
-
Q
LR
A
--
E
----
N
G
-
L
-
L
M
--
T
P
-
C
Y
T
A
N
F
V
A
P
E
V
L
------
E
------
R
---
Q
G
---
Y
-
D
-
A
-
A
-
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
NGP
D
---
D
----
T
P
E
-------
E
----------
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
-
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
----
V
L
R
H
P
W
I
----------
V
H
W
D
Q
-
L
-
P
Q
Y
Q
L
N
-
R
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
60.71
45%
-27
- C3 -
-
4IEB
1
?
A:
[56-309]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
---------------
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
M
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
-
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
60.64
45%
-18
- C3 -
-
5T6K
1
?
A:
[74-357]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
-----
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
60.55
47%
-5
- C3 -
-
2VN9
2
KCC2D_HUMAN
A:
[6-264]
--------------------------
Y
-
Q
L
F
E
E
---
L
G
K
G
A
F
S
V
V
R
-
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
NT--------
K
-----
K
---
L
S
------
A
R
--------
D
H
----
Q
---
K
-----
L
E
---
R
---
E
A
R
I
C
R
L
L
---
K
-
H
-
P
-------
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
S
-
K
G
---
A
A
-
V
K
L
A
D
F
G
L
A
IEV
Q
-
G
--
D
--
Q
----
Q
A
-
W
-
F
G
--
F
A
--
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
---
D
P
---
Y
-
G
-
K
-
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
----
D
Q
H
-------
R
----------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
----
A
L
K
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
60.49
46%
-7
- C3 -
-
6AYW
2
KCC2D_HUMAN
A:
[9-273]
--------------------
T
R
F
T
D
E
Y
-
Q
L
F
E
E
---
L
G
K
G
A
F
S
V
V
R
-
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
NT--------
K
-----
K
---
L
S
------
A
R
--------
D
H
----
Q
---
K
-----
L
E
---
R
---
E
A
R
I
C
R
L
L
---
K
-
H
-
P
-------
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
S
-
K
G
---
A
A
-
V
K
L
A
D
F
G
L
A
IEV
Q
-
G
--
D
--
Q
----
Q
A
-
W
-
F
G
--
F
A
--
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
---
D
P
---
Y
-
G
-
K
-
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
----
D
Q
H
-------
R
----------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
----
A
L
K
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
418
Blastp_CBE
60.44
35%
-60
- C3 -
-
5K00
1
MELK_HUMAN
A:
[6-262]
----------------------
L
L
K
Y
Y
-
E
L
H
E
T
---
I
G
T
G
--
A
K
V
K
-
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
----------
D
-----
K
---
N
T
------
L
G
--------
S
D
L---
P
---
R
-----
I
K
---
T
---
E
I
E
A
L
K
N
L
---
R
-
H
-
Q
-------
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
-
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
----
D
-
E
Y
---
H
K
-
L
K
L
I
D
F
G
L
C
AKP---------------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
---
K
S
---
Y
L
G
-
S
-
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
----
N
V
M
-------
A
----------
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
----
L
L
N
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
60.43
46%
-2
- C3 -
-
6AYW
2
KCC2D_HUMAN
B:
[9-273]
--------------------
T
R
F
T
D
E
Y
-
Q
L
F
E
E
---
L
G
K
G
A
F
S
V
V
R
-
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
NT--------
K
-----
K
---
L
S
------
A
R
--------
D
H
----
Q
---
K
-----
L
E
---
R
---
E
A
R
I
C
R
L
L
---
K
-
H
-
P
-------
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
S
-
K
G
---
A
A
-
V
K
L
A
D
F
G
L
A
IEV
Q
-
G
--
D
--
Q
----
Q
A
-
W
-
F
G
--
F
A
--
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
---
D
P
---
Y
-
G
-
K
-
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
----
D
Q
H
-------
R
----------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
----
A
L
K
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
209
Blastp_CBE
60.38
39%
-65
- C3 -
-
4JG6
1
A:
[41-308]
-------------------------------
E
D
---
I
-----
S
V
C
K
-
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
----------
D
-----
K
---
S
K
----------------
R
D
----
P
---
T
-----
E
E
---
I
---
E
I
-
L
L
R
Y
G
---
Q
-
H
-
P
-------
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
----
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
-
K
----
F
-
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
-
S
-
G
N
P--
E
S
-
I
R
I
C
D
F
G
F
A
---
K
-
Q
LR
A
--
E
----
N
G
-
L
-
L
M
--
T
P
-
C
Y
T
A
N
F
V
A
P
E
V
L
------
E
------
R
---
Q
G
---
Y
-
D
-
A
-
A
-
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
NGP
D
---
D
----
T
P
E
-------
E
----------
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
-
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
----
V
L
R
H
P
W
I
----------
V
H
W
D
Q
-
L
-
P
Q
Y
Q
L
N
-
R
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
60.33
45%
-18
- C3 -
-
3SXF
3
?
A:
[33-296]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Blastp_CBE
60.31
45%
-19
- C3 -
-
4TZR
1
?
A:
[33-290]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
60.31
45%
-19
- C3 -
-
5W91
1
?
A:
[33-299]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
60.20
45%
-20
- C3 -
-
5W9E
1
?
A:
[33-298]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
60.16
47%
-7
- C3 -
-
2VN9
1
KCC2D_HUMAN
B:
[6-264]
--------------------------
Y
-
Q
L
F
E
E
---
L
G
K
G
A
F
S
V
V
R
-
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
NT--------
K
-----
K
---
L
S
------
A
R
--------
D
H
----
Q
---
K
-----
L
E
---
R
---
E
A
R
I
C
R
L
L
---
K
-
H
-
P
-------
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
S
-
K
G
---
A
A
-
V
K
L
A
D
F
G
L
A
IEV
Q
-
G
--
D
--
Q
----
Q
A
-
W
-
F
G
--
F
A
--
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
---
D
P
---
Y
-
G
-
K
-
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
----
D
Q
H
-------
R
----------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
----
A
L
K
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
60.14
47%
1
- C3 -
-
2WEL
7
KCC2D_HUMAN
A:
[6-268]
--------------------------
Y
-
Q
L
F
E
E
---
L
G
K
G
A
F
S
V
V
R
-
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
NT--------
K
-----
K
---
L
S
------
A
R
--------
D
H
----
Q
---
K
-----
L
E
---
R
---
E
A
R
I
C
R
L
L
---
K
-
H
-
P
-------
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
S
-
K
G
---
A
A
-
V
K
L
A
D
F
G
L
A
IEV
Q
-
G
--
D
--
Q
----
Q
A
-
W
-
F
G
--
F
A
--
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
---
D
P
---
Y
-
G
-
K
-
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
----
D
Q
H
-------
R
----------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
----
A
L
K
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
60.13
46%
-2
- C3 -
-
5VLO
2
KCC2D_HUMAN
B:
[9-273]
--------------------
T
R
F
T
D
E
Y
-
Q
L
F
E
E
---
L
G
K
G
A
F
S
V
V
R
-
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
NT--------
K
-----
K
---
L
S
------
A
R
--------
D
H
----
Q
---
K
-----
L
E
---
R
---
E
A
R
I
C
R
L
L
---
K
-
H
-
P
-------
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
S
-
K
G
---
A
A
-
V
K
L
A
D
F
G
L
A
IEV
Q
-
G
--
D
--
Q
----
Q
A
-
W
-
F
G
--
F
A
--
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
---
D
P
---
Y
-
G
-
K
-
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
----
D
Q
H
-------
R
----------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
----
A
L
K
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
60.04
35%
-56
- C3 -
-
5M5A
1
MELK_HUMAN
A:
[3-264]
---------------
K
--
D
Y
D
E
L
L
K
Y
Y
-
E
L
H
E
T
---
I
G
T
G
G
F
A
K
V
K
-
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
----------
D
-----
K
---
N
T
------
L
G
--------
S
D
L---
P
---
R
-----
I
K
---
T
---
E
I
E
A
L
K
N
L
---
R
-
H
-
Q
-------
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
-
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
----
D
-
E
Y
---
H
K
-
L
K
L
I
D
F
G
L
C
A-----------------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
---
K
-----L
G
-
S
-
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
----
N
V
M
-------
A
----------
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
----
L
L
N
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
60.03
45%
-17
- C3 -
-
4JBV
1
?
A:
[33-290]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
60.02
41%
16
- C3 -
-
6FHB
2
DAPK1_HUMAN
A:
[20-289]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
KPK
D
T
Q
Q
A
--
L
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
60.01
39%
-56
- C3 -
-
4D9T
1
A:
[28-295]
-------------------------------
E
D
---
I
G
V
G
S
Y
S
V
C
K
-
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
----------
D
-----
K
---
S
K
----------------
R
D
----
P
---
T
-----
E
E
---
I
---
E
I
-
L
L
R
Y
G
---
Q
-
H
-
P
-------
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
----
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
-
K
----
F
-
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
-
S
-
G
N
P--
E
S
-
I
R
I
C
D
F
G
F
A
---
K
-
Q
LR
A
--
E
----
N
G
-
L
-
L
M
--
T
P
-
C
Y
T
A
N
F
V
A
P
E
V
L
------
E
------
R
---
Q
G
---
Y
-
D
-
A
-
A
-
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
NGP
D
---
D
----
T
P
E
-------
E
----------
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
-
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
----
V
L
R
H
P
W
I
----------
V
H
W
D
Q
-
L
-
P
Q
Y
Q
L
N
-
R
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
170
Blastp_CBE
60.01
40%
17
- C3 -
-
2W4K
1
DAPK1_HUMAN
A:
[17-300]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
KPK
D
T
Q
Q
A
--
L
S
R
K
A
---
S
A
V
N
M
E
-
K
F
K
K
F
-
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
Blastp_CBE
59.98
45%
-20
- C3 -
-
4MX9
1
?
A:
[34-292]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Blastp_CBE
59.97
45%
-11
- C3 -
-
3MA6
1
?
A:
[39-295]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
-------
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
---
Q
T
Y
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
59.93
45%
-17
- C3 -
-
3V5P
1
?
A:
[33-300]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
Blastp_CBE
59.92
45%
-19
- C3 -
-
4ONA
1
?
A:
[33-285]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
59.88
45%
-18
- C3 -
-
5JMS
2
?
A:
[74-343]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
59.85
45%
-20
- C3 -
-
3V5T
1
?
A:
[33-290]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
59.84
45%
-17
- C3 -
-
5JN2
1
?
A:
[74-341]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
59.84
45%
-9
- C3 -
-
5HU3
1
KCC2A_DROME
A:
[10-274]
--------------------
T
R
F
S
D
N
Y
-
D
I
K
E
E
---
L
G
K
G
A
F
S
I
V
K
-
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
NT--------
K
-----
K
---
L
T
------
A
R
--------
D
F
----
Q
---
K
-----
L
E
---
R
---
E
A
R
I
C
R
K
L
---
H
-
H
-
P
-------
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
----
F
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
-
A
-
K
G
---
A
A
-
V
K
L
A
D
F
G
L
A
---
I
-
E
--
V
--
Q
----
G
D
-
H
-
Q
A
WF
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
------
K
------
K
---
E
P
---
Y
-
G
-
K
-
S
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
----
D
Q
H
-------
R
----------
L
Y
S
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
-
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
T
A
A
E
----
A
L
K
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
593
HHSearch
59.81
41%
-11
- C3 -
-
2Y7J
1
PHKG2_HUMAN
A:
[91-364]
---------------------
E
F
Y
Q
K
Y
-
D
P
K
D
V
---
I
G
R
G
V
S
S
V
V
R
-
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
----------
E
-----
V
---
T
A
------
E
R
LSPEQLEE
V
R
----
E
---
A
-----
T
R
---
R
---
E
T
H
I
L
R
Q
V
A--
G
-
H
-
P
-------
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
----
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
-
V
----
A
-
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
-
D
N
---
M
Q
-
I
R
L
S
D
F
G
F
S
---
C
-
H
--
L
--
E
----
P
G
E
K
-
L
R
--
E
L
-
C
G
T
P
G
Y
L
A
P
E
I
L
------
K
CSMDET
H
---
P
G
---
Y
-
G
-
K
-
E
-
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
---
H
---
R
----
R
Q
I
-------
L
----------
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
-
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
----
A
L
Q
H
P
F
F
---
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
59.79
45%
-21
- C3 -
-
3UPX
1
?
A:
[33-304]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
59.74
39%
-66
- C3 -
-
4MAO
1
A:
[41-308]
-------------------------------
E
D
---
I
G
V
G
S
Y
S
V
C
K
-
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
----------
D
-----
K
---
S
K
----------------
R
D
----
P
---
T
-----
E
E
---
I
---
E
I
-
L
L
R
Y
G
---
Q
-
H
-
P
-------
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
----
V
Y
V
V
M
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
-
K
----
F
-
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
-
S
-
G
N
P--
E
S
-
I
R
I
C
D
F
G
F
A
---
K
-
Q
LR
A
--
E
----
N
G
-
L
-
L
M
--
T
P
-
C
Y
T
A
N
F
V
A
P
E
V
L
------
E
------
R
---
Q
G
---
Y
-
D
-
A
-
A
-
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
NGP
D
---
D
----
T
P
E
-------
E
----------
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
-
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
----
V
L
R
H
P
W
I
----------
V
H
W
D
Q
-
L
-
P
Q
Y
Q
L
N
-
R
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
59.73
35%
-56
- C3 -
-
5MAI
2
MELK_HUMAN
A:
[3-266]
---------------
K
--
D
Y
D
E
L
L
K
Y
Y
-
E
L
H
E
T
---
I
G
T
G
G
F
A
K
V
K
-
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
----------
D
-----
K
---
N
T
------
L
G
--------
S
D
L---
P
---
R
-----
I
K
---
T
---
E
I
E
A
L
K
N
L
---
R
-
H
-
Q
-------
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
-
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
----
D
-
E
Y
---
H
K
-
L
K
L
I
D
F
---------------------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
---
K
S
---
Y
L
G
-
S
-
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
----
N
V
M
-------
A
----------
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
----
L
L
N
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
59.70
45%
-16
- C3 -
-
5W80
1
?
A:
[33-296]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
59.67
45%
-18
- C3 -
-
3T3U
5
?
A:
[33-296]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
59.67
46%
-5
- C3 -
-
6BAB
2
KCC2D_MOUSE
A:
[12-273]
-----------------------
T
D
E
Y
-
Q
L
F
E
E
---
L
G
K
G
A
F
S
V
V
R
-
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
NT--------
K
-----
K
---
L
S
------
A
R
--------
D
H
----
Q
---
K
-----
L
E
---
R
---
E
A
R
I
C
R
L
L
---
K
-
H
-
P
-------
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
S
-
K
G
---
A
A
-
V
K
L
A
D
F
G
L
A
IEV
Q
-
G
--
D
--
Q
----
Q
A
-
W
-
F
G
--
F
A
--
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
---
D
P
---
Y
-
G
-
K
-
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
----
D
Q
H
-------
R
----------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
----
A
L
K
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
59.60
47%
-14
- C3 -
-
3HZT
9
?
A:
[12-295]
------------------------------------
L
G
S
G
A
Y
G
E
V
L
-
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
----------
K
-----
K
---
S
S
------
V
T
--------
T
T
----
S
NSG
A
-----
L
L
---
D
---
E
V
A
V
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
----
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
-
Q
----
K
-
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
R
D
---
A
L
-
I
K
I
V
D
F
G
L
S
---
A
H
F
--
E
--
V
-----------------
G
T
A
Y
Y
I
A
P
E
V
L
-------------
R
---
K
K
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
---
G
---
Q
----
T
D
Q
-------
E
----------
I
L
K
R
V
E
K
G
K
F
S
F
D
P
P
D
W
T
-
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
A
E
E
----
A
L
N
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
59.54
39%
-55
- C3 -
-
6CK3
1
MKNK2_HUMAN
A:
[19-301]
-------------------------------
D
V
---
L
G
E
G
A
H
A
R
V
Q
-
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
----------
E
-----
K
---
Q
P
------
G
H
--------
I
R
----
S
---
R
-----
V
F
---
R
---
E
V
E
M
L
Y
Q
C
---
Q
G
H
-
R
-------
N
V
L
E
L
I
E
F
F
E
E
E
D
R
----
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
-
R
----
H
-
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
-
N
-
Q
V
---
S
P
-
V
K
I
C
D
F
G
-------------------------------
G
S
A
E
Y
M
A
P
E
V
V
EAFSE-
E
------
A
---
S
I
---
Y
-
D
-
K
-
R
-
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
V
---
G
---
R
----
C
----------CGACPACQNM
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
-
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
----
V
L
Q
H
P
W
V
---
Q
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
59.52
45%
-18
- C3 -
-
4IFG
1
?
A:
[56-320]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
203
Blastp_CBE
59.51
41%
24
- C3 -
-
2Y0A
1
DAPK1_HUMAN
A:
[17-286]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
KPK
D
T
Q
Q
A
--
L
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
59.51
41%
16
- C3 -
-
6QMO
7
DAPK1_HUMAN
A:
[20-289]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
KPK
D
T
Q
Q
A
--
L
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
59.49
39%
-59
- C3 -
-
6CKI
1
MKNK2_HUMAN
A:
[19-301]
-------------------------------
D
V
---
L
G
E
G
A
H
A
R
V
Q
-
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
----------
E
-----
K
---
Q
P
------
G
H
--------
I
R
----
S
---
R
-----
V
F
---
R
---
E
V
E
M
L
Y
Q
C
---
Q
G
H
-
R
-------
N
V
L
E
L
I
E
F
F
E
E
E
D
R
----
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
-
R
----
H
-
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
-
N
-
Q
V
---
S
P
-
V
K
I
C
D
F
G
-------------------------------
G
S
A
E
Y
M
A
P
E
V
V
EAFSE-
E
------
A
---
S
I
---
Y
-
D
-
K
-
R
-
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
V
---
G
---
R
----
C
----------CGACPACQNM
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
-
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
----
V
L
Q
H
P
W
V
---
Q
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
59.45
35%
-48
- C3 -
-
6GVX
3
MELK_HUMAN
A:
[6-274]
---------------
K
--
D
Y
D
E
L
L
K
Y
Y
-
E
L
H
E
T
---
I
G
T
--
F
A
K
V
K
-
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
----------
D
-----
K
---
N
T
-----------------
D
L---
P
---
R
-----
I
K
---
T
---
E
I
E
A
L
K
N
L
---
R
-
H
-
Q
-------
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
-
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
----
D
-
E
Y
---
H
K
-
L
K
L
I
D
F
G
L
C
AKP
K
-
G
--
N
--
K
----------------
C
G
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
---
K
------
G
-
S
-
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
----
N
V
M
-------
A
----------
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
----
L
L
N
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
59.45
41%
18
- C3 -
-
2XUU
1
DAPK1_HUMAN
A:
[17-286]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
A
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
KPK
D
T
Q
Q
A
--
L
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Blastp_CBE
59.43
45%
-18
- C3 -
-
4WG5
1
?
A:
[33-285]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
Blastp_CBE
59.42
45%
-17
- C3 -
-
4MXA
1
?
A:
[34-292]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
Blastp_CBE
59.34
45%
-20
- C3 -
-
4WG3
1
?
A:
[33-290]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
59.34
45%
-16
- C3 -
-
6BFA
1
?
A:
[33-285]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Blastp_CBE
59.32
45%
-10
- C3 -
-
4IH8
1
?
A:
[56-336]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
---
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
59.31
45%
-17
- C3 -
-
4YJN
1
?
A:
[33-290]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
Blastp_CBE
59.28
45%
-19
- C3 -
-
3KU2
1
?
A:
[56-315]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
59.19
35%
-56
- C3 -
-
5MAH
2
MELK_HUMAN
A:
[3-264]
---------------
K
--
D
Y
D
E
L
L
K
Y
Y
-
E
L
H
E
T
---
I
G
T
G
G
F
A
K
V
K
-
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
----------
D
-----
K
---
N
T
------
L
G
--------
S
D
L---
P
---
R
-----
I
K
---
T
---
E
I
E
A
L
K
N
L
---
R
-
H
-
Q
-------
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
-
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
----
D
-
E
Y
---
H
K
-
L
K
L
I
D
F
G
L
C
AK----------------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
---
K
-----L
G
-
S
-
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
----
N
V
M
-------
A
----------
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
----
L
L
N
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
59.15
45%
-9
- C3 -
-
5FG8
3
KCC2A_DROME
A:
[10-274]
--------------------
T
R
F
S
D
N
Y
-
D
I
K
E
E
---
L
G
K
G
A
F
S
I
V
K
-
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
NT--------
K
-----
K
---
L
T
------
A
R
--------
D
F
----
Q
---
K
-----
L
E
---
R
---
E
A
R
I
C
R
K
L
---
H
-
H
-
P
-------
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
----
F
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
A
-
K
G
---
A
A
-
V
K
L
A
D
F
G
L
A
---
I
-
E
--
V
--
Q
----
G
D
-
H
-
Q
A
WF
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
------
K
------
K
---
E
P
---
Y
-
G
-
K
-
S
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
----
D
Q
H
-------
R
----------
L
Y
S
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
-
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
T
A
A
E
----
A
L
K
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
59.14
39%
-56
- C3 -
-
6CJH
1
MKNK2_HUMAN
A:
[19-301]
-------------------------------
D
V
---
L
G
E
G
A
H
A
R
V
Q
-
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
----------
E
-----
K
---
Q
P
------
G
H
--------
I
R
----
S
---
R
-----
V
F
---
R
---
E
V
E
M
L
Y
Q
C
---
Q
G
H
-
R
-------
N
V
L
E
L
I
E
F
F
E
E
E
D
R
----
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
-
R
----
H
-
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
-
N
-
Q
V
---
S
P
-
V
K
I
C
D
F
G
-------------------------------
G
S
A
E
Y
M
A
P
E
V
V
EAFSE-
E
------
A
---
S
I
---
Y
-
D
-
K
-
R
-
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
V
---
G
---
R
----
C
----------CGACPACQNM
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
-
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
----
V
L
Q
H
P
W
V
---
Q
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
59.13
41%
15
- C3 -
-
4B4L
3
DAPK1_HUMAN
A:
[19-288]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
KPK
D
T
Q
Q
A
--
L
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
59.10
45%
-18
- C3 -
-
4WG4
1
?
A:
[33-296]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
59.06
41%
20
- C3 -
-
4UV0
1
DAPK1_HUMAN
A:
[19-288]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
KPK
D
T
Q
Q
A
--
L
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
59.05
45%
-14
- C3 -
-
3N51
3
?
A:
[33-300]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
58.97
45%
-26
- C3 -
-
5T6I
1
?
A:
[74-360]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
-----------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
----
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
58.97
45%
-10
- C3 -
-
5VLO
2
KCC2D_HUMAN
A:
[9-273]
--------------------
T
R
F
T
D
E
Y
-
Q
L
F
E
E
---
L
G
---
F
S
V
V
R
-
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
NT--------
K
-----
K
---
L
S
------
A
R
--------
D
H
----
Q
---
K
-----
L
E
---
R
---
E
A
R
I
C
R
L
L
---
K
-
H
-
P
-------
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
S
-
K
G
---
A
A
-
V
K
L
A
D
F
G
L
A
IEV
Q
-
G
--
D
--
Q
----
Q
A
-
W
-
F
G
--
F
A
--
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
---
D
P
---
Y
-
G
-
K
-
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
----
D
Q
H
-------
R
----------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
----
A
L
K
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
58.85
41%
13
- C3 -
-
2YAK
1
DAPK1_HUMAN
A:
[17-275]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
58.85
45%
-16
- C3 -
-
3I7B
4
?
A:
[33-288]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
58.78
45%
-16
- C3 -
-
5W9R
1
?
A:
[33-304]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
58.71
35%
-58
- C3 -
-
5MAF
2
MELK_HUMAN
A:
[3-264]
---------------
K
--
D
Y
D
E
L
L
K
Y
Y
-
E
L
H
E
T
---
I
G
T
G
G
F
A
K
V
K
-
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
----------
D
-----
K
---
N
T
------
L
----------
D
L---
P
---
R
-----
I
K
---
T
---
E
I
E
A
L
K
N
L
---
R
-
H
-
Q
-------
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
----
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
-
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
----
D
-
E
Y
---
H
K
-
L
K
L
I
D
F
G
L
C
AK----------------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
---
K
-----L
G
-
S
-
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
---
D
---
D
----
N
V
M
-------
A
----------
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
----
L
L
N
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
58.69
45%
-18
- C3 -
-
3MA6
1
?
B:
[39-295]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
-----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
---
Q
T
Y
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
58.65
36%
-25
- C3 -
-
2WNT
2
B:
[26-319]
-----------------------
S
D
G
Y
-
V
V
K
E
T
---
I
G
V
G
S
Y
S
E
C
K
-
R
C
V
H
K
A
T
N
M
E
Y
A
V
K
V
I
----------
D
-----
K
---
S
K
----------------
R
D
----
P
---
S
-----
E
E
---
I
---
E
I
-
L
L
R
Y
G
---
Q
-
H
-
P
-------
N
I
I
T
L
K
D
V
Y
D
D
G
K
H
----
V
Y
L
V
T
E
L
M
R
G
G
E
L
L
D
K
I
L
R
Q
-
K
----
F
-
F
S
E
R
E
A
S
F
V
L
H
T
I
G
K
T
V
E
Y
L
H
S
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
-
S
-
G
N
---
P
E
C
L
R
I
C
D
F
G
F
A
---
K
-
Q
LR
A
--
E
----
N
G
-
L
-
L
M
--
T
P
-
C
Y
----------------
K
------
R
---
Q
G
---
Y
-
D
-
E
-
G
-
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
A
G
Y
T
P
F
A
---
N
GPS
D
----
T
P
E
-------
E
----------
I
L
T
R
I
G
S
G
K
F
T
L
S
G
G
N
W
N
-
T
V
S
E
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
K
Q
----
V
L
Q
H
P
W
V
---
T
Q
K
D
K
--
L
P
Q
S
Q
-
L
-
S
H
Q
D
L
Q
-
L
V
K
G
--
A
M
A
A
T
Y
S
A
L
N
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
58.47
41%
17
- C3 -
-
6QN4
4
DAPK1_HUMAN
A:
[20-280]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
KP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
517
Blastp_CBE
58.33
39%
-32
- C3 -
-
6C9H
2
AAPK1_HUMAN
A:
[16-318]
--------------------------
Y
-
I
L
G
D
T
---
L
G
V
G
T
F
G
K
V
K
-
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
----------
N
-----
R
---
Q
-------
K
I
--------
R
S
LDVV
G
---
K
-----
I
R
---
R
---
E
I
Q
N
L
K
L
F
---
R
-
H
-
P
-------
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
----
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
-
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
-
L
D
A
-
H
-
M
N
---
A
K
---
I
A
D
F
G
L
S
---
N
-
M
--
M
--
S
----
D
G
E
F
-
L
R
--
T
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
------
S
------
G
---
R
L
---
Y
-
A
G
P
-
E
-
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
---
D
---
D
----
H
V
P
-------
T
----------
L
F
K
K
I
C
D
G
I
--
F
Y
T
P
Q
Y
---
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
----
I
R
E
H
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
58.31
41%
14
- C3 -
-
4TXC
7
DAPK1_HUMAN
A:
[36-294]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
58.30
46%
-2
- C3 -
-
6BAB
2
KCC2D_MOUSE
B:
[14-273]
-------------------------
E
Y
-
Q
L
F
E
E
---
L
G
----
S
V
V
R
-
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
NT--------
K
-----
K
---
L
S
------
A
R
--------
D
H
----
Q
---
K
-----
L
E
---
R
---
E
A
R
I
C
R
L
L
---
K
-
H
-
P
-------
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
S
-
K
G
---
A
A
-
V
K
L
A
D
F
G
L
A
IEV
Q
-
G
--
D
--
Q
----
Q
A
-
W
-
F
G
--
F
A
--
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
---
D
P
---
Y
-
G
-
K
-
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
----
D
Q
H
-------
R
----------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
----
A
L
K
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
58.15
43%
-10
- C3 -
-
5XZV
1
?
B:
[152-466]
--------
A
S
S
M
V
--
A
--
N
K
T
G
I
F
K
D
F
S
I
I
D
E
V
---
V
G
Q
G
A
F
A
T
V
K
-
K
A
I
E
R
T
T
G
K
T
F
A
V
K
I
I
----------
S
-----
K
---
R
K
------------------M---
D
---
G
-----
V
T
---
R
---
E
L
E
V
L
Q
K
L
---
N
-
H
-
P
-------
R
I
V
R
L
K
G
F
Y
E
D
T
E
S
----
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
A
H
-
G
----
A
-
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
-
I
E
Q
-
D
-
D
P
---
V
L
-
V
K
I
T
D
F
G
L
--------------------------
T
F
-
C
G
T
L
A
Y
V
A
P
E
V
I
-------------------RNE
Y
-
S
-
S
-
L
-
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
S
---
G
---
S
----
T
Q
D
-------
Q
----------
L
Y
K
Q
I
G
R
G
S
Y
H
-
E
G
P
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
R
S
T
A
A
K
----
A
L
N
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
58.10
46%
-7
- C3 -
-
6BAB
2
KCC2D_MOUSE
C:
[14-273]
-------------------------
E
Y
-
Q
L
F
E
E
---
L
G
K
G
A
F
S
V
V
R
-
R
C
M
K
----
Q
E
Y
A
A
K
I
I
NT--------
K
-----
K
---
L
S
------
A
R
--------
D
H
----
Q
---
K
-----
L
E
---
R
---
E
A
R
I
C
R
L
L
---
K
-
H
-
P
-------
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
S
-
K
G
---
A
A
-
V
K
L
A
D
F
G
L
A
IEV
Q
-
G
--
D
--
Q
----
Q
A
-
W
-
F
G
--
F
A
--
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
---
D
P
---
Y
-
G
-
K
-
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
----
D
Q
H
-------
R
----------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
----
A
L
K
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
58.07
41%
-44
- C3 -
-
3ZXT
1
DAPK1_HUMAN
A:
[17-275]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
T----------------
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
--V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
-----------------------
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
Blastp_CBE
58.07
44%
7
- C3 -
-
3MWU
1
?
A:
[29-300]
--------------------------------
M
---
L
G
K
G
S
F
G
E
V
L
-
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
----------
N
-----
K
---
A
S
------
A
K
--------
N
K
DT--
S
---
T
-----
I
L
---
R
---
E
V
E
L
L
K
K
L
---
D
-
H
-
P
-------
N
I
M
K
L
F
E
I
L
E
D
S
S
S
----
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
-
K
----
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
-
E
-
K
D
---
C
D
-
I
K
I
I
D
F
G
L
S
---
T
C
F
--
Q
--
Q
----
N
--------
D
R
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
R
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
---
G
---
K
----
N
E
Y
-------
D
----------
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
-
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
----
C
L
E
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
Blastp_CBE
58.06
45%
-23
- C3 -
-
3HX4
3
?
A:
[57-309]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
----------------------------DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
58.05
45%
-16
- C3 -
-
4M84
1
?
A:
[33-285]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
H
F
--
E
--
A
----
S
K
-
K
-
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
57.94
41%
20
- C3 -
-
1WVY
1
DAPK1_HUMAN
A:
[17-275]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
57.91
45%
-6
- C3 -
-
5H9B
2
KCC2A_DROME
A:
[10-274]
--------------------
T
R
F
S
D
N
Y
-
D
I
K
E
E
---
L
G
K
G
A
F
S
I
V
K
-
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
NT--------
K
-----
K
---
L
T
------
A
R
--------
D
F
----
Q
---
K
-----
L
E
---
R
---
E
A
R
I
C
R
K
L
---
H
-
H
-
P
-------
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
----
F
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
A
-
K
G
---
A
A
-
V
K
L
A
D
F
G
L
A
---
I
-
E
--
V
--
Q
----
G
D
-
H
-
Q
A
WF
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
------
K
------
K
---
E
P
---
Y
-
G
-
K
-
S
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
----
D
Q
H
-------
R
----------
L
Y
S
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
-
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
T
A
A
E
----
A
L
K
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
57.82
40%
-8
- C3 -
-
4QOX
1
CDPK4_PLAF7
A:
[82-382]
------------------------------
I
K
I
---
L
G
K
G
S
F
G
E
V
I
-
L
S
R
D
K
H
T
G
H
E
Y
A
I
K
V
I
----------
S
-----
K
---
K
H
------
V
K
--------
R
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
E
L
L
K
M
L
---
D
-
H
-
I
-------
N
I
M
K
L
Y
E
F
F
E
D
N
N
Y
----
Y
Y
L
V
S
D
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
Y
E
I
D
A
A
R
I
I
K
Q
I
L
S
G
I
T
Y
M
H
K
N
N
V
V
H
R
D
L
K
P
E
N
I
L
L
E
T
K
N--
E
D
---
M
I
-
I
K
I
I
D
F
G
L
S
---
T
H
F
--
E
--
Y
----
S
---------
K
-
I
G
T
A
Y
Y
I
A
P
D
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
I
W
S
C
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
S
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
A
G
K
Y
T
F
D
L
P
Q
F
K
-
K
I
S
D
K
A
K
D
L
I
K
K
M
L
M
Y
T
S
A
V
R
I
S
A
R
D
----
A
L
E
H
E
W
I
---
K
M
M
T
S
K-----------
L
E
L
S
-
I
A
-
N
I
-
R
Q
F
Q
S
T
Q
K
L
A
Q
A
A
L
L
Y
M
G
S
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
57.62
36%
-32
- C3 -
-
2X4F
3
MYLK4_HUMAN
B:
[95-355]
-------------------------------
E
I
---
L
G
G
G
--
G
Q
V
H
-
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
----------
K
-----
T
---
R
G
------
M
K
--------
D
K
----
E
---
E
-----
V
K
---
N
---
E
I
S
V
M
N
Q
L
---
D
-
H
-
A
-------
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
----
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
-
S
----
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
--
R
-
D
A
---
K
Q
-
I
K
I
I
D
F
G
L
A
---
R
-
R
--
Y
--
K
P---
R
E
-
K
-
L
K
--
V
N
-
F
G
T
P
E
F
L
A
P
E
V
V
------
N
------
Y
---
D
F
---
V
-
S
-
F
-
P
-
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
---
G
---
D
----
N
D
A
-------
E
----------
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
-
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
----
A
L
K
H
P
W
L
---
S
D
H
K
-------
L
-
H
-
S
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
57.45
40%
1
- C3 -
-
3Q5I
1
?
A:
[28-307]
------------
R
--
K
--
K
E
G
K
I
G
E
S
Y
-
F
K
V
R
K
---
L
G
S
--
Y
G
E
V
L
-
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
----------
K
-----
K
--------------------------------KFHEE
I
Y
---
N
---
E
I
S
L
L
K
S
L
---
D
-
H
-
P
-------
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
----
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
R
-
H
----
K
-
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
N
K
-
N
-
S
L
---
L
N
-
I
K
I
V
D
F
G
L
S
---
S
F
F
--
S
--
K
----
D
Y
-
K
-
L
R
--
D
R
-
L
G
T
A
Y
Y
I
A
P
E
V
L
-------------
K
---
K
K
---
Y
-
N
-
E
-
K
-
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
---
G
---
Q
----
N
D
Q
-------
D
----------
I
I
K
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
-
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
A
E
E
----
A
L
N
S
R
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
57.43
48%
-6
- C3 -
-
2W4O
1
KCC4_HUMAN
A:
[54-341]
-----------------------------
F
F
E
V
ESE
L
G
R
G
A
T
S
I
V
Y
-
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
----------
K
-----
K
-----------------------------------------------
I
G
V
L
L
R
L
---
S
-
H
-
P
-------
N
I
I
K
L
K
E
I
F
E
T
P
T
E
----
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
-
G
----
Y
-
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
-
A
-
P
D
---
A
P
-
L
K
I
A
D
F
--------------------------------
G
T
P
G
Y
C
A
P
E
I
L
------
R
------
G
---
C
A
---
Y
-
G
-
P
-
E
-
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
---
D
---
E
----
R
G
D
-------
Q
F---------
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
-
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
----
A
L
Q
H
P
W
V
---
T
G
K
A
A
NF
V
H
M
D
-----
T
A
Q
K
K
-
L
Q
E
F
N
-
A
R
R
K
L
K
A
A
V
K
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
57.04
38%
-15
- C3 -
-
6FDY
2
ULK3_HUMAN
U:
[13-270]
--------------------------
F
-
I
L
T
E
R
---
L
G
-----
T
V
Y
K
A
Y
A
K
K
D
T
R
E
V
V
A
I
K
C
V
----------
A
-----
K
---
K
-------
S
L
--------
N
K
----
A
---
S
-----
V
E
---
N
LLT
E
I
E
I
L
K
G
I
---
R
-
H
-
P
-------
H
I
V
Q
L
K
D
F
Q
W
D
S
D
N
----
I
Y
L
I
M
E
F
C
A
G
G
D
L
S
R
F
I
H
T
R
-
R
----
I
-
L
P
E
K
V
A
R
V
F
M
Q
Q
L
A
S
A
L
Q
F
L
H
E
R
N
I
S
H
L
D
L
K
P
Q
N
I
L
-
L
S
S
-
L
-
E
K
---
P
H
-
L
K
L
A
D
F
G
F
A
---
Q
H
M
--
S
--
P
----
W
D
-
E
-
K
H
--
V
L
-
R
G
S
P
L
Y
M
A
P
E
M
V
------
C
------
Q
---
R
Q
---
Y
-
D
-
A
-
R
-
V
D
L
W
S
M
G
V
I
L
Y
E
A
L
F
G
Q
P
P
F
A
---
S
---
R
----
S
F
S
-------
E
----------
L
E
E
K
I
R
S
N
R
V
-
I
E
L
P
L
R
P
-
L
L
S
R
D
C
R
D
L
L
Q
R
L
L
E
R
D
P
S
R
R
I
S
F
Q
D
----
F
F
A
H
P
W
V
---
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
591
HHSearch
56.94
37%
-38
- C3 -
-
2X4F
4
MYLK4_HUMAN
A:
[89-349]
------------------------
Y
T
V
-
S
K
T
E
I
---
L
-----
G
Q
V
H
-
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
----------
K
-----
T
---
R
G
------
M
K
--------
D
K
----
E
---
E
-----
V
K
---
N
---
E
I
S
V
M
N
Q
L
---
D
-
H
-
A
-------
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
----
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
Y
----
N
-
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
--
R
-
D
A
---
K
Q
-
I
K
I
I
D
F
G
L
A
---
R
-
R
--
Y
--
K
----
P
R
E
K
-
L
K
--
V
N
-
F
G
T
P
E
F
L
A
P
E
V
V
------
N
------
Y
---
D
F
---
V
-
S
-
F
-
P
-
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
---
G
---
D
----
N
D
A
-------
E
----------
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
-
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
----
A
L
K
H
P
W
L
---
S
D
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
56.94
41%
16
- C3 -
-
5AV2
1
DAPK1_HUMAN
A:
[17-275]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
------
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
56.93
41%
16
- C3 -
-
5AUX
1
DAPK1_HUMAN
A:
[17-275]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
------
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
56.87
44%
12
- C3 -
-
2WEI
1
?
A:
[29-280]
--------------------------------
M
---
L
G
K
G
S
F
G
E
V
L
-
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
----------
N
-----
K
---
A
S
------
A
K
--------
N
K
DT--
S
---
T
-----
I
L
---
R
---
E
V
E
L
L
K
K
L
---
D
-
H
-
P
-------
N
I
M
K
L
F
E
I
L
E
D
S
S
S
----
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
-
K
----
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
-
E
-
K
D
---
C
D
-
I
K
I
I
D
F
G
L
S
---
T
C
F
--
Q
--
Q
----
N
T
-
K
-
M
K
--
D
R
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
R
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
---
G
---
K
----
N
E
Y
-------
D
----------
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
-
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
----
C
L
E
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
56.80
44%
16
- C3 -
-
5VJA
3
DAPK3_HUMAN
D:
[11-269]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
R
-
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
----------
K
-----
K
RRL
S
-----------------------
V
---
S
REE--
I
E
---
R
---
E
V
N
I
L
R
E
I
---
R
-
H
-
P
-------
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
---
E
K
-
E
----
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
---V
P
N
---
P
R
-
I
K
L
I
D
F
G
I
A
H--
K
-
I
--
E
--
A
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
----
T
K
Q
-------
E
----------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
----
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
56.75
44%
12
- C3 -
-
3BHY
1
DAPK3_HUMAN
A:
[11-269]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
R
-
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
----------
K
-----
K
RRL
S
S
------
S
R
--------
R
G
----
V
---
S
REE--
I
E
---
R
---
E
V
N
I
L
R
E
I
---
R
-
H
-
P
-------
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
-
N
V
P
N
---
P
R
-
I
K
L
I
D
F
G
I
A
H--
K
-
I
--
E
-------------------
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
----
T
K
Q
-------
E
----------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
----
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
56.67
41%
17
- C3 -
-
2W4J
1
DAPK1_HUMAN
A:
[17-275]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
56.66
41%
13
- C3 -
-
5AUY
1
DAPK1_HUMAN
A:
[17-275]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
------
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
56.60
41%
16
- C3 -
-
5AV3
1
DAPK1_HUMAN
A:
[17-275]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
------
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
56.46
39%
-5
- C3 -
-
2Y7J
1
PHKG2_HUMAN
C:
[82-364]
-------
E
L
P
D
W
A
--
A
--
A
K
E
F
Y
Q
K
-
Y
-
D
P
K
D
V
---
I
G
R
G
V
S
S
V
V
R
-
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
EVTAE-----
R
-----
L
---
S
P
------
E
Q
--------
L
E
----
E
---
V
-----
R
E
ATR
R
---
E
T
H
I
L
R
Q
V
---
A
G
H
-
P
-------
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
----
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
-
V
----
A
-
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
-
D
N
---
M
Q
-
I
R
L
S
D
F
G
F
S
C--
H
-
L
--
E
--
P
----
G
E
-
K
-
L
R
--
E
L
-
C
G
T
P
G
Y
L
A
P
E
I
L
KCSMDE
T
------
H
---
P
G
---
Y
-
G
-
K
-
E
-
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
---
H
---
R
----
R
Q
I
-------
L
----------
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
-
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
----
A
L
Q
H
P
F
F
---
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
56.41
44%
14
- C3 -
-
5VJA
2
DAPK3_HUMAN
C:
[11-269]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
R
-
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
----------
K
-----
K
RRL
S
S
-----------------
G
----
V
---
S
REE--
I
E
---
R
---
E
V
N
I
L
R
E
I
---
R
-
H
-
P
-------
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
--
E
K
-
E
----
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
---V
P
N
---
P
R
-
I
K
L
I
D
F
G
I
A
H--
K
-
I
--
E
--
A
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
----
T
K
Q
-------
E
----------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
----
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
56.40
41%
18
- C3 -
-
5AUW
1
DAPK1_HUMAN
A:
[17-275]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
56.37
41%
14
- C3 -
-
5AV0
1
DAPK1_HUMAN
A:
[17-275]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
------
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
56.34
38%
10
- C3 -
-
2PHK
2
PHKG1_RABIT
A:
[10-274]
-------------------------------
E
I
---
L
G
R
G
V
S
S
V
V
R
-
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
DVTGGGSFSA
E
-----
E
---
V
Q
------
E
L
--------
R
E
----
A
---
T
-----
L
K
-------
E
V
D
I
L
R
K
V
---
S
G
H
-
P
-------
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
----
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
-
V
----
T
-
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
-
D
D
---
M
N
-
I
K
L
T
D
F
G
F
S
C--
Q
-
L
--
D
--
P
----
G
E
-
K
-
L
R
--
E
V
-
C
G
T
P
S
Y
L
A
P
E
I
I
------
E
CSMNDN
H
---
P
G
---
Y
-
G
-
K
-
E
-
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
---
H
---
R
----
K
Q
M
-------
L
----------
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
-
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
----
A
L
A
H
P
F
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
56.34
41%
13
- C3 -
-
4PF4
6
DAPK1_HUMAN
A:
[18-276]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
56.29
39%
-8
- C3 -
-
2Y7J
1
PHKG2_HUMAN
B:
[82-364]
-------
E
L
P
D
W
A
--
A
--
A
K
E
F
Y
Q
K
-
Y
-
D
P
K
D
V
---
I
G
R
G
V
S
S
V
V
R
-
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
EVTA----------------
S
P
------
E
Q
--------
L
E
----
E
---
V
-----
R
E
ATR
R
---
E
T
H
I
L
R
Q
V
---
A
G
H
-
P
-------
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
----
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
-
V
----
A
-
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
-
D
N
---
M
Q
-
I
R
L
S
D
F
G
F
S
C--
H
-
L
--
E
--
P
----
G
E
-
K
-
L
R
--
E
L
-
C
G
T
P
G
Y
L
A
P
E
I
L
KCSMDE
T
------
H
---
P
G
---
Y
-
G
-
K
-
E
-
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
---
H
---
R
----
R
Q
I
-------
L
----------
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
-
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
----
A
L
Q
H
P
F
F
---
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
56.23
44%
12
- C3 -
-
5A6O
2
DAPK3_HUMAN
B:
[11-269]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
R
-
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
----------
K
-----
K
RRL
S
S
------
S
R
--------
R
G
----
V
---
S
REE--
I
E
---
R
---
E
V
N
I
L
R
E
I
---
R
-
H
-
P
-------
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
-
N
V
P
N
---
P
R
-
I
K
L
I
D
F
G
I
A
H--
K
-
I
--
E
-------------
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
----
T
K
Q
-------
E
----------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
----
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
56.22
41%
13
- C3 -
-
5AUU
1
DAPK1_HUMAN
A:
[17-275]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
---
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
56.15
41%
19
- C3 -
-
5AUT
1
DAPK1_HUMAN
A:
[17-275]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
---
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
56.14
41%
17
- C3 -
-
5AUZ
1
DAPK1_HUMAN
A:
[17-275]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
---
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
56.10
41%
17
- C3 -
-
5AUV
1
DAPK1_HUMAN
A:
[17-275]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
------
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
240
Blastp_CBE
56.08
41%
15
- C3 -
-
5AV4
1
DAPK1_HUMAN
A:
[17-275]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
---
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
56.08
44%
10
- C3 -
-
5A6N
1
DAPK3_HUMAN
B:
[11-269]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
R
-
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
----------
K
-----
K
RRL
S
S
------
S
R
--------
R
G
----
V
---
S
REE--
I
E
---
R
---
E
V
N
I
L
R
E
I
---
R
-
H
-
P
-------
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
-
N
V
P
N
---
P
R
-
I
K
L
I
D
F
G
I
A
H--
K
-
I
--
E
-------------
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
----
T
K
Q
-------
E
----------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
----
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
56.02
44%
6
- C3 -
-
5VJA
2
DAPK3_HUMAN
A:
[11-269]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
R
-
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
----------
K
-----
K
R-----------
R
--------
R
G
----
V
---
S
REE--
I
E
---
R
---
E
V
N
I
L
R
E
I
---
R
-
H
-
P
-------
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
-
N
V
P
N
---
P
R
-
I
K
L
I
D
F
G
I
A
H--
K
-
I
--
E
--
A
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
----
T
K
Q
-------
E
----------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
----
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
56.00
38%
9
- C3 -
-
1QL6
1
PHKG1_RABIT
A:
[23-287]
-------------------------------
E
I
---
L
G
R
G
V
S
S
V
V
R
-
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
DVTGGGSFSA
E
-----
E
---
V
Q
------
E
L
--------
R
E
----
A
---
T
-----
L
K
-------
E
V
D
I
L
R
K
V
---
S
G
H
-
P
-------
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
----
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
-
V
----
T
-
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
-
D
D
---
M
N
-
I
K
L
T
D
F
G
F
S
C--
Q
-
L
--
D
--
P
----
G
E
-
K
-
L
R
--
S
V
-
C
G
T
P
S
Y
L
A
P
E
I
I
------
E
CSMNDN
H
---
P
G
---
Y
-
G
-
K
-
E
-
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
---
H
---
R
----
K
Q
M
-------
L
----------
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
-
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
----
A
L
A
H
P
F
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
56.00
39%
1
- C3 -
-
2Y7J
1
PHKG2_HUMAN
A:
[82-364]
-------
E
L
P
D
W
A
--
A
--
A
K
E
F
Y
Q
K
-
Y
-
D
P
K
D
V
---
I
G
R
G
V
S
S
V
V
R
-
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
EVTAE-----
R
-----
L
---
S
P
------
E
Q
--------
L
E
----
E
---
V
-----
R
E
ATR
R
---
E
T
H
I
L
R
Q
V
---
A
G
H
-
P
-------
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
----
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
-
V
----
A
-
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
-
D
N
---
M
Q
-
I
R
L
S
D
F
G
F
S
C--
H
-
L
--
E
--
P
----
G
E
-
K
-
L
R
--
E
L
-
C
G
T
P
G
Y
L
A
P
E
I
L
KCSMDE
T
------
H
---
P
G
---
Y
-
G
-
K
-
E
-
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
---
H
---
R
----
R
Q
I
-------
L
----------
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
-
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
----
A
L
Q
H
P
F
F
---
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
55.92
39%
-35
- C3 -
-
2JBO
1
MAPK2_HUMAN
A:
[30-293]
-------------------------------
Q
V
---
L
G
L
G
I
N
G
K
V
L
-
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
----------
Q
-----
D
---
C
P
K-----
A
R
--------
R
E
----
V
---
E
-----
L
H
-----------
W
R
A
S
---
Q
-
C
-
P
-------
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
GRKC
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
-
G
DQ--
A
-
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
-
R
-
P
N
---
A
I
-
L
K
L
T
D
F
G
F
A
---
K
E
T
--
T
-------------------
C
Y
T
P
Y
Y
V
A
P
E
V
L
------
G
------
P
---
E
K
---
Y
-
D
-
K
-
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
---
S
---
N
HGLA
I
S
P
-------
G
----------
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
-
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
----
F
M
N
H
P
W
I
---
M
Q
S
T
K
--
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
55.92
44%
14
- C3 -
-
5A6O
3
DAPK3_HUMAN
A:
[11-269]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
R
-
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
----------
K
-----
K
RRL
S
S
------
S
R
--------
R
G
----
V
---
S
REE--
I
E
---
R
---
E
V
N
I
L
R
E
I
---
R
-
H
-
P
-------
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
-
N
V
P
N
---
P
R
-
I
K
L
I
D
F
G
I
A
H--
K
-
I
--
E
-------------
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
----
T
K
Q
-------
E
----------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
----
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
55.88
38%
12
- C3 -
-
1PHK
1
PHKG1_RABIT
A:
[23-287]
-------------------------------
E
I
---
L
G
R
G
V
S
S
V
V
R
-
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
DVTGGGSFSA
E
-----
E
---
V
Q
------
E
L
--------
R
E
----
A
---
T
-----
L
K
-------
E
V
D
I
L
R
K
V
---
S
G
H
-
P
-------
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
----
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
-
V
----
T
-
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
-
D
D
---
M
N
-
I
K
L
T
D
F
G
F
S
C--
Q
-
L
--
D
--
P
----
G
E
-
K
-
L
R
--
E
V
-
C
G
T
P
S
Y
L
A
P
E
I
I
------
E
CSMNDN
H
---
P
G
---
Y
-
G
-
K
-
E
-
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
---
H
---
R
----
K
Q
M
-------
L
----------
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
-
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
----
A
L
A
H
P
F
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
55.71
44%
16
- C3 -
-
5A6N
4
DAPK3_HUMAN
A:
[11-269]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
R
-
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
----------
K
-----
K
RRL
S
S
------
S
R
--------
R
G
----
V
---
S
REE--
I
E
---
R
---
E
V
N
I
L
R
E
I
---
R
-
H
-
P
-------
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
-
N
V
P
N
---
P
R
-
I
K
L
I
D
F
G
I
A
H--
K
-
I
--
E
--
A
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
----
T
K
Q
-------
E
----------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
----
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Blastp_CBE
55.39
44%
6
- C3 -
-
4Y5Q
1
?
A:
[29-300]
--------------------------------
M
---
L
G
K
G
S
F
G
E
V
L
-
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
----------
N
-----
K
---
A
S
------
A
K
--------
N
K
DT--
S
---
T
-----
I
L
---
R
---
E
V
E
L
L
K
K
L
---
D
-
H
-
P
-------
N
I
M
K
L
F
E
I
L
E
D
S
S
S
----
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
-
K
----
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
-
E
-
K
D
---
C
D
-
I
K
I
I
D
F
G
L
S
---
T
C
F
--
Q
--
Q
----
N
T
-------
D
R
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
R
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
---
G
---
K
----
N
E
Y
-------
D
----------
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
-
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
----
C
L
E
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
55.25
39%
19
- C3 -
-
2Y7J
1
PHKG2_HUMAN
D:
[82-364]
-------
E
L
P
D
W
A
--
A
--
A
K
E
F
Y
Q
K
-
Y
-
D
P
K
D
V
---
I
G
R
G
V
S
S
V
V
R
-
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
EV--------
R
-----
L
---
S
P
------
E
Q
--------
L
E
----
E
---
V
-----
R
E
ATR
R
---
E
T
H
I
L
R
Q
V
---
A
G
H
-
P
-------
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
----
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
-
V
----
A
-
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
-
D
N
---
M
Q
-
I
R
L
S
D
F
G
F
S
C--
H
-
L
--
E
--
P
----
G
E
-
K
-
L
R
--
E
L
-
C
G
T
P
G
Y
L
A
P
E
I
L
KCSMDE
T
------
H
---
P
G
---
Y
-
G
-
K
-
E
-
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
---
H
---
R
----
R
Q
I
-------
L
----------
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
-
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
----
A
L
Q
H
P
F
F
---
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
Blastp_CBE
55.21
44%
5
- C3 -
-
3NCG
1
?
A:
[29-317]
--------------------------------
M
---
L
G
K
G
S
F
G
E
V
L
-
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
----------
N
-----
K
---
A
S
------
A
K
--------
N
K
DT--
S
---
T
-----
I
L
---
R
---
E
V
E
L
L
K
K
L
---
D
-
H
-
P
-------
N
I
M
K
L
F
E
I
L
E
D
S
S
S
----
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
-
K
----
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
-
E
-
K
D
---
C
D
-
I
K
I
I
D
F
G
L
S
---
T
C
F
--
Q
--
Q
----
N
T
----------
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
R
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
---
G
---
K
----
N
E
Y
-------
D
----------
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
-
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
----
C
L
E
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
55.08
44%
18
- C3 -
-
5VJA
2
DAPK3_HUMAN
B:
[11-269]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
R
-
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
----------
K
-----
K
------------
R
--------
R
G
----
V
---
S
REE--
I
E
---
R
---
E
V
N
I
L
R
E
I
---
R
-
H
-
P
-------
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
-
N
V
P
N
---
P
R
-
I
K
L
I
D
F
G
I
A
H--
K
-
I
--
E
--
A
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
----
T
K
Q
-------
E
----------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
----
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
54.95
39%
-30
- C3 -
-
3AQV
1
AAPK2_HUMAN
A:
[13-265]
--------------------------
Y
-
V
L
G
D
T
---
L
G
V
G
T
F
G
K
V
K
-
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
----------
N
-----
R
---
Q
-------
K
I
--------
R
S
LDVV
G
---
K
-----
I
K
---
R
---
E
I
Q
N
L
K
L
F
---
R
-
H
-
P
-------
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
----
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
-
G
----
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
-
L
D
A
-
H
-
M
N
---
A
K
---
I
A
D
F
G
L
S
---
N
-
M
--
M
--
S
----
D
G
E
F
-
L
---------
P
N
Y
A
A
P
E
V
I
------
S
------
G
---
R
L
---
Y
-
A
-
G
P
E
-
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
---
D
---
E
----
H
V
P
-------
T
----------
L
F
K
K
I
R
G
G
V
--
F
Y
I
P
E
Y
---
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
----
I
R
E
H
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
54.92
44%
17
- C3 -
-
3BQR
4
DAPK3_HUMAN
A:
[11-269]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
R
-
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
----------
K
-----
K
RRL
S
S
------
S
R
--------
R
G
----
V
---
S
REE--
I
E
---
R
---
E
V
N
I
L
R
E
I
---
R
-
H
-
P
-------
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
-
N
V
P
N
---
P
R
-
I
K
L
I
D
F
G
I
A
H--
K
-
I
--
E
--
A
----
G
N
-------
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
----
T
K
Q
-------
E
----------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
----
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
54.24
41%
25
- C3 -
-
6AAR
1
DAPK1_HUMAN
A:
[17-275]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-------------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
--
F
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
54.21
39%
-12
- C3 -
-
4CZT
4
CIPKN_ARATH
D:
[19-272]
------------------------------------
L
G
E
G
T
F
A
K
V
K
-
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
----------
D
-----
K
---
E
K
------
V
L
--------
K
N
KMI-
A
---
Q
-----
I
K
---
R
---
E
I
S
T
M
K
L
I
---
K
-
H
-
P
-------
N
V
I
R
M
F
E
V
M
A
S
K
T
K
----
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
-
G
----
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
----
D
-
A
N
---
G
A
-
L
K
V
S
D
F
G
L
S
---
A
-
L
--
P
--
Q
QVRE
D
G
-
L
-
L
H
--
T
T
-
C
G
T
P
N
Y
V
A
P
E
V
I
------
N
------
N
---
K
G
---
Y
-
D
-
G
-
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
---
D
---
S
----
N
L
T
-------
S
----------
L
Y
K
K
I
F
K
A
--
E
F
T
C
P
P
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
----
V
I
E
N
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
Blastp_CBE
53.89
43%
-32
- C3 -
-
4PDS
1
RAD53_YEAST
B:
[26-305]
--------------------
T
G
I
F
K
D
F
S
I
I
------------
A
T
V
K
-
K
A
I
E
R
T
T
G
K
T
F
S
V
K
I
I
------------------------------------------------------
V
T
---
R
---
E
L
E
V
L
Q
K
L
---
N
-
H
-
P
-------
R
I
V
R
L
K
G
F
Y
---------
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
A
H
-
G
----
A
-
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
-
I
E
Q
-
D
-
D
P
---
V
L
-
V
K
I
T
A
F
G
L
A
---
K
-
V
------------------------
T
L
A
Y
V
A
P
E
V
I
-------------------NE-
Y
-
S
-
S
-
L
-
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
S
---
G
---
S
----
T
Q
D
-------
Q
----------
L
Y
K
Q
I
G
R
G
S
Y
H
-
E
G
P
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
R
S
T
A
A
K
----
A
L
N
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
351
Blastp_CBE
53.82
39%
-13
- C3 -
-
4CZT
3
CIPKN_ARATH
A:
[19-270]
------------------------------------
L
G
E
G
T
F
A
K
V
K
-
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
----------
D
-----
K
---
E
K
------
V
L
--------
K
N
KMI-
A
---
Q
-----
I
K
---
R
---
E
I
S
T
M
K
L
I
---
K
-
H
-
P
-------
N
V
I
R
M
F
E
V
M
A
S
K
T
K
----
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
-
G
----
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
----
D
-
A
N
---
G
A
-
L
K
V
S
D
F
G
L
S
---
A
-
L
--
P
--
Q
QVRE
D
G
-
L
-
L
H
--
T
T
-
C
G
T
P
N
Y
V
A
P
E
V
I
------
N
------
N
---
K
G
---
Y
-
D
-
G
-
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
---
D
---
S
----
N
L
T
-------
S
----------
L
Y
K
K
I
F
K
A
--
E
F
T
C
P
P
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
----
V
I
E
N
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
343
Blastp_CBE
53.72
37%
-17
- C3 -
-
3KN5
1
B:
[19-280]
------------------------------------
L
G
E
G
S
F
S
I
C
R
-
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
I
----------
S
-----
K
---
R
-----------------
M
E
----
A
---
N
-----
T
Q
---
K
---
E
I
T
A
L
K
L
C
---
E
G
H
-
P
-------
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
----
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
K
K
K
-
K
----
H
-
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
---------
L
E
-
I
K
I
I
D
F
G
F
A
---
R
-
L
--
K
PP----------------------------------------------
N
G
---
Y
-
D
-
E
-
S
-
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
Q
---
S
---
H
----
D
R
S
LTCTSAV
E
----------
I
M
K
K
I
K
K
G
D
F
S
F
E
G
E
A
W
K
-
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
M
S
G
----
L
R
Y
N
E
W
L
---
Q
D
G
S
Q
--
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
53.64
41%
17
- C3 -
-
3ZXT
1
DAPK1_HUMAN
B:
[17-275]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSRR-
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
---------------------
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
-
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
----
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
Blastp_CBE
53.32
43%
-34
- C3 -
-
4PDS
1
RAD53_YEAST
A:
[26-304]
--------------------
T
G
I
F
K
D
F
S
I
I
D
E
V
----------
T
V
K
-
K
A
I
E
R
T
T
G
K
T
F
S
V
K
I
I
------------------------------------------------------
V
T
---
R
---
E
L
E
V
L
Q
K
L
---
N
-
H
-
P
-------
R
I
V
R
L
K
G
F
Y
---
E
S
----
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
A
H
-
G
----
A
-
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
-
I
E
Q
-
D
-
D
P
---
V
L
-
V
K
I
T
A
F
G
L
A
---
K
-
V
--------------------------
A
Y
V
A
P
E
V
I
------
R
------------RNE
Y
-
S
-
S
-
L
-
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
S
---
G
---
S
----
T
Q
D
-------
Q
----------
L
Y
K
Q
I
G
R
G
S
Y
H
-
E
G
P
L
K
D
F
R
I
S
E
E
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
R
S
T
A
A
K
----
A
L
N
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
53.25
37%
-31
- C3 -
-
3KN5
1
KS6A5_HUMAN
A:
[19-280]
------------------------------------
L
G
E
G
S
F
S
I
C
R
-
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
I
----------
S
-----
K
---
R
-----------------
M
E
----
A
---
N
-----
T
Q
---
K
---
E
I
T
A
L
K
L
C
---
E
G
H
-
P
-------
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
----
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
K
K
K
-
K
----
H
-
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
---------
L
E
-
I
K
I
I
D
F
G
F
A
---
R
-
L
--
K
PP----------------------------------------------
N
G
---
Y
-
D
-
E
-
S
-
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
Q
---------------CTSAV--
E
----------
I
M
K
K
I
K
K
G
D
F
S
F
E
G
E
A
W
K
-
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
M
S
G
----
L
R
Y
N
E
W
L
---
Q
D
G
S
Q
--
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
53.15
41%
9
- C3 -
-
3ZXT
1
DAPK1_HUMAN
C:
[17-275]
-------------------------------
E
E
---
L
--
G
Q
F
A
V
V
K
-
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
TKSSRR
G
V
--------
S
R
----
E
---
D
-----
I
E
---
R
---
E
V
S
I
L
K
E
I
---
Q
-
H
-
P
-------
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
----
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
N
V
P
K
---
P
R
-
I
K
I
I
D
F
G
L
A
H--
K
-
I
--
D
----------------------
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
D
----
T
K
Q
-------
E
----------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
-
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
----
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
53.04
44%
-24
- C3 -
-
3I7C
1
?
A:
[33-288]
--------------------------------
V
---
L
G
K
G
S
F
G
E
V
I
-
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
----------
S
-----
K
---
R
Q
------
V
K
--------
Q
K
----
T
DKE
S
-----
L
L
---
R
---
E
V
Q
L
L
K
Q
L
---
D
-
H
-
P
-------
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
----
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
-
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
-
S
-
K
D
---
A
N
-
I
R
I
I
D
F
G
L
S
---
T
-
H
--
F
--
E
----
A
S
-
K
-
K
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
-------------
H
---
G
T
---
Y
-
D
-
E
-
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
---
G
---
A
----
N
E
Y
-------
D
----------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
-
K
V
S
E
S
A
K
D
L
I
R
K
L
T
Y
V
-
P
S
-
R
I
S
A
R
D
----
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
358
Blastp_CBE
52.76
38%
-12
- C3 -
-
4CZU
3
CIPKN_ARATH
C:
[19-273]
------------------------------------
L
G
E
G
T
F
A
K
V
K
-
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
----------
D
-----
K
---
E
K
------
V
L
--------
K
N
KMI-
A
---
Q
-----
I
K
---
R
---
E
I
S
T
M
K
L
I
---
K
-
H
-
P
-------
N
V
I
R
M
F
E
V
M
A
S
K
T
K
----
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
-
G
----
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
----
D
-
A
N
---
G
A
-
L
K
V
S
D
F
G
L
S
---
A
-
L
--
P
--
Q
QVRE
D
G
-
L
-
L
H
--
D
T
-
C
G
T
P
N
Y
V
A
P
E
V
I
------
N
------
N
---
K
G
---
Y
-
D
-
G
-
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
---
D
---
S
----
N
L
T
-------
S
----------
L
Y
K
K
I
F
K
A
--
E
F
T
C
P
P
W
---
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
----
V
I
E
N
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
52.70
35%
28
- C3 -
-
2F7X
1
KAPCA_BOVIN
E:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
-----
G
-
R
-
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
52.69
35%
23
- C3 -
-
2F7E
1
KAPCA_BOVIN
E:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
-----
G
-
R
-
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
52.49
39%
-39
- C3 -
-
6BX6
1
AAPK2_HUMAN
A:
[13-265]
--------------------------
Y
-
V
L
G
D
T
---
L
G
V
G
T
F
G
K
V
K
-
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
----------
N
-----
R
---
Q
-------
K
I
--------
R
S
LDVV
G
---
K
-----
I
K
---
R
---
E
I
Q
N
L
K
L
F
---
R
-
H
-
P
-------
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
----
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
-
G
----
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
-
L
D
A
-
H
-
M
N
---
A
K
---
I
A
D
F
G
L
S
--------------------------------
N
Y
A
A
P
E
------------------------
Y
-
A
-
G
P
E
-
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
---
D
---
E
----
H
V
P
-------
T
----------
L
F
K
K
I
R
G
G
V
--
F
Y
I
P
E
Y
---
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
----
I
R
E
H
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
52.33
39%
-32
- C3 -
-
6B2E
2
AAPK2_HUMAN
A:
[29-381]
--------------------------
Y
-
V
L
G
D
T
---
L
G
V
G
T
F
G
K
V
K
-
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
----------
N
-----
R
---
Q
-------
K
I
--------
R
S
LDVV
G
---
K
-----
I
K
---
R
---
E
I
Q
N
L
K
L
F
---
R
-
H
-
P
-------
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
----
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
-
G
----
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
-
L
D
A
-
H
-
M
N
---
A
K
---
I
A
D
F
G
L
S
---
N
-
M
--
M
--
S
----
D
G
-
E
-
F
L
--
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
------
S
------
G
---
R
L
---
Y
-
A
-
G
P
E
-
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
---
D
---
E
----
H
V
P
-------
T
----------
L
F
K
K
I
R
G
G
V
--
F
Y
I
P
E
Y
---
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
----
I
R
E
H
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
314
Blastp_CBE
52.17
39%
-16
- C3 -
-
2PZY
1
MAPK2_HUMAN
C:
[28-291]
-------------------------------
Q
V
---
L
G
L
G
I
N
G
K
V
L
-
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
----------
Q
-----
D
---
C
P
K-----
A
R
--------
R
E
----
V
---
E
-----
L
H
-----------
W
R
A
S
---
Q
-
C
-
P
-------
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
GRKC
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
-
G
DQ--
A
-
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
-
R
-
P
N
---
A
I
-
L
K
L
T
D
F
G
F
A
---
K
E
T
------------------------
T
P
Y
Y
V
A
P
E
V
L
------
G
------
P
---
E
K
---
Y
-
D
-
K
-
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
---
S
---
N
HGLA
I
S
P
-------
G
----------
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
-
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
----
F
M
N
H
P
W
I
---
M
Q
S
T
K
--
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
52.12
35%
23
- C3 -
-
2OH0
1
KAPCA_BOVIN
E:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
-----
G
-
R
-
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
449
Blastp_CBE
51.96
35%
26
- C3 -
-
2UZW
1
KAPCA_BOVIN
E:
[5-267]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
----
R
--
V
----
K
G
-
R
-
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
51.76
39%
-6
- C3 -
-
1NY3
1
MAPK2_HUMAN
A:
[68-331]
-------------------------------
Q
V
---
L
G
L
G
I
N
G
K
V
L
-
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
----------
Q
-----
D
---
C
P
------
K
A
--------
R
--------------------
R
---
E
V
E
L
H
W
R
A
---
S
-
Q
C
P
-------
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
GRKC
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
----------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
-
R
-
P
N
---
A
I
-
L
K
L
T
D
F
G
F
A
---
K
E
T
--
T
--
S
----
H
--------------
P
Y
Y
V
A
P
E
V
L
------
G
------
P
---
E
K
---
Y
-
D
-
K
-
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
---
S
------------------
G
----------
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
-
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
----
F
M
N
H
P
W
I
---
M
Q
S
T
K
--
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
51.57
39%
-5
- C3 -
-
2PZY
1
MAPK2_HUMAN
A:
[28-291]
-------------------------------
Q
V
---
L
G
L
G
I
N
G
K
V
L
-
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
----------
Q
-----
D
---
C
P
K-----
A
R
--------
R
E
----
V
---
E
-----
L
H
-----------
W
R
A
S
---
Q
-
C
-
P
-------
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
GRKC
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
------
A
-
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
-
R
-
P
N
---
A
I
-
L
K
L
T
D
F
G
F
A
---
K
E
T
------------------------
T
P
Y
Y
V
A
P
E
V
L
------
G
------
P
---
E
K
---
Y
-
D
-
K
-
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
---
S
---
N
HGLA
I
S
P
-------
G
----------
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
-
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
----
F
M
N
H
P
W
I
---
M
Q
S
T
K
--
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
523
Blastp_CBE
51.53
39%
-21
- C3 -
-
5KQ5
2
?
A:
[18-399]
--------------------------
Y
-
I
L
G
D
T
---
L
G
V
G
T
F
G
K
V
K
-
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
----------
N
-----
R
---
Q
-------
K
I
--------
R
S
LDVV
G
---
K
-----
I
R
---
R
---
E
I
Q
N
L
K
L
F
---
R
-
H
-
P
-------
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
----
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
-
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
-
L
D
A
-
H
-
M
N
---
A
K
---
I
A
D
F
G
L
S
---
N
-
M
--
M
--
S
----
D
G
-
E
-
F
L
--
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
------
S
------
G
---
R
L
---
Y
-
A
G
P
-
E
-
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
---
D
---
D
----
H
V
P
-------
T
----------
L
F
K
K
I
C
D
G
I
--
F
Y
T
P
Q
Y
---
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
----
I
R
E
H
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
51.45
35%
27
- C3 -
-
2OJF
1
KAPCA_BOVIN
E:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
-----
G
-
R
-
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
51.44
46%
2
- C3 -
-
6BAB
1
KCC2D_MOUSE
D:
[10-273]
---------------------
R
F
-
D
E
Y
-
Q
L
F
E
E
---
L
G
K
G
A
F
S
V
V
R
-
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
NT--------
K
-----
K
---
L
S
------
A
R
--------
D
H
----
Q
---
K
-----
L
E
---
R
---
E
A
R
I
C
R
L
L
---
K
-
H
-
P
-------
N
I
V
R
L
H
D
S
I
S
E
E
G
F
----
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
-
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
S
-
K
G
---
A
A
-
V
K
L
A
D
F
G
L
A
IEV
Q
-
G
--
D
--
Q
----
Q
A
-
W
-
F
G
--
F
A
--
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
---
D
P
---
Y
-
G
-
K
-
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
---
D
---
E
----
D
Q
H
-------
R
----------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
-
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
----
A
L
K
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
51.43
35%
28
- C3 -
-
2UZU
1
KAPCA_BOVIN
E:
[5-267]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
----
R
--
V
----
K
G
-
R
-
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
51.01
39%
-20
- C3 -
-
6E4U
2
AAPK1_RAT
A:
[18-397]
--------------------------
Y
-
I
L
G
D
T
---
L
G
V
G
T
F
G
K
V
K
-
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
----------
N
-----
R
---
Q
-------
K
I
--------
R
S
LDVV
G
---
K
-----
I
R
---
R
---
E
I
Q
N
L
K
L
F
---
R
-
H
-
P
-------
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
----
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
-
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
-
L
D
A
-
H
-
M
N
---
A
K
---
I
A
D
F
G
L
S
---
N
-
M
--
M
--
S
----
D
G
-
E
-
F
L
--
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
------
S
------
G
---
R
L
---
Y
-
A
G
P
-
E
-
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
---
D
---
D
----
H
V
P
-------
T
----------
L
F
K
K
I
C
D
G
I
--
F
Y
T
P
Q
Y
---
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
----
I
R
E
H
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
520
Blastp_CBE
50.92
39%
-19
- C3 -
-
6E4T
2
?
A:
[18-401]
--------------------------
Y
-
I
L
G
D
T
---
L
G
V
G
T
F
G
K
V
K
-
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
----------
N
-----
R
---
Q
-------
K
I
--------
R
S
LDVV
G
---
K
-----
I
R
---
R
---
E
I
Q
N
L
K
L
F
---
R
-
H
-
P
-------
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
----
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
-
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
-
L
D
A
-
H
-
M
N
---
A
K
---
I
A
D
F
G
L
S
---
N
-
M
--
M
--
S
----
D
G
-
E
-
F
L
--
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
------
S
------
G
---
R
L
---
Y
-
A
G
P
-
E
-
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
---
D
---
D
----
H
V
P
-------
T
----------
L
F
K
K
I
C
D
G
I
--
F
Y
T
P
Q
Y
---
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
----
I
R
E
H
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
50.89
39%
-18
- C3 -
-
2PZY
1
MAPK2_HUMAN
B:
[28-291]
-------------------------------
Q
V
---
L
G
L
G
I
N
G
K
V
L
-
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
----------
Q
-----
D
---
C
P
K-----
A
R
--------
R
E
----
V
---
E
-----
L
H
-----------
W
R
A
S
---
Q
-
C
-
P
-------
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
GRKC
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
-
G
DQ--
A
-
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
-
R
-
P
N
---
A
I
-
L
K
L
T
D
F
G
F
A
---
K
E
T
------------------------
T
P
Y
Y
V
A
P
E
V
L
------
G
------
P
---
E
K
---
Y
-
D
-
K
-
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
---
S
------------------
G
----------
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
-
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
----
F
M
N
H
P
W
I
---
M
Q
S
T
K
--
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
525
Blastp_CBE
50.84
39%
-18
- C3 -
-
4QFR
2
?
A:
[18-401]
--------------------------
Y
-
I
L
G
D
T
---
L
G
V
G
T
F
G
K
V
K
-
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
----------
N
-----
R
---
Q
-------
K
I
--------
R
S
LDVV
G
---
K
-----
I
R
---
R
---
E
I
Q
N
L
K
L
F
---
R
-
H
-
P
-------
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
----
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
-
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
-
L
D
A
-
H
-
M
N
---
A
K
---
I
A
D
F
G
L
S
---
N
-
M
--
M
--
S
----
D
G
-
E
-
F
L
--
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
------
S
------
G
---
R
L
---
Y
-
A
G
P
-
E
-
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
---
D
---
D
----
H
V
P
-------
T
----------
L
F
K
K
I
C
D
G
I
--
F
Y
T
P
Q
Y
---
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
----
I
R
E
H
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
50.85
35%
29
- C3 -
-
2UZT
1
KAPCA_BOVIN
A:
[5-267]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
----
R
--
V
----
K
G
-
R
-
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
450
Blastp_CBE
50.84
35%
30
- C3 -
-
2UZV
1
KAPCA_BOVIN
A:
[5-267]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
----
R
--
V
----
K
G
-
R
-
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
524
Blastp_CBE
50.80
39%
-22
- C3 -
-
4QFS
2
A:
[18-401]
--------------------------
Y
-
I
L
G
D
T
---
L
G
V
G
T
F
G
K
V
K
-
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
----------
N
-----
R
---
Q
-------
K
I
--------
R
S
LDVV
G
---
K
-----
I
R
---
R
---
E
I
Q
N
L
K
L
F
---
R
-
H
-
P
-------
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
----
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
-
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
-
L
D
A
-
H
-
M
N
---
A
K
---
I
A
D
F
G
L
S
---
N
-
M
--
M
--
S
----
D
G
-
E
-
F
L
--
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
------
S
------
G
---
R
L
---
Y
-
A
G
P
-
E
-
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
---
D
---
D
----
H
V
P
-------
T
----------
L
F
K
K
I
C
D
G
I
--
F
Y
T
P
Q
Y
---
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
----
I
R
E
H
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
518
Blastp_CBE
50.72
39%
-17
- C3 -
-
6E4W
2
?
A:
[18-401]
--------------------------
Y
-
I
L
G
D
T
---
L
G
V
G
T
F
G
K
V
K
-
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
----------
N
-----
R
---
Q
-------
K
I
--------
R
S
LDVV
G
---
K
-----
I
R
---
R
---
E
I
Q
N
L
K
L
F
---
R
-
H
-
P
-------
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
----
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
-
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
-
L
D
A
-
H
-
M
N
---
A
K
---
I
A
D
F
G
L
S
---
N
-
M
--
M
--
S
----
D
G
-
E
-
F
L
--
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
------
S
------
G
---
R
L
---
Y
-
A
G
P
-
E
-
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
---
D
---
D
----
H
V
P
-------
T
----------
L
F
K
K
I
C
D
G
I
--
F
Y
T
P
Q
Y
---
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
----
I
R
E
H
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
49.72
34%
29
- C3 -
-
3NX8
3
KAPCA_HUMAN
A:
[20-298]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
S
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
NGVN
D
I
N
H
K
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
502
Blastp_CBE
49.52
34%
27
- C3 -
-
3OVV
2
KAPCA_HUMAN
A:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
S
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
49.47
34%
29
- C3 -
-
3L9L
1
KAPCA_HUMAN
A:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
S
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
49.36
34%
26
- C3 -
-
3OWP
1
KAPCA_HUMAN
A:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
S
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
49.30
35%
25
- C3 -
-
2F7Z
1
KAPCA_BOVIN
E:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
-----
G
-
R
-
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
49.28
34%
25
- C3 -
-
3POO
2
KAPCA_HUMAN
A:
[20-286]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
S
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
497
Blastp_CBE
48.88
34%
29
- C3 -
-
4UJ1
2
KAPCA_HUMAN
A:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
S
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
489
Blastp_CBE
48.87
34%
30
- C3 -
-
5UZK
1
KAPCA_HUMAN
A:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
S
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
268
Blastp_CBE
48.65
39%
10
- C3 -
-
3R30
1
MAPK2_HUMAN
A:
[23-286]
-------------------------------
Q
V
---
L
G
L
G
I
-
G
K
V
L
-
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
----------
Q
-----
D
---
C
P
K-----
A
R
--------
R
E
----
V
---
E
-----
L
H
-----------
W
R
A
S
---
Q
-
C
-
P
-------
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
GRKC
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
----------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
-
R
-
P
N
---
A
I
-
L
K
L
T
D
F
G
F
A
---
K
E
T
--
T
--------------------------------------------
P
---
E
K
---
Y
-
D
-
K
-
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
---
S
------------------
G
----------
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
-
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
----
F
M
N
H
P
W
I
---
M
Q
S
T
K
--
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
48.45
34%
29
- C3 -
-
3L9L
1
KAPCA_HUMAN
B:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
S
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
48.44
34%
25
- C3 -
-
3ZO4
4
KAPCA_BOVIN
A:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
482
Blastp_CBE
48.24
34%
26
- C3 -
-
4UJB
3
KAPCA_HUMAN
A:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
S
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
499
Blastp_CBE
48.23
34%
29
- C3 -
-
3P0M
1
KAPCA_HUMAN
A:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
S
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
48.22
34%
27
- C3 -
-
5BX7
4
KAPCA_HUMAN
A:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
S
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
192
Blastp_CBE
48.21
40%
-14
- C3 -
-
3R1N
1
MAPK3_HUMAN
A:
[16-273]
-------------------------------
Q
V
---
L
G
L
G
V
N
G
K
V
L
-
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
----------
Y
-----
D
---
S
P
------
K
A
--------
R
-----------------------------
Q
E
V
---
D
-
H
-
H
WQASGGP
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
GKRC
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
R
-
G
----
A
-
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
-
E
-
K
D
---
A
V
-
L
K
L
T
D
F
G
F
A
---
K
-
E
--
T
--
T
-----------------------------------------
P
---
E
K
---
Y
-
D
-
K
-
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
-------------------------------------------
Y
G
F
P
N
P
E
W
S
-
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
I
T
Q
----
F
M
N
H
P
W
I
---
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
535
Blastp_CBE
48.20
34%
30
- C3 -
-
2C1B
1
KAPCA_BOVIN
A:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
559
Blastp_CBE
48.15
34%
24
- C3 -
-
1Q8U
3
KAPCA_BOVIN
A:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
48.08
34%
28
- C3 -
-
3OOG
1
KAPCA_HUMAN
A:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
S
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
560
Blastp_CBE
48.03
34%
29
- C3 -
-
1Q8T
1
KAPCA_BOVIN
A:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
494
Blastp_CBE
47.99
34%
29
- C3 -
-
4UJA
2
KAPCA_HUMAN
A:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
S
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
500
Blastp_CBE
47.98
34%
32
- C3 -
-
3OXT
1
KAPCA_HUMAN
A:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
S
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
496
Blastp_CBE
47.93
34%
26
- C3 -
-
4UJ2
2
KAPCA_HUMAN
A:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
S
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
539
Blastp_CBE
47.92
34%
27
- C3 -
-
1XH8
1
KAPCA_BOVIN
A:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
47.82
34%
28
- C3 -
-
3VQH
2
KAPCA_HUMAN
A:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
S
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
541
Blastp_CBE
47.83
34%
26
- C3 -
-
1XH5
3
KAPCA_BOVIN
A:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
47.82
34%
27
- C3 -
-
5BX6
4
KAPCA_HUMAN
A:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
S
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
534
Blastp_CBE
47.73
34%
28
- C3 -
-
2VO7
2
KAPCA_BOVIN
A:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
531
Blastp_CBE
47.71
34%
27
- C3 -
-
4IE9
2
KAPCA_BOVIN
A:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
47.67
34%
29
- C3 -
-
2GU8
1
KAPCA_HUMAN
A:
[6-268]
L
A
K
A
K
E
D
F
L
K
K
W
E
TP
S
--
Q
N
T
A
Q
L
D
Q
F
-
D
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
E
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
529
Blastp_CBE
47.64
34%
28
- C3 -
-
6E9L
1
KAPCA_BOVIN
A:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
537
Blastp_CBE
47.63
34%
26
- C3 -
-
4IJ9
1
KAPCA_BOVIN
A:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
564
Blastp_CBE
47.62
34%
26
- C3 -
-
3DNE
1
KAPCA_BOVIN
A:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
540
Blastp_CBE
47.58
34%
28
- C3 -
-
1XH6
1
KAPCA_BOVIN
A:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
530
Blastp_CBE
47.51
34%
28
- C3 -
-
6E99
1
KAPCA_BOVIN
A:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
47.46
34%
30
- C3 -
-
1FMO
1
KAPCA_MOUSE
E:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
TP
S
--
Q
N
T
A
Q
L
D
Q
F
-
D
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
562
Blastp_CBE
47.40
34%
30
- C3 -
-
4YXS
1
KAPCA_BOVIN
A:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
513
Blastp_CBE
47.36
34%
27
- C3 -
-
1YDT
1
KAPCA_BOVIN
E:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
536
Blastp_CBE
47.35
34%
28
- C3 -
-
2C1A
1
KAPCA_BOVIN
A:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
47.33
34%
33
- C3 -
-
3AGL
1
KAPCA_HUMAN
A:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
S
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
47.29
34%
29
- C3 -
-
1YDS
1
KAPCA_BOVIN
E:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
470
Blastp_CBE
47.28
34%
33
- C3 -
-
6C0U
4
KAPCA_HUMAN
A:
[23-285]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
S
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
47.26
34%
29
- C3 -
-
3IDB
1
KAPCA_MOUSE
A:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
TP
S
--
Q
N
T
A
Q
L
D
Q
F
-
D
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
47.22
34%
30
- C3 -
-
5VIB
1
KAPCA_BOVIN
A:
[20-306]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
47.19
34%
30
- C3 -
-
3FJQ
1
KAPCA_MOUSE
E:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
TP
S
--
Q
N
T
A
Q
L
D
Q
F
-
D
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
269
Blastp_CBE
47.17
39%
-1
- C3 -
-
3R2Y
1
MAPK2_HUMAN
A:
[23-286]
-------------------------------
Q
V
---
L
G
L
G
I
N
G
K
V
L
-
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
----------
Q
-----
D
---
C
P
K-----
A
R
--------
R
E
----
V
---
E
-----
L
H
-----------
W
R
A
S
---
Q
-
C
-
P
-------
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
GRKC
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
----------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
-
R
-
P
N
---
A
I
-
L
K
L
T
D
F
G
F
A
---
K
E
T
--
T
-------------------------------------------------------
D
-
K
-
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
---------------------------------
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
-
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
----
F
M
N
H
P
W
I
---
M
Q
S
T
K
--
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
47.14
34%
27
- C3 -
-
1YDR
1
KAPCA_BOVIN
E:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
46.99
34%
26
- C3 -
-
6MM7
9
KAPCA_MOUSE
D:
[8-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
TP
S
--
Q
N
T
A
Q
L
D
Q
F
-
D
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
558
Blastp_CBE
46.97
34%
26
- C3 -
-
1STC
1
KAPCA_BOVIN
E:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
456
Blastp_CBE
46.95
34%
28
- C3 -
-
2QUR
1
KAPCA_MOUSE
A:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
TP
S
--
Q
N
T
A
Q
L
D
Q
F
-
D
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
565
Blastp_CBE
46.86
34%
29
- C3 -
-
3DND
1
KAPCA_BOVIN
A:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
46.85
35%
32
- C3 -
-
1CDK
2
KAPCA_PIG
B:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
F
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
563
Blastp_CBE
46.84
34%
29
- C3 -
-
4YXR
1
KAPCA_BOVIN
A:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
46.65
34%
33
- C3 -
-
3MVJ
1
KAPCA_HUMAN
E:
[40-302]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
S
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
488
Blastp_CBE
46.58
34%
32
- C3 -
-
3MVJ
1
KAPCA_HUMAN
A:
[40-302]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
S
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
46.58
34%
32
- C3 -
-
1REJ
1
KAPCA_MOUSE
A:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
TP
S
--
Q
N
T
A
Q
L
D
Q
F
-
D
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
46.57
34%
26
- C3 -
-
6MM8
5
KAPCA_MOUSE
C:
[8-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
TP
S
--
Q
N
T
A
Q
L
D
Q
F
-
D
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
46.55
40%
-3
- C3 -
-
3SHE
1
MAPK3_HUMAN
A:
[16-273]
-------------------------------
Q
V
---
L
G
L
G
V
N
G
K
V
L
-
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
----------
Y
-----
D
---
S
P
------
K
A
--------
R
-----------------------------
Q
E
V
---
D
-
H
-
H
WQASGGP
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
GKRC
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
-------
A
-
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
-
E
-
K
D
---
A
V
-
L
K
L
T
D
F
G
F
A
---
K
-
E
--
T
------------------------------------------------
E
K
---
Y
-
D
-
K
-
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
-------------------------------------------
Y
G
F
P
N
P
E
W
S
-
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
I
T
Q
----
F
M
N
H
P
W
I
---
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
461
Blastp_CBE
46.50
34%
29
- C3 -
-
3IDC
1
KAPCA_MOUSE
A:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
TP
S
--
Q
N
T
A
Q
L
D
Q
F
-
D
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
46.45
34%
25
- C3 -
-
1REK
2
KAPCA_MOUSE
A:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
TP
S
--
Q
N
T
A
Q
L
D
Q
F
-
D
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
473
Blastp_CBE
46.38
34%
29
- C3 -
-
2ERZ
1
KAPCA_MOUSE
E:
[20-282]
L
A
K
A
K
E
D
F
L
K
K
W
E
TP
S
--
Q
N
T
A
Q
L
D
Q
F
-
D
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
46.26
34%
31
- C3 -
-
1ATP
1
KAPCA_MOUSE
E:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
TP
S
--
Q
N
T
A
Q
L
D
Q
F
-
D
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
46.23
34%
31
- C3 -
-
3OW3
1
KAPCA_MOUSE
A:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
TP
S
--
Q
N
T
A
Q
L
D
Q
F
-
D
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
508
Blastp_CBE
46.22
34%
33
- C3 -
-
4NTT
1
KAPCA_MOUSE
A:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
TP
S
--
Q
N
T
A
Q
L
D
Q
F
-
D
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
561
Blastp_CBE
46.14
34%
35
- C3 -
-
4WB6
1
KAPCA_HUMAN
B:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
S
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
R
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
46.11
34%
29
- C3 -
-
6MM6
1
KAPCA_MOUSE
E:
[8-283]
L
A
K
A
K
E
D
F
L
K
K
W
E
TP
S
--
Q
N
T
A
Q
L
D
Q
F
-
D
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
46.06
34%
28
- C3 -
-
4NTT
1
KAPCA_MOUSE
B:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
TP
S
--
Q
N
T
A
Q
L
D
Q
F
-
D
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
46.05
35%
28
- C3 -
-
1CDK
2
KAPCA_PIG
A:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
--
N
PA
Q
N
T
A
H
L
D
Q
F
-
E
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
T
G
N
H
F
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
46.01
39%
-5
- C3 -
-
2P3G
1
MAPK2_HUMAN
X:
[24-287]
-------------------------------
Q
V
---
L
G
L
G
I
N
G
K
V
L
-
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
----------
Q
-----
D
---
C
P
K-----
A
R
--------
R
E
----
V
---
E
-----
L
H
-----------
W
R
A
S
---
Q
-
C
-
P
-------
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
GRKC
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
-
G
DQ--
A
-
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
-
R
-
P
N
---
A
I
-
L
K
L
T
D
F
G
F
A
---
K
E
T
--
T
--
S
----------------------------------------------
K
---
Y
-
D
-
K
-
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
---
S
------------------------------------
G
Q
Y
E
F
P
N
P
E
W
S
-
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
----
F
M
N
H
P
W
I
---
M
Q
S
T
K
--
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
45.94
34%
31
- C3 -
-
4HPT
1
KAPCA_MOUSE
E:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
TP
S
--
Q
N
T
A
Q
L
D
Q
F
-
D
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
45.69
34%
30
- C3 -
-
1BKX
1
KAPCA_MOUSE
A:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
TP
S
--
Q
N
T
A
Q
L
D
Q
F
-
D
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
512
Blastp_CBE
45.63
34%
33
- C3 -
-
1JBP
2
KAPCA_MOUSE
E:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
TP
S
--
Q
N
T
A
Q
L
D
Q
F
-
D
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
E
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
45.55
43%
-5
- C3 -
-
2J90
2
DAPK3_HUMAN
A:
[32-290]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
R
-
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
LSSRR-
G
V
--------
S
R
----
E
---
E
-----
I
E
---
R
---
E
V
N
I
L
R
E
I
---
R
-
H
-
P
-------
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
-
E
----
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
-
N
V
P
N
---
P
R
-
I
K
L
I
D
F
G
I
A
H--
K
-
I
--
E
--
A
------------------
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
----
T
K
Q
-------
E
----------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
I
A
Q
-----
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
45.37
39%
-6
- C3 -
-
3FYJ
1
MAPK2_HUMAN
X:
[24-287]
-------------------------------
Q
V
---
L
G
L
G
I
N
G
K
V
L
-
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
----------
Q
-----
D
---
C
P
K-----
A
R
--------
R
E
----
V
---
E
-----
L
H
-----------
W
R
A
S
---
Q
-
C
-
P
-------
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
GRKC
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
-
G
DQ--
A
-
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
-
R
-
P
N
---
A
I
-
L
K
L
T
D
F
G
F
A
---
K
E
T
--
T
--
S
----------------------------------------------
K
---
Y
-
D
-
K
-
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
---
S
------------------------------------
G
Q
Y
E
F
P
N
P
E
W
S
-
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
----
F
M
N
H
P
W
I
---
M
Q
S
T
K
--
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
44.98
39%
-1
- C3 -
-
3FYK
1
MAPK2_HUMAN
X:
[24-287]
-------------------------------
Q
V
---
L
G
L
G
I
N
G
K
V
L
-
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
----------
Q
-----
D
---
C
P
K-----
A
R
--------
R
E
----
V
---
E
-----
L
H
-----------
W
R
A
S
---
Q
-
C
-
P
-------
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
GRKC
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
-
G
DQ--
A
-
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
-
R
-
P
N
---
A
I
-
L
K
L
T
D
F
G
F
A
---
K
E
T
--
T
--
S
----------------------------------------------
K
---
Y
-
D
-
K
-
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
---
S
------------------------------------
G
Q
Y
E
F
P
N
P
E
W
S
-
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
----
F
M
N
H
P
W
I
---
M
Q
S
T
K
--
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
44.69
40%
18
- C3 -
-
3FHR
1
MAPK3_HUMAN
A:
[35-292]
-------------------------------
Q
V
---
L
G
L
G
V
N
G
K
V
L
-
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
----------
Y
-----
D
---
S
P
------
K
A
--------
R
-----------------------------
Q
E
V
---
D
-
H
-
H
WQASGGP
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
GKRC
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
R
--DQ--
A
-
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
-
E
-
K
D
---
A
V
-
L
K
L
T
D
F
G
F
A
---
K
-
E
--
T
------------------------------------------------
E
K
---
Y
-
D
-
K
-
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
--------------------------------------------
G
F
P
N
P
E
W
S
-
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
I
T
Q
----
F
M
N
H
P
W
I
---
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
516
Blastp_CBE
44.34
34%
32
- C3 -
-
3O7L
2
KAPCA_MOUSE
B:
[19-285]
L
A
K
A
K
E
D
F
L
K
K
W
E
TP
S
--
Q
N
T
A
Q
L
D
Q
F
-
D
R
I
K
T
---
L
G
T
---
G
R
V
M
-
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
I
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
I
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
43.91
34%
38
- C3 -
-
4DIN
1
KAPCA_MOUSE
A:
[19-281]
L
A
K
A
K
E
D
F
L
K
K
W
E
TP
S
--
Q
N
T
A
Q
L
D
Q
F
-
D
R
I
K
T
---
L
G
T
G
S
F
G
R
V
M
-
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
----------
D
-----
K
---
Q
K
------
V
V
--------
K
L
----
K
---
Q
-----
I
E
HTL
N
---
E
K
R
I
L
Q
A
V
---
N
-
F
-
P
-------
F
L
V
K
L
E
F
S
F
K
D
N
S
N
----
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
----
D
-
Q
Q
---
G
Y
-
I
Q
V
T
D
F
G
F
A
---
K
-
R
--
V
--
K
----
G
----
R
T
--
W
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
---
K
G
---
Y
-
N
-
K
-
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
---
D
----
Q
P
I
-------
Q
----------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
-
D
L
----
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
197
Blastp_CBE
43.12
40%
30
- C3 -
-
3FXW
1
MAPK3_HUMAN
A:
[35-292]
-------------------------------
Q
V
---
L
G
L
G
V
-
G
K
V
L
-
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
----------
Y
-----
D
---
S
P
------
K
A
--------
R
-----------------------------
Q
E
V
---
D
-
H
-
H
WQASGGP
H
I
V
C
I
L
D
V
Y
E
N
M
H
H
GKRC
L
L
I
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
R
--DQ--
A
-
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
-
E
-
K
D
---
A
V
-
L
K
L
T
D
F
G
F
A
---
K
-
E
---------------------------------------------------
E
K
---
Y
-
D
-
K
-
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
--------------------------------------------
G
F
P
N
P
E
W
S
-
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
I
T
Q
----
F
M
N
H
P
W
I
---
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
42.85
43%
10
- C3 -
-
2J90
3
DAPK3_HUMAN
B:
[32-290]
-------------------------------
E
E
---
L
G
S
G
Q
F
A
I
V
R
-
K
C
R
Q
----
K
E
Y
A
A
K
F
I
----------
K
-----
K
---
R
R
LSSRR-
G
V
--------
S
R
----
E
---
E
-----
I
E
---
R
---
E
V
N
I
L
R
E
I
---
R
-
H
-
P
-------
N
I
I
T
L
H
D
I
F
E
N
K
T
D
----
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
-
E
------
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
-
N
V
P
N
---
P
R
-
I
K
L
I
D
F
G
I
A
H--
K
-
I
--
E
--
A
----
G
N
-
E
-
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
---
E
P
---
L
-
G
-
L
-
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---
G
---
E
----
T
K
Q
-------
E
----------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
-
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
I
A
Q
-----
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
33.78
36%
19
- C3 -
-
2X4F
4
MYLK4_HUMAN
A:
[65-358]
-------------------------------
E
I
---
L
G
G
G
R
F
G
Q
V
H
-
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
----------
K
-----
T
---
R
G
------
M
K
--------
D
K
----
E
---
E
-----
V
K
---
N
---
E
I
S
V
M
N
Q
L
---
D
-
H
-
A
-------
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
----
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
-
S
----
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
--
R
-
D
A
---
K
Q
-
I
K
I
I
D
F
G
L
A
---
R
-
R
--
Y
--
K
P---
R
E
-
K
-
L
K
--
V
N
-
F
G
T
P
E
F
L
A
P
E
V
V
------
N
------
Y
---
D
F
---
V
-
S
-
F
-
P
-
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
---
G
---
D
----
N
D
A
-------
E
----------
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
-
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
----
A
L
K
H
P
W
L
---
S
D
H
K
-------
L
-
H
-
S
R
L
S
A
Q
-
K
K
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------