@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KCC2D_HUMAN: (2020-09-12 )
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPPCIPNGKENFSGGTSLWQNI
Atome Classification :
(282 SA)
........-.10........-20.........30........40...--....---.-50-.------..----..---------.---...----60...-....-.-70.........80.--....-----...90........100...--.----.-..110.......120.......130.......140......-.-150-.-.......160-........170--...-....180....-----.------.---.190...-.....200.......210..------.---.-.--.-----.220-----......-...230.......240.......250.......260.......270----.----...----...280.---.......290------.........300------.......---.310......-----..-320.......330.......-----340.......350.-......360.......370.......380.......390.......400.......410.......420.......430.......440..-.....450.......460.......470.......480.......490.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAST
T
T
C
T
-RF
T
D
E
Y
Q
L
F
E
E
-L-
G
K
G
A
F
S
V
V
R
R
C
M
KIPT
G
Q
E
Y
A
A
K
I
--
I
NTK---K-L--S------
A
R
----
D
H
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
L
L-K-H-P
N
I
V
R
LHDSISE--EG
F
H
-----
Y
L
V
F
D
LVT
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-YSEA
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
CHLN
G
I
V
HRDLKPE
N
L
L
L
ASKS-K-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
QGDQ
Q
A
W
F--GFA-GTPGYL
S
P
E
V
L-----R------K---DPY-GK
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
VGYPPF------W---D-
E
--
D
-----
Q
H
-------
R
L
Y
Q
Q
I
-
K
AGAYDFPSPEWDTVTP
E
A
K
D
L
I
N
K
M
LTINPAKRI
T
A
S
E
ALKHPWI----C----
Q
R
S
----
T
V
A
S
M
-
M
---
H
R
Q
E
T
V
D
C
--------
L
K
K
F
N
A
R
R
K
L
K
-------
G
A
I
L
T
T
M
---
L
A-TR
N
F
S
A
A
-----
K
S
-
L
LKKPDGVKESTESSNTTIE-----
D
E
D
V
K
A
R
K
Q
E
I
I
K
V
-
T
E
Q
L
I
E
A
I
NNG
D
F
E
A
Y
T
KICDPGLTAF
E
P
E
A
L
G
N
L
V
E
G
M
D
F
H
R
F
Y
F
E
N
A
LSKSNK
P
I
H
T
I
I
LNP
H
V
H
L
VGD
D
A
A
C
I
A
Y
I
R
L
T
Q
YMDGSGMP-KTMQSEET
R
V
W
HRRDGKWQ
N
V
H
F
HRSGSPTVPIKPPCIPNGKENFSG
G
T
S
L
W
QNI
1
PsiBlast_PDB
94.32
88%
-95
- C2 -
-
5U6Y
-
KCC2A_RAT
A:
[2-461]
--------------
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
-
L
--
S
------
A
R
----
D
H
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
H
H
-----
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
L
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
E
G
E
Q
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
----
S
----
H
R
S
----
T
V
A
S
C
-
M
---
H
R
Q
E
T
V
D
C
--------
L
K
K
F
N
A
R
R
K
L
K
-------
G
A
I
L
T
T
M
---
L
A
-
T
R
N
F
S
G
G
-----
K
S
G
G
N
K
K
S
D
G
V
K
E
S
S
E
S
T
N
T
T
I
E
-----
D
E
D
T
K
V
R
K
Q
E
I
I
K
V
-
T
E
Q
L
I
E
A
I
S
N
G
D
F
E
S
Y
T
K
M
C
D
P
G
M
T
A
F
E
P
E
A
L
G
N
L
V
E
G
L
D
F
H
R
F
Y
F
E
N
L
W
S
--
S
K
P
V
H
T
T
I
L
N
P
H
I
H
L
M
G
D
E
S
A
C
I
A
Y
I
R
I
T
Q
Y
L
D
A
G
G
I
P
-
R
T
A
Q
S
E
E
T
R
V
W
H
R
R
D
G
K
W
Q
I
V
H
F
H
R
S
G
A
---------------------------
590
HHSearch
93.03
88%
-93
- C2 -
-
5U6Y
-
KCC2A_RAT
J:
[2-461]
--------------
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
-
L
--
S
------
A
R
----
D
H
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
H
H
-----
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
L
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
E
G
E
Q
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
----
S
----
H
R
S
----
T
V
A
S
C
-
M
---
H
R
Q
E
T
V
D
C
--------
L
K
K
F
N
A
R
R
K
L
K
-------
G
A
I
L
T
T
M
---
L
A
-
T
R
N
F
S
G
G
-----
K
S
G
G
N
K
K
S
D
G
V
K
E
S
S
E
S
T
N
T
T
I
E
-----
D
E
D
T
K
V
R
K
Q
E
I
I
K
V
-
T
E
Q
L
I
E
A
I
S
N
G
D
F
E
S
Y
T
K
M
C
D
P
G
M
T
A
F
E
P
E
A
L
G
N
L
V
E
G
L
D
F
H
R
F
Y
F
E
N
L
W
S
--
S
K
P
V
H
T
T
I
L
N
P
H
I
H
L
M
G
D
E
S
A
C
I
A
Y
I
R
I
T
Q
Y
L
-
D
A
G
G
I
P
R
T
A
Q
S
E
E
T
R
V
W
H
R
R
D
G
K
W
Q
I
V
H
F
H
R
S
G
A
---------------------------
592
HHSearch
89.31
88%
-93
- C2 -
-
3SOA
1
KCC2A_HUMAN
A:
[7-443]
-------
T
-
R
F
T
E
E
Y
Q
L
F
E
E
-
L
-
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
--
I
N
T
K
---
K
-
L
--
S
------
A
R
----
D
H
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
H
H
-----
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
L
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
E
G
E
Q
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
----
S
----
H
R
S
----
T
V
A
S
C
-
M
---
H
R
Q
E
T
V
D
C
--------
L
K
K
F
N
A
R
R
K
L
K
-------
G
A
I
L
T
V
M
---
L
A
-
T
R
----------------------------------------
N
F
S
V
R
K
Q
E
I
I
K
V
-
T
E
Q
L
I
E
A
I
S
N
G
D
F
E
S
Y
T
K
M
C
D
P
G
M
T
A
F
E
P
E
A
L
G
N
L
V
E
G
L
D
F
H
R
F
Y
F
E
N
L
W
S
R
N
S
K
P
V
H
T
T
I
L
N
P
H
I
H
L
M
G
D
E
S
A
C
I
A
Y
I
R
I
T
Q
Y
L
D
A
G
G
I
P
-
R
T
A
Q
S
E
E
T
R
V
W
H
R
R
D
G
K
W
Q
I
V
H
F
H
R
S
G
A
P
--------------------------
2
PsiBlast_PDB
87.77
82%
-92
- C2 -
-
3SOA
1
KCC2A_HUMAN
A:
[7-444]
-------
T
-
R
F
T
E
E
Y
Q
L
F
E
E
-
L
-
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
--
I
N
T
K
---
K
-
L
--
S
------
A
R
----
D
H
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
H
H
-----
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
L
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
E
G
E
Q
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
----
S
----
H
R
S
----
T
V
A
S
C
-
M
---
H
R
Q
E
T
V
D
C
--------
L
K
K
F
N
A
R
R
K
L
K
-------
G
A
I
L
T
V
M
---
L
A
-
T
R
N
F
S
----------------------------------------
V
R
K
Q
E
I
I
K
V
-
T
E
Q
L
I
E
A
I
S
N
G
D
F
E
S
Y
T
K
M
C
D
P
G
M
T
A
F
E
P
E
A
L
G
N
L
V
E
G
L
D
F
H
R
F
Y
F
E
N
L
W
S
R
N
S
K
P
V
H
T
T
I
L
N
P
H
I
H
L
M
G
D
E
S
A
C
I
A
Y
I
R
I
T
Q
Y
L
D
A
G
G
I
P
-
R
T
A
Q
S
E
E
T
R
V
W
H
R
R
D
G
K
W
Q
I
V
H
F
H
R
S
G
A
P
S
-------------------------
593
HHSearch
76.48
100%
-130
- C2 -
-
2WEL
7
KCC2D_HUMAN
A:
[2-308]
----------
M
T
D
E
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
-
L
--
S
------
A
R
----
D
H
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
D
Q
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
----
C
----
Q
R
--------
S
M
-
M
---
H
R
Q
E
T
V
D
C
--------
L
K
K
F
N
A
R
R
K
L
K
-------
G
A
I
L
T
T
M
---
L
A
-
T
R
N
F
S
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.32
99%
-130
- C2 -
-
2WEL
7
KCC2D_HUMAN
A:
[2-308]
----------
M
T
D
E
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
-
L
--
S
------
A
R
----
D
H
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
D
Q
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
----
C
----
Q
R
--------
S
M
-
M
---
H
R
Q
E
T
V
D
C
--------
L
K
K
F
N
A
R
R
K
L
K
-------
G
A
I
L
T
T
M
---
L
A
-
T
R
N
F
S
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
595
HHSearch
76.10
100%
-117
- C2 -
-
2VN9
2
KCC2D_HUMAN
A:
[2-300]
----------
M
T
D
E
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
-
L
--
S
------
A
R
----
D
H
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
D
Q
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
----
C
----
Q
R
S
----
T
V
A
S
M
-
M
---
H
R
Q
E
T
V
D
C
--------
L
K
K
F
N
A
R
R
K
L
K
-------
G
A
I
L
T
T
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
75.81
99%
-117
- C2 -
-
2VN9
2
KCC2D_HUMAN
A:
[2-301]
----------
M
T
D
E
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
-
L
--
S
------
A
R
----
D
H
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
D
Q
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
----
C
----
Q
R
S
----
T
V
A
S
M
-
M
---
H
R
Q
E
T
V
D
C
--------
L
K
K
F
N
A
R
R
K
L
K
-------
G
A
I
L
T
T
M
---
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
75.08
99%
-117
- C2 -
-
2VN9
1
KCC2D_HUMAN
B:
[2-301]
----------
M
T
D
E
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
-
L
--
S
------
A
R
----
D
H
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
D
Q
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
----
C
----
Q
R
S
----
T
V
A
S
M
-
M
---
H
R
Q
E
T
V
D
C
--------
L
K
K
F
N
A
R
R
K
L
K
-------
G
A
I
L
T
T
M
---
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
74.56
100%
-116
- C2 -
-
6AYW
2
KCC2D_HUMAN
B:
[8-300]
------
C
T
-
R
F
T
D
E
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
-
L
--
S
------
A
R
----
D
H
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
D
Q
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
----
C
----
Q
R
S
----
T
V
A
S
M
-
M
---
H
R
Q
E
T
V
D
C
--------
L
K
K
F
N
A
R
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
74.53
100%
-117
- C2 -
-
6AYW
2
KCC2D_HUMAN
A:
[9-301]
-------
T
-
R
F
T
D
E
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
-
L
--
S
------
A
R
----
D
H
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
D
Q
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
----
C
----
Q
R
S
----
T
V
A
S
M
-
M
---
H
R
Q
E
T
V
D
C
--------
L
K
K
F
N
A
R
R
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
74.04
100%
-112
- C2 -
-
5VLO
2
KCC2D_HUMAN
B:
[8-300]
------
C
T
-
R
F
T
D
E
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
-
L
--
S
------
A
R
----
D
H
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
D
Q
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
----
C
----
Q
R
S
----
T
V
A
S
M
-
M
---
H
R
Q
E
T
V
D
C
--------
L
K
K
F
N
A
R
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
73.95
92%
-119
- C2 -
-
2VZ6
3
KCC2A_HUMAN
B:
[20-311]
----------
F
Q
S
M
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
-
L
--
S
------
A
R
----
D
H
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
H
H
-----
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
L
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
E
G
E
Q
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
----
S
----
H
R
S
----
T
V
A
S
C
-
M
---
H
R
Q
E
T
V
D
C
--------
L
K
K
F
N
A
R
R
K
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
73.81
92%
-122
- C2 -
-
2VZ6
2
KCC2A_HUMAN
A:
[20-310]
----------
F
Q
S
M
Y
Q
L
F
E
E
-
L
-
G
K
--
F
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
-
L
--
S
------
A
R
----
D
H
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
H
H
-----
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
L
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
E
G
E
Q
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
----
S
----
H
R
S
----
T
V
A
S
C
-
M
---
H
R
Q
E
T
V
D
C
--------
L
K
K
F
N
A
R
R
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.41
100%
-114
- C2 -
-
5VLO
2
KCC2D_HUMAN
A:
[9-301]
-------
T
-
R
F
T
D
E
Y
Q
L
F
E
E
-
L
-
G
---
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
-
L
--
S
------
A
R
----
D
H
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
D
Q
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
----
C
----
Q
R
S
----
T
V
A
S
M
-
M
---
H
R
Q
E
T
V
D
C
--------
L
K
K
F
N
A
R
R
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
73.31
91%
-115
- C2 -
-
2V7O
3
KCC2G_HUMAN
A:
[25-321]
-----
T
C
T
-
R
F
T
D
D
Y
Q
L
F
E
E
-
L
-
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
-
L
--
S
------
A
R
----
D
H
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
E
Q
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
K
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
V
----
C
----
Q
R
S
----
T
V
A
S
M
-
M
---
H
R
Q
E
T
V
E
C
--------
L
R
K
F
N
A
R
R
K
L
K
-------
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
73.17
91%
-123
- C2 -
-
3BHH
1
KCC2B_HUMAN
A:
[2-293]
----------
M
T
D
E
Y
Q
L
Y
E
D
-
I
-
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
--
I
N
T
K
---
K
-
L
--
S
------
A
R
----
D
H
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
L
L
-
K
-
H
-
S
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
D
Q
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
E
A
Y
-
G
K
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
K
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
----
C
----
Q
R
S
----
T
V
A
S
M
-
M
---
H
R
Q
E
T
V
E
C
--------
L
K
K
F
N
A
R
R
K
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
73.09
92%
-122
- C2 -
-
3BHH
1
KCC2B_HUMAN
B:
[2-293]
----------
M
T
D
E
Y
Q
L
Y
E
D
-
I
-
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
--
I
N
T
K
---
K
-
L
--
S
------
A
R
----
D
H
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
L
L
-
K
-
H
-
S
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
D
Q
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
E
A
Y
-
G
K
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
K
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
H
E
A
L
K
H
P
W
V
----
C
----
Q
R
S
----
T
V
A
S
M
-
M
---
H
R
Q
E
T
V
E
C
--------
L
K
K
F
N
A
R
R
K
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
72.52
100%
-110
- C2 -
-
6BAB
1
KCC2D_MOUSE
D:
[10-301]
-----------
T
D
E
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
-
L
--
S
------
A
R
----
D
H
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
D
Q
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
----
C
----
Q
R
S
----
T
V
A
S
M
-
M
---
H
R
Q
E
T
V
D
C
--------
L
K
K
F
N
A
R
R
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
72.22
100%
-112
- C2 -
-
6BAB
3
KCC2D_MOUSE
C:
[14-301]
-------------
E
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
----
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
-
L
--
S
------
A
R
----
D
H
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
D
Q
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
----
C
----
Q
R
S
----
T
V
A
S
M
-
M
---
H
R
Q
E
T
V
D
C
--------
L
K
K
F
N
A
R
R
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
72.22
100%
-110
- C2 -
-
6BAB
2
KCC2D_MOUSE
A:
[12-301]
-----------
T
D
E
Y
Q
L
F
E
E
-
L
-
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
-
L
--
S
------
A
R
----
D
H
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
D
Q
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
----
C
----
Q
R
S
----
T
V
A
S
M
-
M
---
H
R
Q
E
T
V
D
C
--------
L
K
K
F
N
A
R
R
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
72.14
100%
-112
- C2 -
-
6BAB
2
KCC2D_MOUSE
B:
[14-302]
-------------
E
Y
Q
L
F
E
E
-
L
-
G
----
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
--
I
N
T
K
---
K
-
L
--
S
------
A
R
----
D
H
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
L
L
-
K
-
H
-
P
N
I
V
R
L
H
D
S
I
S
E
--
E
G
F
H
-----
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
D
Q
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
R
------
K
---
D
P
Y
-
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
R
L
Y
Q
Q
I
-
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
----
C
----
Q
R
S
----
T
V
A
S
M
-
M
---
H
R
Q
E
T
V
D
C
--------
L
K
K
F
N
A
R
R
K
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
69.19
84%
-122
- C2 -
-
5FG8
3
KCC2A_DROME
A:
[9-277]
------
C
T
-
R
F
S
D
N
Y
D
I
K
E
E
-
L
-
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
--
I
N
T
K
---
K
-
L
--
T
------
A
R
----
D
F
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
K
L
-
H
-
H
-
P
N
I
V
R
L
H
D
S
I
Q
E
--
E
N
Y
H
-----
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
F
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
A
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
D
H
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
K
------
K
---
E
P
Y
-
G
K
S
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
R
L
Y
S
Q
I
-
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
T
A
A
E
A
L
K
H
P
W
I
----
C
----
Q
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
67.99
84%
-120
- C2 -
-
5HU3
1
KCC2A_DROME
A:
[9-274]
------
C
T
-
R
F
S
D
N
Y
D
I
K
E
E
-
L
-
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
--
I
N
T
K
---
K
-
L
--
T
------
A
R
----
D
F
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
K
L
-
H
-
H
-
P
N
I
V
R
L
H
D
S
I
Q
E
--
E
N
Y
H
-----
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
F
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
A
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
D
H
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
K
------
K
---
E
P
Y
-
G
K
S
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
R
L
Y
S
Q
I
-
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
T
A
A
E
A
L
K
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
67.76
84%
-118
- C2 -
-
5H9B
2
KCC2A_DROME
A:
[9-277]
------
C
T
-
R
F
S
D
N
Y
D
I
K
E
E
-
L
-
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
--
I
N
T
K
---
K
-
L
--
T
------
A
R
----
D
F
---------
Q
---
K
L
E
----
R
E
A
R
I
-
C
R
K
L
-
H
-
H
-
P
N
I
V
R
L
H
D
S
I
Q
E
--
E
N
Y
H
-----
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
----
F
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
A
-
K
-
G
-
A
-
A
-
V
K
L
A
D
F
G
L
A
--
I
E
V
Q
G
D
H
Q
A
W
F
--
G
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
-----
K
------
K
---
E
P
Y
-
G
K
S
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
---
D
-
E
--
D
-----
Q
H
-------
R
L
Y
S
Q
I
-
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
T
A
A
E
A
L
K
H
P
W
I
----
C
----
Q
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
61.39
40%
-120
- C2 -
-
3LIJ
1
?
A:
[26-338]
M
F
I
T
S
K
K
G
-
H
L
S
E
M
Y
Q
R
V
K
K
-
L
-
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
--
I
R
K
-----------------
S
----
S
N
---------
S
---
K
L
L
----
E
E
V
A
V
-
L
K
L
L
-
D
-
H
-
P
N
I
M
K
L
Y
D
F
F
E
D
--
K
R
N
Y
-----
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
--
M
----
K
-
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
E
-
K
-
D
-
A
-
L
-
I
K
I
V
D
F
G
L
S
--
A
-
V
F
E
N
Q
K
K
M
K
--
E
R
L
-
G
T
A
Y
Y
I
A
P
E
V
L
-----
R
------
K
----
K
Y
-
D
E
K
-
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
------
G
---
G
-
Q
--
T
-----
D
Q
-------
E
I
L
R
K
V
-
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
KEMC
S
----
K
K
E
----
S
---
L
-
P
---
S
L
A
N
A
I
E
N
--------
M
R
K
F
Q
N
S
Q
K
L
A
-------
Q
A
A
L
L
Y
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
59.34
42%
-123
- C2 -
-
6T6F
1
?
A:
[16-322]
--------------
F
E
F
K
E
T
-
L
-
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
--
I
P
K
K
---
A
-
L
--
K
------
G
K
----
E
----------
S
---
S
I
E
----
N
E
I
A
V
-
L
R
K
I
-
K
-
H
-
E
N
I
V
A
L
E
D
I
Y
E
S
--
P
N
H
L
-----
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
--
G
----
F
-
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
Q
D
-
E
-
E
-
S
-
K
-
I
M
I
S
D
F
G
L
S
---------------------
P
G
Y
V
A
P
E
V
L
-----
A
------
Q
---
K
P
Y
-
S
K
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
---
D
-
E
--
N
-----
D
S
-------
K
L
F
E
Q
I
-
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
----
A
----
G
D
T
----
A
L
N
K
N
-
I
---
H
E
S
V
S
A
Q
I
--------
R
K
N
F
-
A
K
S
K
-
R
-------
Q
A
F
N
A
T
A
---
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
59.32
40%
-114
- C2 -
-
3MWU
1
?
A:
[20-340]
----------
F
A
E
R
Y
N
I
V
C
M
-
L
-
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
A
---
S
-
A
--
K
------
N
K
----
D
T
---------
S
---
T
I
L
----
R
E
V
E
L
-
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
--
S
S
S
F
-----
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
--
K
----
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
-
D
-
C
-
D
-
I
K
I
I
D
F
G
L
S
--
T
C
F
Q
Q
N
-------
D
R
I
-
G
T
A
Y
Y
I
A
P
E
V
L
-----
R
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
------
Y
---
G
-
K
--
N
-----
E
Y
-------
D
I
L
K
R
V
-
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
----
Q
----
K
Y
S
SETP
T
I
S
D
L
-
P
---
S
L
E
S
A
M
T
N
--------
I
R
Q
F
Q
A
E
K
K
L
A
-------
Q
A
A
L
L
Y
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
59.12
38%
-88
- C2 -
-
3HX4
3
?
A:
[48-389]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
----------------------
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
---
K
E
Q
I
S
V
D
V
--------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
-----
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
59.09
43%
-145
- C2 -
-
4FG7
1
KCC1A_HUMAN
A:
[18-277]
------------
D
I
Y
D
F
R
D
V
-
L
-
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
--------------------------------------
S
M
E
----
N
E
I
A
V
-
L
H
K
I
-
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
--
G
G
H
L
-----
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
--
G
----
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
-
D
-
S
-
K
-
I
M
I
S
D
F
G
L
S
---
K
M
E
D
P
-----------
G
T
P
G
Y
V
A
P
E
V
L
-----
A
------
Q
---
K
---
S
K
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
---
D
-
E
--
N
-----
D
A
-------
K
L
F
E
Q
I
-
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
59.01
40%
-113
- C2 -
-
3NCG
1
?
A:
[20-357]
----------
F
A
E
R
Y
N
I
V
C
M
-
L
-
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
A
---
S
-
A
--
K
------
N
K
----
D
T
---------
S
---
T
I
L
----
R
E
V
E
L
-
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
--
S
S
S
F
-----
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
--
K
----
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
-
D
-
C
-
D
-
I
K
I
I
D
F
G
L
S
--
T
C
F
Q
Q
N
T
--------
I
-
G
T
A
Y
Y
I
A
P
E
V
L
-----
R
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
------
Y
---
G
-
K
--
N
-----
E
Y
-------
D
I
L
K
R
V
-
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
----
Q
----
K
Y
S
SETP
T
I
S
D
L
-
P
---
S
L
E
S
A
M
T
N
--------
I
R
Q
F
Q
A
E
K
K
L
A
-------
Q
A
A
L
L
Y
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
58.96
42%
-134
- C2 -
-
4FG8
1
KCC1A_HUMAN
B:
[18-299]
------------
D
I
Y
D
F
R
D
V
-
L
-
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
--------------------------------------------
N
E
I
A
V
-
L
H
K
I
-
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
--
G
G
H
L
-----
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
--
G
----
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
-
D
-
S
-
K
-
I
M
I
S
D
F
G
----------
G
S
V
L
S
--
T
A
C
-
G
T
P
G
Y
V
A
P
E
V
L
-----
A
------
Q
---
K
P
Y
-
S
K
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
---
D
-
E
--
N
-----
D
A
-------
K
L
F
E
Q
I
-
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
----
A
----
G
D
T
----
A
L
D
K
N
-
I
---
H
-
Q
S
V
S
E
Q
--------
I
K
K
N
F
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
58.90
42%
-125
- C2 -
-
6T6F
1
?
B:
[16-322]
--------------
F
E
F
K
E
T
-
L
-
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
--
I
P
K
K
---
A
-
L
--
K
------
G
K
----
E
----------
S
---
S
I
E
----
N
E
I
A
V
-
L
R
K
I
-
K
-
H
-
E
N
I
V
A
L
E
D
I
Y
E
S
--
P
N
H
L
-----
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
--
G
----
F
-
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
Q
D
-
E
-
E
-
S
-
K
-
I
M
I
S
D
F
G
-----------------------
P
G
Y
V
A
P
E
V
L
-----
A
------
Q
---
K
P
Y
-
S
K
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
---
D
-
E
--
N
-----
D
S
-------
K
L
F
E
Q
I
-
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
E
Q
A
A
R
H
P
W
I
----
A
----
G
D
T
----
A
L
N
K
N
-
I
---
H
E
S
V
S
A
Q
I
--------
R
K
N
F
-
A
K
S
K
-
R
-------
Q
A
F
N
A
T
A
---
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
58.70
40%
-106
- C2 -
-
4Y5Q
1
?
A:
[20-340]
----------
F
A
E
R
Y
N
I
V
C
M
-
L
-
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
A
---
S
-
A
--
K
------
N
K
----
D
T
---------
S
---
T
I
L
----
R
E
V
E
L
-
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
--
S
S
S
F
-----
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
--
K
----
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
-
D
-
C
-
D
-
I
K
I
I
D
F
G
L
S
--
T
C
F
Q
Q
N
T
------
D
R
I
-
G
T
A
Y
Y
I
A
P
E
V
L
-----
R
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
------
Y
---
G
-
K
--
N
-----
E
Y
-------
D
I
L
K
R
V
-
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
----
Q
----
K
Y
S
SETP
T
I
S
D
L
-
P
---
S
L
E
S
A
M
T
N
--------
I
R
Q
F
Q
A
E
K
K
L
A
-------
Q
A
A
L
L
Y
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
58.51
42%
-124
- C2 -
-
4FG9
1
KCC1A_HUMAN
B:
[18-313]
------------
D
I
Y
D
F
R
D
V
-
L
-
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
---------------------------------------------
E
I
A
V
-
L
H
K
I
-
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
--
G
G
H
L
-----
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
--
G
----
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
-
D
-
S
-
K
-
I
M
I
S
D
F
-------------
V
L
S
--
T
A
C
-
G
T
P
G
Y
V
A
P
E
V
L
-----
A
------
Q
---
K
P
Y
-
S
K
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
---
D
-
E
--
N
-----
D
A
-------
K
L
F
E
Q
I
-
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
----
A
----
G
D
T
----
A
L
D
K
N
-
I
---
H
-
Q
S
V
S
E
Q
--------
I
K
K
N
F
A
K
S
K
W
K
-------
Q
A
F
N
A
T
A
---
V
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
58.19
40%
-114
- C2 -
-
3IGO
8
?
A:
[20-335]
----------
F
A
E
R
Y
N
I
V
C
M
-
L
-
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
A
---
S
-
A
--
K
------
N
K
-----
T
---------
S
---
T
I
L
----
R
E
V
E
L
-
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
--
S
S
S
F
-----
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
--
K
----
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
-
D
-
C
-
D
-
I
K
I
I
D
F
G
L
S
--
T
C
F
Q
Q
N
T
-----------
T
A
Y
Y
I
A
P
E
V
L
-----
R
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
------
Y
---
G
-
K
--
N
-----
E
Y
-------
D
I
L
K
R
V
-
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
----
Q
----
K
Y
S
SETP
T
I
S
D
L
-
P
---
S
L
E
S
A
M
T
N
--------
I
R
Q
F
Q
A
E
K
K
L
A
-------
Q
A
A
L
L
Y
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
58.16
49%
-30
- C2 -
-
3MFU
1
CSKP_HUMAN
A:
[22-320]
----------
F
E
D
V
Y
E
L
C
E
V
-
I
-
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
-
F
--
T
------
S
S
PGL-
S
T
---------
E
---
D
L
K
----
R
E
A
S
I
-
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
-----
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--
A
DAGF
V
-
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
E
-
N
-
S
-
A
-
P
-
V
K
L
G
D
F
G
V
A
--
I
Q
L
G
E
S
G
L
V
A
G
--
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
-----
K
------
R
---
E
P
Y
-
G
K
P
-
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
---
G
-
T
--------
K
E
-------
R
L
F
E
G
I
-
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
----
K
----
E
R
D
----
R
Y
A
Y
K
-
I
---
H
L
P
E
T
V
E
Q
--------
L
R
K
F
N
A
R
R
K
L
K
-------
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
155
Blastp_CBE
58.14
36%
-78
- C2 -
-
4YSJ
1
?
A:
[28-396]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
--
I
S
K
R
-------------------------------------
L
L
----
K
E
V
E
L
-
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
N
K
R
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
S
T
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
F
-------
D
I
L
K
K
V
-
E
K
G
K
F
T
F
D
L
P
Q
W
K
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
S
A
R
D
A
L
E
H
E
W
L
----
K
----
T
T
---------
S
-
I
DVP
S
L
E
S
T
I
L
N
--------
I
R
Q
F
Q
G
T
Q
K
L
A
-------
A
A
A
L
L
Y
M
GSK
L
T
-
T
N
E
E
T
V
E
LNKIF
Q
R
-
M
D
K
N
G
D
G
Q
L
D
K
Q
E
L
M
E
G
Y
V
E
LMKLK
G
E
D
V
S
A
L
D
Q
S
A
I
E
F
E
V
E
Q
V
L
D
A
V
D
------------------------------------------------------------------------------------------------------------------------------------------
597
HHSearch
58.09
49%
-37
- C2 -
-
3C0I
1
CSKP_HUMAN
A:
[20-317]
-------
V
-
L
F
E
D
V
Y
E
L
C
E
V
-
I
-
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
-
F
--
T
SSP---
G
L
----
S
T
---------
E
---
D
L
K
----
R
E
A
S
I
-
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
-----
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--
A
DAGF
V
-
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
-
S
-
A
-
P
-
V
K
L
G
G
F
G
V
A
--
I
Q
L
G
E
S
G
L
V
A
G
--
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
-----
K
------
R
---
E
P
Y
-
G
K
P
-
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
---
G
-
T
--
K
-----
E
--------
R
L
F
E
G
I
-
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
----
K
----
E
R
D
----
R
Y
A
Y
K
-
I
---
H
L
P
E
T
V
E
Q
--------
L
R
K
F
N
A
R
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
58.04
49%
-29
- C2 -
-
3MFR
1
CSKP_HUMAN
A:
[22-320]
----------
F
E
D
V
Y
E
L
C
E
V
-
I
-
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
-
F
--
T
------
S
S
PGL-
S
T
---------
E
---
D
L
K
----
R
E
A
S
I
-
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
-----
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--
A
DAGF
V
-
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
E
-
N
-
S
-
A
-
P
-
V
K
L
G
D
F
G
V
A
--
I
Q
L
G
E
S
G
L
V
A
G
--
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
-----
K
------
R
---
E
P
Y
-
G
K
P
-
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
---
G
-
T
--------
K
E
-------
R
L
F
E
G
I
-
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
----
K
----
E
R
D
----
R
Y
A
Y
K
-
I
---
H
L
P
E
T
V
E
Q
--------
L
R
K
F
N
A
R
R
K
L
K
-------
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
596
HHSearch
57.99
49%
-32
- C2 -
-
3C0G
1
CSKP_HUMAN
B:
[20-325]
-------
V
-
L
F
E
D
V
Y
E
L
C
E
V
-
I
-
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
-
F
--
T
SSP---
G
L
----
S
T
---------
E
---
D
L
K
----
R
E
A
S
I
-
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
-----
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--
A
DAGF
V
-
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
-
S
-
A
-
P
-
V
K
L
G
G
F
G
V
A
--
I
Q
L
G
E
S
G
L
V
A
G
--
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
-----
K
------
R
---
E
P
Y
-
G
K
P
-
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
---
G
-
T
--
K
-----
E
--------
R
L
F
E
G
I
-
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
----
K
----
E
R
D
----
R
Y
A
Y
K
-
I
---
H
L
P
E
T
V
E
Q
--------
L
R
K
F
N
A
R
R
K
L
K
-------
G
A
V
L
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
57.96
42%
-139
- C2 -
-
4FG8
1
KCC1A_HUMAN
A:
[18-299]
------------
D
I
Y
D
F
R
D
V
-
L
-
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
---------------------------------------
E
----
N
E
I
A
V
-
L
H
K
I
-
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
--
G
G
H
L
-----
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
--
G
----
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
-
D
-
S
-
K
-
I
M
I
S
D
F
-----------------------
T
P
G
Y
V
A
P
E
V
L
-----
A
------
Q
---
K
P
Y
-
S
K
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
---
D
-
E
--
N
-----
D
A
-------
K
L
F
E
Q
I
-
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
----
A
----
G
D
T
----
A
L
D
K
N
-
I
---
H
-
Q
S
V
S
E
Q
--------
I
K
K
N
F
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
57.77
36%
-78
- C2 -
-
4YSJ
1
?
B:
[28-396]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
--
I
S
K
R
-------------------------------------
L
L
----
K
E
V
E
L
-
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
N
K
R
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
S
T
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
F
-------
D
I
L
K
K
V
-
E
K
G
K
F
T
F
D
L
P
Q
W
K
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
S
A
R
D
A
L
E
H
E
W
L
----
K
----
T
T
D
----
A
--
D
S
-
I
DVP
S
L
E
S
T
I
L
N
--------
I
R
Q
F
Q
G
T
Q
K
L
A
-------
A
A
A
L
L
Y
M
GSK
L
T
-
T
N
E
E
T
V
E
LNKIF
Q
R
-
M
D
K
N
G
D
G
Q
L
D
K
Q
E
L
M
E
G
Y
V
E
LMKLK
G
E
D
V
S
A
L
D
Q
S
A
I
E
F
E
V
E
Q
V
L
D
A
V
D
------------------------------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
57.74
48%
-32
- C2 -
-
3C0H
1
CSKP_HUMAN
A:
[22-318]
----------
F
E
D
V
Y
E
L
C
E
V
-
I
-
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
-
F
--
T
------
S
S
PGL-
S
T
---------
E
---
D
L
K
----
R
E
A
S
I
-
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
-----
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--
A
DAGF
V
-
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
-
S
-
A
-
P
-
V
K
L
G
G
F
G
V
A
--
I
Q
L
G
E
S
G
L
V
A
G
--
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
-----
K
------
R
---
E
P
Y
-
G
K
P
-
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
---
G
-
T
--
K
-----
E
--------
R
L
F
E
G
I
-
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
----
K
----
E
R
D
----
R
Y
A
Y
K
-
I
---
H
L
P
E
T
V
E
Q
--------
L
R
K
F
N
A
R
R
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
57.38
42%
-123
- C2 -
-
4FG9
1
KCC1A_HUMAN
A:
[18-313]
------------
D
I
Y
D
F
R
D
V
-
L
-
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
--
I
A
K
E
--------------------------------------
E
----
N
E
I
A
V
-
L
H
K
I
-
K
-
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
--
G
G
H
L
-----
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
--
G
----
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
-
D
-
S
-
K
-
I
M
I
S
D
F
------------------------
P
G
Y
V
A
P
E
V
L
-----
A
------
Q
---
K
P
Y
-
S
K
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
---
D
-
E
--
N
-----
D
A
-------
K
L
F
E
Q
I
-
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
----
A
----
G
D
T
----
A
L
D
K
N
-
I
---
H
-
Q
S
V
S
E
Q
--------
I
K
K
N
F
A
K
S
K
W
K
-------
Q
A
F
N
A
T
A
---
V
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
57.38
49%
-28
- C2 -
-
3MFS
1
CSKP_HUMAN
A:
[22-320]
----------
F
E
D
V
Y
E
L
C
E
V
-
I
-
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
-
F
--
T
------
S
S
PGL-
S
T
---------
E
---
D
L
K
----
R
E
A
S
I
-
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
-----
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--
A
DAGF
V
-
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
E
-
N
-
S
-
A
-
P
-
V
K
L
G
D
F
G
V
A
--
I
Q
L
G
E
S
G
L
V
A
G
--
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
-----
K
------
R
---
E
P
Y
-
G
K
P
-
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
---
G
-
T
--------
K
E
-------
R
L
F
E
G
I
-
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
----
K
----
E
R
D
----
R
Y
A
Y
K
-
I
---
H
L
P
E
T
V
E
Q
--------
L
R
K
F
N
A
R
R
K
L
K
-------
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
57.32
48%
-35
- C2 -
-
3C0I
1
CSKP_HUMAN
A:
[22-317]
----------
F
E
D
V
Y
E
L
C
E
V
-
I
-
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
-
F
--
T
------
S
S
PGL-
S
T
---------
E
---
D
L
K
----
R
E
A
S
I
-
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
-----
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--
A
DAGF
V
-
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
-
S
-
A
-
P
-
V
K
L
G
G
F
G
V
A
--
I
Q
L
G
E
S
G
L
V
A
G
--
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
-----
K
------
R
---
E
P
Y
-
G
K
P
-
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
---
G
-
T
--
K
-----
E
--------
R
L
F
E
G
I
-
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
----
K
----
E
R
D
----
R
Y
A
Y
K
-
I
---
H
L
P
E
T
V
E
Q
--------
L
R
K
F
N
A
R
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
57.27
48%
-36
- C2 -
-
3C0H
1
CSKP_HUMAN
B:
[22-318]
----------
F
E
D
V
Y
E
L
C
E
V
-
I
-
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
-
F
--
T
------
S
S
PGL-
S
T
---------
E
---
D
L
K
----
R
E
A
S
I
-
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
-----
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--
A
DAGF
V
-
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
-
S
-
A
-
P
-
V
K
L
G
G
F
G
V
A
--
I
Q
L
G
E
S
G
L
V
A
G
--
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
-----
K
------
R
---
E
P
Y
-
G
K
P
-
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
---
G
-
T
--
K
-----
E
--------
R
L
F
E
G
I
-
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
----
K
----
E
R
D
----
R
Y
A
Y
K
-
I
---
H
L
P
E
T
V
E
Q
--------
L
R
K
F
N
A
R
R
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Blastp_CBE
57.05
43%
-112
- C2 -
-
2WEI
1
?
A:
[20-285]
----------
F
A
E
R
Y
N
I
V
C
M
-
L
-
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
--
I
N
K
A
---
S
-
A
--
K
------
N
K
----
D
T
---------
S
---
T
I
L
----
R
E
V
E
L
-
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
F
E
I
L
E
D
--
S
S
S
F
-----
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
--
K
----
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
-
D
-
C
-
D
-
I
K
I
I
D
F
G
L
S
--
T
C
F
Q
Q
N
T
K
M
K
---
D
R
I
-
G
T
A
Y
Y
I
A
P
E
V
L
-----
R
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
------
Y
---
G
-
K
--
N
-----
E
Y
-------
D
I
L
K
R
V
-
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
----
Q
----
K
Y
S
----
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
57.01
36%
-74
- C2 -
-
4YUQ
1
?
A:
[28-396]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
--
I
S
K
R
---
Q
--------------------------------
L
L
L
----
K
E
V
E
L
-
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
N
K
R
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
S
T
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
F
-------
D
I
L
K
K
V
-
E
K
G
K
F
T
F
D
L
P
Q
W
K
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
S
A
R
D
A
L
E
H
E
W
L
----
K
----
T
T
D
-------
D
S
-
I
DVP
S
L
E
S
T
I
L
N
--------
I
R
Q
F
Q
G
T
Q
K
L
A
-------
A
A
A
L
L
Y
M
GSK
L
T
-
T
N
E
E
T
V
E
LNKIF
Q
R
-
M
D
K
N
G
D
G
Q
L
D
K
Q
E
L
M
E
G
Y
V
E
LMKLK
G
E
D
V
S
A
L
D
Q
S
A
I
E
F
E
V
E
Q
V
L
D
A
V
D
------------------------------------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
56.95
36%
-75
- C2 -
-
4YUQ
1
?
B:
[28-396]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
--
I
S
K
R
---
Q
---------------------------------
L
L
----
K
E
V
E
L
-
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
N
K
R
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
S
T
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
F
-------
D
I
L
K
K
V
-
E
K
G
K
F
T
F
D
L
P
Q
W
K
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
S
A
R
D
A
L
E
H
E
W
L
----
K
----
T
T
D
-------
D
S
-
I
DVP
S
L
E
S
T
I
L
N
--------
I
R
Q
F
Q
G
T
Q
K
L
A
-------
A
A
A
L
L
Y
M
GSK
L
T
-
T
N
E
E
T
V
E
LNKIF
Q
R
-
M
D
K
N
G
D
G
Q
L
D
K
Q
E
L
M
E
G
Y
V
E
LMKLK
G
E
D
V
S
A
L
D
Q
S
A
I
E
F
E
V
E
Q
V
L
D
A
V
D
------------------------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
56.94
48%
-31
- C2 -
-
3C0G
1
CSKP_HUMAN
B:
[22-326]
----------
F
E
D
V
Y
E
L
C
E
V
-
I
-
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
--
V
D
V
A
---
K
-
F
--
T
------
S
S
PGL-
S
T
---------
E
---
D
L
K
----
R
E
A
S
I
-
C
H
M
L
-
K
-
H
-
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
-----
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--
A
DAGF
V
-
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
-
S
-
A
-
P
-
V
K
L
G
G
F
G
V
A
--
I
Q
L
G
E
S
G
L
V
A
G
--
G
R
V
-
G
T
P
H
F
M
A
P
E
V
V
-----
K
------
R
---
E
P
Y
-
G
K
P
-
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
---
G
-
T
--
K
-----
E
--------
R
L
F
E
G
I
-
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
----
K
----
E
R
D
----
R
Y
A
Y
K
-
I
---
H
L
P
E
T
V
E
Q
--------
L
R
K
F
N
A
R
R
K
L
K
-------
G
A
V
L
A
A
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
Blastp_CBE
56.21
38%
-22
- C2 -
-
4M84
1
?
A:
[24-365]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
---
K
E
Q
I
S
V
D
V
--------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
-----
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
55.97
33%
-139
- C2 -
-
4BFM
1
MELK_MOUSE
A:
[11-265]
--------------
Y
E
L
Y
E
T
-
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
---
A
-
L
--
G
------
S
-----
D
L
---------
P
---
R
V
K
----
T
E
I
D
A
-
L
K
S
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
--
K
N
K
I
-----
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
--
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
N
H
-
K
-------
L
K
L
I
D
F
G
L
C
--
A
K
-------------
C
-
G
S
L
A
Y
A
A
P
E
L
I
-----
Q
--------------
G
S
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
---
D
-
D
--
N
-----
V
M
-------
A
L
Y
K
K
I
-
M
R
G
K
Y
E
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
R
N
L
L
N
H
P
W
V
----
M
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
55.55
42%
-88
- C2 -
-
5JZN
1
B:
[17-278]
----------
I
T
E
R
Y
K
V
G
R
T
-
I
-
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
--
I
K
K
S
---
K
-
C
--
R
------
G
K
----
E
H
---------
M
----
I
Q
----
N
E
V
S
I
-
L
R
R
V
-
K
-
H
-
P
N
I
V
L
L
I
E
E
M
D
V
--
P
T
E
L
-----
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
S
T
--
N
----
K
-
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
Q
-
D
-
G
-
S
K
S
-
L
K
L
G
D
F
G
L
A
--
T
I
V
D
G
---
P
L
Y
--
T
V
C
-
G
T
P
T
Y
V
A
P
E
I
I
-----
A
------
E
---
T
G
Y
-
G
L
K
-
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
RG----
S
--------------
Q
E
-------
V
L
F
D
Q
I
-
L
M
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
V
Q
V
L
E
H
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Blastp_CBE
55.55
38%
-26
- C2 -
-
3UPX
1
?
A:
[24-378]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
---
K
------
V
--------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
-----
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
55.47
42%
-86
- C2 -
-
5JZN
1
DCLK1_HUMAN
A:
[17-278]
----------
I
T
E
R
Y
K
V
G
R
T
-
I
-
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
--
I
K
K
S
---
K
-
C
--
R
------
G
K
----
E
H
---------
M
----
I
Q
----
N
E
V
S
I
-
L
R
R
V
-
K
-
H
-
P
N
I
V
L
L
I
E
E
M
D
V
--
P
T
E
L
-----
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
S
T
--
N
----
K
-
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
Q
-
D
-
G
-
S
K
S
-
L
K
L
G
D
F
G
L
A
--
T
I
V
D
G
---
P
L
Y
--
T
V
C
-
G
T
P
T
Y
V
A
P
E
I
I
-----
A
------
E
---
T
G
Y
-
G
L
K
-
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
RG----
S
--------
D
-----
Q
E
-------
V
L
F
D
Q
I
-
L
M
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
V
Q
V
L
E
H
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
55.44
38%
-26
- C2 -
-
4ONA
1
?
A:
[24-365]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
---
K
E
Q
I
S
V
D
V
--------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
-----
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
55.43
33%
-137
- C2 -
-
4CQG
1
MELK_MOUSE
A:
[11-265]
--------------
Y
E
L
Y
E
T
-
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
---
A
-
L
--
G
------
S
-----
D
L
---------
P
---
R
V
K
----
T
E
I
D
A
-
L
K
S
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
--
K
N
K
I
-----
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
--
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
N
H
-
K
-------
L
K
L
I
D
F
G
L
C
--
A
K
-------------
C
-
G
S
L
A
Y
A
A
P
E
L
I
-----
Q
--------------
G
S
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
---
D
-
D
--
N
-----
V
M
-------
A
L
Y
K
K
I
-
M
R
G
K
Y
E
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
R
N
L
L
N
H
P
W
V
----
M
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
55.38
38%
-22
- C2 -
-
6BFA
1
?
A:
[24-365]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
---
K
E
Q
I
S
V
D
V
--------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
-----
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
55.26
34%
-143
- C2 -
-
4BL1
1
MELK_HUMAN
A:
[12-266]
--------------
Y
E
L
H
E
T
-
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
---
T
-
L
----------------
L
---------
P
---
R
I
K
----
T
E
I
E
A
-
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
--
A
N
K
I
-----
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
--
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
-
K
-------
L
K
L
I
D
F
G
L
C
--
A
K
----------------
S
L
A
Y
A
A
P
E
L
I
-----
Q
------
G
---
K
---
G
S
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
---
D
-
D
--
N
-----
V
M
-------
A
L
Y
K
K
I
-
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
----
M
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
Blastp_CBE
55.11
38%
-24
- C2 -
-
5W9R
1
?
A:
[24-379]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
---
K
-----
D
V
--------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
-----
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
55.02
42%
-91
- C2 -
-
5JZJ
2
DCLK1_HUMAN
A:
[34-295]
----------
I
T
E
R
Y
K
V
G
R
T
-
I
-
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
--
I
K
K
S
---
K
-
C
--
R
------
G
K
----
E
H
---------
M
----
I
Q
----
N
E
V
S
I
-
L
R
R
V
-
K
-
H
-
P
N
I
V
L
L
I
E
E
M
D
V
--
P
T
E
L
-----
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
S
T
--
N
----
K
-
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
Q
-
D
-
G
-
S
K
S
-
L
K
L
G
D
F
G
L
A
--
T
I
V
D
G
---
P
L
Y
--
T
V
C
-
G
T
P
T
Y
V
A
P
E
I
I
-----
A
------
E
---
T
G
Y
-
G
L
K
-
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
RG----
S
---------------
E
-------
V
L
F
D
Q
I
-
L
M
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
V
Q
V
L
E
H
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
Blastp_CBE
55.01
38%
-23
- C2 -
-
4WG5
1
?
A:
[24-365]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
---
K
E
Q
I
S
V
D
V
--------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
-----
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
54.90
38%
-25
- C2 -
-
4WG3
1
?
A:
[24-365]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
---
K
-----
D
V
--------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
-----
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
54.73
34%
-152
- C2 -
-
4BKZ
1
MELK_HUMAN
A:
[12-266]
--------------
Y
E
L
H
E
T
-
I
-
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
---
T
-
L
----------------
L
---------
P
---
R
I
K
----
T
E
I
E
A
-
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
--
A
N
K
I
-----
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
--
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
-
K
-------
L
K
L
I
D
F
G
L
C
--
A
-----------------
S
L
A
Y
A
A
P
E
L
I
-----
Q
------
G
-------
G
S
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
---
D
-
D
--
N
-----
V
M
-------
A
L
Y
K
K
I
-
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
----
M
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
54.71
38%
-18
- C2 -
-
3I7B
4
?
A:
[24-368]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
---
K
E
Q
I
S
V
D
V
--------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
-----
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
100
Blastp_CBE
54.71
38%
-23
- C2 -
-
5W8R
1
?
A:
[24-371]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
---
K
E
Q
--
V
D
V
--------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
-----
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
602
HHSearch
54.70
44%
-92
- C2 -
-
2W4O
1
KCC4_HUMAN
A:
[50-344]
---------
A
L
S
D
F
F
E
V
E
S
E
-
L
-
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
--
L
K
K
----------------------------------------------
I
G
V
-
L
L
R
L
-
S
-
H
-
P
N
I
I
K
L
K
E
I
F
E
T
--
P
T
E
I
-----
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
--
G
----
Y
-
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
A
-
P
-
D
-
A
-
P
-
L
K
I
A
D
F
----------------------
G
T
P
G
Y
C
A
P
E
I
L
-----
R
------
G
---
C
A
Y
-
G
P
E
-
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
------
Y
---
D
-
E
--
R
-----
G
D
Q------
F
M
F
R
R
I
-
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
----
T
----
G
K
A
----
A
--
N
F
-
V
---
H
M
D
T
A
Q
K
K
--------
L
Q
E
F
N
A
R
R
K
L
K
-------
A
A
V
K
A
V
V
---
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
54.33
38%
-21
- C2 -
-
5DVR
1
?
A:
[65-523]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
------
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
-
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
---------------------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
-----
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
54.27
38%
-24
- C2 -
-
5JN2
1
?
A:
[65-415]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
---
K
------
V
--------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
-----
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
101
Blastp_CBE
54.16
38%
-22
- C2 -
-
5W80
1
?
A:
[24-372]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
---
K
----
V
D
V
--------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
-----
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
53.95
38%
-23
- C2 -
-
4IHP
1
?
A:
[47-396]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
---
K
E
Q
I
S
--
V
--------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
-----
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
341
Blastp_CBE
53.93
38%
-116
- C2 -
-
5ES1
1
MARK4_HUMAN
A:
[17-268]
--------------
Y
R
L
L
R
T
-
I
-
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
--
I
D
K
T
---
Q
-
L
--
N
------
P
S
----
S
L
---------
Q
---
K
L
F
----
R
E
V
R
I
-
M
K
G
L
-
N
-
H
-
P
N
I
V
K
L
F
E
V
I
E
T
--
E
K
T
L
-----
Y
L
V
M
E
Y
A
S
A
G
E
V
F
D
Y
L
V
S
H
--
G
----
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
K
N
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
E
------
A
-
N
-
I
K
I
A
D
F
G
F
S
--
N
-----------------
S
P
P
Y
A
A
P
E
L
F
-----
Q
------
G
---
K
K
Y
-
D
G
P
E
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
------
D
---
G
-
H
--
N
-----
L
K
-------
E
L
R
E
R
V
-
L
R
G
K
Y
R
V
P
F
----
Y
M
S
T
D
C
E
S
I
L
R
R
F
L
V
L
N
P
A
K
R
C
T
L
E
Q
I
M
K
D
K
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
53.84
46%
-104
- C2 -
-
2JAM
3
KCC1G_HUMAN
A:
[6-265]
---------
N
I
R
K
T
F
I
F
M
E
V
-
L
-
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
--
I
--
K
---
K
----------------------------
S
---
S
L
E
----
N
E
I
A
V
-
L
K
K
I
-
K
-
H
-
E
N
I
V
T
L
E
D
I
Y
E
S
--
T
T
H
Y
-----
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
--
G
----
V
-
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
-
N
-
S
-
K
-
I
M
I
T
D
F
G
L
S
-----
K
M
E
Q
N
G
I
M
--
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
-----
A
------
Q
---
K
P
Y
-
S
K
A
-
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
------
Y
---
E
-
E
--
T
-----
E
S
-------
K
L
F
E
K
I
-
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
53.83
46%
-104
- C2 -
-
2JAM
3
KCC1G_HUMAN
B:
[5-265]
-------
T
-
N
I
R
K
T
F
I
F
M
E
V
-
L
-
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
--
I
--
K
---
K
----------------------------
S
---
S
L
E
----
N
E
I
A
V
-
L
K
K
I
-
K
-
H
-
E
N
I
V
T
L
E
D
I
Y
E
S
--
T
T
H
Y
-----
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
--
G
----
V
-
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
-
N
-
S
-
K
-
I
M
I
T
D
F
G
L
S
-----
K
M
E
Q
N
G
I
M
--
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
-----
A
------
Q
---
K
P
Y
-
S
K
A
-
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
------
Y
---
E
-
E
--
T
-----
E
S
-------
K
L
F
E
K
I
-
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
53.75
38%
-28
- C2 -
-
4TZR
1
?
A:
[24-365]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
---
K
-----
D
V
--------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
-----
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
53.74
38%
-24
- C2 -
-
5JMS
2
?
A:
[65-417]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
---
K
------
V
--------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
-----
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
53.64
38%
-27
- C2 -
-
5T6A
1
?
A:
[65-427]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
-
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
---
K
---------------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
-------
G
D
G
Q
L
-
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
53.58
36%
-20
- C2 -
-
4YZB
1
?
B:
[28-396]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
--
I
S
K
R
---------------
Q
K
T---
D
K
---------
E
---
L
L
L
----
K
E
V
E
L
-
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
N
K
R
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
S
T
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
F
-------
D
I
L
K
K
V
-
E
K
G
K
F
T
F
D
L
P
Q
W
K
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
S
A
R
D
A
L
E
H
E
W
L
----
K
----
T
----------
S
-
I
DVP
S
L
E
S
T
I
L
N
--------
I
R
Q
F
Q
G
T
Q
K
L
A
-------
A
A
A
L
L
Y
M
GSK
L
T
-
T
N
E
E
T
V
E
LNKIF
Q
R
-
M
D
K
N
G
D
G
Q
L
D
K
Q
E
L
M
E
G
Y
V
E
LMKLK
G
E
D
V
S
A
L
D
Q
S
A
I
E
F
E
V
E
Q
V
L
D
A
V
D
------------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
53.57
42%
-75
- C2 -
-
5JZJ
1
B:
[34-295]
----------
I
T
E
R
Y
K
V
G
R
T
-
I
-
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
--
I
K
K
S
---
K
-
C
--
R
------
G
K
----
E
H
---------
M
----
I
Q
----
N
E
V
S
I
-
L
R
R
V
-
K
-
H
-
P
N
I
V
L
L
I
E
E
M
D
V
--
P
T
E
L
-----
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
S
T
--
N
----
K
-
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
E
H
Q
-
D
-
G
-
S
K
S
-
L
K
L
G
D
F
G
L
A
--
T
I
V
D
G
---
P
L
Y
--
T
V
C
-
G
T
P
T
Y
V
A
P
E
I
I
-----
A
------
E
---
T
G
Y
-
G
L
K
-
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R---------------------
E
-------
V
L
F
D
Q
I
-
L
M
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
V
Q
V
L
E
H
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
53.54
38%
-22
- C2 -
-
4WG4
1
?
A:
[24-371]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
---
K
-----
D
V
--------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
-----
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
111
Blastp_CBE
53.49
38%
-21
- C2 -
-
3V5P
1
?
A:
[24-374]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
---
K
------
V
--------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
-----
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
53.26
34%
-116
* C2 *
-
5TVT
1
MELK_HUMAN
A:
[12-266]
--------------
Y
E
L
H
E
T
-
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
---
T
-
L
--
G
------
S
-----
D
L
---------
P
---
R
I
K
----
T
E
I
E
A
-
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
--
A
N
K
I
-----
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
--
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
-
K
-------
L
K
L
I
D
F
G
L
C
--
A
K
---------------
G
S
L
A
Y
A
A
P
E
L
I
-----
Q
------
G
---
K
S
Y
L
G
S
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
---
D
-
D
--
N
-----
V
M
-------
A
L
Y
K
K
I
-
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
----
M
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
Blastp_CBE
53.26
38%
-26
- C2 -
-
4IEB
1
?
A:
[47-389]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
-----------T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
M
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
-
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
---
K
E
Q
I
S
V
D
V
--------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
-----
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
53.25
34%
-116
- C2 -
-
5MAH
2
MELK_HUMAN
A:
[12-266]
--------------
Y
E
L
H
E
T
-
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
---
T
-
L
--
G
------
S
-----
D
L
---------
P
---
R
I
K
----
T
E
I
E
A
-
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
--
A
N
K
I
-----
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
--
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
-
K
-------
L
K
L
I
D
F
G
L
C
--
A
K
----------------
S
L
A
Y
A
A
P
E
L
I
-----
Q
------
G
---
K
--L
G
S
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
---
D
-
D
--
N
-----
V
M
-------
A
L
Y
K
K
I
-
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
----
M
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
Blastp_CBE
53.15
38%
-22
- C2 -
-
5W91
1
?
A:
[24-372]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
---
K
------
V
--------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
------
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
53.04
38%
-104
- C2 -
-
3F3Z
5
?
A:
[11-265]
--------------
Y
T
L
E
N
T
-
I
-
G
R
G
S
W
G
E
V
K
I
A
V
Q
K
G
T
R
I
R
R
A
A
K
K
--
I
--
P
---
K
-
Y
--
F
------
V
E
----
D
V
---------
D
---
R
F
K
----
Q
E
I
E
I
-
M
K
S
L
-
D
-
H
-
P
N
I
I
R
L
Y
E
T
F
E
D
--
N
T
D
I
-----
Y
L
V
M
E
L
C
T
G
G
E
L
F
E
R
V
V
H
K
--
R
----
V
-
F
R
E
S
D
A
A
R
I
M
K
D
V
L
S
A
V
A
Y
C
H
K
L
N
V
A
H
R
D
L
K
P
E
N
F
L
F
L
T
D
S
-
P
-
D
-
S
-
P
-
L
K
L
I
D
F
G
L
A
--
A
R
F
K
P
G
K
M
M
R
T
--
K
-
V
-
G
T
P
Y
Y
V
S
P
Q
V
L
------------
E
---
G
L
Y
-
G
P
E
-
C
D
E
W
S
A
G
V
M
M
Y
V
L
L
C
G
Y
P
P
F
----------
S
-
A
--
P
-----
T
D
-------
E
V
M
L
K
I
-
R
E
G
T
F
T
F
P
E
K
D
W
L
N
V
S
P
Q
A
E
S
L
I
R
R
L
L
T
K
S
P
K
Q
R
I
T
S
L
Q
A
L
E
H
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
52.94
38%
-24
- C2 -
-
4IH8
1
?
A:
[47-409]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
--
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
----------
V
--------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
-----
N
G
D
G
Q
L
D
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
52.85
36%
-18
- C2 -
-
4YZB
1
?
A:
[28-396]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
--
I
S
K
R
---------------
Q
K
T---
D
K
---------
E
---
L
L
L
----
K
E
V
E
L
-
L
K
K
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
N
K
R
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
S
T
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
F
-------
D
I
L
K
K
V
-
E
K
G
K
F
T
F
D
L
P
Q
W
K
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
S
A
R
D
A
L
E
H
E
W
L
----
K
----
T
--------
T
D
S
-
I
DVP
S
L
E
S
T
I
L
N
--------
I
R
Q
F
Q
G
T
Q
K
L
A
-------
A
A
A
L
L
Y
M
GSK
L
T
-
T
N
E
E
T
V
E
LNKIF
Q
R
-
M
D
K
N
G
D
G
Q
L
D
K
Q
E
L
M
E
G
Y
V
E
LMKLK
G
E
D
V
S
A
L
D
Q
S
A
I
E
F
E
V
E
Q
V
L
D
A
V
D
------------------------------------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
52.80
34%
-111
- C2 -
-
5TWL
1
MELK_HUMAN
A:
[12-266]
--------------
Y
E
L
H
E
T
-
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
---
T
-
L
--
G
------
S
-----
D
L
---------
P
---
R
I
K
----
T
E
I
E
A
-
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
--
A
N
K
I
-----
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
--
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
-
K
-------
L
K
L
I
D
F
G
L
------------------
C
-
G
S
L
A
Y
A
A
P
E
L
I
-----
Q
------
G
---
K
S
Y
L
G
S
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
---
D
-
D
--
N
-----
V
M
-------
A
L
Y
K
K
I
-
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
----
M
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
52.78
38%
-100
- C2 -
-
5EAK
1
MARK2_HUMAN
B:
[17-268]
--------------
Y
R
L
L
K
T
-
I
-
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
--
I
D
K
T
---
Q
-
L
--
N
------
S
S
----
S
L
---------
Q
---
K
L
F
----
R
E
V
R
I
-
M
K
V
L
-
N
-
H
-
P
N
I
V
K
L
F
E
V
I
E
T
--
E
K
T
L
-----
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
--
G
----
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
-
N
-------
I
K
I
A
D
F
G
------------------
F
C
-
G
S
P
P
Y
A
A
P
E
L
F
-----
Q
------
G
---
K
K
Y
-
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
------
D
---
G
-
Q
--
N
-----
L
K
-------
E
L
R
E
R
V
-
L
R
G
K
Y
R
I
P
F
----
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
52.38
38%
-28
- C2 -
-
5T6K
1
?
A:
[65-425]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
-
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
---------------------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
Q
D
E
T
K
E
L
T
A
I
F
H
K
M
D
K
-----
N
G
---
L
D
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
52.36
39%
-92
- C2 -
-
2CN5
1
CHK2_HUMAN
A:
[16-284]
------------
D
E
Y
I
M
S
K
T
-
L
-
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
R
------------------------------------
N
V
E
----
T
E
I
E
I
-
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
D
Y
------
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
-
D
-
C
-
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
T
S
L
M
R
--
T
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
---
E
H
R
--
T
-----
Q
V
-------
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
52.26
34%
-118
- C2 -
-
5M5A
1
MELK_HUMAN
A:
[12-266]
--------------
Y
E
L
H
E
T
-
I
-
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
--
M
D
K
N
---
T
-
L
--
G
------
S
-----
D
L
---------
P
---
R
I
K
----
T
E
I
E
A
-
L
K
N
L
-
R
-
H
-
Q
H
I
C
Q
L
Y
H
V
L
E
T
--
A
N
K
I
-----
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
--
D
----
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
-
K
-------
L
K
L
I
D
F
G
L
C
--
A
-----------------
S
L
A
Y
A
A
P
E
L
I
-----
Q
------
G
---
K
--L
G
S
E
-
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
---
D
-
D
--
N
-----
V
M
-------
A
L
Y
K
K
I
-
M
R
G
K
Y
D
V
--
P
K
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
----
M
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
52.25
38%
-108
- C2 -
-
5KZ7
1
MARK2_HUMAN
A:
[35-286]
--------------
Y
R
L
L
K
T
-
I
-
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
--
I
D
K
T
---
Q
-
L
--
N
------
S
S
----
S
L
---------
Q
---
K
L
F
----
R
E
V
R
I
-
M
K
V
L
-
N
-
H
-
P
N
I
V
K
L
F
E
V
I
E
T
--
E
K
T
L
-----
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
--
G
----
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
-
N
-------
I
K
I
A
D
F
----------------------
G
S
P
P
Y
A
A
P
E
L
F
-----
Q
------
G
---
K
---
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
------
D
--------
N
-----
L
K
-------
E
L
R
E
R
V
-
L
R
G
K
Y
R
I
P
F
----
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
52.19
38%
-103
- C2 -
-
5KZ8
1
MARK2_HUMAN
A:
[35-286]
--------------
Y
R
L
L
K
T
-
I
-
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
--
I
D
K
T
---
Q
-
L
--
N
------
S
S
----
S
L
---------
Q
---
K
L
F
----
R
E
V
R
I
-
M
K
V
L
-
N
-
H
-
P
N
I
V
K
L
F
E
V
I
E
T
--
E
K
T
L
-----
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
--
G
----
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
-
N
-------
I
K
I
A
D
F
G
-------------------
C
-
G
S
P
P
Y
A
A
P
E
L
F
-----
Q
------
G
---
K
K
Y
-
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
------
D
---
G
-
Q
--
N
-----
L
K
-------
E
L
R
E
R
V
-
L
R
G
K
Y
R
I
P
F
----
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
52.16
38%
-101
- C2 -
-
5KZ8
1
MARK2_HUMAN
B:
[35-286]
--------------
Y
R
L
L
K
T
-
I
-
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
--
I
D
K
T
---
Q
-
L
--
N
------
S
S
----
S
L
---------
Q
---
K
L
F
----
R
E
V
R
I
-
M
K
V
L
-
N
-
H
-
P
N
I
V
K
L
F
E
V
I
E
T
--
E
K
T
L
-----
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
--
G
----
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
-
N
-------
I
K
I
A
D
F
----------------------
G
S
P
P
Y
A
A
P
E
L
F
-----
Q
------
G
---
K
K
Y
-
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
------
D
---
G
-
Q
--
N
-----
L
K
-------
E
L
R
E
R
V
-
L
R
G
K
Y
R
I
P
F
----
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
52.11
38%
-108
- C2 -
-
5KZ7
1
MARK2_HUMAN
B:
[35-286]
--------------
Y
R
L
L
K
T
-
I
-
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
--
I
D
K
T
---
Q
-
L
--
N
------
S
S
----
S
L
---------
Q
---
K
L
F
----
R
E
V
R
I
-
M
K
V
L
-
N
-
H
-
P
N
I
V
K
L
F
E
V
I
E
T
--
E
K
T
L
-----
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
--
G
----
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
-
N
-------
I
K
I
A
D
F
----------------------
G
S
P
P
Y
A
A
P
E
L
F
-----
Q
------
G
---
K
---
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
------
D
--------
N
-----
L
K
-------
E
L
R
E
R
V
-
L
R
G
K
Y
R
I
P
F
----
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
52.07
33%
-70
- C2 -
-
4JG7
1
A:
[32-328]
---------
Q
F
T
D
G
Y
E
V
K
E
D
-
I
-
G
V
--
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
--
I
D
K
S
---
K
------------
R
----
D
--------------
P
T
E
----
E
I
E
I
L
-
L
R
Y
G
-
Q
-
H
-
P
N
I
I
T
L
K
D
V
Y
D
D
--
G
K
Y
V
-----
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
--
K
----
F
-
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
-
G
-
N
P
E
-
S
-
I
R
I
C
D
F
G
F
A
--
K
Q
L
R
A
E
N
G
L
L
M
--
T
P
C
-
Y
T
A
N
F
V
A
P
E
V
L
-----
E
------
R
---
Q
G
Y
-
D
A
A
-
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
------
A
NGP
D
-
D
--
T
-----
P
E
-------
E
I
L
A
R
I
-
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
----
V
----
H
W
D
----
Q
L
P
Q
Y
-
Q
-------------------
L
N
R
Q
D
A
P
H
L
V
K
-------
G
A
M
A
A
T
Y
---
S
A
L
N
R
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
52.04
44%
-63
- C2 -
-
2W4O
1
KCC4_HUMAN
A:
[51-346]
----------
L
S
D
F
F
E
V
E
S
E
-
L
-
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
--
L
K
----------
K
------------------------------------
I
G
V
-
L
L
R
L
-
S
-
H
-
P
N
I
I
K
L
K
E
I
F
E
T
--
P
T
E
I
-----
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
--
G
----
Y
-
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
A
-
P
-
D
-
A
-
P
-
L
K
I
A
D
F
----------------------
G
T
P
G
Y
C
A
P
E
I
L
-----
R
------
G
---
C
A
Y
-
G
P
E
-
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
------
Y
---
D
-
E
RG
D
-----
Q
F
--------
M
F
R
R
I
-
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
----
T
----
G
K
A
------
A
N
F
-
V
---
H
M
D
T
A
Q
K
K
--------
L
Q
E
F
N
A
R
R
K
L
K
-------
A
A
V
K
A
V
V
---
A
S
-
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
51.74
38%
-68
- C2 -
-
2X4F
3
MYLK4_HUMAN
B:
[95-347]
------------------
E
I
-
L
-
G
G
G
--
G
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
--
I
K
T
R
---
G
-
M
----------
K
----
D
K
---------
E
---
E
V
K
----
N
E
I
S
V
-
M
N
Q
L
-
D
-
H
-
A
N
L
I
Q
L
Y
D
A
F
E
S
--
K
N
D
I
-----
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
--
S
----
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
---
A
-
K
-
Q
-
I
K
I
I
D
F
G
L
A
--
R
R
Y
K
P
R
E
K
L
K
V
--
N
F
--
G
T
P
E
F
L
A
P
E
V
V
-----
N
------
Y
---
D
F
V
-
S
F
P
-
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
------
L
---
G
-
D
--
N
-----
D
A
-------
E
T
L
N
N
I
-
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
----
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
51.71
39%
-101
- C2 -
-
4BDH
4
CHK2_HUMAN
A:
[16-284]
------------
D
E
Y
I
M
S
K
T
-
L
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
-------------------------------------
N
V
E
----
T
E
I
E
I
-
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
D
Y
------
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
-
D
-
C
-
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
T
S
L
M
R
--
T
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
---
E
H
R
--
T
-----
Q
V
-------
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
51.64
36%
-27
- C2 -
-
4QOX
1
CDPK4_PLAF7
A:
[75-404]
----------
F
N
E
Q
Y
K
G
I
K
I
-
L
-
G
K
G
S
F
G
E
V
I
L
S
R
D
K
H
T
G
H
E
Y
A
I
K
V
--
I
S
K
K
---
H
-
V
--
K
------
R
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
E
L
-
L
K
M
L
-
D
-
H
-
I
N
I
M
K
L
Y
E
F
F
E
D
--
N
N
Y
Y
-----
Y
L
V
S
D
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
Y
E
I
D
A
A
R
I
I
K
Q
I
L
S
G
I
T
Y
M
H
K
N
N
V
V
H
R
D
L
K
P
E
N
I
L
L
E
T
K
N
--E
D
-
M
-
I
-
I
K
I
I
D
F
G
L
S
--
T
H
F
E
Y
S
-------
K
I
--
G
T
A
Y
Y
I
A
P
D
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
I
W
S
C
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
S
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
A
G
K
Y
T
F
D
L
P
Q
F
K
K
I
S
D
K
A
K
D
L
I
K
K
M
L
M
Y
T
S
A
V
R
I
S
A
R
D
A
L
E
H
E
W
I
----
K
----
M
M
T
----
S
K
---------
L
E
L
S
I
A
N
--------
I
R
Q
F
Q
S
T
Q
K
L
A
QAALLYM
G
S
K
L
T
T
I
---
D
E
-
T
K
E
L
T
K
I
F----
K
K
-
M
D
K
N
G
D
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
276
Blastp_CBE
51.61
39%
-102
- C2 -
-
4BDJ
1
CHK2_HUMAN
A:
[16-284]
------------
D
E
Y
I
M
S
K
T
-
L
-
G
-----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
-------------------------------------
N
V
E
----
T
E
I
E
I
-
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
D
Y
------
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
-
D
-
C
-
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
-
E
T
S
L
M
R
--
T
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
---
E
H
R
--
T
-----
Q
V
-------
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
51.54
35%
-131
- C2 -
-
5XZV
1
RAD53_YEAST
A:
[194-465]
----------
F
K
D
F
S
I
I
D
E
V
-
V
-
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
A
V
K
I
--
I
S
K
R
---
K
-
V
--
I
------
G
-----
N
M
---------
D
---
G
V
T
----
R
E
L
E
V
-
L
Q
K
L
-
N
-
H
-
P
R
I
V
R
L
K
G
F
Y
E
D
--
T
E
S
Y
-----
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
A
H
--
G
----
A
-
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
I
-
E
Q
D
-
D
-
P
-
V
-
L
-
V
K
I
T
D
F
G
L
A
---
K
-----------------
L
A
Y
V
A
P
E
V
I
----------------
N
E
Y
-
S
S
L
-
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
------------
S
--
T
-----
Q
D
-------
Q
L
Y
K
Q
I
-
G
R
G
S
----
L
K
D
F
-
R
I
S
E
E
A
R
D
F
I
D
S
L
---
D
P
N
N
--
T
A
A
K
A
L
N
H
P
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
51.45
38%
-95
- C2 -
-
5EAK
1
MARK2_HUMAN
A:
[17-268]
--------------
Y
R
L
L
K
T
-
I
-
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
--
I
D
K
T
---
Q
-
L
--
N
------
S
S
----
S
L
---------
Q
---
K
L
F
----
R
E
V
R
I
-
M
K
V
L
-
N
-
H
-
P
N
I
V
K
L
F
E
V
I
E
T
--
E
K
T
L
-----
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
--
G
----
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
-
N
-------
I
K
I
A
D
F
G
F
S
----------------
F
C
-
G
S
P
P
Y
A
A
P
E
L
F
-----
Q
------
G
---
K
K
Y
-
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
------
D
---
G
-
Q
--
N
-----
L
K
-------
E
L
R
E
R
V
-
L
R
G
K
Y
R
I
P
F
----
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
51.21
39%
-104
- C2 -
-
4BDD
3
CHK2_HUMAN
A:
[16-284]
------------
D
E
Y
I
M
S
K
T
-
L
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
-------------------------------------
N
V
E
----
T
E
I
E
I
-
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
D
Y
------
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
-
D
-
C
-
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
T
S
L
M
R
--
T
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
---
E
H
R
--
T
-----
Q
V
-------
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
51.13
40%
-18
- C2 -
-
3HZT
9
?
A:
[3-345]
-----------
S
D
R
Y
Q
R
V
K
K
-
L
-
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
--
I
K
K
S
---
S
-
V
--
T
------
T
T
----
S
N
---------
S
G--
A
L
L
----
D
E
V
A
V
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
R
N
Y
-----
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
--
Q
----
K
-
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
R
-
D
-
A
-
L
-
I
K
I
V
D
F
G
L
S
AH
F
E
V
--------------
G
T
A
Y
Y
I
A
P
E
V
L
-----
R
------
K
----
K
Y
-
D
E
K
-
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
------
G
---
G
-
Q
--
T
-----
D
Q
-------
E
I
L
K
R
V
-
E
K
G
K
F
S
F
D
P
P
D
W
T
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
A
E
E
A
L
N
H
P
W
I
----
V
KFCS
Q
--------
V
G
K
-
H
---
A
L
T
G
A
L
G
N
--------
M
K
K
F
Q
S
S
Q
K
L
A
QAAMLFM
G
S
K
L
T
T
L
---
E
E
-
T
K
E
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
50.84
33%
-72
- C2 -
-
4MAO
1
A:
[32-327]
---------
Q
F
T
D
G
Y
E
V
K
E
D
-
I
-
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
--
I
D
K
S
---
K
------------
R
----
D
--------------
P
T
E
----
E
I
E
I
L
-
L
R
Y
G
-
Q
-
H
-
P
N
I
I
T
L
K
D
V
Y
D
D
--
G
K
Y
V
-----
Y
V
V
M
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
--
K
----
F
-
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
-
G
-
N
P
E
-
S
-
I
R
I
C
D
F
G
F
A
--
K
Q
L
R
A
E
N
G
L
L
M
--
T
P
C
-
Y
T
A
N
F
V
A
P
E
V
L
-----
E
------
R
---
Q
G
Y
-
D
A
A
-
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
------
A
NGP
D
-
D
--
T
-----
P
E
-------
E
I
L
A
R
I
-
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
----
V
----
H
W
D
----
Q
L
P
Q
Y
-
Q
-------------------
L
N
R
Q
D
A
P
H
L
V
K
-------
G
A
M
A
A
T
Y
---
S
A
L
N
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
228
Blastp_CBE
50.76
36%
-87
- C2 -
-
3ZXT
1
DAPK1_HUMAN
A:
[11-276]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
----------------
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
----------------
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
206
Blastp_CBE
50.71
33%
-69
- C2 -
-
4JG8
1
A:
[32-329]
---------
Q
F
T
D
G
Y
E
V
K
E
D
-
I
-
G
V
G
S
Y
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
--
I
D
K
S
---
K
------------
R
----
D
--------------
P
T
E
----
E
I
E
I
L
-
L
R
Y
G
-
Q
-
H
-
P
N
I
I
T
L
K
D
V
Y
D
D
--
G
K
Y
V
-----
Y
V
V
M
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
--
K
----
F
-
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
-
G
-
N
P
E
-
S
-
I
R
I
C
D
F
G
F
A
--
K
Q
L
R
A
E
N
G
L
L
M
--
T
P
C
-
Y
T
A
N
F
V
A
P
E
V
L
-----
E
------
R
---
Q
G
Y
-
D
A
A
-
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
------
A
NGP
D
-
D
--
T
-----
P
E
-------
E
I
L
A
R
I
-
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
----
V
----
H
W
D
----
Q
L
P
Q
Y
-
Q
-------------------
L
N
R
Q
D
A
P
H
L
V
K
-------
G
A
M
A
A
T
Y
---
S
A
L
N
R
N
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
50.64
38%
-28
- C2 -
-
5T6I
1
?
A:
[65-428]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
------
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
---
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
----------
V
--------
P
S
L
D
N
A
I
L
N
I
R
-------
Q
F
Q
G
T
Q
K
---
L
A
-
Q
A
A
L
L
Y
M
-----
G
S
-
K
L
T
S
-
D
E
T
K
E
L
T
A
I
F
-
K
M
D
--------
D
G
Q
L
D
R
A
E
L
I
E
G
-
Y
K
E
L
M
----------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
50.14
33%
-73
- C2 -
-
5O1S
2
A:
[41-336]
---------
Q
F
T
D
G
Y
E
V
K
E
D
-
I
------
S
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
--
I
D
K
S
---
K
------------
R
----
D
--------------
P
T
E
----
E
I
E
I
L
-
L
R
Y
G
-
Q
-
H
-
P
N
I
I
T
L
K
D
V
Y
D
D
--
G
K
Y
V
-----
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
--
K
----
F
-
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
V
D
E
S
-
G
-
N
P
E
-
S
-
I
R
I
C
D
F
G
F
A
--
K
Q
L
R
A
E
N
G
L
L
M
--
T
P
C
----
N
F
V
A
P
E
V
L
-----
E
------
R
---
Q
G
Y
-
D
A
A
-
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
------
A
NGP
D
-
D
--
T
-----
P
E
-------
E
I
L
A
R
I
-
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
A
L
V
L
R
H
P
W
I
----
V
----
H
W
D
----
Q
L
P
Q
Y
-
Q
-------------------
L
N
R
Q
D
A
P
H
L
V
K
-------
G
A
M
A
A
T
Y
---
S
A
L
N
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
50.02
37%
-90
- C2 -
-
3KN5
1
B:
[19-282]
---------------------
L
-
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
--
I
-
S
K
---
R
-
M
--
E
------
A
-----
N
T
---------
Q
---
K
E
I
----
T
A
L
K
L
-
C
E
---
G
-
H
-
P
N
I
V
K
L
H
E
V
F
H
D
--
Q
L
H
T
-----
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
K
K
K
--
K
----
H
-
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
-------
L
-
E
-
I
K
I
I
D
F
G
F
A
--
R
L
K
P
P
---------------------------------------
N
G
Y
-
D
E
S
-
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
------
Q
---
S
-
H
--
D
-----
R
S
LTCTSAV
E
I
M
K
K
I
-
K
K
G
D
F
S
F
E
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
M
S
G
L
R
Y
N
E
W
L
----
Q
----
D
G
S
----
Q
L
S
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
338
Blastp_CBE
49.97
36%
-38
- C2 -
-
6QF4
2
ST17B_HUMAN
A:
[35-305]
------------------
K
E
-
L
-
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
--
L
K
K
R
---
R
-
R
--
G
------
Q
D
----
C
R
---------
A
---
E
I
L
----
H
E
I
A
V
-
L
E
L
A
-
K
-
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
--
T
S
E
I
-----
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
E
LA
E
----
M
-
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
L
S
S
I
Y
-
P
-
L
-
G
-
D
-
I
K
I
V
D
F
G
M
S
--
R
K
I
-
G
H
A
C
------
I
M
-
G
T
P
E
Y
L
A
P
E
I
L
-----
N
------
Y
---
D
P
I
-
T
T
A
-
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
------
V
---
G
-
E
--
D
-----
N
Q
-------
E
T
Y
L
N
I
-
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
---------
Q
Q
W
----
D
F
E
N
L
-
F
---
H
P
E
E
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
49.92
39%
-98
- C2 -
-
2CN8
1
CHK2_HUMAN
A:
[16-284]
------------
D
E
Y
I
M
S
K
T
-
L
-
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
-------------------------------------
N
V
E
----
T
E
I
E
I
-
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
D
Y
------
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
-
D
-
C
-
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
T
S
L
M
R
--
T
L
C
---
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
---
E
H----------
V
-------
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
Blastp_CBE
49.92
44%
-36
- C2 -
-
3MA6
1
?
A:
[30-291]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
-
S
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
49.79
38%
19
- C2 -
-
2CKE
1
DAPK2_HUMAN
C:
[12-302]
------------
D
F
Y
D
I
G
E
E
-
L
-
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
-
S
--
R
------
A
S
RRGV
S
R
---------
E
---
E
I
E
----
R
E
V
S
I
-
L
R
Q
V
-
L
-
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
--
R
T
D
V
-----
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
--
E
----
S
-
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
-
I
-
P
-
I
-
P
H
I
K
L
I
D
F
G
L
A
--
H
E
I
E
-
D
G
V
E
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
I
-
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
----
T
----
P
V
D
----
N
Q
Q
A
M
-
V
---
R
R
E
S
V
V
N
L
EN------
F
R
K
Q
Y
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
49.72
38%
19
- C2 -
-
2CKE
1
DAPK2_HUMAN
A:
[12-302]
------------
D
F
Y
D
I
G
E
E
-
L
-
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
-
S
--
R
------
A
S
RRGV
S
R
---------
E
---
E
I
E
----
R
E
V
S
I
-
L
R
Q
V
-
L
-
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
--
R
T
D
V
-----
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
--
E
----
S
-
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
-
I
-
P
-
I
-
P
H
I
K
L
I
D
F
G
L
A
--
H
E
I
E
-
D
G
V
E
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
I
-
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
----
T
----
P
V
D
----
N
Q
Q
A
M
-
V
---
R
R
E
S
V
V
N
L
EN------
F
R
K
Q
Y
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
192
Blastp_CBE
49.70
38%
15
- C2 -
-
2CKE
1
DAPK2_HUMAN
D:
[12-302]
------------
D
F
Y
D
I
G
E
E
-
L
-
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
-
S
--
R
------
A
S
RRGV
S
R
---------
E
---
E
I
E
----
R
E
V
S
I
-
L
R
Q
V
-
L
-
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
--
R
T
D
V
-----
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
--
E
----
S
-
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
-
I
-
P
-
I
-
P
H
I
K
L
I
D
F
G
L
A
--
H
E
I
E
-
D
G
V
E
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
I
-
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
----
T
----
P
V
D
----
N
Q
Q
A
M
-
V
---
R
R
E
S
V
V
N
L
EN------
F
R
K
Q
Y
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
49.15
41%
-4
- C2 -
-
2Y7J
1
PHKG2_HUMAN
C:
[92-363]
----------
F
Y
Q
K
Y
D
P
K
D
V
-
I
-
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
ME
V
T
A
E
---
R
-
L
--
S
------
P
E
----
Q
L
---------
E
---
E
V
R
EATR
R
E
T
H
I
-
L
R
Q
V
-
A
G
H
-
P
H
I
I
T
L
I
D
S
Y
E
S
--
S
S
F
M
-----
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
--
V
----
A
-
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
-
D
-
N
-
M
-
Q
-
I
R
L
S
D
F
G
F
S
--
C
H
L
E
P
G
E
K
L
R
---
E
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
-----
K
CSMDET
H
---
P
G
Y
-
G
K
E
-
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
------
W
---
H
-
R
--
R
-----
Q
I
-------
L
M
L
R
M
I
-
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
49.14
39%
-35
- C2 -
-
5VJA
3
DAPK3_HUMAN
D:
[5-269]
------------
D
H
Y
E
M
G
E
E
-
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
---
R
-
L
--
S
--------V---
S
R
---------
E
---
E
I
E
----
R
E
V
N
I
-
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
--
K
T
D
V
-----
V
L
I
L
E
L
V
S
G
G
E
L
F
D
---
E
K
--
E
----
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
--V
P
-
N
-
P
-
R
-
I
K
L
I
D
F
G
I
A
--
H
K
I
E
A
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
E
--
T
-----
K
Q
-------
E
T
L
T
N
I
-
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
Blastp_CBE
49.02
44%
-39
- C2 -
-
3MA6
1
?
B:
[30-291]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
-T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
M
K
D
--
K
I
--
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
----------
G
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
48.92
37%
-89
- C2 -
-
3KN5
1
KS6A5_HUMAN
A:
[19-282]
---------------------
L
-
G
E
G
S
F
S
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
--
I
-
S
K
---
R
-
M
--
E
------
A
-----
N
T
---------
Q
---
K
E
I
----
T
A
L
K
L
-
C
E
---
G
-
H
-
P
N
I
V
K
L
H
E
V
F
H
D
--
Q
L
H
T
-----
F
L
V
M
E
L
L
N
G
G
E
L
F
E
R
I
K
K
K
--
K
----
H
-
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
T
D
-------
L
-
E
-
I
K
I
I
D
F
G
F
A
--
R
L
K
P
P
---------------------------------------
N
G
Y
-
D
E
S
-
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
------
Q
----------------CTSAV--
E
I
M
K
K
I
-
K
K
G
D
F
S
F
E
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
L
K
M
S
G
L
R
Y
N
E
W
L
----
Q
----
D
G
S
----
Q
L
S
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
194
Blastp_CBE
48.87
38%
15
- C2 -
-
2CKE
1
DAPK2_HUMAN
B:
[12-302]
------------
D
F
Y
D
I
G
E
E
-
L
-
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
-
S
--
R
------
A
S
RRGV
S
R
---------
E
---
E
I
E
----
R
E
V
S
I
-
L
R
Q
V
-
L
-
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
--
R
T
D
V
-----
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
--
E
----
S
-
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
-
I
-
P
-
I
-
P
H
I
K
L
I
D
F
G
L
A
--
H
E
I
E
-
D
G
V
E
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
I
-
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
----
T
----
P
V
D
----
N
Q
Q
A
M
-
V
---
R
R
E
S
V
V
N
L
EN------
F
R
K
Q
Y
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
340
Blastp_CBE
48.75
36%
-41
- C2 -
-
3LM0
2
ST17B_HUMAN
A:
[35-302]
------------------
K
E
-
L
-
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
--
L
K
K
R
---
R
-
R
--
G
------
Q
D
----
C
R
---------
A
---
E
I
L
----
H
E
I
A
V
-
L
E
L
A
-
K
-
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
--
T
S
E
I
-----
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
E
LA
E
----
M
-
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
L
S
S
I
Y
-
P
-
L
-
G
-
D
-
I
K
I
V
D
F
G
M
S
--
R
K
------------
I
M
-
G
T
P
E
Y
L
A
P
E
I
L
-----
N
------
Y
---
D
P
I
-
T
T
A
-
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
------
V
---
G
-
E
--
D
-----
N
Q
-------
E
T
Y
L
N
I
-
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
---------
Q
Q
W
----
D
F
E
N
L
-
F
---
H
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
48.66
41%
-4
- C2 -
-
2Y7J
1
PHKG2_HUMAN
A:
[92-363]
----------
F
Y
Q
K
Y
D
P
K
D
V
-
I
-
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
ME
V
T
A
E
---
R
-
L
--
S
------
P
E
----
Q
L
---------
E
---
E
V
R
EATR
R
E
T
H
I
-
L
R
Q
V
-
A
G
H
-
P
H
I
I
T
L
I
D
S
Y
E
S
--
S
S
F
M
-----
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
--
V
----
A
-
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
-
D
-
N
-
M
-
Q
-
I
R
L
S
D
F
G
F
S
--
C
H
L
E
P
G
E
K
L
R
---
E
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
-----
K
CSMDET
H
---
P
G
Y
-
G
K
E
-
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
------
W
---
H
-
R
--
R
-----
Q
I
-------
L
M
L
R
M
I
-
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
48.60
41%
22
- C2 -
-
1PHK
1
PHKG1_RABIT
A:
[15-291]
----------
F
Y
E
N
Y
E
P
K
E
I
-
L
-
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
--
I
D
V
T
GGG
S
-
F
--
S
------
A
E
----
E
V
---------
Q
---
E
L
R
EATL
K
E
V
D
I
-
L
R
K
V
-
S
G
H
-
P
N
I
I
Q
L
K
D
T
Y
E
T
--
N
T
F
F
-----
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
--
V
----
T
-
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
-
D
-
D
-
M
-
N
-
I
K
L
T
D
F
G
F
S
--
C
Q
L
D
P
G
E
K
L
R
---
E
V
C
-
G
T
P
S
Y
L
A
P
E
I
I
-----
E
CSMNDN
H
---
P
G
Y
-
G
K
E
-
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
------
W
---
H
-
R
--
K
-----
Q
M
-------
L
M
L
R
M
I
-
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
---------
Q
Q
Y
----
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
48.52
37%
20
- C2 -
-
2YAA
1
DAPK2_MOUSE
B:
[12-302]
------------
D
F
Y
D
I
G
E
E
-
L
-
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
-
S
--
R
------
A
S
----
R
R
GVCR-----
E
---
E
I
E
----
R
E
V
S
I
-
L
R
Q
V
-
L
-
H
-
P
N
I
I
T
L
H
D
V
Y
E
N
--
R
T
D
V
-----
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
--
E
----
S
-
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
-
I
-
P
-
I
-
P
H
I
K
L
I
D
F
G
L
A
--
H
E
I
E
-
D
G
V
E
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
I
-
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
----
T
----
P
V
D
----
T
Q
Q
A
M
-
V
---
R
R
E
S
V
V
N
L
EN------
F
K
K
Q
Y
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
291
Blastp_CBE
48.46
39%
-104
- C2 -
-
2XM8
1
CHK2_HUMAN
A:
[16-284]
------------
D
E
Y
I
M
S
K
T
-
L
-
G
-----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
------------------------------------------
N
V
E
----
T
E
I
E
I
-
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
D
Y
------
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
-
D
-
C
-
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
T
S
L
M
R
--
T
L
C
-
G
---
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
---
E
H
R
--
T
-----
Q
V
-------
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
48.42
41%
-4
- C2 -
-
2Y7J
1
PHKG2_HUMAN
B:
[92-363]
----------
F
Y
Q
K
Y
D
P
K
D
V
-
I
-
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
ME
V
T
A
---------
S
------
P
E
----
Q
L
---------
E
---
E
V
R
EATR
R
E
T
H
I
-
L
R
Q
V
-
A
G
H
-
P
H
I
I
T
L
I
D
S
Y
E
S
--
S
S
F
M
-----
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
--
V
----
A
-
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
-
D
-
N
-
M
-
Q
-
I
R
L
S
D
F
G
F
S
--
C
H
L
E
P
G
E
K
L
R
---
E
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
-----
K
CSMDET
H
---
P
G
Y
-
G
K
E
-
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
------
W
---
H
-
R
--
R
-----
Q
I
-------
L
M
L
R
M
I
-
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
48.32
41%
21
- C2 -
-
1QL6
1
PHKG1_RABIT
A:
[15-291]
----------
F
Y
E
N
Y
E
P
K
E
I
-
L
-
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
--
I
D
V
T
GGG
S
-
F
--
S
------
A
E
----
E
V
---------
Q
---
E
L
R
EATL
K
E
V
D
I
-
L
R
K
V
-
S
G
H
-
P
N
I
I
Q
L
K
D
T
Y
E
T
--
N
T
F
F
-----
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
--
V
----
T
-
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
-
D
-
D
-
M
-
N
-
I
K
L
T
D
F
G
F
S
--
C
Q
L
D
P
G
E
K
L
R
---
S
V
C
-
G
T
P
S
Y
L
A
P
E
I
I
-----
E
CSMNDN
H
---
P
G
Y
-
G
K
E
-
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
------
W
---
H
-
R
--
K
-----
Q
M
-------
L
M
L
R
M
I
-
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
---------
Q
Q
Y
----
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
603
HHSearch
48.24
42%
-9
- C2 -
-
2Y7J
1
PHKG2_HUMAN
A:
[91-364]
---------
E
F
Y
Q
K
Y
D
P
K
D
V
-
I
-
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
--
M
E
V
T
---
A
-
E
--
R
LSPEQL
E
E
----
V
R
---------
E
---
A
T
R
----
R
E
T
H
I
-
L
R
Q
V
A
G
-
H
-
P
H
I
I
T
L
I
D
S
Y
E
S
--
S
S
F
M
-----
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
--
V
----
A
-
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
-----
N
-
M
-
Q
-
I
R
L
S
D
F
G
F
S
--
C
H
L
E
P
G
E
-
K
L
R
--
E
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
-----
K
CSMDET
H
---
P
G
Y
-
G
K
E
-
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
------
W
---
H
-
R
--
R
-----
Q
I
-------
L
M
L
R
M
I
-
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
----
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
159
Blastp_CBE
48.16
37%
19
- C2 -
-
2YAA
1
DAPK2_MOUSE
A:
[12-302]
------------
D
F
Y
D
I
G
E
E
-
L
-
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
--
I
K
K
R
---
Q
-
S
--
R
------
A
S
----
R
R
GVCR-----
E
---
E
I
E
----
R
E
V
S
I
-
L
R
Q
V
-
L
-
H
-
P
N
I
I
T
L
H
D
V
Y
E
N
--
R
T
D
V
-----
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
--
E
----
S
-
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
-
I
-
P
-
I
-
P
H
I
K
L
I
D
F
G
L
A
--
H
E
I
E
-
D
G
V
E
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
I
-
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
----
T
----
P
V
D
----
T
Q
Q
A
M
-
V
---
R
R
E
S
V
V
N
L
EN------
F
K
K
Q
Y
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
47.97
36%
7
- C2 -
-
3EHA
1
DAPK1_HUMAN
A:
[10-293]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-------
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
D
----
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
478
Blastp_CBE
47.83
37%
-34
- C2 -
-
6C9H
2
AAPK1_HUMAN
A:
[16-320]
--------------
Y
I
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
---
K
-
I
--
R
------
S
L
----
D
V
V--------
G
---
K
I
R
----
R
E
I
Q
N
-
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
S
D
I
-----
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
-
N
-
A
------
K
I
A
D
F
G
L
S
---
N
M
M
S
D
G
E
F
L
R
--
T
S
C
-
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
---
D
-
D
--
H
-----
V
P
-------
T
L
F
K
K
I
-
C
D
G
I
--
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
----
K
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
47.68
41%
23
- C2 -
-
2PHK
2
PHKG1_RABIT
A:
[2-276]
----------
F
Y
E
N
Y
E
P
K
E
I
-
L
-
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
--
I
D
V
T
GGG
S
-
F
--
S
------
A
E
----
E
V
---------
Q
---
E
L
R
EATL
K
E
V
D
I
-
L
R
K
V
-
S
G
H
-
P
N
I
I
Q
L
K
D
T
Y
E
T
--
N
T
F
F
-----
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
--
V
----
T
-
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
-
D
-
D
-
M
-
N
-
I
K
L
T
D
F
G
F
S
--
C
Q
L
D
P
G
E
K
L
R
---
E
V
C
-
G
T
P
S
Y
L
A
P
E
I
I
-----
E
CSMNDN
H
---
P
G
Y
-
G
K
E
-
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
------
W
---
H
-
R
--
K
-----
Q
M
-------
L
M
L
R
M
I
-
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
----
Q
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
183
Blastp_CBE
47.52
41%
-3
- C2 -
-
2Y7J
1
PHKG2_HUMAN
D:
[92-363]
----------
F
Y
Q
K
Y
D
P
K
D
V
-
I
-
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
ME
V
------
R
-
L
--
S
------
P
E
----
Q
L
---------
E
---
E
V
R
EATR
R
E
T
H
I
-
L
R
Q
V
-
A
G
H
-
P
H
I
I
T
L
I
D
S
Y
E
S
--
S
S
F
M
-----
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
--
V
----
A
-
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
-
D
-
N
-
M
-
Q
-
I
R
L
S
D
F
G
F
S
--
C
H
L
E
P
G
E
K
L
R
---
E
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
-----
K
CSMDET
H
---
P
G
Y
-
G
K
E
-
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
------
W
---
H
-
R
--
R
-----
Q
I
-------
L
M
L
R
M
I
-
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
47.30
39%
-3
- C2 -
-
5VJA
2
DAPK3_HUMAN
B:
[5-269]
------------
D
H
Y
E
M
G
E
E
-
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
-----------------RGV-
S
R
---------
E
---
E
I
E
----
R
E
V
N
I
-
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
--
K
T
D
V
-----
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
-
N
-
P
-
R
-
I
K
L
I
D
F
G
I
A
--
H
K
I
E
A
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
E
--
T
-----
K
Q
-------
E
T
L
T
N
I
-
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
47.01
36%
9
- C2 -
-
3EH9
1
DAPK1_HUMAN
A:
[10-293]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
-RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-------
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
D
----
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
235
Blastp_CBE
46.99
36%
10
- C2 -
-
5AV2
1
DAPK1_HUMAN
A:
[11-277]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-------
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
46.97
36%
8
- C2 -
-
5AV3
1
DAPK1_HUMAN
A:
[11-277]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-------
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
46.93
38%
-27
- C2 -
-
4CZT
3
CIPKN_ARATH
C:
[12-268]
-------------
K
Y
E
L
G
R
T
-
L
-
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
--
I
D
K
E
---
K
V
L
--
K
------
N
K
----
M
I
---------
A
---
Q
I
K
----
R
E
I
S
T
-
M
K
L
I
-
K
-
H
-
P
N
V
I
R
M
F
E
V
M
A
S
--
K
T
K
I
-----
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
--
G
----
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
N
------
G
-
A
-
L
K
V
S
D
F
G
L
S
--
A
L
P
Q
Q
V
R
E
D
G
L
LH
T
T
C
-
G
T
P
N
Y
V
A
P
E
V
I
-----
N
------
N
---
K
G
Y
D
G
A
K
-
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
------
E
---
D
-
S
--
N
-----
L
T
-------
S
L
Y
K
K
I
F
K
A
---
E
F
T
C
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
46.89
36%
9
- C2 -
-
3F5G
1
DAPK1_HUMAN
A:
[10-293]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-------
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
D
----
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
46.84
35%
16
- C2 -
-
6QN4
4
DAPK1_HUMAN
A:
[4-280]
-
A
T
V
F
R
Q
E
-
N
V
D
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
46.83
36%
-46
- C2 -
-
3ZXT
1
DAPK1_HUMAN
D:
[11-276]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
--------------------V---
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
-----------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
--------------
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
479
Blastp_CBE
46.81
37%
-32
- C2 -
-
4REW
1
AAPK1_HUMAN
A:
[8-391]
--------------
Y
I
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
---
K
-
I
--
R
------
S
L
----
D
V
V--------
G
---
K
I
R
----
R
E
I
Q
N
-
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
S
D
I
-----
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
-
N
-
A
------
K
I
A
D
F
G
L
S
---
N
M
M
S
D
G
E
F
L
R
--
T
S
C
-
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
---
D
-
D
--
H
-----
V
P
-------
T
L
F
K
K
I
-
C
D
G
I
--
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
S
I
K
D
I
R
E
H
E
W
F
----
K
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
240
Blastp_CBE
46.74
36%
9
- C2 -
-
5AUX
1
DAPK1_HUMAN
A:
[11-277]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-------
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
46.69
36%
8
- C2 -
-
5AUV
1
DAPK1_HUMAN
A:
[11-277]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-------
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
46.67
36%
13
- C2 -
-
3DFC
1
DAPK1_HUMAN
B:
[11-294]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
K
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
D
----
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
46.60
36%
11
- C2 -
-
5AUT
1
DAPK1_HUMAN
A:
[11-277]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
----
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
305
Blastp_CBE
46.59
36%
18
- C2 -
-
3GU8
1
DAPK1_HUMAN
A:
[11-293]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
---------
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
46.51
37%
-54
- C2 -
-
6CJH
1
MKNK2_HUMAN
A:
[9-299]
---------
R
F
E
D
V
Y
Q
L
Q
E
D
V
L
-
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
--
I
E
K
Q
---
P
-
G
--
H
------
I
R
----
S
R
---------
V
---
F
R
E
----
V
E
M
-
L
-
Y
Q
C
Q
-
G
-
H
-
R
N
V
L
E
L
I
E
F
F
E
E
--
E
D
R
F
-----
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
--
R
----
H
-
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
N
-
Q
-
V
-
S
-
P
-
V
K
I
C
D
F
G
---------------------
G
S
A
E
Y
M
A
P
E
V
V
EAFSE
E
------
A
---
S
I
Y
-
D
K
R
-
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG----------ACPAC
Q
N
-------
M
L
F
E
S
I
-
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
46.44
36%
18
- C2 -
-
1WVY
1
DAPK1_HUMAN
A:
[11-275]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
46.43
36%
11
- C2 -
-
3GU6
1
DAPK1_HUMAN
A:
[11-294]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
D
----
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
351
Blastp_CBE
46.41
37%
-51
- C2 -
-
2HW7
1
MKNK2_HUMAN
A:
[9-299]
---------
R
F
E
D
V
Y
Q
L
Q
E
D
V
L
-
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
--
I
E
K
Q
---
P
-
G
--
H
------
I
R
----
S
R
---------
V
---
F
R
E
----
V
E
M
-
L
-
Y
Q
C
Q
-
G
-
H
-
R
N
V
L
E
L
I
E
F
F
E
E
--
E
D
R
F
-----
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
--
R
----
H
-
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
N
-
Q
-
V
-
S
-
P
-
V
K
I
C
D
F
G
---------------------
G
S
A
E
Y
M
A
P
E
V
V
EAFSE
E
------
A
---
S
I
Y
-
D
K
R
-
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG----------ACPAC
Q
N
-------
M
L
F
E
S
I
-
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
46.32
36%
7
- C2 -
-
5AUZ
1
DAPK1_HUMAN
A:
[11-277]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
----
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
219
Blastp_CBE
46.32
34%
23
- C2 -
-
6FHB
2
DAPK1_HUMAN
A:
[4-296]
-
A
T
V
F
R
Q
E
-
N
V
D
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
D
----
T
Q
Q
A
L
-
S
---
R
K
A
A
A
V
N
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
545
Blastp_CBE
46.29
31%
-19
- C2 -
-
2ZV2
1
KKCC2_HUMAN
A:
[10-298]
-------
V
-
Q
L
-
N
Q
Y
T
L
K
D
E
-
I
-
G
K
--
Y
G
V
V
K
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
--
L
S
K
K
--------------------------------
E
---
Q
V
Y
----
Q
E
I
A
I
-
L
K
K
L
-
D
-
H
-
P
N
V
V
K
L
V
E
V
L
D
D
PN
E
D
H
L
-----
Y
M
V
F
E
L
V
N
Q
G
P
V
M
E
-
V
P
T
L
--
K
----
P
-
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
G
----
E
-
D
-
G
-
H
-
I
K
I
A
D
F
G
V
S
--
N
E
F
K
G
S
D
A
L
L
S
--
N
T
V
-
G
T
P
A
F
M
A
P
E
S
L
SET--
R
------
K
---
I
F
S
-
G
K
A
-
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
------
M
---
D
-
E
--
R
-----
I
M
-------
C
L
H
S
K
I
-
K
S
Q
A
L
E
F
--
P
D
Q
P
D
I
A
E
D
L
K
D
L
I
T
R
M
L
D
K
N
P
E
S
R
I
V
V
P
E
I
K
L
H
P
W
V
----
T
----
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
203
Blastp_CBE
46.27
35%
23
- C2 -
-
2W4K
1
DAPK1_HUMAN
A:
[11-302]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
D
----
T
Q
Q
A
L
-
S
---
R
K
A
S
A
V
N
M
EK------
F
K
K
F
A
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
46.25
39%
19
- C2 -
-
5VJA
2
DAPK3_HUMAN
A:
[5-269]
------------
D
H
Y
E
M
G
E
E
-
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
-----------------RRGV
S
R
---------
E
---
E
I
E
----
R
E
V
N
I
-
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
--
K
T
D
V
-----
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
-
N
-
P
-
R
-
I
K
L
I
D
F
G
I
A
--
H
K
I
E
A
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
E
--
T
-----
K
Q
-------
E
T
L
T
N
I
-
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
46.23
36%
11
- C2 -
-
3GUB
1
DAPK1_HUMAN
A:
[11-293]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
---------
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
46.23
36%
7
- C2 -
-
5AUW
1
DAPK1_HUMAN
A:
[11-277]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
46.22
39%
-17
- C2 -
-
4A9R
2
CHK2_HUMAN
A:
[16-284]
------------
D
E
Y
I
M
S
K
T
-
L
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
----------------------------------PAL
N
V
E
----
T
E
I
E
I
-
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
D
Y
------
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
-
D
-
C
-
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
T
S
L
M
R
--
T
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
---
E
H
R
--
T
-----
Q
V
-------
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
46.16
36%
4
- C2 -
-
5AV4
1
DAPK1_HUMAN
A:
[11-277]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
----
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
237
Blastp_CBE
46.12
36%
13
- C2 -
-
5AV0
1
DAPK1_HUMAN
A:
[11-277]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-------
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
46.10
36%
14
- C2 -
-
4YO4
1
DAPK1_HUMAN
A:
[10-294]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
D
----
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
46.05
38%
-16
- C2 -
-
4CZU
3
CIPKN_ARATH
D:
[12-272]
-------------
K
Y
E
L
G
R
T
-
L
-
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
--
I
D
K
E
---
K
V
L
--
K
------
N
K
----
M
I
---------
A
---
Q
I
K
----
R
E
I
S
T
-
M
K
L
I
-
K
-
H
-
P
N
V
I
R
M
F
E
V
M
A
S
--
K
T
K
I
-----
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
--
G
----
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
N
------
G
-
A
-
L
K
V
S
D
F
G
L
S
--
A
L
P
Q
Q
V
R
E
D
G
L
LH
D
T
C
-
G
T
P
N
Y
V
A
P
E
V
I
-----
N
------
N
---
K
G
Y
D
G
A
K
-
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
------
E
---
D
-
S
--
N
-----
L
T
-------
S
L
Y
K
K
I
F
K
A
---
E
F
T
C
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
46.02
39%
11
- C2 -
-
3BQR
4
DAPK3_HUMAN
A:
[5-269]
------------
D
H
Y
E
M
G
E
E
-
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
---
R
-
L
--
S
------
S
S
RRGV
S
R
---------
E
---
E
I
E
----
R
E
V
N
I
-
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
--
K
T
D
V
-----
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
-
N
-
P
-
R
-
I
K
L
I
D
F
G
I
A
--
H
K
I
E
A
G
N
------
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
E
--
T
-----
K
Q
-------
E
T
L
T
N
I
-
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
172
Blastp_CBE
46.01
39%
7
- C2 -
-
3BHY
1
DAPK3_HUMAN
A:
[5-269]
------------
D
H
Y
E
M
G
E
E
-
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
---
R
-
L
--
S
------
S
S
RRGV
S
R
---------
E
---
E
I
E
----
R
E
V
N
I
-
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
--
K
T
D
V
-----
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
-
N
-
P
-
R
-
I
K
L
I
D
F
G
I
A
--
H
K
I
E
-----------
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
E
--
T
-----
K
Q
-------
E
T
L
T
N
I
-
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
45.91
36%
6
- C2 -
-
5AUU
1
DAPK1_HUMAN
A:
[11-277]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
----
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
45.86
35%
19
- C2 -
-
4B4L
3
DAPK1_HUMAN
A:
[13-295]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
D
----
T
Q
Q
A
L
-
S
---
R
K
A
S
A
V
N
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
581
Blastp_CBE
45.83
32%
-8
- C2 -
-
5OS2
2
AURKA_HUMAN
A:
[5-265]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
--------
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
45.78
36%
13
- C2 -
-
5AUY
1
DAPK1_HUMAN
A:
[11-277]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-------
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
167
Blastp_CBE
45.77
39%
14
- C2 -
-
5A6O
2
DAPK3_HUMAN
B:
[5-269]
------------
D
H
Y
E
M
G
E
E
-
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
---
R
-
L
--
S
------
S
S
RRGV
S
R
---------
E
---
E
I
E
----
R
E
V
N
I
-
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
--
K
T
D
V
-----
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
-
N
-
P
-
R
-
I
K
L
I
D
F
G
I
A
--
H
K
I
E
------
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
E
--
T
-----
K
Q
-------
E
T
L
T
N
I
-
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
45.73
36%
16
- C2 -
-
4YPD
1
DAPK1_HUMAN
A:
[10-294]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
D
----
T
Q
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
529
Blastp_CBE
45.69
31%
-6
- C2 -
-
6R49
2
AURKA_HUMAN
A:
[13-273]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
----------
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
45.68
39%
-18
- C2 -
-
2XM9
1
CHK2_HUMAN
A:
[16-284]
------------
D
E
Y
I
M
S
K
T
-
L
-
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
----------------------------------PAL
N
V
E
----
T
E
I
E
I
-
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
D
Y
------
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
-
D
-
C
-
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
T
S
L
M
R
--
T
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
---
E
H
R
--
T
-----
Q
V
-------
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
45.68
35%
20
- C2 -
-
2Y0A
1
DAPK1_HUMAN
A:
[11-293]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
D
----
T
Q
Q
A
L
-
S
---
R
K
A
S
A
V
N
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
164
Blastp_CBE
45.66
39%
13
- C2 -
-
5VJA
2
DAPK3_HUMAN
C:
[5-269]
------------
D
H
Y
E
M
G
E
E
-
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
---
R
-
L
--
S
------
S
-GV--
S
R
---------
E
---
E
I
E
----
R
E
V
N
I
-
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
--
K
T
D
V
-----
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
--
E
K
--
E
----
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
--V
P
-
N
-
P
-
R
-
I
K
L
I
D
F
G
I
A
--
H
K
I
E
A
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
E
--
T
-----
K
Q
-------
E
T
L
T
N
I
-
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
45.65
36%
18
- C2 -
-
1IG1
1
DAPK1_HUMAN
A:
[10-293]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
D
----
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
45.64
36%
18
- C2 -
-
2YAK
1
DAPK1_HUMAN
A:
[11-278]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
168
Blastp_CBE
45.64
39%
11
- C2 -
-
5A6O
3
DAPK3_HUMAN
A:
[5-269]
------------
D
H
Y
E
M
G
E
E
-
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
---
R
-
L
--
S
------
S
S
RRGV
S
R
---------
E
---
E
I
E
----
R
E
V
N
I
-
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
--
K
T
D
V
-----
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
-
N
-
P
-
R
-
I
K
L
I
D
F
G
I
A
--
H
K
I
E
------
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
E
--
T
-----
K
Q
-------
E
T
L
T
N
I
-
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
274
Blastp_CBE
45.62
36%
11
- C2 -
-
4PF4
6
DAPK1_HUMAN
A:
[12-276]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
45.61
36%
14
- C2 -
-
3GU4
1
DAPK1_HUMAN
A:
[11-294]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
D
----
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
45.53
37%
-49
- C2 -
-
6CK3
1
MKNK2_HUMAN
A:
[9-299]
---------
R
F
E
D
V
Y
Q
L
Q
E
D
V
L
-
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
--
I
E
K
Q
---
P
-
G
--
H
------
I
R
----
S
R
---------
V
---
F
R
E
----
V
E
M
-
L
-
Y
Q
C
Q
-
G
-
H
-
R
N
V
L
E
L
I
E
F
F
E
E
--
E
D
R
F
-----
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
--
R
----
H
-
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
N
-
Q
-
V
-
S
-
P
-
V
K
I
C
D
F
G
---------------------
G
S
A
E
Y
M
A
P
E
V
V
EAFSE
E
------
A
---
S
I
Y
-
D
K
R
-
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG----------ACPAC
Q
N
-------
M
L
F
E
S
I
-
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
45.53
37%
-49
- C2 -
-
6CK6
1
MKNK2_HUMAN
A:
[9-299]
---------
R
F
E
D
V
Y
Q
L
Q
E
D
V
L
-
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
--
I
E
K
Q
---
P
-
G
--
H
------
I
R
----
S
R
---------
V
---
F
R
E
----
V
E
M
-
L
-
Y
Q
C
Q
-
G
-
H
-
R
N
V
L
E
L
I
E
F
F
E
E
--
E
D
R
F
-----
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
--
R
----
H
-
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
N
-
Q
-
V
-
S
-
P
-
V
K
I
C
D
F
G
---------------------
G
S
A
E
Y
M
A
P
E
V
V
EAFSE
E
------
A
---
S
I
Y
-
D
K
R
-
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG----------ACPAC
Q
N
-------
M
L
F
E
S
I
-
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
45.50
36%
15
- C2 -
-
1JKL
1
DAPK1_HUMAN
A:
[10-293]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
D
----
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
268
Blastp_CBE
45.49
36%
24
- C2 -
-
4TXC
7
DAPK1_HUMAN
A:
[30-296]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
299
Blastp_CBE
45.45
35%
23
- C2 -
-
4UV0
1
DAPK1_HUMAN
A:
[13-289]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
D
----
T
Q
Q
A
L
-
S
---
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
169
Blastp_CBE
45.43
39%
15
- C2 -
-
5A6N
1
DAPK3_HUMAN
B:
[5-269]
------------
D
H
Y
E
M
G
E
E
-
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
---
R
-
L
--
S
------
S
S
RRGV
S
R
---------
E
---
E
I
E
----
R
E
V
N
I
-
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
--
K
T
D
V
-----
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
-
N
-
P
-
R
-
I
K
L
I
D
F
G
I
A
--
H
K
I
E
------
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
E
--
T
-----
K
Q
-------
E
T
L
T
N
I
-
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
218
Blastp_CBE
45.39
35%
24
- C2 -
-
2XUU
1
DAPK1_HUMAN
A:
[11-293]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
A
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
D
----
T
Q
Q
A
L
-
S
---
R
K
A
S
A
V
N
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
343
Blastp_CBE
45.36
37%
-45
- C2 -
-
6CKI
1
MKNK2_HUMAN
A:
[9-299]
---------
R
F
E
D
V
Y
Q
L
Q
E
D
V
L
-
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
--
I
E
K
Q
---
P
-
G
--
H
------
I
R
----
S
R
---------
V
---
F
R
E
----
V
E
M
-
L
-
Y
Q
C
Q
-
G
-
H
-
R
N
V
L
E
L
I
E
F
F
E
E
--
E
D
R
F
-----
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
--
R
----
H
-
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
N
-
Q
-
V
-
S
-
P
-
V
K
I
C
D
F
G
---------------------
G
S
A
E
Y
M
A
P
E
V
V
EAFSE
E
------
A
---
S
I
Y
-
D
K
R
-
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG----------ACPAC
Q
N
-------
M
L
F
E
S
I
-
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
45.31
38%
-21
- C2 -
-
4CZU
3
CIPKN_ARATH
C:
[12-273]
-------------
K
Y
E
L
G
R
T
-
L
-
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
--
I
D
K
E
---
K
V
L
--
K
------
N
K
----
M
I
---------
A
---
Q
I
K
----
R
E
I
S
T
-
M
K
L
I
-
K
-
H
-
P
N
V
I
R
M
F
E
V
M
A
S
--
K
T
K
I
-----
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
--
G
----
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
N
------
G
-
A
-
L
K
V
S
D
F
G
L
S
--
A
L
P
Q
Q
V
R
E
D
G
L
LH
D
T
C
-
G
T
P
N
Y
V
A
P
E
V
I
-----
N
------
N
---
K
G
Y
D
G
A
K
-
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
------
E
---
D
-
S
--
N
-----
L
T
-------
S
L
Y
K
K
I
F
K
A
---
E
F
T
C
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
45.32
36%
18
- C2 -
-
3GU7
1
DAPK1_HUMAN
A:
[11-294]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
D
----
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
45.31
39%
-15
- C2 -
-
4A9T
4
CHK2_HUMAN
A:
[16-284]
------------
D
E
Y
I
M
S
K
T
-
L
-
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
----------------------------------PAL
N
V
E
----
T
E
I
E
I
-
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
D
Y
------
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
-
D
-
C
-
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
T
S
L
M
R
--
T
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
---
E
H
R
--
T
-----
Q
V
-------
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
45.29
36%
13
- C2 -
-
1JKK
1
DAPK1_HUMAN
A:
[10-292]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
45.28
36%
16
- C2 -
-
3GU5
1
DAPK1_HUMAN
A:
[11-294]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
V
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
D
----
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
170
Blastp_CBE
45.25
39%
21
- C2 -
-
5A6N
4
DAPK3_HUMAN
A:
[5-269]
------------
D
H
Y
E
M
G
E
E
-
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
---
R
-
L
--
S
------
S
S
RRGV
S
R
---------
E
---
E
I
E
----
R
E
V
N
I
-
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
--
K
T
D
V
-----
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
-
N
-
P
-
R
-
I
K
L
I
D
F
G
I
A
--
H
K
I
E
A
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
E
--
T
-----
K
Q
-------
E
T
L
T
N
I
-
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
A
Q
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
585
Blastp_CBE
45.19
31%
-2
- C2 -
-
5G15
1
AURKA_HUMAN
A:
[10-269]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
----
T
L
C
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
45.19
36%
13
- C2 -
-
2W4J
1
DAPK1_HUMAN
A:
[11-275]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
45.16
36%
17
- C2 -
-
3F5U
1
DAPK1_HUMAN
A:
[11-294]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
D
----
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
45.15
35%
21
- C2 -
-
6QMO
7
DAPK1_HUMAN
A:
[7-296]
----
F
R
Q
E
-
N
V
D
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
D
----
T
Q
Q
A
L
-
S
---
R
K
A
E
A
V
N
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
45.08
39%
-3
- C2 -
-
3I7C
1
?
A:
[24-350]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
K
----
D
K
I
-
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
------
G
----
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
-
L
T
Y
V
P
S
-
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
---
K
E
Q
I
S
V
--SLDNAILN
I
R
Q
F
Q
G
T
Q
K
L
A
QAALLY-
G
S
K
L
T
S
Q
---
D
E
-
T
K
E
L
T
A
I
-----
F
H
-
K
D
K
N
G
D
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
317
Blastp_CBE
45.01
38%
-18
- C2 -
-
4CZT
3
CIPKN_ARATH
A:
[12-270]
-------------
K
Y
E
L
G
R
T
-
L
-
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
--
I
D
K
E
---
K
V
L
--
K
------
N
K
----
M
I
---------
A
---
Q
I
K
----
R
E
I
S
T
-
M
K
L
I
-
K
-
H
-
P
N
V
I
R
M
F
E
V
M
A
S
--
K
T
K
I
-----
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
--
G
----
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
N
------
G
-
A
-
L
K
V
S
D
F
G
L
S
--
A
L
P
Q
Q
V
R
E
D
G
L
LH
T
T
C
-
G
T
P
N
Y
V
A
P
E
V
I
-----
N
------
N
---
K
G
Y
D
G
A
K
-
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
------
E
---
D
-
S
--
N
-----
L
T
-------
S
L
Y
K
K
I
F
K
A
---
E
F
T
C
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
45.00
38%
-20
- C2 -
-
4CZU
3
CIPKN_ARATH
A:
[12-273]
-------------
K
Y
E
L
G
R
T
-
L
-
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
--
I
D
K
E
---
K
V
L
--
K
------
N
K
----
M
I
---------
A
---
Q
I
K
----
R
E
I
S
T
-
M
K
L
I
-
K
-
H
-
P
N
V
I
R
M
F
E
V
M
A
S
--
K
T
K
I
-----
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
--
G
----
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
N
------
G
-
A
-
L
K
V
S
D
F
G
L
S
--
A
L
P
Q
Q
V
R
E
D
G
L
LH
D
T
C
-
G
T
P
N
Y
V
A
P
E
V
I
-----
N
------
N
---
K
G
Y
D
G
A
K
-
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
------
E
---
D
-
S
--
N
-----
L
T
-------
S
L
Y
K
K
I
F
K
A
---
E
F
T
C
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
44.97
39%
-18
- C2 -
-
4A9S
1
CHK2_HUMAN
A:
[16-284]
------------
D
E
Y
I
M
S
K
T
-
L
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
----------------------------------PAL
N
V
E
----
T
E
I
E
I
-
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
D
Y
------
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
-
D
-
C
-
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
T
S
L
M
R
--
T
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
---
E
H
R
--
T
-----
Q
V
-------
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
44.83
39%
-28
- C2 -
-
4BDB
10
CHK2_HUMAN
A:
[16-284]
------------
D
E
Y
I
M
S
K
T
-
L
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
----------------------------------L--
N
V
E
----
T
E
I
E
I
-
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
D
Y
------
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
-
D
-
C
-
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
-
E
T
S
L
M
R
--
T
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
---
E
H
R
--
T
-----
Q
V
-------
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
269
Blastp_CBE
44.71
36%
13
- C2 -
-
1P4F
1
DAPK1_HUMAN
A:
[10-292]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
--------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V----
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
K
---------
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
44.68
38%
-19
- C2 -
-
4CZU
3
CIPKN_ARATH
B:
[12-274]
-------------
K
Y
E
L
G
R
T
-
L
-
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
--
I
D
K
E
---
K
V
L
--
K
------
N
K
----
M
I
---------
A
---
Q
I
K
----
R
E
I
S
T
-
M
K
L
I
-
K
-
H
-
P
N
V
I
R
M
F
E
V
M
A
S
--
K
T
K
I
-----
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
--
G
----
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
N
------
G
-
A
-
L
K
V
S
D
F
G
L
S
--
A
L
P
Q
Q
V
R
E
D
G
L
LH
D
T
C
-
G
T
P
N
Y
V
A
P
E
V
I
-----
N
------
N
---
K
G
Y
D
G
A
K
-
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
------
E
---
D
-
S
--
N
-----
L
T
-------
S
L
Y
K
K
I
F
K
A
---
E
F
T
C
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
588
Blastp_CBE
44.54
31%
-15
- C2 -
-
4C3P
1
AURKA_HUMAN
D:
[10-269]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
----------
L
C
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
44.50
35%
-23
- C2 -
-
1NY3
1
MAPK2_HUMAN
A:
[61-345]
------------
D
D
Y
K
V
T
S
Q
V
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
--
L
-------------------
Q
----
D
C
---------
P
---
K
A
R
----
R
E
V
E
L
H
W
R
A
S
-
Q
-
C
-
P
H
I
V
R
I
V
D
-
V
Y
E
--
N
L
Y
A
GRKCL
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
-----------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
-
P
-
N
-
A
-
I
-
L
K
L
T
D
F
G
F
A
--
K
E
T
T
S
-
H
------------
P
Y
Y
V
A
P
E
V
L
-----
G
------
P
---
E
K
Y
-
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
------
Y
---
S
-------------------
G
M
K
T
R
I
-
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
----
M
----
Q
S
T
----
K
V
P
Q
T
P
L
---
H
---
T
S
R
V
--------
L
K
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
44.46
39%
-19
- C2 -
-
2WTI
3
CHK2_HUMAN
A:
[16-284]
------------
D
E
Y
I
M
S
K
T
-
L
-
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
----------------------------------PAL
N
V
E
----
T
E
I
E
I
-
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
D
Y
------
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
-
D
-
C
-
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
-
E
T
S
L
M
R
--
T
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
---
E
H
R
--
T
-----
Q
V
-------
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
587
Blastp_CBE
44.39
31%
-11
- C2 -
-
4C3R
1
AURKA_HUMAN
A:
[10-267]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
---------------
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
44.23
31%
-10
- C2 -
-
5L8J
5
AURKA_HUMAN
A:
[13-273]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--------------------
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
44.19
39%
-5
- C2 -
-
3NYV
1
?
A:
[24-354]
----------
F
S
D
R
Y
K
G
Q
R
V
-
L
-
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
--
I
S
K
R
---
Q
-
V
--
K
------
Q
K
T---
D
K
---------
E
---
S
L
L
----
R
E
V
Q
L
-
L
K
Q
L
-
D
-
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
--
K
G
Y
F
-----
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
----
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
-
D
-
A
-
N
-
I
R
I
I
D
F
G
L
S
--
T
H
F
E
A
S
K
K
K
----
D
K
I
-
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
------
G
----
T
Y
-
D
E
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
---
G
-
A
--
N
-----
E
Y
-------
D
I
L
K
K
V
-
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
-
L
T
Y
V
P
S
-
R
I
S
A
R
D
A
L
D
H
E
W
I
------------------
Q
T
Y
-
T
---
K
E
Q
I
----SLDNAILN
I
R
Q
F
Q
G
T
Q
K
L
A
QAALLY-
G
S
K
L
T
S
Q
---
D
E
-
T
K
E
L
T
A
I
-----
F
H
-
K
D
K
N
G
D
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
44.13
36%
20
- C2 -
-
6AAR
1
DAPK1_HUMAN
A:
[11-277]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
--------------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
F
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
----
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
275
Blastp_CBE
43.94
39%
-7
- C2 -
-
4BDK
4
CHK2_HUMAN
A:
[16-284]
------------
D
E
Y
I
M
S
K
T
-
L
-
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
----------------------------------AL-
N
V
E
----
T
E
I
E
I
-
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
D
Y
------
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
-
D
-
C
-
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
G
E
T
S
L
M
R
--
T
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
---
E
H
R
--
T
-----
Q
V
-------
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
493
Blastp_CBE
43.83
37%
-30
- C2 -
-
4QFG
1
A:
[18-399]
--------------
Y
I
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
---
K
-
I
--
R
------
S
L
----
D
V
V--------
G
---
K
I
R
----
R
E
I
Q
N
-
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
S
D
I
-----
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
-
N
-
A
------
K
I
A
D
F
G
L
S
---
N
M
M
S
D
G
E
-
F
L
--
R
S
C
-
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
---
D
-
D
--
H
-----
V
P
-------
T
L
F
K
K
I
-
C
D
G
I
--
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
----
K
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
43.80
36%
1
- C2 -
-
3ZXT
1
DAPK1_HUMAN
B:
[11-276]
------------
D
Y
Y
D
T
G
E
E
-
L
-
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K--------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
--------------
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
-
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
---
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
489
Blastp_CBE
43.67
37%
-32
- C2 -
-
5T5T
2
AAPK1_RAT
A:
[18-396]
--------------
Y
I
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
---
K
-
I
--
R
------
S
L
----
D
V
V--------
G
---
K
I
R
----
R
E
I
Q
N
-
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
S
D
I
-----
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
-
N
-
A
------
K
I
A
D
F
G
L
S
---
N
M
M
S
D
G
E
-
F
L
--
R
S
C
-
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
---
D
-
D
--
H
-----
V
P
-------
T
L
F
K
K
I
-
C
D
G
I
--
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
----
K
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
281
Blastp_CBE
43.66
39%
-10
- C2 -
-
4BDE
5
CHK2_HUMAN
A:
[16-284]
------------
D
E
Y
I
M
S
K
T
-
L
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
----------------------------------AL-
N
V
E
----
T
E
I
E
I
-
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
D
Y
------
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
-
D
-
C
-
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
T
S
L
M
R
--
T
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
---
E
H
R
--
T
-----
Q
V
-------
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
43.62
32%
-2
- C2 -
-
2WTW
1
AURKA_HUMAN
A:
[13-271]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
----------
C
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
43.56
36%
-8
- C2 -
-
2JBO
1
MAPK2_HUMAN
A:
[23-293]
------------
D
D
Y
K
V
T
S
Q
V
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
--
L
-------------------
Q
----
D
C
---------
P
---
K
A
R
----
R
E
V
E
L
H
W
R
A
S
-
Q
-
C
-
P
H
I
V
R
I
V
D
-
V
Y
E
--
N
L
Y
A
GRKCL
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
----
A
-
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
-
P
-
N
-
A
-
I
-
L
K
L
T
D
F
G
F
A
--
K
E
T
T
-----------
C
-
Y
T
P
Y
Y
V
A
P
E
V
L
-----
G
------
P
---
E
K
Y
-
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
------
Y
---
S
-
N
--
H
GLAI-
S
P
-------
G
M
K
T
R
I
-
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
----
M
----
Q
S
T
----
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
43.56
39%
-17
- C2 -
-
2WTD
4
CHK2_HUMAN
A:
[16-284]
------------
D
E
Y
I
M
S
K
T
-
L
-
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
----------------------------------PAL
N
V
E
----
T
E
I
E
I
-
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
D
Y
------
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
-
D
-
C
-
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
T
S
L
M
R
--
T
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
---
E
H
R
--
T
-----
Q
V
-------
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
43.42
37%
-30
- C2 -
-
4QFR
2
?
A:
[18-403]
--------------
Y
I
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
---
K
-
I
--
R
------
S
L
----
D
V
V--------
G
---
K
I
R
----
R
E
I
Q
N
-
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
S
D
I
-----
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
-
N
-
A
------
K
I
A
D
F
G
L
S
---
N
M
M
S
D
G
E
-
F
L
--
R
S
C
-
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
---
D
-
D
--
H
-----
V
P
-------
T
L
F
K
K
I
-
C
D
G
I
--
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
----
K
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
488
Blastp_CBE
43.31
37%
-28
- C2 -
-
5UFU
2
AAPK1_MOUSE (first)
A:
[18-396]
--------------
Y
I
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
---
K
-
I
--
R
------
S
L
----
D
V
V--------
G
---
K
I
R
----
R
E
I
Q
N
-
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
S
D
I
-----
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
-
N
-
A
------
K
I
A
D
F
G
L
S
---
N
M
M
S
D
G
E
-
F
L
--
R
S
C
-
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
---
D
-
D
--
H
-----
V
P
-------
T
L
F
K
K
I
-
C
D
G
I
--
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
----
K
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
43.30
39%
-17
- C2 -
-
2WTJ
5
CHK2_HUMAN
A:
[16-284]
------------
D
E
Y
I
M
S
K
T
-
L
-
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
----------------------------------PAL
N
V
E
----
T
E
I
E
I
-
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
D
Y
------
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
-
D
-
C
-
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
-
E
T
S
L
M
R
--
T
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
---
E
H
R
--
T
-----
Q
V
-------
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
43.20
36%
12
- C2 -
-
3ZXT
1
DAPK1_HUMAN
C:
[11-276]
------------
D
Y
Y
D
T
G
E
E
-
L
---
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
--
I
K
K
R
---
R
-
T
K-
S
------
S
R
RGV-
S
R
---------
E
---
D
I
E
----
R
E
V
S
I
-
L
K
E
I
-
Q
-
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
-----
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
-
K
-
P
-
R
-
I
K
I
I
D
F
G
L
A
--
H
K
I
D
---------------
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
D
--
T
-----
K
Q
-------
E
T
L
A
N
V
-
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
----
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
42.98
37%
-28
- C2 -
-
6E4W
2
?
A:
[18-403]
--------------
Y
I
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
---
K
-
I
--
R
------
S
L
----
D
V
V--------
G
---
K
I
R
----
R
E
I
Q
N
-
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
S
D
I
-----
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
-
N
-
A
------
K
I
A
D
F
G
L
S
---
N
M
M
S
D
G
E
-
F
L
--
R
S
C
-
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
---
D
-
D
--
H
-----
V
P
-------
T
L
F
K
K
I
-
C
D
G
I
--
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
----
K
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
42.94
36%
-27
- C2 -
-
2PZY
1
MAPK2_HUMAN
B:
[21-291]
------------
D
D
Y
K
V
T
S
Q
V
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
--
L
-------------------
Q
----
D
C
---------
P
---
K
A
R
----
R
E
V
E
L
H
W
R
A
S
-
Q
-
C
-
P
H
I
V
R
I
V
D
-
V
Y
E
--
N
L
Y
A
GRKCL
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
----
A
-
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
-
P
-
N
-
A
-
I
-
L
K
L
T
D
F
G
F
A
--
K
E
T
---------------
T
P
Y
Y
V
A
P
E
V
L
-----
G
------
P
---
E
K
Y
-
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
------
Y
---
S
-------------------
G
M
K
T
R
I
-
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
----
M
----
Q
S
T
----
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
42.90
34%
-30
- C2 -
-
4JXF
2
PLK4_HUMAN
A:
[7-264]
------------
E
D
F
K
V
G
N
L
-
L
-
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
--
I
D
K
K
---
A
-
M
Y-
K
------
A
G
----
M
V
---------
Q
---
R
V
Q
----
N
E
V
K
I
-
H
C
Q
L
-
K
-
H
-
P
S
I
L
E
L
Y
N
Y
F
E
D
--
S
N
Y
V
-----
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V-
K
----
P
-
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
---
T
-
R
-
N
-
M
-
N
-
I
K
I
A
D
F
G
L
A
--
T
Q
L
K
M
P
H
-------------------------------------------
E
-
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
---------------------
V
K
-------
N
T
L
N
K
V
-
V
L
A
D
Y
E
M
P
S
----
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
----
S
----
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
42.84
36%
-14
- C2 -
-
2PZY
1
MAPK2_HUMAN
A:
[21-291]
------------
D
D
Y
K
V
T
S
Q
V
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
--
L
-------------------
Q
----
D
C
---------
P
---
K
A
R
----
R
E
V
E
L
H
W
R
A
S
-
Q
-
C
-
P
H
I
V
R
I
V
D
-
V
Y
E
--
N
L
Y
A
GRKCL
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
-------
A
-
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
-
P
-
N
-
A
-
I
-
L
K
L
T
D
F
G
F
A
--
K
E
T
---------------
T
P
Y
Y
V
A
P
E
V
L
-----
G
------
P
---
E
K
Y
-
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
------
Y
---
S
-
N
--
H
GLAI-
S
P
-------
G
M
K
T
R
I
-
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
----
M
----
Q
S
T
----
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
42.81
39%
-14
- C2 -
-
4A9U
10
CHK2_HUMAN
A:
[16-284]
------------
D
E
Y
I
M
S
K
T
-
L
-
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
---------------------------------
D
PAL
N
V
E
----
T
E
I
E
I
-
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
D
Y
------
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
-
D
-
C
-
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
T
S
L
M
R
--
T
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
---
E
H
R
--
T
-----
Q
V
-------
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
42.78
39%
-4
- C2 -
-
2XBJ
1
CHK2_HUMAN
A:
[16-284]
------------
D
E
Y
I
M
S
K
T
-
L
-
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
----------------------------------AL-
N
V
E
----
T
E
I
E
I
-
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
D
Y
------
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
-
D
-
C
-
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
T
S
L
M
R
--
T
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
---
E
H
R
--
T
-----
Q
V
-------
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
42.74
37%
-31
- C2 -
-
6E4U
2
AAPK1_RAT
A:
[18-399]
--------------
Y
I
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
---
K
-
I
--
R
------
S
L
----
D
V
V--------
G
---
K
I
R
----
R
E
I
Q
N
-
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
S
D
I
-----
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
-
N
-
A
------
K
I
A
D
F
G
L
S
---
N
M
M
S
D
G
E
-
F
L
--
R
S
C
-
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
---
D
-
D
--
H
-----
V
P
-------
T
L
F
K
K
I
-
C
D
G
I
--
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
----
K
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
42.63
39%
-19
- C2 -
-
2WTC
1
CHK2_HUMAN
A:
[16-284]
------------
D
E
Y
I
M
S
K
T
-
L
-
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
--
I
S
K
----------------------------------PAL
N
V
E
----
T
E
I
E
I
-
L
K
K
L
-
N
-
H
-
P
C
I
I
K
I
K
N
F
F
D
A
--
E
D
Y
------
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
----
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
-
E
-
D
-
C
-
L
-
I
K
I
T
D
F
G
H
S
---
K
I
L
--
T
S
L
M
R
--
T
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
-----
V
------
S
VGT
A
G
Y
-
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
---
E
H
R
--
T
-----
Q
V
-------
S
L
K
D
Q
I
-
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
487
Blastp_CBE
42.62
37%
-29
- C2 -
-
6E4T
2
?
A:
[18-403]
--------------
Y
I
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
---
K
-
I
--
R
------
S
L
----
D
V
V--------
G
---
K
I
R
----
R
E
I
Q
N
-
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
S
D
I
-----
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
-
N
-
A
------
K
I
A
D
F
G
L
S
---
N
M
M
S
D
G
E
-
F
L
--
R
S
C
-
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
---
D
-
D
--
H
-----
V
P
-------
T
L
F
K
K
I
-
C
D
G
I
--
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
----
K
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
374
Blastp_CBE
42.53
36%
-12
- C2 -
-
3R30
1
MAPK2_HUMAN
A:
[16-286]
------------
D
D
Y
K
V
T
S
Q
V
L
-
G
L
G
I
-
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
--
L
-------------------
Q
----
D
C
---------
P
---
K
A
R
----
R
E
V
E
L
H
W
R
A
S
-
Q
-
C
-
P
H
I
V
R
I
V
D
-
V
Y
E
--
N
L
Y
A
GRKCL
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
-----------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
-
P
-
N
-
A
-
I
-
L
K
L
T
D
F
G
F
A
--
K
E
T
T
------------------------------------
P
---
E
K
Y
-
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
------
Y
---
S
-------------------
G
M
K
T
R
I
-
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
----
M
----
Q
S
T
----
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
42.40
37%
-44
- C2 -
-
6B2E
2
AAPK2_HUMAN
A:
[29-383]
--------------
Y
V
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
---
K
-
I
--
R
------
S
L
----
D
V
V--------
G
---
K
I
K
----
R
E
I
Q
N
-
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
T
D
F
-----
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
--
G
----
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
-
N
-
A
------
K
I
A
D
F
G
L
S
---
N
M
M
S
D
G
E
-
F
L
--
R
S
C
-
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
---
D
-
E
--
H
-----
V
P
-------
T
L
F
K
K
I
-
R
G
G
V
F
Y
I
P
----
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
----
K
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
558
Blastp_CBE
42.38
34%
0
- C2 -
-
6CMJ
6
KKCC2_HUMAN
B:
[32-307]
---------
Q
L
-
D
Q
Y
T
L
K
D
E
-
I
-
G
K
G
S
Y
G
V
V
K
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
--
L
S
K
K
---
K
-
L
--
I
------
R
Q
----
A
G
GCIQPRGPI
E
---
Q
V
Y
----
Q
E
I
A
I
-
L
K
K
L
-
D
-
H
-
P
N
V
V
K
L
V
E
V
L
D
D
PN
E
D
H
L
-----
Y
M
V
F
E
L
V
N
Q
G
P
V
M
E
-
V
P
T
L
--
K
----
P
-
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
G
----
E
-
D
-
G
-
H
-
I
K
I
A
D
F
G
V
S
--
N
E
F
K
G
-
S
D
A
L
L
--
N
T
V
-
G
T
P
A
F
M
A
P
E
S
L
SET--
R
------
K
---
I
F
S
-
G
K
A
-
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
------
M
---
D
-
E
--
R
-----
I
M
-------
C
L
H
K
S
I
-
K
S
Q
A
L
E
F
P
--
D
Q
P
D
I
A
E
D
L
K
D
L
I
T
R
M
L
D
K
N
P
E
S
R
I
V
V
P
E
I
K
L
H
P
W
V
----
T
----
R
H
G
----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
354
Blastp_CBE
42.21
34%
-18
- C2 -
-
3COK
1
PLK4_HUMAN
A:
[1-267]
--
S
L
A
T
C
I
G
E
K
I
E
D
F
K
V
G
N
L
-
L
-
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
--
I
D
K
K
---
A
-
M
Y-
K
------
A
G
----
M
V
---------
Q
---
R
V
Q
----
N
E
V
K
I
-
H
C
Q
L
-
K
-
H
-
P
S
I
L
E
L
Y
N
Y
F
E
D
--
S
N
Y
V
-----
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V-
K
----
P
-
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
---
T
-
R
-
N
-
M
-
N
-
I
K
I
A
D
F
G
L
A
--
T
Q
L
K
----------------------------------------------
E
-
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
------
D
---
T
-
D
--
T
-----
V
------------
K
V
-
V
L
A
D
Y
E
M
P
S
----
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
----
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
496
Blastp_CBE
41.94
37%
-32
- C2 -
-
4CFH
1
AAPK1_RAT
A:
[35-348]
--------------
Y
I
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
---
K
-
I
--
R
------
S
L
----
D
V
V--------
G
---
K
I
R
----
R
E
I
Q
N
-
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
S
D
I
-----
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
-
N
-
A
------
K
I
A
D
F
G
L
S
---
N
M
M
S
D
G
E
-
F
L
--
R
S
C
-
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
---
D
-
D
--
H
-----
V
P
-------
T
L
F
K
K
I
-
C
D
G
I
--
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
----
K
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
490
Blastp_CBE
41.88
37%
-30
- C2 -
-
5KQ5
2
?
A:
[18-401]
--------------
Y
I
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
---
K
-
I
--
R
------
S
L
----
D
V
V--------
G
---
K
I
R
----
R
E
I
Q
N
-
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
S
D
I
-----
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
-
N
-
A
------
K
I
A
D
F
G
L
S
---
N
M
M
S
D
G
E
-
F
L
--
R
S
C
-
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
---
D
-
D
--
H
-----
V
P
-------
T
L
F
K
K
I
-
C
D
G
I
--
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
----
K
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
41.86
33%
-33
- C2 -
-
5WVD
1
MKNK1_HUMAN
A:
[12-302]
---------
K
F
E
D
M
Y
K
L
T
S
E
-
L
L
G
E
G
A
Y
A
K
V
Q
G
A
V
S
L
Q
N
G
K
E
Y
A
V
K
I
--
I
E
K
Q
---
A
-
G
--
H
------
S
R
----
S
R
---------
V
---
F
R
E
----
V
E
T
-
L
-
Y
Q
C
Q
-
G
-
N
-
K
N
I
L
E
L
I
E
F
F
E
D
--
D
T
R
F
-----
Y
L
V
F
E
K
L
Q
G
G
S
I
L
A
H
I
Q
K
Q
--
K
----
H
-
F
N
E
R
E
A
S
R
V
V
R
D
V
A
A
A
L
D
F
L
H
T
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
S
P
E
-
K
-
V
-
S
-
P
-
V
K
I
C
D
F
D
L
G
--
S
G
-------------------
Y
M
A
P
E
V
V
EVFTD
Q
------
A
---
T
F
Y
-
D
K
R
-
C
D
L
W
S
L
G
V
V
L
Y
I
M
L
S
G
Y
P
P
F
----------------------------------------
K
Y
E
F
P
D
K
D
W
A
H
I
S
S
E
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
491
Blastp_CBE
41.73
37%
-31
- C2 -
-
4QFS
2
A:
[18-403]
--------------
Y
I
L
G
D
T
-
L
-
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
--
L
N
R
Q
---
K
-
I
--
R
------
S
L
----
D
V
V--------
G
---
K
I
R
----
R
E
I
Q
N
-
L
K
L
F
-
R
-
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
--
P
S
D
I
-----
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
----
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
-
N
-
A
------
K
I
A
D
F
G
L
S
---
N
M
M
S
D
G
E
-
F
L
--
R
S
C
-
G
S
P
N
Y
A
A
P
E
V
I
-----
S
------
G
---
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
---
D
-
D
--
H
-----
V
P
-------
T
L
F
K
K
I
-
C
D
G
I
--
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
K
D
I
R
E
H
E
W
F
----
K
----
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
408
Blastp_CBE
41.68
36%
2
- C2 -
-
2PZY
1
MAPK2_HUMAN
C:
[21-291]
------------
D
D
Y
K
V
T
S
Q
V
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
--
L
-------------------
Q
----
D
C
---------
P
---
K
A
R
----
R
E
V
E
L
H
W
R
A
S
-
Q
-
C
-
P
H
I
V
R
I
V
D
-
V
Y
E
--
N
L
Y
A
GRKCL
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
----
A
-
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
-
P
-
N
-
A
-
I
-
L
K
L
T
D
F
G
F
A
--
K
E
T
---------------
T
P
Y
Y
V
A
P
E
V
L
-----
G
------
P
---
E
K
Y
-
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
------
Y
---
S
-
N
--
H
GLAI-
S
P
-------
G
M
K
T
R
I
-
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
----
M
----
Q
S
T
----
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
559
Blastp_CBE
41.66
34%
3
- C2 -
-
6CMJ
5
KKCC2_HUMAN
A:
[32-307]
---------
Q
L
-
D
Q
Y
T
L
K
D
E
-
I
-
G
K
G
S
Y
G
V
V
K
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
--
L
S
K
K
---
K
-
L
--
I
------
R
Q
----
A
G
GCIQPRGPI
E
---
Q
V
Y
----
Q
E
I
A
I
-
L
K
K
L
-
D
-
H
-
P
N
V
V
K
L
V
E
V
L
D
D
PN
E
D
H
L
-----
Y
M
V
F
E
L
V
N
Q
G
P
V
M
E
-
V
P
T
L
--
K
----
P
-
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
G
----
E
-
D
-
G
-
H
-
I
K
I
A
D
F
G
V
S
--
N
E
F
K
G
-
S
D
A
L
L
--
N
T
V
-
G
T
P
A
F
M
A
P
E
S
L
SET--
R
------
K
---
I
F
S
-
G
K
A
-
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
------
M
---
D
-
E
--
R
-----
I
M
-------
C
L
H
K
S
I
-
K
S
Q
A
L
E
F
P
--
D
Q
P
D
I
A
E
D
L
K
D
L
I
T
R
M
L
D
K
N
P
E
S
R
I
V
V
P
E
I
K
L
H
P
W
V
----
T
----
R
H
G
----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
534
Blastp_CBE
41.43
31%
-8
- C2 -
-
4CEG
3
AURKA_HUMAN
A:
[13-273]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
575
Blastp_CBE
41.41
32%
-6
- C2 -
-
5ORS
2
AURKA_HUMAN
A:
[5-265]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
573
Blastp_CBE
41.33
32%
-5
- C2 -
-
5ORV
2
AURKA_HUMAN
A:
[5-265]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
562
Blastp_CBE
41.32
32%
-8
- C2 -
-
5OSF
2
AURKA_HUMAN
A:
[5-265]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
564
Blastp_CBE
41.27
32%
-6
- C2 -
-
5OS6
2
AURKA_HUMAN
A:
[5-265]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
554
Blastp_CBE
41.23
32%
-5
- C2 -
-
5OSD
2
AURKA_HUMAN
A:
[7-267]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
41.21
36%
-28
- C2 -
-
3R2Y
1
MAPK2_HUMAN
A:
[16-286]
------------
D
D
Y
K
V
T
S
Q
V
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
--
L
-------------------
Q
----
D
C
---------
P
---
K
A
R
----
R
E
V
E
L
H
W
R
A
S
-
Q
-
C
-
P
H
I
V
R
I
V
D
-
V
Y
E
--
N
L
Y
A
GRKCL
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
-----------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
-
P
-
N
-
A
-
I
-
L
K
L
T
D
F
G
F
A
--
K
E
T
T
--------------------------------------------
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
------
Y
------------------------
M
K
T
R
I
-
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
----
M
----
Q
S
T
----
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
569
Blastp_CBE
41.19
32%
-8
- C2 -
-
5ORZ
2
AURKA_HUMAN
A:
[5-265]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
580
Blastp_CBE
41.18
32%
-9
- C2 -
-
5ORL
2
AURKA_HUMAN
A:
[5-265]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
578
Blastp_CBE
41.13
32%
-6
- C2 -
-
5ORO
2
AURKA_HUMAN
A:
[5-265]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
526
Blastp_CBE
41.12
31%
-6
- C2 -
-
6R4C
2
AURKA_HUMAN
A:
[13-273]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
563
Blastp_CBE
41.10
32%
-7
- C2 -
-
5OSE
2
AURKA_HUMAN
A:
[5-265]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
41.02
31%
-7
- C2 -
-
6R4B
1
AURKA_HUMAN
A:
[13-273]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
579
Blastp_CBE
41.01
32%
-7
- C2 -
-
5ORN
2
AURKA_HUMAN
A:
[5-265]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
577
Blastp_CBE
40.93
32%
-8
- C2 -
-
5ORP
2
AURKA_HUMAN
A:
[5-265]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
572
Blastp_CBE
40.91
32%
-5
- C2 -
-
5ORW
2
AURKA_HUMAN
A:
[5-265]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
568
Blastp_CBE
40.91
32%
-8
- C2 -
-
5OS0
2
AURKA_HUMAN
A:
[5-265]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
353
Blastp_CBE
40.82
34%
-16
- C2 -
-
3COK
1
PLK4_HUMAN
B:
[1-267]
--
S
L
A
T
C
I
G
E
K
I
E
D
F
K
V
G
N
L
-
L
-
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
--
I
D
K
K
---
A
-
M
Y-
K
------
A
G
----
M
V
---------
Q
---
R
V
Q
----
N
E
V
K
I
-
H
C
Q
L
-
K
-
H
-
P
S
I
L
E
L
Y
N
Y
F
E
D
--
S
N
Y
V
-----
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V-
K
----
P
-
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
---
T
-
R
-
N
-
M
-
N
-
I
K
I
A
D
F
G
L
A
--
T
Q
L
K
---------------------------------------------
L
E
-
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
------------------------------
N
T
L
N
K
V
-
V
L
A
D
Y
E
M
P
S
----
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
----
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
567
Blastp_CBE
40.77
32%
-5
- C2 -
-
5OS1
2
AURKA_HUMAN
A:
[5-265]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
570
Blastp_CBE
40.76
32%
-8
- C2 -
-
5ORY
2
AURKA_HUMAN
A:
[5-265]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
571
Blastp_CBE
40.74
32%
-8
- C2 -
-
5ORX
2
AURKA_HUMAN
A:
[5-265]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
520
Blastp_CBE
40.71
32%
-6
- C2 -
-
5LXM
6
AURKA_HUMAN
A:
[11-272]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
N
-
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
565
Blastp_CBE
40.59
32%
-6
- C2 -
-
5OS4
2
AURKA_HUMAN
A:
[5-265]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
566
Blastp_CBE
40.50
32%
-7
- C2 -
-
5OS3
2
AURKA_HUMAN
A:
[5-265]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
533
Blastp_CBE
40.43
31%
-5
- C2 -
-
5G1X
1
AURKA_HUMAN
A:
[13-271]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
576
Blastp_CBE
40.29
32%
-5
- C2 -
-
5ORR
2
AURKA_HUMAN
A:
[5-265]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
574
Blastp_CBE
39.97
32%
-7
- C2 -
-
5ORT
2
AURKA_HUMAN
A:
[5-265]
------------
E
D
F
E
I
G
R
P
-
L
-
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
--
L
F
K
A
---
Q
-
L
EK
A
------
G
V
----
E
H
---------
Q
----
L
R
----
R
E
V
E
I
-
Q
S
H
L
-
R
-
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
-----
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--
S
----
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-----
A
-
G
-
E
-
L
K
I
A
D
F
G
W
S
--
V
H
A
P
S
S
R
R
T
-----
L
A
-
G
T
L
D
Y
L
P
P
E
M
I
-----
E
------
G
---
R
M
H
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
------
E
---
A
-
N
--
T
-----
Y
Q
-------
E
T
Y
K
R
I
-
S
R
V
E
F
T
F
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
----
T
----
A
N
S
----
S
K
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
38.81
36%
-2
- C2 -
-
3FYK
1
MAPK2_HUMAN
X:
[17-287]
------------
D
D
Y
K
V
T
S
Q
V
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
--
L
-------------------
Q
----
D
C
---------
P
---
K
A
R
----
R
E
V
E
L
H
W
R
A
S
-
Q
-
C
-
P
H
I
V
R
I
V
D
-
V
Y
E
--
N
L
Y
A
GRKCL
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
----
A
-
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
-
P
-
N
-
A
-
I
-
L
K
L
T
D
F
G
F
A
--
K
E
T
T
S
----------------------------------------
K
Y
-
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
------
Y
---
S
----------------------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
----
M
----
Q
S
T
----
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
38.26
36%
-2
- C2 -
-
2P3G
1
MAPK2_HUMAN
X:
[17-287]
------------
D
D
Y
K
V
T
S
Q
V
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
--
L
-------------------
Q
----
D
C
---------
P
---
K
A
R
----
R
E
V
E
L
H
W
R
A
S
-
Q
-
C
-
P
H
I
V
R
I
V
D
-
V
Y
E
--
N
L
Y
A
GRKCL
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
----
A
-
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
-
P
-
N
-
A
-
I
-
L
K
L
T
D
F
G
F
A
--
K
E
T
T
S
----------------------------------------
K
Y
-
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
------
Y
---
S
----------------------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
----
M
----
Q
S
T
----
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
37.26
36%
3
- C2 -
-
3FYJ
1
MAPK2_HUMAN
X:
[17-287]
------------
D
D
Y
K
V
T
S
Q
V
L
-
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
--
L
-------------------
Q
----
D
C
---------
P
---
K
A
R
----
R
E
V
E
L
H
W
R
A
S
-
Q
-
C
-
P
H
I
V
R
I
V
D
-
V
Y
E
--
N
L
Y
A
GRKCL
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
GD
Q
----
A
-
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
-
P
-
N
-
A
-
I
-
L
K
L
T
D
F
G
F
A
--
K
E
T
T
S
----------------------------------------
K
Y
-
D
K
S
-
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
------
Y
---
S
----------------------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
----
M
----
Q
S
T
----
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
36.59
33%
-47
- C2 -
-
5WVD
1
MKNK1_HUMAN
B:
[12-302]
---------
K
F
E
D
M
Y
K
L
T
S
E
-
L
L
G
E
G
A
Y
A
K
V
Q
G
A
V
S
L
Q
N
G
K
E
Y
A
V
K
I
--
I
E
K
Q
---
A
-
G
--
H
------
S
R
----
S
R
---------
V
---
F
R
E
----
V
E
T
-
L
-
Y
Q
C
Q
-
G
-
N
-
K
N
I
L
E
L
I
E
F
F
E
D
--
D
T
R
F
-----
Y
L
V
F
E
K
L
Q
G
G
S
I
L
A
H
I
Q
----------------
A
S
R
V
V
R
D
V
A
A
A
L
D
F
L
H
T
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
S
P
----
V
-
S
-
P
-
V
K
I
C
D
F
D
L
G
--
S
G
M
-----------------
E
Y
M
A
P
E
V
V
EVFTD
Q
------
A
---
T
F
Y
-
D
K
R
-
C
D
L
W
S
L
G
V
V
L
Y
I
M
L
S
G
Y
P
-----------------------------------------------------------
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
189
Blastp_CBE
35.80
39%
4
- C2 -
-
2J90
2
DAPK3_HUMAN
A:
[26-290]
------------
D
H
Y
E
M
G
E
E
-
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
--
I
K
K
R
---
R
-
L
--
S
------
S
R
RGV-
S
R
---------
E
---
E
I
E
----
R
E
V
N
I
-
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
--
K
T
D
V
-----
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
--
E
----
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
-
N
-
P
-
R
-
I
K
L
I
D
F
G
I
A
--
H
K
I
E
A
-------------
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
E
--
T
-----
K
Q
-------
E
T
L
T
N
I
-
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
I
A
-
Q
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
34.54
39%
9
- C2 -
-
2J90
3
DAPK3_HUMAN
B:
[27-290]
-------------
H
Y
E
M
G
E
E
-
L
-
G
S
G
Q
F
A
I
V
R
K
C
R
Q
----
K
E
Y
A
A
K
F
--
I
K
K
R
---
R
-
L
--
S
------
S
R
RGV-
S
R
---------
E
---
E
I
E
----
R
E
V
N
I
-
L
R
E
I
-
R
-
H
-
P
N
I
I
T
L
H
D
I
F
E
N
--
K
T
D
V
-----
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
--
E
------
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
-
N
-
P
-
R
-
I
K
L
I
D
F
G
I
A
--
H
K
I
E
A
G
N
E
-
F
K
--
N
I
F
-
G
T
P
E
F
V
A
P
E
I
V
-----
N
------
Y
---
E
P
L
-
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
---
G
-
E
--
T
-----
K
Q
-------
E
T
L
T
N
I
-
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
I
A
-
Q
S
L
E
H
S
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------