@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KCC2A_HUMAN: (2020-09-11 )
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
Atome Classification :
(127 SA)
.........10.......-.-20........30........40.......-.--50-----....-.---....60..-....-..-70........80--....-----..--..90........100..--.----.-...110.......120.......130.......140.......150.......160--........170.......180...-----.------.---..190..-......200.......210.------..-..-----..-220...-....230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.-......400.......410.......420.......430.......440..-.....450.......460.......470......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
A
T
I
T
C
T
R
F
T
E
E
Y
Q
L
F
E
E
-L-
G
K
G
A
F
S
V
V
R
R
C
V
K
V
LAG
Q
E
Y
A
A
K
I
I
NTKK-L--S------
A
R
D
H
-
Q
---
K
L
E
R
E
A
R
I
-
C
R
L
L-KH-P
N
I
V
R
LHDSISE--EG
H
H
-----
Y
L
--
I
F
D
LVT
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-YSEA
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
QM
G
V
V
HRDLKPENL
L
L
A
S
KLKG
A
A
V
K
L
A
D
F
G
L
A
-
I
--
E
V
EGEQ
Q
A
W
F
GFAGTPGYL
S
P
E
V
L-----R------K---DPY-GK
P
-
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
VGYPPF------WD-
E
D
-----
Q
H
-
R
L
Y
Q
Q
I
-
K
AGAYDFPSPEWDTVTP
E
A
K
D
L
I
N
K
M
LTINPSKR
I
T
A
A
E
A
LKHP
W
I
S
H
R
S
T
V
A
S
C
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
ATRNFSGGKSGGNKKSDGVKESSESTNTTIEDED
T
K
V
R
K
Q
E
I
I
K
V
T
E
Q
L
I
E
A
I
SNG
D
F
E
S
Y
T
KMCDPGMTAF
E
P
E
A
L
G
N
L
V
E
G
L
D
-
F
H
R
F
Y
F
E
N
L
WSRNSK
P
V
H
T
T
I
LN
P
H
I
H
L
MGDE
S
A
C
I
A
Y
I
R
I
T
Q
Y
L
DAGGIP-RTAQSEE
T
R
V
W
HRRDG
K
W
Q
I
V
H
F
HRSGAPSVLPH
1
PsiBlast_PDB
94.54
100%
-108
- C3 -
-
5U6Y
-
KCC2A_RAT
A:
[2-461]
------------
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
K
I
I
N
T
K
K
-
L
--
S
------
A
R
D
H
-
Q
---
K
L
E
R
E
A
R
I
-
C
R
L
L
-
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
H
H
-----
Y
L
--
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
L
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
--
E
V
E
G
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
-----
Q
H
-
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
S
H
R
S
T
V
A
S
C
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
A
T
R
N
F
S
G
G
K
S
G
G
N
K
K
S
D
G
V
K
E
S
S
E
S
T
N
T
T
I
E
D
E
D
T
K
V
R
K
Q
E
I
I
K
V
T
E
Q
L
I
E
A
I
S
N
G
D
F
E
S
Y
T
K
M
C
D
P
G
M
T
A
F
E
P
E
A
L
G
N
L
V
E
G
L
D
-
F
H
R
F
Y
F
E
N
L
W
S
--
S
K
P
V
H
T
T
I
L
N
P
H
I
H
L
M
G
D
E
S
A
C
I
A
Y
I
R
I
T
Q
Y
L
D
A
G
G
I
P
-
R
T
A
Q
S
E
E
T
R
V
W
H
R
R
D
G
K
W
Q
I
V
H
F
H
R
S
G
A
------
603
HHSearch
92.28
96%
-113
- C3 -
-
5U6Y
-
KCC2A_RAT
J:
[2-461]
------------
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
K
I
I
N
T
K
K
-
L
--
S
------
A
R
D
H
-
Q
---
K
L
E
R
E
A
R
I
-
C
R
L
L
-
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
H
H
-----
Y
L
--
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
L
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
--
E
V
E
G
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
-----
Q
H
-
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
S
H
R
S
T
V
A
S
C
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
A
T
R
N
F
S
G
G
K
S
G
G
N
K
K
S
D
G
V
K
E
S
S
E
S
T
N
T
T
I
E
D
E
D
T
K
V
R
K
Q
E
I
I
K
V
T
E
Q
L
I
E
A
I
S
N
G
D
F
E
S
Y
T
K
M
C
D
P
G
M
T
A
F
E
P
E
A
L
G
N
L
V
E
G
L
D
-
F
H
R
F
Y
F
E
N
L
W
S
--
S
K
P
V
H
T
T
I
L
N
P
H
I
H
L
M
G
D
-
E
S
A
C
I
A
Y
I
R
I
T
Q
Y
L
D
A
G
G
I
P
R
T
A
Q
S
E
E
T
R
V
W
H
R
R
D
G
K
W
Q
I
V
H
F
H
R
S
G
A
------
605
HHSearch
86.55
97%
-92
- C3 -
-
3SOA
1
KCC2A_HUMAN
A:
[7-443]
------
T
R
F
T
E
E
Y
Q
L
F
E
E
-
L
-
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
T
K
K
-
L
--
S
------
A
R
D
H
-
Q
---
K
L
E
R
E
A
R
I
-
C
R
L
L
-
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
H
H
-----
Y
L
--
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
L
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
--
E
V
E
G
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
-----
Q
H
-
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
S
H
R
S
T
V
A
S
C
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
V
M
L
A
T
R
N
------------------------------
F
S
V
R
K
Q
E
I
I
K
V
T
E
Q
L
I
E
A
I
S
N
G
D
F
E
S
Y
T
K
M
C
D
P
G
M
T
A
F
E
P
E
A
L
G
N
L
V
E
G
L
D
F
H
R
F
Y
-
F
E
N
L
W
S
R
N
S
K
P
V
H
T
T
I
L
N
P
H
I
H
L
M
G
D
E
S
A
C
I
A
Y
I
R
I
T
Q
Y
L
D
-
A
G
G
I
P
R
T
A
Q
S
E
E
T
R
V
W
H
R
R
D
G
K
W
Q
I
V
H
F
H
R
S
G
A
P
-----
2
PsiBlast_PDB
86.03
93%
-96
- C3 -
-
3SOA
1
KCC2A_HUMAN
A:
[7-444]
------
T
R
F
T
E
E
Y
Q
L
F
E
E
-
L
-
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
T
K
K
-
L
--
S
------
A
R
D
H
-
Q
---
K
L
E
R
E
A
R
I
-
C
R
L
L
-
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
H
H
-----
Y
L
--
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
L
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
--
E
V
E
G
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
-----
Q
H
-
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
S
H
R
S
T
V
A
S
C
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
V
M
L
A
T
R
N
F
S
------------------------------
V
R
K
Q
E
I
I
K
V
T
E
Q
L
I
E
A
I
S
N
G
D
F
E
S
Y
T
K
M
C
D
P
G
M
T
A
F
E
P
E
A
L
G
N
L
V
E
G
L
D
-
F
H
R
F
Y
F
E
N
L
W
S
R
N
S
K
P
V
H
T
T
I
L
N
P
H
I
H
L
M
G
D
E
S
A
C
I
A
Y
I
R
I
T
Q
Y
L
D
A
G
G
I
P
-
R
T
A
Q
S
E
E
T
R
V
W
H
R
R
D
G
K
W
Q
I
V
H
F
H
R
S
G
A
P
S
----
21
Blastp_CBE
70.89
99%
-122
- C3 -
-
2VZ6
3
KCC2A_HUMAN
B:
[20-311]
--------
F
Q
S
M
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
K
I
I
N
T
K
K
-
L
--
S
------
A
R
D
H
-
Q
---
K
L
E
R
E
A
R
I
-
C
R
L
L
-
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
H
H
-----
Y
L
--
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
L
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
--
E
V
E
G
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
-----
Q
H
-
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
S
H
R
S
T
V
A
S
C
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
608
HHSearch
70.80
93%
-119
- C3 -
-
2VN9
2
KCC2D_HUMAN
A:
[2-300]
--------
M
T
D
E
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
-
L
--
S
------
A
R
D
H
-
Q
---
K
L
E
R
E
A
R
I
-
C
R
L
L
-
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
--
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
--
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
-----
Q
H
-
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
70.59
98%
-125
- C3 -
-
2VZ6
2
KCC2A_HUMAN
A:
[20-310]
--------
F
Q
S
M
Y
Q
L
F
E
E
-
L
-
G
K
--
F
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
K
I
I
N
T
K
K
-
L
--
S
------
A
R
D
H
-
Q
---
K
L
E
R
E
A
R
I
-
C
R
L
L
-
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
H
H
-----
Y
L
--
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
L
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
--
E
V
E
G
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
-----
Q
H
-
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
S
H
R
S
T
V
A
S
C
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
606
HHSearch
70.36
92%
-131
- C3 -
-
2WEL
7
KCC2D_HUMAN
A:
[2-308]
--------
M
T
D
E
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
-
L
--
S
------
A
R
D
H
-
Q
---
K
L
E
R
E
A
R
I
-
C
R
L
L
-
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
--
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
--
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
-----
Q
H
-
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
----
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
A
T
R
N
F
S
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
70.32
92%
-119
- C3 -
-
2VN9
2
KCC2D_HUMAN
A:
[2-301]
--------
M
T
D
E
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
-
L
--
S
------
A
R
D
H
-
Q
---
K
L
E
R
E
A
R
I
-
C
R
L
L
-
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
--
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
--
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
-----
Q
H
-
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
70.08
90%
-131
- C3 -
-
2WEL
7
KCC2D_HUMAN
A:
[2-308]
--------
M
T
D
E
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
-
L
--
S
------
A
R
D
H
-
Q
---
K
L
E
R
E
A
R
I
-
C
R
L
L
-
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
--
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
--
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
-----
Q
H
-
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
----
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
A
T
R
N
F
S
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
69.48
89%
-118
- C3 -
-
2V7O
3
KCC2G_HUMAN
A:
[25-321]
----
T
C
T
R
F
T
D
D
Y
Q
L
F
E
E
-
L
-
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
T
K
K
-
L
--
S
------
A
R
D
H
-
Q
---
K
L
E
R
E
A
R
I
-
C
R
L
L
-
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
--
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
--
E
V
Q
G
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
-----
Q
H
-
K
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
R
K
F
N
A
R
R
K
L
K
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
69.40
93%
-119
- C3 -
-
2VN9
1
KCC2D_HUMAN
B:
[2-301]
--------
M
T
D
E
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
-
L
--
S
------
A
R
D
H
-
Q
---
K
L
E
R
E
A
R
I
-
C
R
L
L
-
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
--
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
--
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
-----
Q
H
-
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
68.92
92%
-119
- C3 -
-
6AYW
2
KCC2D_HUMAN
A:
[9-301]
------
T
R
F
T
D
E
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
-
L
--
S
------
A
R
D
H
-
Q
---
K
L
E
R
E
A
R
I
-
C
R
L
L
-
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
--
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
--
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
-----
Q
H
-
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
68.62
90%
-125
- C3 -
-
3BHH
1
KCC2B_HUMAN
A:
[2-293]
--------
M
T
D
E
Y
Q
L
Y
E
D
-
I
-
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
K
-
L
--
S
------
A
R
D
H
-
Q
---
K
L
E
R
E
A
R
I
-
C
R
L
L
-
K
H
-
S
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
--
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
--
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
E
A
Y
-
G
K
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
-----
Q
H
-
K
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
K
K
F
N
A
R
R
K
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
68.56
90%
-124
- C3 -
-
3BHH
1
KCC2B_HUMAN
B:
[2-293]
--------
M
T
D
E
Y
Q
L
Y
E
D
-
I
-
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
K
-
L
--
S
------
A
R
D
H
-
Q
---
K
L
E
R
E
A
R
I
-
C
R
L
L
-
K
H
-
S
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
--
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
--
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
E
A
Y
-
G
K
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
-----
Q
H
-
K
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
K
K
F
N
A
R
R
K
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
68.28
92%
-116
- C3 -
-
5VLO
2
KCC2D_HUMAN
A:
[9-301]
------
T
R
F
T
D
E
Y
Q
L
F
E
E
-
L
-
G
---
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
-
L
--
S
------
A
R
D
H
-
Q
---
K
L
E
R
E
A
R
I
-
C
R
L
L
-
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
--
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
--
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
-----
Q
H
-
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
68.23
92%
-118
- C3 -
-
6AYW
2
KCC2D_HUMAN
B:
[8-300]
-----
C
T
R
F
T
D
E
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
-
L
--
S
------
A
R
D
H
-
Q
---
K
L
E
R
E
A
R
I
-
C
R
L
L
-
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
--
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
--
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
-----
Q
H
-
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
68.07
92%
-114
- C3 -
-
5VLO
2
KCC2D_HUMAN
B:
[8-300]
-----
C
T
R
F
T
D
E
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
-
L
--
S
------
A
R
D
H
-
Q
---
K
L
E
R
E
A
R
I
-
C
R
L
L
-
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
--
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
--
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
-----
Q
H
-
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
611
HHSearch
67.34
80%
-131
- C3 -
-
3KK8
-
?
A:
[2-283]
------
T
K
F
S
D
N
Y
D
V
K
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
-
L
--
S
------
A
R
D
F
-
Q
---
K
L
E
R
E
A
R
I
-
C
R
K
L
-
Q
H
-
P
N
I
V
R
L
H
D
S
I
Q
E
--
E
S
F
H
-----
Y
L
--
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
F
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
A
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
--
E
V
N
D
S
-
E
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-----
K
------
K
---
D
P
Y
-
S
K
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
-----
Q
H
-
R
L
Y
A
Q
I
-
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
T
A
D
Q
A
L
K
V
P
W
I
C
N
R
E
R
V
A
S
A
I
H
R
Q
D
T
V
D
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
67.09
77%
-118
- C3 -
-
2BDW
-
KCC2D_CAEEL
A:
[6-315]
------
T
K
F
S
D
N
Y
D
V
K
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
-
L
--
S
------
A
R
D
F
-
Q
---
K
L
E
R
E
A
R
I
-
C
R
K
L
-
Q
H
-
P
N
I
V
R
L
H
D
S
I
Q
E
--
E
S
F
H
-----
Y
L
--
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
F
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
A
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
--
E
V
-
N
D
S
E
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-----
K
------
K
---
D
P
Y
-
S
K
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
-----
Q
H
-
R
L
Y
A
Q
I
-
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
T
A
D
Q
A
L
K
V
P
W
I
C
N
R
E
R
V
A
S
A
I
H
R
Q
D
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
I
A
T
R
N
L
S
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
66.64
92%
-114
- C3 -
-
6BAB
3
KCC2D_MOUSE
C:
[14-301]
-----------
E
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
----
Q
E
Y
A
A
K
I
I
N
T
K
K
-
L
--
S
------
A
R
D
H
-
Q
---
K
L
E
R
E
A
R
I
-
C
R
L
L
-
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
--
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
--
E
V
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
D
-
E
D
-----
Q
H
-
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
610
HHSearch
53.64
47%
-40
- C3 -
-
3C0I
1
CSKP_HUMAN
A:
[21-317]
-------
L
F
E
D
V
Y
E
L
C
E
V
-
I
-
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
-
F
--
T
SSP---
G
L
S
T
-
E
---
D
L
K
R
E
A
S
I
-
C
H
M
L
-
K
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
-----
Y
M
--
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--
A
DAGF
V
-
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
N
S
A
P
V
K
L
G
G
F
G
V
A
-
I
--
Q
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
-----
K
------
R
---
E
P
Y
-
G
K
P
-
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
G
-
T
K
-----
E
--
R
L
F
E
G
I
-
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
609
HHSearch
53.58
47%
-35
- C3 -
-
3C0G
1
CSKP_HUMAN
B:
[21-326]
-------
L
F
E
D
V
Y
E
L
C
E
V
-
I
-
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
-
F
--
T
SSP---
G
L
S
T
-
E
---
D
L
K
R
E
A
S
I
-
C
H
M
L
-
K
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
-----
Y
M
--
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--
A
DAGF
V
-
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
N
S
A
P
V
K
L
G
G
F
G
V
A
-
I
--
Q
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
-----
K
------
R
---
E
P
Y
-
G
K
P
-
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
G
-
T
K
-----
E
--
R
L
F
E
G
I
-
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
L
K
G
A
V
L
A
A
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
623
HHSearch
53.15
37%
-124
- C3 -
-
3Q5I
1
?
A:
[31-310]
-----
E
G
K
I
G
E
S
Y
F
K
V
R
K
-
L
-
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K
--------------
K
F
H
-
E
---
E
I
Y
N
E
I
S
L
-
L
K
S
L
-
D
H
-
P
N
I
I
K
L
F
D
V
F
E
D
--
K
K
Y
F
-----
Y
L
--
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
R
--
H
----
K
-
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
N
K
N
S
L
L
N
I
K
I
V
D
F
G
L
S
-
S
--
F
F
S
K
D
Y
-
K
L
R
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
-----
K
------
K
----
K
Y
-
N
E
K
-
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
------
G
G
-
Q
N
-----
D
Q
-
D
I
I
K
K
V
-
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
A
E
E
A
L
N
S
R
W
I
K
K
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
52.61
34%
-144
- C3 -
-
4BFM
1
MELK_MOUSE
A:
[11-263]
------------
Y
E
L
Y
E
T
-
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
D
K
N
A
-
L
--
G
------
S
-
D
L
-
P
---
R
V
K
T
E
I
D
A
-
L
K
S
L
-
R
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
--
K
N
K
I
-----
F
M
--
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
--
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
N
H
K
---
L
K
L
I
D
F
G
L
C
-
A
--
K
-----------
C
G
S
L
A
Y
A
A
P
E
L
I
-----
Q
--------------
G
S
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
-----
V
M
-
A
L
Y
K
K
I
-
M
R
G
K
Y
E
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
R
N
L
L
N
H
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
51.89
34%
-142
- C3 -
-
4CQG
1
MELK_MOUSE
A:
[11-263]
------------
Y
E
L
Y
E
T
-
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
D
K
N
A
-
L
--
G
------
S
-
D
L
-
P
---
R
V
K
T
E
I
D
A
-
L
K
S
L
-
R
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
--
K
N
K
I
-----
F
M
--
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
--
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
N
H
K
---
L
K
L
I
D
F
G
L
C
-
A
--
K
-----------
C
G
S
L
A
Y
A
A
P
E
L
I
-----
Q
--------------
G
S
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
-----
V
M
-
A
L
Y
K
K
I
-
M
R
G
K
Y
E
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
R
N
L
L
N
H
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
51.84
34%
-149
- C3 -
-
4BL1
1
MELK_HUMAN
A:
[12-264]
------------
Y
E
L
H
E
T
-
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
-
L
------------
L
-
P
---
R
I
K
T
E
I
E
A
-
L
K
N
L
-
R
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
--
A
N
K
I
-----
F
M
--
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
--
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
---
L
K
L
I
D
F
G
L
C
-
A
--
K
-------------
S
L
A
Y
A
A
P
E
L
I
-----
Q
------
G
---
K
---
G
S
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
-----
V
M
-
A
L
Y
K
K
I
-
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
615
HHSearch
51.09
42%
-91
- C3 -
-
2W4O
1
KCC4_HUMAN
A:
[50-343]
-------
A
L
S
D
F
F
E
V
E
S
E
-
L
-
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
---------------------------
I
G
V
-
L
L
R
L
-
S
H
-
P
N
I
I
K
L
K
E
I
F
E
T
--
P
T
E
I
-----
S
L
--
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
--
G
----
Y
-
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
A
P
D
A
P
L
K
I
A
D
F
--------------------
G
T
P
G
Y
C
A
P
E
I
L
-----
R
------
G
---
C
A
Y
-
G
P
E
-
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
------
Y
D
-
E
R
-----
G
D
Q
F
M
F
R
R
I
-
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
T
G
K
A
A
--
N
F
V
H
M
D
T
A
Q
K
K
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
335
Blastp_CBE
51.01
37%
-118
- C3 -
-
5ES1
1
MARK4_HUMAN
A:
[17-269]
------------
Y
R
L
L
R
T
-
I
-
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
-
L
--
N
------
P
S
S
L
-
Q
---
K
L
F
R
E
V
R
I
-
M
K
G
L
-
N
H
-
P
N
I
V
K
L
F
E
V
I
E
T
--
E
K
T
L
-----
Y
L
--
V
M
E
Y
A
S
A
G
E
V
F
D
Y
L
V
S
H
--
G
----
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
K
N
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
E
---
A
N
I
K
I
A
D
F
G
F
S
-
N
----------------
S
P
P
Y
A
A
P
E
L
F
-----
Q
------
G
---
K
K
Y
-
D
G
P
E
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
------
D
G
-
H
N
-----
L
K
-
E
L
R
E
R
V
-
L
R
G
K
Y
R
V
P
F
----
Y
M
S
T
D
C
E
S
I
L
R
R
F
L
V
L
N
P
A
K
R
C
T
L
E
Q
I
M
K
D
K
W
I
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
50.06
34%
-114
- C3 -
-
5TWL
1
MELK_HUMAN
A:
[12-264]
------------
Y
E
L
H
E
T
-
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
-
L
--
G
------
S
-
D
L
-
P
---
R
I
K
T
E
I
E
A
-
L
K
N
L
-
R
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
--
A
N
K
I
-----
F
M
--
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
--
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
---
L
K
L
I
D
F
G
L
-----------------
C
G
S
L
A
Y
A
A
P
E
L
I
-----
Q
------
G
---
K
S
Y
L
G
S
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
D
-
D
N
-----
V
M
-
A
L
Y
K
K
I
-
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
49.74
38%
-102
- C3 -
-
5EAK
1
MARK2_HUMAN
B:
[17-269]
------------
Y
R
L
L
K
T
-
I
-
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
-
L
--
N
------
S
S
S
L
-
Q
---
K
L
F
R
E
V
R
I
-
M
K
V
L
-
N
H
-
P
N
I
V
K
L
F
E
V
I
E
T
--
E
K
T
L
-----
Y
L
--
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
--
G
----
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
N
---
I
K
I
A
D
F
G
-----------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
-----
Q
------
G
---
K
K
Y
-
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
------
D
G
-
Q
N
-----
L
K
-
E
L
R
E
R
V
-
L
R
G
K
Y
R
I
P
F
----
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
49.40
38%
-111
- C3 -
-
5KZ7
1
MARK2_HUMAN
A:
[35-287]
------------
Y
R
L
L
K
T
-
I
-
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
-
L
--
N
------
S
S
S
L
-
Q
---
K
L
F
R
E
V
R
I
-
M
K
V
L
-
N
H
-
P
N
I
V
K
L
F
E
V
I
E
T
--
E
K
T
L
-----
Y
L
--
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
--
G
----
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
N
---
I
K
I
A
D
F
--------------------
G
S
P
P
Y
A
A
P
E
L
F
-----
Q
------
G
---
K
---
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
------
D
---
N
-----
L
K
-
E
L
R
E
R
V
-
L
R
G
K
Y
R
I
P
F
----
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
49.33
37%
-67
- C3 -
-
2X4F
3
MYLK4_HUMAN
B:
[95-347]
----------------
E
I
-
L
-
G
G
G
--
G
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
-
M
----------
K
D
K
-
E
---
E
V
K
N
E
I
S
V
-
M
N
Q
L
-
D
H
-
A
N
L
I
Q
L
Y
D
A
F
E
S
--
K
N
D
I
-----
V
L
--
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
--
S
----
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
-
D
A
K
Q
I
K
I
I
D
F
G
L
A
-
R
--
R
Y
K
P
R
E
K
L
K
V
N
F
-
G
T
P
E
F
L
A
P
E
V
V
-----
N
------
Y
---
D
F
V
-
S
F
P
-
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
------
L
G
-
D
N
-----
D
A
-
E
T
L
N
N
I
-
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
291
Blastp_CBE
49.20
38%
-106
- C3 -
-
5KZ8
1
MARK2_HUMAN
A:
[35-287]
------------
Y
R
L
L
K
T
-
I
-
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
-
L
--
N
------
S
S
S
L
-
Q
---
K
L
F
R
E
V
R
I
-
M
K
V
L
-
N
H
-
P
N
I
V
K
L
F
E
V
I
E
T
--
E
K
T
L
-----
Y
L
--
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
--
G
----
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
N
---
I
K
I
A
D
F
G
------------------
C
G
S
P
P
Y
A
A
P
E
L
F
-----
Q
------
G
---
K
K
Y
-
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
------
D
G
-
Q
N
-----
L
K
-
E
L
R
E
R
V
-
L
R
G
K
Y
R
I
P
F
----
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
49.15
38%
-111
- C3 -
-
5KZ7
1
MARK2_HUMAN
B:
[35-287]
------------
Y
R
L
L
K
T
-
I
-
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
-
L
--
N
------
S
S
S
L
-
Q
---
K
L
F
R
E
V
R
I
-
M
K
V
L
-
N
H
-
P
N
I
V
K
L
F
E
V
I
E
T
--
E
K
T
L
-----
Y
L
--
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
--
G
----
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
N
---
I
K
I
A
D
F
--------------------
G
S
P
P
Y
A
A
P
E
L
F
-----
Q
------
G
---
K
---
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
------
D
---
N
-----
L
K
-
E
L
R
E
R
V
-
L
R
G
K
Y
R
I
P
F
----
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
48.77
38%
-98
- C3 -
-
5EAK
1
MARK2_HUMAN
A:
[17-269]
------------
Y
R
L
L
K
T
-
I
-
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
-
L
--
N
------
S
S
S
L
-
Q
---
K
L
F
R
E
V
R
I
-
M
K
V
L
-
N
H
-
P
N
I
V
K
L
F
E
V
I
E
T
--
E
K
T
L
-----
Y
L
--
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
--
G
----
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
N
---
I
K
I
A
D
F
G
F
S
---------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
-----
Q
------
G
---
K
K
Y
-
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
------
D
G
-
Q
N
-----
L
K
-
E
L
R
E
R
V
-
L
R
G
K
Y
R
I
P
F
----
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
48.74
38%
-104
- C3 -
-
5KZ8
1
MARK2_HUMAN
B:
[35-287]
------------
Y
R
L
L
K
T
-
I
-
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
-
L
--
N
------
S
S
S
L
-
Q
---
K
L
F
R
E
V
R
I
-
M
K
V
L
-
N
H
-
P
N
I
V
K
L
F
E
V
I
E
T
--
E
K
T
L
-----
Y
L
--
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
--
G
----
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
N
---
I
K
I
A
D
F
--------------------
G
S
P
P
Y
A
A
P
E
L
F
-----
Q
------
G
---
K
K
Y
-
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
------
D
G
-
Q
N
-----
L
K
-
E
L
R
E
R
V
-
L
R
G
K
Y
R
I
P
F
----
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
47.38
38%
-95
- C3 -
-
2CN5
1
CHK2_HUMAN
A:
[16-284]
----------
D
E
Y
I
M
S
K
T
-
L
-
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
R
---------------------
N
V
E
T
E
I
E
I
-
L
K
K
L
-
N
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
-
D
Y
-----
Y
I
--
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
----
K
I
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
47.05
38%
-103
- C3 -
-
4BDH
4
CHK2_HUMAN
A:
[16-284]
----------
D
E
Y
I
M
S
K
T
-
L
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
----------------------
N
V
E
T
E
I
E
I
-
L
K
K
L
-
N
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
-
D
Y
-----
Y
I
--
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
----
K
I
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
46.57
38%
-108
- C3 -
-
4BDD
3
CHK2_HUMAN
A:
[16-284]
----------
D
E
Y
I
M
S
K
T
-
L
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
----------------------
N
V
E
T
E
I
E
I
-
L
K
K
L
-
N
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
-
D
Y
-----
Y
I
--
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
----
K
I
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
342
Blastp_CBE
46.12
36%
-46
- C3 -
-
6QF4
2
ST17B_HUMAN
A:
[35-291]
----------------
K
E
-
L
-
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
K
R
R
-
R
--
G
------
Q
D
C
R
-
A
---
E
I
L
H
E
I
A
V
-
L
E
L
A
-
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
--
T
S
E
I
-----
I
L
--
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
E
LA
E
----
M
-
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
L
S
S
I
Y
P
L
G
D
I
K
I
V
D
F
G
M
S
-
R
--
K
I
-
G
H
A
C
----
I
M
G
T
P
E
Y
L
A
P
E
I
L
-----
N
------
Y
---
D
P
I
-
T
T
A
-
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
------
V
G
-
E
D
-----
N
Q
-
E
T
Y
L
N
I
-
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
45.95
38%
-103
- C3 -
-
2CN8
1
CHK2_HUMAN
A:
[16-284]
----------
D
E
Y
I
M
S
K
T
-
L
-
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
----------------------
N
V
E
T
E
I
E
I
-
L
K
K
L
-
N
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
-
D
Y
-----
Y
I
--
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
----
K
I
L
--
T
S
L
M
R
T
L
C
--
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H--------
V
-
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
616
HHSearch
45.08
42%
-5
- C3 -
-
2Y7J
1
PHKG2_HUMAN
A:
[91-364]
-------
E
F
Y
Q
K
Y
D
P
K
D
V
-
I
-
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
-
E
--
R
LSPEQL
E
E
V
R
-
E
---
A
T
R
R
E
T
H
I
-
L
R
Q
V
A
G
H
-
P
H
I
I
T
L
I
D
S
Y
E
S
--
S
S
F
M
-----
F
L
--
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
--
V
----
A
-
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
---
N
M
Q
I
R
L
S
D
F
G
F
S
-
C
--
H
L
E
P
G
-
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
-----
K
CSMDET
H
---
P
G
Y
-
G
K
E
-
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
------
W
H
-
R
R
-----
Q
I
-
L
M
L
R
M
I
-
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
45.06
36%
-49
- C3 -
-
3LM0
2
ST17B_HUMAN
A:
[35-291]
----------------
K
E
-
L
-
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
K
R
R
-
R
--
G
------
Q
D
C
R
-
A
---
E
I
L
H
E
I
A
V
-
L
E
L
A
-
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
--
T
S
E
I
-----
I
L
--
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
E
LA
E
----
M
-
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
L
S
S
I
Y
P
L
G
D
I
K
I
V
D
F
G
M
S
-
R
--
K
----------
I
M
G
T
P
E
Y
L
A
P
E
I
L
-----
N
------
Y
---
D
P
I
-
T
T
A
-
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
------
V
G
-
E
D
-----
N
Q
-
E
T
Y
L
N
I
-
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
44.16
36%
-40
- C3 -
-
6C9H
2
AAPK1_HUMAN
A:
[16-318]
------------
Y
I
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
-
I
--
R
------
S
L
D
V
V
G
---
K
I
R
R
E
I
Q
N
-
L
K
L
F
-
R
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
S
D
I
-----
F
M
--
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
---
K
I
A
D
F
G
L
S
----
N
M
M
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
D
-
D
H
-----
V
P
-
T
L
F
K
K
I
-
C
D
G
I
--
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
43.92
38%
-108
- C3 -
-
2XM8
1
CHK2_HUMAN
A:
[16-284]
----------
D
E
Y
I
M
S
K
T
-
L
-
G
-----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
-------------------------
N
V
E
T
E
I
E
I
-
L
K
K
L
-
N
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
-
D
Y
-----
Y
I
--
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
----
K
I
L
--
T
S
L
M
R
T
L
C
G
---
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
533
Blastp_CBE
43.85
36%
-39
- C3 -
-
4REW
1
AAPK1_HUMAN
A:
[8-389]
------------
Y
I
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
-
I
--
R
------
S
L
D
V
V
G
---
K
I
R
R
E
I
Q
N
-
L
K
L
F
-
R
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
S
D
I
-----
F
M
--
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
---
K
I
A
D
F
G
L
S
----
N
M
M
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
D
-
D
H
-----
V
P
-
T
L
F
K
K
I
-
C
D
G
I
--
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
S
I
K
D
I
R
E
H
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
350
Blastp_CBE
43.59
36%
-56
- C3 -
-
6CJH
1
MKNK2_HUMAN
A:
[9-299]
-------
R
F
E
D
V
Y
Q
L
Q
E
D
V
L
-
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
K
Q
P
-
G
--
H
------
I
R
S
R
-
V
---
F
R
E
V
E
M
-
L
-
Y
Q
C
Q
-
G
H
-
R
N
V
L
E
L
I
E
F
F
E
E
--
E
D
R
F
-----
Y
L
--
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
--
R
----
H
-
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
-------------------
G
S
A
E
Y
M
A
P
E
V
V
EAFSE
E
------
A
---
S
I
Y
-
D
K
R
-
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG-----ACPAC
Q
N
-
M
L
F
E
S
I
-
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
43.16
36%
-53
- C3 -
-
6CK6
1
MKNK2_HUMAN
A:
[9-299]
-------
R
F
E
D
V
Y
Q
L
Q
E
D
V
L
-
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
K
Q
P
-
G
--
H
------
I
R
S
R
-
V
---
F
R
E
V
E
M
-
L
-
Y
Q
C
Q
-
G
H
-
R
N
V
L
E
L
I
E
F
F
E
E
--
E
D
R
F
-----
Y
L
--
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
--
R
----
H
-
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
-------------------
G
S
A
E
Y
M
A
P
E
V
V
EAFSE
E
------
A
---
S
I
Y
-
D
K
R
-
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG-----ACPAC
Q
N
-
M
L
F
E
S
I
-
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
43.10
36%
-52
- C3 -
-
6CK3
1
MKNK2_HUMAN
A:
[9-299]
-------
R
F
E
D
V
Y
Q
L
Q
E
D
V
L
-
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
K
Q
P
-
G
--
H
------
I
R
S
R
-
V
---
F
R
E
V
E
M
-
L
-
Y
Q
C
Q
-
G
H
-
R
N
V
L
E
L
I
E
F
F
E
E
--
E
D
R
F
-----
Y
L
--
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
--
R
----
H
-
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
-------------------
G
S
A
E
Y
M
A
P
E
V
V
EAFSE
E
------
A
---
S
I
Y
-
D
K
R
-
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG-----ACPAC
Q
N
-
M
L
F
E
S
I
-
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
42.85
36%
-49
- C3 -
-
6CKI
1
MKNK2_HUMAN
A:
[9-299]
-------
R
F
E
D
V
Y
Q
L
Q
E
D
V
L
-
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
K
Q
P
-
G
--
H
------
I
R
S
R
-
V
---
F
R
E
V
E
M
-
L
-
Y
Q
C
Q
-
G
H
-
R
N
V
L
E
L
I
E
F
F
E
E
--
E
D
R
F
-----
Y
L
--
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
--
R
----
H
-
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
-------------------
G
S
A
E
Y
M
A
P
E
V
V
EAFSE
E
------
A
---
S
I
Y
-
D
K
R
-
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG-----ACPAC
Q
N
-
M
L
F
E
S
I
-
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
577
Blastp_CBE
42.81
34%
-8
- C3 -
-
5OS2
2
AURKA_HUMAN
A:
[5-265]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
------
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
580
Blastp_CBE
42.69
33%
-9
- C3 -
-
4JBQ
1
AURKA_HUMAN
A:
[9-269]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
-----------
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
42.69
34%
-7
- C3 -
-
6R49
2
AURKA_HUMAN
A:
[13-273]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
-------
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
517
Blastp_CBE
42.67
34%
-15
- C3 -
-
3P9J
1
AURKA_HUMAN
A:
[8-265]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
---------------
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
--------
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
584
Blastp_CBE
42.66
33%
-12
- C3 -
-
3K5U
1
AURKA_HUMAN
A:
[9-272]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
-----------
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
N
C
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
285
Blastp_CBE
42.54
39%
-30
- C3 -
-
4CZT
3
CIPKN_ARATH
C:
[12-268]
-----------
K
Y
E
L
G
R
T
-
L
-
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
--
K
------
N
K
M
I
-
A
---
Q
I
K
R
E
I
S
T
-
M
K
L
I
-
K
H
-
P
N
V
I
R
M
F
E
V
M
A
S
--
K
T
K
I
-----
Y
F
--
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
--
G
----
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
N
---
G
A
L
K
V
S
D
F
G
L
S
-
A
LP
Q
Q
V
R
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
-----
N
------
N
---
K
G
Y
D
G
A
K
-
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
------
E
D
-
S
N
-----
L
T
-
S
L
Y
K
K
I
F
K
A
---
E
F
T
C
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
42.24
34%
-7
- C3 -
-
3H10
1
AURKA_HUMAN
B:
[8-268]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
A
--
A
L
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
586
Blastp_CBE
42.04
33%
-4
- C3 -
-
4BN1
1
AURKA_HUMAN
A:
[13-270]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
M
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
T
--
L
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
508
Blastp_CBE
41.83
34%
-14
- C3 -
-
3NRM
1
AURKA_HUMAN
A:
[11-268]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
A
--
A
L
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
41.77
36%
-30
- C3 -
-
2JBO
1
MAPK2_HUMAN
A:
[32-293]
-------------------
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
----------------
Q
D
C
-
P
---
K
A
R
R
E
V
E
L
H
W
R
A
S
-
Q
C
-
P
H
I
V
R
I
V
D
V
Y
E
N
LY
A
G
R
K
-----
C
L
LI
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
----
A
-
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
-
K
--
E
T
T
---------
C
Y
T
P
Y
Y
V
A
P
E
V
L
-----
G
------
P
---
E
K
Y
-
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
------
Y
S
-
N
H
GLAI-
S
P
-
G
M
K
T
R
I
-
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
41.73
34%
-1
- C3 -
-
2WTW
1
AURKA_HUMAN
A:
[13-271]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
--------
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
343
Blastp_CBE
41.59
36%
-21
- C3 -
-
3LM5
1
ST17B_HUMAN
A:
[35-291]
----------------
K
E
-
L
-
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
K
R
R
-
R
--
G
------
Q
D
C
R
-
A
---
E
I
L
H
E
I
A
V
-
L
E
L
A
-
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
--
T
S
E
I
-----
I
L
--
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
E
L-
E
----
M
-
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
L
S
S
I
Y
P
L
G
D
I
K
I
V
D
F
G
M
S
-
R
--
K
----------
I
M
G
T
P
E
Y
L
A
P
E
I
L
-----
N
------
Y
---
D
P
I
-
T
T
A
-
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
------
V
G
-
E
D
-----
N
Q
-
E
T
Y
L
N
I
-
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
41.45
34%
-11
- C3 -
-
5L8J
5
AURKA_HUMAN
A:
[13-273]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
------------------
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
41.42
37%
-41
- C3 -
-
4QFR
2
?
A:
[18-401]
------------
Y
I
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
-
I
--
R
------
S
L
D
V
V
G
---
K
I
R
R
E
I
Q
N
-
L
K
L
F
-
R
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
S
D
I
-----
F
M
--
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
---
K
I
A
D
F
G
L
S
N
M
--
M
S
D
G
E
---
F
L
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
D
-
D
H
-----
V
P
-
T
L
F
K
K
I
-
C
D
G
I
--
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
41.36
39%
-22
- C3 -
-
4CZT
3
CIPKN_ARATH
A:
[12-270]
-----------
K
Y
E
L
G
R
T
-
L
-
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
--
K
------
N
K
M
I
-
A
---
Q
I
K
R
E
I
S
T
-
M
K
L
I
-
K
H
-
P
N
V
I
R
M
F
E
V
M
A
S
--
K
T
K
I
-----
Y
F
--
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
--
G
----
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
N
---
G
A
L
K
V
S
D
F
G
L
S
-
A
LP
Q
Q
V
R
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
-----
N
------
N
---
K
G
Y
D
G
A
K
-
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
------
E
D
-
S
N
-----
L
T
-
S
L
Y
K
K
I
F
K
A
---
E
F
T
C
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
524
Blastp_CBE
41.34
34%
-14
- C3 -
-
3H0Y
1
AURKA_HUMAN
A:
[8-265]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
------------------
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
40.89
38%
-24
- C3 -
-
2XM9
1
CHK2_HUMAN
A:
[16-284]
----------
D
E
Y
I
M
S
K
T
-
L
-
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------PAL
N
V
E
T
E
I
E
I
-
L
K
K
L
-
N
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
-
D
Y
-----
Y
I
--
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
----
K
I
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
40.72
38%
-23
- C3 -
-
4A9T
4
CHK2_HUMAN
A:
[16-284]
----------
D
E
Y
I
M
S
K
T
-
L
-
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------PAL
N
V
E
T
E
I
E
I
-
L
K
K
L
-
N
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
-
D
Y
-----
Y
I
--
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
----
K
I
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
557
Blastp_CBE
40.66
33%
-5
- C3 -
-
2C6D
2
AURKA_HUMAN
A:
[8-266]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
------------
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
40.36
37%
-42
- C3 -
-
6E4T
2
?
A:
[18-401]
------------
Y
I
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
-
I
--
R
------
S
L
D
V
V
G
---
K
I
R
R
E
I
Q
N
-
L
K
L
F
-
R
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
S
D
I
-----
F
M
--
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
---
K
I
A
D
F
G
L
S
N
M
--
M
S
D
G
E
---
F
L
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
D
-
D
H
-----
V
P
-
T
L
F
K
K
I
-
C
D
G
I
--
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
479
Blastp_CBE
40.02
37%
-40
- C3 -
-
6E4W
2
?
A:
[18-401]
------------
Y
I
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
-
I
--
R
------
S
L
D
V
V
G
---
K
I
R
R
E
I
Q
N
-
L
K
L
F
-
R
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
S
D
I
-----
F
M
--
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
---
K
I
A
D
F
G
L
S
N
M
--
M
S
D
G
E
---
F
L
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
D
-
D
H
-----
V
P
-
T
L
F
K
K
I
-
C
D
G
I
--
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
39.91
37%
-42
- C3 -
-
6E4U
2
AAPK1_RAT
A:
[18-397]
------------
Y
I
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
-
I
--
R
------
S
L
D
V
V
G
---
K
I
R
R
E
I
Q
N
-
L
K
L
F
-
R
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
S
D
I
-----
F
M
--
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
---
K
I
A
D
F
G
L
S
N
M
--
M
S
D
G
E
---
F
L
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
D
-
D
H
-----
V
P
-
T
L
F
K
K
I
-
C
D
G
I
--
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
39.79
36%
-24
- C3 -
-
2PZY
1
MAPK2_HUMAN
A:
[30-291]
-------------------
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
----------------
Q
D
C
-
P
---
K
A
R
R
E
V
E
L
H
W
R
A
S
-
Q
C
-
P
H
I
V
R
I
V
D
V
Y
E
N
LY
A
G
R
K
-----
C
L
LI
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
-------
A
-
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
-
K
--
E
T
------------
T
P
Y
Y
V
A
P
E
V
L
-----
G
------
P
---
E
K
Y
-
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
------
Y
S
-
N
H
GLAI-
S
P
-
G
M
K
T
R
I
-
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
39.78
38%
-8
- C3 -
-
4BDK
4
CHK2_HUMAN
A:
[16-284]
----------
D
E
Y
I
M
S
K
T
-
L
-
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------AL-
N
V
E
T
E
I
E
I
-
L
K
K
L
-
N
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
-
D
Y
-----
Y
I
--
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
----
K
I
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
488
Blastp_CBE
39.70
37%
-39
- C3 -
-
6C9J
2
AAPK1_HUMAN
A:
[16-368]
------------
Y
I
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
-
I
--
R
------
S
L
D
V
V
G
---
K
I
R
R
E
I
Q
N
-
L
K
L
F
-
R
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
S
D
I
-----
F
M
--
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
---
K
I
A
D
F
G
L
S
N
M
--
M
S
D
G
E
---
F
L
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
D
-
D
H
-----
V
P
-
T
L
F
K
K
I
-
C
D
G
I
--
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
39.67
33%
-31
- C3 -
-
4JXF
2
PLK4_HUMAN
A:
[7-264]
----------
E
D
F
K
V
G
N
L
-
L
-
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
-
M
Y-
K
------
A
G
M
V
-
Q
---
R
V
Q
N
E
V
K
I
-
H
C
Q
L
-
K
H
-
P
S
I
L
E
L
Y
N
Y
F
E
D
--
S
N
Y
V
-----
Y
L
--
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V-
K
----
P
-
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
M
N
---
I
K
I
A
D
F
G
L
A
-
T
--
Q
L
K
M
P
H
----------------------------------------
E
-
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
----------------
V
K
-
N
T
L
N
K
V
-
V
L
A
D
Y
E
M
P
S
----
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
39.65
36%
-39
- C3 -
-
2PZY
1
MAPK2_HUMAN
B:
[30-291]
-------------------
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
----------------
Q
D
C
-
P
---
K
A
R
R
E
V
E
L
H
W
R
A
S
-
Q
C
-
P
H
I
V
R
I
V
D
V
Y
E
N
LY
A
G
R
K
-----
C
L
LI
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
----
A
-
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
-
K
--
E
T
------------
T
P
Y
Y
V
A
P
E
V
L
-----
G
------
P
---
E
K
Y
-
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
------
Y
S
-----------
G
M
K
T
R
I
-
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
39.59
38%
-24
- C3 -
-
2WTD
4
CHK2_HUMAN
A:
[16-284]
----------
D
E
Y
I
M
S
K
T
-
L
-
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------PAL
N
V
E
T
E
I
E
I
-
L
K
K
L
-
N
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
-
D
Y
-----
Y
I
--
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
----
K
I
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
484
Blastp_CBE
39.58
37%
-40
- C3 -
-
5KQ5
2
?
A:
[18-399]
------------
Y
I
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
-
I
--
R
------
S
L
D
V
V
G
---
K
I
R
R
E
I
Q
N
-
L
K
L
F
-
R
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
S
D
I
-----
F
M
--
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
---
K
I
A
D
F
G
L
S
N
M
--
M
S
D
G
E
---
F
L
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
D
-
D
H
-----
V
P
-
T
L
F
K
K
I
-
C
D
G
I
--
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
374
Blastp_CBE
39.56
38%
-54
- C3 -
-
6B2E
2
AAPK2_HUMAN
A:
[29-381]
------------
Y
V
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
-
I
--
R
------
S
L
D
V
V
G
---
K
I
K
R
E
I
Q
N
-
L
K
L
F
-
R
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
T
D
F
-----
F
M
--
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
--
G
----
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
---
K
I
A
D
F
G
L
S
N
M
--
M
S
D
G
E
---
F
L
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
D
-
E
H
-----
V
P
-
T
L
F
K
K
I
-
R
G
G
V
F
Y
I
P
----
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
496
Blastp_CBE
39.52
37%
-43
- C3 -
-
4CFH
1
AAPK1_RAT
A:
[35-346]
------------
Y
I
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
-
I
--
R
------
S
L
D
V
V
G
---
K
I
R
R
E
I
Q
N
-
L
K
L
F
-
R
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
S
D
I
-----
F
M
--
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
---
K
I
A
D
F
G
L
S
N
M
--
M
S
D
G
E
---
F
L
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
D
-
D
H
-----
V
P
-
T
L
F
K
K
I
-
C
D
G
I
--
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
558
Blastp_CBE
39.36
34%
-12
- C3 -
-
5OSF
2
AURKA_HUMAN
A:
[5-265]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
39.29
36%
-22
- C3 -
-
2PZY
1
MAPK2_HUMAN
C:
[30-291]
-------------------
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
----------------
Q
D
C
-
P
---
K
A
R
R
E
V
E
L
H
W
R
A
S
-
Q
C
-
P
H
I
V
R
I
V
D
V
Y
E
N
LY
A
G
R
K
-----
C
L
LI
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
----
A
-
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
-
K
--
E
T
------------
T
P
Y
Y
V
A
P
E
V
L
-----
G
------
P
---
E
K
Y
-
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
------
Y
S
-
N
H
GLAI-
S
P
-
G
M
K
T
R
I
-
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
39.23
34%
-9
- C3 -
-
5OS5
2
AURKA_HUMAN
A:
[7-267]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
39.12
38%
-21
- C3 -
-
4A9U
10
CHK2_HUMAN
A:
[16-284]
----------
D
E
Y
I
M
S
K
T
-
L
-
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------------
D
PAL
N
V
E
T
E
I
E
I
-
L
K
K
L
-
N
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
-
D
Y
-----
Y
I
--
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
----
K
I
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
529
Blastp_CBE
39.08
34%
-9
- C3 -
-
5OSD
2
AURKA_HUMAN
A:
[7-267]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
571
Blastp_CBE
39.05
34%
-9
- C3 -
-
5ORS
2
AURKA_HUMAN
A:
[5-265]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
560
Blastp_CBE
39.01
34%
-9
- C3 -
-
5OS6
2
AURKA_HUMAN
A:
[5-265]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
38.98
37%
-41
- C3 -
-
4QFS
2
A:
[18-401]
------------
Y
I
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
-
I
--
R
------
S
L
D
V
V
G
---
K
I
R
R
E
I
Q
N
-
L
K
L
F
-
R
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
S
D
I
-----
F
M
--
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
---
K
I
A
D
F
G
L
S
N
M
--
M
S
D
G
E
---
F
L
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
D
-
D
H
-----
V
P
-
T
L
F
K
K
I
-
C
D
G
I
--
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
569
Blastp_CBE
38.97
34%
-9
- C3 -
-
5ORV
2
AURKA_HUMAN
A:
[5-265]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
497
Blastp_CBE
38.97
34%
-10
- C3 -
-
6R4D
2
AURKA_HUMAN
A:
[13-273]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
559
Blastp_CBE
38.85
34%
-10
- C3 -
-
5OSE
2
AURKA_HUMAN
A:
[5-265]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
576
Blastp_CBE
38.83
34%
-12
- C3 -
-
5ORL
2
AURKA_HUMAN
A:
[5-265]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
564
Blastp_CBE
38.81
34%
-11
- C3 -
-
5OS0
2
AURKA_HUMAN
A:
[5-265]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
574
Blastp_CBE
38.79
34%
-10
- C3 -
-
5ORO
2
AURKA_HUMAN
A:
[5-265]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
38.76
34%
-10
- C3 -
-
6R4C
2
AURKA_HUMAN
A:
[13-273]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
38.74
38%
-26
- C3 -
-
2WTC
1
CHK2_HUMAN
A:
[16-284]
----------
D
E
Y
I
M
S
K
T
-
L
-
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------PAL
N
V
E
T
E
I
E
I
-
L
K
K
L
-
N
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
-
D
Y
-----
Y
I
--
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
----
K
I
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
568
Blastp_CBE
38.71
34%
-8
- C3 -
-
5ORW
2
AURKA_HUMAN
A:
[5-265]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
38.71
38%
-6
- C3 -
-
2XBJ
1
CHK2_HUMAN
A:
[16-284]
----------
D
E
Y
I
M
S
K
T
-
L
-
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------AL-
N
V
E
T
E
I
E
I
-
L
K
K
L
-
N
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
-
D
Y
-----
Y
I
--
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
----
K
I
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
563
Blastp_CBE
38.67
34%
-9
- C3 -
-
5OS1
2
AURKA_HUMAN
A:
[5-265]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
499
Blastp_CBE
38.66
34%
-11
- C3 -
-
6R4B
1
AURKA_HUMAN
A:
[13-273]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
565
Blastp_CBE
38.65
34%
-11
- C3 -
-
5ORZ
2
AURKA_HUMAN
A:
[5-265]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
38.59
38%
-12
- C3 -
-
4BDE
5
CHK2_HUMAN
A:
[16-284]
----------
D
E
Y
I
M
S
K
T
-
L
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------------AL-
N
V
E
T
E
I
E
I
-
L
K
K
L
-
N
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
-
D
Y
-----
Y
I
--
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
----
K
I
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
573
Blastp_CBE
38.51
34%
-11
- C3 -
-
5ORP
2
AURKA_HUMAN
A:
[5-265]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
506
Blastp_CBE
38.47
34%
-12
- C3 -
-
4CEG
3
AURKA_HUMAN
A:
[13-273]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
575
Blastp_CBE
38.39
34%
-9
- C3 -
-
5ORN
2
AURKA_HUMAN
A:
[5-265]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
567
Blastp_CBE
38.38
34%
-11
- C3 -
-
5ORX
2
AURKA_HUMAN
A:
[5-265]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
38.36
34%
-8
- C3 -
-
5G1X
1
AURKA_HUMAN
A:
[13-271]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
566
Blastp_CBE
38.35
34%
-12
- C3 -
-
5ORY
2
AURKA_HUMAN
A:
[5-265]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
562
Blastp_CBE
38.29
34%
-10
- C3 -
-
5OS3
2
AURKA_HUMAN
A:
[5-265]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
495
Blastp_CBE
38.23
34%
-9
- C3 -
-
5LXM
6
AURKA_HUMAN
A:
[11-272]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
N
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
500
Blastp_CBE
38.17
34%
-10
- C3 -
-
6R4A
4
AURKA_HUMAN
A:
[13-273]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
561
Blastp_CBE
38.12
34%
-10
- C3 -
-
5OS4
2
AURKA_HUMAN
A:
[5-265]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
572
Blastp_CBE
38.09
34%
-9
- C3 -
-
5ORR
2
AURKA_HUMAN
A:
[5-265]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
460
Blastp_CBE
37.94
36%
-39
- C3 -
-
2P3G
1
MAPK2_HUMAN
X:
[26-287]
-------------------
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
----------------
Q
D
C
-
P
---
K
A
R
R
E
V
E
L
H
W
R
A
S
-
Q
C
-
P
H
I
V
R
I
V
D
V
Y
E
N
LY
A
G
R
K
-----
C
L
LI
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
----
A
-
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
-
K
--
E
T
T
S
-------------------------------------
K
Y
-
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
------
Y
S
--------------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
570
Blastp_CBE
37.87
34%
-10
- C3 -
-
5ORT
2
AURKA_HUMAN
A:
[5-265]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
37.81
36%
-13
- C3 -
-
1NY3
1
MAPK2_HUMAN
A:
[70-331]
-------------------
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
----------------
Q
D
C
-
P
---
K
A
R
R
E
V
E
L
H
W
R
A
S
-
Q
C
-
P
H
I
V
R
I
V
D
V
Y
E
N
LY
A
G
R
K
-----
C
L
LI
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
-----------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
-
K
--
E
T
T
S
-
H
---------
P
Y
Y
V
A
P
E
V
L
-----
G
------
P
---
E
K
Y
-
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
------
Y
S
-----------
G
M
K
T
R
I
-
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
37.71
36%
-38
- C3 -
-
3FYK
1
MAPK2_HUMAN
X:
[26-287]
-------------------
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
----------------
Q
D
C
-
P
---
K
A
R
R
E
V
E
L
H
W
R
A
S
-
Q
C
-
P
H
I
V
R
I
V
D
V
Y
E
N
LY
A
G
R
K
-----
C
L
LI
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
----
A
-
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
-
K
--
E
T
T
S
-------------------------------------
K
Y
-
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
------
Y
S
--------------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
37.60
36%
-12
- C3 -
-
3R30
1
MAPK2_HUMAN
A:
[25-286]
-------------------
L
-
G
L
G
I
-
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
----------------
Q
D
C
-
P
---
K
A
R
R
E
V
E
L
H
W
R
A
S
-
Q
C
-
P
H
I
V
R
I
V
D
V
Y
E
N
LY
A
G
R
K
-----
C
L
LI
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
-----------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
-
K
--
E
T
T
---------------------------------
P
---
E
K
Y
-
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
------
Y
S
-----------
G
M
K
T
R
I
-
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
37.18
34%
-9
- C3 -
-
5L8K
9
AURKA_HUMAN
A:
[13-274]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
T
---
L
A
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
N
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
37.07
36%
-20
- C3 -
-
3FXW
1
MAPK3_HUMAN
A:
[27-297]
---------
T
D
D
Y
Q
L
S
K
Q
V
L
-
G
L
G
V
-
G
K
V
L
E
C
F
H
R
R
T
G
Q
K
C
A
L
K
L
L
Y
D
------
S
------
P
K
A
R
-
Q
---
E
V
D
H
H
W
Q
A
-
S
----
G
G
-
P
H
I
V
C
I
L
D
-
V
Y
E
--
N
M
H
H
GKRCL
L
I
--
I
M
E
C
M
E
G
G
E
L
F
S
R
I
Q
E
R
D-
Q
----
A
-
F
T
E
R
E
A
A
E
I
M
R
D
I
G
T
A
I
Q
F
L
H
S
H
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
E
K
D
A
V
L
K
L
T
D
F
G
F
A
-
K
--
E
---------------------------------------
E
K
Y
-
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
F
P
P
F
-------------------------------
G
F
P
N
P
E
W
S
E
V
S
E
D
A
K
Q
L
I
R
L
L
L
K
T
D
P
T
E
R
L
T
I
T
Q
F
M
N
H
P
W
I
N
Q
S
M
V
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
36.76
36%
-37
- C3 -
-
3FYJ
1
MAPK2_HUMAN
X:
[26-287]
-------------------
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
----------------
Q
D
C
-
P
---
K
A
R
R
E
V
E
L
H
W
R
A
S
-
Q
C
-
P
H
I
V
R
I
V
D
V
Y
E
N
LY
A
G
R
K
-----
C
L
LI
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
----
A
-
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
-
K
--
E
T
T
S
-------------------------------------
K
Y
-
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
------
Y
S
--------------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
35.85
34%
0
- C3 -
-
2WTV
9
AURKA_HUMAN
B:
[13-271]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
-----
L
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
510
Blastp_CBE
35.80
34%
-2
- C3 -
-
2WTV
5
AURKA_HUMAN
C:
[13-271]
----------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
EK
A
------
G
V
E
H
-
Q
----
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
--
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
---
A
G
E
L
K
I
A
D
F
G
W
S
-
V
--
H
A
P
S
S
R
R
-----
L
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
A
-
N
T
-----
Y
Q
-
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
35.14
36%
-7
- C3 -
-
3R2Y
1
MAPK2_HUMAN
A:
[25-286]
-------------------
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
----------------
Q
D
C
-
P
---
K
A
R
R
E
V
E
L
H
W
R
A
S
-
Q
C
-
P
H
I
V
R
I
V
D
V
Y
E
N
LY
A
G
R
K
-----
C
L
LI
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
-----------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
-
K
--
E
T
T
-----------------------------------------
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
------
Y
-------------
M
K
T
R
I
-
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
33.71
33%
-49
- C3 -
-
5WVD
1
MKNK1_HUMAN
B:
[12-302]
-------
K
F
E
D
M
Y
K
L
T
S
E
-
L
L
G
E
G
A
Y
A
K
V
Q
G
A
V
S
L
Q
N
G
K
E
Y
A
V
K
I
I
E
K
Q
A
-
G
--
H
------
S
R
S
R
-
V
---
F
R
E
V
E
T
-
L
-
Y
Q
C
Q
-
G
N
-
K
N
I
L
E
L
I
E
F
F
E
D
--
D
T
R
F
-----
Y
L
--
V
F
E
K
L
Q
G
G
S
I
L
A
H
I
Q
----------------
A
S
R
V
V
R
D
V
A
A
A
L
D
F
L
H
T
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
S
P
--
V
S
P
V
K
I
C
D
F
D
L
G
-
S
--
G
M
--------------
E
Y
M
A
P
E
V
V
EVFTD
Q
------
A
---
T
F
Y
-
D
K
R
-
C
D
L
W
S
L
G
V
V
L
Y
I
M
L
S
G
Y
P
------------------------------------------------
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------